CN114131866B - Method for manufacturing vacuum sterile blood erythrocyte sedimentation tube mold - Google Patents
Method for manufacturing vacuum sterile blood erythrocyte sedimentation tube mold Download PDFInfo
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- CN114131866B CN114131866B CN202111447969.XA CN202111447969A CN114131866B CN 114131866 B CN114131866 B CN 114131866B CN 202111447969 A CN202111447969 A CN 202111447969A CN 114131866 B CN114131866 B CN 114131866B
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- 238000004062 sedimentation Methods 0.000 title claims abstract description 60
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 35
- 210000003743 erythrocyte Anatomy 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims description 21
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 238000001816 cooling Methods 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 14
- 239000000498 cooling water Substances 0.000 claims description 12
- 239000003292 glue Substances 0.000 claims description 11
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 238000005266 casting Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 39
- 239000008280 blood Substances 0.000 abstract description 39
- 238000001035 drying Methods 0.000 abstract description 33
- 238000001746 injection moulding Methods 0.000 abstract description 18
- 238000001514 detection method Methods 0.000 abstract description 13
- 238000005516 engineering process Methods 0.000 abstract description 6
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- 238000002347 injection Methods 0.000 description 39
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- 239000000203 mixture Substances 0.000 description 24
- 239000004594 Masterbatch (MB) Substances 0.000 description 17
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- 230000008018 melting Effects 0.000 description 10
- 239000011521 glass Substances 0.000 description 9
- 238000004659 sterilization and disinfection Methods 0.000 description 7
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
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Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/76—Measuring, controlling or regulating
- B29C45/78—Measuring, controlling or regulating of temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
- A61B5/154—Devices using pre-evacuated means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/27—Sprue channels ; Runner channels or runner nozzles
- B29C45/2737—Heating or cooling means therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/40—Removing or ejecting moulded articles
- B29C45/4005—Ejector constructions; Ejector operating mechanisms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/72—Heating or cooling
- B29C45/73—Heating or cooling of the mould
- B29C45/7312—Construction of heating or cooling fluid flow channels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C2045/0096—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor drying the moulding material before injection, e.g. by heating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
- B29C2945/76—Measuring, controlling or regulating
- B29C2945/76494—Controlled parameter
- B29C2945/76531—Temperature
Abstract
The invention discloses a production process of a vacuum sterile blood erythrocyte sedimentation tube and a die manufacturing method, belonging to the technical field of clinical medical equipment, wherein the vacuum sterile blood erythrocyte sedimentation tube is provided with a tube body, the upper end of the tube body is connected with a safety protection cap, the cross section of the sedimentation tube is of a cylindrical structure, the outer circumference of the sedimentation tube is provided with scales, and the tube body is provided with a liquid level indication mark; the processing technology of the vacuum sterile blood erythrocyte sedimentation tube comprises the following steps: proportioning, drying and crystallizing, dehumidifying, exhausting air and injection molding. The invention has simple structure, simplified production process, low production cost, greatly improved safety use performance of the product, strong manufacturing stability of the blood sedimentation tube, shortened production period, reduced use defects and high efficiency detection of human blood sedimentation rate.
Description
Technical Field
The invention relates to the technical field of clinical medical instruments, in particular to a production process of a vacuum sterile blood erythrocyte sedimentation tube and a die manufacturing method.
Background
The detection of blood samples is a conventional technical means of clinical examination in medical institutions, wherein the detection of venous blood samples is widely applied to detection of biochemical indexes, hemagglutination indexes, hemorheology indexes, blood routine analysis, analysis of trace elements and ion components, detection of nutritional components, detection of drug concentration, gene detection, detection of etiology of infectious diseases, detection of microorganisms and the like. The common vacuum test tube in prior art market comprises heparin tube body, plug and skull, additive, label etc. and the material is mostly glass and plastic tubing, nevertheless because the glass tube has very big hidden danger in the security performance, uses special plastics PET test tube to replace the glass tube to become a development trend.
