CN116106465B

CN116106465B - Chromatograph fault diagnosis method and device based on parameter analysis

Info

Publication number: CN116106465B
Application number: CN202310375930.4A
Authority: CN
Inventors: 王东强; 冀禹璋
Original assignee: China Spectrum Tech Beijing Technology Co ltd
Current assignee: China Spectrum Tech Beijing Technology Co ltd
Priority date: 2023-04-11
Filing date: 2023-04-11
Publication date: 2023-06-16
Anticipated expiration: 2043-04-11
Also published as: CN116106465A

Abstract

The application relates to a chromatograph fault diagnosis method and device based on parameter analysis, and relates to the technical field of chromatographs, wherein the method comprises the following steps: selecting a preset detection object and a plurality of corresponding groups of working parameter combinations; the target chromatograph analyzes a preset detection object based on a plurality of groups of working parameter combinations to obtain a plurality of corresponding initial detection chromatograms; correcting the initial detection chromatogram based on an aging correction coefficient corresponding to the current use state of the target chromatograph to obtain a corresponding corrected version chromatogram; comparing the multiple corrected version chromatograms with corresponding standard chromatograms in a database respectively to obtain error information of the multiple corrected version chromatograms; and performing fault diagnosis on the target chromatograph based on the error information of the multiple corrected versions of chromatograms. According to the method and the device, based on the combination of the preset detection object and the corresponding height working parameters, chromatographic analysis work is carried out, fault diagnosis is carried out on the target chromatograph based on chromatographic analysis results, and convenience is brought to daily maintenance work of the chromatograph.

Description

Chromatograph fault diagnosis method and device based on parameter analysis

Technical Field

The application relates to the technical field of chromatographs, in particular to a chromatograph fault diagnosis method and device based on parameter analysis.

Background

Currently, chromatographs are widely used for analysis of components in samples. With daily use, the chromatograph may cause certain equipment aging or equipment damage due to usage habit or storage environment, thereby causing certain detection errors. If obvious detection errors occur in the obtained chromatograms, analysis results with larger errors are finally obtained.

At present, the fault diagnosis of the chromatograph requires a professional to detect components of the chromatograph one by one based on professional equipment, and the operation is complex and the requirement on professional skills is high.

Therefore, in order to facilitate the user to carry out daily maintenance and management on the chromatograph, a chromatographic fault diagnosis technology is provided.

Disclosure of Invention

The utility model provides a chromatograph fault diagnosis method and device based on parameter analysis utilizes the target chromatograph that needs to carry out fault diagnosis, carries out chromatographic analysis work based on predetermineeing the thing and corresponding high operating parameter combination, carries out fault diagnosis to the target chromatograph based on chromatographic analysis result, convenient operation, and the testing result is objective reliable, can provide convenience for chromatograph routine maintenance work.

In a first aspect, the present application provides a method for fault diagnosis of a chromatograph based on parameter analysis, the method comprising the steps of:

selecting a preset detection object and a corresponding plurality of groups of working parameter combinations in a preset test database;

the target chromatograph analyzes the preset detection object based on a plurality of groups of working parameter combinations to obtain a plurality of corresponding initial detection chromatograms;

correcting the initial detection chromatogram based on the ageing correction coefficient corresponding to the current use state of the target chromatograph obtained from the test database, and obtaining a corresponding corrected version chromatogram;

comparing the corrected version chromatograms with corresponding standard chromatograms in a database respectively to obtain error information of the corrected version chromatograms;

performing fault diagnosis on the target chromatograph based on the error information of the plurality of corrected versions of chromatograms; wherein, the liquid crystal display device comprises a liquid crystal display device,

and the standard chromatogram is obtained by detecting the preset detection object according to the working parameter combination corresponding to the initial detection chromatogram by a reference chromatograph with the same model as the target chromatograph in a factory state.

Specifically, the aging correction coefficient is a chromatographic peak height correction coefficient;

The method comprises the steps of obtaining an aging correction coefficient corresponding to the current use state of the target chromatograph from the test database, correcting the initial detection chromatogram, and obtaining a corresponding corrected version chromatogram, wherein the method comprises the following steps:

based on the aging correction coefficient corresponding to the current use state of the target chromatograph obtained from the test database, correcting the chromatographic peak height of each chromatographic peak in the initial detection chromatographic chart, and obtaining the chromatographic peak corrected height corresponding to each chromatographic peak;

and correcting the initial detection chromatogram based on the corrected heights of the chromatographic peaks corresponding to the chromatographic peaks to obtain a corresponding corrected version chromatogram.

