CN114018783A - Menses simulating liquid for women - Google Patents
Menses simulating liquid for women Download PDFInfo
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- CN114018783A CN114018783A CN202111304718.6A CN202111304718A CN114018783A CN 114018783 A CN114018783 A CN 114018783A CN 202111304718 A CN202111304718 A CN 202111304718A CN 114018783 A CN114018783 A CN 114018783A
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- menstrual blood
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- 239000007788 liquid Substances 0.000 title claims abstract description 73
- 210000004914 menses Anatomy 0.000 title description 5
- 239000008280 blood Substances 0.000 claims abstract description 56
- 210000004369 blood Anatomy 0.000 claims abstract description 56
- 230000002175 menstrual effect Effects 0.000 claims abstract description 39
- 238000004088 simulation Methods 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000003607 modifier Substances 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 159000000000 sodium salts Chemical class 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 181
- 239000000243 solution Substances 0.000 claims description 68
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 38
- 238000002156 mixing Methods 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 21
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
- 235000013336 milk Nutrition 0.000 claims description 16
- 239000008267 milk Substances 0.000 claims description 16
- 210000004080 milk Anatomy 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 239000011521 glass Substances 0.000 claims description 12
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 9
- 239000004310 lactic acid Substances 0.000 claims description 9
- 235000014655 lactic acid Nutrition 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 8
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 7
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 7
- 244000068988 Glycine max Species 0.000 claims description 7
- 235000010469 Glycine max Nutrition 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- 239000005639 Lauric acid Substances 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- 229930195729 fatty acid Natural products 0.000 claims description 5
- 150000004665 fatty acids Chemical class 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 239000001509 sodium citrate Substances 0.000 claims description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 239000001054 red pigment Substances 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 229920000084 Gum arabic Polymers 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000000205 acacia gum Substances 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 11
- 239000011347 resin Substances 0.000 abstract description 8
- 229920005989 resin Polymers 0.000 abstract description 8
- 238000012360 testing method Methods 0.000 abstract description 7
- 241001465754 Metazoa Species 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 238000005054 agglomeration Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- -1 simulation regulator Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 14
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 12
- 238000000034 method Methods 0.000 description 6
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 description 6
- 239000012086 standard solution Substances 0.000 description 5
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940033355 lauric acid Drugs 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000013322 soy milk Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N13/04—Investigating osmotic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/44—Resins; Plastics; Rubber; Leather
- G01N33/442—Resins; Plastics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the technical field of blood simulation liquid, and particularly relates to woman menstrual blood simulation liquid. The woman menstrual blood simulating liquid is prepared from the following raw materials: tertiary water, inorganic sodium salt, acid-base regulator, thickener, simulation modifier, simulation regulator, preservative and haematochrome. The woman menstrual blood simulation liquid has a scientific and reasonable formula, is added with the simulation modifier, is matched with other components in the simulation liquid, obtains a product which is more excellent than the existing standard test liquid, is closer to the physical characteristics of human blood compared with the existing standard liquid, has the advantages of difficult agglomeration, easy storage, lower price and the like compared with human and animal blood materials, and has good guiding significance on the measurement of absorption and permeability of sanitary towels and high-absorption resin.
Description
The application is a divisional application with the application number of 201710134444.8, the application date of 2017, 3 and 8, and the invention name of the divisional application is female menstrual blood simulant and the preparation method of the female menstrual blood simulant.
Technical Field
The invention belongs to the technical field of blood simulation liquid, and particularly relates to woman menstrual blood simulation liquid.
Background
In recent years, the high-absorption resin material for sanitary towels has been produced through the technical development of the raw material high-molecular absorption resin for sanitary products. In the past, the permeation and absorption performances of the sanitary napkins and the absorbent materials for the sanitary napkins are generally detected by adopting normal saline and distilled water, but the physical performances of real menstrual blood, distilled water and normal saline of women have larger difference, and along with the continuous improvement and promotion of the detection method, the requirement of the permeation and absorption performance test cannot be met by adopting normal saline and distilled water alone, and the blood absorption performance of the absorbent materials for the sanitary napkins and the sanitary products cannot be reflected; later, people buy real human blood or use animal blood for detection, but the real human blood and the real animal blood are not easy to obtain, are high in price, are easy to agglomerate and are not easy to store.
