CN114166981B

CN114166981B - Dynamic correction method for chromatograph aging, storage medium and electronic device

Info

Publication number: CN114166981B
Application number: CN202210123125.8A
Authority: CN
Inventors: 王东强; 张慧
Original assignee: China Spectrum Tech Beijing Technology Co ltd
Current assignee: China Spectrum Tech Beijing Technology Co ltd
Priority date: 2022-02-10
Filing date: 2022-02-10
Publication date: 2022-04-26
Anticipated expiration: 2042-02-10
Also published as: CN114166981A

Abstract

The application relates to a dynamic correction method, a storage medium and electronic equipment for chromatograph aging, relating to the technical field of chromatographs, wherein the method comprises the following steps: acquiring a standard chromatogram; acquiring a corresponding first color spectrogram; identifying chromatographic peaks, air peaks, and continuum peaks in the first chromatogram; obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the continuous peak overlap ratio or the average value of the chromatogram peak height difference ratio of the first chromatogram; and correcting the detection chromatogram obtained by detecting the object to be detected in the corresponding detection period to obtain the corrected detection chromatogram. The method and the device are used for detecting based on a standard detection object and standard detection parameters, comparing a first chromatogram obtained by detection with a standard chromatogram obtained by detection when leaving a factory, mastering detection errors and correcting, so that the accuracy and the reliability of chromatographic detection are improved to a certain extent.

Description

Dynamic correction method for chromatograph aging, storage medium and electronic device

Technical Field

The application relates to the technical field of chromatographs, in particular to a dynamic correction method for aging of a chromatograph, a storage medium and electronic equipment.

Background

Chromatographs are widely used as chromatographic apparatuses for identifying or quantifying components in a sample. When a chromatograph analyzes a sample, a corresponding chromatogram is obtained by detection, component identification is performed based on the position of a chromatographic peak of the chromatogram, and the component is quantitatively analyzed based on the area and height of the chromatographic peak.

With the increase of the service time, the aging degree of the chromatograph will also gradually deteriorate, and the conventional correction method mostly adopts fixed correction parameters to correct the chromatograph, so that the detection error of the chromatograph cannot be more accurately compensated.

Therefore, in order to cope with a detection error caused by gradual aging of the chromatograph, a chromatograph dynamic correction technique is provided.

Disclosure of Invention

The application provides a dynamic correction method, a storage medium and electronic equipment for chromatograph aging, which are used for detecting based on a standard detection object and standard detection parameters, comparing a first chromatogram obtained by detection with a standard chromatogram obtained by detection when leaving a factory, mastering a detection error and performing correction processing, thereby improving the accuracy and reliability of chromatographic detection to a certain extent.

In a first aspect, the present application provides a method for dynamic correction of chromatograph aging, the method comprising the steps of:

obtaining a standard chromatogram obtained by detecting a standard detection object according to standard detection parameters when a chromatograph leaves a factory;

when the chromatograph finishes the detection work of the detection times corresponding to the preset detection period, extracting a first chromatogram obtained by detecting a standard detection object by the chromatograph according to standard detection parameters;

identifying whether an air peak exists in the first chromatogram, and calculating to obtain an air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in the standard chromatogram;

identifying whether continuous peaks exist in the first chromatogram, and calculating to obtain continuous peak overlapping ratios of the continuous peaks when the continuous peaks exist and only two chromatographic sub-peaks exist in the continuous peaks;

identifying the height value of the chromatographic peak in the first chromatogram, and comparing the height value with the height value of the corresponding chromatographic peak in the standard chromatogram to obtain the corresponding chromatographic peak height difference ratio value and the average value of the chromatographic peak height difference ratio value;

obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the continuous peak overlap ratio or the average of the chromatogram peak height difference ratio values of the first chromatogram;

and correcting the detection chromatogram obtained by detecting the object to be detected in the corresponding detection period of the chromatograph based on the chromatogram correction instruction to obtain the detection chromatogram after correction processing.

Specifically, in calculating and obtaining the continuous peak overlapping ratio of the continuous peaks, the method comprises the following steps:

identifying and obtaining the distance of the vertexes of two chromatographic sub-peaks in the continuous peaks on the abscissa, and recording the distance as the interval width of the continuous peaks;

identifying the distance of the continuous peak and two intersection points of the base line of the first chromatogram on the abscissa, and recording the distance as the bottom width of the continuous peak;

calculating the continuous peak overlap ratio of the continuous peaks based on the continuous peak interval width and the continuous peak bottom width.

Specifically, the chromatogram correction instruction includes a continuous peak correction instruction or a continuous peak abnormality marking instruction, and the method includes the following steps of, based on the air peak height ratio, the continuous peak overlap ratio, or the average of the chromatogram peak height difference ratio values of the first chromatogram, obtaining a corresponding chromatogram correction instruction:

comparing the continuous peak overlapping ratio with a preset continuous peak overlapping ratio threshold;

and when the continuous peak overlap ratio is not greater than the continuous peak overlap ratio threshold, generating the continuous peak correction instruction, otherwise, generating the continuous peak abnormity marking instruction.

Further, the method comprises the following steps:

and when the continuous peak exists in the first chromatogram and the chromatogram peak has at least three chromatogram sub-peaks, generating the continuous peak abnormity marking instruction.

Specifically, the method includes the following steps of identifying a height value of a chromatographic peak in the first chromatogram, comparing the height value with a height value of a corresponding chromatographic peak in the standard chromatogram to obtain a corresponding chromatographic peak height difference ratio value and a chromatographic peak height difference ratio value average value:

identifying the height value of the chromatographic peak in the first chromatographic chart and the height value of the corresponding chromatographic peak in the standard chromatographic chart, and calculating to obtain the chromatographic peak height difference corresponding to the chromatographic peak;

calculating to obtain a corresponding chromatographic peak height difference ratio based on the chromatographic peak height difference corresponding to the chromatographic peak and the height value of the corresponding chromatographic peak in the standard chromatogram;

and calculating to obtain the average value of the chromatographic peak height difference ratio based on the chromatographic peak height difference ratio.

Specifically, the chromatogram correction instruction includes a chromatogram peak maintaining instruction, a chromatogram peak correction instruction, or a chromatogram peak abnormality marking instruction, and the corresponding chromatogram correction instruction is obtained based on the air peak height ratio, the continuous peak overlap ratio, or the average of the chromatogram peak height difference ratios of the first chromatogram, and the method includes the following steps:

comparing the average value of the chromatographic peak height difference ratio with a preset threshold value of the chromatographic peak height difference ratio and a chromatographic peak height difference allowable value;

when the average value of the chromatographic peak height difference ratio is not greater than the chromatographic peak height difference permission value, generating a chromatographic peak maintaining instruction;

when the average value of the chromatographic peak height difference ratio is greater than the chromatographic peak height difference allowable value and not greater than the threshold value of the chromatographic peak height difference ratio, generating the chromatographic peak correction instruction based on the average value of the chromatographic peak height difference ratio of the first chromatographic spectrum;

and when the average value of the chromatographic peak height difference ratio is larger than the threshold value of the chromatographic peak height difference ratio, generating a chromatographic peak abnormity marking instruction.

