CN114097794A - Synergistic composition containing pyrazole amide compounds - Google Patents

Synergistic composition containing pyrazole amide compounds Download PDF

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CN114097794A
CN114097794A CN202010881665.3A CN202010881665A CN114097794A CN 114097794 A CN114097794 A CN 114097794A CN 202010881665 A CN202010881665 A CN 202010881665A CN 114097794 A CN114097794 A CN 114097794A
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fenpyrad
agent
sodium
polyoxyethylene ether
composition
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Inventor
唐剑峰
王丹丹
刘杰
迟会伟
李颖
刘振邦
赵恭文
郭强
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SHANDONG UNITED PESTICIDE INDUSTRY CO LTD
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SHANDONG UNITED PESTICIDE INDUSTRY CO LTD
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring

Abstract

The invention belongs to the technical field of pesticide compounding, and particularly relates to a synergistic composition containing pyrazole amide compounds, and an application of the composition. The effective components in the composition are LH-371 and an active component B, the LH-371 and the active component B are mixed and have obvious synergistic and complementary effects, and the composition can act on pathogenic bacteria at multiple sites by utilizing different action sites and different action mechanisms of pathogenic bacteria, so that the bactericidal spectrum is enlarged, the control effect is improved, the use amount of pesticides is reduced, the generation of drug resistance is delayed, and the cost can be reduced.

Description

Synergistic composition containing pyrazole amide compounds
Technical Field
The invention belongs to the technical field of pesticide compounding, and particularly relates to a synergistic composition containing pyrazole amide compounds, and an application of the composition.
Background
Among the pest control of crops, chemical control is still dominant. Although the chemical prevention and treatment is time-saving and labor-saving and has obvious effect, the chemical prevention and treatment also has serious disadvantages. For example, the long-term use of a large amount of a single chemical pesticide can form a directional selection for pests, germs and weeds, so that the drug resistance of the pests, germs and weeds is increased continuously. With the increasing of pest resistance, the dosage of pesticide must be increased continuously to kill the drug-resistant pests and weeds, so that the production cost of agriculture is increased, the natural enemies of the pests are killed, and the pests of crops are frequently caused. More seriously, the use of a large amount of chemical pesticides also aggravates environmental pollution and damages human health.
Therefore, reasonable pesticide mixing can not only generate synergistic effect, but also the pesticide is lack of directional selection for pests when being compounded and used according to different proportions, can delay the generation of drug resistance of pests and weeds, and the pesticide compounding with different action mechanisms can improve the control effect, reduce the use amount of the pesticide, and has good economic benefit and good ecological and social benefit. Under the condition that new technical products are more and more difficult to develop, the pesticide compounding technology is more and more emphasized, and becomes one of important ways for developing new pesticide products at present. Although formulation techniques are well known to scientists as having a number of advantages, it is challenging to select appropriate drugs for formulation to achieve a synergistic effect, because antagonism, or lack of synergy, may occur between different drugs due to differences in active sites.
Disclosure of Invention
The invention provides a synergistic composition containing a pyrazole amide compound and an active ingredient B, wherein the pyrazole amide compound has a chemical name of N- (2- (2, 4-bis (trifluoromethyl) phenoxy) phenyl) -3- (difluoromethyl) -1-methyl-1H-pyrazole-4-amide, and has a chemical formula as follows:
Figure BDA0002651734740000011
Figure BDA0002651734740000021
the active ingredient B is selected from any one of the following compounds: fungicides (such as thifluzamide, epoxiconazole, fluxaflufen, fluxapyroxad, benzovindiflupyr, iprodione, pyraziflumumi, Isoflucypram, Inpyrfluxam, pyraproproyne, bixafen, fluxapyroxad, fluindazinam, benalaxyl, furalaxyl, metalaxyl, mefenoxam, oxadixyl, furalaxyl, bupirimate, dimethirimol, hymexazol, octreox, quinazone, benomyl, carbendazim, fuberidazole, thiophanate-methyl, diethofencarb, zoxamide, pencycuron, fluoxaflufen, triflumimide, fenbutamide, fenpyrad, fluopyram, meturacilamide, meturazamide, carboxin, thiflusulfamide, furametpyr, pyraflufen, penflufen, fenpyrazofen, fenpyrazox, fenpyraclostrobin, trifloxystrobin, fenpyrad, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, fenchloral, fenpyrad, fenpyraclostrobin, fenpyrad, fenchloral, fenpyrad, fenchlorantraniliprol, fenpyrad, fenpyraclostrobin, fenpyrad, fenchloral, fenpyrad-p-chloride, fenpyrad, fenpyra, Triphenyl tin hydroxide, silthiopham, ametoctradin, sodium disulfate, cyprodinil, mepanipyrim, pyrimethanil, fenfluramine, kasugamycin, streptomycin, terramycin, thifluzazole and copper, zinc salts, phenoxyquinoline, propoxymidine, fenpiclonil, fludioxonil, ethiprole, iprodione, procymidone, ethephon, edifenphos, diphenphos, iprobenfos, pirophos, isoprothiolane, diclomethazine, niclosamide, pentachloronitrobenzene, tetrachloronitrobenzene, tolclofos-methyl, hymexazol, iodopropynyl butylmethylamine ester, propamocarb, thiocarb, dimethomorph, flumorph, benthiavalicarb, iprovalicarb, mandipropamid, bacillus subtilis, dodecamorpholine, fenpropimorph, tridecorph, fenpropidin, spiroxamide, fenhexamid, propyzamide, naftifine, terbinafine, validamycin, tetrachlorvinphos, mephitin, mephitrin, pyributhrix, fenpyr, fenpyrad, fenpyralid, fentebufen, terbinax, fenpyrad, fentebufen, fenpyrad, fentebufen, fenphos, fenpyrad, fenphos, fenpyrad, fenpyr, fenpyrad, fenphos, fenpropathrin, fenpyr, fenphos, fenpyr, fenpropathrin, fenpyrad, fenpyr, fenpyrad, fenflurbenflurbenfluralin, fenpyr, fenflurbenflurbenflurbenfluralin, fenfluralin, fenpyr, fenpyrad, fenpyr, fenpyrad, fenpyr, fenpyrad, fluquinazone, tricyclazole, cyclopropamocarb, diclorocyanide, fenoxanil, acibenzolar-methyl, probenazole, tiadinil, isotianil, algal polysaccharide, cymoxanil, fosetyl-aluminum, phosphorous acid and salts, imidazozine, sulfsulfamide, pyridaben, sulbencarb, ethaboxam, cyflufenamid, metrafenone, dodecylguanidineacetate, mineral oil, organic oil, potassium bicarbonate, a biogenic material, copper sulfate, basic copper sulfate, cupric oxychloride, copper hydroxide, cuprous oxide, the amino acids coppicrate, sulfur, ferbam, mancozeb, maneb, metiram, propineb, thiram, zineb, thiram, captan, captafol, folpet, chlorothalonil, benfluanid, octocrylonite, iminoctadine, trichlorfon, fenaminoxidine, dithianon).
