CN114011481A - Piezoelectric type capillary liquid drop preparation device and using method thereof - Google Patents
Piezoelectric type capillary liquid drop preparation device and using method thereof Download PDFInfo
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- CN114011481A CN114011481A CN202111451120.XA CN202111451120A CN114011481A CN 114011481 A CN114011481 A CN 114011481A CN 202111451120 A CN202111451120 A CN 202111451120A CN 114011481 A CN114011481 A CN 114011481A
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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Abstract
The invention provides a piezoelectric capillary liquid drop preparation device and a using method thereof. The invention has simple structure, the piezoelectric ceramic plate is pasted on the liquid storage container, after excitation voltage is applied, the capillary needle tube at the end part of the liquid storage container can generate vibration, liquid drops at the needle point can generate rotary motion due to the vibration, when the liquid drops reach a certain size, the liquid drops can be thrown out by centrifugal force, and the liquid drops can generate different rotating speeds and generate liquid drops with different sizes by controlling the size of the applied excitation signal.
Description
Technical Field
The invention relates to the technical field of droplet preparation, in particular to a piezoelectric type capillary droplet preparation device and a using method thereof.
Background
The droplet preparation technology is a rapidly developed field, and is widely applied to the fields of biochemistry, medicine, materials and the like, such as digital droplet PCR, drug screening, single cell RNA sequencing, cell 3D culture technology and nano material chemistry. The preparation technology of the liquid drop goes through the traditional methods such as emulsification and the like, the micro-fluidic technology and the new off-chip method in recent years. The traditional liquid drop preparation methods such as an emulsification method and layer-by-layer assembly are still widely used up to now due to simple process and high efficiency, but the requirements on uniform, accurate and controllable liquid drop size are more and more difficult to meet with the development of the fields such as biochemistry and medicine.
The microfluidic technology has the advantages of small size, high response speed and accurate control of the size of the liquid drop, but has the defects of high chip manufacturing cost and inconvenience for high-flux liquid drop preparation, so in recent years, many scholars propose various off-chip liquid drop preparation and control technologies.
The centrifugal force preparation technology of liquid drops is characterized in that a micro centrifugal machine platform is used, a liquid drop container is rotated, the centrifugal force is utilized to push an aqueous solution to pass through a micro nozzle array, and then micro drops are extruded and fly into an oil phase to be collected. Centrifugal processes can produce and collect monodisperse droplets for further use. However, since the apparatus cannot be continuously loaded with the aqueous phase, the amount of droplets produced is small, limiting its range of application. The shear force droplet making technique is to use shear force to cut the fluid. The capillary is vertically inserted into oil (continuous phase), the water solution (dispersed phase) is pumped into the capillary by rotating the capillary and simultaneously using a syringe pump, the water solution droplets near the orifice of the capillary move with the oil, so that shearing force is generated constantly, and the droplets are generated when the shearing force overcomes the resistance of the droplets such as surface force and the like along with the increase of the volume of the droplets. However, to avoid high polydispersity of the droplet size, the throughput of droplet generation is relatively low (<2 mol/min).
In summary, the microfluidic technology requires preparation of microchannel chips, which is very costly, and other off-chip technologies require use of motors and other devices, which results in a complex structure, and the simple structure of the needle-based system droplet preparation technology cannot prepare droplets of different sizes, and requires replacement of injection needles of different inner diameters. Therefore, a new droplet preparation technology is needed.
Disclosure of Invention
The invention aims to provide a piezoelectric capillary liquid drop preparation device and a using method thereof.A rectangular piezoelectric ceramic plate applies excitation voltage to generate bending vibration of a capillary tube, liquid drops at the needle tip part of the capillary tube generate rotary motion due to vibration, the liquid drops can be thrown out by centrifugal force when reaching a certain size, and the liquid drops can generate liquid drops with different rotating speeds and sizes by controlling the size of the applied excitation signal.
According to one object of the invention, the invention provides a piezoelectric type capillary liquid drop preparation device which comprises a capillary needle tube, a liquid storage container and a piezoelectric ceramic piece, wherein the capillary needle tube is arranged at the front end of the liquid storage container, and the piezoelectric ceramic piece is fixed on the side wall of the liquid storage container.
Furthermore, the number of the piezoelectric ceramic pieces is two, and the two piezoelectric ceramic pieces are respectively arranged on two opposite side walls of the liquid storage container.
Furthermore, the polarization direction of the piezoelectric ceramic pieces is the thickness direction, and the two piezoelectric ceramic pieces are glued on the liquid storage container and keep the polarization directions consistent.
Further, the piezoelectric ceramic plate and the capillary needle tube are bonded on the liquid storage container by AB glue.