Specifically, the chromatogram correction instruction includes an air peak elimination instruction or an air peak abnormality marking instruction, and the corresponding chromatogram correction instruction is obtained based on the air peak height ratio, the continuous peak overlap ratio, or the average value of the chromatogram peak height difference ratios of the first chromatogram, and the method includes the following steps:

comparing the air peak height ratio with a preset air peak height ratio threshold;

and when the air peak height ratio is not greater than the air peak height ratio threshold, generating the air peak eliminating instruction, otherwise, generating the air peak abnormity marking instruction.

Further, the method comprises the following steps:

counting the air peak height ratio, the continuous peak overlapping ratio or the average value of the chromatographic peak height difference ratio of the first chromatographic chart corresponding to different detection periods;

and obtaining the variation trend of the air peak height ratio, the variation trend of the continuous peak overlapping ratio or the variation trend of the average value of the chromatographic peak height difference ratio of the first chromatographic chart of the current detection period relative to the first chromatographic chart of the previous detection period based on the numerical variation of the air peak height ratio, the continuous peak overlapping ratio or the average value of the chromatographic peak height difference ratio corresponding to different detection periods.

In a second aspect, the present application provides a storage medium having stored thereon a computer program which, when executed by a processor, implements the dynamic correction method for chromatograph aging mentioned in the first aspect.

In a third aspect, the present application provides an electronic device, which includes a memory and a processor, the memory stores a computer program running on the processor, and the processor executes the computer program to implement the dynamic correction method for aging of a chromatograph according to the first aspect.

The beneficial effect that technical scheme that this application provided brought includes:

the method and the device are used for detecting based on the standard detection object and the standard detection parameters, comparing the first chromatogram obtained by detection with the standard chromatogram obtained by detection when leaving the factory, mastering the detection error changing along with the increase of the using time, and carrying out periodic correction processing based on the changed detection error, thereby improving the detection accuracy and reliability of the chromatograph to a certain extent.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic flow chart of a dynamic correction method for chromatograph aging according to an embodiment of the present application;

fig. 2 is a flowchart illustrating steps of a dynamic correction method for aging of a chromatograph according to an embodiment of the present application;

fig. 3 is a schematic diagram illustrating analysis of continuous peaks in a dynamic correction method for aging of a chromatograph provided in the first embodiment of the present application;

fig. 4 is a schematic diagram illustrating analysis of continuous peaks in a special case of a dynamic correction method for aging of a chromatograph provided in the first embodiment of the present application;

fig. 5 is a schematic analysis diagram of an air peak in a dynamic correction method for aging of a chromatograph provided in the first embodiment of the present application;

fig. 6 is a flowchart illustrating steps of a dynamic correction method for chromatograph aging according to the second embodiment of the present application.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Embodiments of the present application will be described in further detail below with reference to the accompanying drawings.

The embodiment of the application provides a dynamic correction method for chromatograph aging, a storage medium and an electronic device, detection is performed based on a standard detection object and a standard detection parameter, a first chromatogram obtained by detection is compared with a standard chromatogram obtained by detection when leaving a factory, a detection error which changes along with the increase of the use duration is mastered, and periodic correction processing is performed based on the changed detection error, so that the detection accuracy and reliability of a chromatograph are improved to a certain extent.

In order to achieve the technical effects, the general idea of the application is as follows:

a dynamic correction method for chromatograph aging, the method comprising the steps of:

s1, a preset chromatogram acquisition module acquires a standard chromatogram obtained by detecting a standard detection object according to standard detection parameters when the chromatograph leaves the factory;

s2, recording the use times of the chromatograph in real time by a preset use time counting module, and sending a first color spectrum extraction instruction to a chromatogram acquisition module by the use time counting module when the chromatograph completes the detection work of the detection times corresponding to the preset detection period, wherein the chromatogram acquisition module responds to the first color spectrum extraction instruction and extracts a first color spectrum obtained by detecting a standard detection object by the chromatograph according to standard detection parameters;

s3, identifying whether an air peak exists in the first chromatogram by a preset chromatogram identification module, and calculating to obtain an air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in the standard chromatogram when the air peak exists;

s4, the chromatogram identification module identifies whether a continuous peak exists in the first chromatogram, and when the continuous peak exists and only two chromatographic sub-peaks exist in the continuous peak, the continuous peak overlapping ratio of the continuous peak is calculated and obtained based on the top point positions of the two chromatographic sub-peaks in the continuous peak;

s5, the chromatogram identification module identifies the height value of the chromatographic peak in the first chromatogram, and compares the height value with the height value of the corresponding chromatographic peak in the standard chromatogram to obtain the corresponding chromatographic peak height difference ratio and the average value of the chromatographic peak height difference ratio;

s6, the chromatogram identification module obtains a corresponding chromatogram correction instruction based on the air peak height ratio, the continuous peak overlapping ratio or the average value of the chromatogram peak height difference ratio of the first chromatogram;

s7, the preset chromatogram processing module corrects a detection chromatogram obtained by detecting the object to be detected by the chromatogram in the corresponding detection period based on the chromatogram correction instruction, and a detection chromatogram after correction processing is obtained; wherein the content of the first and second substances,

the chromatogram correction instruction comprises an air peak eliminating instruction, an air peak abnormity marking instruction, a continuous peak correction instruction, a continuous peak abnormity marking instruction, a chromatographic peak correction instruction, a chromatographic peak abnormity marking instruction or a chromatographic peak maintaining instruction.

It should be noted that, in the embodiment of the present application, a standard detection object database is configured correspondingly to the standard detection object, one substance is selected from the standard detection object database as the standard detection object, or at least two substances are selected as two different standard detection objects respectively, the standard detection object database includes a specific substance or a plurality of different substances, and standard chromatograms corresponding to the various standard detection objects are recorded correspondingly;

when the standard detection substance has a plurality of types and corresponds to a plurality of different substances, the standard detection substance can be selected according to the actual material condition or the actual requirement during specific operation so as to correspond to different actual conditions.

In the specific operation, a standard detection object can be selected for one-time detection to obtain a first chromatogram,

can select a standard detection object to carry out multiple detections, obtain a plurality of first color spectrograms, obtain an error average value based on the plurality of first color spectrograms, carry out corresponding processing work on the error average value,

at least two standard detection objects are selected for one-time detection to obtain at least two first color spectrograms, an error average value is obtained based on the at least two first color spectrograms, corresponding processing work is carried out on the error average value,

or at least two standard detection substances are selected to be respectively detected for at least two times to obtain a plurality of first color spectrograms, an error average value is obtained based on the plurality of first color spectrograms, and the error average value is subjected to corresponding processing work.

Of course, when step S1 is executed, several or all kinds of different substances may be selected and detected to obtain a corresponding first chromatogram, and then compared with the standard chromatograms corresponding to the various substances to obtain the air peak height ratio, the continuous peak overlap ratio, the chromatogram peak height difference ratio and the chromatogram peak height difference ratio average value corresponding to each substance,

then based on the air peak height ratio, continuous peak overlapping ratio, chromatographic peak height difference ratio and chromatographic peak height difference ratio average value which are respectively corresponding to each substance, calculating to obtain the current working state of the chromatograph, namely the integral air peak height ratio average value, the integral continuous peak overlapping ratio average value and the integral chromatographic peak height difference ratio average value which are corresponding to the current aging degree,

and finally, obtaining a chromatogram correction instruction corresponding to the chromatograph based on the average value of the integral air peak height ratio, the average value of the integral continuous peak overlapping ratio and the average value of the integral chromatographic peak height difference ratio.

