CN114146741A - Precise liquid transfer device - Google Patents
Precise liquid transfer device Download PDFInfo
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- CN114146741A CN114146741A CN202010935321.6A CN202010935321A CN114146741A CN 114146741 A CN114146741 A CN 114146741A CN 202010935321 A CN202010935321 A CN 202010935321A CN 114146741 A CN114146741 A CN 114146741A
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- 239000007788 liquid Substances 0.000 title claims description 34
- 238000007789 sealing Methods 0.000 claims abstract description 78
- 230000007246 mechanism Effects 0.000 claims abstract description 9
- 238000007599 discharging Methods 0.000 claims description 19
- 238000005070 sampling Methods 0.000 claims description 18
- 239000000758 substrate Substances 0.000 claims description 11
- 230000005540 biological transmission Effects 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 9
- 230000000903 blocking effect Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000004696 Poly ether ether ketone Substances 0.000 description 4
- 229920002530 polyetherether ketone Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- -1 Polytetrafluoroethylene Polymers 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
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- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a novel precise pipettor which mainly adopts the same set of motion mechanism to realize the pipetting function and the sample taking and unloading head function, and the motion mechanism is integrated in the precise pipettor and can be used in the fields of life science instruments, in-vitro diagnostic equipment and analytical instruments. The precise pipettor consists of a linear motion module, a piston sealing module, a pump body, a sample adding head adapting module, a sample adding head dismounting module, a position sensing assembly and a base plate.
Description
Technical Field
The invention relates to a precise pipettor which can be used in the fields of life science instruments, in-vitro diagnostic equipment and analytical instruments and is used for automatically completing sample taking and unloading, sucking and beating out trace liquid.
Background
In the fields of life science instruments, in-vitro diagnostic equipment and analytical instruments, a lot of instruments need to accurately obtain trace liquid (including samples and reagents), and the volume of the liquid is from a few microliters to a few milliliters; meanwhile, in order to prevent cross contamination, it is necessary to replace the sample addition head after processing one liquid and before processing another liquid.
In view of the above application requirements, there are a number of solutions: for example, a syringe pump (or a plunger pump) and a sampling head unloading module are communicated by a pipeline, and the liquid transfer function and the sampling head unloading function are respectively completed by two sub-modules; the injection pump or the plunger pump for sucking and pumping liquid is fixed, and the sample adding head adapter and the sample adding head unloading module move at different working positions. This solution has the advantage of being easy to implement, the moving parts being small in size, but the liquid transfer accuracy is easily reduced due to the long middle line.
It is also possible to integrate the pipetting and loading head functions in one module, but to do both by two separate mechanisms. The Hamilton company of Switzerland adopts the mode that a very small direct current motor is utilized to drive a micro lead screw to move in the linear direction, and the lead screw drives a piston to move so as to realize the suction and discharge of liquid; simultaneously, utilize another motor to strain or loosen the O type circle of cover on the application of sample head adapter and application of sample head contact position, when O type circle is strained the inflation deformation, make application of sample head adapter install application of sample head and realize sealed, resume shape, application of sample head adapter and application of sample head separation when O type circle is loosened and realize unloading application of sample head. The scheme has the advantages of compact structure, high precision and high processing precision requirement and cost.
Disclosure of Invention
In view of the above problems, the present invention provides a new precision pipette, which mainly adopts an improved structure to realize the same set of motion mechanism to realize the functions of pipetting and loading/unloading sample application heads, and the motion mechanism is integrated in the precision pipette.
In order to realize the purpose of the complaint, the invention adopts the following technical scheme:
the precise pipettor consists of a linear motion module, a piston sealing module, a pump body, a sample adding head adapting module, a sample adding head dismounting module, a position sensing assembly and a substrate; the linear motion module drives the piston to move in the direction far away from the pump cavity and suck liquid into the sampling head, the linear motion module drives the piston to move in the direction entering the pump cavity and discharge the liquid out of the sampling head, and the linear motion module pushes the guide push rod of the sampling head unloading module when continuing to move forward in the direction entering the pump cavity, so that the sampling head unloading part of the sampling head unloading module is close to the sampling head and pushes the sampling head to be separated from the sampling head adapting module.
