CN114146132A - A topical Chinese medicinal composition for treating vitiligo, and its preparation method - Google Patents
A topical Chinese medicinal composition for treating vitiligo, and its preparation method Download PDFInfo
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Abstract
The application discloses an external traditional Chinese medicine for treating leucoderma, which comprises the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba. The external traditional Chinese medicine for treating the vitiligo has the characteristics of small irritation, easily available raw materials, low price, cooperative contract among the raw materials, low side effect, good safety, quick response and good treatment effect on the vitiligo.
Description
Technical Field
The application relates to the field of external use medicines for treating vitiligo, in particular to an external use traditional Chinese medicine for treating vitiligo and a preparation method thereof.
Background
Vitiligo is a skin disease with acquired skin and mucous membrane depigmentation, is a disease which is frequently seen in the skin cosmetology department, is clinically frequently seen as local or extensive depigmentation, and can be caused by various factors such as hereditary nerves, endocrine, autoimmunity, melanocyte self-destruction and the like independently, and several disease factors can also play a role simultaneously.
The western medicine multi-purpose hormone ointment is used for treating local leucoderma, particularly for skin exposed on the body surface, the common ointment is 0.05 percent of clobetasol propionate or 0.1 percent of triamcinolone acetonide acetate cream, halometasone cream, the multi-purpose ointment is mainly used for treating facial and neck or juvenile leucoderma by using hydrocortisone butyrate or low-efficiency soft hormone of mometasone maleate, the long-term use of the hormone preparation can easily cause the effects of epidermal atrophy, skin folliculitis, epidermal capillary vessel dilation and the like, and the ointment is easy to recur after the drug is stopped.
Therefore, how to improve the curative effect of treating vitiligo and reduce the side effect of treatment has become a problem to be solved by those skilled in the art.
Disclosure of Invention
In order to solve the technical problems, the application provides an external traditional Chinese medicine for treating leucoderma, which can improve the curative effect of treating leucoderma and reduce the side effect of treatment.
The technical scheme provided by the application is as follows:
the application provides an external traditional Chinese medicine for treating leucoderma, which comprises the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba.
Further, in a preferred mode of the invention, the composition comprises the following components in parts by weight: 2-10 parts of realgar, 4-12 parts of sulfur, 0.1-2.1 parts of yellow lead, 0.2-1.8 parts of arisaema consanguineum schott, 0.1-1.5 parts of dried alum, 0.2-1.6 parts of lithargite, 1-12 parts of divaricate saposhnikovia root, 0.3-1.9 parts of lithospermum and 0.4-1.8 parts of eclipta alba.
Further, in a preferred mode of the invention, the composition comprises the following components in parts by weight: 2-9 parts of realgar, 4-10 parts of sulfur, 0.1-1.8 parts of yellow lead, 0.3-1.7 parts of arisaema consanguineum schott, 0.2-1.4 parts of dried alum, 0.2-1.1 parts of lithargite, 2-10 parts of divaricate saposhnikovia root, 0.3-1.4 parts of lithospermum and 0.4-1.5 parts of eclipta alba.
In the invention, the external traditional Chinese medicine for treating leucoderma comprises the following components:
the realgar has the effects of detoxifying, killing parasites, eliminating dampness, eliminating phlegm and preventing malaria, can treat malignant diseases such as herpes zoster, pyogenic infection, skin pruritus and insect bite, such as centipede and venomous snake bite, can be treated by realgar, and can be orally or externally applied to nasal polyp, parotitis, scabies, tinea versicolor, aphtha and impetigo.
Sulfur is sour, warm and toxic in nature, the meridian tropism belongs to the kidney channel and the large intestine channel, sulfur has the effects and effects of detoxifying, killing insects and treating sore by external application, and can be taken orally for supplementing fire, supporting yang and relaxing bowels, the sulfur is usually used for treating scabies, tinea pedis, dorsal furuncle, malignant boil and the like by external application, impotence, cold feet, asthmatic asthma, deficiency cold and constipation by internal application, scabies can be killed by external application, insect pests and noxious pathogens are all noxious, so the sulfur has good detoxifying, killing insects and sore effects by external application, can also be used for drying dampness and relieving itching by external application, is a good product for dermatology, is used for treating scabies, tinea capitis, dorsal furuncle, malignant boil and the like by external application, sulfur enters the kidney channel and can supplement the fire of the kidney channel, and has the effects of supplementing fire, supporting yang and relaxing bowels and is used for treating impotence, cold pain of waist and knees, deficient asthma caused by failure of kidney to receive qi.