The reference detection parameter may be a chromatograph operation parameter at the time of performing the chromatographic detection and a setting parameter at the time of the corresponding detection operation, which are set in advance for performing the dynamic correction.

The substance to be detected is a substance which needs to be subjected to chromatographic detection by a chromatograph in daily detection work.

An air peak refers to a chromatographic peak formed when air or other substances enter a chromatograph, and generally appears before the first chromatographic peak of a chromatogram obtained by the chromatograph for detecting an object to be detected.

By continuous peaks is meant that adjacent portions of at least two chromatographic peaks coincide such that there are at least 2 peaks and 1 valley of the continuous peaks, in the examples herein chromatographic peaks within the continuous peaks are denoted as chromatographic sub-peaks.

In addition, the standard chromatogram obtained by detecting the standard test substance according to the standard detection parameters at the time of shipment of the chromatograph can be understood as a standard chromatogram which is obtained by detecting the standard test substance at the initial time, that is, a new chromatograph, and in this case, it can be considered that the chromatograph in this state is free from the problem of aging, and therefore, the standard chromatogram can be compared as standard data.

The first chromatogram is obtained by performing chromatographic detection on the chromatograph in the corresponding equipment state after the chromatograph is used for the corresponding times and the corresponding detection period is completed, and the first chromatogram is obtained by detecting the standard detection object according to the standard detection parameters like the standard chromatogram, so that the difference between the first chromatogram and the standard chromatogram can reflect the detection error of the chromatograph in the corresponding equipment state, and the aging degree of the chromatograph can be reflected from the side surface.

In addition, the air peak abnormity marking instruction or continuous peak abnormity marking instruction or chromatographic peak abnormity marking instruction can be used for considering that the detection chromatogram map with the corresponding abnormity mark has a high probability of having corresponding abnormity in actual operation, and can be further identified when necessary, namely the abnormity mark at the moment can be used as screening work of later-stage accurate abnormity identification, so that the workload of the later-stage accurate abnormity identification can be reduced, and the working efficiency is improved.

The first embodiment is as follows:

referring to fig. 1 to 5, an embodiment of the present application provides a dynamic correction method for aging of a chromatograph, and the embodiment of the present application operates based on a standard detector, and the method includes the following steps:

Based on the technical scheme of the embodiment of the application, the specific operation flow is as follows:

firstly, a preset chromatogram acquisition module acquires a standard chromatogram obtained by detecting a standard detection object according to standard detection parameters when a chromatograph leaves a factory;

the standard chromatogram is used as a data basis for judging the detection error of the chromatograph.

Secondly, after the chromatograph is delivered for daily use, a preset use frequency counting module records the use frequency of the chromatograph in real time, and generates a first chromatograph extraction instruction when the chromatograph finishes the detection work of the detection frequency corresponding to the preset detection period,

the chromatogram acquisition module executes a first chromatogram extraction instruction, and extracts a first chromatogram obtained by detecting the standard detection object by the chromatograph at the corresponding moment according to the standard detection parameters;

the first chromatogram is a chromatogram obtained by detecting the aging degree of the chromatograph after the corresponding detection times, and can embody the chromatographic detection performance of the chromatograph under different aging degrees.

For example, the following steps are carried out: assuming that the detection frequency corresponding to one detection period is 1000 times, the chromatograph generates a first chromatogram extraction instruction by using a frequency statistic module after performing 1000 detection operations on different objects to be detected in a daily detection operation,

of course, the number of times corresponding to one detection period may also be set to 2000 times or 3000 times or more;

performing cyclic operation, namely extracting a first color spectrum corresponding to the chromatograph at a corresponding moment every 1000 detection operations of the chromatograph in daily detection operations, wherein the error condition of the chromatograph at the moment can be reflected by the error condition after the first color spectrum is compared with the standard chromatogram;

it should be noted that, the obtained chromatogram correction instruction is also used to correct the detection chromatogram obtained by detecting the object to be detected for 1000 times in the period, so as to obtain the detection chromatogram after the correction processing.

Thirdly, a preset chromatogram identification module identifies whether the extracted first chromatogram has an air peak, and when the air peak exists, the height of each chromatogram peak in the standard chromatogram is compared, the minimum value of the height of the chromatogram peak in the standard chromatogram is screened out, and then the height of the air peak is obtained;

a preset chromatogram identification module calculates and obtains an air peak height ratio of the air peak height to the minimum value of the chromatogram peak heights in the standard chromatogram;

because the first chromatogram may have a detection error, a certain deviation may exist in the height of the chromatographic peak in the first chromatogram, so that the relative height of the air peak and the standard chromatogram can be grasped by obtaining the air peak height ratio through the step, and the actual height of the air peak in the first chromatogram can be known.

Fourthly, because the continuous peaks belong to an abnormal condition in the chromatogram, a targeted correction is needed,

the chromatogram identification module is used for identifying whether continuous peaks exist in the first chromatogram firstly and identifying a plurality of chromatogram sub-peaks existing in the continuous peaks when the continuous peaks exist;

when only two chromatographic sub-peaks exist in the continuous peak, the chromatogram identification module identifies and obtains the vertex positions of the two chromatographic sub-peaks in the continuous peak to obtain the coordinates corresponding to the vertexes of the two chromatographic sub-peaks;

further, the chromatogram identification module identifies and obtains the distance of the vertexes of the two chromatographic sub-peaks on the abscissa, namely the interval width of the vertexes of the two chromatographic sub-peaks;

the chromatogram identification module calculates end points at two sides of the continuous peak, namely two intersection points with the base line, and obtains the bottom width of the continuous peak according to the interval width of the two intersection points;

finally, the chromatogram identification module calculates the ratio of the interval width of the top points of the two chromatographic sub-peaks to the bottom width of the continuous peak, so that the proportion of the overlapped part of the two chromatographic sub-peaks on the continuous peak to the continuous peak, namely the continuous peak overlapping ratio of the continuous peak, can be roughly mastered.

Fifthly, the chromatogram identification module identifies the height value of the chromatographic peak in the first chromatogram, further identifies the height value of the chromatographic peak corresponding to the chromatographic peak in the first chromatogram, calculates the height difference of the two, further obtains the corresponding chromatographic peak height difference ratio,

because the standard chromatogram is used as a standard basis, the height difference corresponding to the chromatographic peak in the first chromatogram can be obtained, and then the ratio of the height difference corresponding to the chromatographic peak in the first chromatogram to the height difference corresponding to the chromatographic peak in the standard chromatogram is calculated, so that the height error of the chromatographic peak can be known by combining the heights of different chromatographic peaks,

furthermore, based on the obtained chromatographic peak height difference ratio value corresponding to each chromatographic peak, the average value of the chromatographic peak height difference ratio value corresponding to the first chromatographic peak can be calculated, so that the average level of the chromatographic peak height error can be comprehensively known;

because different substances are detected, the number of chromatographic peaks is different, and only the chromatographic peak height difference ratio value corresponding to each chromatographic peak in the first chromatogram cannot be used as a correction basis, the average value of the chromatographic peak height difference ratio values is required.

