CN114173774A - 用于治疗神经退行性和代谢性疾患的化合物 - Google Patents

用于治疗神经退行性和代谢性疾患的化合物 Download PDF

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CN114173774A
CN114173774A CN202080051371.6A CN202080051371A CN114173774A CN 114173774 A CN114173774 A CN 114173774A CN 202080051371 A CN202080051371 A CN 202080051371A CN 114173774 A CN114173774 A CN 114173774A
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alkyl
formula
compound
pharmaceutically acceptable
hydrogen
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C·拉斯梅扎斯
M·周
T·D·班尼斯特
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University of Florida Research Foundation Inc
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Scripps Research Institute
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080051371.6A 2019-05-14 2020-05-14 用于治疗神经退行性和代谢性疾患的化合物 Pending CN114173774A (zh)

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US201962847600P 2019-05-14 2019-05-14
US62/847,600 2019-05-14
PCT/US2020/032903 WO2020232255A1 (en) 2019-05-14 2020-05-14 Compounds for the treatment of neurodegenerative and metabolic disorders

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US (1) US12590094B2 (enExample)
EP (1) EP3968981A1 (enExample)
JP (2) JP7812051B2 (enExample)
CN (1) CN114173774A (enExample)
AU (2) AU2020274186A1 (enExample)
BR (1) BR112021022734A2 (enExample)
CA (2) CA3297266A1 (enExample)
IL (2) IL288001B2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116036279A (zh) * 2022-07-27 2023-05-02 上海交通大学医学院附属新华医院 Echs1抑制剂的用途

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021377893A1 (en) * 2020-11-12 2023-06-22 Scripps Research Institute, The Nicotinamide dinucleotide (nad) detection and quantification
JP2024501625A (ja) * 2020-12-11 2024-01-15 ザ スクリプス リサーチ インスティテュート 神経変性、変性及び代謝性障害の処置のための化合物並びにその使用
IL303924A (en) * 2020-12-18 2023-08-01 Scripps Research Inst Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders
CN117355300A (zh) * 2021-01-15 2024-01-05 佛罗里达大学研究基金会公司 化合物及其用于治疗神经退行性、退行性以及代谢疾病的用途
WO2022165173A1 (en) * 2021-01-28 2022-08-04 The Scripps Research Institute Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders
JP2024516827A (ja) 2021-04-30 2024-04-17 マインド メディシン， インコーポレイテッド Ｌｓｄ塩結晶形態
WO2022235531A1 (en) 2021-05-04 2022-11-10 Mind Medicine, Inc. Movement disorders
KR20240007258A (ko) * 2021-05-13 2024-01-16 유니버시티 오브 싸우스 캐롤라이나 리실 옥시다제의 억제제로서 비티아졸 유도체
AU2022331315B2 (en) 2021-08-19 2025-10-16 Definium Therapeutics US, Inc. Lyophilized orally disintegrating tablet formulations of d-lysergic acid diethylamide for therapeutic applications
CN121002020A (zh) * 2022-12-13 2025-11-21 韦夫布雷克治疗有限责任公司 治疗与蛋白质错误折叠相关的病症的化合物、组合物和方法
WO2025017207A1 (en) * 2023-07-20 2025-01-23 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Inhibitors of smndc1 and their therapeutic use
EP4643856A1 (en) * 2024-05-03 2025-11-05 Centre National de la Recherche Scientifique Carbazole derivatives used as neuroprotectants and in the treatment of disorders with reduced nad metabolism

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1251097A (zh) * 1997-02-13 2000-04-19 诺瓦提斯公司 具有血管生成抑制活性的酞嗪类化合物
WO2006003147A1 (en) * 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases
WO2017160864A1 (en) * 2016-03-14 2017-09-21 Board Of Regents, The University Of Texas System Hydralazine and active derivatives thereof for neuronal cell survival and regeneration

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2416525A1 (en) * 2000-08-09 2002-02-14 Astrazeneca Ab Indole, azaindole and indazole derivatives having vegf inhibiting activity
US6903101B1 (en) * 2000-08-10 2005-06-07 Bayer Pharmaceuticals Corporation Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
US7268137B2 (en) * 2002-11-07 2007-09-11 Campochiaro Peter A Ocular therapy
EP1865775A1 (en) * 2005-04-06 2007-12-19 Irm, Llc Diarylamine-containing compounds and compositions, and their use as modulators of steroid hormone nuclear receptors
WO2016085990A1 (en) * 2014-11-24 2016-06-02 The Regents Of The University Of Michigan Compositions and methods relating to inhibiting serine hyrdoxymethyltransferase 2 activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1251097A (zh) * 1997-02-13 2000-04-19 诺瓦提斯公司 具有血管生成抑制活性的酞嗪类化合物
WO2006003147A1 (en) * 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases
WO2017160864A1 (en) * 2016-03-14 2017-09-21 Board Of Regents, The University Of Texas System Hydralazine and active derivatives thereof for neuronal cell survival and regeneration

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LUNDIN A等: "Two novel fusion inhibitors of human respiratory syncytial virus", ANTIVIRAL RESEARCH, vol. 88, no. 3, 1 December 2010 (2010-12-01), pages 317 - 324, XP027509945, DOI: 10.1016/j.antiviral.2010.10.004 *
STN数据库REGISTRY检索: "CA号212142-33-1、212142-63-7", pages 1 - 2, Retrieved from the Internet <URL:www.stn.org> *

Cited By (1)

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