At present, the formula of a blood simulated liquid, namely a standard liquid, adopted for detecting the high-absorptivity resin for the sanitary products and the sanitary towels for women is listed in the national standard of the high-absorptivity resin of the sanitary towels, but through research, the pH value of the standard liquid is about 4 higher than the pH value of real menstrual blood of women, the viscosity of the standard liquid is about 7 higher than the real blood, and the pH value of the standard liquid cannot be well close to the value of a blood test product when the product is detected, so the test result obtained by adopting the solution cannot well reflect the blood absorption characteristic of the sanitary products, the inaccurate test result also causes the unstable absorption performance of the sanitary products and the high-absorptivity resin products, and certain influence is generated on the production of materials of upstream products and the quality of downstream products.
Disclosure of Invention
The invention is realized by the following technical scheme: a woman menstrual blood simulation liquid is prepared from the following raw materials in parts by weight:
950 portions of tertiary water 820-containing materials, 40-50 portions of inorganic sodium salt, 9-12 portions of acid-base regulator, 1-3 portions of thickening agent, 75-90 portions of simulation modifier, 0.05-0.3 portion of simulation regulator, 0.5-1.5 portions of preservative and 2-3 portions of red pigment.
The woman menstrual blood simulation liquid is prepared from the following raw materials in parts by weight:
859.35 parts of tertiary water, 45 parts of inorganic sodium salt, 10 parts of acid-base regulator, 2 parts of thickener, 80 parts of simulation modifier, 0.15 part of simulation regulator, 1 part of preservative and 2.5 parts of red pigment.
The acid-base regulator is two or more of citric acid, phosphoric acid, sodium hydroxide, potassium carbonate, sodium citrate and potassium dihydrogen phosphate.
The thickener is one or more of glycerol, sodium carboxymethylcellulose, gelatin, polyvinyl alcohol and gum arabic.
The simulation modifier is protein powder, soybean milk powder or milk powder.
The simulation regulator is one or more of fatty acid shanli tan, lauric acid, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate and glycerin monostearate.
The preservative is lactic acid or sodium benzoate.
The inorganic sodium salt is sodium sulfate or sodium chloride.
The preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. pouring the inorganic sodium salt, the acid-base regulator, the thickening agent, the simulation regulator and the preservative in parts by weight into a beaker, and stirring and mixing uniformly;
b. slowly pouring the three-stage water in parts by weight into the beaker, and stirring with a glass rod while pouring; then placing the beaker on a magnetic stirrer, and stirring for 15min to obtain a stirring liquid A;
c. pouring 300mL of 200-300mL of stirring liquid A each time, placing the stirring liquid A on a stirrer, stirring for 4-8min, and mixing the liquid obtained after each stirring to obtain stirring liquid B;
d. pouring 300mL of 200-300mL of stirring liquid B in each time, placing the stirring liquid B on a stirrer, stirring for 4-8min, and mixing the liquid stirred in each time to obtain stirring liquid C;
e. pouring 200-300mL of the stirring liquid C in each time, placing the stirring liquid C on a stirrer, stirring for 4-8min, and mixing the liquid obtained after each stirring to obtain stirring liquid D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the simulation modifier in parts by weight into the filtrate obtained in the step f, stirring until the simulation modifier is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min to obtain a stirring solution E;
h. and adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for not less than 36 hours to obtain the haematochrome.
The stirring speed of the magnetic stirrer is 600-900 r/min; the stirring speed of the stirrer is 9000-.
The invention has the beneficial effects that:
1. the woman menstrual blood simulation liquid has a scientific and reasonable formula, is added with the simulation modifier, is matched with other components such as inorganic sodium salt, an acid-base regulator, a thickening agent, a simulation regulator, haematochrome and the like in the simulation liquid, is stirred fully and repeatedly to obtain a product which is more excellent than the existing standard test liquid, has a good guiding significance on the determination of the absorption and permeability performances of sanitary towels and high-absorptivity resin, and can be used for improving and improving upstream and downstream products according to the determination result, so that the high quality and the stable quality of the product are ensured.