Sixthly, the chromatogram identification module compares the air peak height ratio of the first chromatogram with a preset air peak height ratio threshold, when the air peak height ratio is greater than the air peak height ratio threshold, the chromatogram identification module judges that the height of the air peak in the first chromatogram is relatively too high and cannot be eliminated, so that an air peak abnormal marking instruction is generated, otherwise, the chromatogram identification module judges that the height of the air peak is relatively short and the error influence is not large, so that the chromatogram identification module can eliminate the air peak and generate an air peak eliminating instruction,

assuming that the threshold of the air peak height ratio is 10%, that is, the height value of the air peak cannot be higher than 10% of the minimum value of the height of the chromatographic peak in the first chromatographic peak, when the height value exceeds 10%, it is determined that the air peak is higher and cannot be eliminated, and of course, the specific value may be set according to the requirement, such as 5%, 15% or 20%, the value range of the threshold of the air peak height ratio may also be 3% to 20%, and the smaller the value of the threshold of the air peak height ratio, the better the reliability of the corrected first chromatographic spectrum;

the chromatogram identification module compares the continuous peak overlapping ratio with a preset continuous peak overlapping ratio threshold, when the continuous peak overlapping ratio is larger than the continuous peak overlapping ratio threshold, the chromatogram identification module judges that two chromatographic sub-peaks of the continuous peak overlap too much, the chromatograph detection error is large and is not suitable for correction, so that a continuous peak abnormal marking instruction is generated, otherwise, a continuous peak correction instruction is generated,

assuming that the continuous peak overlap ratio threshold is 30%, that is, the width of the continuous peak overlap cannot exceed 30% of the total width, when the continuous peak overlap ratio threshold exceeds 30%, it is determined that the degree of the continuous peak overlap is high, the error is large, and the continuous peak overlap ratio threshold is not suitable for correction, although a specific numerical value may be set according to requirements, such as 10%, 15% or 25%, the value range of the continuous peak overlap ratio threshold may also be 10% to 30%, and the smaller the numerical value of the continuous peak overlap ratio threshold is, the better the reliability of the corrected first chromatogram is;

the chromatogram identification module compares the average value of the chromatographic peak height difference ratio with a preset threshold value of the chromatographic peak height difference ratio and a chromatographic peak height difference permission value,

when the average value of the chromatographic peak height difference ratio is not greater than the chromatographic peak height difference allowable value, determining that the error of the chromatographic peak height is small and no correction is needed, thereby generating the chromatographic peak maintaining instruction,

when the average value of the chromatographic peak height difference ratio is larger than the chromatographic peak height difference allowable value and not larger than the threshold value of the chromatographic peak height difference ratio, the error of the chromatographic peak height is judged to be small but can not be ignored, and correction is needed, so that the chromatographic peak correction instruction is generated based on the average value of the chromatographic peak height difference ratio of the first chromatographic spectrum,

when the average value of the chromatographic peak height difference ratio is larger than the threshold value of the chromatographic peak height difference ratio, the chromatographic peak height error of the first chromatographic spectrum is judged to be larger, the detection error of the chromatograph is larger, the chromatograph is not suitable for correction, and the chromatographic peak abnormal marking instruction is generated,

assuming that the allowable value of chromatographic peak height difference is 3%, the threshold value of chromatographic peak height difference ratio is 10%,

when the ratio of the height difference between the chromatographic peak of the first chromatogram and the chromatographic peak in the standard chromatogram to the height of the chromatographic peak in the standard chromatogram is less than 3 percent, correction is not needed, so as to generate the chromatographic peak maintaining instruction,

when the ratio of the height difference of a chromatographic peak of a first chromatographic chart to the height of a chromatographic peak corresponding to the chromatographic peak in a standard chromatographic chart is between 3% and 10%, correction is required, so that the chromatographic peak correction instruction is generated based on the average value of the height difference ratio of the chromatographic peaks of the first chromatographic chart,

and when the ratio of the height difference of the chromatographic peak of the first chromatographic chart to the height of the chromatographic peak corresponding to the chromatographic peak in the standard chromatographic chart exceeds 10%, the detection error of the chromatograph is large, and the chromatograph is not suitable for correction to generate the chromatographic peak abnormal marking instruction.

Certainly, the values corresponding to the allowable value of chromatographic peak height difference and the threshold value of chromatographic peak height difference ratio can be set according to the requirements, the allowable value of chromatographic peak height difference can also be set to be 0.5%, 1% or 2%, the threshold value of chromatographic peak height difference ratio can also be set to be 5%, 8% or 15%,

the range of the allowed value of the chromatographic peak height difference can also be 0.5-3%, the range of the threshold value of the chromatographic peak height difference ratio can also be 5-15%, and the smaller the allowed value of the chromatographic peak height difference and the threshold value of the chromatographic peak height difference ratio, the better the reliability of the processed first chromatographic chart.

The seventh step, when a preset chromatogram processing module executes an air peak eliminating instruction, firstly identifying whether an air peak exists in a detection chromatogram, and when the air peak exists, based on a base line of the detection chromatogram and an intersection point of the air peak and the base line, adopting a correction technical means of a curve graph in the prior art to eliminate the air peak, and obtaining a corresponding corrected detection chromatogram after the execution of the air peak eliminating instruction;

when the chromatogram processing module executes the air peak abnormity marking instruction, firstly identifying whether an air peak exists in the detection chromatogram, and when the air peak exists, adding an air peak abnormity mark to the detection chromatogram by adopting a technical means related to an image marking technology in the prior art to obtain a detection chromatogram after corresponding correction processing after the air peak abnormity marking instruction is executed;

since the height condition of the air peak of the first chromatogram corresponding to the detection period is known, that is, the specific condition of the air peak of the chromatogram obtained under the working condition of the current chromatograph is known, at this time, only whether the air peak exists in the detection chromatogram needs to be identified, and if the air peak exists, the corresponding operation is executed directly according to the air peak eliminating instruction or the air peak abnormal marking instruction of the first chromatogram corresponding to the detection period;

when the chromatogram processing module executes the continuous peak correction instruction, firstly, whether continuous peaks exist in the detection chromatogram or not is identified, when the continuous peaks exist, the inclination rate is obtained based on the curve trend of the continuous peaks in the detection chromatogram, and then the coordinates of the peak highest point and the trough lowest point of the continuous peaks in the chromatogram are combined, and the correction technical means of the curve graph in the prior art is adopted, so that two chromatographic sub-peaks in the continuous peaks in the detection chromatogram can be close to the original shape as much as possible, and the detection chromatogram after the corresponding correction processing after the air peak abnormal marking instruction is executed is obtained;

when the chromatogram processing module executes the continuous peak abnormal marking instruction, firstly, whether continuous peaks exist in the detection chromatogram or not is identified, and when the continuous peaks exist, the continuous peak abnormal marking is added to the detection chromatogram by adopting the technical means related to the image marking technology in the prior art, so that the detection chromatogram after the corresponding correction processing after the continuous peak abnormal marking instruction is executed is obtained;

