CN114129627A - Composition ointment for treating psoriasis, medical cap product and application of composition ointment - Google Patents
Composition ointment for treating psoriasis, medical cap product and application of composition ointment Download PDFInfo
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- CN114129627A CN114129627A CN202110835724.8A CN202110835724A CN114129627A CN 114129627 A CN114129627 A CN 114129627A CN 202110835724 A CN202110835724 A CN 202110835724A CN 114129627 A CN114129627 A CN 114129627A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A42—HEADWEAR
- A42B—HATS; HEAD COVERINGS
- A42B1/00—Hats; Caps; Hoods
- A42B1/017—Hats; Caps; Hoods specially adapted for promoting health, e.g. with means for pressing on acupuncture points
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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Abstract
The invention discloses a composition ointment for treating psoriasis, a medical cap product and application thereof. The invention adopts two natural traditional Chinese medicine raw materials of angelica and sanguisorba, the angelica is warm in nature, the sanguisorba is cold in nature, and the ointment preparation with the functions of clearing heat and removing toxicity, cooling blood and healing sore is combined through technical measures such as compatibility, preparation processing and the like, has the effects of moistening, moisturizing and astringing skin, wraps an affected part by using a moist bandage in the treatment process, fully fuses the ointment and a wound surface, ensures the sealing of the ointment on the wound surface, has the function of resisting infection, avoids the wound surface from being exposed in the air to cause external toxin to infect the wound surface, and is beneficial to the repair and regeneration of wound surface tissues.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a composition ointment for treating psoriasis, a medical cap product and application thereof.
Background
Psoriasis, a chronic relapsing inflammatory skin disease characterized primarily by erythematous papules and squamous lesions. It is generally classified into localized psoriasis and generalized psoriasis according to the size of skin lesions. The localized psoriasis is classified into scalp psoriasis, facial psoriasis, nail psoriasis, palmoplantar psoriasis, mucous membrane psoriasis, reverse psoriasis, etc. according to the affected part. The cause of psoriasis is unknown, the psoriasis is stubborn and difficult to treat, the psoriasis is easy to attack repeatedly, the psoriasis brings serious influence to the normal work and life of a patient, and the psoriasis devastates the self-respect and confidence of the patient. The method for treating psoriasis by traditional Chinese medicines is long-standing, but most of the existing traditional Chinese medicine external medicine treatment schemes are to apply the traditional Chinese medicine composition on the affected part and then wrap the affected part by dry gauze, so that the problems of unobvious treatment effect and inconvenient use exist.
Disclosure of Invention
The invention aims to provide a composition ointment for treating psoriasis, a medical cap product and application thereof, and aims to solve the technical problems.
In order to achieve the purpose, the technical scheme of the invention is as follows:
according to the first aspect, the invention provides a composition ointment for treating psoriasis, which is characterized by comprising the following raw materials in percentage by weight: 0.1-5 parts of angelica, 0.1-5 parts of garden burnet, 5-15 parts of vaseline, 0.1-2 parts of lanolin and 0.1-2 parts of glycerol.
Preferably, the composition ointment comprises the following raw materials in parts by weight: 1-2 parts of angelica, 1-2 parts of garden burnet, 6-10 parts of vaseline, 0.3-0.7 part of lanolin and 0.3-0.7 part of glycerol.
Further preferably, the composition ointment comprises the following raw materials in parts by weight: 1.5 parts of angelica, 1.5 parts of garden burnet, 9 parts of vaseline, 0.5 part of lanolin and 0.5 part of glycerol.
Preferably, the composition ointment is prepared by adopting the following method:
heating vaseline to melt to obtain melt, adding radix Angelicae sinensis and radix Sangusorbae, heating and stirring to scorch, taking out, filtering, cooling, adding lanolin and glycerol, stirring, and packaging to obtain the final product.
Further preferably, the melting temperature is 60-80 ℃.
In a second aspect, the invention provides a medical headwear product, which comprises a headwear and an ointment layer attached to the inner side of the headwear, wherein the ointment layer is formed by coating the composition for treating psoriasis according to the first aspect.
Preferably, the cap comprises an inner cap body and an outer cap body, and the inner cap body is arranged in the outer cap body.
Further preferably, the cap body is cut and sewn by a bandage.
In a third aspect, the invention provides the use of a composition ointment as described in the first aspect for the treatment of psoriasis in the manufacture of a combination medicament for the treatment of psoriasis.
Preferably, the skin disease comprises one or more of scalp psoriasis, facial psoriasis, nail psoriasis, palmoplantar psoriasis, and mucous membrane psoriasis.
Preferably, the combination medicine for treating psoriasis comprises the composition ointment for treating psoriasis and also comprises one or more of halcinonide liniment, daruss liniment and semel gel.
Compared with the prior art, the invention has the beneficial effects that:
the invention adopts two natural traditional Chinese medicine raw materials of angelica and sanguisorba, the angelica is warm in nature, the sanguisorba is cold in nature, and the ointment preparation with the functions of clearing heat and removing toxicity, cooling blood and healing sore is combined through technical measures such as compatibility, preparation processing and the like, has the effects of moistening, moisturizing and astringing skin, wraps an affected part by using a moist bandage in the treatment process, fully fuses the ointment and a wound surface, ensures the sealing of the ointment on the wound surface, has the function of resisting infection, avoids the wound surface from being exposed in the air to cause external toxin to infect the wound surface, and is beneficial to the repair and regeneration of wound surface tissues. The medical cap product provided by the invention is suitable for large-area dry, severe skin damage and severe itching skin, repairs skin barriers, blocks the vicious circle of pruritus-scratching-pruritus, is comfortable in skin feeling and breathable, and does not influence the normal activities of patients.
Drawings
FIG. 1 is a comparison of a patient's forehead position before and after psoriasis treatment provided by the present invention;
FIG. 2 is a comparison of the hindbrain and nape position of a patient before and after psoriasis treatment provided by the present invention.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
Respectively crushing the angelica and the garden burnet into powder with the particle size of 5-10 mu m by adopting an ultrafine crusher, and weighing the following raw materials: 1500g of angelica sinensis, 1500g of sanguisorba officinalis, 9000g of vaseline, 500g of lanolin and 500g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, adding the angelica sinensis and the sanguisorba officinalis, heating and stirring until the mixture is scorched, taking out the mixture, filtering the mixture by using four layers of gauze, cooling, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Randomly selecting 25 patients with psoriasis clinically diagnosed, wherein the age is 29-58 years, the course of the disease is 1-5 years, the patients have no significant difference in the area and severity of skin lesions, randomly dividing the patients into 3 groups, respectively externally coating halcinonide liniment, daruss liniment and semel gel on each group, then respectively externally coating the ointment of the embodiment 1 for package treatment, applying the ointment to the affected skin once a day, treating the affected skin for 5 times according to the skin treatment condition, and stopping taking the medicine if the patients are cured within five times.
The overall treatment effect of the scalp psoriasis is evaluated for each group according to the recent treatment effect implementation standard (1987) of the national psoriasis scientific research cooperative group. Evaluation criteria: firstly, healing: the rash subsided by more than 90%; secondly, effect is displayed: fading the rash by 60-90%; ③ effective: fading the rash by 30-60%; fourthly, invalidation: the rash subsided less than 30%.
And (3) displaying a statistical result: 13 cases are cured in the halcinonide group, 10 cases are obviously effective, and 2 cases are effective; 14 cases are cured in the Dalishu group, 10 cases are obviously effective, and 1 case is effective; in the Seimell group, 14 cases were cured, 8 cases were significantly effective, and 3 cases were effective.
FIG. 1 is a comparative graph after applying Dallas liniment and the composition ointment of example 1 twice; as can be seen from fig. 1 and daily observations, the red papules on the forehead of the patient fused to form a large patch, and the red papules of the patient regressed after two applications, with a significant reduction in the area of the red papules and a lightening of the color.
FIG. 2 is a comparative graph showing the application of three applications of the Daltonian liniment and the composition ointment of example 1; as can be seen from FIG. 1 and daily observations, the patient had red pimples with large bean grains in the nape and hindbrain, and the red pimples were rapidly reduced after three applications.
Example 2
Respectively crushing the angelica and the garden burnet by a common crusher, sieving the crushed angelica and the garden burnet by a sieve of 100 meshes to obtain powder, then heating the vaseline to melt at 60-80 ℃ to obtain a melt, adding the angelica and the garden burnet, heating and stirring the mixture to be scorched, fishing out the mixture, filtering the mixture by four layers of gauze, cooling the mixture, adding the lanolin and the glycerol, stirring the mixture uniformly, and subpackaging the mixture to obtain a finished product.
Example 3
Respectively crushing the angelica and the garden burnet into powder with the particle size of 5-10 mu m by adopting an ultrafine crusher, and weighing the following raw materials: 2000g of angelica sinensis, 2000g of sanguisorba officinalis, 10000g of vaseline, 700g of lanolin and 700g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, adding the angelica sinensis and the sanguisorba officinalis, heating and stirring until the mixture is scorched, taking out the mixture, filtering the mixture by using four layers of gauze, cooling the mixture, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Example 4
Respectively crushing the angelica and the garden burnet into powder with the particle size of 5-10 mu m by adopting an ultrafine crusher, and weighing the following raw materials: 1200g of angelica sinensis, 1600g of sanguisorba officinalis, 8000g of vaseline, 400g of lanolin and 600g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a melt, adding the angelica sinensis and the sanguisorba officinalis, heating and stirring until the mixture is scorched, taking out the mixture, filtering the mixture by using four layers of gauze, cooling the mixture, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Example 5
Respectively crushing the angelica and the garden burnet into powder with the particle size of 5-10 mu m by adopting an ultrafine crusher, and weighing the following raw materials: 100g of angelica sinensis, 100g of sanguisorba officinalis, 5000g of vaseline, 100g of lanolin and 100g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, adding the angelica sinensis and the sanguisorba officinalis, heating and stirring until the mixture is scorched, taking out the mixture, filtering the mixture by using four layers of gauze, cooling the mixture, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Example 6
Respectively crushing the angelica and the garden burnet into powder with the particle size of 5-10 mu m by adopting an ultrafine crusher, and weighing the following raw materials: 5000g of angelica sinensis, 5000g of sanguisorba officinalis, 15000g of vaseline, 2000g of lanolin and 2000g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, adding the angelica sinensis and the sanguisorba officinalis, heating and stirring until the mixture is scorched, taking out the mixture, filtering the mixture by using four layers of gauze, cooling, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Comparative example 1
Smashing the garden burnet into powder with the particle size of 5-10 mu m by using an ultrafine grinder, and weighing the following raw materials: 1500g of garden burnet, 9000g of vaseline, 500g of lanolin and 500g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, adding the garden burnet, heating and stirring to scorch, taking out, filtering with four layers of gauze, cooling, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Comparative example 2
Crushing the angelica into powder with the particle size of 5-10 mu m by using an ultrafine crusher, and weighing the following raw materials: 1500g of angelica sinensis, 9000g of vaseline, 500g of lanolin and 500g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, adding the angelica sinensis, heating and stirring to scorch, taking out, filtering with four layers of gauze, cooling, adding the lanolin and the glycerol, stirring uniformly, and subpackaging to obtain a finished product.
Comparative example 3
Weighing the following raw materials: 9000g of vaseline, 500g of lanolin and 500g of glycerol, heating the vaseline to melt at the temperature of 60-80 ℃ to obtain a molten material, taking out the molten material, filtering the molten material by using four layers of gauze, cooling, adding the lanolin and the glycerol, uniformly stirring, and subpackaging to obtain a finished product.