2. The preparation method of the woman menstrual blood simulation fluid is simple and has strong operability, the prepared woman menstrual blood simulation fluid has the pH value of 7.20 +/-0.5 at room temperature, the viscosity of 7.0 +/-0.8 mPa & s, the density of 1.06 +/-0.05 g/cm2 and the surface tension of 40 +/-4 mN/m, is closer to the physical characteristics of human blood compared with the existing standard fluid, has the advantages of difficult caking, easy storage, lower price and the like compared with human and animal blood materials, and has good practical value and economic benefit.
Detailed Description
The present invention will be further described with reference to the following examples, but the present invention is not limited thereto.
Example 1:
the woman menstrual blood simulating liquid is prepared from the following raw materials in parts by weight:
859.35g of tertiary water, 45g of sodium chloride, 3g of sodium carbonate, 7g of monopotassium phosphate, 2g of glycerol, 80g of protein powder, 0.15g of sodium dodecyl benzene sulfonate, 1g of sodium benzoate and 2.5g of haematochrome.
The preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. pouring the sodium chloride, the sodium carbonate, the monopotassium phosphate, the glycerol, the sodium dodecyl benzene sulfonate and the sodium benzoate into a beaker, and stirring and mixing the materials uniformly by using a glass rod;
b. taking the three-stage water with the weight, slowly pouring the three-stage water into the beaker, and stirring the three-stage water with a glass rod while pouring the three-stage water; then placing the beaker on a magnetic stirrer, and stirring for 15min at the stirring speed of 800r/min to obtain a solution A;
c. pouring 250mL of the stirring solution A in each time, placing the stirring solution A on a small-sized stirrer, stirring for 5min under the condition of a stirring rotation speed of 10000r/min, and mixing the liquid stirred in each time to obtain a stirring solution B;
d. pouring 250mL of the stirring solution B in each time, placing the stirring solution B on a small-sized stirrer, stirring for 5min under the condition of a stirring rotating speed of 10000r/min, and mixing the liquid stirred in each time to obtain a stirring solution C;
e. pouring 250mL of the stirring solution C in each time, placing the stirring solution C on a small-sized stirrer, stirring for 5min under the condition of a stirring rotation speed of 10000r/min, and mixing the liquid stirred in each time to obtain a stirring solution D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the protein powder in parts by weight into the filtrate obtained in the step f, stirring until the protein powder is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min at a stirring speed of 800r/min to obtain a stirring solution E;
h. and adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for 38 hours to obtain the haematochrome.
Example 2:
the woman menstrual blood simulating liquid is prepared from the following raw materials in parts by weight:
820g of tertiary water, 40g of sodium sulfate, 2g of sodium carbonate, 7g of monopotassium phosphate, 1g of glycerol, 75g of milk powder, 0.05g of sodium dodecyl benzene sulfonate, 0.5g of lactic acid and 2g of haematochrome.
The preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. pouring the sodium sulfate, the sodium carbonate, the monopotassium phosphate, the glycerol, the sodium dodecyl benzene sulfonate and the lactic acid into a beaker, and stirring and mixing the materials uniformly by using a glass rod;
b. taking the three-stage water with the weight, slowly pouring the three-stage water into the beaker, and stirring the three-stage water with a glass rod while pouring the three-stage water; then placing the beaker on a magnetic stirrer, and stirring for 15min at a stirring speed of 600r/min to obtain a solution A;
c. pouring 200mL of the stirring solution A in each time, placing the stirring solution A on a small-sized stirrer, stirring for 4min at a stirring speed of 9000r/min, and mixing the liquid stirred in each time to obtain a stirring solution B;
d. pouring 200mL of the stirring solution B in each time, placing the stirring solution B on a small-sized stirrer, stirring for 4min at a stirring speed of 9000r/min, and mixing the liquid stirred in each time to obtain a stirring solution C;
e. pouring 200mL of the stirring solution C in each time, placing the stirring solution C on a small-sized stirrer, stirring for 4min at a stirring speed of 9000r/min, and mixing the liquid stirred in each time to obtain a stirring solution D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the soybean milk powder in parts by weight into the filtrate obtained in the step f, stirring until the soybean milk powder is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min at a stirring speed of 600r/min to obtain a stirring solution E;
h. and adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for 40 hours to obtain the haematochrome.