The connection relationship of the components of the precision pipettor comprises: (1) the linear motion module is arranged on the base plate through a motor flange and comprises a motor, a linear transmission assembly, a guide assembly and a linear motion part, and the linear motion part moves back and forth along the axis direction of the piston under the drive of the motor, the transmission of the linear transmission assembly and the guide of the guide assembly; or one surface of the substrate is used as a guide surface of a guide assembly of the linear motion module, and the guide surface can be a plane or a curved surface. (2) The piston is connected with the linear motion part of the linear motion module. (3) The pump cavity comprises a plurality of areas which are communicated with each other, namely a piston sealing component placing area, a piston moving area, a communicating area and a sample adding head adapting module placing area in sequence; one or more pump chambers are provided, and the number of pistons is the same as the number of pump chambers. (4) The piston sealing module is arranged in a piston sealing component placing area of the pump cavity; the piston sealing module comprises sealing elements for realizing sealing between the piston and the piston sealing assembly, sealing element accessories for realizing sealing between the sealing elements and the pump cavity and sealing element pressing plates for fixing the sealing elements in the pump cavity, and the number of the sealing elements and the sealing element accessories is the same as that of the pistons; the pump body is installed on the base plate. (5) The piston passes through the piston seal module and is coaxial with the seal of the seal module, and the piston and the pump cavity are coaxial. (6) The application of sample head adapter module is installed and is placed the region at the application of sample head adapter module of pump chamber, and application of sample head adapter module includes application of sample head adapter part and realizes sealed sealing member between application of sample head adapter part and the pump chamber. (7) When liquid is sucked, a sample adding head is installed on a sample adding head adapter of the precision pipettor, and the sample adding head adapter are sealed in an interference fit manner; when the sample adding head is inserted under the liquid level and then the linear motion module drives the piston to move towards the direction far away from the pump cavity, negative pressure formed in the pump cavity enables liquid to be sucked into the sample adding head; when the linear motion module carries the piston to move towards the direction close to the pump cavity, the positive pressure formed in the pump cavity enables the liquid to be discharged out of the sample adding head. (8) The sample adding head dismounting module consists of a pressure plate, a dismounting sample adding head part, a guide rod, guide holes and a spring, wherein the guide holes are arranged on the pump body, generally 1 or more guide holes with axes parallel to the axis of the piston are arranged, the number of the guide rods is consistent with that of the guide holes, and the guide rods penetrate through the guide holes and are connected with the dismounting sample adding head part; a spring is arranged on the guide rod, so that the guide rod pulls the unloaded sample adding head part to be close to the pump body and to be far away from the sample adding head; the pressing plate and the piston are arranged together, and when the linear motion module drives the piston to move to a certain position in the direction of entering the pump cavity and continue to move forwards, the pressing plate presses the guide rod so as to push the sample loading head unloading part to be close to the sample loading head and further push the sample loading head down from the sample loading head adapting part.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other embodiments can be obtained according to the provided drawings and embodiments without creative efforts.
Fig. 1 is a schematic view of an overall structure of a precision pipette according to an embodiment of the present invention.
Fig. 2 is a schematic view of an overall structure of a precision pipette according to another embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a sample loading head discharging module according to an embodiment of the present invention.
Fig. 4A, 4B and 4C are schematic diagrams showing the relationship of internal components in three operating states according to the embodiment of the present invention, fig. 4A is a state of a liquid sucking process, fig. 4B is a state of discharging liquid, and fig. 4C is a state of detaching a disposable sample application head.
Fig. 5A and 5B are schematic views of two structures of the piston sealing module.
The reference numbers are 1-base plate, 2-linear motion module, 201-linear motion part of linear motion module, 202-guide component of linear motion module, 3-motor flange, 4-pressing plate, 5-connecting piece, 6-piston, 7-piston sealing piece, 8-piston sealing piece accessory, 9-sealing piece pressing plate, 10-pump body, 11-sample adding head adapting piece pressing block, 12-sample adding head adapting piece, 13-sample adding head adapting piece sealing piece, 14-sample adding head dismounting part, 15-spring, 16-guide rod, 17-photoelectric blocking shaft, 18-photoelectric switch and 19-sample adding head.
Detailed Description
The core of the invention is to provide a precision pipettor, which mainly adopts an improved structure to realize the pipetting function and the loading and unloading function of the same set of motion mechanism, and the motion mechanism is integrated in the precision pipettor. .