The yellow lead has effects of removing toxic substance, promoting granulation, killing parasite and relieving itching, can be used for treating skin diseases such as eczema and impetigo, and also has symptom improving effect on myositis caused by deficiency of both qi and yin and heat generation due to yin deficiency, and has effects of eliminating phlegm, relieving convulsion and removing toxic substance, and can be used for regulating problems such as regurgitation, adverse qi flow, emesis, hematemesis and hemoptysis.
The arisaema with the same property as the traditional Chinese medicine belongs to the medicine for eliminating phlegm, relieving cough and asthma, has the efficacies of eliminating dampness, eliminating phlegm, dispelling wind, relieving spasm, reducing swelling and dissipating binds, can be used for treating diseases such as excessive phlegm and cough caused by damp phlegm and cold phlegm, can also be used for treating diseases such as dizziness, stroke hemiplegia and the like caused by wind phlegm, and can also be used for treating diseases such as carbuncle, abscess, swelling and pain, snake venom bite and the like.
The dried alum has the efficacies of eliminating phlegm, eliminating dampness, stopping diarrhea, stopping bleeding, detoxifying and killing parasites, is used for treating epilepsy, pharyngitis, serious saliva accumulation, hepatitis, jaundice, yellow swelling, stomach ulcer, duodenal ulcer, uterine prolapse, leucorrhea, diarrhea, epistaxis, aphthous stomatitis, hemorrhoid, mange, water, fire, insect injury external use can detoxify and relieve itching, is used for pterygium, hemorrhoids, rectocele, and reduction of acid-cold property of the dried alum, enhances astringency and sore astringing, promotes tissue regeneration, and has the effects of stopping bleeding and removing necrotic tissue, and is mainly used for eczema and eczema, purulence, pruritus vulvae and leukorrhagia, chronic diarrhea, hematochezia, metrorrhagia, epistaxis and nasal polyp.
Lithargyrum has effects of eliminating dampness, killing parasite, removing toxic substance, astringing, and preventing corrosion, and can be used for killing various parasites, treating abdominal pain caused by parasite, and treating oral ulcer and eczema of dermatosis.
Ledebouriella root, radix Saposhnikoviae, with pungent and sweet taste and slightly warm nature, enters bladder, lung, spleen and liver meridians, and is indicated for exterior syndrome of exogenous pathogenic factors, rubella with pruritus, rheumatalgia, tetanus with syndrome of resistance, spleen deficiency with excessive dampness.
The lithospermum has sweet, salty and cold properties, has the effects of cooling blood, promoting blood circulation, detoxifying and promoting eruption, and is mainly used for treating pyocutaneous disease, eczema, water and fire scalds and the like caused by excessive blood heat and toxin, purple black macula, measles without adequate measles.
The eclipta alba has the effects of nourishing liver and kidney, clearing heat and cooling blood and the like, can astringe, stop bleeding and discharge pus, can treat various hematemesis, intestinal hemorrhage and the like, has the effects of killing parasites, reducing swelling and relieving itching, and has obvious effects on skin eczema and the like caused by wind, dampness and heat.
The application also provides a preparation method of the external traditional Chinese medicine for treating leucoderma, which comprises the following steps:
s1, washing 2-9 parts of realgar, 4-10 parts of sulfur, 0.1-1.8 parts of yellow lead, 0.3-1.7 parts of arisaema consanguineum schott, 0.2-1.4 parts of dried alum and 0.2-1.1 parts of lithargite respectively, drying, mixing, grinding and sieving with a 50-100-mesh sieve to obtain first mixed powder;
s2, soaking 2-10 parts of divaricate saposhnikovia root, 0.3-1.4 parts of lithospermum and 0.4-1.5 parts of eclipta alba in clear water at 35-45 ℃ for 10-12h, taking out, then putting into a drying oven at 50-75 ℃ for drying for 0.5-0.8h, cooling, grinding and sieving with a 100-mesh sieve to obtain second mixed medicinal powder;
s3, mixing the first mixed powder obtained in the step S1 and the second mixed powder obtained in the step S2 according to the ratio of 3:1-2 to obtain a third mixed powder;
s4, adding ginger juice into the third mixed medicinal powder obtained in the step S3 according to the mass ratio of 1:1-1.5, uniformly stirring, and preparing the external traditional Chinese medicine for treating leucoderma, wherein the external traditional Chinese medicine for treating leucoderma is firstly wiped on an affected part by using the ginger juice and then is externally applied to the affected part.