Insecticides (such as chlorantraniliprole, fipronil, sulfoxaflor, spinetoram, pyriproxyfen, pymetrozine, flonicamid, clofentezine, propargite, chlorfenapyr, cyromazine, pyridaben, spirotetramat, cyflumetofen, methamidophos, methyl parathion, acephate, phorate, malathion, chlorpyrifos, dimethoate, omethoate, dichlorvos, terbufos, diazinon, fenitrothion, methidathion, profenofos, quinalphos, butylpyrimidine (for soil treatment, high toxicity), fosthiazate, fenamiphos, monocrotophos, triazophos, thion, phos, phosmet, foscarnet, fluvalin, deltamethrin, lambda-cyhalothrin, cypermethrin, bifenthrin, cis-cypermethrin, S-fenvalerate, tefluthrin, cyhalothrin, fluthrin, fluvalicarb, fluvalinate, fluvalicarb, flufen, chlorpyrifos, and so, chlorpyrifos, and other, chlorpyrifos, and other, cyhalothrin, ethofenprox, permethrin, fenvalerate, cyfluthrin, fenpropathrin, diafenprox, cycloprothrin, brodifenthrin, flucythrinate, tralomethrin, gamma-cyhalothrin, proffluthrin, metofluthrin, tetrafluoroethane, mecarb, methomyl (high toxicity), carbofuran (high toxicity), aldicarb, thiodicarb, benfuracarb, carbosulfan, oxamyl, methiocarb, fenoxycarb, pirimicarb, bendiocarb, valicarb, isoprocarb, furacarb, methiocarb, ethiofencarb, propoxur, cartap, dimehypo, monosultap, thiocyclam, chlorfenapyr, nitenpyram, thiacloprid, clothianidin, abamectin, spinosad, dimethomocide, metin, metrafludwith, sumicin, methoprene, methomyl, imidacloprid, thiamethoxam, acetamiprid, nited, thiacloprid, tebufalin, tefuran, tebufalin, te, Emamectin benzoate, sulfomethacin, thiocyclam, beauveria bassiana, metarhizium, lufenuron, flufenoxuron, diflubenzuron, novaluron, flufenoxuron, chlorfluazuron, triflumuron, hexaflumuron, chlorbenzuron, chlorfluazuron, endosulfan, dicofol, lindane).
According to an embodiment of the invention, the mass ratio of the LH-371 to the active ingredient B is 80-1: 1-80, preferably 70-1: 1-70, such as 60-1: 1-70, 50-1: 1-70, 40-1: 1-70, 30-1: 1-70, 20-1: 1-70, 10-1: 1-70.
According to an embodiment of the invention, the composition further comprises various adjuvants, wherein the active ingredient is present in an amount of 1% to 90%, preferably 5% to 80%, for example 70%, 60%, 50%, 40%, 30% or 20% by weight of the total weight.
According to an embodiment of the present invention, the composition may be prepared as a liquid formulation or a solid formulation.
According to the embodiment of the invention, the composition can be prepared into a suspending agent, a wettable powder, a water dispersible granule, a suspending agent, an emulsion in water or a suspended seed coating.
According to an embodiment of the invention, the active ingredient content of the formulation varies according to the type of formulation, generally a liquid formulation contains 1% to 60% by weight of active substance, preferably 5% to 50%; the solid preparation contains 5-80% by weight of active substance, preferably 10-70%.
According to an embodiment of the invention, the composition comprises at least one surfactant to facilitate dispersion of the active ingredient in water upon application. The content of the surfactant accounts for 2-30% of the total weight of the preparation, and the balance is solid or liquid diluent.
According to an embodiment of the invention, the surfactants chosen for the composition are known to the person skilled in the art: can be selected from one or more of dispersing agent, wetting agent, thickening agent or defoaming agent.
According to embodiments of the present invention, the formulation may further comprise adjuvants such as stabilizers, antifreezes, and the like, which are well known to those skilled in the art.
According to an embodiment of the invention, the composition may be diluted by the user before use or used directly. The formulation may be prepared by processes known to those skilled in the art, i.e., mixing the active ingredient with a liquid solvent or solid carrier, and adding one or more surfactants such as dispersants, stabilizers, wetting agents, binders, defoamers, etc.
According to the embodiment of the invention, the composition comprises the following components in percentage by weight when prepared into wettable powder: LH-3711-80%, active component B1-80%, dispersant 1-12%, wetting agent 1-8%, and the balance of filler, for example, the following wettable powder is prepared: LH-37120%, fluorothiazole pyrithylone 5%, sodium dodecyl sulfate 2%, sodium lignosulfonate 5%, white carbon black 10% and kaolin to make up to 100%; or LH-37125%, thifluzamide 15%, sodium dodecyl sulfate 2%, sodium lignosulphonate 5%, white carbon black 10% and kaolin to make up to 100%.
According to the embodiment of the invention, the composition comprises the following components in percentage by weight when prepared into water dispersible granules: LH-3711-80%, active ingredient B1-80%, dispersing agent 1-12%, wetting agent 1-8%, disintegrating agent 1-10%, binding agent 1-8%, and the balance of filler, for example, the following water dispersible granules are prepared: LH-37115%, boscalid 15%, sodium alkyl naphthalene sulfonate 5%, sodium lignin sulfonate 7%, sodium dodecyl sulfate 2%, ammonium sulfate 5%, and light calcium carbonate to make up to 100%.
According to the embodiment of the invention, the composition is prepared into a suspending agent and comprises the following components in percentage by weight: LH-3711% -50%, active component B1% -50%, dispersant 1% -12%, wetting agent 1% -10%, thickening agent 0.1% -2%, antifreeze agent 0.1% -8%, deionized water to make up to 100%, for example make the following suspension: LH-3715%, fluoride ether bacteria amide 5%, sodium methyl naphthalene sulfonate formaldehyde condensate 9%, xanthan gum 2%, sodium lignin sulfonate 4%, bentonite 1%, glycerol 5%, and water to 100%; or the like, or, alternatively,
LH-37110%, Cyanostrobin 10%, sodium methyl naphthalene sulfonate formaldehyde condensate 9%, xanthan gum 2%, sodium lignosulfonate 4%, bentonite 1%, glycerol 5%, and water to 100% or,
LH-37120%, dimethomorph 20%, sodium methyl naphthalene sulfonate formaldehyde condensate 9%, xanthan gum 2%, sodium lignin sulfonate 4%, bentonite 1%, glycerol 5%, water to 100%, or,
LH-37120%, metrafenone 10%, sodium methyl naphthalene sulfonate formaldehyde condensate 9%, xanthan gum 2%, sodium lignosulfonate 4%, bentonite 1%, glycerol 5% and water to make up to 100%.
According to the embodiment of the invention, the composition is prepared into an aqueous emulsion and comprises the following components in percentage by weight: LH-3711% -50%, active component B1% -50%, organic solvent 1% -20%, emulsifier 1% -12%, optionally antifreeze agent 0.1% -8%, defoaming agent 0.01% -2%, thickening agent 0.1% -2%, deionized water to make up to 100%, for example make into the following aqueous emulsion: LH-3715%, isoprothiolane 5%, emulsifier (NP-10, span-80, Tween-20) 10%, ethylene glycol 3%, defoaming agent (n-octanol) 0.5%, thickener (xanthan gum) 0.3%, and deionized water to make up to 100%.
According to the embodiment of the invention, the composition is prepared into a suspended seed coating (FS) and comprises the following components in percentage by weight: LH-3711-50%, active component B1-50%, dispersing agent 2-10%, anti-freezing agent 0.1-5%, anti-caking agent 0.1-10%, suspending agent 0.1-5%, film-forming agent 1-10%, preservative 0.1-5%, coloring agent 0.1-5%, pH regulator 0.1-5%, deionized water to make up to 100%, for example, FS: LH-37125%, nitenpyram 25%, sodium lignosulphonate 8.5%, ethylene glycol 2.5%, sodium aluminosilicate 4%, xanthan gum 1%, polyvinyl alcohol 5%, sodium benzoate 1.5%, acid scarlet 1%, and deionized water to make up to 100%;
or the like, or, alternatively,
LH-37110%, thiamethoxam 30%, sodium lignosulfonate 8.5%, ethylene glycol 2.5%, sodium aluminosilicate 4%, xanthan gum 1%, polyvinyl alcohol 5%, sodium benzoate 1.5%, acid scarlet 1%, and deionized water to make up to 100%;
or the like, or, alternatively,
LH-37115%, clothianidin 35%, sodium lignosulfonate 8.5%, ethylene glycol 2.5%,
4% of sodium aluminosilicate, 1% of xanthan gum, 5% of polyvinyl alcohol, 1.5% of sodium benzoate, 1% of acid scarlet and deionized water for supplementing to 100%.
