CN114127099A - 嵌合的人乳头瘤病毒6型l1蛋白 - Google Patents
嵌合的人乳头瘤病毒6型l1蛋白 Download PDFInfo
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Abstract
提供了一种嵌合的人乳头瘤病毒6型L1蛋白和编码其的多核苷酸，还提供了HPV 6型病毒样颗粒和其制备方法。所述嵌合的人乳头瘤病毒6型L1蛋白包含衍生于HPV 6型L1蛋白的N端片段，所述N端片段保持HPV 6型L1蛋白的免疫原性；和衍生于第二型别乳头瘤病毒L1蛋白的C端片段，所述第二型别乳头状瘤病毒L1蛋白具有相较于其他型别的L1蛋白表达量和可溶性较好的特性；其中所述嵌合的HPV 6型L1蛋白具有HPV 6型L1蛋白的免疫原性。所述嵌合的人乳头瘤病毒6型L1蛋白具有较高的表达量和可溶性，可用于疫苗的大规模生产。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910666205 | 2019-07-19 | ||
| CN2019106662056 | 2019-07-19 | ||
| PCT/CN2020/102584 WO2021013067A1 (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人乳头瘤病毒6型l1蛋白 |
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| CA3204802A1 (en) * | 2021-01-14 | 2022-07-21 | Yan Liu | Stable preparation of human papillomavirus virus-like particle vaccine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106831960A (zh) * | 2015-12-04 | 2017-06-13 | 厦门大学 | 一种人乳头瘤病毒6型l1蛋白的突变体 |
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| CA2202090C (en) * | 1994-10-07 | 2012-04-17 | Lutz Gissmann | Papilloma virus-like particles, fusion proteins as well as processes for their production |
| US6228368B1 (en) * | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
| CN102497880A (zh) * | 2009-06-25 | 2012-06-13 | 葛兰素史密丝克莱恩生物有限公司 | 新的人乳头状瘤病毒(hpv)蛋白构建体及其在预防hpv疾病中的用途 |
| CN102747047B (zh) * | 2012-02-28 | 2016-03-23 | 厦门大学 | 人乳头瘤病毒型别杂合病毒样颗粒及其制备方法 |
| CN104418942A (zh) * | 2013-08-30 | 2015-03-18 | 长春百克生物科技股份公司 | 截短的人乳头瘤病毒的l1蛋白、其类病毒颗粒及其制备方法和应用 |
| CN106831958B (zh) * | 2015-12-04 | 2020-12-29 | 厦门大学 | 一种人乳头瘤病毒11型l1蛋白的突变体 |
| CN107188966B (zh) * | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
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| CN106831960A (zh) * | 2015-12-04 | 2017-06-13 | 厦门大学 | 一种人乳头瘤病毒6型l1蛋白的突变体 |
Non-Patent Citations (2)
| Title |
|---|
| CHRISTENSEN，N.D.等: "Hybrid papillomavirus L1 molecules assemble into virus-like particles that reconstitute conformational epitopes and induce neutralizing antibodies to distinct HPV types" * |
| 金石: "人乳头瘤病毒（HPV）衣壳蛋白L1的体外可控组装" * |
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| CN114127099B (zh) | 2024-04-19 |
| WO2021013067A1 (zh) | 2021-01-28 |
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