Furthermore, the piezoelectric ceramic plate is connected with an excitation signal generating device, and the excitation voltage of the excitation signal generating device is adjustable.
Further, the upper end and the lower end of the liquid storage container are fixed through a clamp, the clamp comprises two pressing plates, the two pressing plates are located at the upper end and the lower end of the liquid storage container respectively, a supporting pad made of soft materials is arranged between the pressing plates and the liquid storage container, and the two pressing plates are connected through bolts.
Further, the resonance frequency of the liquid storage container is 1.4 kHz.
Further, the capillary needle tube is a stainless steel capillary needle tube, the liquid storage container is a metal liquid storage container, and the supporting pad is made of resin materials.
According to another aspect of the present invention, there is provided a method of using a piezoelectric capillary droplet preparation apparatus, comprising the steps of:
s1, applying an excitation signal to the piezoelectric ceramic plate, enabling the liquid storage container and the capillary needle tube to vibrate, and enabling the needle tip of the capillary needle tube to swing greatly in amplitude;
s2, enabling liquid drops at the needle point of the capillary needle tube to generate rotary motion and gradually increase, and gradually increasing the centrifugal force;
s3, when the mass of the liquid drop reaches the maximum value, the centrifugal force overcomes the suction force of the liquid drop and the needle tip and separates.
Furthermore, by controlling the magnitude of the excitation voltage of the excitation signal, the amplitude of the needle tip of the capillary tube can be changed, so that the liquid drops rotate at different rotating speeds to generate liquid drops with different sizes.
The technical scheme of the invention has simple structure, the piezoelectric ceramic plate is adhered to the liquid storage container, after excitation voltage is applied, the capillary needle tube at the end part of the liquid storage container can generate vibration, liquid drops at the needle point can generate rotary motion due to the vibration, when the liquid drops reach a certain size, the liquid drops can be thrown out by centrifugal force, and the liquid drops can generate different rotating speeds and generate liquid drops with different sizes by controlling the size of the applied excitation signal.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a schematic structural diagram of an embodiment of the present invention;
FIG. 2 is a front view of an embodiment of the present invention;
FIG. 3 is a side view of an embodiment of the present invention;
FIG. 4 is a schematic diagram illustrating the size variation of a droplet according to an embodiment of the present invention;
description of reference numerals: 1-stainless steel capillary, 2-metal liquid storage container, 3-piezoelectric ceramic piece, 31-first piezoelectric ceramic piece, 32-second piezoelectric ceramic piece, 4-clamp, 5-fastening bolt, 6-pressing plate and 7-supporting pad.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise. Furthermore, the terms "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1
As shown in fig. 1, 2 and 3:
the utility model provides a piezoelectric type capillary liquid drop preparation facilities, includes stainless steel capillary 1, metal stock solution container 2 and piezoceramics piece 3, and the front end of metal stock solution container 2 is equipped with stainless steel capillary needle tubing 1, and stainless steel capillary 1 aligns with 2 center pins of metal stock solution container, adopts AB glue adhesive mode to connect.
The two opposite side walls of the metal liquid storage container 2 are respectively fixed with a piezoelectric ceramic piece 3, the piezoelectric ceramic pieces 3 comprise a first piezoelectric ceramic piece 31 and a second piezoelectric ceramic piece 32, and the first piezoelectric ceramic piece 31 and the second piezoelectric ceramic piece 32 are respectively bonded on two sides of the metal liquid storage container 2. The polarization direction of the piezoelectric ceramic sheet 3 is the thickness direction, and the polarization directions of the first piezoelectric ceramic sheet 31 and the second piezoelectric ceramic sheet 32 are the same. The first piezoelectric ceramic piece 31 and the second piezoelectric ceramic piece 32 are bonded to the maximum vibration deformation position of the metal liquid storage container 2 by using AB glue.
Wiring and electrifying modes of the piezoelectric ceramic piece 3: the surfaces of the first piezoelectric ceramic piece 31 and the second piezoelectric ceramic piece 32, which are bonded to the metal liquid storage container 2, are connected to the same electrode, and the surfaces of the first piezoelectric ceramic piece 31 and the second piezoelectric ceramic piece 32, which are far away from the surface of the metal liquid storage container 2, are connected to the other electrode. After the sine excitation signal is applied, in the first half period of the sine signal, the first piezoelectric ceramic piece 31 expands, and the second piezoelectric ceramic piece 32 contracts; in the second half cycle of the sine signal, the first piezoelectric ceramic piece 31 contracts, and the second piezoelectric ceramic piece 32 contracts and expands, so that the metal liquid storage container 2 generates bending vibration under excitation, and the metal capillary needle tube 1 generates vibration under excitation of the metal liquid storage container 2.