Specifically, the comparing the corrected version chromatograms with the corresponding standard chromatograms in the database to obtain error information of the corrected version chromatograms includes the following steps:

comparing the heights of the color spectrum peaks in the corrected version of color spectrum with the heights of the color spectrum peaks in the corresponding standard color spectrum in a database;

obtaining chromatographic peak height errors corresponding to each chromatographic peak in the corrected version of chromatogram;

obtaining the integral error of the chromatographic peak height corresponding to the corrected version chromatogram based on the chromatographic peak height error corresponding to each chromatographic peak in the corrected version chromatogram; wherein, the liquid crystal display device comprises a liquid crystal display device,

The corrected version chromatogram error information is the integral error of the chromatographic peak height of the corrected version chromatogram and the chromatographic peak height error corresponding to each chromatographic peak.

Specifically, the step of obtaining the integral error of the chromatographic peak height corresponding to the corrected version chromatogram based on the chromatographic peak height error corresponding to each chromatographic peak in the corrected version chromatogram comprises the following steps:

and counting the numerical median or numerical average value of the chromatographic peak height errors corresponding to each chromatographic peak in the corrected version chromatogram, and taking the corresponding numerical median or numerical average value as the overall chromatographic peak height error.

Specifically, in performing fault diagnosis on the target chromatograph based on the plurality of corrected version chromatogram error information, the method includes the following steps:

comparing the integral errors of the heights of the chromatographic peaks in the error information of the multiple corrected chromatograms with integral error thresholds of the heights of the chromatographic peaks corresponding to the corrected chromatograms respectively;

and when the ratio of the integral error of the chromatographic peak height through comparison is not larger than a preset integral error qualified ratio threshold, judging that the detection function of the target chromatograph is normal, otherwise, judging that the detection function of the target chromatograph is abnormal.

obtaining the maximum value and the minimum value of the integral error of the chromatographic peak height in the error information of the corrected version of the chromatographic peak, and respectively recording the maximum value and the minimum value of the integral error of the chromatographic peak height;

calculating the difference between the maximum value of the integral error of the chromatographic peak height and the minimum value of the integral error of the chromatographic peak height, and recording the difference as an integral error fluctuation value of the chromatographic peak height;

and when the integral error fluctuation value of the chromatographic peak height is not larger than the corresponding integral error fluctuation value threshold value of the chromatographic peak height, judging that the detection stability of the target chromatograph is normal, otherwise, judging that the detection stability of the target chromatograph is abnormal.

Further, the method further comprises a working parameter combination adjustment detection process, and the working parameter combination adjustment detection process comprises the following steps:

calculating the average value or the median of the integral error of the chromatographic peak height in the error information of the plurality of corrected chromatograms, and recording the average value or the median as a reference value of the integral error of the chromatographic peak height;

comparing the integral error of the chromatographic peak height in the error information of the corrected version of the chromatographic peak with the integral error reference value of the chromatographic peak height to obtain a corresponding error difference value;

Calculating the average value or the median of error difference values corresponding to the error information of the corrected version chromatograms, and recording the average value or the median as an error difference value reference value;

comparing error difference values corresponding to the error information of the corrected version chromatograms with the error difference value reference value to obtain error difference value comparison values;

selecting a working parameter combination with the largest absolute value in the error difference value comparison values and the absolute value larger than the error difference value comparison value threshold value, and recording the working parameter combination as a working parameter combination to be adjusted;

and generating a corresponding parameter adjustment prompt message based on the working parameter combination to be adjusted and the preset detection object.

Further, the working parameter combination adjustment detection flow further comprises the following steps:

when different target chromatographs are recorded and different preset detection objects are detected based on a plurality of groups of working parameter combinations, each working parameter combination corresponds to an error difference value comparison value of different preset detection objects;

calculating the average value or absolute value of error difference value comparison values of different preset detection objects corresponding to each working parameter combination, and recording the average value or absolute value as a working parameter combination height error influence value;

selecting a working parameter combination with the largest absolute value in the working parameter combination height error influence values and the absolute value larger than the threshold value of the working parameter combination height error influence value, and recording the working parameter combination as the working parameter combination to be adjusted;

And generating a corresponding parameter adjustment prompt message based on the working parameter combination to be adjusted.