Example 3:
the woman menstrual blood simulating liquid is prepared from the following raw materials in parts by weight:
840.2g of tertiary water, 50g of sodium chloride, 5g of sodium carbonate, 7g of monopotassium phosphate, 3g of glycerol, 90g of soymilk powder, 0.3g of sodium dodecyl benzene sulfonate, 1.5g of sodium benzoate and 3g of haematochrome.
The preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. pouring the sodium chloride, the sodium carbonate, the monopotassium phosphate, the glycerol, the sodium dodecyl benzene sulfonate and the sodium benzoate into a beaker, and stirring and mixing the materials uniformly by using a glass rod;
b. taking the three-stage water with the weight, slowly pouring the three-stage water into the beaker, and stirring the three-stage water with a glass rod while pouring the three-stage water; then placing the beaker on a magnetic stirrer, and stirring for 15min at the stirring speed of 900r/min to obtain a solution A;
c. pouring 300mL of the stirring solution A in each time, placing the stirring solution A on a small-sized stirrer, stirring for 8min under the stirring rotating speed of 9000r/min, and mixing the liquid stirred in each time to obtain a stirring solution B;
d. pouring 300mL of the stirring solution B in each time, placing the stirring solution B on a small-sized stirrer, stirring for 8min under the stirring rotating speed of 9000r/min, and mixing the liquid stirred in each time to obtain a stirring solution C;
e. pouring 300mL of the stirring solution C in each time, placing the stirring solution C on a small-sized stirrer, stirring for 8min under the stirring rotating speed of 9000r/min, and mixing the liquid stirred in each time to obtain a stirring solution D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the milk powder in parts by weight into the filtrate obtained in the step f, stirring until the milk powder is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min at the stirring speed of 900r/min to obtain a stirring solution E;
h. and adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for 45 hours to obtain the haematochrome.
Example 4:
the woman menstrual blood simulating liquid is prepared from the following raw materials in parts by weight:
868.45g of tertiary water, 40g of sodium chloride, 1g of sodium citrate, 3g of sodium hydroxide, 5g of potassium carbonate, 1g of glycerol, 1g of sodium carboxymethylcellulose, 75g of milk powder, 0.025g of fatty acid shanglitan, 0.025g of lauric acid, 0.5g of lactic acid and 2g of haematochrome.
The preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. taking the sodium chloride, the sodium citrate, the sodium hydroxide, the potassium carbonate, the glycerol, the sodium carboxymethyl cellulose, the fatty acid shanli, the lauric acid and the lactic acid according to the weight, pouring the mixture into a beaker, and stirring and mixing the mixture uniformly by using a glass rod;
b. taking the three-stage water with the weight, slowly pouring the three-stage water into the beaker, and stirring the three-stage water with a glass rod while pouring the three-stage water; then placing the beaker on a magnetic stirrer, and stirring for 15min at a stirring speed of 600r/min to obtain a solution A;
c. pouring 220mL of the stirring solution A in each time, placing the stirring solution A on a small-sized stirrer, stirring for 5min at the stirring speed of 11000r/min, and mixing the liquid stirred in each time to obtain a stirring solution B;
d. pouring 220mL of the stirring solution B in each time, placing the stirring solution B on a small-sized stirrer, stirring for 4min at the stirring speed of 11000r/min, and mixing the liquid stirred in each time to obtain a stirring solution C;
e. pouring 220mL of the stirring solution C in each time, placing the stirring solution C on a small-sized stirrer, stirring for 8min at the stirring speed of 11000r/min, and mixing the liquid stirred in each time to obtain a stirring solution D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the protein powder in parts by weight into the filtrate obtained in the step f, stirring until the protein powder is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min at a stirring speed of 800r/min to obtain a stirring solution E;
h. and adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for 39 hours to obtain the haematochrome.