Further, in a preferred mode of the present invention, the drying temperature in the step S1 is 60 to 85 ℃.
Further, in a preferred embodiment of the present invention, the amount of the windbreak in step S2 is 5 parts.
Further, in a preferred mode of the present invention, in the step S3, the mixing mass ratio of the first mixed powder to the second mixed powder is 3: 1-1.5.
Further, in a preferred embodiment of the present invention, the ginger juice in step S4 is prepared by squeezing and filtering ginger.
Compared with the prior art, the technical scheme provided by the invention is that the external traditional Chinese medicine for treating leucoderma comprises the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic flow chart of a preparation method of an external traditional Chinese medicine for treating vitiligo according to an embodiment of the present invention.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or be indirectly disposed on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "first," "second," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, as used herein, refer to an orientation or positional relationship indicated in the drawings that is solely for the purpose of facilitating the description and simplifying the description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered as limiting the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "plurality" or "a plurality" means two or more unless specifically limited otherwise.
It should be understood that the structures, ratios, sizes, and the like shown in the drawings are only for illustrative purposes and are not intended to limit the scope of the present disclosure, so that those skilled in the art can understand and read the present disclosure, and the present disclosure is not limited to the conditions and conditions that can be implemented in the present disclosure.
The application provides an external traditional Chinese medicine for treating leucoderma, which comprises the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba.
Compared with the prior art, the external traditional Chinese medicine for treating leucoderma provided by the invention comprises the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba.
Specifically, in the embodiment of the invention, the paint comprises the following components in parts by weight: 2-10 parts of realgar, 4-12 parts of sulfur, 0.1-2.1 parts of yellow lead, 0.2-1.8 parts of arisaema consanguineum schott, 0.1-1.5 parts of dried alum, 0.2-1.6 parts of lithargite, 1-12 parts of divaricate saposhnikovia root, 0.3-1.9 parts of lithospermum and 0.4-1.8 parts of eclipta alba.
Specifically, in the embodiment of the invention, the paint comprises the following components in parts by weight: 2-9 parts of realgar, 4-10 parts of sulfur, 0.1-1.8 parts of yellow lead, 0.3-1.7 parts of arisaema consanguineum schott, 0.2-1.4 parts of dried alum, 0.2-1.1 parts of lithargite, 2-10 parts of divaricate saposhnikovia root, 0.3-1.4 parts of lithospermum and 0.4-1.5 parts of eclipta alba.
Compared with the prior art, the external traditional Chinese medicine for treating leucoderma provided by the invention comprises the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba.
As shown in fig. 1, the present application further provides a preparation method of an external traditional Chinese medicine for treating vitiligo, comprising the following steps:
s1, washing 2-9 parts of realgar, 4-10 parts of sulfur, 0.1-1.8 parts of yellow lead, 0.3-1.7 parts of arisaema consanguineum schott, 0.2-1.4 parts of dried alum and 0.2-1.1 parts of lithargite respectively, drying, mixing, grinding and sieving with a 50-100-mesh sieve to obtain first mixed powder;
s2, soaking 2-10 parts of divaricate saposhnikovia root, 0.3-1.4 parts of lithospermum and 0.4-1.5 parts of eclipta alba in clear water at 35-45 ℃ for 10-12h, taking out, then putting into a drying oven at 50-75 ℃ for drying for 0.5-0.8h, cooling, grinding and sieving with a 100-mesh sieve to obtain second mixed medicinal powder;
s3, mixing the first mixed powder obtained in the step S1 and the second mixed powder obtained in the step S2 according to the ratio of 3:1-2 to obtain a third mixed powder;
s4, adding ginger juice into the third mixed medicinal powder obtained in the step S3 according to the mass ratio of 1:1-1.5, uniformly stirring, and preparing the external traditional Chinese medicine for treating leucoderma, wherein the external traditional Chinese medicine for treating leucoderma is firstly wiped on an affected part by using the ginger juice and then is externally applied to the affected part.