According to an embodiment of the present invention, the emulsifier may be selected from one of the following: one or more of sodium dodecyl sulfate, calcium dodecyl benzene sulfonate, sodium lignosulfonate, agricultural emulsion, sodium dodecyl benzene sulfonate, calcium dodecyl benzene sulfonate, phenyl phenol polyoxyethylene ether phosphate, naphthalene sulfonate formaldehyde condensate, benzyl dimethyl phenol polyoxyethylene ether, styryl phenyl polyoxyethylene ether, phenethyl phenol polyoxyethylene polyoxypropylene ether, sorbitan monostearate polyoxyethylene ether, span-80, sorbitan fatty acid ester polyoxyethylene ether, tween-20, fatty alcohol polyoxyethylene ether, NP-10, nonylphenol polyoxyethylene ether phosphate and castor oil polyoxyethylene ether phosphate;
according to an embodiment of the present invention, the dispersant may be selected from: one or more of glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, sodium lignosulfonate, fatty alcohol polyoxyethylene ether sulfate, naphthalene sulfonate formaldehyde condensate sodium salt, nonylphenol polyoxyethylene ether, polyoxyethylene lanolin alcohol, alkylphenol polyoxyethylene ether formaldehyde condensate, fatty alcohol polyoxyethylene ether phosphate and polyoxyethylene sorbitan fatty acid ester;
according to an embodiment of the present invention, the wetting agent may be selected from: one or more of trisiloxane polyoxyethylene ether, N-lauroyl sodium glutamate, sodium dodecyl sulfate, sodium lauroyl sarcosinate, castor oil polyoxyethylene ether, triphenyl ethylphenol polyoxyethylene ether, calcium dodecyl benzene sulfonate, isooctyl alcohol succinic acid sodium acetate sulfonate, fatty alcohol polyoxyethylene ether, alkyl naphthalene sodium sulfonate, methyl naphthalene sodium sulfonate formaldehyde condensate and lauryl sodium sulfate;
according to an embodiment of the present invention, the binder may be selected from: one or more of xanthan gum, starch, gelatin, arabic gum, carboxymethyl cellulose and carboxyethyl cellulose;
according to an embodiment of the invention, the disintegrant may be selected from: one or more of sodium bicarbonate, ammonium sulfate, sulfuric acid, sodium sulfate, calcium sulfate and magnesium chloride;
according to an embodiment of the present invention, the thickener may be selected from: one or more of magnesium aluminum silicate, polyvinyl acetate, xanthan gum, gelatin, arabic gum, polyvinyl alcohol and bentonite;
according to an embodiment of the present invention, the defoaming agent may be selected from: one or more of n-octanol, silicone, butyl phosphate vinegar and isobutyl phosphate vinegar;
according to an embodiment of the invention, the antifreeze agent can be selected from: one or more selected from propylene glycol, ethylene glycol, glycerol, etc.;
according to an embodiment of the invention, the stabilizer may be selected from: one or more of epichlorohydrin, butyl glycidyl ether, triphenyl phosphite, N-soybean oil-based trimethylene diamine, dialkyl succinic acid acetate sulfonate and the like;
according to an embodiment of the present invention, the filler and/or carrier comprises a solid filler and/or carrier and a liquid filler and/or carrier, wherein the solid filler and/or carrier may be selected from: one or more of kaolin, attapulgite, diatomite, white carbon black, bentonite, montmorillonite and calcium carbonate. The liquid filler and/or carrier may be selected from one or more of water, soybean oil, castor oil, mineral oil.
According to an embodiment of the present invention, the organic solvent may be selected from: one or more of ethyl acetate, acetone, isopropanol, benzene, toluene, xylene, dimethylformamide, dimethyl sulfoxide, dichloromethane, cyclohexane, cyclohexanone, N-methylpyrrolidone.
According to the embodiment of the invention, the preparation formulation comprises suspending agent, aqueous emulsion, water dispersible granule, microcapsule suspending agent, microcapsule suspension-suspending agent, dispersible liquid, microemulsion, wettable powder, suspoemulsion, missible oil, suspended seed coating agent, seed treatment emulsion, seed treatment liquid, granule and hot fogging concentrate.
The present invention also provides a process for preparing the composition as described above, comprising: mixing active ingredient LH-371 and active ingredient B with adjuvant.
The invention also provides the composition, preferably an application of a preparation of the composition in controlling plant diseases and insect pests such as downy mildew of melons, cucumber target spot disease, cucumber gray mold, tomato gray mold, potato late blight, cucumber powdery mildew, cucumber anthracnose, cucurbit scab, rice blast, wheat scab, wheat rust, wheat powdery mildew, wheat sharp leaf blight, rice sheath blight, soybean rust, corn rust, garlic rust, potato black nevus, peanut southern blight, rape sclerotinia rot, brown rot, peanut brown spot, citrus scab, aleyrodid, aphids (such as wheat aphids), thrips, grubs, green plant bugs, rice leaf rollers, bean stem borers, plutella xylostella, beet armyworm, prodenia litura and the like.
The synergistic composition containing the active ingredient LH-371 and the active ingredient B can be provided in the form of a finished product preparation or a single agent, is directly mixed before use, is then mixed with water to be prepared into a required concentration, and is irrigated to plant roots. For specific applications, the composition may also be used in combination with other agents such as insecticides, growth regulators, soil conditioners, herbicides, nematicides, and the like.
The synergistic composition containing the LH-371 and the active component B has the following advantages: 1. has synergistic effect and can improve the control effect; 2. the bactericidal spectrum or the insecticidal spectrum is expanded, the field diseases and insect pests are mixed, and the LH-371 and the active ingredient B are mixed for preventing the diseases and the insect pests; 3. the two effective components have different action mechanisms, and the generation of drug resistance of pests is delayed by mixing; 4. the application amount is reduced, the use times are reduced, and the use cost is reduced.
In conclusion, the effective components in the composition are LH-371 and an active component B, the LH-371 and the active component B are mixed and have obvious synergistic and complementary effects, and the composition can act on pathogenic bacteria at multiple sites by utilizing different action sites and different action mechanisms of pathogenic bacteria, so that the bactericidal spectrum is enlarged, the control effect is improved, the use amount of pesticides is reduced, the generation of drug resistance is delayed, and the cost can be reduced.
Detailed Description
The technical solution of the present invention will be further described in detail with reference to specific embodiments. It is to be understood that the following examples are only illustrative and explanatory of the present invention and should not be construed as limiting the scope of the present invention. All the technologies realized based on the above-mentioned contents of the present invention are covered in the protection scope of the present invention.
Unless otherwise indicated, the raw materials and reagents used in the following examples are all commercially available products or can be prepared by known methods.
Unless otherwise specified, the inventive content of the present application and the proportions or ratios in the following examples are given in weight percent.
The abbreviation "TC" in the following examples refers to the technical drug.
The embodiment of the invention adopts a method combining indoor toxicity measurement and field test. Firstly, determining the Synergy Ratio (SR) of two medicaments compounded according to a certain proportion by indoor toxicity measurement, wherein SR <0.5 is antagonism, SR < 1.5 is not less than 0.5 is additive action, and SR < 1.5 is synergistic action, and then carrying out field test on the basis.