In the embodiment, the metal liquid storage container can be vibrated by adopting the piezoelectric ceramic piece, and can also be vibrated by adopting other vibration excitation devices, so that the capillary needle tube can generate large-amplitude bending vibration.
The upper end and the lower end of the metal liquid storage container 2 are fixed through a clamp 4, and the clamp 4 is connected to a node of the metal liquid storage container 2; the fastening bolt 5 clamps the metal reservoir 2 to the clamp 4. Anchor clamps 4 include two clamp plates 6, and two clamp plates 6 are located the upper and lower both ends of metal stock solution container 2 respectively, are equipped with the supporting pad 7 that soft resin material made between clamp plate 6 and the metal stock solution container 2, connect through fastening bolt 5 between two clamp plates 6. The clamp 4 can be made of other materials with soft texture, the structure is not limited, and the clamp can be connected with a node of the metal liquid storage container 2 in the working process to fix the container.
The liquid supply mode of the capillary tube can directly store liquid in a liquid supply groove of the metal liquid storage container 2, and the liquid flows into the capillary tube by utilizing the gravity of the liquid. This method has the advantage of eliminating the pump, a device. Meanwhile, a silicone tube can be connected to the other end of the metal liquid storage container 2 and connected with a liquid injection pump, and a liquid pumping mode is adopted. The advantage of this method is that different droplet preparation rates can be achieved by controlling the flow rate.
The use method of the piezoelectric capillary liquid drop preparation device comprises the following steps:
s1, applying an excitation signal to the piezoelectric ceramic plate, enabling the liquid storage container and the capillary needle tube to vibrate, and enabling the needle tip of the capillary needle tube to swing greatly in amplitude;
s2, enabling liquid drops at the needle point of the capillary needle tube to generate rotary motion and gradually increase, and gradually increasing the centrifugal force;
s3, when the mass of the liquid drop reaches the maximum value, the centrifugal force overcomes the suction force of the liquid drop and the needle tip and separates.
The piezoelectric capillary liquid drop preparation device can change the amplitude of the needle point of the capillary tube by controlling the excitation voltage of the excitation signal, so that liquid drops rotate at different rotating speeds to generate liquid drops with different sizes.
As shown in fig. 4, when the resonant frequency of the metal reservoir of this embodiment is 1.4kHz, and the frequency of the applied excitation signal is 1.4kHz, the droplets with voltages of 160V, 140V, and 120V are generated as the figure, and at this time, the droplet rotation speeds are: 76RPM, 99RPM, 158 RPM; the size of the generated liquid drops is in the range of 0.6mm-2.4 mm.
The technical scheme of the invention has simple structure, the rectangular piezoelectric ceramic plate is pasted on the metal rectangular container, after excitation voltage is applied, the metal capillary at the end part of the metal liquid storage container can generate bending vibration, liquid drops of a needle point can generate rotary motion due to the vibration, when the liquid drops reach a certain size, the liquid drops can be thrown out by centrifugal force, and by controlling the size of the applied excitation signal, the liquid drops can generate different rotating speeds and generate liquid drops with different sizes.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. The piezoelectric type capillary liquid drop preparation device is characterized by comprising a capillary needle tube, a liquid storage container and a piezoelectric ceramic piece, wherein the capillary needle tube is arranged at the front end of the liquid storage container, and the piezoelectric ceramic piece is fixed on the side wall of the liquid storage container.
2. The piezoelectric capillary droplet preparation apparatus according to claim 1, wherein the number of the piezoelectric ceramic plates is two, and the two piezoelectric ceramic plates are respectively disposed on two opposite side walls of the liquid storage container.
3. The piezoelectric capillary droplet preparation apparatus according to claim 2, wherein the polarization direction of the piezoelectric ceramic sheet is a thickness direction, and the polarization directions of the two piezoelectric ceramic sheets are kept consistent when the two piezoelectric ceramic sheets are glued to the liquid storage container.
4. The piezo-electric capillary droplet maker according to claim 1 wherein the piezo-ceramic plate and the capillary tube are bonded to the reservoir using AB glue.
5. The piezo-electric capillary droplet preparation device according to claim 1 wherein the piezo-ceramic plate is connected to an excitation signal generator, the excitation voltage of which is adjustable.
6. The piezoelectric capillary droplet preparation device according to claim 1, wherein the upper and lower ends of the liquid storage container are fixed by a clamp, the clamp comprises two pressing plates, the two pressing plates are respectively located at the upper and lower ends of the liquid storage container, a support pad made of a soft material is arranged between the pressing plates and the liquid storage container, and the two pressing plates are connected by a bolt.
7. The piezoelectric capillary droplet preparation device according to claim 1 wherein the resonance frequency of the reservoir is 1.4 kHz.