The glass blood sedimentation tube in the prior art has the following defects: 1. the glass material is fragile, if the blood sedimentation tube is broken before blood collection, the vacuum loss in the tube can cause failure in blood sample collection, if the glass tube is broken after blood collection, the blood of a patient is easy to spill and leak, the environment is polluted, medical staff can be injured, the patient needs to be subjected to secondary blood collection, and the patient is easy to be injured; 2. the glass material can not carry out sterilization treatment, and the additive in the blood sedimentation tube belongs to the bacterial growth auxiliary agent moreover, if do not carry out sterilization treatment to the product, in the in-process of gathering blood, once blood refluxes, the bacterium gets into the patient internal, can cause very serious influence.
Disclosure of Invention
The invention aims at the technical problems in the prior art and provides a production process of a vacuum sterile blood erythrocyte sedimentation tube and a die manufacturing method.
In order to solve the technical problem, the invention provides a vacuum sterile blood erythrocyte sedimentation tube which is provided with a tube body, wherein the upper end of the tube body is connected with a safety protection cap, the cross section of the sedimentation tube is of a cylindrical structure, scales are arranged on the outer circumference of the sedimentation tube, and a liquid level indication mark is arranged on the tube body.
Preferably, the length of the pipe body is not less than 100mm, and the perpendicularity between the pipe wall of the pipe body and the pipe orifice of the pipe body is less than or equal to 0.2mm.
Preferably, the body of the blood sedimentation tube is made of PET material.
The invention also provides a production process of the vacuum sterile blood erythrocyte sedimentation tube, which comprises the following steps:
1) Preparing materials: adding the master batch into the PET base stock, and uniformly mixing to obtain a mixture;
2) Drying and crystallizing: putting the mixture obtained in the step 1) into a drying box, heating for 4-6h at 160-170 ℃, sampling, detecting whether the mixture is completely crystallized by using a light transmission device, starting the stirring function of the drying box when a tiny uncrystallized part exists in the mixture, stirring for 15-20min, and then drying again at the drying temperature of 160-170 ℃ for 1.5-2h to obtain a crystallized material;
3) And (3) dehumidification: transferring the crystallized material in the step 2) into a dehumidifier, and controlling the rotating speed at 300-350r/min and the dehumidifying time at 30min;
4) Air exhaust: starting an exhaust fan, controlling the rotating speed to be 750-800r/min, and removing the micro-dust in the crystallization material, wherein the exhaust time is 10min;
5) Injection molding: selecting a large power system and a PET special screw multi-section temperature control injection molding machine, carrying out multi-temperature section temperature control, controlling the temperature of one section to be 282-288 ℃, the temperature of two sections to be 272-278 ℃, the temperature of three sections to be 267-273 ℃, the temperature of four sections to be 267-273 ℃ and the temperature of five sections to be 267-273 ℃, jetting the molten liquid into a mold at high speed through a nozzle under high pressure, then rapidly cooling the mold by using cooling water, and opening the mold to obtain a high-transparency vacuum blood sedimentation tube finished product.
Preferably, step 1) is specifically: the production technology of a special PET polyester base material with the viscosity range of 0.5-0.7dl/g and a master batch is adopted, the master batch is added into the PET base material in a proportion of 1-10%, the shear viscosity is controlled to be less than or equal to 75Pa.S, and the oxygen transmission rate is less than or equal to 3.0cc (m 2 star day) under the conditions of 275 ℃ and the shear rate of 1200S < -1 >.
Preferably, the temperature of the normal temperature water of the front mold of the mold in the step 5) is 25 ℃, and the temperature of the cold water of the rear mold is 15 ℃.
Preferably, the temperature of the molten gel in the step 5) is controlled to be 270-295 ℃, the injection is completed within 4s, and the back pressure does not exceed 100bar.
The invention also provides a vacuum sterile blood erythrocyte sedimentation tube, the die comprises a front die insert, a front die insert core, a push plate insert sleeve and a rear die insert core, the die comprises seven systems which are respectively: the device comprises a pouring system, a cooling system, an ejection system, a guide system, a forming system, a positioning system and a supporting system; the mould adopts a needle valve type multi-point side glue feeding mode, the point position glue feeding is 1-10 points, the heating mode adopts a heater, a temperature sensing line and a heat nozzle body which are integrally designed, a copper pipe heater is used, and a special temperature control box is adopted to embed a PID function; the cooling system adopts fountain type cooling system, and the cooling water of the rear mould insert core is sent to the mould through the water pipe after being cooled by the water chiller.