180 patients diagnosed with psoriasis clinically are randomly selected, the age is 29-58 years, the course of the disease is 1-5 years, the patients have no significant difference in the area and severity of skin lesions, and the patients are randomly divided into nine groups of 20 patients.
The treatment scheme comprises the following steps: the medicine is applied once a day for 5 days. The application method comprises the following steps: after the skin of an affected part of the head is slightly punctured by the microneedle, the daruss and the composition ointment are sequentially smeared on the skin, then the inner-layer cap body is wetted by water at the temperature of 32-37 ℃, is wrung until no water drops, then the wet inner-layer cap body is carried on the head of a patient, then the dry outer-layer cap body is sleeved on the outer-layer cap body to form a double-layer package, the double-layer package is wrapped for 3-24 hours, the outer-layer cap is taken down every 2-3 hours, water is sprayed on the inner-layer cap, and the wet state of the outer-layer cap body is maintained. The scalp is wrapped by the dry and wet cap bodies, so that drug absorption can be promoted, the effect of treating scalp psoriasis is good, and recovery of the patient's condition is facilitated.
The following examples and comparative examples were evaluated for overall treatment of scalp psoriasis according to the recent treatment efficacy performance criteria of the national psoriasis scientific research cooperative group (1987). Evaluation criteria: firstly, healing: the rash subsided by more than 90%; secondly, effect is displayed: fading the rash by 60-90%; ③ effective: fading the rash by 30-60%; fourthly, invalidation: the rash subsided less than 30%.
The statistical results are as follows:
the therapeutic effects of example 1 were: firstly, healing: 9 cases; secondly, effect is displayed: 9 cases; ③ effective: 2, example; fourthly, invalidation: 0.
the therapeutic effects of example 2 were: firstly, healing: 8 cases of the reaction; secondly, effect is displayed: 9 cases; ③ effective: 3 cases; fourthly, invalidation: 0.
the therapeutic effects of example 3 were: firstly, healing: 8 cases of the reaction; secondly, effect is displayed: 7 cases of (1); ③ effective: 5 cases of the above-mentioned reaction; fourthly, invalidation: 0.
the therapeutic effects of example 4 were: firstly, healing: 8 cases of the reaction; secondly, effect is displayed: 9 cases; ③ effective: 3 cases; fourthly, invalidation: 0.
the therapeutic effects of example 5 were: firstly, healing: 5 cases of the above-mentioned reaction; secondly, effect is displayed: 7 cases of (1); ③ effective: 7 cases of (1); fourthly, invalidation: 1.
the therapeutic effects of example 6 were: firstly, healing: 6 cases of the reaction; secondly, effect is displayed: 7 cases of (1); ③ effective: 6 cases of the reaction; fourthly, invalidation: 1.
the therapeutic effect of comparative example 1 was: firstly, healing: 1 example; secondly, effect is displayed: 5 cases of the above-mentioned reaction; ③ effective: 10 cases of the treatment; fourthly, invalidation: 4.
the therapeutic effect of comparative example 2 was: firstly, healing: 1 example; secondly, effect is displayed: 5 cases of the above-mentioned reaction; ③ effective: 12 cases of (1); fourthly, invalidation: 3.
the therapeutic effect of comparative example 3 was: firstly, healing: case 0; secondly, effect is displayed: 4 cases; ③ effective: 13 cases; fourthly, invalidation: 3.
in order to further illustrate the beneficial effects of the invention, the inner cap body and the outer cap body are sewn on the bandage by the prior process, and the ointment provided by the embodiment of the invention can be coated on the inner side of the inner cap body by a coating process, then the medical release paper is covered, and the medical cap product is obtained by sealing and packaging. When the medical cap is used, the package is disassembled, the release paper is taken down, the inner cap body is worn on the head of a patient, water is sprayed to the inner cap body (the temperature of water is 32-37 ℃) to enable the inner cap body to be in a wet state, then the outer cap body is sleeved with the dry outer cap body to form a double-layer package, the outer cap body is taken down after 3-24 hours of package, water is sprayed to the inner cap body every 2-3 hours, and the wet state is maintained. The medical cap product is convenient to use, can be matched with an external hormone ointment for use, promotes drug absorption, quickly takes effect, reduces the using amount of external hormone, is suitable for large-area dry, severe skin damage and severe itching skin, repairs skin barriers, blocks the vicious circle of pruritus, scratching and pruritus, is comfortable in skin feeling, is breathable, and does not influence the normal activities of patients.
The embodiments of the present invention have been described in detail, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (9)
1. The composition ointment for treating psoriasis is characterized by comprising the following raw materials in percentage by weight: 0.1-5 parts of angelica, 0.1-5 parts of garden burnet, 5-15 parts of vaseline, 0.1-2 parts of lanolin and 0.1-2 parts of glycerol.
2. The composition ointment for treating psoriasis according to claim 1, wherein the composition ointment comprises 1 to 2 parts of angelica sinensis, 1 to 2 parts of sanguisorba officinalis, 6 to 10 parts of vaseline, 0.3 to 0.7 part of lanolin and 0.3 to 0.7 part of glycerin.
3. The composition ointment for treating psoriasis according to claim 1, which comprises the following raw materials in parts by weight: 1.5 parts of angelica, 1.5 parts of garden burnet, 9 parts of vaseline, 0.5 part of lanolin and 0.5 part of glycerol.
4. The composition ointment for treating psoriasis according to claim 1, which is prepared by the following method:
heating vaseline to melt to obtain melt, adding radix Angelicae sinensis and radix Sangusorbae, heating and stirring to scorch, taking out, filtering, cooling, adding lanolin and glycerol, stirring, and packaging to obtain the final product.
5. The composition ointment for treating psoriasis according to claim 4, wherein the melting temperature is 60 to 80 ℃.
6. A medical cap product, which is characterized by comprising a cap and an ointment layer attached to the inner side of the cap, wherein the ointment layer is formed by coating the composition ointment for treating psoriasis according to claim 1.
7. The article of medicinal headwear of claim 1, wherein the cap is formed from a bandage.
8. Use of a composition ointment according to claim 1 for the treatment of psoriasis in the manufacture of a combination medicament for the treatment of psoriasis.
9. Use according to claim 8, wherein the skin disorders comprise one or more of scalp psoriasis, facial psoriasis, nail psoriasis, palmoplantar psoriasis, mucosal psoriasis.
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| CN202110835724.8A CN114129627A (en) | 2021-07-23 | 2021-07-23 | Composition ointment for treating psoriasis, medical cap product and application of composition ointment |
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| CN202110835724.8A CN114129627A (en) | 2021-07-23 | 2021-07-23 | Composition ointment for treating psoriasis, medical cap product and application of composition ointment |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030682A1 (en) * | 1998-11-19 | 2000-06-02 | Roecken Martin | Khellin preparation and the use thereof for topical therapy |
| CN202722628U (en) * | 2012-05-31 | 2013-02-13 | 中国人民解放军第三军医大学第一附属医院 | Medicating cap for head |
| CN111840505A (en) * | 2020-08-26 | 2020-10-30 | 黄蜀 | Traditional Chinese medicine preparation and plaster for treating psoriasis and preparation method thereof |
-
2021
- 2021-07-23 CN CN202110835724.8A patent/CN114129627A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030682A1 (en) * | 1998-11-19 | 2000-06-02 | Roecken Martin | Khellin preparation and the use thereof for topical therapy |
| CN202722628U (en) * | 2012-05-31 | 2013-02-13 | 中国人民解放军第三军医大学第一附属医院 | Medicating cap for head |
| CN111840505A (en) * | 2020-08-26 | 2020-10-30 | 黄蜀 | Traditional Chinese medicine preparation and plaster for treating psoriasis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孙尚见: "《周超凡临证用药经验集锦》", 31 January 2009, 人民军医出版社 * |
| 邓辉: "化学疗法、全反式维甲酸及当归的体外抗血管新生作用研究", 《中国博士学位论文全文数据库》 * |
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