8. The piezoelectric capillary droplet preparation apparatus according to claim 6, wherein the capillary tube is a stainless steel capillary tube, the liquid storage container is a metal liquid storage container, and the support pad is made of a resin material.
9. Use of a piezo capillary droplet preparation device according to any of claims 1 to 8, comprising the steps of:
s1, applying an excitation signal to the piezoelectric ceramic piece, wherein the liquid storage container and the capillary needle tube vibrate, and the needle tip of the capillary needle tube swings greatly in amplitude;
s2, enabling liquid drops at the needle point of the capillary needle tube to generate rotary motion and gradually increase, and gradually increasing centrifugal force;
s3, when the mass of the liquid drop reaches the maximum value, the centrifugal force overcomes the suction force of the liquid drop and the needle tip and separates.
10. The method of using a piezo capillary droplet generator according to claim 9 wherein the amplitude of the tip of the capillary tube is varied by controlling the magnitude of the excitation voltage of the excitation signal to rotate the droplet at different rotational speeds to generate droplets of different sizes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115007236A (en) * | 2022-06-06 | 2022-09-06 | 湖北大学 | Portable liquid drop manufacturing device based on centrifugal oscillation and liquid drop manufacturing method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100120130A1 (en) * | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
| WO2013189973A1 (en) * | 2012-06-20 | 2013-12-27 | Consejo Superior De Investigaciones Científicas (Csic) | Fuel cell and analysis device that comprise it |
| CN103733059A (en) * | 2011-07-06 | 2014-04-16 | 先进流体逻辑公司 | Reagent storage on a droplet actuator |
| CN104038100A (en) * | 2014-06-25 | 2014-09-10 | 哈尔滨工业大学 | Multi-foot rotational piezoelectric actuator and excitation method for implementing cross-scale actuation therefor |
| US20170253914A1 (en) * | 2014-11-17 | 2017-09-07 | Institute Of Microbiology, Chinese Academy Of Sciences | Apparatus, system, and method for dispensing or mixing micro quantity of liquid |
| CN108927234A (en) * | 2018-05-15 | 2018-12-04 | 西安交通大学 | It is a kind of to be impulsed the drop generating system of mechanism based on piezoelectricity |
| CN211101606U (en) * | 2019-10-17 | 2020-07-28 | 上海睿度光电科技有限公司 | Micro-distribution device for liquid metal under normal temperature condition |
| US20210053063A1 (en) * | 2019-08-20 | 2021-02-25 | 10X Genomics, Inc. | Devices and methods for generating and recovering droplets |
-
2021
- 2021-12-01 CN CN202111451120.XA patent/CN114011481B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100120130A1 (en) * | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
| CN103733059A (en) * | 2011-07-06 | 2014-04-16 | 先进流体逻辑公司 | Reagent storage on a droplet actuator |
| WO2013189973A1 (en) * | 2012-06-20 | 2013-12-27 | Consejo Superior De Investigaciones Científicas (Csic) | Fuel cell and analysis device that comprise it |
| CN104038100A (en) * | 2014-06-25 | 2014-09-10 | 哈尔滨工业大学 | Multi-foot rotational piezoelectric actuator and excitation method for implementing cross-scale actuation therefor |
| US20170253914A1 (en) * | 2014-11-17 | 2017-09-07 | Institute Of Microbiology, Chinese Academy Of Sciences | Apparatus, system, and method for dispensing or mixing micro quantity of liquid |
| CN108927234A (en) * | 2018-05-15 | 2018-12-04 | 西安交通大学 | It is a kind of to be impulsed the drop generating system of mechanism based on piezoelectricity |
| US20210053063A1 (en) * | 2019-08-20 | 2021-02-25 | 10X Genomics, Inc. | Devices and methods for generating and recovering droplets |
| CN211101606U (en) * | 2019-10-17 | 2020-07-28 | 上海睿度光电科技有限公司 | Micro-distribution device for liquid metal under normal temperature condition |
Non-Patent Citations (2)
| Title |
|---|
| 安大伟等: "《超声毛细管液滴制备器》", 《第 18 届全国非线性振动暨第 15 届全国非线性动力学和运动稳定性学术会议（NVND2021）摘要集》 * |
| 陈乾伟等: "《单相斜轨塔形直线超声电机设计与实验X》", 《振动工程学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115007236A (en) * | 2022-06-06 | 2022-09-06 | 湖北大学 | Portable liquid drop manufacturing device based on centrifugal oscillation and liquid drop manufacturing method thereof |
| CN115007236B (en) * | 2022-06-06 | 2024-03-29 | 湖北大学 | Portable liquid drop manufacturing device based on centrifugal oscillation and liquid drop manufacturing method thereof |
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