First, an indoor toxicity test example
The test method comprises the following steps: referring to the agricultural industry standard NY/T1156.2-2006 of the people's republic of China, firstly, 5 different concentration gradients are set for single agent and each to-be-mixed combination (on the basis of a pre-test result, the concentration gradients are set differently according to different agent combinations and proportions, and the bacteriostasis rate is set according to an equal ratio series within the range of 5% -90%), and clear water is set for comparison. Specifically, the method is carried out by referring to ' pesticide indoor bioassay test criterion bactericide ' in agricultural industry standard NY/T1156.2-2006 of the people's republic of China, and the toxicity of the medicament to crop germs is determined by adopting a hypha growth rate method. And measuring the colony diameter by a cross method after 72h, and calculating the net growth amount and the hypha growth inhibition rate of each group.
The net growth (mm) is the measurement of colony diameter (mm) -5mm
Hypha growth inhibition rate (%). 100%. The control group net growth amount-the treatment group net growth amount)/the control group net growth amount
Converting the hypha growth inhibition rate into a probability value (y), converting the drug solution concentration (mu g/mL) into a logarithm value (x), obtaining a virulence regression equation (y is a + bx) by a least square method, and calculating the EC of each drug50The value is obtained. Meanwhile, the combined Synergistic Ratio (SR) of the two medicaments in different proportions is calculated according to the Wadley method, the antagonism is achieved when the SR is less than or equal to 0.5, the addition is achieved when the SR is more than 0.5 and less than 1.5, and the synergism is achieved when the SR is more than or equal to 1.5. The calculation formula is as follows:
SR＝EC50(theoretical value)/EC50(actual measurement value)
EC50(theoretical value) ═ EC of (a + b)/[ (a/A)50) + (EC of B/B50)]
In the formula: a is LH-371, B is selected from thifluzamide, epoxiconazole, flufenapyr, benzovindiflupyr, iprodione, pyraziflumumi, Isoflucypram, Inpyrfluxam, pyraproyne, bixafen, fluxapyroxad, flurindoxamine, benalaxyl, furalaxyl, metalaxyl, mefenoxam, metalaxyl, furalaxyl, bupirimate, dimetrimol, hymexazol, octreone, quinconazole, benomyl, carbendazim, fuberidazole, thiophanate-methyl, diethofencarb, zoxamide, pencycuron, fluopyram, furazol, fenpyrad, fenpyrazamine, fenpyrazamide, fenpyraclostrobin, trifloxystrobin, fenpyraclostrobin, flufenamate, fenpyraclostrobin, flufenazam, fenpyraclostrobin, flufenazamide, flufenacetuxifen-p-ethyl, fenpyraclostrobin, flufenap-p-ethyl, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, flufenac, fenpyraclostrobin, flufenap-isopropyl, fenpyrad, fenpyraclostrobin, flufenap-p-ethyl, flufenazam, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, flufen-p-ethyl, fenpyrad, fenpyraclostrobin, flufenac, fenpyrad, flufenac, fenpyrad, flufenap-ethyl, flufenap-p-ethyl, fenpyrad, flufenac, flubenconazole, flufenap-ethyl, flufenac, flufenap-p-ethyl, flubenconazole, flufenapyr-ethyl, flufenapyr, flubenconazole, flufenap-ethyl, flufenapyr-ethyl, flufenap-ethyl, flufenapyr-ethyl, flufenapyr-d, flufenapyr, Tristannylchloride, triphenyltin hydroxide, silthiopham, ametoctradin, sodium disulfate, cyprodinil, mepanipyrim, pyrimethanil, fenamiphos, kasugamycin, streptomycin, terramycin, thifluzazole and copper, zinc salts, quinoxyfen, proquinazine, fenpiclonil, fludioxonil, chlozolinate, iprodione, procymidone, ethephon, diphenphos, iprobenfos, pirophosphate, isoprothiolane, diclomelane, niclosamide, quintozene, tetrachloronitrobenzene, tolclofos-methyl, hymexazol, propamocarb, dimethomorph, flumorph, benthiavalicarb, iprovalicarb, mandipropamid, bacillus subtilis, dodecamorph, fenpropimorph, tridemorph, fenpropidin, spiroxamide, fenhexamid, propachlor, nafil, naftifine, terbinafine, validamycin, doxycycline, Any one of tetrachlorophthalide, pyroquilon, tricyclazole, cyclopropamocarb, diclorocyanide, fenoxanil, activated ester, probenazole, tiadinil, isotianil, algal polysaccharide, cymoxanil, fosetyl-aluminum, phosphorous acid and salts, imidazozine, sulfenamide, pyridaben, sulbencarb, ethaboxam, cyflufenamid, metrafenone, dodecylguanidineacetate, mineral oil, organic oil, potassium bicarbonate, biogenic materials, copper sulfate, basic copper sulfate, cupric oxychloride, copper hydroxide, cuprous oxide, copper amino acid complex, sulfur, ferbam, mancozeb, maneb, metiram, propineb, thiram, zineb, thiram, captan, captafol, folpet, chlorothalonil, benfluanid, metribuzin, iminoctadine, trichlorfon, fenaminosulf, dithianon; a and B are respectively the proportion of LH-371 and the active component B in the combination.
Example 1:
diseases to be tested: target spot of cucumber
Reagent to be tested: LH-371TC and fluoroether bacteria amide TC are provided by Shandong Zhongnong's Union Biotech, Inc.
And (3) experimental design: the effective inhibition concentration range of the LH-371, the fluoride ether bacteria amide and the mixture of the LH-371 and the fluoride ether bacteria amide in different proportions is determined through a preliminary test.
And (3) virulence determination results:
TABLE 1 analysis table of toxicity test results of cucumber target spot compounded by LH-371 and fluoroether bacteria amide
Figure BDA0002651734740000081
Figure BDA0002651734740000091
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 1, when the ratio of LH-371 to fluoroether bacteria amide for preventing and treating cucumber target spot is 1: 70-70: 1, the synergistic effect is achieved, and the synergistic values are all more than 1.5.
Example 2:
diseases to be tested: downy mildew of cucumber
Reagent to be tested: LH-371TC and fluorothiazole pyrithylone TC are provided by Shandong Zhongnong's Co., Biotechnology Co., Ltd.
And (3) experimental design: the effective inhibition concentration range of the LH-371, the fluorothiazole pyrithylone and the mixture of the LH-371 and the fluorothiazole pyrithylone in different proportions is determined by a preliminary test.
And (3) virulence determination results:
TABLE 2 toxicity test result analysis table of cucumber downy mildew compounded by LH-371 and fluorothiazole pyrithylone
Figure BDA0002651734740000092
Figure BDA0002651734740000101
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 2, when the ratio of LH-371 to fluorothiazole pyrithylone for controlling cucumber downy mildew is 1: 70-70: 1, the synergistic effect is achieved, and the synergistic ratio SR is more than 1.5.
Example 3:
diseases to be tested: gray mold of tomato
Reagent to be tested: LH-371TC and boscalid TC are both provided by Shandong Zhongnong's Union Biotechnology GmbH.
And (3) experimental design: the effective inhibition concentration range of the LH-371, boscalid and the mixture of the boscalid and the boscalid in different proportions is determined through a preliminary test.
And (3) virulence determination results:
TABLE 3 toxicity test result analysis table of LH-371 compounded with boscalid for tomato gray mold
Figure BDA0002651734740000102
Figure BDA0002651734740000111
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 3, when the ratio of LH-371 to boscalid to control the gray mold of tomatoes is 70: 1-1: 70, the synergistic effect is achieved, and the synergistic ratio SR is more than 1.5.
Example 4:
diseases to be tested: scab of wheat
Reagent to be tested: LH-371TC and Cyanoxastrobin TC are both provided by Shandong Zhongnong's union Biotechnology GmbH.
And (3) experimental design: the effective inhibition concentration range of the LH-371, the phenamacril and the mixture of the two in different proportions is determined through a preliminary test.
And (3) virulence determination results:
TABLE 4 analysis table of toxicity test results of LH-371 and Cyanoxastrobin combination on wheat scab
Figure BDA0002651734740000112
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 4, when the ratio of LH-371 to Cyanoxastrobin for controlling wheat scab is 70: 1-1: 70, the synergistic effect is achieved, and the synergistic ratio SR is more than 1.5.
Example 5:
diseases to be tested: southern blight of peanut
Reagent to be tested: LH-371TC, thifluzamide TC, are both available from Shandong Zhongnong, Union Biotech, Inc.
And (3) experimental design: the effective inhibition concentration range of the LH-371, thifluzamide and the mixture of the LH-371 and the thifluzamide in different proportions is determined through a preliminary test.
And (3) virulence determination results:
TABLE 5 toxicity test result analysis table of LH-371 and thifluzamide pairing peanut southern blight
Figure BDA0002651734740000121
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 5, the combination of LH-371 and thifluzamide has a synergistic effect when the ratio of LH-371 to thifluzamide to control peanut southern blight is 70: 1-1: 70, and the synergistic ratio SR is more than 1.5.
Example 6:
diseases to be tested: blast of rice
Reagent to be tested: LH-371TC, isoprothiolane TC was supplied by Shandong Zhongnong's Union Biotech, Inc.
And (3) experimental design: the effective inhibition concentration range of the LH-371, the isoprothiolane and the mixture of the LH-371 and the isoprothiolane in different proportions is determined through a preliminary test.
Results of virulence determination
TABLE 6 analysis table of toxicity test results of LH-371 and isoprothiolane combination on rice blast
Figure BDA0002651734740000131
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 6, the combination of LH-371 and isoprothiolane has synergistic effect when the ratio of LH-371 to isoprothiolane to the rice blast prevention and control is 70: 1-1: 70, and the synergistic ratio SR is more than 1.5.
Example 7:
diseases to be tested: late blight of potato
Reagent to be tested: LH-371TC and dimethomorph TC are provided by Shandong Zhongnong Union Biotech, Inc.
And (3) experimental design: the effective inhibition concentration range of the LH-371 and the dimethomorph and the mixture of the LH-371 and the dimethomorph with different proportions is determined by a preliminary test.
And (3) virulence determination results:
TABLE 7 virulence determination result analysis table of LH-371 and dimethomorph compounded on potato late blight
Figure BDA0002651734740000141
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 7, the LH-371 and dimethomorph are compounded to achieve the synergistic effect when the ratio of the LH-371 to the dimethomorph to the potato late blight prevention and treatment is 70: 1-1: 70, and the synergistic ratio SR is more than 1.5.
Example 8:
diseases to be tested: powdery mildew of wheat
Reagent to be tested: LH-371TC and metrafenone TC are provided by Shandong Zhongnong Union Biotech, Inc.
And (3) experimental design: the effective inhibition concentration range of the mixed agent of LH-371 and metrafenone in different proportions is determined by a preliminary test.
And (3) virulence determination results:
TABLE 8 toxicity test result analysis table of LH-371 and metrafenone for wheat powdery mildew
Figure BDA0002651734740000142
Figure BDA0002651734740000151
The proportion in the table refers to the weight ratio of the raw medicines.
As can be seen from Table 8, the combination of LH-371 and metrafenone in a ratio of 1: 70-70: 1 is synergistic in controlling wheat powdery mildew, and the synergistic ratio SR is more than 1.5.
Second, application example of the preparation
The field control effect on diseases is respectively determined by using a single-component preparation as a control agent of a compound preparation and using the diseases as targets in the following examples. For example, 10% LH-371 suspension and 10% fluoroether carboxamide suspension were used as control agents for the 10% LH-371-fluoroether carboxamide suspension (example 9), and so on. Each treatment is repeated for 4 times, the base numbers of different crop disease pesticides are investigated before pesticide application, the control effect is investigated according to the disease conditions after pesticide application, the spraying method is adopted for pesticide application, the disease conditions are recorded according to national standard or row standard grading standards, and the control effect is calculated.
Figure BDA0002651734740000152
Figure BDA0002651734740000153
The following drugs are all provided by research and development center of Shandong Zhongnong union Biotechnology GmbH.
Example 9: 10% LH-371 fluoride ether bacteria amide suspending agent
Figure BDA0002651734740000154
Figure BDA0002651734740000161
The active ingredients, the dispersant, the thickener, the wetting agent, the antifreeze, the water and the like are uniformly mixed according to the proportion of the formula, and the 10 percent LH-371 fluoride ether bacteria amide suspending agent is obtained after high-speed shearing.
The embodiment is applied to preventing and treating cucumber target spot disease, the 10% LH-371-fluoroether bacteria amide suspending agent is diluted by water and sprayed by 500 times, and the preventing and treating effect 10 days after the application is 81.23%. 10% LH-371 suspending agent according to 500 times, 10% fluoride ether bacteria amide suspending agent (these two medicaments are that the active ingredient is replaced to any one and got in the above proportion) according to 500 times and adding water to dilute and spray, the prevention and cure effect 10 days after the medicine is 65.12%, 69.35% respectively, after two compounds, the synergistic effect is obvious, the prevention and cure effect to the cucumber target spot is obviously better than the single dose; because the effect of the medicament is improved, the dosage of the effective components in the compound medicament is obviously reduced compared with the dosage when the medicament is used alone, thereby reducing the pollution to the environment.
Example 10: 25% LH-371-fluorothiazole pyrithylone wettable powder
Figure BDA0002651734740000162
The active ingredients, various auxiliary agents, fillers and the like are uniformly mixed according to the proportion of the formula, and the mixture is crushed by a superfine pulverizer to obtain 25 percent LH-371-fluorothiazole pyrithylone wettable powder.
The embodiment is used for preventing and treating cucumber downy mildew, 25% LH-371 fluthiazopyracetone wettable powder is diluted by 1250 times of water and sprayed, and the preventing and treating effect 10 days after the spraying is 87.63%. The 20% LH-371 wettable powder is 1000 times of that of the 20% LH-371 wettable powder, and the 10% fluorothiazole pyrithylone dispersible oil suspending agent is 500 times of that of the 10% fluorothiazole pyrithylone dispersible oil suspending agent, and then the 20% LH-371 wettable powder and the 10% fluorothiazole pyrithylone dispersible oil suspending agent are diluted by adding water and sprayed, wherein the control effects after the application for 10 days are 65.21% and 64.56% respectively. The synergistic effect of the two is obvious after the two are compounded, and the control effect on cucumber downy mildew is obviously better than that of a single agent.
Example 11: 30% LH-371 boscalid water dispersible granule
Figure BDA0002651734740000163
Figure BDA0002651734740000171
The active ingredients, various auxiliaries, fillers and the like are uniformly mixed according to a formula proportion, wettable powder is obtained after airflow crushing, a certain amount of water is added for mixing, extruding and granulating, and the 30% LH-371 boscalid water dispersible granule is obtained after drying and screening.
The embodiment is applied to control of tomato gray mold, 30% of LH-371 boscalid water dispersible granules are diluted by water by 1500 times for spraying, and the control effect 10 days after the spraying is 85.62%. The control effect on botrytis cinerea is 68.53% and 73.26% after the 20% LH-371 water dispersible granule is diluted by 1000 times and the 50% boscalid water dispersible granule is diluted by 2500 times of water. The two are compounded, the synergistic effect is obvious, and the control effect on the tomato gray mold is obviously better than that of a single agent. Because the effect of the medicament is improved, the dosage of the effective components in the compound medicament is obviously reduced compared with the dosage when the medicament is used alone, thereby reducing the pollution to the environment.
Example 12: 20% LH-371 Cyanoxastrobin suspending agent
Figure BDA0002651734740000172
The active ingredients, the dispersant, the thickener, the wetting agent, the antifreeze, the water and the like are uniformly mixed according to the proportion of the formula, and the 20 percent LH-371-Cyanoxastrobin suspending agent is obtained after high-speed shearing.
The embodiment is applied to controlling wheat scab, 20 percent of LH-371-Cyanoxastrobin suspending agent is diluted by water and sprayed by 1000 times, and the control effect 10 days after the application is 87.36 percent. The 10% LH-371 suspending agent is diluted by 500 times of water and the 25% phenamacril suspending agent is diluted by 1250 times of water and sprayed, the control effect after 10 days of pesticide application is 73.56% and 76.35% respectively, the synergistic effect is obvious after the two are compounded, and the control effect on wheat scab is obviously better than that of a single agent.
Example 13: 40% LH-371 thifluzamide wettable powder
Figure BDA0002651734740000173
Figure BDA0002651734740000181
The active ingredients, various auxiliary agents, fillers and the like are uniformly mixed according to the proportion of the formula, and the mixture is crushed by a superfine pulverizer to obtain 40 percent LH-371 thifluzamide wettable powder.
The preparation is used for preventing and treating peanut southern blight, 40% LH-371 thifluzamide wettable powder is diluted by water and sprayed by 2000 times, and the prevention and treatment effect 10 days after the pesticide is 88.64%. The 20% LH-371 wettable powder is diluted by 1000 times and 240g/L thifluzamide suspending agent by 1200 times of water and then sprayed, and the control effect after 10 days of pesticide application is 73.63% and 68.75% respectively. The synergistic effect of the two is obvious after the two are compounded, and the control effect on cucumber downy mildew is obviously better than that of a single agent.
Example 14: 10% LH-371 rice blast water emulsion
Figure BDA0002651734740000182
According to the formula requirement, water is used as a medium, the raw medicines, the emulsifier, the antifreeze and other auxiliary agents are added into a batching kettle, the raw medicines, the emulsifier, the antifreeze and other auxiliary agents are uniformly mixed by a high-speed shearing machine to prepare the aqueous emulsion, and the aqueous emulsion is measured and subpackaged after being inspected to be qualified to obtain a finished product.
The embodiment is used for preventing and treating rice blast, 10 percent of LH-371-isoprothiolane water emulsion is diluted by water and sprayed by 500 times, and the prevention and treatment effect 10 days after the application is 85.19 percent. The 20% LH-371 wettable powder is diluted by 1000 times and the 40% isoprothiolane emulsifiable concentrate is diluted by 2000 times by adding water and then sprayed, and the control effect after 10 days of pesticide application is 69.22% and 64.55% respectively. The synergistic effect of the two is obvious after the two are compounded, and the prevention and treatment effect on the rice blast is obviously better than that of a single agent. Because the effect of the medicament is improved, the dosage of the effective components in the compound medicament is obviously reduced compared with the dosage when the medicament is used alone, thereby reducing the pollution to the environment.
Example 15 40% LH-371 Dimethomorph suspension
Figure BDA0002651734740000183
Figure BDA0002651734740000191
The 40 percent LH-371-dimethomorph suspending agent is prepared by uniformly mixing the active ingredients, the dispersing agent, the thickening agent, the wetting agent, the antifreeze agent, water and the like according to the proportion of the formula and shearing at high speed.
The preparation is used for preventing and treating potato late blight, 40% of LH-371-dimethomorph suspending agent is diluted by water and sprayed by 2000 times, and the prevention and treatment effect 10 days after the application is 87.35%. The 20% LH-371 wettable powder is diluted by 1000 times and the 40% isoprothiolane emulsifiable concentrate is diluted by 2000 times by adding water and then sprayed, and the control effects after 10 days of pesticide application are 68.03% and 67.26% respectively. The two are compounded, the synergistic effect is obvious, and the control effect on the potato late blight is obviously better than that of a single agent. Because the effect of the medicament is improved, the dosage of the effective components in the compound medicament is obviously reduced compared with the dosage when the medicament is used alone, thereby reducing the pollution to the environment.
Example 16: 30% LH-371 metrafenone suspension
Figure BDA0002651734740000192
The active ingredients, the dispersant, the thickener, the wetting agent, the antifreeze, the water and the like are uniformly mixed according to the proportion of the formula, and the 30 percent LH-371-metrafenone suspending agent is obtained after high-speed shearing.
The preparation is used for preventing and treating wheat powdery mildew, 30% of LH-371 metrafenone suspending agent is diluted by water and sprayed by 1500 times, and the prevention and treatment effect is 89.33% 10 days after the application. The 20% LH-371 wettable powder is diluted by 1000 times and the 42% metrafenone suspending agent is diluted by 2100 times, and then the wettable powder is sprayed, and the control effect after the pesticide is applied for 10 days is 70.21% and 71.12% respectively. The synergistic effect of the two is obvious after the two are compounded, and the control effect on wheat powdery mildew is obviously better than that of a single agent.
Example 17: 50% LH-371 nitenpyram suspension seed coating agent
Figure BDA0002651734740000193
Figure BDA0002651734740000201
The pH regulator is acetic acid, and the pH value is regulated to 6-7.
The active ingredients, the dispersing agent, the antifreeze agent, the anticaking agent, the suspending agent, the film forming agent, the preservative, the colorant, the pH regulator, the water and the like are uniformly mixed according to the proportion of the formula, and the finished product is obtained by metering and subpackaging after the inspection is qualified.
The embodiment is used for preventing and treating wheat powdery mildew, wheat rust, wheat scab and wheat aphid. The control effects of the 50 percent LH-371 nitenpyram suspension seed coating agent on wheat powdery mildew, wheat rust and wheat scab are respectively 87.63 percent, 89.21 percent and 88.25 percent under the dosage of 600g/100kg of seeds; the control effect on wheat aphids is 82.35 percent. The control effects of the 50% LH-371 suspension seed coating agent on wheat powdery mildew, wheat rust and wheat scab are 82.53%, 79.61% and 82.56% respectively under the condition of 600g/100kg of seeds. The control effect of the 50% nitenpyram suspension seed coating agent on wheat aphids is 73.65% at the dosage of 600g/100kg seeds. The dosage of the effective components in the compounded medicament is obviously reduced compared with the dosage when the effective components are used independently, thereby reducing the pollution to the environment.
Example 18: 40% LH-371 thiamethoxam suspension seed coating agent
Figure BDA0002651734740000202
The pH regulator is acetic acid, and the pH value is regulated to 6-7.
The active ingredients, the dispersing agent, the antifreeze agent, the anticaking agent, the suspending agent, the film forming agent, the preservative, the colorant, the pH regulator, the water and the like are uniformly mixed according to the proportion of the formula, and the finished product is obtained by metering and subpackaging after the inspection is qualified.
The 40% LH-371 thiamethoxam suspension seed coating used for preventing and treating cucumber powdery mildew, wheat powdery mildew and thrips has the prevention and treatment effects on cucumber powdery mildew and wheat powdery mildew which are 81.14% and 89.21% respectively and the prevention and treatment effect on thrips is 84.36% under the condition that 400g/100kg of seeds are used. The 40% LH-371 suspension seed coating agent has 74.22% and 71.30% prevention and treatment effects on cucumber powdery mildew and wheat powdery mildew respectively under the condition that 400g/100kg of seeds are used. The control effect of the 40 percent thiamethoxam suspension seed coating agent on thrips is 80.61 percent under the dosage of 600g/100kg of seeds. The dosage of the effective components in the compounded medicament is obviously reduced compared with the dosage when the effective components are used independently, thereby reducing the pollution to the environment.
Example 19 50% LH-371 clothianidin suspension seed coating
Figure BDA0002651734740000211
The pH regulator is acetic acid, and the pH value is regulated to 6-7.
The active ingredients, the dispersing agent, the antifreeze agent, the anticaking agent, the suspending agent, the film forming agent, the preservative, the colorant, the pH regulator, the water and the like are uniformly mixed according to the proportion of the formula, and the finished product is obtained by metering and subpackaging after the inspection is qualified.
The embodiment is used for preventing and treating southern blight of peanuts, cercospora arachidicola and grub, and the 50% LH-371 clothianidin suspension seed coating agent has the effects of preventing and treating southern blight of peanuts and cercospora arachidicola of 86.34% and 84.23% respectively under the condition that the dosage of 450ml/100kg of seeds is used; the control effect on the grubs is 89.36 percent. The 50% LH-371 suspension seed coating agent has the control effects on southern blight and peanut brown spot of 83.23% and 79.74% respectively at the dosage of 450ml/100kg of seeds. The control effect of the 50% thiamethoxam suspension seed coating agent on grubs is 82.21% under the condition that 450ml/100kg of seed dosage. The dosage of the effective components in the compounded medicament is obviously reduced compared with the dosage when the effective components are used independently, thereby reducing the pollution to the environment.
The embodiments of the present invention have been described above. However, the present invention is not limited to the above embodiment. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A synergistic composition containing pyrazole amide compounds and an active ingredient B, wherein the pyrazole amide compounds have the chemical name of N- (2- (2, 4-bis (trifluoromethyl) phenoxy) phenyl) -3- (difluoromethyl) -1-methyl-1H-pyrazole-4-amide and have the chemical formula:
Figure FDA0002651734730000011
the active ingredient B is selected from any one of the following compounds: fungicides (such as thifluzamide, epoxiconazole, fluxaflufen, fluxapyroxad, benzovindiflupyr, iprodione, pyraziflumumi, Isoflucypram, Inpyrfluxam, pyraproproyne, bixafen, fluxapyroxad, fluindazinam, benalaxyl, furalaxyl, metalaxyl, mefenoxam, oxadixyl, furalaxyl, bupirimate, dimethirimol, hymexazol, octreox, quinazone, benomyl, carbendazim, fuberidazole, thiophanate-methyl, diethofencarb, zoxamide, pencycuron, fluoxaflufen, triflumimide, fenbutamide, fenpyrad, fluopyram, meturacilamide, meturazamide, carboxin, thiflusulfamide, furametpyr, pyraflufen, penflufen, fenpyrazofen, fenpyrazox, fenpyraclostrobin, trifloxystrobin, fenpyrad, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, fenpyrad, fenpyraclostrobin, fenchloral, fenpyrad, fenpyraclostrobin, fenpyrad, fenchloral, fenpyrad, fenchlorantraniliprol, fenpyrad, fenpyraclostrobin, fenpyrad, fenchloral, fenpyrad-p-chloride, fenpyrad, fenpyra, Triphenyl tin hydroxide, silthiopham, ametoctradin, sodium disulfate, cyprodinil, mepanipyrim, pyrimethanil, fenfluramine, kasugamycin, streptomycin, terramycin, thifluzazole and copper, zinc salts, phenoxyquinoline, propoxymidine, fenpiclonil, fludioxonil, ethiprole, iprodione, procymidone, ethephon, edifenphos, diphenphos, iprobenfos, pirophos, isoprothiolane, diclomethazine, niclosamide, pentachloronitrobenzene, tetrachloronitrobenzene, tolclofos-methyl, hymexazol, iodopropynyl butylmethylamine ester, propamocarb, thiocarb, dimethomorph, flumorph, benthiavalicarb, iprovalicarb, mandipropamid, bacillus subtilis, dodecamorpholine, fenpropimorph, tridecorph, fenpropidin, spiroxamide, fenhexamid, propyzamide, naftifine, terbinafine, validamycin, tetrachlorvinphos, mephitin, mephitrin, pyributhrix, fenpyr, fenpyrad, fenpyralid, fentebufen, terbinax, fenpyrad, fentebufen, fenpyrad, fentebufen, fenphos, fenpyrad, fenphos, fenpyrad, fenpyr, fenpyrad, fenphos, fenpropathrin, fenpyr, fenphos, fenpyr, fenpropathrin, fenpyrad, fenpyr, fenpyrad, fenflurbenflurbenfluralin, fenpyr, fenflurbenflurbenflurbenfluralin, fenfluralin, fenpyr, fenpyrad, fenpyr, fenpyrad, fenpyr, fenpyrad, fluquinazone, tricyclazole, cyprodinil, diclorocyanide, fenoxanil, acibenzolar-s, probenazole, tiadinil, isotianil, algal polysaccharide, cymoxanil, fosetyl-aluminum, phosphorous acid and salts, imidazozine, sulfsulfamide, pyridaben, sulbencarb, ethaboxam, cyflufenamid, metrafenone, dodecylguanidineacetate, mineral oil, organic oil, potassium bicarbonate, a biogenic material, copper sulfate, basic copper sulfate, cupric oxychloride, copper hydroxide, cuprous oxide, the amino acids coppicrate, sulfur, ferbam, mancozeb, maneb, metiram, propineb, thiram, zineb, thiram, captan, captafol, folpet, trifloxysulfame, mefenamate, octoguanylate, iminoctadine, trichlamide, dithianon);
insecticides (such as chlorantraniliprole, fipronil, sulfoxaflor, spinetoram, pyriproxyfen, pymetrozine, flonicamid, clofentezine, propargite, chlorfenapyr, cyromazine, pyridaben, spirotetramat, cyflumetofen, methamidophos, methyl parathion, acephate, phorate, malathion, chlorpyrifos, dimethoate, omethoate, dichlorvos, terbufos, diazinon, fenitrothion, methidathion, profenofos, quinalphos, butylpyrimidine (for soil treatment, high toxicity), fosthiazate, fenamiphos, monocrotophos, triazophos, thion, phos, phosmet, foscarnet, fluvalin, deltamethrin, lambda-cyhalothrin, cypermethrin, bifenthrin, cis-cypermethrin, S-fenvalerate, tefluthrin, cyhalothrin, fluthrin, fluvalicarb, fluvalinate, fluvalicarb, flufen, chlorpyrifos, and so, chlorpyrifos, and other, chlorpyrifos, and other, cyhalothrin, ethofenprox, permethrin, fenvalerate, cyfluthrin, fenpropathrin, diafenprox, cycloprothrin, brodifenthrin, flucythrinate, tralomethrin, gamma-cyhalothrin, proffluthrin, metofluthrin, tetrafluoroethane, mecarb, methomyl (high toxicity), carbofuran (high toxicity), aldicarb, thiodicarb, benfuracarb, carbosulfan, oxamyl, methiocarb, fenoxycarb, pirimicarb, bendiocarb, valicarb, isoprocarb, furacarb, methiocarb, ethiofencarb, propoxur, cartap, dimehypo, monosultap, thiocyclam, chlorfenapyr, nitenpyram, thiacloprid, clothianidin, abamectin, spinosad, dimethomocide, metin, metrafludwith, sumicin, methoprene, methomyl, imidacloprid, thiamethoxam, acetamiprid, nited, thiacloprid, tebufalin, tefuran, tebufalin, te, Emamectin benzoate, sulfomethacin, thiocyclam, beauveria bassiana, metarhizium, lufenuron, flufenoxuron, diflubenzuron, novaluron, flufenoxuron, chlorfluazuron, triflumuron, hexaflumuron, chlorbenzuron, chlorfluazuron, endosulfan, dicofol, lindane).
2. The synergistic composition as claimed in claim 1, wherein the mass ratio of LH-371 to active ingredient B is 80-1: 1-80;
preferably, the composition also comprises various auxiliary agents, wherein the weight percentage of the active ingredients is 1-90% of the total weight.
3. The synergistic composition as claimed in claim 1 or 2, wherein the composition is prepared as a liquid formulation or a solid formulation.
Preferably, the composition is prepared into a suspending agent, a wettable powder, a water dispersible granule, a suspending agent, an emulsion in water or a suspended seed coating agent.
4. The synergistic composition as claimed in any one of claims 1 to 3, wherein the composition comprises at least one surfactant;
preferably, the content of the surfactant is 2-30% of the total weight of the preparation, and the balance is solid or liquid diluent.
Preferably, the surfactant is selected from one or more of a dispersing agent, a wetting agent, a thickening agent or a defoaming agent.
Preferably, the preparation also contains auxiliary agents such as a stabilizer, an antifreeze agent and the like.
5. The synergistic composition as claimed in any one of claims 1 to 4, wherein the composition comprises the following components in amounts when prepared into a wettable powder: LH-3711-80%, active component B1-80%, dispersant 1-12%, wetting agent 1-8%, and filler in balance,
preferably, the composition comprises the following components in percentage by weight when being prepared into water dispersible granules: LH-3711-80%, active component B1-80%, dispersant 1-12%, wetting agent 1-8%, disintegrating agent 1-10%, binder 1-8%, and filler in balance,
preferably, the composition is prepared into a suspending agent and comprises the following components in percentage by weight: LH-3711-50%, active component B1-50%, dispersant 1-12%, wetting agent 1-10%, thickening agent 0.1-2%, antifreeze agent 0.1-8%, deionized water to 100%,
preferably, the composition comprises the following components and contents when being prepared into an aqueous emulsion: LH-3711-50%, active component B1-50%, organic or inorganic solvent 1-20%, emulsifier 1-12%, optionally antifreeze agent 0.1-8%, defoaming agent 0.01-2%, thickener 0.1-2%, deionized water to make up to 100%,
preferably, the composition is prepared into a suspended seed coating (FS) and comprises the following components in percentage by weight: LH-3711-50%, active component B1-50%, dispersing agent 2-10%, anti-freezing agent 0.1-5%, anti-caking agent 0.1-10%, suspending agent 0.1-5%, film-forming agent 1-10%, preservative 0.1-5%, coloring agent 0.1-5%, pH regulator 0.1-5%, and deionized water to make up to 100%.
6. The synergistic composition according to any one of claims 1 to 5, wherein the emulsifier is selected from one of the following: one or more of sodium dodecyl sulfate, calcium dodecyl benzene sulfonate, sodium lignosulfonate, agricultural emulsion, sodium dodecyl benzene sulfonate, calcium dodecyl benzene sulfonate, phenyl phenol polyoxyethylene ether phosphate, naphthalene sulfonate formaldehyde condensate, benzyl dimethyl phenol polyoxyethylene ether, styryl phenyl polyoxyethylene ether, phenethyl phenol polyoxyethylene polyoxypropylene ether, sorbitan monostearate polyoxyethylene ether, span-80, sorbitan fatty acid ester polyoxyethylene ether, tween-20, fatty alcohol polyoxyethylene ether, NP-10, nonylphenol polyoxyethylene ether phosphate and castor oil polyoxyethylene ether phosphate.
7. The synergistic composition as claimed in any one of claims 1 to 6, wherein the dispersant is selected from the group consisting of: one or more of glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, sodium lignosulfonate, fatty alcohol polyoxyethylene ether sulfate, naphthalene sulfonate formaldehyde condensate sodium salt, nonylphenol polyoxyethylene ether, polyoxyethylene lanolin alcohol, alkylphenol polyoxyethylene ether formaldehyde condensate, fatty alcohol polyoxyethylene ether phosphate and polyoxyethylene sorbitan fatty acid ester;
preferably, the wetting agents are selected from: one or more of trisiloxane polyoxyethylene ether, N-lauroyl sodium glutamate, sodium dodecyl sulfate, sodium lauroyl sarcosinate, castor oil polyoxyethylene ether, triphenyl ethylphenol polyoxyethylene ether, calcium dodecyl benzene sulfonate, isooctyl alcohol succinic acid sodium acetate sulfonate, fatty alcohol polyoxyethylene ether, alkyl naphthalene sodium sulfonate, methyl naphthalene sodium sulfonate formaldehyde condensate and lauryl sodium sulfate;
preferably, the adhesive is selected from: one or more of xanthan gum, starch, gelatin, arabic gum, carboxymethyl cellulose and carboxyethyl cellulose;
preferably, the disintegrating agent is selected from: one or more of sodium bicarbonate, ammonium sulfate, sulfuric acid, sodium sulfate, calcium sulfate and magnesium chloride;
preferably, the thickening agent is selected from: one or more of magnesium aluminum silicate, polyvinyl acetate, xanthan gum, gelatin, arabic gum, polyvinyl alcohol and bentonite;
preferably, the defoaming agent is selected from: one or more of n-octanol, silicone, butyl phosphate vinegar and isobutyl phosphate vinegar;
preferably, the antifreeze agent is selected from: one or more selected from propylene glycol, ethylene glycol, glycerol, etc.;
preferably, the stabilizer is selected from: one or more of epichlorohydrin, butyl glycidyl ether, triphenyl phosphite, N-soybean oil-based trimethylene diamine, dialkyl succinic acid acetate sulfonate and the like;
preferably, the filler and/or carrier comprises a solid filler and/or carrier and a liquid filler and/or carrier;
preferably, the solid filler and/or the carrier can be selected from: one or more of kaolin, attapulgite, diatomite, white carbon black, bentonite, montmorillonite and calcium carbonate. The liquid filler and/or carrier may be selected from one or more of water, soybean oil, castor oil, mineral oil;
preferably, the organic solvent is selected from: one or more of ethyl acetate, acetone, isopropanol, benzene, toluene, xylene, dimethylformamide, dimethyl sulfoxide, dichloromethane, cyclohexane, cyclohexanone, N-methylpyrrolidone.
8. The synergistic composition as claimed in any one of claims 1 to 7, wherein the formulation is in the form of suspension, aqueous emulsion, water dispersible granule, microcapsule suspension-suspension, dispersible liquid, microemulsion, wettable powder, suspoemulsion, emulsifiable concentrate, suspended seed coating, seed treatment emulsion, seed treatment liquid, granule, hot fogging concentrate.
9. A process for the preparation of the synergistic composition as claimed in any one of claims 1 to 7, which comprises: mixing active ingredient LH-371 and active ingredient B with adjuvant.
10. Use of the synergistic composition according to any one of claims 1 to 7 for controlling plant diseases and insect pests such as downy mildew of melons, target spot of cucumber, gray mold of tomato, late blight of potato, powdery mildew of cucumber, anthracnose of cucumber, scab of melon, rice blast, scab of wheat, rust of wheat, powdery mildew of wheat, wheat sharp leaf blight of wheat, rice sheath blight of rice, rust of soybean, rust of corn, rust of garlic, black nevus of potato, southern blight of peanut, sclerotinia rot of rape, brown rot of peach, brown spot of peanut, citrus scab, white fly, aphids (such as wheat), thrips, grub, green plant bug, rice leaf roller, bean pod borer, diamond back moth, beet armyworm, noctuid and the like.
CN202010881665.3A 2020-08-26 2020-08-26 Synergistic composition containing pyrazole amide compounds Pending CN114097794A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109928929A (en) * 2017-12-15 2019-06-25 华中师范大学 Pyrazol acid amide compounds and its application and fungicide

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109928929A (en) * 2017-12-15 2019-06-25 华中师范大学 Pyrazol acid amide compounds and its application and fungicide

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Title
陕西省种子管理站: "农作物主要病害诊断与防治", 黑龙江大学出版社 *

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