Specifically, the integral error threshold of the chromatographic peak height and the chromatographic peak height correction coefficient are adjusted along with the use times of the target chromatograph.

In a second aspect, the present application provides a chromatograph fault diagnosis device based on parameter analysis, the device comprising:

the parameter selection module is used for selecting a preset detection object and a plurality of corresponding groups of working parameter combinations in a preset test database;

the initial detection chromatogram acquisition module is used for acquiring a plurality of corresponding initial detection chromatograms, which are obtained by analyzing the preset detection objects based on a plurality of groups of working parameter combinations of the target chromatograph;

a correction version chromatogram acquisition module for correcting the initial detection chromatogram based on the aging correction coefficient corresponding to the current use state of the target chromatograph acquired from the test database, and obtaining a corresponding correction version chromatogram;

the chromatogram error information acquisition module is used for comparing the multiple corrected version chromatograms with corresponding standard chromatograms in the database respectively to obtain multiple corrected version chromatogram error information;

A chromatograph diagnostic module for performing fault diagnosis on the target chromatograph based on a plurality of the corrected version chromatogram error information; wherein, the liquid crystal display device comprises a liquid crystal display device,

the corrected version chromatogram acquisition module is further used for correcting the chromatographic peak heights of all chromatographic peaks in the initial detection chromatogram based on the ageing correction coefficient corresponding to the current use state of the target chromatograph acquired from the test database, and obtaining the corrected chromatographic peak heights corresponding to all the chromatographic peaks;

the corrected version chromatogram acquisition module is also used for correcting the initial detection chromatogram based on the corrected heights of the chromatographic peaks corresponding to the chromatographic peaks to obtain the corresponding corrected version chromatograms.

Specifically, the chromatogram error information acquisition module is further configured to compare the heights of the respective color spectrum peaks in the corrected version of the chromatogram with the heights of the respective color spectrum peaks in the corresponding standard chromatogram in the database;

The chromatogram error information acquisition module acquires the height error of each chromatographic peak corresponding to each chromatographic peak in the corrected version chromatogram;

the chromatogram error information acquisition module acquires the integral error of the heights of the chromatographic peaks corresponding to the corrected version chromatogram based on the height error of the chromatographic peaks corresponding to the various chromatographic peaks in the corrected version chromatogram; wherein, the liquid crystal display device comprises a liquid crystal display device,

Specifically, the chromatogram error information obtaining module is further configured to count a median or an average value of values of the chromatographic peak height errors corresponding to each of the chromatographic peaks in the corrected version chromatogram, and use the median or the average value of the corresponding values as the overall error of the chromatographic peak height.

Specifically, the chromatograph diagnosis module is further configured to compare the integral errors of the heights of the chromatographic peaks in the error information of the plurality of corrected versions of chromatograms with integral error thresholds of the heights of the chromatographic peaks corresponding to the corrected versions of chromatograms respectively;

the chromatograph diagnosis module is also used for judging that the detection function of the target chromatograph is normal when the ratio of the integral error of the height of the chromatographic peak through comparison is not more than a preset integral error qualification ratio threshold value, and otherwise, judging that the detection function of the target chromatograph is abnormal.

Specifically, the chromatograph diagnosis module is further configured to obtain a maximum value and a minimum value of the overall error of the chromatographic peak height in the corrected version of chromatogram error information, and record the maximum value and the minimum value of the overall error of the chromatographic peak height as the maximum value and the minimum value of the overall error of the chromatographic peak height respectively;

the chromatograph diagnosis module is also used for calculating the difference value between the maximum value of the integral error of the chromatographic peak height and the minimum value of the integral error of the chromatographic peak height and recording the difference value as an integral error fluctuation value of the chromatographic peak height;

the chromatograph diagnosis module is further used for judging that the detection stability of the target chromatograph is normal when the integral error fluctuation value of the chromatographic peak height is not larger than the corresponding integral error fluctuation value threshold value of the chromatographic peak height, and judging that the detection stability of the target chromatograph is abnormal if the detection stability of the target chromatograph is not equal to the threshold value of the integral error fluctuation value of the chromatographic peak height.