similarly, because the overlapping condition of the continuous peaks of the first color spectrogram corresponding to the detection period is known, that is, the overlapping degree of the continuous peaks of the chromatogram obtained under the working condition of the current chromatograph is known, at this time, only whether the continuous peaks exist in the chromatogram needs to be identified, and if the continuous peaks exist, corresponding operation is executed directly according to a continuous peak correction instruction or a continuous peak abnormal marking instruction of the first color spectrogram corresponding to the detection period;

when the chromatogram processing module executes a chromatographic peak correction instruction, the corrected height corresponding to the chromatographic peak is grasped based on the height value of each chromatographic peak in the detection chromatogram and the average value of the chromatographic peak height difference ratio value of the corresponding chromatographic peak in the first chromatogram, and the height of the corresponding chromatographic peak in the detection chromatogram is corrected by adopting a correction technical means of a curve graph in the prior art to obtain a corresponding corrected detection chromatogram after the chromatographic peak correction instruction is executed;

when the chromatogram processing module executes the chromatographic peak maintaining instruction, maintaining and detecting each chromatographic peak in the chromatogram, and obtaining a detection chromatogram after corresponding correction processing after the chromatographic peak maintaining instruction is executed;

when the chromatogram processing module executes the chromatographic peak anomaly marking instruction, a chromatographic peak anomaly marking is added to the detection chromatogram by adopting a technical means related to an image marking technology in the prior art, and the detection chromatogram after corresponding correction processing after the chromatographic peak anomaly marking instruction is executed is obtained;

similarly, since the height error of the chromatographic peak of the first chromatographic chart corresponding to the detection period is known, that is, the height error of the chromatographic peak of the chromatographic chart obtained under the working condition of the current chromatograph is known, the corresponding operation can be executed according to the chromatographic peak correction instruction, the chromatographic peak maintaining instruction or the chromatographic peak abnormal marking instruction of the first chromatographic chart corresponding to the detection period;

thereby correcting or abnormally marking the air peak, the continuous peak and the chromatographic peak of the detection chromatogram in the detection period.

In the embodiment of the application, the detection is carried out based on the standard detection object and the standard detection parameters, the first chromatogram obtained by detection is compared with the standard chromatogram obtained by detection when leaving the factory, the detection error changing along with the increase of the using time is mastered, the aging condition of the chromatograph is known, and the periodic correction processing is carried out based on the changed detection error, so that the detection accuracy and the reliability of the chromatograph are improved to a certain extent.

Specifically, whether continuous peaks exist in the first chromatogram is identified, and during actual operation, the continuous peaks can be identified by a continuous peak identification submodule in the chromatogram identification module;

calculating and obtaining the continuous peak overlapping ratio of the continuous peaks based on the vertex positions of two chromatographic peaks in the continuous peaks, wherein the method comprises the following steps:

the continuous peak identification submodule identifies and obtains the distance of the top points of two chromatographic peaks in the continuous peaks on the abscissa and records the distance as the interval width of the continuous peaks;

the continuous peak identification submodule identifies the distance between the continuous peak and two intersection points of the base line of the chromatogram on the abscissa and records the distance as the bottom width of the continuous peak;

the continuous peak identification submodule calculates and obtains the continuous peak overlapping ratio of the continuous peaks based on the continuous peak interval width and the continuous peak bottom width.

Based on the flow, the overlapping condition of the continuous peaks can be accurately mastered, so that a basis is provided for the reliability of subsequent correction work.

As shown in fig. 3 of the drawings of the specification, for convenience of presentation, it is assumed that only 1 continuous peak exists in the chromatogram, and the specific conditions are as follows:

the distance of the BD on the abscissa is the continuous peak interval width;

the distance of AE on the abscissa is the width of the bottom of the continuous peak. (ii) a

The ratio of the width of the interval between the continuous peaks divided by the width of the bottom of the continuous peaks, i.e. the overlap ratio of the continuous peaks, can be recorded as k in the specific operation_Overlap。

Specifically, the height value of the chromatographic peak in the first chromatogram is identified, and during actual operation, the height value may be identified by a chromatographic peak identification submodule in the chromatogram identification module;

the chromatographic peak identification submodule identifies the height value of the chromatographic peak in the first chromatographic chart and compares the height value with the height value of the corresponding chromatographic peak in the standard chromatographic chart to obtain the corresponding chromatographic peak height difference ratio and the average value of the chromatographic peak height difference ratio, and the method comprises the following steps:

the chromatographic peak identification submodule identifies the height value of a chromatographic peak in the first chromatographic chart and the height value of a corresponding chromatographic peak in the standard chromatographic chart, and calculates to obtain the chromatographic peak height difference corresponding to the chromatographic peak;

the chromatographic peak identification submodule calculates and obtains a corresponding chromatographic peak height difference ratio based on the chromatographic peak height difference corresponding to the chromatographic peak and the height value of the corresponding chromatographic peak in the standard chromatogram;

and the chromatographic peak identifier sub-module calculates and obtains the average value of the chromatographic peak height difference ratio based on the chromatographic peak height difference ratio.

Based on the above process, the height difference condition of the chromatographic peak can be accurately mastered, so that a basis is provided for the reliability of subsequent correction work.

It should be noted that although the continuous peaks and the air peaks also belong to chromatographic peaks, but only to abnormal chromatographic peaks, in the process of identifying chromatographic peaks, the air peaks are identified by the air peak identification submodule, the continuous peaks are identified by the continuous peak identification submodule, and the remaining conventional chromatographic peaks are identified by the chromatographic peak identification submodule.

Specifically, whether an air peak exists in the first chromatogram is identified, and during actual operation, the air peak can be identified by an air peak identification submodule in a chromatogram identification module;

and the air peak identifier module identifies whether an air peak exists in the first chromatogram, and calculates to obtain the air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in the standard chromatogram when the air peak exists.

The relative influence condition of the height of the air peak can be mastered by comparing the height of the air peak with the minimum value of the height of the chromatographic peak in the standard chromatogram, so that whether the error is small or not is judged subsequently, and the air peak is eliminated as a data basis.

In addition, in obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the consecutive peak overlap ratio, or the average of the chromatogram peak height difference ratio values of the first chromatogram, the method includes the following steps:

the air peak identification sub-module compares the air peak height ratio with a preset air peak height ratio threshold;

and the air peak identification submodule generates the air peak eliminating instruction when the air peak height ratio is not greater than the air peak height ratio threshold, and generates the air peak abnormity marking instruction otherwise.

As shown in fig. 5 of the attached drawings, for the convenience of illustration, it is assumed that only 1 chromatographic peak and 1 air peak exist in the chromatogram, and the specific conditions are as follows:

the distance between the A and the base line on the ordinate is the height of the air peak;

the distance between the B and the base line on the ordinate is the height of a chromatographic peak;

the ratio of the height of the air peak to the height of the chromatographic peak is the ratio of the height of the air peak, and during specific operation, the ratio of the height of the air peak can be recorded as k_{Height of air peak}。

Specifically, in obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the consecutive peak overlap ratio, or the average of the chromatogram peak height difference ratios of the first chromatogram, the method includes the following steps:

the continuous peak identification submodule compares the continuous peak overlapping ratio with a preset continuous peak overlapping ratio threshold;

By comparing the continuous peak overlapping ratio with the continuous peak overlapping ratio threshold, whether the abnormal condition of the continuous peak is in the correctable range can be conveniently identified, and therefore the subsequent processing mode can be conveniently judged.

