CN114052246B - Antioxidant composition containing quercetin and gallic acid - Google Patents
Antioxidant composition containing quercetin and gallic acid Download PDFInfo
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- CN114052246B CN114052246B CN202010781899.0A CN202010781899A CN114052246B CN 114052246 B CN114052246 B CN 114052246B CN 202010781899 A CN202010781899 A CN 202010781899A CN 114052246 B CN114052246 B CN 114052246B
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- gallic acid
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- quercetin
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- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 title claims abstract description 94
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229940074391 gallic acid Drugs 0.000 title claims abstract description 46
- 235000004515 gallic acid Nutrition 0.000 title claims abstract description 46
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 42
- 235000006708 antioxidants Nutrition 0.000 title claims abstract description 42
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 37
- 235000005875 quercetin Nutrition 0.000 title claims abstract description 36
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 title claims abstract description 23
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 title claims abstract description 23
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 229960001285 quercetin Drugs 0.000 title claims abstract description 23
- 235000013305 food Nutrition 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 14
- 239000000654 additive Substances 0.000 claims description 13
- 230000000996 additive effect Effects 0.000 claims description 12
- 238000007254 oxidation reaction Methods 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 11
- 238000009472 formulation Methods 0.000 claims description 10
- 230000003647 oxidation Effects 0.000 claims description 10
- 229940088594 vitamin Drugs 0.000 claims description 8
- 239000011782 vitamin Substances 0.000 claims description 8
- 229930003231 vitamin Natural products 0.000 claims description 8
- 235000013343 vitamin Nutrition 0.000 claims description 8
- 235000021466 carotenoid Nutrition 0.000 claims description 7
- 150000001747 carotenoids Chemical class 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 6
- -1 gallate ester Chemical class 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 3
- 229930182470 glycoside Natural products 0.000 claims description 3
- 239000002738 chelating agent Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000019198 oils Nutrition 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000000979 retarding effect Effects 0.000 claims 3
- 239000002417 nutraceutical Substances 0.000 claims 2
- 235000021436 nutraceutical agent Nutrition 0.000 claims 2
- 239000003925 fat Substances 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 235000005881 Calendula officinalis Nutrition 0.000 description 12
- 241000736851 Tagetes Species 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 4
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 3
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 235000019764 Soybean Meal Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 239000004455 soybean meal Substances 0.000 description 2
- AZJQQNWSSLCLJN-UHFFFAOYSA-N 2-ethoxyquinoline Chemical compound C1=CC=CC2=NC(OCC)=CC=C21 AZJQQNWSSLCLJN-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
Abstract
An antioxidant composition comprises quercetin and gallic acid component, wherein the gallic acid component is gallic acid and/or its derivative. The quercetin and the gallic acid are compounded according to a proper proportion for use, so that the anti-oxidation effect can be obviously improved, and the stability of products such as food, feed, medicines and the like can be ensured.
Description
Technical Field
The invention belongs to the field of additives, and particularly relates to an antioxidant composition containing quercetin and gallic acid and application thereof.
Background
In the process of placing foods, feeds, medicines and the like, effective components such as grease, vitamins, carotenoid and the like in the foods, feeds, medicines and the like can undergo oxidation reaction, so that the content of the effective components is reduced, and the quality of products is seriously influenced. Wherein the fat can cause deterioration of fat and generate peculiar smell. Carotenoids are the main source of vitamin a in vivo, and also have antioxidant, immunomodulating, anticancer, antiaging effects. Because the molecular structure contains a large number of double bonds, the oxidation reaction is extremely easy to occur and the loss is caused. Vitamins are a class of trace organic substances that humans and animals must obtain from food in order to maintain normal physiological functions, playing an important role in the growth, metabolism, and development of the human body. Most of vitamins such as VA and VC are easy to oxidize and deteriorate in the process of placing, so that the content is lost.
In order to prevent the oxidation loss of the active ingredient, the addition of an antioxidant is a method generally used at present. Antioxidants on the market are mainly chemically synthesized, such as TBHQ (tert-butylhydroquinone), BHA (butylhydroxyanisole), BHT (dibutylhydroxytoluene), EQ (ethoxyquinoline), etc. EQ is one of feed antioxidants with excellent performance, and is the antioxidant with highest cost performance. TBHQ, BHA, BHT and the like can be applied to the fields of food and the like besides being applied to feeds. Synthetic antioxidants such as EQ, BHT and the like have low cost, but have safety problems with different degrees generally, and the application of products is limited to a certain extent.
The quercetin has the chemical name of 3,3,4,5,6,7-hexahydroxy flavone, has important pharmacological actions of antioxidation, anti-inflammation, antiallergic, anti-tumor and the like, and has good antioxidation effect.
Gallic acid is a polyphenol compound existing in nature and has wide application in the fields of food, biology, medicine, chemical industry and the like. In addition, gallic acid is often present in its derivative form, which mainly includes gallates, and gallic acid glycosides.