Further, the device also comprises a working parameter combination adjustment detection module which is used for calculating the average value or the median of the integral error of the chromatographic peak height in the error information of the plurality of corrected chromatograms and recording the average value or the median as an integral error reference value of the chromatographic peak height;

the working parameter combination adjustment detection module is also used for comparing the integral error of the chromatographic peak height in the error information of the corrected version of chromatograms with the integral error reference value of the chromatographic peak height to obtain corresponding error difference values;

The working parameter combination adjustment detection module is also used for calculating the average value or the median of error difference values corresponding to the error information of the corrected version chromatograms and recording the average value or the median as an error difference value reference value;

the working parameter combination adjustment detection module is also used for comparing error difference values corresponding to the error information of the corrected version chromatograms with the error difference value reference value to obtain error difference value comparison values;

the working parameter combination adjustment detection module is also used for selecting a working parameter combination with the largest absolute value and larger absolute value than the threshold value of the error difference value comparison value in a plurality of error difference value comparison values, and recording the working parameter combination as the working parameter combination to be adjusted;

the working parameter combination adjustment detection module is also used for generating a corresponding parameter adjustment prompt message based on the working parameter combination to be adjusted and the preset detection object.

Further, the working parameter combination adjustment detection module is further used for recording error difference value comparison values of different preset detection objects corresponding to the working parameter combinations when different target chromatographs detect different preset detection objects based on a plurality of groups of working parameter combinations;

the working parameter combination adjustment detection module is also used for calculating the average value or absolute value of error difference value comparison values of different preset detection objects corresponding to each working parameter combination and recording the average value or absolute value as a working parameter combination height error influence value;

The working parameter combination adjustment detection module is also used for selecting a working parameter combination with the largest absolute value in the working parameter combination height error influence values and the absolute value larger than the threshold value of the working parameter combination height error influence value, and recording the working parameter combination as the working parameter combination to be adjusted;

the working parameter combination adjustment detection module is also used for generating a corresponding parameter adjustment prompt message based on the working parameter combination to be adjusted.

The beneficial effects that technical scheme that this application provided brought include:

according to the method, the target chromatograph which needs to be subjected to fault diagnosis is utilized, chromatographic analysis work is carried out based on the preset detection object and the corresponding height working parameter combination, fault diagnosis is carried out on the target chromatograph based on the chromatographic analysis result, the operation is convenient, the detection result is objective and reliable, and convenience can be provided for daily maintenance work of the chromatograph.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a flow chart of steps of a method for diagnosing faults of a chromatograph based on parameter analysis provided in an embodiment of the present application;

fig. 2 is a block diagram of a chromatograph fault diagnosis device based on parameter analysis provided in an embodiment of the present application.

Detailed Description

For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present application based on the embodiments herein.

Embodiments of the present application are described in further detail below with reference to the accompanying drawings.

The embodiment of the application provides a chromatograph fault diagnosis method and device based on parameter analysis, which utilizes a target chromatograph which needs to carry out fault diagnosis, carries out chromatographic analysis work based on a preset detection object and a corresponding height working parameter combination, carries out fault diagnosis on the target chromatograph based on chromatographic analysis results, is convenient to operate, has objective and reliable detection results, and can provide convenience for daily maintenance work of the chromatograph.

In order to achieve the technical effects, the general idea of the application is as follows:

a chromatograph fault diagnosis method based on parameter analysis, the method comprising the steps of:

s1, selecting a preset detection object and corresponding multi-group working parameter combinations in a preset test database;

s2, analyzing a preset detection object by the target chromatograph based on a plurality of groups of working parameter combinations to obtain a plurality of corresponding initial detection chromatograms;

s3, correcting the initial detection chromatogram based on the ageing correction coefficient corresponding to the current use state of the target chromatograph obtained from the test database, and obtaining a corresponding corrected version chromatogram;

s4, comparing the multiple corrected version chromatograms with corresponding standard chromatograms in a database respectively to obtain error information of the multiple corrected version chromatograms;

s5, performing fault diagnosis on the target chromatograph based on error information of the multiple corrected chromatograms; wherein, the liquid crystal display device comprises a liquid crystal display device,

the standard chromatogram is obtained by detecting a preset detection object according to the working parameter combination corresponding to the initial detection chromatogram by a reference chromatograph of the same model as the target chromatograph in a factory state.