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
According to the invention, the linear motion module 2 is connected with the piston 6, the piston 6 penetrates through the piston sealing piece 7 in the pump cavity of the pump body 10, when the piston 6 moves in the direction away from the pump cavity, liquid is sucked into the sample adding head 19, when the piston 6 moves in the direction entering the pump cavity, liquid is discharged out of the sample adding head 19, and when the piston 6 continues to move, the pressure plate 4 pushes the guide rod 16, so that the sample removing and sample adding head part 14 connected with the guide rod 16 pushes the sample adding head 19 to separate from the sample adding head adapter 12. Namely, the functions of liquid transfer and sample loading and unloading are realized through a set of linear motion components.
The same or different position sensing components may be used in different embodiments of the invention. The position sensing component may be the photoelectric barrier shaft 17 and the photoelectric switch 18.
In different embodiments of the present invention, the piston seal 7 is made of a wear-resistant material, and the material of the piston seal 7 may be polyether ether ketone (PEEK), polyurethane, or Polytetrafluoroethylene (PTFE), fluorine-containing rubber, or silicone rubber.
In different embodiments of the present invention, the piston 6 is made of a wear-resistant and high-strength material, and the piston material may be ceramic or metal.
In different embodiments of the present invention, the pump body 10 is made of a metal or non-metal material, and the pump body material may be polyetheretherketone, or organic glass, polyoxymethylene, polymethylmethacrylate, polycarbonate, or stainless steel.
In various embodiments of the present invention, the outer circumferential surface of the piston 6 and the inner circumferential surface of the piston sealing member 7 form a sealing fit through a size fit, which may be a clearance fit, a zero clearance fit, or an interference fit.
In the embodiment of the invention adopting rubber or polyurethane material as the material of the piston sealing element 7, the diameter of the outer cylindrical surface of the piston 6 is equal to or larger than that of the inner cylindrical surface of the piston sealing element 7, and the difference between the diameter of the outer cylindrical surface of the piston 6 and the diameter of the inner cylindrical surface of the piston sealing element 7 can be 0-1 mm.
In the embodiment of the invention adopting the polyether-ether-ketone material as the material of the piston sealing element 7, the diameter of the cylindrical surface of the outer circle of the piston 6 is smaller, equal or larger than that of the cylindrical surface of the inner circle of the piston sealing element 7, and the difference between the diameter of the cylindrical surface of the outer circle of the piston 6 and the diameter of the cylindrical surface of the inner circle of the piston sealing element 7 can be-0.05-0.1 mm.
Fig. 1 shows an embodiment of the present invention, a precision pipette is composed of a substrate 1, a linear motion module 2 (including a linear motion part 201 of the linear motion module and a guide assembly 202 of the linear motion module), a motor flange 3, a pressing plate 4, a connector 5, a piston 6, a piston sealing module (including a piston sealing member 7, a piston sealing member attachment 8 and a sealing member pressing plate 9), a pump body 10, a sample application head adapting module (including a sample application head adapter 12, a sample application head adapter sealing member 13 and a sample application head adapter pressing block 11), a sample application head removing module (including the pressing plate 4, a sample application head removing part 14, a spring 15 and a guide rod 16), a photoelectric switch assembly (including a photoelectric barrier shaft 17 and a photoelectric switch 18), and a sample application head 19. The connection relationship of each component comprises: the linear motion module 2 is connected to the substrate 1 through a motor flange 3, and a guide assembly 202 of the linear motion module 2 is in contact with one surface of the substrate 1 parallel to the axis direction of the piston 6 and slides back and forth along the axis direction of the piston 6 to guide a linear motion part 201 of the linear motion module 2 so that the piston 6 moves back and forth along the axis direction of the piston; the linear motion part 201 of the linear motion module 2 passes through the through hole of the pressure plate 4 to be connected with the connecting piece 5, and the piston 6 is connected with the connecting piece 5, so as to connect the piston 6 with the linear motion part 201 of