After generating the continuous peak correction instruction, the chromatogram processing module processes the continuous peaks in the detected chromatogram based on the continuous peak correction instruction, and includes the following steps:

the chromatogram processing module divides the continuous peaks into a first curve, a middle curve and a second curve along the horizontal coordinate direction of the chromatogram based on detecting the wave crests and the wave troughs of the continuous peaks in the chromatogram, wherein the middle curve comprises the middle first curve and the middle second curve;

the chromatogram processing module calculates and obtains a first virtual peak bottom point based on the middle point of the middle first curve and the average slope of the middle first curve;

the chromatogram processing module calculates and obtains a second virtual peak bottom point based on the middle point of the middle second curve and the average slope of the middle second curve;

the chromatogram processing module generates a continuous peak correction instruction based on the first virtual peak bottom point and the second virtual peak bottom point; wherein the content of the first and second substances,

the first curve is a curve corresponding to the position between the lowest point on the left side of the continuous peak and the top point on the left side of the continuous peak on the continuous peak;

the middle curve is a corresponding curve between the top point on the left side of the continuous peak and the top point on the right side of the continuous peak on the continuous peak;

the second curve is a curve corresponding to the continuous peak between the top point on the right side of the continuous peak and the lowest point on the right side of the continuous peak;

the middle first curve is a curve corresponding to the continuous peak between the top point at the left side of the continuous peak and the middle lowest point of the continuous peak;

the middle second curve is a curve corresponding to the position between the lowest point in the middle of the continuous peaks and the top point on the right side of the continuous peaks.

Also, as shown in fig. 3 of the drawings of the specification, for convenience of presentation, it is assumed that only 1 consecutive peak exists in the chromatogram, as follows:

the curve corresponding to the AB section on the continuous peak is a first curve;

the curve corresponding to the BD segments on the continuous peaks is a middle curve;

the curve corresponding to the DE section on the continuous peak is a second curve;

the curve corresponding to the BC section on the continuous peak is a middle first curve;

the curve corresponding to the CD segment on successive peaks is the middle second curve.

Point F is the midpoint of the middle first curve, the slope of the dashed line 1 is the average slope of the middle first curve, based on the midpoint of the middle first curve and the average slope of the middle first curve, a first virtual extension line, i.e. the dashed line 1, is obtained, and the intersection point of the dashed line 1 and the baseline is the first virtual peak bottom point, i.e. the point H in the graph;

a point G is the middle point of the middle second curve, the slope of the dotted line 2 is the average slope of the middle second curve, a second virtual extension line, namely the dotted line 2, is obtained based on the middle point of the middle second curve and the average slope of the middle second curve, and the intersection point of the second virtual extension line and the base line is a second virtual peak bottom point, namely a point I in the graph;

and correcting a first chromatographic sub-peak in the continuous peaks based on the ABH three points, and correcting a second chromatographic sub-peak in the continuous peaks based on the IDE three points, namely splitting into two chromatographic peaks, so that operations such as chromatographic peak area calculation and the like can be carried out at a later stage.

In addition, a special case of possible continuous peaks is given, as shown in fig. 4, it can be seen that point I is close to the first chromatographic sub-peak, point H is close to the second chromatographic sub-peak, so that at this time, the first chromatographic sub-peak in the continuous peaks is corrected based on three points ABH, and after the second chromatographic sub-peak in the continuous peaks is corrected based on three points IDE, two chromatographic peaks still have an overlapping portion, and at this time, in the subsequent calculation process, the influence thereof can be ignored, and the chromatographic peaks corresponding to three points ABH and the chromatographic peaks corresponding to three points IDE are directly regarded as two mutually independent chromatographic peaks, which are used as a reference for performing operations such as chromatographic peak area calculation.

Further, the method comprises the following steps:

and when the continuous peak exists in the first chromatogram and the chromatogram peak has at least three chromatogram sub-peaks, the continuous peak identification sub-module generates the continuous peak abnormity marking instruction.

By identifying the number of the chromatographic sub-peaks, when at least 3 chromatographic sub-peaks appear, the continuous peaks are directly judged to have abnormality and cannot be repaired, so that the abnormal conditions are conveniently marked.

the chromatographic peak identification submodule compares the average value of the chromatographic peak height difference ratio with a preset threshold value of the chromatographic peak height difference ratio and a chromatographic peak height difference permission value;

when the average value of the chromatographic peak height difference ratio is not greater than the chromatographic peak height difference permission value, the chromatographic peak identification submodule generates a chromatographic peak maintaining instruction;

when the average value of the chromatographic peak height difference ratio is greater than the chromatographic peak height difference allowable value and not greater than the threshold value of the chromatographic peak height difference ratio, the chromatographic peak identification submodule generates the chromatographic peak correction instruction based on the average value of the chromatographic peak height difference ratio of the first chromatographic spectrum;

and when the average value of the chromatographic peak height difference ratio is larger than the threshold value of the chromatographic peak height difference ratio, the chromatographic peak identification submodule generates a chromatographic peak abnormality marking instruction.

The following technical means are exemplified:

assuming that the height of a certain chromatographic peak in the first chromatogram is h, the height of the chromatographic peak of the standard chromatogram corresponding to the chromatographic peak is h_{Sign board}The corresponding ratio of the height difference of the chromatographic peaks is k, and when h is less than h_{Sign board}When the temperature of the water is higher than the set temperature,

on the contrary, when h is larger than h_{Sign board}When the temperature of the water is higher than the set temperature,

when the value of k is negative;

calculating to obtain a chromatographic peak height difference ratio average value based on the chromatographic peak height difference ratio corresponding to each chromatographic peak in the first chromatographic chart, and recording the average value as k_AverageThat is, k corresponding to each chromatographic peak in the first chromatogram is summed and divided by the number of chromatographic peaks in the first chromatogram to obtain k_AverageAnd taking the average value of the chromatographic peak height difference ratio of the first chromatogram as the chromatographic peak height difference ratio of the corresponding detection chromatogram relative to the practically correct chromatogram.

The following is explained in detail for the case that the average value of the chromatographic peak height difference ratio is greater than the permissible chromatographic peak height difference value and is not greater than the threshold value of the chromatographic peak height difference ratio:

assuming that the height of a certain chromatographic peak in the detection chromatogram is H, and the height after correction corresponding to the chromatographic peak is H_CorrectionThe obtained first color spectrum height correction formula is as follows:

；

and generating the chromatographic peak correction instruction corresponding to the detection chromatogram based on a first chromatographic profile height correction formula, thereby further improving the reliability of chromatographic peak correction.

Further, the method comprises the following steps:

a preset aging degree statistic module counts the air peak height ratio, the continuous peak overlapping ratio or the average value of the chromatographic peak height difference ratio of a first chromatographic chart corresponding to different detection periods;

the preset aging degree statistical module obtains the variation trend of the air peak height ratio, the variation trend of the continuous peak overlapping ratio or the variation trend of the average value of the chromatographic peak height difference ratio of the first chromatographic chart of the current detection period relative to the first chromatographic chart of the previous detection period based on the numerical variation of the air peak height ratio, the continuous peak overlapping ratio or the average value of the chromatographic peak height difference ratio corresponding to different detection periods.

