CN114057816A - 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 - Google Patents
富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 Download PDFInfo
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- 238000012546 transfer Methods 0.000 description 1
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- 201000001862 viral hepatitis Diseases 0.000 description 1
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010753174.0A CN114057816A (zh) | 2020-07-30 | 2020-07-30 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
| PCT/CN2021/101064 WO2022022158A1 (fr) | 2020-07-30 | 2021-06-18 | Oligonucléotide de phosphorothioate riche en adénine et son application anti-virus de l'hépatite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010753174.0A CN114057816A (zh) | 2020-07-30 | 2020-07-30 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
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| Publication Number | Publication Date |
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| CN114057816A true CN114057816A (zh) | 2022-02-18 |
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| CN202010753174.0A Pending CN114057816A (zh) | 2020-07-30 | 2020-07-30 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
Country Status (2)
| Country | Link |
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| CN (1) | CN114057816A (fr) |
| WO (1) | WO2022022158A1 (fr) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084232A (zh) * | 2004-10-19 | 2007-12-05 | 里普利科股份有限公司 | 抗病毒寡核苷酸 |
| WO2008139262A2 (fr) * | 2006-10-26 | 2008-11-20 | Coley Pharmaceutical Gmbh | Oligoribonucléotides et leurs utilisations |
| WO2013039855A1 (fr) * | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Composés et compositions pharmaceutiques pour le traitement d'infections virales |
| WO2014179446A2 (fr) * | 2013-05-01 | 2014-11-06 | Regulus Therapeutics Inc. | Composés microarn et procédés permettant la modulation de l'activité de mir-122 |
| CN105061534A (zh) * | 2010-09-22 | 2015-11-18 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
| CN106659730A (zh) * | 2014-07-10 | 2017-05-10 | 里普利科股份有限公司 | 治疗b型肝炎和d型肝炎病毒感染的方法 |
| WO2018053185A1 (fr) * | 2016-09-14 | 2018-03-22 | Alios Biopharma, Inc. | Oligonucléotides modifiés et méthodes d'utilisation |
-
2020
- 2020-07-30 CN CN202010753174.0A patent/CN114057816A/zh active Pending
-
2021
- 2021-06-18 WO PCT/CN2021/101064 patent/WO2022022158A1/fr active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084232A (zh) * | 2004-10-19 | 2007-12-05 | 里普利科股份有限公司 | 抗病毒寡核苷酸 |
| WO2008139262A2 (fr) * | 2006-10-26 | 2008-11-20 | Coley Pharmaceutical Gmbh | Oligoribonucléotides et leurs utilisations |
| CN105061534A (zh) * | 2010-09-22 | 2015-11-18 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
| WO2013039855A1 (fr) * | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Composés et compositions pharmaceutiques pour le traitement d'infections virales |
| WO2014179446A2 (fr) * | 2013-05-01 | 2014-11-06 | Regulus Therapeutics Inc. | Composés microarn et procédés permettant la modulation de l'activité de mir-122 |
| CN106659730A (zh) * | 2014-07-10 | 2017-05-10 | 里普利科股份有限公司 | 治疗b型肝炎和d型肝炎病毒感染的方法 |
| WO2018053185A1 (fr) * | 2016-09-14 | 2018-03-22 | Alios Biopharma, Inc. | Oligonucléotides modifiés et méthodes d'utilisation |
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| Publication number | Publication date |
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| WO2022022158A1 (fr) | 2022-02-03 |
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