Example 5:
the woman menstrual blood simulating liquid is prepared from the following raw materials in parts by weight:
870.4g of tertiary water, 40g of sodium sulfate, 5g of citric acid, 5g of phosphoric acid, 2g of gelatin, 75g of milk powder, 0.05g of sodium dodecyl sulfate, 0.05g of glycerin monostearate, 0.5g of lactic acid and 2g of haematochrome.
The preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. pouring the sodium sulfate, the citric acid, the phosphoric acid, the glycerol, the sodium dodecyl sulfate, the glyceryl monostearate and the lactic acid into a beaker, and stirring and mixing uniformly by using a glass rod;
b. taking the three-stage water with the weight, slowly pouring the three-stage water into the beaker, and stirring the three-stage water with a glass rod while pouring the three-stage water; then placing the beaker on a magnetic stirrer, and stirring for 15min at a stirring speed of 600r/min to obtain a solution A;
c. pouring 280mL of the stirring solution A in each time, placing the stirring solution A on a small-sized stirrer, stirring for 4min at the stirring speed of 15000r/min, and mixing the liquid stirred in each time to obtain a stirring solution B;
d. pouring 280mL of the stirring solution B in each time, placing the stirring solution B on a small-sized stirrer, stirring for 8min at the stirring speed of 15000r/min, and mixing the liquid stirred in each time to obtain a stirring solution C;
e. pouring 280mL of the stirring solution C in each time, placing the stirring solution C on a small-sized stirrer, stirring for 5min at the stirring speed of 15000r/min, and mixing the liquid stirred in each time to obtain a stirring solution D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the soybean milk powder in parts by weight into the filtrate obtained in the step f, stirring until the soybean milk powder is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min at a stirring speed of 600r/min to obtain a stirring solution E;
h. and adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for 40 hours to obtain the haematochrome.
Example 6
The simulation solution for menstrual blood of women and the preparation method thereof were as in example 1, except that sodium dodecylbenzenesulfonate was substituted for sodium dodecylsulfate and glyceryl monostearate in an equal weight ratio.
Example 7
The menses simulant for women and the method for preparing the same are as in example 2, except that glycerin is replaced by polyvinyl alcohol and gum arabic in equal weight ratio.
The small-sized stirrer can be a soybean milk machine.
And (3) experimental determination:
firstly, experimental raw materials:
1. standard solution: a standard synthetic test solution in appendix G published for the national standard (GB/T22875-; 2. human blood; 3. the menses simulant for women of the various embodiments of the present invention.
Second, Experimental methods
The standard solution, the human blood and the female menstrual blood simulating solution of the embodiments of the invention are respectively tested for pH value, viscosity, density and surface tension indexes, wherein:
the pH value is measured by a method in national standard GB 9724-2007 general rules for measuring pH value of chemical reagents;
the viscosity is measured by the method in the national standard GB/T5561-2012 method for measuring the viscosity and the flow property by using a rotary viscometer for surfactants;
the density measurement adopts the method in the national standard GB/T22230-;
the surface tension index is measured by a method in national standard GB/T22237-2008 'determination of surface tension of surfactant'.
Third, experimental results
The test results are shown in table 1. By comparison, the prepared menses simulant has the pH value of 7.20 +/-0.5, the viscosity of 7.0 +/-0.8 mPa.s and the density of 1.06 +/-0.05 g/cm at room temperature2The surface tension is between 40 +/-4 mN/m, the surface tension is closer to the menstrual blood of women compared with the standard solution, and the test result has more guiding significance for actual production compared with the existing standard solution when the test result is used for measuring the permeation and absorption properties of sanitary towel products and high-absorptivity resin materials.