the linear motion module 2, or the connecting piece 5 can be eliminated, and the linear motion part 201 of the linear motion module 2 passes through the through hole of the pressure plate 4 to be directly connected with the piston 6; the pump body 10 is provided with a pump cavity, the pump cavity comprises a plurality of mutually communicated regions, namely a piston sealing assembly placing region, a piston moving region, a communicating region and a sample adding head adapting module placing region, the regions are mutually communicated, one or more pump cavities are provided, and the number of the pistons is the same as that of the pump cavity and that of the sample adding head adapting modules; the piston seal assembly comprises the piston seal 7 and the piston seal attachment 8, the seal pressing plate 9 presses the piston seal assembly in the piston seal assembly placing area of the pump cavity, the piston 6 passes through the piston seal 7 and realizes sealing by size fit, the piston seal attachment 8 is installed between the piston seal 7 and the pump cavity and realizes sealing between the piston seal 7 and the pump cavity by size fit, or the piston seal assembly only has the piston seal 7, the seal pressing plate 9 presses the piston seal 7 in the piston seal assembly placing area of the pump cavity, the piston 6 passes through the piston seal 7 and realizes sealing between the piston seal 7 and the pump cavity through size matching, and the piston seal 7 and the pump cavity realize sealing between the piston seal 7 and the pump cavity through size matching; the sample application head adapter module comprises the sample application head adapter 12, the sample application head adapter sealing piece 13 and the sample application head adapter pressing block 11, the sample application head adapter sealing piece 13 is installed between the sample application head adapter 12 and the pump cavity of the pump body 10 and realizes sealing, and the sample application head adapter 12 and the sample application head adapter sealing piece 13 are pressed into the sample application head adapter module placing area of the pump cavity through the sample application head adapter pressing block 11; the sample adding head 19 is arranged on the sample adding head adapter 12 and sealed through size matching between the sample adding head and the sample adding head adapter; when the sample adding head 19 is inserted under the liquid level, the pump cavity forms a closed space, when the linear motion part 201 of the linear motion module 2 is guided by the guide assembly 202 to push the piston 6 to move along the direction away from the pump cavity, negative pressure is formed in the pump cavity, and liquid is sucked into the sample adding head, and when the linear motion part 201 of the linear motion module 2 is guided by the guide assembly 202 to push the piston 6 to move along the direction entering the pump cavity, positive pressure is formed in the pump cavity, and liquid is discharged out of the sample adding head; the sample loading head discharging module comprises the pressure plate 4, the sample loading head discharging part 14, the spring 15 and the guide rod 16, the guide rod 16 passes through the hole of the pump body 10 to be connected with the sample loading head discharging part 14, the spring 15 is arranged between the head of the guide rod and the pump cavity, when the pressure plate 4 is not contacted with the guide rod 16, the head of the guide rod 16 is jacked up relative to the pump body 10 by the spring 15, the sample loading head discharging part 14 is close to the pump body 10 and far away from the sample loading head 19, when the linear motion part 201 of the linear motion module 2 pushes the piston 6 to move continuously along the direction entering the pump cavity under the guide of the guide assembly 202 until the pressure plate 4 is contacted with the guide rod 16 and pushes the guide rod 16 to move continuously downwards, the guide rod 16 pushes the sample loading head discharging part 14 to move away from the pump body 10 and close to the sample loading head 19, Finally, the sample application head 19 is detached from the sample application head adapter 12; the photoelectric switch combination comprises the photoelectric blocking shaft 17 and the photoelectric switch 18, the photoelectric blocking shaft 17 is installed on the pressing plate 4, the photoelectric switch 18 is installed on the substrate 1, and when the linear motion part 201 of the linear motion module 2 moves in a linear direction under the guidance of the guide assembly 202 to a position where the photoelectric blocking shaft 17 just blocks the photoelectric signal of the photoelectric switch 18, and the position is used as the reference position of the piston 6.
Fig. 2 shows another embodiment of the present invention, the precision pipette is composed of a substrate 1, a linear motion module 2 (including a linear motion part 201 of the linear motion module), a motor flange 3, a pressing plate 4, a connecting member 5, a piston 6, a piston sealing module (including a piston sealing member 7, a piston sealing member attachment 8, and a sealing member pressing plate 9), a pump body 10, a sample application head adapting module (including a sample application head adapter 12, a sample application head adapter sealing member 13, and a sample application head adapter pressing block 11), a sample application head removing module (including the pressing plate 4, a sample application head removing part 14, a spring 15, and a guide rod 16), a photoelectric switch assembly (including a photoelectric shielding shaft 17 and a photoelectric switch 18), and a sample application head 19. The connection relationship of each component comprises: the linear motion module 2 is connected to the substrate 1 through a motor flange 3, and a guide assembly is arranged in the linear motion module 2 to guide a linear motion part 201 of the linear motion module 2 so that the piston 6 moves back and forth along the axis direction of the piston; the linear motion part 201 of the linear motion module 2 passes through the through hole of the pressure plate 4 to be connected with the connecting piece 5, and the piston 6 is connected with the connecting piece 5, so as to connect the piston 6 with the linear motion part 201 of the linear motion module 2, or the connecting piece 5 can be eliminated, and the linear motion part 201 of the linear motion module 2 passes through the through hole of the pressure plate 4 to be directly connected with the piston 6; the pump body 10 is provided with a pump cavity, the pump cavity comprises a plurality of mutually communicated regions, namely a piston sealing assembly placing region, a piston moving region, a communicating region and a sample adding head adapting module placing region, the regions are mutually communicated, one or more pump cavities are provided, and the number of the pistons is the same as that of the pump cavity and that of the sample adding head adapting modules; the piston seal assembly comprises the piston seal 7 and the piston seal attachment 8, the seal pressing plate 9 presses the piston seal assembly in the piston seal assembly placing area of the pump cavity, the piston 6 passes through the piston seal 7 and realizes sealing by size fit, the piston seal attachment 8 is installed between the piston seal 7 and the pump cavity and realizes sealing between the piston seal 7 and the pump cavity by size fit, or the piston seal assembly only has the piston seal 7, the seal pressing plate 9 presses the piston seal 7 in the piston seal assembly placing area of the pump cavity, the piston 6 passes through the piston seal 7 and realizes sealing between the piston seal 7 and the pump cavity through size matching, and the piston seal 7 and the pump cavity realize sealing between the piston seal 7 and the pump cavity through size matching; the sample application head adapter module comprises the sample application head adapter 12, the sample application head adapter sealing piece 13 and the sample application head adapter pressing block 11, the sample application head adapter sealing piece 13 is installed between the sample application head adapter 12 and the pump cavity of the pump body 10 and realizes sealing, and the sample application head adapter 12 and the sample application head adapter sealing piece 13 are pressed into the sample application head adapter module placing area of the pump cavity through the sample application head adapter pressing block 11; the sample adding head 19 is arranged on the sample adding head adapter 12 and sealed through size matching between the sample adding head and the sample adding head adapter; when the sample adding head 19 is inserted under the liquid level, the pump cavity forms a closed space, when the linear motion part 201 of the linear motion module 2 pulls the piston 6 to move along the direction far away from the pump cavity, negative pressure is formed in the pump cavity, liquid is sucked into the sample adding head, and when the linear motion part 201 of the linear motion module 2 pushes the piston 6 to move along the direction entering the pump cavity, positive pressure is formed in the pump cavity, and liquid is discharged out of the sample adding head; the sample loading head discharging module comprises the pressure plate 4, the sample loading head discharging part 14, the spring 15 and the guide rod 16, the guide rod 16 passes through the hole of the pump body 10 to be connected with the sample loading head discharging part 14, the spring 15 is arranged between the head of the guide rod and the pump cavity, when the pressure plate 4 is not contacted with the guide rod 16, the head of the guide rod 16 is jacked up relative to the pump body 10 by the spring 15, the sample loading head discharging part 14 is close to the pump body 10 and far away from the sample loading head 19, when the linear motion part 201 of the linear motion module 2 pushes the piston 6 to continue to move along the direction entering the pump cavity until the pressure plate 4 is contacted with the guide rod 16 and pushes the guide rod 16 to continue to move downwards, the guide rod 16 pushes the sample loading head discharging part 14 to far away from the pump body 10 and close to the sample loading head 19, Finally, the sample application head 19 is detached from the sample application head adapter 12; the photoelectric switch combination comprises the photoelectric blocking shaft 17 and the photoelectric switch 18, the photoelectric blocking shaft 17 is installed on the pressing plate 4, the photoelectric switch 18 is installed on the substrate 1, and when the linear motion part 201 of the linear motion module 2 moves along the linear direction to a position where the photoelectric blocking shaft 17 just blocks the photoelectric signal of the photoelectric switch 18, the position is used as the reference position of the piston 6.
Fig. 3 is a schematic structural diagram of a sample loading head discharging module according to an embodiment of the present invention, where the sample loading head discharging module includes the pressing plate 4, the discharging sample loading head part 14, the spring 15, and the guide rod 16. The internal connection relationship includes: the sample adding head dismounting module is arranged on the pump body 10; the sample unloading and loading head part 14 comprises 1 or more through holes and a plurality of mounting holes, the sample loading head adapter 12 passes through the through holes, the inner diameter of the through holes is smaller than the outer diameter of the sample loading head 19, the number of the through holes is the same as the number of the sample loading head adapters 12, and the guide rods 16 are connected to the mounting holes of the sample unloading and loading head part 14; the pump body 10 is provided with a step hole, the guide rod 16 penetrates through the through hole part of the step hole on the pump body 10, the tail end of the guide rod 16 is provided with a thread and is connected with the sample unloading head part 14, the head part of the guide rod 16 is provided with a section of rod body with a diameter larger than that of the rod body, and the spring 15 is arranged between the head part of the guide rod 16 and the step hole on the pump body 10; under the action of the spring 15, the head of the guide rod 16 is far away from the pump body 10, and the unloaded loading head part 14 and the pump body 10 are close to and far away from the loading head 19; when the linear motion part 201 of the linear motion module 2 pushes the piston 6 to move continuously in the direction of entering the pump cavity until the pressing plate 4 contacts the guide rod 16 and pushes the guide rod 16 to move continuously downwards, the guide rod 16 pushes the sample-removing head part 14 away from the pump body 10 and close to the sample-removing head 19, and finally the sample-removing head 19 is removed from the sample-removing head adapter 12.
Fig. 4A, 4B and 4C are schematic diagrams showing the relationship of internal components in three operating states according to the embodiment of the present invention, fig. 4A is a state of a liquid sucking process, fig. 4B is a state of discharging liquid, and fig. 4C is a state of detaching a disposable sample application head.
Fig. 5A is a schematic structural diagram of the piston sealing module. The piston seal module includes a piston seal 7, a piston seal attachment 8, and a seal press plate 9. The connection relation includes: the piston seal member 7 and the piston seal member attachment 8 are mounted in the pump chamber in the pump body 10 in the piston seal assembly placement area, the piston seal member attachment 8 is on the outer circumferential surface of the piston seal member 7, the piston seal member attachment 8 is used for sealing between the piston seal member 7 and the pump body 10, and the piston seal member 7 is used for sealing between the piston seal member 7 and the piston 6; and presses the piston seal 7 with the seal press plate 9.
Fig. 5B is another structural schematic diagram of the piston sealing module. The piston seal module comprises a piston seal 7 and a seal press plate 9. The connection relation includes: the piston seal 7 is mounted in the area of the pump chamber in the pump body 10 where the piston seal assembly is located, the piston seal 7 being used to effect a seal between the piston seal 7 and the pump body 10 and a seal between the piston seal 7 and the piston 6; and presses the piston seal 7 with the seal press plate 9.
Claims (7)
1. A precision pipette, characterized by:
the precise pipettor consists of a linear motion module, a piston sealing module, a pump body, a sample adding head adapting module, a sample adding head dismounting module, a position sensing assembly and a substrate; the linear motion module drives the piston to move in the direction far away from the pump cavity and suck liquid into the sampling head, the linear motion module drives the piston to move in the direction entering the pump cavity and discharge the liquid out of the sampling head, and the linear motion module pushes a guide push rod of the sampling head discharging module when continuing to move forward in the direction entering the pump cavity, so that a part of the sampling head discharging module discharging the sampling head is close to the sampling head and pushes the sampling head to be separated from the sampling head adapting module; the same set of motion mechanism realizes the functions of liquid transferring and sample loading and unloading, and the motion mechanism is integrated in the precise liquid transferring device.
2. The precision pipette of claim 1, wherein:
the linear motion module is arranged on the base plate through a motor flange and comprises a motor, a linear transmission assembly, a guide assembly and a linear motion part, the linear motion part of the linear motion module is directly connected with the piston or connected through a connecting piece, and the linear motion part moves back and forth along the axial center direction of the piston under the drive of the motor, the transmission of the linear transmission assembly and the guide of the guide assembly; or one surface of the substrate is used as a guide surface of a guide assembly of the linear motion module, and the guide surface can be a plane or a curved surface.