Preferably, the mold is selected from two-plate mold, three-plate mold and hot runner, and the glue feeding mode adopts a middle-lower section glue feeding mode with one point side.
Preferably, a curved water path cooling mode is adopted in the cooling system, and the cooling water channel is formed by feeding water from the middle, discharging water from the periphery and returning the water to the water cooler.
Preferably, the ejection system adopts an outer periphery push plate ejection system, the ejection process adopts multi-section positioning, the ejection system is provided with a material handle, and the material handle is provided with an elastic block.
Preferably, the gating system adopts exhaust steel, the exhaust steel is used for exhausting, and the top surface of the die, which is easy to trap air, is inlaid for exhaust.
Compared with the prior art, the invention has the following beneficial effects:
the invention has simple structure, because the body of the blood sedimentation tube is internally provided with the detection additive, and the body is internally preset with quantitative vacuum, when the body and the blood vessel form a connecting channel, blood is quantitatively led into the tank body by using quantitative pressure difference, and the quantitative blood reacts with the detection additive in the body, thereby detecting the blood sedimentation rate of the human body; and the PET material's body structure, the shortcoming that glass material can not carry out sterilization process is changed, can carry out disinfection and sterilization process high-efficiently, and is safe in utilization.
The invention simplifies the production process, has low production cost, greatly improves the safe use performance of the product, extends the use depth of the blood sedimentation tube, has strong manufacturing stability of the blood sedimentation tube and ensures that the manufactured product is smoother and more beautiful; but also can shorten the production period, reduce the use defects and efficiently detect the human blood sedimentation rate.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.
FIG. 1 is a schematic view of the structure of a blood sedimentation tube according to the present invention;
FIG. 2 is a schematic front view of the blood sedimentation tube body according to the present invention;
fig. 3 is a schematic structural view of the blood sedimentation tube mold of the present invention.
The symbols in the figures indicate:
1. a pipe body; 2. a front mold insert; 3. embedding a core in a front mold; 4. embedding a push plate; 5. and (5) embedding the core in the rear mold.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present application clearer, the present application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of and not restrictive on the broad application.
As shown in fig. 1 and fig. 2, the invention provides a vacuum sterile blood erythrocyte sedimentation tube (hereinafter referred to as blood sedimentation tube) for detecting ESR, which is provided with a tube body 1, wherein the cross section of the tube body 1 is of a cylindrical structure, the upper end of the tube body 1 is connected with a safety protection cap, and the inner side of the safety protection cap is provided with a sealing plug; the body 1 is provided with a liquid level indicating mark, and the outer circumference of the blood sedimentation tube is also provided with scales, so that data reading is facilitated.
Furthermore, in the present embodiment, the material of the blood sedimentation tube body 1 is PET.
Furthermore, in this embodiment, the length of the tube body 1 of the blood sedimentation tube is not less than 100mm, and the tube wall of the tube body 1 is perpendicular to the cross section of the tube opening of the tube body 1 or the verticality is less than or equal to 0.2mm.
As another preferred embodiment of this embodiment, the material of the blood sedimentation tube may be another plastic material having equivalent properties that can maintain the vacuum degree.
The operating principle of the blood sedimentation tube is as follows: because the inside of the blood sedimentation tube body is stored with the detection additive, the inside of the tube body 1 is preset with quantitative vacuum, when a connecting channel is formed between the tube body 1 and a blood vessel, blood is quantitatively led into the tank body by utilizing quantitative pressure difference, and the quantitative blood reacts with the detection additive in the tube body 1, so that the blood sedimentation rate of a human body is detected.
The PET material pipe body structure changes the defect that the glass material can not be sterilized, can efficiently perform disinfection and sterilization treatment, and is safe to use.