TABLE 1 comparison of the Parametric Performance of the inventive examples with human blood and standard solutions
Claims (10)
1. The woman menstrual blood simulation fluid is characterized by being prepared from the following raw materials in parts by weight:
950 portions of tertiary water 820-containing materials, 40-50 portions of inorganic sodium salt, 9-12 portions of acid-base regulator, 1-3 portions of thickening agent, 75-90 portions of simulation modifier, 0.05-0.3 portion of simulation regulator, 0.5-1.5 portions of preservative and 2-3 portions of red pigment.
2. The menstrual blood simulant of claim 1, wherein: the menstrual blood simulant has pH value of 7.20 + -0.5, viscosity of 7.0 + -0.8 mPa.s, and density of 1.06 + -0.05 g/cm2And the surface tension is between 40 +/-4 mN/m.
3. The menstrual blood simulant of claim 1, wherein: the water-based color-changing agent is prepared from 859.35 parts of tertiary water, 45 parts of inorganic sodium salt, 10 parts of an acid-base regulator, 2 parts of a thickening agent, 80 parts of a simulation modifier, 0.15 part of a simulation regulator, 1 part of a preservative and 2.5 parts of a red pigment.
4. The menstrual blood simulant of claim 1, wherein: the milk powder is prepared from 868.45 parts of tertiary water, 40 parts of sodium chloride, 1 part of sodium citrate, 3 parts of sodium hydroxide, 5 parts of potassium carbonate, 1 part of glycerol, 1 part of sodium carboxymethylcellulose, 75 parts of milk powder, 0.025 part of fatty acid shanglitan, 0.025 part of lauric acid, 0.5 part of lactic acid and 2 parts of haematochrome.
5. The menstrual blood simulant of claim 1, wherein: the acid-base regulator is two or more of citric acid, phosphoric acid, sodium hydroxide, potassium carbonate, sodium citrate and potassium dihydrogen phosphate.
6. The menstrual blood simulant of claim 1, wherein: the thickener is one or more of glycerol, sodium carboxymethylcellulose, gelatin, polyvinyl alcohol and gum arabic.
7. The menstrual blood simulant of claim 1, wherein: the simulation modifier is protein powder, soybean milk powder or milk powder.
8. The menstrual blood simulant of claim 1, wherein: the simulation regulator is one or more of fatty acid shanli tan, lauric acid, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate and glycerin monostearate.
9. The menstrual blood simulant of claim 1, wherein: the preservative is lactic acid or sodium benzoate, and the inorganic sodium salt is sodium sulfate or sodium chloride.
10. The menstrual blood simulant of claim 1, wherein: the preparation method of the woman menstrual blood simulant comprises the following operation steps:
a. pouring the inorganic sodium salt, the acid-base regulator, the thickening agent, the simulation regulator and the preservative in parts by weight into a beaker, and stirring and mixing uniformly;
b. slowly pouring the three-stage water in parts by weight into the beaker, and stirring with a glass rod while pouring; then placing the beaker on a magnetic stirrer, and stirring for 15min to obtain a solution A;
c. pouring 300mL of 200-300mL of stirring liquid A each time, placing the stirring liquid A on a stirrer, stirring for 4-8min, and mixing the liquid obtained after each stirring to obtain stirring liquid B;
d. pouring 300mL of 200-300mL of stirring liquid B in each time, placing the stirring liquid B on a stirrer, stirring for 4-8min, and mixing the liquid stirred in each time to obtain stirring liquid C;
e. pouring 200-300mL of the stirring liquid C in each time, placing the stirring liquid C on a stirrer, stirring for 4-8min, and mixing the liquid obtained after each stirring to obtain stirring liquid D;
f. filtering the stirring solution D with 300-mesh filter cloth to obtain filtrate;
g. adding the simulation modifier in parts by weight into the filtrate obtained in the step f, stirring until the simulation modifier is completely dissolved, putting the mixture on a magnetic stirrer, and fully stirring for 15min to obtain a stirring solution E;
h. adding the haematochrome in parts by weight into the stirring liquid E, uniformly stirring, and standing for not less than 36 hours to obtain the haematochrome-containing mixed solution;
the stirring speed of the magnetic stirrer is 600-900 r/min; the stirring speed of the stirrer is 9000-.
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