In a first aspect, referring to fig. 1, an embodiment of the present application provides a fault diagnosis method for a chromatograph based on parameter analysis, including the steps of:

According to the method and the device, the target chromatograph which needs to be subjected to fault diagnosis is utilized, chromatographic analysis work is carried out based on the preset detection object and the corresponding height working parameter combination, fault diagnosis is carried out on the target chromatograph based on chromatographic analysis results, operation is convenient, the detection result is objective and reliable, and convenience can be provided for daily maintenance work of the chromatograph.

It should be noted that the working parameter combination may be, but is not limited to, one or more of mobile phase type, sample inlet temperature, detector temperature, column temperature, mobile phase flow rate, sample amount, and sample rate;

when the target chromatograph belongs to the gas chromatograph, the mobile phase flow rate is specifically the carrier gas flow rate.

Based on the steps S1 to S5, the technical scheme of the embodiment of the application operates as follows:

step S1, selecting a preset detection object in a preset test database as an object to be detected used for fault diagnosis of a target chromatograph, and selecting a plurality of groups of working parameter combinations so as to detect and obtain different chromatograms as data bases for subsequent fault diagnosis; wherein, the liquid crystal display device comprises a liquid crystal display device,

the multi-group working parameter combination specifically refers to a plurality of working parameter combinations, and each working parameter combination comprises one or more of sample inlet temperature, detector temperature, column temperature, mobile phase flow rate, sample injection quantity and sample injection speed.

Step S2, analyzing the selected preset detection objects by the target chromatograph, wherein the target chromatograph is based on different working parameter combinations, so that corresponding chromatograms are obtained respectively, and the corresponding chromatograms are convenient to identify and can be recorded as initial detection chromatograms.

In step S3, since the target chromatograph is already in use, there is a certain aging error, so the initial detection chromatogram needs to be corrected based on the aging correction coefficient corresponding to the current use state of the target chromatograph obtained from the test database, and the corresponding corrected version chromatogram is obtained.

In step S4, when comparing the plurality of corrected version chromatograms with the corresponding standard chromatograms in the database, respectively, to obtain error information of the plurality of corrected version chromatograms, the following corrected version chromatogram error information may be obtained specifically by the following method:

case one: when no air peak, continuous peak or overlapping peak exists, the corrected version chromatogram error information is a chromatogram peak height error, which specifically may be a chromatogram peak height error corresponding to each chromatogram peak in the corrected version chromatogram and the corresponding standard chromatogram, or may be an average value or median of the chromatogram peak height errors of each chromatogram peak in the corrected version chromatogram and the corresponding standard chromatogram or other parameter values capable of objectively reflecting the corrected version chromatogram and the corresponding standard chromatogram;

and a second case: when an air peak, a continuous peak or an overlapped peak exists, the correction edition chromatogram error information is a chromatogram peak height error, and meanwhile, an additional mark information is added to the correction edition chromatogram error information, on the one hand, like the above situation, the correction edition chromatogram error information can be specifically the chromatogram peak height error corresponding to each chromatogram peak in the correction edition chromatogram and the corresponding standard chromatogram, or can be an average value or median of the chromatogram peak height error of each chromatogram peak in the correction edition chromatogram and the corresponding standard chromatogram or other parameter values capable of objectively reflecting the correction edition chromatogram and the corresponding standard chromatogram,

The additional label information includes at least two parameter information, one parameter is an abnormal chromatographic peak type, which includes at least one of an air peak, a continuous peak or an overlapping peak, and the other parameter information is an abnormal chromatographic peak number parameter for indicating the number of abnormal chromatographic peaks, which may be the number of chromatographic peaks indicating the specific abnormal chromatographic peak type, i.e. how many of the air peak, the continuous peak or the overlapping peak are respectively, or may be the ratio of the number of chromatographic peaks indicating the specific abnormal chromatographic peak type, i.e. the ratio of the number of each of the air peak, the continuous peak or the overlapping peak to the total number of chromatographic peaks in the corresponding standard chromatogram.

Preferably, if necessary, in the test database, the chromatographs of different types are correspondingly provided with a plurality of preset detection objects, and in order to adapt to chromatographic analysis work of the chromatographs of corresponding types, the working parameter combinations of the different preset detection objects corresponding to the chromatographs of corresponding types are also set based on the chromatograph and the specific settings of the preset detection objects.