The first embodiment is as follows:
the invention also provides a production process of the vacuum sterile blood erythrocyte sedimentation tube, which comprises the following steps:
1) Preparing materials: the method comprises the following steps of (1) adding a special PET polyester base material with the viscosity range of 0.5-0.7dl/g and a master batch into the PET base material according to the proportion of 1% -10%, controlling the shear viscosity to be less than or equal to 75Pa.S and the oxygen transmission rate to be less than or equal to 3.0cc (m 2 star) under the conditions of 275 ℃ and the shear rate of 1200S < -1 >, and uniformly mixing the master batch with the base material to obtain a mixture;
2) Drying and crystallizing: putting the mixture obtained in the step 1) into a drying box, heating for 6h at 160 ℃, sampling, detecting whether the mixture is completely crystallized by using a light transmission device, starting the stirring function of the drying box when a tiny uncrystallized part exists in the mixture, stirring for 20min, and then drying again at the drying temperature of 170 ℃ for 2h to obtain a crystallized material;
3) And (3) dehumidification: transferring the crystallized material in the step 2) into a dehumidifier, controlling the rotating speed at 300r/min, and dehumidifying for 30min;
4) Air exhaust: starting an exhaust fan, controlling the rotating speed to be 750r/min, and removing the micro-dust in the crystallization material, wherein the exhaust time is 10min;
5) Injection molding: selecting a large power system and a PET special screw multi-section temperature control injection molding machine, and carrying out multi-temperature section temperature control; the temperature of normal temperature water of a front mold of the mold is 25 ℃, and the temperature of cold water of a rear mold is 15 ℃; heating temperature: the first section is controlled to 288 ℃, the second section is 278 ℃, the third section is 273 ℃, the fourth section is 273 ℃ and the fifth section is 273 ℃, the molten liquid is sprayed into the die at high speed through the nozzle under high pressure, then the die is rapidly cooled by cooling water, and the die is opened to obtain the finished product of the high-transparency vacuum sedimentation tube.
The injection molding process comprises the following steps: because the PET has short stabilization time after the melting point and the melting point is higher, an injection system with more temperature control sections and less self-friction heat generation during plasticization needs to be selected, and the actual weight of a product (water-containing mouth material) cannot be less than 2/3 of the injection amount of a machine; the melt adhesive temperature can be measured by adopting an air injection method, and is controlled to be 270-295 ℃; the injection speed is high, premature solidification can be prevented during injection, but the material is fragile due to high shearing rate at high speed, so that the injection is controlled to be finished within 4 s; back pressure: generally not exceeding 100bar, is effective in preventing abrasion.
It should be noted that too long a residence time is not used to prevent molecular weight degradation, and temperatures above 300 ℃ are avoided as much as possible; if the machine is stopped for less than 15 minutes, only the idle injection treatment is needed, and if the machine is stopped for more than 15 minutes, the machine is cleaned by using the viscosity PE, and the temperature of the machine barrel is reduced to the temperature of the PE until the machine is started again.
Example two:
the invention also provides a production process of the vacuum sterile blood erythrocyte sedimentation tube, which comprises the following steps:
1) Preparing materials: adding the master batch into the PET base material in a proportion of 1-10% by adopting a special production technology of PET polyester base material and master batch with the viscosity range of 0.5-0.7dl/g, controlling the shear viscosity to be less than or equal to 75Pa.S and the oxygen transmission rate to be less than or equal to 3.0cc (m 2 day) under the conditions of 275 ℃ and the shear rate of 1200S < -1 >, and uniformly mixing the master batch and the base material to obtain a mixture;
2) Drying and crystallizing: putting the mixture obtained in the step 1) into a drying box, heating for 6 hours at 165 ℃, sampling, detecting whether the mixture is completely crystallized by using a light transmission device, starting the stirring function of the drying box when a tiny uncrystallized part exists in the mixture, stirring for 20 minutes, and then drying again, wherein the drying temperature is 165 ℃ and the drying time is 2 hours to obtain a crystallized material;
3) And (3) dehumidification: transferring the crystallized material in the step 2) into a dehumidifier, controlling the rotating speed at 300r/min, and dehumidifying for 30min;
4) Air exhaust: starting an exhaust fan, controlling the rotating speed to be 800r/min, and removing the micro-dust in the crystallization material, wherein the exhaust time is 10min;
5) Injection molding: selecting a large power system and a PET special screw multi-section temperature control injection molding machine, and performing multi-temperature section temperature control; the normal temperature water temperature of the front mold of the mold is 25 ℃, and the cold water temperature of the rear mold is 15 ℃; heating temperature: controlling the temperature of the first section to 282 ℃, the temperature of the second section to 272 ℃, the temperature of the third section to 267 ℃, the temperature of the fourth section to 267 ℃ and the temperature of the fifth section to 267 ℃, jetting the molten liquid into a die at high speed through a nozzle under high pressure, then rapidly cooling the die by using cooling water, and opening the die to obtain a high-transparency finished product of the vacuum sedimentation tube.