When in use, different antioxidants are reasonably matched for use, and a synergistic effect is sometimes achieved. The application finds that the quercitin and the gallic acid component are compounded according to a certain proportion for use, has obvious synergistic effect, can effectively delay the oxidation process of the effective components of the product, and ensures the stability of the quality of the product.
Disclosure of Invention
In order to further improve the antioxidation effect and the safety of the antioxidation additive, the invention provides the antioxidation composition containing the quercitin and the gallic acid component, and the antioxidation effect can be improved by compounding the quercitin and the gallic acid component.
The technical scheme adopted for solving the technical problems is as follows: an antioxidant composition contains quercetin and gallic acid.
The application further provides an antioxidant composition, wherein the weight ratio of the quercitin to the gallic acid component in the composition is 300:1-70:1; may preferably be 200:1 to 80:1; it may be further preferred that 150:1 to 100:1.
Still further, the weight ratio of quercetin and gallic acid components may be 150:1, 149:1, 148:1, 147:1, 146:1, 145:1, 144:1, 143:1, 142:1, 141:1, 140:1, 139: 1. 138:1, 137:1, 136:1, 135:1, 134:1, 133:1, 132:1, 131:1, 130:1, 129:1, 128:1, 127:1, 126:1, 125:1, 124:1, 123:1, 122:1, 121:1, 120:1, 119:1, 118:1, 117:1, 116:1, 115:1, 114:1, 113:1, 112:1, 111:1, 110: 1. 109:1, 108:1, 107:1, 106:1, 105:1, 104:1, 103:1, 102:1, 101:1, 100:1, 99:1, 98:1, 97:1, 96:1, 95:1, 94:1, 93:1, 92:1, 91:1, 90:1, 89:1, 88:1, 87:1, 86:1, 85:1, 84:1, 83:1, 82:1, 81:1, 80:1, 79:1, 78:1, 76:1, 75:1, 74:1, 73:1, 72:1, 71:1, or 70:1.
Further, the gallic acid component is gallic acid and/or its derivative; preferably, the gallic acid derivative is any one or more of gallate, gallate or gallic acid glycoside.
Further, the antioxidant composition further comprises one or more components such as an adaptive carrier, a metal ion chelating agent, an emulsifying agent and the like.
The antioxidant composition can be used as additive, and added into food, feed, nutritional health product or medicine to ensure product quality stability.
The antioxidant composition can be used as an additive, can effectively delay the oxidation process of each component in foods, feeds, cosmetics, nutritional health products or medicines, and ensures the stability of the quality of the products.
The antioxidant composition can effectively delay oxidation process of oil, vitamins, carotenoid and other components, and ensure stability of the components.
The present application also provides an additive formulation, i.e., the composition is formulated according to conventional methods to any acceptable suitable formulation, preferably, as a powder, liquid or microcapsule.
The additive preparation can effectively delay the oxidation process of components such as grease, vitamins, carotenoid and the like, and ensure the stability of the components.
The additive preparation can be added into food, feed, cosmetics, nutritional health product, and medicine to ensure product quality stability.
The beneficial effects of the invention are as follows:
the inventor discovers that when the quercitin and the gallic acid component are compounded according to a certain proportion for use, the composition containing the quercitin and the gallic acid component according to a certain proportion has obvious synergistic effect, and under the same additive amount, the protection effect of the composition on grease, vitamins, carotenoid and the like in foods, feeds, cosmetics, nutritional health care products or medicines is obviously better than that of the composition containing the quercitin and the gallic acid component which is singly used, and the oxidation process of each component in the foods, feeds, cosmetics, nutritional health care products or medicines can be delayed, so that the stability of the products in the storage process is ensured.
The quercitin and gallic acid components are natural products widely existing in plants, and the product safety is superior to that of the conventional synthetic antioxidants. The natural flavone and polyphenol components not only can delay the oxidation of the product, but also can play roles in scavenging free radicals, resisting inflammation, resisting tumors and the like in human and animal bodies, and are beneficial to the health of human and animals.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Example 1
The antioxidant composition of example 1 was prepared by mixing the following raw materials in proportions: 150g of quercetin marigold with the content of 80% and 1g of gallic acid with the content of 80% are mixed to obtain 151g of composition, wherein the weight ratio of the quercetin marigold to the gallic acid in the composition is 150:1.
Example 2
The antioxidant composition of example 2 was prepared by mixing the following raw materials in proportions: 300g of quercetin marigold with the content of 80%, 1g of gallic acid with the content of 80% and 100g of carrier silicon dioxide are mixed to obtain 401g of composition, wherein the weight ratio of the quercetin marigold to the gallic acid in the composition is 300:1.
Example 3
The antioxidant composition of example 3 was prepared by mixing the following raw materials in proportions: 70g of quercetin marigold with the content of 80%, 1g of gallic acid with the content of 80% and 30g of carrier silicon dioxide are mixed to obtain 101g of composition, wherein the weight ratio of the quercetin marigold to the gallic acid in the composition is 70:1.