Specifically, the configuration of the components of the preset test object should satisfy the following conditions: when the corresponding chromatograph in a factory state and with normal performance detects the preset detection object, the obtained chromatograms have obvious mutual intervals and obvious height differences of the chromatograms, so that a sufficiently clear data basis can be obtained when fault diagnosis is carried out in the later stage;

The specific configuration of the combination of operating parameters should satisfy the following conditions: when the corresponding chromatograph in a factory state and with normal performance detects a certain preset detection object by utilizing each working parameter combination, the difference between the chromatographic analysis result in each obtained chromatogram and the component configuration of the preset detection object is within a preset error allowable range, and an air peak, a continuous peak and an overlapped peak are not caused.

In particular, the method comprises the steps of, the aging correction coefficient is a chromatographic peak height correction coefficient;

in step S3, the step of correcting the initial detection chromatogram based on obtaining an aging correction coefficient corresponding to the current usage state of the target chromatograph from the test database, and obtaining a corresponding corrected version chromatogram includes the following steps:

Specifically, step S5, in performing fault diagnosis on the target chromatograph based on the plurality of corrected version chromatogram error information, includes the following steps:

when the ratio of the integral error of the chromatographic peak height through comparison is not larger than a preset integral error qualification ratio threshold, judging that the detection function of the target chromatograph is normal, otherwise, judging that the detection function of the target chromatograph is abnormal;

the ratio of the integral error of the heights of the chromatographic peaks through comparison can be recorded as the qualified ratio of the integral error.

As described above, when there is an air peak, a continuous peak or an overlapping peak, and the corrected version chromatogram error information is a chromatogram peak height error, and an additional mark information is added to the corrected version chromatogram error information, step S5 includes the following steps in performing fault diagnosis on the target chromatograph based on a plurality of corrected version chromatogram error information:

identifying the numerical value of the abnormal chromatographic peak type in the additional mark information and the abnormal chromatographic peak quantity parameters corresponding to various abnormal chromatographic peaks;

and when the abnormal chromatographic peak type is not more than the abnormal chromatographic peak type threshold value and the abnormal chromatographic peak number parameter is not more than the abnormal chromatographic peak number parameter threshold value, judging that the detection stability of the target chromatograph is normal, otherwise, judging that the detection stability of the target chromatograph is abnormal.

Of course, since the air peak may be caused by an operation error, in order to further improve the diagnosis accuracy, step S5 may further include the steps of

When the abnormal chromatographic peak type only comprises an air peak and the abnormal chromatographic peak number parameter is not more than the abnormal chromatographic peak number parameter threshold, judging that the detection stability of the target chromatograph is normal, otherwise, judging that the detection stability of the target chromatograph is abnormal;

and when the abnormal chromatographic peak type does not comprise continuous peaks or overlapping peaks, judging that the detection stability of the target chromatograph is normal, otherwise, judging that the detection stability of the target chromatograph is abnormal.

It should be noted that, after step S5, that is, after performing fault diagnosis on the target chromatograph based on the error information of the multiple corrected versions of chromatograms, the embodiment of the present application may further include a fault factor prompting procedure, where the fault factor prompting procedure includes the following steps:

when the ratio of the integral error of the chromatographic peak height through comparison is larger than a preset integral error qualified ratio threshold, judging that the detection function of the target chromatograph is abnormal, and prompting the detection function of the chromatographic peak height of the target chromatograph to be abnormal;

when the abnormal chromatographic peak type of the corrected version chromatogram error information only comprises an air peak, prompting the chromatographic detection of a target chromatograph to generate the air peak;

and prompting the chromatographic detection of the target chromatograph to appear continuous peaks or overlapped peaks when the abnormal chromatographic peak types of the corrected version chromatogram error information comprise continuous peaks or overlapped peaks.

Based on the above technical solution, step S1 is started according to a preset fault diagnosis period in actual operation, that is, fault diagnosis is performed on the target chromatograph according to a preset diagnosis frequency;

In actual operation, the fault diagnosis period is adaptively adjusted according to the use time or error condition of the target chromatograph;

therefore, according to the technical scheme of the embodiment of the application, the fault diagnosis period adjustment flow can be configured if necessary:

setting a fault diagnosis period after the first-stage adjustment based on the number of times of use of the target chromatograph and a preset reference fault diagnosis period;

adjusting the fault diagnosis period after the first-stage adjustment based on the overall error qualified duty ratio of the target chromatograph, the overall error of the chromatographic peak height or the change rate of the overall error fluctuation value of the chromatographic peak height to obtain a fault diagnosis period after the second-stage adjustment;

and taking the fault diagnosis period after the second-stage adjustment as the updated fault diagnosis period.