The injection molding process comprises the following steps: because the PET has short stabilization time after melting point and higher melting point, an injection system with more temperature control sections and less self-friction heat generation during plasticizing needs to be selected, and the actual weight of a product (water-containing oral material) cannot be less than 2/3 of the injection amount of a machine; the melt adhesive temperature can be measured by adopting an air injection method, and is controlled to be 270-295 ℃; the injection speed is high, premature solidification can be prevented during injection, but the material is fragile due to high shearing rate at the high injection speed, so that the injection is controlled to be completed within 4 s; back pressure: generally not exceeding 100bar, is effective in preventing abrasion.
It should be noted that too long a residence time is not used to prevent molecular weight degradation, and temperatures above 300 ℃ are avoided as much as possible; if the machine is stopped for less than 15 minutes, only the idle injection treatment is needed, and if the machine is stopped for more than 15 minutes, the viscous PE is used for cleaning, and the temperature of the machine barrel is reduced to the PE temperature until the machine is started again.
Example three:
the invention also provides a production process of the vacuum sterile blood erythrocyte sedimentation tube, which comprises the following steps:
1) Preparing materials: adding the master batch into the PET base material in a proportion of 1-10% by adopting a special production technology of PET polyester base material and master batch with the viscosity range of 0.5-0.7dl/g, controlling the shear viscosity to be less than or equal to 75Pa.S and the oxygen transmission rate to be less than or equal to 3.0cc (m 2 day) under the conditions of 275 ℃ and the shear rate of 1200S < -1 >, and uniformly mixing the master batch and the base material to obtain a mixture;
2) Drying and crystallizing: putting the mixture obtained in the step 1) into a drying box, heating for 5 hours at 165 ℃, sampling, detecting whether the mixture is completely crystallized by using a light transmission device, starting the stirring function of the drying box when a tiny uncrystallized part exists in the mixture, stirring for 15 minutes, and then drying again at the drying temperature of 160 ℃ for 2 hours to obtain a crystallized material;
3) And (3) dehumidification: transferring the crystallized material in the step 2) into a dehumidifier, and controlling the rotating speed at 350r/min and the dehumidifying time at 30min;
4) Air exhaust: starting an exhaust fan, controlling the rotating speed to be 800r/min, and removing the micro-dust in the crystallization material, wherein the exhaust time is 10min;
5) Injection molding: selecting a large power system and a PET special screw multi-section temperature control injection molding machine, and performing multi-temperature section temperature control; the normal temperature water temperature of the front mold of the mold is 25 ℃, and the cold water temperature of the rear mold is 15 ℃; heating temperature: the first section of the vacuum sedimentation tube is controlled to be 285 ℃, the second section of the vacuum sedimentation tube is 275 ℃, the third section of the vacuum sedimentation tube is 270 ℃, the fourth section of the vacuum sedimentation tube is 270 ℃, the fifth section of the vacuum sedimentation tube is 270 ℃, the molten liquid is sprayed into a die at high speed through a nozzle under high pressure, then the die is rapidly cooled by cooling water, and the die is opened to obtain a finished product of the vacuum sedimentation tube with high transparency.
The injection molding process comprises the following steps: because the PET has short stabilization time after melting point and higher melting point, an injection system with more temperature control sections and less self-friction heat generation during plasticizing needs to be selected, and the actual weight of a product (water-containing oral material) cannot be less than 2/3 of the injection amount of a machine; the melt adhesive temperature can be measured by adopting an air shot method, and is controlled at 270-295 ℃; the injection speed is high, premature solidification can be prevented during injection, but the material is fragile due to high shearing rate at high speed, so that the injection is controlled to be finished within 4 s; back pressure: generally not exceeding 100bar, is effective in preventing abrasion.
It should be noted that too long a residence time is not used to prevent the molecular weight from decreasing, and temperatures above 300 ℃ are avoided as much as possible; if the machine is stopped for less than 15 minutes, only the idle injection treatment is needed, and if the machine is stopped for more than 15 minutes, the machine is cleaned by using the viscosity PE, and the temperature of the machine barrel is reduced to the temperature of the PE until the machine is started again.
Example four:
the invention also provides a production process of the vacuum sterile blood erythrocyte sedimentation tube, which comprises the following steps:
1) Preparing materials: adding the master batch into the PET base material in a proportion of 1-10% by adopting a special production technology of PET polyester base material and master batch with the viscosity range of 0.5-0.7dl/g, controlling the shear viscosity to be less than or equal to 75Pa.S and the oxygen transmission rate to be less than or equal to 3.0cc (m 2 day) under the conditions of 275 ℃ and the shear rate of 1200S < -1 >, and uniformly mixing the master batch and the base material to obtain a mixture;
2) Drying and crystallizing: putting the mixture obtained in the step 1) into a drying box, heating for 4h at 170 ℃, sampling, detecting whether the mixture is completely crystallized by using a light transmission device, starting the stirring function of the drying box when a tiny uncrystallized part exists in the mixture, stirring for 15min, and then drying again at the drying temperature of 160 ℃ for 2h to obtain a crystallized material;
3) And (3) dehumidification: transferring the crystallized material in the step 2) into a dehumidifier, and controlling the rotating speed at 350r/min and the dehumidifying time at 30min;
4) Air exhaust: starting an exhaust fan, controlling the rotating speed to be 750r/min, and removing the micro-dust in the crystallization material, wherein the exhaust time is 10min;
5) Injection molding: selecting a large power system and a PET special screw multi-section temperature control injection molding machine, and performing multi-temperature section temperature control; the temperature of normal temperature water of a front mold of the mold is 25 ℃, and the temperature of cold water of a rear mold is 15 ℃; heating temperature: controlling the temperature of the first section to be 285 ℃, the temperature of the second section to be 275 ℃, the temperature of the third section to be 270 ℃, the temperature of the fourth section to be 270 ℃ and the temperature of the fifth section to be 270 ℃, jetting the molten liquid into a mould at high speed through a nozzle under high pressure, then rapidly cooling the mould by using cooling water, and opening the mould to obtain a high-transparency finished product of the vacuum blood sedimentation tube.
The injection molding process comprises the following steps: because the PET has short stabilization time after melting point and higher melting point, an injection system with more temperature control sections and less self-friction heat generation during plasticizing needs to be selected, and the actual weight of a product (water-containing oral material) cannot be less than 2/3 of the injection amount of a machine; the melt adhesive temperature can be measured by adopting an air injection method, and is controlled to be 270-295 ℃; the injection speed is high, premature solidification can be prevented during injection, but the material is fragile due to high shearing rate at high speed, so that the injection is controlled to be finished within 4 s; back pressure: generally not exceeding 100bar, is effective in preventing abrasion.
It should be noted that too long a residence time is not used to prevent the molecular weight from decreasing, and temperatures above 300 ℃ are avoided as much as possible; if the machine is stopped for less than 15 minutes, only the idle injection treatment is needed, and if the machine is stopped for more than 15 minutes, the machine is cleaned by using the viscosity PE, and the temperature of the machine barrel is reduced to the temperature of the PE until the machine is started again.
Example five:
the invention also provides a production process of the vacuum sterile blood erythrocyte sedimentation tube, which comprises the following steps:
1) Preparing materials: adding the master batch into the PET base material in a proportion of 1-10% by adopting a special production technology of PET polyester base material and master batch with the viscosity range of 0.5-0.7dl/g, controlling the shear viscosity to be less than or equal to 75Pa.S and the oxygen transmission rate to be less than or equal to 3.0cc (m 2 day) under the conditions of 275 ℃ and the shear rate of 1200S < -1 >, and uniformly mixing the master batch and the base material to obtain a mixture;
2) Drying and crystallizing: putting the mixture obtained in the step 1) into a drying box, heating for 5 hours at 170 ℃, sampling, detecting whether the mixture is completely crystallized by using a light transmission device, starting the stirring function of the drying box when a tiny uncrystallized part exists in the mixture, stirring for 20 minutes, and then drying again, wherein the drying temperature is 170 ℃ and the drying time is 1.5 hours, so as to obtain a crystalline material;
3) And (3) dehumidification: transferring the crystallized material in the step 2) into a dehumidifier, and controlling the rotating speed at 300r/min and the dehumidifying time at 30min;
4) Air exhaust: starting an exhaust fan, controlling the rotating speed to be 800r/min, and removing the micro-dust in the crystallization material, wherein the exhaust time is 10min;
5) Injection molding: selecting a large power system and a PET special screw multi-section temperature control injection molding machine, and carrying out multi-temperature section temperature control; the normal temperature water temperature of the front mold of the mold is 25 ℃, and the cold water temperature of the rear mold is 15 ℃; heating temperature: controlling the temperature of the first section to be 285 ℃, the temperature of the second section to be 275 ℃, the temperature of the third section to be 270 ℃, the temperature of the fourth section to be 270 ℃ and the temperature of the fifth section to be 270 ℃, jetting the molten liquid into a mould at high speed through a nozzle under high pressure, then rapidly cooling the mould by using cooling water, and opening the mould to obtain a high-transparency finished product of the vacuum blood sedimentation tube.
The injection molding process comprises the following steps: because the PET has short stabilization time after melting point and higher melting point, an injection system with more temperature control sections and less self-friction heat generation during plasticizing needs to be selected, and the actual weight of a product (water-containing oral material) cannot be less than 2/3 of the injection amount of a machine; the melt adhesive temperature can be measured by adopting an air injection method, and is controlled to be 270-295 ℃; the injection speed is high, premature solidification can be prevented during injection, but the material is fragile due to high shearing rate at high speed, so that the injection is controlled to be finished within 4 s; back pressure: generally not exceeding 100bar, is effective in preventing abrasion.
It should be noted that too long a residence time is not used to prevent the molecular weight from decreasing, and temperatures above 300 ℃ are avoided as much as possible; if the machine is stopped for less than 15 minutes, only the idle injection treatment is needed, and if the machine is stopped for more than 15 minutes, the viscous PE is used for cleaning, and the temperature of the machine barrel is reduced to the PE temperature until the machine is started again.
The invention also provides a manufacturing method of the vacuum sterile blood erythrocyte sedimentation tube mould, as shown in figure 3, the mould comprises a front mould insert 2, a front mould insert core 3, a push plate insert sleeve 4 and a rear mould insert core 5.
The mould manufacturing comprises seven systems which are respectively as follows: the device comprises a pouring system, a cooling system, an ejection system, a guide system, a forming system, a positioning system and a supporting system;
the mold adopts a needle valve type hot runner middle-lower section one-point side glue feeding mode, and the heating mode adopts a heater, a temperature sensing line and a hot nozzle body which are integrally designed, so that the temperature control is more accurate; a copper pipe heater is used, so that the temperature control is more balanced; the built-in PID function of special temperature control box is adopted, high-precision temperature control is realized under complex conditions and environment, independent temperature control is set, and the tolerance range of precise temperature control is within 0.01 ℃, so that the flow stability of PET after plasticization is ensured, and the defects of yellowing flow marks and the like of test tubes are effectively reduced.
Furthermore, in this embodiment, the mold is selected from two-plate mold, three-plate mold, and hot runner, and the glue feeding mode may also be a 1-10 point side glue feeding mode.
A fountain type cooling system is adopted as a mould cooling mode, and cooling water of the rear mould insert core 5 is cooled by a water cooler and then is sent into the mould through a water pipe; the cooling system adopts a curved water path cooling mode, and the cooling water channels feed water from the middle and discharge water from the periphery, and then return to the water cooler, so that the aims of quickly shaping the product and shortening the production period are fulfilled.
Adopt curve water route refrigerated mode in this embodiment, not only the mould cooling is even, because whole water route cooling of carrying on simultaneously, whole complete cooling moreover, the cooling effect is good, can extension equipment life.
The test tube ejection system adopts an outer periphery push plate ejection system, and multi-section positioning is adopted in the ejection process, so that ejection is more stable, and demolding damage is avoided; simultaneously when adopting two plate mould or three plate mould, ejection system still is provided with the material handle, and the material is furnished with the bullet piece moreover, and the die sinking material is popped out the dropout simultaneously, shortens the cycle and avoids the material to cause the mould crowded to hinder in being detained in the mould simultaneously.
Furthermore, the pouring system is provided with a runner port and an exhaust port, and aiming at the problem that the rear mold core is easy to deflect under the injection pressure, the optimal positioning distance of the embedded core is obtained through repeated demonstration of an experimental mold, so that the embedded core is not easy to deflect, and the rear mold is not too thick and heavy; in the repeated exhaust problem in the injection process, splicing exhaust is performed on the top surface which is easy to trap air through repeated experimental demonstration and theoretical CAE (computer aided engineering) modular flow analysis, and the quantity and the position of the splicing exhaust can be set as required; meanwhile, the exhaust in the process is optimized, and the exhaust steel is used at the position where air trapping is easy to occur, so that the smooth exhaust in the whole injection process is ensured.
In the description of the present invention, it is to be understood that the orientations or positional relationships indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like are based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and for simplicity of description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (6)
1. The manufacturing method of the vacuum sterile blood erythrocyte sedimentation tube mould comprises the steps that the vacuum sterile blood erythrocyte sedimentation tube is provided with a tube body, the upper end of the tube body is connected with a safety protection cap, the cross section of the tube body is of a cylindrical structure, scales are arranged on the outer circumference of the tube body, and a liquid level indication mark is arranged on the tube body; the length of the pipe body is not less than 100mm, and the perpendicularity between the pipe wall of the pipe body and the pipe orifice of the pipe body is less than or equal to 0.2mm;
the die is characterized by comprising a front die insert, a front die insert core, a push plate insert sleeve and a rear die insert core, wherein the die comprises seven systems which are respectively: the device comprises a pouring system, a cooling system, an ejection system, a guide system, a forming system, a positioning system and a supporting system; the mould adopts a needle valve type multi-point side glue feeding mode, the point position glue feeding is 1-10 points, the heating mode adopts a heater, a temperature sensing line and a heat nozzle body which are integrally designed, a copper pipe heater is used, and a special temperature control box is adopted to embed a PID function; the cooling system adopts a fountain type cooling system, and cooling water of the rear die insert core is cooled by a water cooler and then is delivered into the die through a water pipe.
2. The method for manufacturing a vacuum sterile blood erythrocyte sedimentation tube mold according to claim 1, wherein the tube body is made of PET.
3. The method for manufacturing a vacuum sterile blood erythrocyte sedimentation tube mold according to claim 1, wherein the mold is selected from one of a two-plate mold, a three-plate mold and a hot runner, and the glue feeding mode adopts a middle-lower section one-point side glue feeding mode.
4. The method for manufacturing the vacuum sterile blood erythrocyte sedimentation tube mold according to claim 3, wherein a curved water path cooling mode is adopted in the cooling system, and the cooling water paths are water inlet from the middle, water outlet from the periphery and then return to a water cooler.
5. The method of claim 4, wherein the ejection system is an outer circumferential push plate ejection system, the ejection system is multi-stage positioning, the ejection system is provided with a material handle, and the material handle is provided with a spring block.
6. The method for manufacturing the vacuum sterile blood erythrocyte sedimentation tube mold according to claim 5, wherein the casting system adopts exhaust steel, the exhaust steel is used for exhausting, and splicing exhaust is performed on an easily-trapped gas top surface of the mold.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106003540A (en) * | 2016-06-02 | 2016-10-12 | 威海赛威医疗科技有限公司 | Processing technique of medical disposable sodium citrate vacuum blood sampling tube |
| CN207855702U (en) * | 2017-03-06 | 2018-09-14 | 湖北伽诺美生物科技有限公司 | A kind of convenient disposal vacuum heparin tube of sampling |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106003540A (en) * | 2016-06-02 | 2016-10-12 | 威海赛威医疗科技有限公司 | Processing technique of medical disposable sodium citrate vacuum blood sampling tube |
| CN207855702U (en) * | 2017-03-06 | 2018-09-14 | 湖北伽诺美生物科技有限公司 | A kind of convenient disposal vacuum heparin tube of sampling |
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Denomination of invention: The manufacturing method of vacuum sterile red blood cell sedimentation tube mold Effective date of registration: 20230712 Granted publication date: 20230117 Pledgee: Weihai Commercial Bank Co.,Ltd. Lingang Economic and Technological Development Zone sub branch Pledgor: WEIHAI SAIWEI MEDICAL TECHNOLOGY CO.,LTD. Registration number: Y2023110000286 |