Example 4
The antioxidant composition of example 1 was prepared by mixing the following raw materials in proportions: 100g of quercetin marigold with the content of 80% and 1g of gallic acid with the content of 80% are mixed to obtain 101g of composition, wherein the weight ratio of the quercetin marigold to the gallic acid in the composition is 100:1.
Comparative example 1
80% of quercetin.
Comparative example 2
Gallic acid with 80% content.
Comparative example 3
The following raw materials were mixed in proportion to prepare an antioxidant composition of comparative example 3: 50g of quercetin marigold with the content of 80% and 1g of gallic acid with the content of 80% are mixed to obtain 51g of composition, wherein the weight ratio of the quercetin marigold to the gallic acid in the composition is 50:1.
Comparative example 4
The following raw materials were mixed in proportion to prepare an antioxidant composition of comparative example 4: 500g of quercetin marigold with the content of 80%, 1g of gallic acid with the content of 80% and 100g of carrier silicon dioxide are mixed to obtain 601g of composition, wherein the weight ratio of the quercetin marigold to the gallic acid in the composition is 500:1.
Taking feed as an example, the antioxidation effect evaluation is carried out:
1. sample preparation:
(1) Pulverizing soybean meal for later use;
(2) Self-made premix formula (CuSO) 4 40％+FeSO 4 30％+MnSO 4 20％+Zn SO 4 10%) and equal amount of SiO 2 Fully and uniformly mixing by using a pulverizer;
(3) Feed (92% of soybean meal + 1% of premix compound + 7% of soybean oil) was prepared, and antioxidants of examples 1-4 and comparative examples 1-4 were added, respectively, to prepare 8 groups of samples having antioxidant amounts of 300ppm each, wherein the antioxidant amounts were calculated as the total content of antioxidant active ingredients. A blank control group was additionally set. Each group is repeated three times, and each sample is placed in a beaker in an open mode after being uniformly mixed;
2. evaluation index: peroxide value
3. Storage and detection conditions: the samples of each group were placed in a stability test chamber at 50℃and 70% humidity for 5 days.
The peroxide value in each sample was measured after 5 days of standing under the above storage conditions. The detection is carried out according to the method of GB5009.227-2016 determination of peroxide value in food safety national standard food.
The results are shown in Table 1.
Table 1 results of measurement of peroxide values of feeds to which different antioxidant compositions were added
The results in Table 1 show that under the same dosage conditions, the antioxidant effect of the composition of the quercitin and the gallic acid according to the specific proportion described in the application is better than that of the composition of the quercitin and the gallic acid which are used singly, and is also better than that of the composition of the quercitin and the gallic acid which are mixed in other proportions.
Claims (12)
1. An antioxidant composition is characterized by comprising an antioxidant component, wherein the antioxidant component is a quercitin and gallic acid component, and the weight ratio of the quercitin to the gallic acid component is 300:1-70:1.
2. The antioxidant composition of claim 1, wherein the weight ratio of quercetin and gallic acid components in the composition is 200:1-80:1.
3. The antioxidant composition of claim 2, wherein the weight ratio of quercetin and gallic acid components in the composition is 150:1-100:1.
4. An antioxidant composition according to any one of claims 1 to 3, wherein the gallic acid component is gallic acid and/or a derivative thereof.
5. The antioxidant composition of claim 4, wherein the gallic acid derivative is one or more of gallate, gallate ester, and gallic acid glycoside.
6. An antioxidant composition as claimed in any one of claims 1 to 3, further comprising one or more of an adapted carrier, a metal ion chelating agent, an emulsifier.
7. An additive formulation comprising the antioxidant composition of any one of claims 1-6 and prepared according to any one of the conventional formulation methods.
8. An additive formulation as claimed in claim 7 wherein said formulation is prepared as a powder, liquid or microcapsule.
9. Use of an antioxidant composition according to any one of claims 1-6, characterized in that the antioxidant composition is added as an additive to food, feed, cosmetics, nutraceuticals, pharmaceuticals to ensure the stability of the product.
10. Use of an antioxidant composition according to any one of claims 1-6, characterized in that the antioxidant composition is used for retarding the oxidation process of oils, vitamins, carotenoids.
11. Use of an additive formulation according to any one of claims 7-8, wherein the formulation is used for retarding the oxidation process of active ingredients in foods, feeds, cosmetics, nutraceuticals, pharmaceuticals.
12. Use of an additive formulation according to any one of claims 7-8, characterized in that the formulation is used for retarding the oxidation process of fats, vitamins, carotenoids.
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| CN105541775A (en) * | 2016-02-26 | 2016-05-04 | 中国农业大学 | Industrial preparation method of quercetagetin |
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| CN110776449A (en) * | 2019-10-22 | 2020-02-11 | 晨光生物科技集团股份有限公司 | Industrial method for extracting lutein and quercetagetin |
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| JP2008156278A (en) * | 2006-12-22 | 2008-07-10 | Takasago Internatl Corp | Two-pack type antioxidant composition and antioxidant product containing the same |
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| MX2018003120A (en) * | 2018-03-13 | 2018-09-28 | Univ Tecnologica De La Mixteca | Cream for improving skin with wrinkles. |
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