CN114127100A - 嵌合的人乳头瘤病毒39型l1蛋白 - Google Patents
嵌合的人乳头瘤病毒39型l1蛋白 Download PDFInfo
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- 238000003989 weak cation exchange chromatography Methods 0.000 description 1
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Abstract
本发明公开了嵌合的人乳头瘤病毒39型L1蛋白和编码其的多核苷酸，还公开了HPV 39型病毒样颗粒和其制备方法。所述嵌合的人乳头瘤病毒39型L1蛋白包含衍生于HPV 39型L1蛋白的N端片段，所述N端片段保持HPV 39型L1蛋白的免疫原性；和衍生于第二型别乳头瘤病毒L1蛋白的C端片段，所述第二型别乳头状瘤病毒L1蛋白具有相较于其他型别的L1蛋白表达量和可溶性较好的特性；其中所述嵌合的HPV 39型L1蛋白具有HPV 39型L1蛋白的免疫原性。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019106572204 | 2019-07-19 | ||
| CN201910657220 | 2019-07-19 | ||
| PCT/CN2020/102602 WO2021013072A1 (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人乳头瘤病毒39型l1蛋白 |
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| CN114127100A true CN114127100A (zh) | 2022-03-01 |
| CN114127100B CN114127100B (zh) | 2024-04-02 |
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| WO (1) | WO2021013072A1 (zh) |
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| MX2023008306A (es) * | 2021-01-14 | 2023-07-19 | Sinocelltech Ltd | Preparacion estable de una vacuna con particulas similares al virus de papilomavirus humano. |
| CN113667683B (zh) * | 2021-08-25 | 2023-02-10 | 上海博唯生物科技有限公司 | 一种表达hpv 39l1的多核苷酸及其表达载体、宿主细胞和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040224305A1 (en) * | 2000-06-21 | 2004-11-11 | Wilson Susan D. | Chimeric human papillomavirus (HPV) L1 molecules and uses therefor |
| CN101245099A (zh) * | 2007-02-14 | 2008-08-20 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的氨基酸序列及其应用 |
| CN107188966A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821087A (en) * | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| CN102747047B (zh) * | 2012-02-28 | 2016-03-23 | 厦门大学 | 人乳头瘤病毒型别杂合病毒样颗粒及其制备方法 |
| CN106795518A (zh) * | 2014-06-19 | 2017-05-31 | 科罗拉多大学董事会，法人 | 人类乳头瘤病毒构建体 |
| CN106831961B (zh) * | 2015-12-04 | 2019-11-05 | 厦门大学 | 一种人乳头瘤病毒58型l1蛋白的突变体 |
| CN107188967B (zh) * | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
-
2020
- 2020-07-17 CN CN202080051823.0A patent/CN114127100B/zh active Active
- 2020-07-17 WO PCT/CN2020/102602 patent/WO2021013072A1/zh active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040224305A1 (en) * | 2000-06-21 | 2004-11-11 | Wilson Susan D. | Chimeric human papillomavirus (HPV) L1 molecules and uses therefor |
| CN101245099A (zh) * | 2007-02-14 | 2008-08-20 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的氨基酸序列及其应用 |
| CN107188966A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
Non-Patent Citations (2)
| Title |
|---|
| MATHIEU BOXUS, ET AL: "Broad cross-protection is induced in preclinical models by a human papollomavirus vaccine composed of L1/L2 chimeric virus-like particles.", J VIROL, ET AL., vol. 90, no. 14, pages 6314 - 6325, XP055422243, DOI: 10.1128/JVI.00449-16 * |
| 郝亚茹,等: "HPV31 L1 C 端截短基因 可在昆虫细胞表达体系中高水平制备 L1 VLP 疫苗", 基础医学与临床, vol. 39, no. 3, pages 343 - 347 * |
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| WO2021013072A1 (zh) | 2021-01-28 |
| CN114127100B (zh) | 2024-04-02 |
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