Based on the foregoing, the operation will be specifically described:

assuming that the air peak height ratio, the continuous peak overlap ratio and the average value of the chromatographic peak height difference ratio of the first chromatographic chart of the detection period corresponding to the 1 st 1000 detections are obtained through statistics in sequence,

the air peak height ratio, the continuous peak overlapping ratio and the chromatographic peak height difference ratio average value of the first chromatographic chart of the detection period corresponding to the 2 nd 1000 detections are also obtained,

and comparing the air peak height ratio, the continuous peak overlapping ratio and the average value of the chromatographic peak height difference ratio corresponding to the two first chromatographic spectrums, so as to know whether the air peak height ratio, the continuous peak overlapping ratio and the average value of the chromatographic peak height difference ratio are respectively increased or decreased, and thus obtaining the air peak height ratio variation trend, the continuous peak overlapping ratio variation trend or the chromatographic peak height difference ratio average variation trend of the first chromatographic spectrum of the current detection period relative to the first chromatographic spectrum of the previous detection period.

By analogy, when the air peak height ratio, the continuous peak overlap ratio and the average value of the chromatographic peak height difference ratio of the first chromatographic chart of the detection periods corresponding to the 1000 detections are obtained, the air peak height ratio variation trend, the continuous peak overlap ratio variation trend or the chromatographic peak height difference ratio average value variation trend can be obtained when the chromatograph is monitored in a long time period.

The preset aging degree statistical module obtains the difference value between the average value of the air peak height ratio of the first chromatographic chart in the current detection period and the average value of the air peak height ratio of the first chromatographic chart in the previous detection period based on the variation trend of the average value of the chromatographic peak height ratio, and the difference value is recorded as k_{Adjacent difference}The adjacent difference of the average value of the chromatographic peak height ratio;

and based on the average value of the chromatographic peak height ratio and the adjacent difference of the average value of the chromatographic peak height ratio, generating an adjusted chromatographic peak correction instruction corresponding to the detection chromatogram by combining a second chromatographic peak height correction formula,

that is, there is another kind of chromatogram correction instruction, that is, a post-adjustment chromatogram peak correction instruction,

the preset chromatogram processing module can correct the detection chromatogram obtained by detecting the object to be detected in the corresponding detection period by the chromatograph based on the adjusted chromatographic peak correction instruction, so as to obtain the detection chromatogram after correction processing.

It should be noted that: the detection chromatogram height correction formula is adjusted, so that the change trend can be better adapted when the height correction is carried out;

the second chromatogram height correction formula based on the adjustment of the trend of the average value of the chromatographic peak height difference ratio is as follows:

；

wherein k is_{Adjacent difference}The difference value is the difference value between the average value of the chromatographic peak height ratio of the first chromatographic spectrum of the current detection period and the average value of the chromatographic peak height ratio of the first chromatographic spectrum of the previous detection period.

In addition, in order to reduce errors, the embodiment of the present application may further perform multiple operations based on a standard detection object, and the specific operation differences in steps S1 to S7 are as follows:

in step S2: the chromatogram acquisition module responds to the first chromatogram extraction instruction, and extracts a first chromatogram obtained by detecting the standard detection object by the chromatograph according to the standard detection parameters for multiple times so as to obtain a plurality of first chromatograms;

in step S3: the preset chromatogram identification module identifies whether an air peak exists in a plurality of first chromatogram maps, and when the air peak exists, the air peak height ratio of the air peak height in each first chromatogram map to the minimum value of the chromatogram peak height in the standard chromatogram map is calculated, so that the average value of the overall air peak height ratio is calculated;

in step S4: the chromatogram identification module identifies whether continuous peaks exist in the plurality of first chromatogram patterns, and when the corresponding first chromatogram patterns have the continuous peaks and only two chromatographic sub-peaks exist in the continuous peaks, the continuous peak overlapping ratio of the corresponding continuous peaks in the first chromatogram patterns is calculated and obtained based on the top point positions of the two chromatographic sub-peaks in the continuous peaks, and further the average value of the integral continuous peak overlapping ratio is calculated and obtained;

s5, the chromatogram identification module identifies the height values of chromatographic peaks in the plurality of first chromatograms, compares the height values with the height values of corresponding chromatographic peaks in the standard chromatogram to obtain the chromatographic peak height difference ratio value and the chromatographic peak height difference ratio value average value of the corresponding first chromatograms, and further calculates to obtain the integral chromatographic peak height difference ratio value average value;

s6, the chromatogram identification module obtains corresponding chromatogram correction instructions based on the average value of the overall air peak height ratio, the average value of the overall continuous peak overlapping ratio or the average value of the overall chromatographic peak height difference ratio obtained according to the plurality of first chromatograms;

Example two:

the dynamic correction method for the aging of the chromatograph provided by the embodiment of the present application is improved on the basis of the first embodiment, and the technical content disclosed in the first embodiment should also belong to the technical content disclosed in the embodiment of the present application, and is not described herein again.

Referring to fig. 6, on the basis of the first embodiment, the present application provides a dynamic correction method for aging of a chromatograph, which is different from embodiment 1 in that the present application performs at least two detection operations based on at least two different standard detection objects, and the method includes the following steps:

s1, a preset chromatogram acquisition module acquires standard chromatograms obtained by detecting at least two standard detection objects according to standard detection parameters when the chromatograph is shipped;

s2, recording the use times of the chromatograph in real time by a preset use time counting module, and sending a first color spectrum extraction instruction to a chromatogram acquisition module by the use time counting module when the chromatograph completes the detection work of the detection times corresponding to the preset detection period, wherein the chromatogram acquisition module responds to the first color spectrum extraction instruction and extracts a first color spectrum obtained by detecting the corresponding standard detection object by the chromatograph according to standard detection parameters;

s3, a preset chromatogram identification module identifies whether an air peak exists in a first chromatogram corresponding to different standard detection objects, and when the air peak exists, the air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in the standard chromatogram is calculated and obtained, and the average value of the whole air peak height ratio is calculated and obtained;

s4, the chromatogram identification module identifies whether continuous peaks exist in different first chromatograms, and when continuous peaks exist and only two chromatographic sub-peaks exist in the continuous peaks, continuous peak overlapping ratios of the continuous peaks in the different first chromatograms are calculated and obtained based on the top point positions of the two chromatographic sub-peaks in the continuous peaks, and the average value of the integral continuous peak overlapping ratios is calculated and obtained;

s5, the chromatogram identification module identifies the height values of chromatographic peaks in different first chromatograms, compares the height values with the corresponding chromatographic peaks in the standard chromatogram to obtain corresponding chromatographic peak height difference ratios and chromatographic peak height difference ratio average values, and calculates to obtain the overall chromatographic peak height difference ratio average value;

s6, the chromatogram identification module obtains a corresponding chromatogram correction instruction based on the average value of the ratio of the height of the whole air peak, the average value of the overlapping ratio of the whole continuous peaks or the average value of the ratio of the height difference of the whole chromatogram peaks;

In the embodiment of the application, the detection is carried out based on standard detection parameters and different standard detection objects, the detection errors are subjected to average processing, random errors caused by the characteristics of different standard detection objects are reduced, the detection errors changing along with the increase of the using time length are reliably mastered, the aging condition of a chromatograph is known, and periodic correction processing is carried out based on the changed detection errors, so that the detection accuracy and reliability of the chromatograph are improved to a certain extent.