Wherein, the overall error qualified duty ratio, the overall error of the chromatographic peak height or the change rate of the overall error fluctuation value of the chromatographic peak height of the target chromatograph are specifically described as follows:

assuming that fault diagnosis is performed on the target chromatograph near a plurality of fault diagnosis periods, wherein the fault diagnosis corresponding to each fault diagnosis period has corresponding overall error qualified duty ratio, chromatographic peak height overall error or chromatographic peak height overall error fluctuation value;

And obtaining a corresponding change rate based on the data difference between the overall error qualified duty ratio, the overall error of the chromatographic peak height or the overall error fluctuation value of the chromatographic peak height of the adjacent period.

Specifically, based on the number of times of use of the target chromatograph and a preset reference fault diagnosis period, a fault diagnosis period after the first-stage adjustment is set, and the specific operation is as follows:

presetting a plurality of using frequency limit values and corresponding period adjustment coefficients;

when the using times of the target chromatograph reach the corresponding using times limit value, the reference fault diagnosis period is adjusted based on the period adjustment coefficient corresponding to the using times limit value, and the corresponding fault diagnosis period after the first-stage adjustment is obtained.

Assuming that the reference fault diagnosis period is T0, the using times limit value is assumed to be 100, 200, 500 and 1000, the corresponding period adjustment coefficients are k100, k200, k500 and k1000, and the fault diagnosis period after the first-stage adjustment is marked as T1;

T1= T0* k100；

as the value of the limit value of the number of times of use increases, the value of the cycle adjustment coefficient correspondingly decreases, that is, the longer the use is, the more frequent the fault diagnosis is.

Specifically, the fault diagnosis period after the first-stage adjustment is adjusted based on the qualified ratio of the overall error of the target chromatograph, the overall error of the chromatographic peak height or the change rate of the overall error fluctuation value of the chromatographic peak height, so as to obtain the fault diagnosis period after the second-stage adjustment, and the specific operation is as follows:

When the overall error qualified duty ratio, the overall error of the chromatographic peak height or the change rate of the overall error fluctuation value of the chromatographic peak height of the target chromatograph exceeds the corresponding change threshold value, the fault diagnosis period after the first-stage adjustment is adjusted based on the corresponding period adjustment coefficient;

assuming that the fault diagnosis period after the first-stage adjustment is marked as T1, the fault diagnosis period after the second-stage adjustment is marked as T2, and the period adjustment coefficients respectively corresponding to the overall error qualified duty ratio, the overall error of the chromatographic peak height or the overall error fluctuation value of the chromatographic peak height are q1, q2 and q3;

when only the overall error qualified duty ratio exceeds the corresponding change threshold, t2= (1-q 1) ×t1;

when the rate of change of only the chromatographic peak height overall error exceeds the corresponding change threshold value, t2= (1-q 2) T1;

when the change rate of the chromatographic peak height overall error fluctuation value exceeds the corresponding change threshold value only, t2= (1-q 3) ×t1;

when the rate of change of the global error qualified duty ratio and the chromatographic peak height global error exceeds the respective corresponding change thresholds, t2= (1-q 1) × (1-q 2) × (T1)

When the rate of change of the global error qualified ratio and the chromatographic peak height global error fluctuation value exceeds the respective corresponding change threshold values, t2= (1-q 1) × (1-q 3) × (T1)

When the rate of change of the chromatographic peak height overall error and the chromatographic peak height overall error fluctuation value exceeds the respective corresponding change thresholds, t2= (1-q 2) × (1-q 3) × T1

When the rate of change of the global error qualified ratio, the global error of the chromatographic peak height and the global error fluctuation value of the chromatographic peak height all exceed the respective corresponding change thresholds, t2= (1-q 1) ×1-q 2) ×1-q 3.

Of course, in step S5, in performing fault diagnosis on the target chromatograph based on the plurality of corrected version chromatogram error information, the method may further include the following steps based on the overall error qualified duty ratio, the overall error of the chromatographic peak height, or the rate of change of the overall error fluctuation value of the chromatographic peak height:

when the overall error qualified duty ratio, the overall error of the chromatographic peak height or the change rate of the overall error fluctuation value of the chromatographic peak height of the target chromatograph exceeds the corresponding preset safety permission change rate, the detection function of the target chromatograph is judged to be abnormal, otherwise, the detection function of the target chromatograph is judged to be normal.

