CN218962674U - Pipettor and pipetting device - Google Patents

Abstract

A pipette and a pipetting device, the pipette comprises a bracket, a pipetting component and a head withdrawal component, the bracket comprises a supporting vertical plate and a supporting transverse plate which are connected; the liquid transferring component is arranged on the supporting vertical plate and is used for being detachably connected with the suction head, and the liquid transferring component is also used for driving the suction head to absorb or spit liquid; the head withdrawing assembly is arranged on the supporting transverse plate and used for pushing the suction head to separate from the pipetting assembly. According to the pipette provided by the embodiment of the utility model, the pipette assembly is connected with the supporting vertical plate, the head withdrawing assembly is connected with the supporting transverse plate, the support is stable, the pipette assembly is detachably connected with the suction head and can drive the suction head to perform liquid suction and liquid discharge operations, and the head withdrawing assembly can push the suction head to separate from the pipette assembly, so that the automatic installation and the disassembly of the suction head and the automatic operation of liquid suction and liquid discharge are realized, various operations are realized, the automation level is improved, and the efficiency of the pipetting operation is improved.

Description

Pipettor and pipetting device

Technical Field

The utility model relates to the technical field of pipetting, in particular to a pipettor and pipetting equipment.

Background

In the biological and chemical fields, it is often necessary to extract a sample liquid for performing related experiments, and a pipetting device is a device commonly used in operations for extracting a sample.

The automation level of the current pipetting device is not high, and the pipette tips are often required to be manually installed and removed, and even the pipette tips are required to be manually pumped and discharged, so that the pipetting efficiency is limited.

Disclosure of Invention

The utility model aims to provide a liquid transfer device and liquid transfer equipment, which solve the problem that the automation level of the existing liquid transfer equipment is not high.

In order to achieve the purpose of the utility model, the utility model provides the following technical scheme:

in a first aspect, the present utility model provides a pipette comprising: the bracket comprises a supporting vertical plate and a supporting transverse plate which are connected; the liquid transferring component is arranged on the supporting vertical plate and is used for being detachably connected with the suction head, and the liquid transferring component is also used for driving the suction head to absorb or spit liquid; the head withdrawing assembly is arranged on the supporting transverse plate and is used for pushing the suction head to be separated from the pipetting assembly.

In one embodiment, the pipetting assembly comprises a first driver, a piston cylinder having a receiving chamber in which the piston is received, a piston connected to the first driver to drive the piston to move in the receiving chamber, and an adapter connected to one end of the piston cylinder for detachable connection with the pipette tip, the adapter having an air flow passage in communication with the receiving chamber and the pipette tip.

In one embodiment, the end of the piston cylinder facing away from the adapter has an opening which communicates with the receiving space, through which opening the piston protrudes into the receiving space.

In one embodiment, the pipetting assembly further comprises a piston cover plate, the piston cover plate covers the opening, a through hole is formed in the piston cover plate, and the piston penetrates through the through hole.

In one embodiment, the opening of the piston cylinder is a step hole, a first sealing ring is arranged in the step hole, the piston cover plate presses the first sealing ring tightly, and the first sealing ring is tightly attached to the outer peripheral surface of the piston.

In one embodiment, the pipetting assembly further comprises a guide rail and a slider, the guide rail is fixedly connected with the supporting vertical plate, the slider is slidably connected with the guide rail, the slider is further connected with the first driving piece and the piston, the first driving piece drives the slider to move on the guide rail, and the slider drives the piston to move in the accommodating cavity.

In one embodiment, the pipetting assembly further comprises a transfer block, wherein the transfer block is connected between the sliding block and the piston, and the piston is made of ceramic.

In one embodiment, the first driving member is a linear motor, and an output shaft of the first driving member is connected to the piston; the output shaft of the first driving piece, the piston and the adapting piece all extend along a straight line and are positioned on the same extension straight line.

In one embodiment, the support risers are connected to the support cross-plates and are in the form of cross-sections; the piston cylinder is connected with the supporting vertical plate, a first through hole is formed in the supporting transverse plate, the piston cylinder is provided with a matching hole communicated with the first through hole and the accommodating cavity, a first matching part is arranged at one end of the adapting piece, and the first matching part penetrates through the first through hole and is detachably matched and connected with the matching hole.

In one embodiment, a second sealing ring is arranged between the first matching part and the matching hole.

In one embodiment, a second mating portion is provided at an end of the adapter remote from the piston cylinder, the second mating portion being adapted for detachable connection with the suction head.

In one embodiment, the second mating portion includes two annular protrusions spaced apart in an axial direction of the adapter, and outer diameters of the two annular protrusions are both larger than an inner diameter of the suction head.

In one embodiment, the pipetting assembly further comprises a first sensing member and a first control member, the first sensing member is electrically connected with the first control member, the first sensing member is used for sensing the position of the piston and outputting a first electric signal, and the first control member controls whether the first driving member drives the piston to move according to the first electric signal.

In one embodiment, the head withdrawing assembly comprises a second driving piece, a guide pillar and a push rod, wherein the guide pillar is in sliding connection with the supporting transverse plate, one end of the guide pillar is connected with the push rod, and the other end of the guide pillar can be abutted or separated from the second driving piece; the second driving piece is used for pushing the guide post to move, the guide post drives the push rod to move, and the push rod pushes the suction head to be separated from the pipetting component.

In one embodiment, when the pipette tip is not connected to the pipetting assembly, the length of the push rod extending out of the support cross plate exceeds the length of the pipetting assembly extending out of the support cross plate, and when the pipette tip is connected to the pipetting assembly, the push rod is contacted with and retracted from the pipette tip, and when the pipette tip is connected to the pipetting assembly, the push rod is contacted with and connected to the pipette tip.

In one embodiment, the supporting transverse plate is provided with a second through hole, and the guide post is arranged in the second through hole in a penetrating manner and can slide in the second through hole; a shaft shoulder is arranged at one end of the guide post, which is abutted against the second driving piece, the shaft shoulder is positioned outside the second through hole, and the size of the shaft shoulder is larger than the inner diameter of the second through hole; one end of the guide post, which is far away from the shaft shoulder, passes through the second through hole and is connected with the push rod.

In one embodiment, the head withdrawing assembly further comprises an elastic piece, wherein the elastic piece is located in the second through hole and sleeved on the periphery of the guide post, and two opposite ends of the elastic piece are respectively used for abutting against the top walls of the push rod and the second through hole; the elastic piece is in a compression state all the time and is switched between a first compression state and a second compression state, when the elastic piece is in the first compression state, the suction head is not connected with the pipetting module, and when the elastic piece is in the second compression state, the suction head is connected with the pipetting module.

In one embodiment, the head retracting assembly further comprises a supporting block, the supporting block is fixedly connected with the supporting transverse plate, and the second driving piece is fixed on the supporting block; the support block is provided with an accommodating space, a third through hole and a fourth through hole which are communicated with the accommodating space, and an output shaft of the second driving piece can sequentially pass through the third through hole and the fourth through hole to be abutted with the guide post; the fourth through hole is a step hole, one end of the guide pillar, which is far away from the shaft shoulder, sequentially penetrates through the fourth through hole and the second through hole to be connected with the push rod, and the shaft shoulder is used for being abutted to the step surface of the fourth through hole.

In one embodiment, the push rod comprises a cross rod and a vertical rod, one end of the cross rod is fixedly connected with one end of the guide post far away from the second driving piece, one end of the vertical rod is connected with one end of the cross rod far away from the guide post, and the extending direction of the vertical rod is the same as the extending direction of the adapter of the pipetting assembly; the vertical rod is provided with a sliding hole, the adapting piece is arranged in the sliding hole in a penetrating mode and can slide in the sliding hole, and the vertical rod moves to push the suction head to be separated from the adapting piece.

In one embodiment, the head withdrawing assembly further comprises a second sensing piece, a sensing pin and a second control piece, the second sensing piece is arranged in the accommodating space, the sensing pin is arranged on the shaft shoulder, the second sensing piece is electrically connected with the second control piece, the push rod is in contact with the suction head and pushes the guide post to move, the second sensing piece is used for sensing the position of the sensing pin and outputting a second electric signal, and the second control piece determines whether the suction head is connected to the liquid transferring assembly in place or not and/or whether the suction head is loosened or not according to the second electric signal.

In a second aspect, the present utility model further provides a pipetting device, including a mechanical arm, a pipette according to any of the various embodiments of the first aspect, and a suction head, where the mechanical arm is connected to the pipette, and the mechanical arm drives the pipette to move, so that a pipetting component of the pipette is connected to the suction head; and/or the mechanical arm drives the liquid dispenser to move from an initial position to a target position, so that the suction head performs liquid suction operation at the initial position and performs liquid discharge operation at the target position; and/or the mechanical arm drives the liquid dispenser to move to a recovery position so that the head withdrawing assembly of the liquid dispenser breaks away the suction head from the liquid dispensing assembly.

According to the liquid dispenser provided by the utility model, the liquid dispenser is connected with the supporting vertical plate through the liquid dispenser assembly, the head withdrawing assembly is connected with the supporting transverse plate, the support is stable, the liquid dispenser assembly is detachably connected with the suction head and can drive the suction head to perform liquid suction and liquid discharge operations, and the head withdrawing assembly can push the suction head to separate from the liquid dispenser assembly, so that the automatic mounting and dismounting of the suction head and the automatic operation of liquid suction and liquid discharge are realized, various operations are realized, the automation level is improved, and the efficiency of liquid discharge operation is improved.

Drawings

In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the utility model, and that other drawings can be obtained from them without inventive effort for a person skilled in the art.

FIG. 1 is a perspective view of a pipette of one embodiment;

FIG. 2 is a cross-sectional view of a pipette of one embodiment;

FIG. 3 is a perspective view of an embodiment of a pipette with a housing removed;

FIG. 4 is a perspective view of a pushrod of an embodiment;

FIG. 5 is a perspective view of an adapter of one embodiment;

figure 6 is a cross-sectional view of an embodiment of the adapter and suction head connection.

Reference numerals illustrate:

10-brackets, 11-supporting risers, 12-supporting transverse plates, 121-first through holes, 122-second through holes, 123-accommodating grooves, 13-shells and 14-fixing plates;

20-pipetting assembly, 21-first drive, 211-first output shaft, 22-piston cylinder, 221-receiving chamber, 222-opening, 223-mating hole, 23-piston, 24-adapter, 241-first mating part, 242-second mating part, 2421-adapter rod, 2422-first annular projection, 2423-second annular projection, 243-air flow channel, 244-annular clamping groove, 245-operating part, 246-operating plane, 247-positioning ring, 25-piston cover plate, 251-through hole, 26-first sealing ring, 271-guide rail, 272-slide, 28-adapter block, 29-second sealing ring;

30-head withdrawing components, 31-second driving parts, 311-second output shafts, 32-guide posts, 321-shaft shoulders, 33-push rods, 331-cross bars, 332-vertical rods, 333-matching bosses, 334-mounting holes, 335-sliding holes, 34-elastic parts, 35-supporting blocks, 351-accommodating spaces, 352-third through holes and 353-fourth through holes;

41-sensing piece, 42-first sensing piece, 43-second sensing piece, 431-mounting block, 44-sensing pin, 45-circuit board;

50-suction head, 501-liquid storage cavity, 51-adapting section, 52-main body section, 521-first liquid storage section, 522-transition section, 523-second liquid storage section, 53-liquid absorbing section;

60-quick-change joint.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present utility model without making any inventive effort, are intended to fall within the scope of the present utility model.

It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When a component is considered to be "connected" to another component, it can be directly connected to the other component or intervening components may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs. The terminology used in the description of the utility model herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Some embodiments of the present utility model are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.

Referring to fig. 1 to 3, an embodiment of the present utility model provides a pipetting device including a mechanical arm (not shown) and a pipette according to any embodiment of the present utility model.

The mechanical arm is connected with the liquid dispenser, and drives the liquid dispenser to move so as to connect the liquid dispenser pipetting assembly 20 with the pipette head 50; and/or the mechanical arm drives the liquid dispenser to move from the initial position to the target position, so that the suction head 50 performs liquid suction operation at the initial position and liquid discharge operation at the target position; and/or the mechanical arm drives the pipettor to move to the recovery position so that the head withdrawing assembly 30 of the pipettor disengages the suction head 50 from the pipetting assembly 20.

The mechanical arm may be a multi-axis mechanical arm, such as a four-axis mechanical arm, a six-axis mechanical arm, or an XYZ three-axis moving mechanism, which is not limited herein. The mechanical arm and the pipettor can be fixedly connected, such as by screwing, cementing, welding and the like; the mechanical arm and the pipettor can be detachably connected, such as magnetic connection, pneumatic connection and the like.

The pipetting device provided by the embodiment of the utility model can perform various operations by adopting the special pipetting device so as to improve the automation level and the pipetting efficiency.

The following describes the pipette according to the embodiment of the present utility model in detail.

Referring to fig. 1 to 3, an embodiment of the present utility model provides a pipette, which includes a rack 10, a pipetting assembly 20 and a retracting assembly 30. The support 10 serves as a structural support base, and the pipetting assembly 20 and the head withdrawal assembly 30 are both mounted on the support 10. The pipetting assembly 20 is used for connecting with the suction head 50 and controlling the suction head 50 to perform pipetting and spitting operations, and the withdrawal assembly 30 is used for separating the suction head 50 from the pipetting assembly 20 to perform withdrawal operations.

Specifically, the bracket 10 includes a support riser 11 and a support cross plate 12 connected; the support risers 11 may be provided as flat plates extending in the vertical direction, and the support cross plates 12 may be provided as flat plates extending in the horizontal direction. Of course, according to different setting requirements, the supporting vertical plate 11 may have a certain inclination angle with respect to the vertical direction, and the supporting horizontal plate 12 may also have a certain inclination angle with respect to the horizontal direction. The supporting risers 11 and the supporting cross plates 12 may be provided as flat plates and the flat plates are provided with grooves, through holes, protrusions and the like so as to facilitate the operations of installation, connection, cooperation and the like with other structures. The supporting risers 11 and the supporting cross plates 12 are connected and cross-shaped, for example, can be connected to form an L shape, a T shape, a ten shape and the like, and the connection of the two can be in a screw connection, a welding connection, a clamping connection and the like without limitation. The materials of the two are materials with higher strength, such as metal and alloy thereof, high-strength plastic and the like, without limitation.

The number of the supporting risers 11 may be plural or may be one, and is not limited. The pipette may further include a housing 13, where the housing 13 is connected to the supporting riser 11 and the supporting diaphragm 12, and the housing 13 can enclose and shield at least part of the pipetting component 20, the head withdrawal component 30, etc. together with the supporting riser 11 and the supporting diaphragm 12, so as to reduce exposed parts as far as possible, and on one hand, make the pipette have a complete and uniform appearance, and on the other hand, play roles in dust prevention, water prevention, etc.

The pipetting assembly 20 may be integrally provided on the support riser 11 or may be mostly provided on the support riser 11 and the rest on the support cross plate 12. The pipetting assembly 20 is configured to be detachably connected to the pipette tip 50, and the pipetting assembly 20 is further configured to drive the pipette tip 50 to aspirate or spit. The mechanical arm can drive the bracket 10 and the pipetting component 20 and the receding component 30 on the bracket to integrally move, wherein the pipetting component 20 can be connected with the suction head 50 after moving. The specific structure of the pipetting assembly 20 is not limited and can provide positive or negative pressure. By applying negative pressure to the suction head 50, the suction head 50 can be made to suck the sample liquid, the liquid sucking operation is realized, and by applying positive pressure to the suction head 50, the sample liquid in the suction head 50 can be pushed out, and the liquid discharging operation is realized.

The head withdrawal assembly 30 is disposed on the support cross plate 12, and the head withdrawal assembly 30 is used to push the pipette tips 50 off of the pipetting assembly 20. The specific structure of the head retracting assembly 30 is not limited, and the head retracting assembly 30 may be moved to disengage the suction head 50 from the pipetting assembly 20, thereby achieving a head retracting operation.

The bracket 10 is further provided with a quick-change connector 60, and the quick-change connector 60 may be disposed on the supporting transverse plate 12, for example, for detachable connection with a mechanical arm, and the specific structure of the quick-change connector 60 is not limited, and the detachable connection manner includes, but is not limited to, pneumatic connection, magnetic connection, and the like. Through quick change connector 60, can realize carrying out quick connect and disconnection with the quick change connector on the arm, automated integration is high, also is convenient for the arm to be able to quick change the end effector of different specifications or different functions and carries out corresponding operation.

The application method of the pipette provided by the embodiment of the utility model comprises the following steps: the mechanical arm drives the liquid dispenser to integrally move to the placement position of the suction head 50, so that the liquid dispenser assembly 20 is connected with the suction head 50 at the placement position of the suction head 50 (the mechanical arm drives the liquid dispenser assembly 20 to downwards prick the suction head 50 with a certain force, so that the liquid dispenser assembly 20 is in interference connection with the suction head 50), then the liquid dispenser and the suction head 50 are driven to move to the initial position, the liquid dispenser assembly 20 drives the suction head 50 to absorb liquid, and then the mechanical arm drives the liquid dispenser and the suction head 50 to move from the initial position to the target position again, and the liquid dispenser assembly 20 drives the suction head 50 to discharge liquid at the target position. Thus, the steps of mounting the pipette tip 50 and pipetting and spitting are completed once, and one pipette tip 50 can perform pipetting and spitting operations a plurality of times until the desired pipetting capacity of one sample liquid is completed. Then, when another sample liquid needs to be pipetted, the suction head 50 needs to be replaced, and at the moment, the mechanical arm drives the pipettor and the suction head 50 to move to the recovery position, and the head withdrawing assembly 30 moves to push out the suction head 50 connected with the pipetting assembly 20, so that head withdrawing operation is realized. The above-described operations of mounting the pipetting assembly 20 to the pipette tip 50, pipetting and pipetting are repeated.

According to the pipette provided by the embodiment of the utility model, the pipette assembly 20 is arranged to be connected with the supporting vertical plate 11, the head withdrawing assembly 30 is connected with the supporting transverse plate 12, the support is stable, the pipette assembly 20 is detachably connected with the suction head 50 and can drive the suction head 50 to perform liquid suction and liquid discharge operations, and the head withdrawing assembly 30 can push the suction head 50 to be separated from the pipette assembly 20, so that the automatic installation and detachment of the suction head 50 and the automatic operation of liquid suction and liquid discharge are realized, various operations are realized, the automation level is improved, and the efficiency of liquid discharge operation is improved.

Referring to fig. 2 and 6, the pipetting assembly 20 comprises a first drive member 21, a piston cylinder 22, a piston 23 and an adapter member 24. The piston cylinder 22 has a receiving chamber 221, and the piston 23 is received in the receiving chamber 221, and the first driving member 21 is connected to the piston 23 to drive the piston 23 to move in the receiving chamber 221. An adapter 24 is connected to one end of the piston cylinder 22, the adapter 24 being adapted for detachable connection with the suction head 50, the adapter 24 having an air flow channel 243 communicating with the receiving chamber 221, the suction head 50.

Referring to fig. 2, the first driving member 21, the piston 23, the piston cylinder 22 and the adapter 24 are sequentially arranged along a straight line, which is substantially parallel to the supporting riser 11. The first driving member 21 and the piston cylinder 22 are respectively connected and fixed with the supporting vertical plate 11 in a threaded manner. Of course, the first driving member 21 and the piston cylinder 22 may be connected to the supporting riser 11 by other connecting and fixing methods, which are not limited herein. For example, the first driving member 21 is connected to the fixing plate 14, and the fixing plate 14 is screwed to the supporting riser 11.

The first drive member 21 has a first output shaft 211, which first output shaft 211 is movable relative to a main body portion of the first drive member 21, which is fixedly connected to the support riser 11. The movement of the first output shaft 211 relative to the main body portion of the first driving member 21 may be a rotational movement, a linear movement, or a mixed movement of a linear movement and a rotational movement. For example, the first output shaft 211 may be rotationally coupled to the piston 23 via a transmission mechanism, so that the rotational motion of the first output shaft 211 is converted into a linear motion of the piston 23, and the direction of the linear motion of the piston 23 may be substantially the same as the extending direction of the support riser 11, i.e., may be substantially the vertical direction. For another example, the first output shaft 211 may perform a linear motion in a direction substantially the same as the extending direction of the supporting riser 11, that is, in a substantially vertical direction, the first output shaft 211 stretches relative to the main body portion of the first driving member 21, and one end of the first output shaft 211 that stretches out may be connected or indirectly connected to the piston 23, and the linear motion of the first output shaft 211 directly drives the piston 23 to perform a linear motion in the same direction.

Alternatively, the first driving member 21 is a linear motor, and the output shaft of the first driving member 21 is connected to the piston 23, that is, the first output shaft 211 may be directly or indirectly connected to the piston 23; the output shaft of the first drive member 21, the piston 23 and the adapter member 24 all extend along a straight line and lie on the same extension line. So set up, first driving piece 21 is linear electric motor, can direct drive first output shaft 211 makes rectilinear motion, and each structure is arranged on same extension straight line, and foretell linear arrangement, simple structure, the drive is also direct, can promote reliability and control accuracy.

The outer wall of the piston cylinder 22 is in threaded connection with the supporting vertical plate 11, and other connecting and fixing modes can be adopted. The receiving chamber 221 of the piston cylinder 22 extends along a straight line which is also substantially the same as the direction of extension of the support riser 11, i.e. substantially in a vertical direction. The piston 23 is accommodated in the accommodation chamber 221, and an outer circumferential surface of the piston 23 is in close contact with an inner circumferential wall of the accommodation chamber 221. By the movement of the piston 23 in the piston cylinder 22, the distance between the end surface of the piston 23 at the end remote from the first driving member 21 and the bottom wall of the accommodation chamber 221 facing the first driving member 21 is changed, so that the volume of the cavity of the accommodation chamber 221 is changed continuously, and positive pressure or negative pressure is generated.

Referring to fig. 2 and 6, the adapter 24 is connected to an end of the piston cylinder 22 remote from the first driver 21, and the air flow channel 243 of the adapter 24 communicates with the accommodation chamber 221 of the piston cylinder 22, i.e., the air flow channel 243 communicates with the accommodation chamber 221 at a bottom wall of the accommodation chamber 221 facing the first driver 21. By moving the piston 23 in the receiving chamber 221, positive and negative pressures can be generated which can be transferred to the suction head 50 connected to the adapter 24 via the air flow channel 243 communicating with the receiving chamber 221, thereby controlling the suction head 50 to perform a liquid sucking or discharging operation.

The structure provided with the first driving piece 21, the piston cylinder 22, the piston 23 and the adapting piece 24 is simple and reliable in structure, positive pressure or negative pressure can be provided for the suction head 50 through the movement of the piston 23 relative to the piston cylinder 22 so as to perform liquid suction or liquid discharge operation, and the operation is simple.

Alternatively, referring to fig. 2, 5 and 6, the support cross plate 12 is provided with a first through hole 121, and one end of the piston cylinder 22 remote from the first driving member 21 is provided with a fitting hole 223, and the fitting hole 223 communicates with the first through hole 121 and the accommodation chamber 221. One end of the adapter 24 is provided with a first fitting portion 241, and the first fitting portion 241 is detachably fitted and connected with the fitting hole 223 through the first through hole 121.

The diameter of the first through hole 121 may be slightly larger than the diameter of the fitting hole 223 so that the first fitting portion 241 of the adapter 24 may pass through the first through hole 121. The diameter of the first through hole 121 may be smaller than the outer diameter of the piston cylinder 22, and an end surface of the piston cylinder 22 at an end remote from the first driving member 21 may be in contact with the support cross plate 12, so that the support cross plate 12 may function to support the piston cylinder 22. The first through hole 121 and the fitting hole 223 may be coaxially disposed. The mating hole 223 can be a screw hole, the first mating portion 241 can be a screw rod, the first mating portion 241 and the mating hole 223 can be in threaded fit, and the threaded fit has the advantages of convenience in installation and disassembly, stability in connection and the like.

Referring to fig. 2 and 5, the adapter 24 includes a first mating portion 241 at one end and a second mating portion 242 at the opposite end. The operation portion 245 may further include a first engaging portion 241 and a second engaging portion 242 connected to opposite ends of the operation portion 245, respectively, and the first engaging portion 241, the operation portion 245 and the second engaging portion 242 may be coaxially disposed and may be substantially cylindrical. The adapter 24 is connected to the piston cylinder 22 at a first end thereof with a first mating portion 241, and is connected to the piston cylinder 22 at a second end thereof with a second mating portion 242, the second mating portion 242 being adapted to be detachably connected to the suction head 50. The outer circumferential surface of the operation portion 245 may be formed with operation planes 246, and the operation planes 246 may be 2 and disposed at opposite sides of the operation portion 245 and parallel to each other, and the operation planes 246 are used to be engaged with the operation tool to connect and fix the first engagement portion 241 with the engagement hole 223. The operating tool is, for example, a wrench.

An annular clamping groove 244 is formed at one end of the screw rod of the first matching portion 241 connected with the operation portion 245, and the annular clamping groove 244 is used for accommodating the second sealing ring 29. After the first fitting portion 241 is fitted into the fitting hole 223, the second seal ring 29 is located between the first fitting portion 241 and the fitting hole 223. The second seal ring 29 may be a "y" shaped seal ring for sealing a gap between the first fitting portion 241 and the fitting hole 223.

Optionally, a positioning ring 247 is disposed on the outer periphery of the end portion of the first matching portion 241 connected to the operation portion 245, the positioning ring 247 surrounds the first matching portion 241, and the diameter of the positioning ring 247 is larger than the diameter of the first matching portion 241 and smaller than or equal to the diameter of the operation portion 245. The fitting hole 223 may be configured as a stepped hole, the diameter of the outer side is larger than the diameter of the inner side, when the first fitting portion 241 is installed with the fitting hole 223, the first fitting portion 241 extends into the inner side of the fitting hole 223, the positioning ring 247 extends into the outer side of the fitting hole 223, and the positioning ring 247 may contact with the sidewall of the outer side of the fitting hole 223. A portion of the end surface of the operation portion 245 where the first engagement portion 241 is provided, which is located outside the positioning ring 247, may abut against the lower end surface of the piston cylinder 22. The positioning ring 247 is disposed below the annular clamping groove 244, and can also form a side wall of the annular clamping groove 244 to limit the second sealing ring 29.

Referring to fig. 5 and 6, the second fitting portion 242 includes two annular projections disposed at intervals in the axial direction of the adapter 24, both of which have an outer diameter larger than the inner diameter of the suction head 50.

Specifically, the second fitting portion 242 includes an adapter rod 2421, a first annular protrusion 2422 and a second annular protrusion 2423, one end of the adapter rod 2421 is connected with one end of the operating portion 245 away from the first fitting portion 241, and the first annular protrusion 2422 and the second annular protrusion 2423 are disposed around the adapter rod 2421. In a longitudinal section, the first annular protrusion 2422 and the second annular protrusion 2423 each have a circular arc shape. The first annular protrusion 2422 is located between the second annular protrusion 2423 and the operation part 245, the first annular protrusion 2422 may be connected with the operation part 245, and the second annular protrusion 2423 may be disposed at an end of the adapter rod 2421 remote from the operation part 245.

The suction head 50 comprises an adapter section 51, a main body section 52 and a suction section 53, which are connected in sequence, the adapter section 51 being provided with a certain elastic deformability, the adapter section 51 being intended to be connected to the second mating part 242. When the second fitting portion 242 is connected with the fitting section 51, the second annular protrusion 2423 is inserted into the fitting section 51, and the fitting section 51 is pressed to deform, so that the fitting section 51 is tightly contacted with the second annular protrusion 2423, and then the second fitting section is continuously inserted, so that the first annular protrusion 2422 is tightly contacted with the fitting section 51, the second fitting portion 242 and the fitting section 51 are tightly connected and fixed by friction, and the first annular protrusion 2422 and the second annular protrusion 2423 are matched to realize the coaxial positioning of the fitting 24 and the suction head 50, so that the connection is stable, the shaking is not easy, and the double sealing function is realized. When the tip 50 needs to be replaced, the tip 50 is forcibly pushed out from the second engagement portion 242 to a side away from the operation portion 245 until the tip 50 is separated.

The end of the wicking segment 53 remote from the body segment 52 is pointed for wicking and spitting. The suction head 50 has a reservoir 501, which reservoir 501 is used for storing liquid. The inside of the adapter 24 is provided with an air flow channel 243 penetrating through two ends in the axial direction, after the second matching part 242 is connected with the adapter section 51, the air flow channel 243 in the adapter 24 is communicated with the liquid storage cavity 501, the air flow channel 243 is also communicated with the accommodating cavity 221 of the piston cylinder 22, positive pressure or negative pressure produced by the movement of the piston 23 can be transferred to the liquid storage cavity 501 through the air flow channel 243 of the adapter 24, liquid can be absorbed through the liquid absorption section 53 when the liquid storage cavity 501 is in negative pressure, and the sample liquid stored in the liquid storage cavity 501 can be driven to be ejected from the suction head 50 when the liquid storage cavity 501 is in positive pressure.

Optionally, the main body section 52 includes a first liquid storage section 521, a transition section 522, and a second liquid storage section 523 sequentially connected, where an end of the first liquid storage section 521 away from the transition section 522 is connected to the adapting section 51, and an end of the second liquid storage section 523 away from the transition section 522 is connected to the liquid absorbing section 53. From the adaptation section 51 to the direction of imbibition section 53, first stock solution section 521, changeover portion 522 and second stock solution section 523 are the throat structure, and first stock solution section 521 and second stock solution section 523 all are connected with changeover portion 522 slick and sly transition. Further, the minimum inner diameter of the first liquid storage section 521 is larger than the maximum inner diameter of the second liquid storage section 523, and the transition section 522 is tangential to both the first liquid storage section 521 and the second liquid storage section 523. The main body section 52 is provided with a necking structure, so that the sample liquid can be smoothly sucked and discharged out of the suction head 50, the residues of the sample liquid are not easy to generate in each section in the main body section 52, and the size of the first liquid storage section 521 is larger than that of the second liquid storage section 523, so that the suction head can suck the sample liquid with larger capacity, and the liquid transferring efficiency can be improved.

In one embodiment, referring to fig. 2, an end of the piston cylinder 22 facing away from the adapter 24, i.e. the end facing the first driving member 21, has an opening 222 communicating with the accommodating chamber 221, and the piston 23 extends into the accommodating chamber 221 through the opening 222. The piston 23 may have a cylindrical shape, and the shape of the opening 222 may be adapted to the shape of the receiving chamber 221, for example, a circular shape; the diameter of the opening 222 may be equal to the inner diameter of the receiving chamber 221 or greater than the inner diameter of the receiving chamber 221 such that the piston 23 may extend into the receiving chamber 221 through the opening 222. Alternatively, the outer circumferential surface of the piston 23 is in close contact with the inner circumferential wall of the accommodation chamber 221, so that air of the portion of the accommodation chamber 221 communicating with the air flow passage 243 of the adapter 24 does not leak from the surface of the piston 23 in contact with the accommodation chamber 221 to the opening 222 side, and the control accuracy of the positive pressure and the negative pressure can be improved. The piston 23 is at least partially exposed from the opening 222 for connection with the first output shaft 211 of the first driver 21. By providing this opening 222, the installation of the piston 23 can be facilitated.

Optionally, the pipetting assembly 20 further includes a piston cover 25, where the piston cover 25 covers the opening 222, the piston cover 25 is provided with a through hole 251, and the piston 23 is disposed through the through hole 251. The through hole 251 has a shape and a size corresponding to those of the piston 23, and when the piston 23 is cylindrical, the through hole 251 is also a circular hole, and the diameter of the piston 23 is equal to that of the through hole 251. By doing so, the outer peripheral surface of the piston 23 is also brought into close contact with the inner wall of the passage hole 251, so that air is not leaked from the surface where the piston 23 is in contact with the piston cover 25, improving the control accuracy of positive and negative pressures. Meanwhile, the cover plate is arranged at the opening 222, so that the containing cavity 221 of the piston cylinder 22 can be protected from dust, water and the like.

Optionally, the opening 222 of the piston cylinder 22 is a stepped hole, a first sealing ring 26 is arranged in the stepped hole, the piston cover plate 25 presses the first sealing ring 26 tightly, and the first sealing ring 26 is tightly attached to the outer peripheral surface of the piston 23. The shape of the first seal ring 26 may be substantially circular, the shape of the longitudinal section of the first seal ring 26 corresponds to the shape of the stepped hole, the shape of the longitudinal section may be "L", "T", etc., the outer side surface of the first seal ring 26 is in close contact with the side wall of the stepped hole, and the inner side surface of the first seal ring 26 is in close contact with the outer peripheral surface of the piston 23, so as to perform a sealing function. In the present embodiment, there may be a gap between the outer circumferential surface of the piston 23 and the inner wall of the accommodation chamber 221, and the inner wall of the passage hole 251, and since the first seal ring 26 is provided to seal, the gas in the accommodation chamber 221 does not leak from the gap between the outer circumferential surface of the piston and the inner wall of the accommodation chamber 221, thereby achieving sealing.

Optionally, the pipetting assembly 20 further comprises a guide 271 and a slider 272. The guide rail 271 is fixedly connected to the support riser 11, and the connection and fixation may be by screw connection, clip connection, or the like, without limitation. The shape of the guide rail 271 is not limited, and the guide rail 271 may be formed with a guide structure by grooving, providing a protrusion, or the like. The slider 272 is slidably connected to the rail 271, and the slider 272 may be provided with a structure that cooperates with a guide structure on the rail 271 such that the slider 272 can slide in a prescribed direction relative to the rail 271. For example, the slider 272 may slide in a direction substantially parallel to the supporting riser 11 with respect to the guide rail 271, i.e., may slide substantially in a vertical direction, the guide rail 271 serving as a guide. The slider 272 is fixed in other directions, i.e., the rail 271 also plays a limiting role on the slider 272, in addition to being slidable in the extending direction of the guide structure of the rail 271.

The slider 272 is connected to the first driving member 21 and the piston 23, the first driving member 21 drives the slider 272 to move on the guide rail 271, and the slider 272 drives the piston 23 to move in the accommodating chamber 221. In the embodiment in which the first driving member 21 is a linear motor, one end of the slider 272 is connected to the first output shaft 211 of the first driving member 21, the opposite end is connected to the end of the piston 23 remote from the adapter 24, and the linear movement direction of the first output shaft 211 is the same as the sliding direction of the slider 272 on the guide rail 271 and the direction in which the piston 23 moves in the piston cylinder 22. By providing the guide rail 271 and the slider 272, the reliability of the driving structure is improved, so that the piston 23 can be moved in a determined direction, and the structure is reliable and stable.

Optionally, the pipetting assembly 20 further comprises a adapter 28, the adapter 28 being connected between the slide 272 and the piston 23. The adapter block 28 can be of a special-shaped structure, so that the structure of the piston 23 is regular and simple, and the piston 23 can be conveniently machined. In addition, compared with the piston 23 directly connected with the sliding block 272, the piston 23 is additionally provided with the adapter block 28, so that concentricity errors when the piston 23 is matched with the piston cylinder 22 can be effectively eliminated, the piston 23 can be prevented from being designed into a different structure suitable for being directly connected with the sliding block 272, and the processing difficulty is reduced.

Optionally, the piston 23 is made of ceramic, and compared with other materials, the ceramic material has good corrosion resistance, good wear resistance, long service life and good dimensional temperature stability, can meet long-term use requirements, and basically does not need replacement. In addition, the foregoing adapter block 28 does not need to generate friction with the piston cylinder 22, and has no requirement on wear resistance, so the adapter block 28 can be made of a material easy to process, and the ceramic material has a relatively high processing difficulty, so the processing difficulty can be reduced in response to the arrangement of the adapter block 28 to connect the slider 272 and the piston 23 in the foregoing embodiment.

In other embodiments, the piston 23 may be made of high-strength plastic, such as polyether ether ketone or corrosion-resistant plastic material for a syringe.

Referring to fig. 2 and 3, the pipetting assembly 20 further includes a first sensing element 42 and a first control element (not shown), the first sensing element 42 is electrically connected to the first control element, the first sensing element 42 is configured to sense a position of the piston 23 and output a first electrical signal, and the first control element controls whether the first driving element 21 drives the piston 23 to move according to the first electrical signal.

According to the pipetting operation flow described above, both the pipetting and the pipetting operations are performed by moving the piston 23 in the piston cylinder 22 and transmitting positive or negative pressure to the liquid storage chamber 501, and therefore, the timing of pipetting and pipetting, the pipetting capacity, and the like can be determined by controlling the displacement of the piston 23 with respect to the piston cylinder 22. The first sensing member 42 is provided to sense the position of the piston 23, and is capable of detecting the current state of liquid suction or liquid discharge, determining whether the desired state is reached, and determining whether to drive the piston 23 to move.

The application method comprises the following steps: during the pipetting operation, the stroke of the first output shaft 211 is determined, that is, when the first output shaft 211 does not aspirate liquid, the first output shaft 211 extends out for the longest distance relative to the main body part of the first driving member 21, then the first output shaft 211 retracts to drive the sliding block 272, the adapter 28 and the piston 23 to move towards the first driving member 21 side, so as to form negative pressure, the pipette tip 50 starts aspirating until the first driving member 21 retracts to a designated position, and the pipetting operation is completed, and at the moment, the pipette tip 50 just aspirates a sample liquid with a designated volume. In the liquid discharge operation, all of the liquid may be discharged at a time, or a liquid separation operation may be performed, so that the sample liquid in the suction head 50 may be placed in different vessels by a plurality of liquid discharge operations. Regardless of the liquid discharge, the first output shaft 211 of the first driving member 21 extends to push the sliding block 272, the adapter 28 and the piston 23 to move to a side far away from the first driving member 21, the liquid storage cavity 501 generates positive pressure, the sample liquid is discharged from the suction head 50, in the process, the position of the piston 23 can be sensed by the first sensing member 42, and further, whether the required liquid discharge amount is reached or not is determined, if the required liquid discharge amount is reached, the first control member controls the first driving member 21 to stop, and the first output shaft 211 does not move any more. If the sample liquid needs to be completely discharged at a time, the first sensing member 42 detects that the position of the piston 23 is in place, and after the sample liquid in the liquid storage cavity 501 is completely discharged, the first control member controls the first driving member 21 to stop, so that abrasion caused by the fact that the piston 23 continuously extends to collide with the bottom wall of the piston cylinder 22 can be avoided, pollution caused by residues is easy to generate, and overload of the first driving member 21 is easy to cause, so that the service life is reduced.

Alternatively, since the piston 23 is connected to the first output shaft 211 of the first driver 21 through the joint block 28 and the slider 272, the position of the piston 23 can also be determined by detecting the position of the joint block 28, the slider 272 or the first output shaft 211.

Alternatively, a sensing piece 41 may be provided on any one of the piston 23, the adapter block 28, the slider 272 and the first output shaft 211, a first sensing piece 42 may be provided on the support riser 11, and the position of the piston 23 may be determined by sensing the sensing piece 41 by the first sensing piece 42. For example, the position of the first sensing member 42 when sensing the sensing piece 41 may be set to be the initial position of the piston 23, and the piston 23 is returned to this position, i.e., the piston returns to zero, before or after liquid suction or discharge. At the time of pipetting, whether pipetting is completed may be defined by defining a movement stroke of the first output shaft 211; when the first sensing piece 42 senses the sensing piece 41 during liquid discharge, the liquid discharge is completed.

The first sensing piece 42 may be a sensor for detecting various positions, the sensing piece 41 may be a device for sensing the first sensing piece 42, for example, the first sensing piece 42 is a slot structure, two sides of the slot are respectively provided with a laser emitting end and a laser receiving end, the sensing piece 41 may be a metal baffle, and when the sensing piece 41 enters the slot, the laser receiving end cannot normally receive an optical signal and sends a corresponding signal to the first control piece. The first control element may be a chip, a PLC, a mobile terminal, an electronic computer, etc., which are not limited. In some embodiments, for example, the first sensing element 42 may not be provided with the sensing piece 41 when detecting the position by the optical principle.

By providing the first sensing member 42 and the first control member, automated control of liquid suction and liquid discharge can be achieved.

In other embodiments, the position of the piston 23 may be detected by other means, and is not limited to the embodiment of the first sensing piece 42 and the sensing piece 41.

In one embodiment, referring to fig. 1 to 3, the head retracting assembly 30 includes a second driving member 31, a guide post 32 and a push rod 33. The supporting transverse plate 12 is provided with a second through hole 122, and the guide post 32 is arranged through the second through hole 122, so that the guide post 32 is in sliding connection with the supporting transverse plate 12. One end of the guide post 32 is connected to the push rod 33, and the other end of the guide post 32 can be abutted against or separated from the second driving member 31. The second driving member 31 is configured to push the guide post 32 to move, the guide post 32 drives the push rod 33 to move, and the push rod 33 pushes the suction head 50 to disengage from the pipetting assembly 20.

The second driving member 31 includes a second output shaft 311, where the second output shaft 311 is configured to abut against the guide post 32 to push the guide post 32 to move. The second driving member 31 may be a linear motor, and may directly drive the second output shaft 311 to perform linear motion.

When the pipetting assembly 20 performs pipetting or spitting operations and the mechanical arm drives the pipettor and the suction head 50 to mount and drive the whole moving process, the second driving member 31 is in a stop state, and at this time, the second output shaft 311 and the guide post 32 are in a separated state, and the second output shaft 311 and the guide post 32 have a separation distance, so that the normal pipetting operations are prevented from being affected. When the pipette tip 50 needs to be replaced after pipetting, the second driving member 31 drives the second output shaft 311 to extend to abut against the guide post 32 and push the guide post 32 to slide in the second through hole 122, so that the guide post 32 drives the push rod 33 to move, and the push rod 33 pushes the pipette tip 50 to be separated from the pipetting assembly 20.

The second output shaft 311, the guide post 32 and the push rod 33 are sequentially arranged in a straight line direction, wherein the straight line is the axis of the second output shaft 311 and the guide post 32, and the second output shaft 311 and the first output shaft 211 can be arranged in parallel, that is, the pipetting component 20 and the head withdrawing component 30 can be arranged side by side, so that the structure is compact.

The structure of the push rod 33 is not limited, and one end thereof is connected to the guide post 32, and the other end thereof is used for pushing the suction head 50. Alternatively, referring to fig. 2 and 4, the push rod 33 includes a cross rod 331 and a vertical rod 332, the cross rod 331 is generally parallel to the supporting cross plate 12, one end of the cross rod 331 is fixedly connected to one end of the guide post 32 far away from the second driving member 31, the connection fixing manner may be a threaded connection, a clamping connection, etc., one end of the vertical rod 332 is connected to one end of the cross rod 331 far away from the guide post 32, and the extending direction of the vertical rod 332 is the same as the extending direction of the adapter 24.

The cross rod 331 is provided with a matching boss 333, the cross rod 331 is further provided with a mounting hole 334, the mounting hole 334 can penetrate through the cross rod 331 and the matching boss 333, the matching boss 333 is matched and connected with one end, far away from the second driving piece 31, of the guide post 32, and a fastener such as a screw can penetrate through the mounting hole 334 to be in threaded connection with the guide post 32. The mating boss 333 is shaped in a non-circular manner, for example, the mating boss 333 may include a circular ring-shaped collar and a protrusion connected to the outer periphery of the circular ring-shaped collar, so that the mating boss 333 can limit the relative rotation of the two in the circumferential direction of the guide post 32 after being mated with the guide post 32.

The vertical rod 332 is provided with a sliding hole 335, and the adapter 24 is inserted into the sliding hole 335 and can slide in the sliding hole 335. When the suction head 50 needs to be pushed out of the adapter 24, the guide post 32 pushes the cross rod 331 to move, the cross rod 331 drives the vertical rod 332 to move, and the end part of the vertical rod 332 away from the piston cylinder 22 pushes the suction head 50 to be separated from the adapter 24. The push rod 331 has a simple structure, can rapidly realize the action of pushing out the suction head 50, and has good reliability.

Alternatively, referring to FIGS. 2 and 4, when the pipette tip 50 is not coupled to the pipetting assembly 20, the push rod 33 extends beyond the length of the pipetting assembly 20 extending beyond the support cross plate 12. During connection of the pipette tip 50 to the pipetting assembly 20, the push rod 33 is first brought into contact with the pipette tip 50 and retracted, and after the pipetting assembly 20 is brought into contact with and connected to the pipette tip 50.

Because the adapter 24 is fixedly connected to the piston cylinder 22, the adapter 24 cannot move relative to the support cross plate 12. When the pipette tip 50 is not connected to the pipetting assembly 20, the end of the vertical rod 332 remote from the piston cylinder 22 extends beyond the adapter 24, i.e. the second mating part 242 of the adapter 24 is accommodated in the sliding hole 335 of the vertical rod 332. When the pipette is moved integrally to connect with the suction head 50, the end of the vertical rod 332 away from the piston cylinder 22 is firstly contacted with the suction head 50, and then the suction head 50 pushes the vertical rod 332 to retract and gradually enables the adapter 24 to be inserted into the suction head 50 as the pipette moves towards one side of the suction head 50. During the whole process from when the suction head 50 pushes the push rod 33 to retract to when the suction head 50 and the adapter 24 are installed, the second output shaft 311 of the second driving piece 31 always has a spacing distance from the guide post 32, namely, the push rod 33 can freely move, so that interference is not caused to the installation of the suction head 50 and the adapter 24.

By the arrangement, the push rod 33 can play a role in protecting the adapter 24, so that the adapter 24 is prevented from being damaged by collision, and meanwhile, the installation of the suction head 50 and the adapter 24 is not influenced.

Referring to fig. 2, a shoulder 321 is disposed at an end of the guide post 32 abutting against the second driving member 31, the shoulder 321 is located outside the second through hole 122, and the size of the shoulder 321 is larger than the inner diameter of the second through hole 122. One end of the guide post 32, which is far away from the shaft shoulder 321, passes through the second through hole 122 and is connected with the push rod 33.

The shaft shoulder 321 is provided, so that the guide post 32 and the push rod 33 connected with the guide post 32 cannot be separated from the supporting transverse plate 12 when the push rod 33 is not pushed by the suction head 50 when the suction head 50 is not installed in the pipetting assembly 20.

Referring to fig. 2, the head retracting assembly 30 further includes an elastic member 34, where the elastic member 34 is located in the second through hole 122 and sleeved on the outer periphery of the guide post 32, and opposite ends of the elastic member 34 are respectively used to abut against the push rod 33 and the top wall of the second through hole 122.

Specifically, the head retracting assembly 30 further includes a supporting block 35, the supporting block 35 is fixedly connected with the supporting transverse plate 12, and the second driving member 31 is fixed on the supporting block 35. The supporting block 35 at least partially shields the second through hole 122, so that the top wall of the second through hole 122 is the bottom surface of the supporting block 35, one end of the elastic piece 34 is abutted on the supporting block 35, and the other end of the elastic piece 34 is abutted with the cross rod 331 of the push rod 33. The elastic member 34 may be a spring.

The elastic member 34 is always in a compressed state, and is switched between a first compressed state and a second compressed state, when the elastic member 34 is in the first compressed state, the suction head 50 is not connected with the pipetting module 20, and when the elastic member 34 is in the second compressed state, the suction head 50 is connected with the pipetting module 20.

The supporting block 35 is provided with an accommodating space 351, a third through hole 352 and a fourth through hole 353 which are communicated with the accommodating space 351, and the output shaft of the second driving member 31 can sequentially pass through the third through hole 352 and the fourth through hole 353 to be in contact with the guide post 32.

The fourth through hole 353 is a step hole, and one end of the guide post 32 away from the shaft shoulder 321 sequentially passes through the fourth through hole 353 and the second through hole 122 to be connected with the push rod 33, and the shaft shoulder 321 can be abutted against the step surface of the fourth through hole 353.

By arranging the elastic piece 34 in a compressed state all the time, the shaft shoulder 321 of the guide post 32 is always positioned close to the supporting transverse plate 12, and the guide post cannot shake or jump at will, thereby avoiding abnormal sound generation and abnormal contact with the second output shaft 311, and avoiding abnormal pushing of the guide post 32 and the push rod 33 by the second output shaft 311 to separate the suction head 50 from the adapting piece 24.

Optionally, a receiving groove 123 may be formed on a side of the supporting transverse plate 12 facing away from the first driving member 21 and the second driving member 31, where the receiving groove 123 may receive the push rod 33, so that the push rod 33 may be received in the receiving groove 123 when retracted, and the overall volume of the pipette may be reduced, so that the structure is more compact.

Referring to fig. 1 to 3, the head retracting assembly 30 further includes a second sensing member 43, a sensing pin 44, and a second control member. The second sensing piece 43 is disposed in the accommodation space 351 and can be fixed to a wall surface of the accommodation space 351 by the mounting block 431. The sensing pin 44 is provided on the shoulder 321 and protrudes toward the side of the second driving member 31. The second sensing piece 43 is electrically connected with the second control piece, the push rod 33 is in contact with the suction head 50, and the push rod 33 pushes the guide post 32 to move, so that the sensing pin 44 on the guide post 32 is driven to move. The second sensing member 43 is configured to sense a position of the sensing pin 44 and output a second electrical signal, and the second control member determines whether the suction head 50 is connected to the pipetting assembly 20 and whether the suction head 50 is loose according to the second electrical signal, specifically, if the suction head 50 is loose, the spring rebounds to drive the guide post 32 and the push rod 33 to move downward, and the sensing pin 44 moves downward away from the second sensing member 43, so that the suction head 50 can be judged to have a loose condition, so that an experimenter can process in time.

The second sensing member 43 may be a similar device to the first sensing member 42, the sensing pin 44 may be a similar device to the sensing piece 41, and the second sensing member may be a similar device to the first sensing member, and reference may be made to the foregoing description of the first sensing member 42, the sensing piece 41 and the first sensing member, which will not be repeated herein. Alternatively, the second control member and the first control member may be integrated into one control member. Referring to fig. 3, the support block 35 may be provided with a circuit board 45, and the first and second control members may be provided on the circuit board 45. Optionally, the circuit board 45 may also be a patch panel for providing power and data transmission.

The application method comprises the following steps: when the mechanical arm drives the pipette to move integrally and performs the operation of connecting the pipette assembly 20 with the pipette head 50, the pipette head 50 pushes the push rod 33 to move towards one side of the second driving member 31, the guide post 32 and the sensing pin 44 thereon move along with each other, and the sensing pin 44 moves from bottom to top in fig. 2 until the second sensing member 43 can sense the position of the sensing pin 44 and output a second electrical signal, so that it can be determined that the pipette head 50 is connected with the pipette assembly 20. By providing the sensing pin 44 and the second sensing member 43, control of the mounting of the pipette tip 50 to the pipetting assembly 20 is achieved.

When it is desired to disengage the pipette tip 50 from the pipetting assembly 20, the second drive member 31 drives the guide post 32 downward so that the push rod 33 pushes the pipette tip 50 out of the way, and when the second output shaft 311 moves to a set stroke, it indicates that the pipette tip 50 has been completely disengaged from the pipetting assembly 20, after which the second drive member 31 moves up to reset.

In the description of the embodiments of the present utility model, it should be noted that, the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like refer to the orientation or positional relationship described based on the drawings, which are merely for convenience of description and simplification of the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present utility model.

The above disclosure is only a preferred embodiment of the present utility model, and it should be understood that the scope of the utility model is not limited thereto, but all or part of the procedures for implementing the above embodiments can be modified by one skilled in the art according to the scope of the appended claims.

Claims (20)

1. A pipette, comprising:

the bracket comprises a supporting vertical plate and a supporting transverse plate which are connected;

the liquid transferring component is arranged on the supporting vertical plate and is used for being detachably connected with the suction head, and the liquid transferring component is also used for driving the suction head to absorb or spit liquid;

the head withdrawing assembly is arranged on the supporting transverse plate and is used for pushing the suction head to be separated from the pipetting assembly.

2. The pipette of claim 1 wherein said pipette assembly comprises a first drive member, a piston cylinder, a piston and an adapter, said piston cylinder having a receiving cavity in which said piston is received, said first drive member being connected to said piston to drive said piston to move in said receiving cavity, said adapter being connected at one end of said piston cylinder, said adapter being for removable connection with said tip, said adapter having an air flow channel in communication with said receiving cavity and said tip.

3. The pipette of claim 2 wherein an end of the piston cylinder facing away from the adapter has an opening communicating with the receiving chamber, the piston extending into the receiving chamber through the opening.

4. The pipette of claim 3 wherein the pipetting assembly further comprises a piston cover plate, the piston cover plate covering the opening, the piston cover plate having a passage hole therethrough, the piston passing through the passage hole.

5. The pipette of claim 4 wherein said opening of said piston cylinder is a stepped bore having a first seal disposed therein, said piston cover plate compressing said first seal, said first seal being in close contact with an outer peripheral surface of said piston.

6. The pipette of claim 2 wherein the pipette assembly further comprises a rail and a slider, the rail being fixedly connected to the support riser, the slider being slidably connected to the rail, the slider being further connected to the first drive member and the piston, the first drive member driving the slider to move on the rail, the slider driving the piston to move in the receiving chamber.

7. The pipette of claim 6 wherein the pipetting assembly further comprises a adapter connected between the slider and the piston, the piston being ceramic.

8. The pipette of claim 2 wherein the first drive is a linear motor and an output shaft of the first drive is connected to the piston; the output shaft of the first driving piece, the piston and the adapting piece all extend along a straight line and are positioned on the same extension straight line.

9. The pipette of claim 2 wherein said support riser is connected to and intersecting said support cross-plate; the piston cylinder is connected with the supporting vertical plate, a first through hole is formed in the supporting transverse plate, the piston cylinder is provided with a matching hole communicated with the first through hole and the accommodating cavity, a first matching part is arranged at one end of the adapting piece, and the first matching part penetrates through the first through hole and is detachably matched and connected with the matching hole.

10. The pipette of claim 9 wherein a second seal ring is disposed between the first mating portion and the mating hole.

11. A pipette according to claim 2, wherein the end of the adapter remote from the piston cylinder is provided with a second mating part for detachable connection with the suction head.

12. The pipette of claim 11 wherein said second mating portion comprises two annular projections spaced apart in the axial direction of said adapter, both of said annular projections having an outer diameter greater than the inner diameter of said tip.

13. The pipette of any one of claims 1-12 wherein the retraction assembly comprises a second drive member, a guide post and a push rod, the guide post being slidably connected to the support cross plate, one end of the guide post being connected to the push rod, the other end of the guide post being capable of abutting or separating from the second drive member; the second driving piece is used for pushing the guide post to move, the guide post drives the push rod to move, and the push rod pushes the suction head to be separated from the pipetting component.

14. The pipette of claim 13 wherein said push rod extends beyond said support cross plate by a length greater than said pipette assembly extends beyond said support cross plate when said pipette tip is not connected to said pipette assembly, said push rod first contacting and retracting with said pipette tip during connection of said pipette tip to said pipette assembly, said pipette assembly then contacting and connecting with said pipette tip.

15. The pipette of claim 13 wherein the support cross plate has a second through hole and the guide post is disposed through the second through hole and is slidable in the second through hole; a shaft shoulder is arranged at one end of the guide post, which is abutted against the second driving piece, the shaft shoulder is positioned outside the second through hole, and the size of the shaft shoulder is larger than the inner diameter of the second through hole; one end of the guide post, which is far away from the shaft shoulder, passes through the second through hole and is connected with the push rod.

16. The pipette of claim 15 wherein the head withdrawal assembly further comprises an elastic member located in the second through hole and sleeved on the outer periphery of the guide post, opposite ends of the elastic member being respectively used for abutting against the push rod and the top wall of the second through hole;

the elastic piece is in a compression state all the time and is switched between a first compression state and a second compression state, when the elastic piece is in the first compression state, the suction head is not connected with the pipetting module, and when the elastic piece is in the second compression state, the suction head is connected with the pipetting module.

17. The pipette of claim 15 wherein the retraction assembly further comprises a support block fixedly connected to the support cross plate, the second drive member being fixed to the support block; the support block is provided with an accommodating space, a third through hole and a fourth through hole which are communicated with the accommodating space, and an output shaft of the second driving piece can sequentially pass through the third through hole and the fourth through hole to be abutted with the guide post;

The fourth through hole is a step hole, one end of the guide pillar, which is far away from the shaft shoulder, sequentially penetrates through the fourth through hole and the second through hole to be connected with the push rod, and the shaft shoulder is used for being abutted to the step surface of the fourth through hole.

18. The pipette of claim 13 wherein the push rod comprises a cross rod and a vertical rod, wherein one end of the cross rod is fixedly connected with one end of the guide post far away from the second driving piece, one end of the vertical rod is connected with one end of the cross rod far away from the guide post, and the extending direction of the vertical rod is the same as the extending direction of the adapter of the pipette assembly; the vertical rod is provided with a sliding hole, the adapting piece is arranged in the sliding hole in a penetrating mode and can slide in the sliding hole, and the vertical rod moves to push the suction head to be separated from the adapting piece.

19. The pipette of claim 17 wherein the retraction assembly further comprises a second sensing member disposed in the receiving space, a sensing pin disposed on the shoulder, the second sensing member electrically connected to the second control member, the push rod contacting the tip and the push rod pushing the guide post to move, the second sensing member being configured to sense the position of the sensing pin and output a second electrical signal, the second control member determining from the second electrical signal whether the tip is connected in place with the pipette assembly and/or whether the tip is loose.

20. A pipetting device comprising a robotic arm, a pipette as recited in any one of claims 1-19 and a tip, the robotic arm being coupled to the pipette, the robotic arm driving the pipette to move to couple a pipetting assembly of the pipette to the tip; and/or the mechanical arm drives the liquid dispenser to move from an initial position to a target position, so that the suction head performs liquid suction operation at the initial position and performs liquid discharge operation at the target position; and/or the mechanical arm drives the liquid dispenser to move to a recovery position so that the head withdrawing assembly of the liquid dispenser breaks away the suction head from the liquid dispensing assembly.

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