Specifically, the air peak height ratio in each first color spectrum is obtained based on the technical means in the first embodiment, and the average value is taken to obtain the average value of the overall air peak height ratio.

Specifically, after obtaining the continuous peak overlap ratio of the continuous peaks in each first chromatogram based on the technical means in the first embodiment, the continuous peak overlap ratio is counted, and an average value is taken to obtain an average value of the whole continuous peak overlap ratio.

Specifically, after obtaining the corresponding chromatographic peak height difference ratio and the average value of the chromatographic peak height difference ratio based on the technical means in the first embodiment, the average value of the chromatographic peak height difference ratios is counted, and the average value is calculated to obtain the average value of the overall chromatographic peak height difference ratio.

Specifically, in obtaining the corresponding chromatogram correction instruction based on the average value of the integral air peak height ratio, the average value of the integral continuous peak overlap ratio, or the average value of the integral chromatographic peak height difference ratio, the method includes the following steps:

the air peak identification submodule compares the average value of the integral air peak height ratio with a preset air peak height ratio threshold;

and the air peak identification submodule generates the air peak eliminating instruction when the average value of the overall air peak height ratio is not greater than the air peak height ratio threshold, and generates the air peak abnormity marking instruction otherwise.

the continuous peak identification submodule compares the integral continuous peak overlapping ratio average value with a preset continuous peak overlapping ratio threshold value;

and when the average value of the integral continuous peak overlapping ratio is not greater than the continuous peak overlapping ratio threshold, generating a continuous peak correction instruction, otherwise, generating the continuous peak abnormity marking instruction by the continuous peak identification submodule.

Further, the method comprises the following steps:

and when the continuous peak exists in any first chromatographic chart and at least three chromatographic sub-peaks exist in the chromatographic peak, the continuous peak identification sub-module generates the continuous peak abnormity marking instruction.

the chromatographic peak identification submodule compares the average value of the height difference ratio of the integral chromatographic peak with a preset threshold value of the height difference ratio of the chromatographic peak and a chromatographic peak height difference allowable value;

when the average value of the ratio of the height difference of the integral chromatographic peak is not more than the allowable value of the height difference of the chromatographic peak, the chromatographic peak identifying submodule generates a chromatographic peak maintaining instruction;

when the average value of the integral chromatographic peak height difference ratio is greater than the chromatographic peak height difference allowable value and not greater than the chromatographic peak height difference ratio threshold, the chromatographic peak identification submodule generates the chromatographic peak correction instruction based on the average value of the integral chromatographic peak height difference ratio;

and when the average value of the height difference ratio of the integral chromatographic peak is larger than the threshold value of the height difference ratio of the chromatographic peak, the chromatographic peak identification submodule generates an abnormal marking instruction of the chromatographic peak.

Based on the technical solution in the first embodiment, when the first chromatogram height correction formula is applied in the embodiment of the present application, the average value of the height difference ratio of the whole chromatogram peak is recorded as k_AverageAnd substituting the formula into a first color spectrum height correction formula.

Similarly, based on the technical scheme in the first embodiment, in the embodiment of the application, a preset aging degree statistic module is used for counting the average value of the integral air peak height ratio, the average value of the integral continuous peak overlapping ratio or the average value of the integral chromatographic peak height difference ratio corresponding to different detection periods;

the preset aging degree statistical module obtains the air peak height ratio variation trend, continuous peak overlapping ratio variation trend or chromatographic peak height difference ratio average variation trend of the current detection period relative to the previous detection period based on the integral air peak height ratio average, integral continuous peak overlapping ratio average or integral chromatographic peak height difference ratio average corresponding to different detection periods.

At this time, k in the second chromatogram height correction formula_{Adjacent difference}The difference value is the difference value between the average value of the overall chromatographic peak height ratio of the current detection period and the average value of the overall chromatographic peak height ratio of the previous detection period.

Of course, based on the technical idea of the embodiment of the present application, multiple detection operations may be performed based on multiple different standard detection objects, and subsequent detection and dynamic correction techniques are similar and will not be described herein.

Example three:

the present application provides a storage medium, on which a computer program is stored, which when executed by a processor implements the dynamic correction method for chromatograph aging mentioned in the first aspect.

Example four:

an embodiment of the present application provides an electronic device, which includes a memory and a processor, where the memory stores a computer program running on the processor, and the processor implements the dynamic correction method for aging of a chromatograph according to the first aspect when executing the computer program.

It is noted that, in the present application, relational terms such as "first" and "second", and the like, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The foregoing are merely exemplary embodiments of the present application and are presented to enable those skilled in the art to understand and practice the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A method for dynamic correction of chromatograph aging, the method comprising the steps of:

2. The dynamic correction method for chromatograph aging according to claim 1, wherein in calculating the successive peak overlap ratio of obtaining the successive peaks, the method comprises the steps of:

3. The dynamic correction method for chromatograph aging according to claim 2, wherein the chromatogram correction instruction comprises a continuous peak correction instruction or a continuous peak abnormality marking instruction, and the method comprises the following steps in obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the continuous peak overlap ratio, or the chromatogram peak height difference ratio average of the first chromatogram:

4. The method of dynamic correction for chromatograph aging of claim 2, wherein the chromatogram correction instructions comprise continuous peak correction instructions or continuous peak anomaly marking instructions, the method further comprising the steps of:

5. The dynamic correction method for aging of chromatograph of claim 1, wherein the height value of the chromatographic peak in the first chromatogram is identified and compared with the height value of the corresponding chromatographic peak in the standard chromatogram to obtain the corresponding chromatographic peak height difference ratio value and the average value of the chromatographic peak height difference ratio value, the method comprises the following steps:

6. The dynamic correction method for chromatograph aging according to claim 5, wherein the chromatogram correction instruction comprises a chromatogram peak maintaining instruction or a chromatogram peak correction instruction or a chromatogram peak abnormality marking instruction, and the method comprises the following steps in obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the consecutive peak overlap ratio or the chromatogram peak height difference ratio average of the first chromatogram:

7. The dynamic correction method for chromatograph aging according to claim 1, wherein the chromatogram correction instruction comprises an air peak elimination instruction or an air peak abnormality marking instruction, and the method comprises the following steps in obtaining a corresponding chromatogram correction instruction based on the air peak height ratio, the continuous peak overlap ratio, or the average value of the chromatogram peak height difference ratios of the first chromatogram:

8. The method for dynamic correction of chromatograph aging as recited in claim 1, further comprising the steps of:

9. A storage medium having a computer program stored thereon, characterized in that: the computer program, when executed by a processor, implements the method of any one of claims 1 to 8.

10. An electronic device comprising a memory and a processor, the memory having stored thereon a computer program that runs on the processor, characterized in that: the processor, when executing the computer program, implements the method of any of claims 1 to 8.