3. A precision pipette as defined in claim 1 or 2, wherein:
and a sealing fit is formed between the outer circular surface of the piston and the inner circular surface of the piston sealing element through a size fit, and the size fit can be a clearance fit, a zero clearance fit or an interference fit.
4. A precision pipette as defined in claim 1, 2 or 3 wherein:
the pump body has the pump chamber, the pump chamber includes a plurality of regions that communicate each other, places region, piston motion region, intercommunication region and application of sample head adapter module for piston seal assembly in proper order and places the region, each region communicates each other, the pump chamber has one or more, the quantity of piston with the quantity of pump chamber, the quantity of application of sample head adapter module is the same.
5. The precision pipette of claim 4, wherein:
the piston seal assembly comprises the piston seal and the piston seal attachment, the seal pressing plate presses the piston seal assembly in the piston seal assembly placement area of the pump chamber, the piston passes through the piston seal and is sealed by size fit between the piston seal and the piston seal attachment, the piston seal attachment is installed between the piston seal and the pump chamber and is sealed by size fit between the piston seal and the pump chamber; or the piston sealing assembly only comprises the piston sealing element, the sealing element pressing plate presses the piston sealing element in the piston sealing assembly placing area of the pump cavity, the piston penetrates through the piston sealing element, the piston sealing element and the piston sealing element are sealed through size matching, and the piston sealing element and the pump cavity are sealed through size matching.
6. The precision pipette of claim 4, wherein:
the application of sample head adapter module includes application of sample head adapter spare sealing member with application of sample head adapter spare compact heap, application of sample head adapter spare sealing member is installed application of sample head adapter spare with the pump body between the pump chamber and realize sealed, through application of sample head adapter spare compact heap will application of sample head adapter spare sealing member impress the pump chamber in application of sample head adapter module places the region.
7. A precision pipette as defined in claim 1 or 2, wherein:
the sample adding head dismounting module comprises the pressing plate, the dismounted sample adding head part, the spring and the guide rod; the internal connection relationship includes: the sample adding head dismounting module is arranged on the pump body; the sample unloading and loading head part comprises 1 or a plurality of through holes and a plurality of mounting holes, the sample loading head adapter penetrates through the through holes, the inner diameter of each through hole is smaller than the outer diameter of the sample loading head, the number of the through holes is the same as that of the sample loading head adapter, and the guide rods are connected to the mounting holes of the sample unloading and loading head part; the pump body is provided with a step hole, the guide rod penetrates through the through hole part of the step hole on the pump body, the tail end of the guide rod is provided with threads and is connected with the sample loading head removing part, the head part of the guide rod is provided with a section of rod body with a diameter larger than that of the rod body, and the spring is arranged between the head part of the guide rod and the step hole on the pump body; under the action of the spring, the head part of the guide rod is far away from the pump body, and the sample unloading head part and the pump body are close to and far away from the sample unloading head; when the linear motion part of the linear motion module pushes the piston to continue moving along the direction of entering the pump cavity until the pressing plate is contacted with the guide rod and pushes the guide rod to continue moving downwards, the guide rod pushes the sample unloading head part to be far away from the pump body and to be close to the sample loading head, and finally the sample loading head is unloaded from the sample loading head adapter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010935321.6A CN114146741A (en) | 2020-09-08 | 2020-09-08 | Precise liquid transfer device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010935321.6A CN114146741A (en) | 2020-09-08 | 2020-09-08 | Precise liquid transfer device |
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| CN114146741A true CN114146741A (en) | 2022-03-08 |
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| CN202010935321.6A Pending CN114146741A (en) | 2020-09-08 | 2020-09-08 | Precise liquid transfer device |
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| CN214261937U (en) * | 2020-09-08 | 2021-09-24 | 沈馨儿 | Precise liquid transfer device |
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| CN101279297A (en) * | 2008-04-22 | 2008-10-08 | 江苏大学 | Multichannel electronic liquor-transferring system with standard signal interface |
| CN103691498A (en) * | 2014-01-06 | 2014-04-02 | 广州市刑事科学技术研究所 | Liquid-moving machine and method of moving liquid by same |
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