It should be added that, in the embodiment of the present invention, 5 parts of realgar are used in the step S1.
It should be noted that, in the embodiment of the present invention, the sulfur in step S1 is 5 parts.
It should be added that, in the embodiment of the present invention, the yellow lead in the step S1 is 1 part.
It should be added that, in the embodiment of the present invention, the rhizoma arisaematis in step S1 is 1 part.
It should be added that, in the embodiment of the present invention, the amount of the calcined alum in the step S1 is 1 part.
It should be added that, in the embodiment of the present invention, 1 part of litharge is used in the step S1.
Specifically, in the embodiment of the present invention, the drying temperature in step S1 is 60 to 85 ℃.
It should be added that, in the embodiment of the present invention, the drying time in the step S1 is 0.3 to 0.7 h.
Specifically, in the embodiment of the present invention, the amount of the windbreak in step S2 is 5 parts.
It should be added that, in the embodiment of the present invention, the soaking time in the step S2 is 10.5 h.
It should be added that, in the embodiment of the present invention, the drying time in the step S2 is 0.6 h.
In the present embodiment, the amount of arnebia root in step S2 is 1 part.
It should be added that, in the embodiment of the present invention, the eclipta alba in the step S2 is 1 part.
More specifically, the external traditional Chinese medicine for treating leucoderma comprises the following components in parts by weight: 5 parts of realgar, 5 parts of sulfur, 1 part of yellow lead, 1 part of arisaema, 1 part of dried alum, 1 part of lithargite, 5 parts of divaricate saposhnikovia root, 1 part of lithospermum and 1 part of eclipta alba.
Specifically, in the embodiment of the present invention, the mixing mass ratio of the first mixed powder to the second mixed powder in step S3 is 3: 1-1.5.
It should be added that, in the embodiment of the present invention, the mixing mass ratio of the first mixed medicinal powder to the second mixed medicinal powder in the step S3 is 3: 1.1.
Specifically, in the embodiment of the present invention, the ginger juice in step S4 is obtained by squeezing and filtering ginger.
More specifically, the preparation method of the ginger juice in the step S4 includes: cleaning rhizoma Zingiberis recens, slicing, squeezing, and filtering with 10 mesh sieve to obtain rhizoma Zingiberis recens juice.
It should be noted that, in the embodiment of the present invention, the mass ratio of the third mixed powder to the ginger juice in the step S4 is 1: 1.3.
In order to better illustrate the treatment effect of the external traditional Chinese medicine for treating vitiligo in the embodiment of the invention, the preparation of the external traditional Chinese medicine for treating vitiligo is exemplified and verified by configuring the components with different weight proportions:
example 1:
the embodiment provides an external traditional Chinese medicine for treating vitiligo, which is prepared by respectively cleaning 1 part of realgar, 2 parts of sulfur, 0.1 part of yellow lead, 0.2 part of arisaema consanguineum schott, 0.1 part of dried alum and 0.2 part of lithargite, mixing, drying at the temperature of 60-85 ℃, grinding, sieving with a 50-100-mesh sieve to obtain first mixed medicinal powder, soaking 5 parts of divaricate saposhnikovia root, 0.3 part of lithospermum, and 0.4 part of eclipta alba for 1.5 hours, fishing out, placing in a drying oven at the temperature of 50-75 ℃ for drying for 0.6 hours, cooling, grinding, sieving with a 100-mesh sieve to obtain second mixed medicinal powder, mixing the first mixed medicinal powder and the second mixed medicinal powder according to the ratio of 3:1.1 to obtain third mixed medicinal powder, adding ginger juice into the third mixed medicinal powder according to the mass ratio of 1:1.3, and uniformly stirring to obtain the external traditional Chinese medicine for treating vitiligo, wherein the first external traditional Chinese medicine is marked as the first external traditional Chinese medicine.