In a second aspect, referring to fig. 2, an embodiment of the present application provides a chromatograph fault diagnosis device based on parameter analysis, the device includes:

It should be noted that, when the chromatogram error information obtaining module specifically works, the following corrected version of chromatogram error information may be obtained specifically by the following method:

the chromatograph diagnosis module is also used for judging that the detection function of the target chromatograph is normal when the ratio of the integral error of the height of the chromatographic peak through comparison is not more than a preset integral error qualification ratio threshold value, and otherwise, judging that the detection function of the target chromatograph is abnormal;

As described above, when there is an air peak, a continuous peak or an overlapping peak, and the corrected version chromatogram error information is a chromatogram peak height error, and one additional mark information is added to the corrected version chromatogram error information, the fault diagnosis is performed on the target chromatograph based on a plurality of corrected version chromatogram error information, which comprises the following steps:

Of course, since the air peak may be caused by an operation error, in order to further improve the diagnosis accuracy, the fault diagnosis of the target chromatograph based on the plurality of corrected version chromatogram error information may further include the steps of

It should be noted that the device further includes a fault factor prompting device, which is configured to perform the following operations:

Based on the technical scheme, the chromatograph fault diagnosis device based on parameter analysis is started according to a preset fault diagnosis period in actual operation, namely, fault diagnosis is carried out on the target chromatograph according to a preset diagnosis frequency;

accordingly, the apparatus further comprises a fault diagnosis period adjustment module for performing the following operations:

T1= T0* k100；

Of course, the chromatograph diagnostic module is further configured to determine that the detection function of the target chromatograph is abnormal when the overall error qualification ratio of the target chromatograph, the overall error of the chromatographic peak height, or the variation rate of the overall error fluctuation value of the chromatographic peak height exceeds the respective corresponding preset safety allowable variation rate, and otherwise determine that the detection function of the target chromatograph is normal.

It should be noted that, the chromatograph fault diagnosis device based on parameter analysis provided in the embodiments of the present application has corresponding technical problems, technical means and technical effects, and is similar to the chromatograph fault diagnosis method based on parameter analysis in principle.

It should be noted that in this application, relational terms such as "first" and "second" and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises an element.

The foregoing is merely a specific embodiment of the application to enable one skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A method for fault diagnosis of a chromatograph based on parameter analysis, the method comprising the steps of:

2. The method for diagnosing a fault in a chromatograph based on parameter analysis as claimed in claim 1, wherein:

the aging correction coefficient is a chromatographic peak height correction coefficient;

3. The method for diagnosing a fault in a chromatograph based on parameter analysis as claimed in claim 2, wherein the steps of comparing the plurality of corrected version chromatograms with corresponding standard chromatograms in a database respectively to obtain a plurality of corrected version chromatogram error information include the steps of:

4. The method for diagnosing a fault in a chromatograph based on a parameter analysis as claimed in claim 3, wherein the step of obtaining the overall error of the heights of the chromatographic peaks corresponding to the corrected version of the chromatogram based on the error of the heights of the chromatographic peaks corresponding to the respective chromatographic peaks in the corrected version of the chromatogram comprises the steps of:

5. The method for diagnosing a fault in a chromatograph based on parameter analysis as claimed in claim 4, wherein the fault diagnosis in the target chromatograph based on a plurality of pieces of corrected version chromatogram error information comprises the steps of:

6. The method for diagnosing a fault in a chromatograph based on parameter analysis as claimed in claim 4, wherein the fault diagnosis in the target chromatograph based on a plurality of pieces of corrected version chromatogram error information comprises the steps of:

7. The method for diagnosing a fault in a chromatograph based on a parameter analysis as claimed in claim 3, wherein the method further comprises an operation parameter combination adjustment detection process, the operation parameter combination adjustment detection process comprising the steps of:

8. The method for diagnosing a fault in a chromatograph based on parameter analysis as claimed in claim 7, wherein said operation parameter combination adjustment detection procedure further comprises the steps of:

9. The method for diagnosing a fault in a chromatograph based on parameter analysis as claimed in claim 7, wherein:

and the integral error threshold value of the chromatographic peak height and the chromatographic peak height correction coefficient are adjusted along with the using times of the target chromatograph.

10. A chromatograph fault diagnosis device based on parameter analysis, characterized in that said device comprises: