CN114129653A - Composition for relieving bone joint pain and preparation method thereof - Google Patents
Composition for relieving bone joint pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition for relieving bone joint pain and a preparation method thereof, the composition comprises emu oil, garlic oil, notoginsenoside R1 and aucubin, and the peroxide value of the emu oil is lower than 1 meq/kg. The preparation method comprises the following steps: mixing emu oil, oleum Bulbus Allii, notoginsenoside R1, aucubin, vitamin E and vitamin B6, and stirring. The medicine can enhance the medicine-loading rate and improve the treatment effect by utilizing the permeability of emu oil and garlic oil, has the effects of taking effect quickly and effectively relieving bone joint pain by the synergistic action of the four active components, can activate the functions of a human body by compounding vitamin E and vitamin B6, and can further enhance the treatment effect by matching with emu oil, garlic oil, notoginsenoside R1 and aucubin. Meanwhile, the invention has the advantages of definite functional components, good safety and low toxic and side effects, and can be used for a long time.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a composition for relieving bone and joint pain and a preparation method thereof.
Background
Osteoarticular pain is a common disease and frequently encountered disease of the old, and is characterized by long pain course and serious pain degree. In clinic, a plurality of patients have serious influence on the quality of life because the pain is not effectively controlled and the pain medicament is not treated in a standard way. Clinically, short-term treatment is often performed in a week-based time frame in chronic pain patients, and long-term treatment effects of opioid drugs in a month-based time frame are not clear. Long-term pain treatment tests often worry about the safety and tolerance of opioid drugs, and neglect the long-term efficacy.
CN106619877A discloses a composition for improving osteoarticular pain, which is composed of the following components in parts by weight: the health-care food comprises, by weight, 15-20 parts of dogwood extract, 10-15 parts of oyster extract, 10-15 parts of astragalus extract, 10-15 parts of poria cocos extract, 3-5 parts of hawthorn extract, 3-5 parts of glucosamine, 25-35 parts of water-soluble dietary fiber and 6-8 parts of sweetener.
CN102210845A discloses a traditional Chinese medicine for treating bone and joint pain, (1) musk is taken and ground into fine powder for standby; (2) pulverizing cortex Cinnamomi and radix Angelicae sinensis into fine powder; (3) pulverizing angelica sinensis, radix rehmanniae preparata, semen brassicae, radix scrophulariae, honeysuckle, platycladi seed, baked ginger, safflower, ephedra, frankincense, liquorice and myrrh into coarse powder, adding water for decoction, filtering decoction dregs, concentrating the decoction liquid to the relative density of 1.2-1.4, adding melted antler glue while the decoction liquid is hot, adding starch, drying the decoction liquid, and pulverizing residues into fine powder for later use; (4) mixing the fine powders obtained in the steps (1), (2) and (3), and making into medical capsule. The invention has obvious treatment effect, is effective to various bone and joint pains, relieves the pain of patients and has lower use cost.
The existing medicines for treating or relieving joint pain have limited effect, generally need to be matched with other pain-relieving medicines for use, and generally have the problems of long treatment period, slow effect and the like.
Emu oil (Emu oil) is an oil substance extracted from the subcutaneous and retroperitoneal adipose tissues of Emu, and is known as "vital oil" in australia, europe, the united states, and the like. Emu oil (Emu oil) is considered to be the most valuable component of Emu bodies because it contains high levels of nutrients such as unsaturated fatty acids, proteins, and iron, and low levels of cholesterol. Native australian clans are accustomed to the use of emu oil for external treatment of skin disorders, muscle aches, arthritis, abrasions, burns, sunburn and the like. Research shows that emu oil can be used for treating mucositis, enteritis, colon cancer, auricular inflammation, osteoporosis caused by chemotherapy, etc. after being taken orally. Therefore, it has attracted a high degree of attention in the medical and nutritional fields.
Through retrieval, the emu oil is relatively rarely scientifically researched for relieving the bone joint pain, so that the development of the composition for relieving the bone joint pain with quick response and good treatment effect and the preparation method thereof have important significance.
Disclosure of Invention
The composition has good permeability and quick response, can effectively relieve the arthralgia, is safe, has no toxic or side effect, and can be used for a long time.
In order to achieve the purpose, the invention adopts the following technical scheme:
a composition for relieving bone and joint pain comprises emu oil, garlic oil, notoginsenoside R1 and aucubin, wherein the emu oil has a peroxide value of less than 1 meq/kg.
Preferably, the emu oil is used in an amount of any integer or decimal from 3 to 9 parts by weight, such as 3 parts by weight, 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 3.1 parts by weight, 4.1 parts by weight, 5.1 parts by weight, 6.1 parts by weight, 7.1 parts by weight, 8.1 parts by weight … … 3.9.9 parts by weight, 4.9 parts by weight, 5.9 parts by weight, 6.9 parts by weight, 7.9 parts by weight, 8.9 parts by weight.
Preferably, the garlic oil is used in an amount of any one of 4 to 12 parts by weight, such as 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 4.1 parts by weight, 5.1 parts by weight, 6.1 parts by weight, 7.1 parts by weight, 8.1 parts by weight, 9.1 parts by weight, 10.1 parts by weight, 11.1 parts by weight, 12 parts by weight, … … 4.9.9 parts by weight, 5.9 parts by weight, 6.9 parts by weight, 7.9 parts by weight, 8.9 parts by weight, 9.9 parts by weight, 10.9 parts by weight, 11.9 parts by weight.
Preferably, the notoginsenoside R1 is used in an amount of 5 to 12 parts by weight, such as 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 5.1 parts by weight, 6.1 parts by weight, 7.1 parts by weight, 8.1 parts by weight, 9.1 parts by weight, 10.1 parts by weight, 11.1 parts by weight, 12 parts by weight, … … 5.9.9 parts by weight, 6.9 parts by weight, 7.9 parts by weight, 8.9 parts by weight, 9.9 parts by weight, 10.9 parts by weight, 11.9 parts by weight.
Preferably, the aucubin is used in an amount of any one of integers or fractions from 8 to 16 parts by weight, such as8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 8.1 parts by weight, 9.1 parts by weight, 10.1 parts by weight, 11.1 parts by weight, 12.1 parts by weight, 13.1 parts by weight, 14.1 parts by weight, 15.1 parts by weight, … … 8.9.9 parts by weight, 9.9 parts by weight, 10.9 parts by weight, 11.9 parts by weight, 12.9 parts by weight, 13.9 parts by weight, 14.9 parts by weight, 15.9 parts by weight.
The technical effects of the invention can be realized by the technical schemes, but better technical effects can be achieved by other preferable technical schemes.
Preferably, the composition further comprises vitamin E and vitamin B6.
More preferably, the composition comprises, by weight, 4-8 parts of emu oil, 5-11 parts of garlic oil, 6-11 parts of notoginsenoside R, 9-15 parts of aucubin, 0.02-0.05 part of vitamin E and 60.01-0.03 part of vitamin B.
Still more preferably, the composition comprises, by weight, 5-7 parts of emu oil, 6-10 parts of garlic oil, 7-10 parts of notoginsenoside R, 10-14 parts of aucubin, 0.025-0.045 part of vitamin E and 0.025 part of vitamin B60.015.
Most preferably, the composition comprises, by weight, 6 parts of emu oil, 8 parts of garlic oil, 8 parts of notoginsenoside R, 12 parts of aucubin, 0.035 parts of vitamin E and 60.02 parts of vitamin B.
The invention also provides a preparation method of the composition for relieving bone joint pain, which comprises the following steps: mixing emu oil, garlic oil, notoginsenoside R1, aucubin, vitamin E and vitamin B6, and stirring to obtain the composition.
The invention also provides application of the composition for relieving bone joint pain in preparation of a medicine for relieving bone joint pain.
Preferably, the medicament is an external preparation or an oral preparation.
Further preferably, the external agent includes, but is not limited to, liniments and ointments; such oral formulations include, but are not limited to, soft gelatin capsules and pills.
An external ointment for relieving bone joint pain comprises the composition for relieving bone joint pain and medically acceptable auxiliary materials.
A soft capsule for relieving bone joint pain comprises the composition for relieving bone joint pain and medically acceptable auxiliary materials.
The invention has the beneficial effects that:
(1) according to the composition for relieving bone joint pain, emu oil, garlic oil, notoginsenoside R1 and aucubin are selected as raw materials, wherein the notoginsenoside R1 and the aucubin can dredge collaterals and activate collaterals, dissipate blood stasis and relieve pain, the emu oil has good effects of resisting inflammation and enhancing drug permeability, and the garlic oil can promote blood circulation. The permeability of emu oil and garlic oil can be utilized to enhance drug-loading rate and improve treatment effect, and the four active components have the effects of taking effect quickly and effectively relieving bone joint pain through the synergistic effect among the components.
(2) The invention also comprises vitamin E and vitamin B6 which can activate human body function, and can enhance the treatment effect when being matched with emu oil, garlic oil, notoginsenoside R1 and aucubin.
(3) The emu oil has the characteristics of balanced pH value similar to human skin, is easy to be absorbed by the skin after being used by utilizing the compound use of the emu oil, the garlic oil, the notoginsenoside R1 and the aucubin, has the effect of protecting the skin, and avoids the skin from being damaged by long-term use of external medicaments. Thus, it can be used for a long period of time.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The sources of the raw materials used in the present invention are not limited, and the raw materials used in the present invention are all those commonly available in the art unless otherwise specified.
Emu oil: purchased from emu industries, Inc., New York, Guangdong, said emu oil having a peroxide value of less than 1 meq/kg.
Garlic oil: purchased from xinda natural perfumery, jishui county, cat #: CAS 8000-78-0.
Notoginsenoside R1, available from kywmaste biotechnology limited, cat #: 80418-24-2.
Aucubin: purchased from Shanghai Huo pharmaceutical science and technology development Limited, Cathaya entry: 479-98-1.
A composition for relieving bone and joint pain comprises emu oil, garlic oil, notoginsenoside R1 and aucubin, wherein the emu oil has a peroxide value of less than 1 meq/kg.
Preferably, the emu oil is used in an amount of any integer or decimal from 3 to 9 parts by weight, such as 3 parts by weight, 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 3.1 parts by weight, 4.1 parts by weight, 5.1 parts by weight, 6.1 parts by weight, 7.1 parts by weight, 8.1 parts by weight … … 3.9.9 parts by weight, 4.9 parts by weight, 5.9 parts by weight, 6.9 parts by weight, 7.9 parts by weight, 8.9 parts by weight.
Preferably, the garlic oil is used in an amount of any one of 4 to 12 parts by weight, such as 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 4.1 parts by weight, 5.1 parts by weight, 6.1 parts by weight, 7.1 parts by weight, 8.1 parts by weight, 9.1 parts by weight, 10.1 parts by weight, 11.1 parts by weight, 12 parts by weight, … … 4.9.9 parts by weight, 5.9 parts by weight, 6.9 parts by weight, 7.9 parts by weight, 8.9 parts by weight, 9.9 parts by weight, 10.9 parts by weight, 11.9 parts by weight.
Preferably, the notoginsenoside R1 is used in an amount of 5 to 12 parts by weight, such as 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 5.1 parts by weight, 6.1 parts by weight, 7.1 parts by weight, 8.1 parts by weight, 9.1 parts by weight, 10.1 parts by weight, 11.1 parts by weight, 12 parts by weight, … … 5.9.9 parts by weight, 6.9 parts by weight, 7.9 parts by weight, 8.9 parts by weight, 9.9 parts by weight, 10.9 parts by weight, 11.9 parts by weight.
Preferably, the aucubin is used in an amount of any one of integers or fractions from 8 to 16 parts by weight, such as8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 8.1 parts by weight, 9.1 parts by weight, 10.1 parts by weight, 11.1 parts by weight, 12.1 parts by weight, 13.1 parts by weight, 14.1 parts by weight, 15.1 parts by weight, … … 8.9.9 parts by weight, 9.9 parts by weight, 10.9 parts by weight, 11.9 parts by weight, 12.9 parts by weight, 13.9 parts by weight, 14.9 parts by weight, 15.9 parts by weight.
The technical effects of the invention can be realized by the technical schemes, but better technical effects can be achieved by other preferable technical schemes.
Preferably, the composition further comprises vitamin E and vitamin B6.
More preferably, the composition comprises, by weight, 4-8 parts of emu oil, 5-11 parts of garlic oil, 6-11 parts of notoginsenoside R, 9-15 parts of aucubin, 0.02-0.05 part of vitamin E and 60.01-0.03 part of vitamin B.
Still more preferably, the composition comprises, by weight, 5-7 parts of emu oil, 6-10 parts of garlic oil, 7-10 parts of notoginsenoside R, 10-14 parts of aucubin, 0.025-0.045 part of vitamin E and 0.025 part of vitamin B60.015.
Most preferably, the composition comprises, by weight, 6 parts of emu oil, 8 parts of garlic oil, 8 parts of notoginsenoside R, 12 parts of aucubin, 0.035 parts of vitamin E and 60.02 parts of vitamin B.
The invention also provides a preparation method of the composition for relieving bone joint pain, which comprises the following steps: mixing emu oil, garlic oil, notoginsenoside R1, aucubin, vitamin E and vitamin B6, and stirring to obtain the composition.
Examples 1 to 7A composition for relieving osteoarticular pain and a method for preparing the same
The components and amounts of the compositions of examples 1-7 are shown in Table 1, where "-" indicates no additions.
TABLE 1 Components and amounts (weight method) of the compositions described in examples 1-7
The preparation method comprises the following steps: mixing emu oil, garlic oil, notoginsenoside R1, aucubin, vitamin E and vitamin B6, and stirring to obtain the composition.
Comparative example 1
The present comparative example differs from example 7 in that tripterine is used instead of notoginsenoside R1.
Comparative example 2
The present comparative example differs from example 7 in that notoginsenoside R1 was 3 parts and aucubin 18 parts.
Comparative example 3
The present comparative example differs from example 7 in that notoginsenoside R1 was 15 parts and aucubin was 6 parts.
Evaluation of Effect of relieving arthralgia
1. Laboratory animal
SD rats, 120, half male and female, 8 weeks old.
2. Pharmaceutical preparation
According to the mass ratio of 1: 1, the compositions prepared in examples 1 to 7 and comparative examples 1 to 3 were mixed with tea oil and stirred uniformly to obtain drugs 1 to 10, respectively.
3. Molding method
The volume ratio is 1: 1.1 papain 4% and 0.02moL/L L-cysteine were injected into knee joint cavities to construct a knee-bone joint model.
4. Experimental methods
The SD rats are randomly divided into a blank control group and a model group, the SD rats after model building of the model group are randomly divided into the model control group and a drug group according to sex, the drug group is coated with 1-10 prepared drugs at 8 o' clock each day, the coating dosage is 2ml, and the drugs are continuously administered for 10 weeks. Equal volume of tea oil was applied to the blank control group and the model group.
The levels of inflammatory factors IL-1 beta, IL-6, TNF-alpha in the synovium were measured by ELIASE method.
5. Results of the experiment
TABLE 2 content of inflammatory factors IL-1 beta, IL-6, TNF-alpha in synovial membrane of knee osteoarthritis
From the above, the composition for relieving bone joint pain of the invention can inhibit the expression of IL-1 beta, IL-6 and TNF-alpha, and has the technical effect of relieving knee osteoarthritis pain, and meanwhile, according to the pharmaceutical groups 8-10, when the pseudo-ginseng saponin R1 in the composition is changed into tripterine or the dosage of pseudo-ginseng saponin R1 and aucubin is out of the range required by the invention, the prepared composition does not have the technical effect of relieving bone joint pain.
Based on the composition for relieving the bone joint pain and the effect of relieving the bone joint pain, the invention also provides application of the composition for relieving the bone joint pain in preparing a medicine for treating and relieving the bone joint pain.
Specifically, the medicine is an external preparation or an oral preparation.
Wherein, the external agent includes but is not limited to liniment and ointment; such oral formulations include, but are not limited to, soft gelatin capsules and pills.
The invention also provides a medicine for relieving bone joint pain, which comprises but is not limited to the following two medicines:
an external ointment for relieving bone joint pain comprises the composition for relieving bone joint pain and medically acceptable auxiliary materials; the composition for relieving bone joint pain used in the external ointment is preferably the formula which does not contain vitamin E and vitamin B6.
The soft capsule for relieving the bone joint pain comprises the composition for relieving the bone joint pain and medically acceptable auxiliary materials, and the composition for relieving the bone joint pain adopted in the soft capsule is preferably the formula comprising vitamin E and vitamin B6.
In conclusion, the composition for relieving bone joint pain disclosed by the invention is prepared by selecting emu oil, garlic oil, notoginsenoside R1 and aucubin as raw materials, wherein the notoginsenoside R1 and aucubin can dredge vessels and activate collaterals, remove stasis and relieve pain, the emu oil has good effects of resisting inflammation and enhancing drug permeability, and the garlic oil can promote blood circulation. The permeability of emu oil and garlic oil can be utilized to enhance drug-loading rate and improve treatment effect, and the four active components have the effects of taking effect quickly and effectively relieving bone joint pain through the synergistic effect among the components.
The invention also comprises vitamin E and vitamin B6 which can activate human body function, and can enhance the treatment effect when being matched with emu oil, garlic oil, notoginsenoside R1 and aucubin.
The emu oil has the characteristics of balanced pH value similar to human skin, is easy to be absorbed by the skin after being used by utilizing the compound use of the emu oil, the garlic oil, the notoginsenoside R1 and the aucubin, has the effect of protecting the skin, and avoids the skin from being damaged by long-term use of external medicaments. Thus, it can be used for a long period of time.
The present invention has been further described with reference to specific embodiments, which are only exemplary and do not limit the scope of the present invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (10)
1. A composition for relieving bone and joint pain, comprising emu oil, garlic oil, notoginsenoside R1 and aucubin, wherein said emu oil has a peroxide value of less than 1 meq/kg.
2. A composition according to claim 1, comprising, by weight, 3 to 9 parts of emu oil, 4 to 12 parts of garlic oil, 8 to 16 parts of aucubin and 15 to 12 parts of notoginsenoside.
3. The composition of claim 2, further comprising vitamin E and vitamin B6.
4. A composition according to claim 3, comprising, by weight, 4-8 parts emu oil, 5-11 parts garlic oil, 6-11 parts notoginsenoside R, 9-15 parts aucubin, 0.02-0.05 part vitamin E and 60.01-0.03 part vitamin B.
5. A composition according to claim 3, comprising, by weight, 5-7 parts emu oil, 6-10 parts garlic oil, 7-10 parts notoginsenoside R, 10-14 parts aucubin, 0.025-0.045 parts vitamin E and 0. 60.015-0.025 parts vitamin B.
6. The method for preparing a composition for relieving osteoarticular pain according to any one of claims 1 to 5, wherein the method comprises the steps of: mixing emu oil, garlic oil, notoginsenoside R1, aucubin, vitamin E and vitamin B6, and stirring to obtain the composition.
7. Use of the composition for relieving osteoarticular pain according to any one of claims 1 to 5 in the preparation of a medicament for relieving osteoarticular pain.
8. The use of claim 7, wherein the medicament is a topical or oral formulation.
9. An external ointment for relieving bone joint pain comprises the composition for relieving bone joint pain and medically acceptable auxiliary materials.
10. A soft capsule for relieving bone joint pain comprises the composition for relieving bone joint pain and medically acceptable auxiliary materials.
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| CN2021115822333 | 2021-12-22 | ||
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| CN108472328A (en) * | 2016-01-08 | 2018-08-31 | 英创康集团有限公司 | Garlic composition |
| CN108992455A (en) * | 2018-07-13 | 2018-12-14 | 大连理工大学 | A kind of aucubin inhibits the application of inflammatory factor release |
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| CN108472328A (en) * | 2016-01-08 | 2018-08-31 | 英创康集团有限公司 | Garlic composition |
| CN108992455A (en) * | 2018-07-13 | 2018-12-14 | 大连理工大学 | A kind of aucubin inhibits the application of inflammatory factor release |
| CN109381353A (en) * | 2018-11-26 | 2019-02-26 | 深圳市景光生物科技有限公司 | A kind of cream reaching repairing effect of releiving with fat of Oromaius norvaehollandeae |
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