Example 2:
the embodiment provides an external traditional Chinese medicine for treating vitiligo, which is prepared by respectively cleaning 5 parts of realgar, 5 parts of sulfur, 1 part of yellow lead, 1 part of arisaema consanguineum, 1 part of dried alum and 1 part of lithargite, mixing, drying at the temperature of 60-85 ℃, grinding, sieving with a 50-100-mesh sieve to obtain a first mixed medicinal powder, soaking 5 parts of divaricate saposhnikovia root, 1 part of lithospermum and 1 part of eclipta alba for 1.5h, fishing out, placing in a drying oven at the temperature of 50-75 ℃ for drying for 0.6h, cooling, grinding, sieving with a 100-mesh sieve to obtain a second mixed medicinal powder, mixing the first mixed medicinal powder and the second mixed medicinal powder according to the proportion of 3:1.1 to obtain a third mixed medicinal powder, adding ginger juice into the third mixed medicinal powder according to the mass ratio of 1:1.3, and uniformly stirring to obtain the external traditional Chinese medicine for treating vitiligo, and marking as the second external traditional Chinese medicine.
Example 3:
the embodiment provides an external traditional Chinese medicine for treating vitiligo, which is prepared by respectively cleaning 9 parts of realgar, 10 parts of sulfur, 1.8 parts of yellow lead, 1.7 parts of arisaema consanguineum schott, 1.4 parts of dried alum and 1.1 parts of lithargite, mixing, drying at the temperature of 60-85 ℃, grinding, sieving with a 50-100-mesh sieve to obtain first mixed medicinal powder, soaking 5 parts of divaricate saposhnikovia root, 1.4 parts of lithospermum, and 1.5 parts of eclipta alba for 1.5 hours, fishing out, placing in a drying oven at the temperature of 50-75 ℃ for drying for 0.6 hours, cooling, grinding, sieving with a 100-mesh sieve to obtain second mixed medicinal powder, mixing the first mixed medicinal powder and the second mixed medicinal powder according to the ratio of 3:1.1 to obtain third mixed medicinal powder, adding ginger juice into the third mixed medicinal powder according to the mass ratio of 1:1.3, and uniformly stirring to obtain the external traditional Chinese medicine for treating vitiligo, and marking as the third external traditional Chinese medicine.
Example 4:
a proper amount of external western medicines suitable for treating vitiligo (such as tacrolimus ointment of 0.1%) is selected as a fourth external traditional Chinese medicine.
80 patients were selected and randomized into four groups, all of which met the diagnostic criteria and inclusion criteria and were not within the exclusion criteria.
Diagnostic criteria:
1) the traditional Chinese medicine diagnosis standard is as follows: according to the traditional Chinese medicine syndrome differentiation, the traditional Chinese medicine belongs to qi stagnation and blood stasis, and has the symptoms of skin leukoplakia, ecchymosis and petechia on the tongue tip edge and slow pulse;
2) the skin damage has clear boundary and irregular shape, the hair in the skin damage can be whitened or the color of the periphery of the hair follicle opening is compounded, the pigment at the edge of the skin damage is deepened, the hair-spreading type develops from the scattering nature, the white spots are numerous, and the hair-spreading type is combined into irregular large sheets, the scattering nature is the scattering or multiple white spots which are usually distributed symmetrically, and the limitation is that the single hair or multiple white spots are limited to a certain part.
Inclusion criteria were: the diagnostic standard is met; the physical treatment of leucoderma and the ultra-long wave or medium wave ultraviolet treatment are not used in about 1 month; age 18-60 years; signing the informed consent.
Exclusion criteria: malignant skin tumor such as malignant melanoma and squamous cell carcinoma; severe dysfunction of the lung, kidney, liver, heart, etc.; with other intractable skin diseases such as psoriasis, eczema and neurodermatitis; pregnant or lactating women; allergic constitution.
The information for each group of patients is as follows:
experiment group one: 11 men, 9 women, 18-58 years old, mean (34.28 + -6.32) years old, 1-8 years course of disease, mean (5.42 + -1.02) years old, 7 generalized cases, 8 sporadic cases, 5 limited cases; experiment group two: 10 male cases, 10 female cases, age 18-59 years, mean (34.28 + -6.41) years, course 1-9 years, mean (5.42 + -1.32) years, 7 generalized cases, 9 sporadic cases, 4 limited cases; experiment group three: 10 male cases, 10 female cases, age 19-58 years, mean (35.26 + -6.12) years, course 1-10 years, mean (5.42 + -1.42) years, generalized 6 cases, sporadic 8 cases, and limited 6 cases; experiment group four: 9 men, 11 women, 19-59 years old, mean (34.28 +/-6.32) years old, 1-9 years of course, mean (5.69 +/-1.52) years old, 8 generalized cases, 8 sporadic cases and 4 limited cases, wherein the general data of the four groups are compared, have no statistical significance and are comparable.
Observation indexes are as follows: observing the change condition before and after the skin lesion area treatment and the occurrence condition of adverse reaction.
The curative effect standard is as follows:
1) and curing: white spots disappear completely, and the skin color returns to normal;
2) and (3) effect is shown: the white spots are obviously removed, and the area of recovered normal skin color accounts for more than 50% of the area of skin damage;
3) and effective: white spots disappear, and skin color returns to normal and occupies less than 50% of the area of skin damage;
4) and (3) invalidation: white spots and skin color were not improved.
The patient of experiment group I wipes the affected part with ginger juice first, and then the first external traditional Chinese medicine is externally applied to the affected part twice in the morning and evening, the patient of experiment group II wipes the affected part with ginger juice first, and then the second external traditional Chinese medicine is externally applied to the affected part, twice in the morning and evening, the patient of experiment group III wipes the affected part with ginger juice first, and then the third external traditional Chinese medicine is externally applied to the affected part, twice in the morning and evening, the patient of experiment group II uses the fourth external traditional Chinese medicine to be applied to the affected part, twice in the morning and evening, the treatment cycle of the four groups is 12 weeks, the treatment results are as shown in table 1 four groups of skin damage area comparison tables before and after treatment and table 2 four groups of clinical efficacy comparison tables before and after treatment.
TABLE 1 comparison table of skin damage area before and after four treatments
| Group of | n | Before treatment | Before treatment |
| Experiment set 1 | 20 | 50.81±4.56 | 31.71±2.19 |
| Experiment group two | 20 | 51.81±4.26 | 24.13±3.42 |
| Experiment group III | 20 | 50.72±4.86 | 29.43±4.05 |
| Experiment group four | 20 | 51.03±4.37 | 37.62±4.59 |
TABLE 2 comparison table of clinical effects before and after four groups of treatments
| Group of | n | Cure of disease | Show effect | Is effective | Invalidation | Total effective rate |
| Experiment set 1 | 20 | 6(30％) | 4(20％) | 5(25％) | 5(25％) | 75％ |
| Experiment group two | 20 | 9(45％) | 6(30％) | 3(15％) | 2(10％) | 90％ |
| Experiment group III | 20 | 7(35％) | 5(25％) | 4(20％) | 4(20％) | 80％ |
| Experiment group four | 20 | 4(20％) | 5(25％) | 5(25％) | 6(30％) | 70％ |
Through the observation results of the above 80 patients, 26 cases are cured, 20 cases are treated with significant effect, 17 cases are treated with effective effect, and 17 cases are treated with ineffective effect, and the above 80 patients have no adverse reaction during the treatment period and after the drug is stopped, because the difference of the self physical quality of each patient is difficult to ensure that the experimental conditions are completely consistent, the above experimental data have certain errors, but the final experimental result is not affected, as can be seen from table 1 and table 2, the treatment effect of the experimental group four is obviously lower than that of the experimental group one, the experimental group two and the experimental group three, that is, the treatment effect of the external traditional Chinese medicine for treating vitiligo related to the application is wholly greater than that of the external western medicine 0.1% tacrolimus ointment in the embodiment 4, and the size relationship of each treatment effect is as follows: the second external traditional Chinese medicine > the third external traditional Chinese medicine > the first external traditional Chinese medicine, so the components of the raw materials in the embodiment 2 of the application are in the proportion with the optimal effect.
Therefore, the external traditional Chinese medicine for treating the vitiligo comprises the following components in parts by weight: 5 parts of realgar, 5 parts of sulfur, 1 part of yellow lead, 1 part of arisaema, 1 part of dried alum, 1 part of lithargite, 5 parts of divaricate saposhnikovia root, 1 part of lithospermum and 1 part of eclipta alba, and the effect of treating leucoderma is most obvious.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. An external traditional Chinese medicine for treating leucoderma is characterized by comprising the following components in parts by weight: 1-12 parts of realgar, 2-15 parts of sulfur, 0.1-3.2 parts of yellow lead, 0.2-2.5 parts of arisaema consanguineum, 0.1-1.9 parts of dried alum, 0.2-2.1 parts of lithargite, 1-17 parts of divaricate saposhnikovia root, 0.3-3 parts of lithospermum and 0.4-2.2 parts of eclipta alba.
2. The external traditional Chinese medicine for treating leucoderma according to claim 1, which comprises the following components in parts by weight: 2-10 parts of realgar, 4-12 parts of sulfur, 0.1-2.1 parts of yellow lead, 0.2-1.8 parts of arisaema consanguineum schott, 0.1-1.5 parts of dried alum, 0.2-1.6 parts of lithargite, 1-12 parts of divaricate saposhnikovia root, 0.3-1.9 parts of lithospermum and 0.4-1.8 parts of eclipta alba.
3. The external traditional Chinese medicine for treating leucoderma according to claim 2, which comprises the following components in parts by weight: 2-9 parts of realgar, 4-10 parts of sulfur, 0.1-1.8 parts of yellow lead, 0.3-1.7 parts of arisaema consanguineum schott, 0.2-1.4 parts of dried alum, 0.2-1.1 parts of lithargite, 2-10 parts of divaricate saposhnikovia root, 0.3-1.4 parts of lithospermum and 0.4-1.5 parts of eclipta alba.
4. The preparation method of the externally applied traditional Chinese medicine for treating vitiligo according to claim 3, which comprises the following steps:
s1, washing 2-9 parts of realgar, 4-10 parts of sulfur, 0.1-1.8 parts of yellow lead, 0.3-1.7 parts of arisaema consanguineum schott, 0.2-1.4 parts of dried alum and 0.2-1.1 parts of lithargite respectively, drying, mixing, grinding and sieving with a 50-100-mesh sieve to obtain first mixed powder;
s2, soaking 2-10 parts of divaricate saposhnikovia root, 0.3-1.4 parts of lithospermum and 0.4-1.5 parts of eclipta alba in clear water at 35-45 ℃ for 10-12h, taking out, then putting into a drying oven at 50-75 ℃ for drying for 0.5-0.8h, cooling, grinding and sieving with a 100-mesh sieve to obtain second mixed medicinal powder;
s3, mixing the first mixed powder obtained in the step S1 and the second mixed powder obtained in the step S2 according to the ratio of 3:1-2 to obtain a third mixed powder;
s4, adding ginger juice into the third mixed medicinal powder obtained in the step S3 according to the mass ratio of 1:1-1.5, uniformly stirring, and preparing the external traditional Chinese medicine for treating leucoderma, wherein the external traditional Chinese medicine for treating leucoderma is firstly wiped on an affected part by using the ginger juice and then is externally applied to the affected part.
5. The method for preparing the topical Chinese medicine for treating vitiligo according to claim 4, wherein the drying temperature in the step S1 is 60-85 ℃.
6. The method for preparing an externally-applied traditional Chinese medicine for treating vitiligo according to claim 5, wherein the ledebouriella root in the step S2 is 5 parts.
7. The method for preparing an externally-applied traditional Chinese medicine for treating vitiligo according to claim 6, wherein the mixing mass ratio of the first mixed powder and the second mixed powder in the step S3 is 3: 1-1.5.
8. The method for preparing an externally-applied Chinese medicine for treating vitiligo according to claim 7, wherein the ginger juice in the step S4 is prepared by squeezing and filtering ginger.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406698A (en) * | 2011-07-11 | 2012-04-11 | 李保明 | External medicinal liquid for treating vitiligo |
| CN103830463A (en) * | 2012-11-26 | 2014-06-04 | 青岛信立德中药技术研究开发有限公司 | Externally-applied traditional Chinese medicine for treating leucoderma |
-
2021
- 2021-11-26 CN CN202111422458.2A patent/CN114146132A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406698A (en) * | 2011-07-11 | 2012-04-11 | 李保明 | External medicinal liquid for treating vitiligo |
| CN103830463A (en) * | 2012-11-26 | 2014-06-04 | 青岛信立德中药技术研究开发有限公司 | Externally-applied traditional Chinese medicine for treating leucoderma |
Non-Patent Citations (4)
| Title |
|---|
| 张成阳: "《中国传统医学 偏方大全》", 31 January 2017, 江西科学技术出版社 * |
| 沈丕安: "《中药药理与临床运用 上》", 30 June 2020, 吉林科学技术出版社 * |
| 蔡锦芳: "《济世中医本草解析》", 31 July 2019, 中医古籍出版社 * |
| 陈梅花 等: "中药外用治疗白癜风的临床应用概况", 《中国中西医结合皮肤性病学杂志》 * |
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