CN114010768A - Gynecological external medicine formula - Google Patents

Gynecological external medicine formula Download PDF

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Publication number
CN114010768A
CN114010768A CN202111303241.XA CN202111303241A CN114010768A CN 114010768 A CN114010768 A CN 114010768A CN 202111303241 A CN202111303241 A CN 202111303241A CN 114010768 A CN114010768 A CN 114010768A
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CN
China
Prior art keywords
parts
matrine
fibronectin
indigo naturalis
gynecological
Prior art date
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Withdrawn
Application number
CN202111303241.XA
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Chinese (zh)
Inventor
张晋
张立大
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Individual
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Individual
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Priority to CN202111303241.XA priority Critical patent/CN114010768A/en
Publication of CN114010768A publication Critical patent/CN114010768A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/02Suppositories; Bougies; Bases therefor; Ovules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a gynecological external medicine formula which comprises the following raw materials in parts by mass: 3 parts of matrine, 2 parts of indigo naturalis powder, 1 part of fibronectin and a mixed medium. The preparation method comprises the following steps: step one, selecting 3 parts of matrine, 2 parts of indigo naturalis powder and 1 part of fibronectin, and uniformly mixing; step two, putting the mixture obtained in the step one into a machine for stirring, and adding carbomer gel or mixed fatty glyceride for full fusion during stirring; and step three, canning the fusion obtained in the step two. Compared with the prior art, the invention has the advantages that: the product has broad-spectrum insecticidal, antibacterial, HPV virus killing, anti-inflammatory, hemostatic, and rapid healing and repairing functions of damaged mucosa, and has remarkable curative effect on various vaginitis, cervical erosion and cervical cancer, good applicability, and convenient popularization.

Description

Gynecological external medicine formula
Technical Field
The invention relates to the field of gynecological diseases, in particular to a gynecological external medicine formula.
Background
Mycotic vaginitis, trichomonas vaginitis and non-gonococcal vaginitis are common frequently-occurring diseases and are also various in treatment medicines. The external medicine is a lotion for treating gynecological inflammation, is simple to use and has a certain curative effect. In addition, Western medicines such as nystatin and metronidazole have good bactericidal and anti-inflammatory effects on trichomonas and anaerobic bacillus. In the aspect of traditional Chinese medicine, there are also many medicines for treating gynecological inflammation.
Disclosure of Invention
The invention aims to solve the technical problems that the existing gynecological external medicine has poor use effect and high preparation cost, and does not meet clinical requirements.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: the gynecological external medicine formula comprises the following raw materials in parts by mass:
1 part of matrine, 1 part of indigo naturalis powder, 0.5 part of fibronectin and a mixed medium.
Compared with the prior art, the invention has the advantages that: the product has the functions of killing and inhibiting bacteria, killing HPV virus, diminishing inflammation, stopping bleeding and healing and repairing damaged mucous membrane, and has obvious curative effect on vaginitis, cervical erosion and cervical cancer, high adaptability, easy popularization, high safety and reliability and no toxic side effect and untoward reaction.
Further, the feed comprises the following raw materials in parts by mass:
2 parts of matrine, 1.5 parts of indigo naturalis powder, 0.7 part of fibronectin and a mixed medium.
Further, the feed comprises the following raw materials in parts by mass:
3 parts of matrine, 2 parts of indigo naturalis powder, 1 part of fibronectin and a mixed medium.
Further, the mixing medium is carbomer gel or mixed fatty glyceride.
Further, the preparation method comprises the following steps:
step one, selecting 3 parts of matrine, 2 parts of indigo naturalis powder and 1 part of fibronectin, and uniformly mixing;
step two, putting the mixture obtained in the step one into a machine for stirring, and adding carbomer gel or mixed fatty glyceride for full fusion during stirring;
and step three, canning the fusion obtained in the step two.
Detailed Description
The invention is implemented in detail, and the gynecological external medicine formula comprises the following raw materials in parts by mass:
1 part of matrine, 1 part of indigo naturalis powder, 0.5 part of fibronectin and a mixed medium.
The composite material comprises the following raw materials in parts by mass:
2 parts of matrine, 1.5 parts of indigo naturalis powder, 0.7 part of fibronectin and a mixed medium.
The composite material comprises the following raw materials in parts by mass:
3 parts of matrine, 2 parts of indigo naturalis powder, 1 part of fibronectin and a mixed medium.
The mixing medium is carbomer gel or mixed fatty glyceride.
The preparation method comprises the following steps:
step one, selecting 3 parts of matrine, 2 parts of indigo naturalis powder and 1 part of fibronectin, and uniformly mixing;
step two, putting the mixture obtained in the step one into a machine for stirring, and adding carbomer gel or mixed fatty glyceride for full fusion during stirring;
and step three, canning the fusion obtained in the step two.
The working principle of the invention is as follows: the formula is an external gynecological medicament formula, and raw materials comprise 3 parts of matrine, 2 parts of indigo naturalis powder, 1 part of fibronectin and a mixed medium, wherein the mixed medium is carbomer gel or mixed fatty glyceride.
The preparation method comprises the following steps: mixing the above three materials, stirring mechanically, mixing with carbomer gel, and packaging.
The using method comprises the following steps: injecting 3-5g of gel into vagina every day.
Example (b):
in this embodiment, the manufacturing method is improved, and the raw materials include 3 parts of matrine, 2 parts of natural indigo powder, 1 part of fibronectin and a mixed medium, wherein the mixed medium is carbomer gel or mixed fatty glyceride. Mixing the above three materials, stirring mechanically, mixing with carbomer gel, making into suppository, and packaging.
The using method comprises the following steps: 2-3g of the suppository is taken every day and is inserted into the vagina.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made in the above embodiments by those of ordinary skill in the art without departing from the principle and spirit of the present invention.

Claims (5)

1. The gynecological external medicine formula is characterized by comprising the following raw materials in parts by mass:
1 part of matrine, 1 part of indigo naturalis powder, 0.5 part of fibronectin and a mixed medium.
2. The formula for the external gynecological medicine according to claim 1, which is characterized by comprising the following raw materials in parts by mass:
2 parts of matrine, 1.5 parts of indigo naturalis powder, 0.7 part of fibronectin and a mixed medium.
3. The formula for the external gynecological medicine according to claim 1, which is characterized by comprising the following raw materials in parts by mass:
3 parts of matrine, 2 parts of indigo naturalis powder, 1 part of fibronectin and a mixed medium.
4. The gynecological external use drug formulation according to claim 1, characterized in that: the mixing medium is carbomer gel or mixed fatty glyceride.
5. The gynecological external use medicine formula according to claim 1, characterized in that the preparation method is as follows:
step one, selecting 3 parts of matrine, 2 parts of indigo naturalis powder and 1 part of fibronectin, and uniformly mixing;
step two, putting the mixture obtained in the step one into a machine for stirring, and adding carbomer gel or mixed fatty glyceride for full fusion during stirring;
and step three, canning the fusion obtained in the step two.
CN202111303241.XA 2021-11-05 2021-11-05 Gynecological external medicine formula Withdrawn CN114010768A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111303241.XA CN114010768A (en) 2021-11-05 2021-11-05 Gynecological external medicine formula

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111303241.XA CN114010768A (en) 2021-11-05 2021-11-05 Gynecological external medicine formula

Publications (1)

Publication Number Publication Date
CN114010768A true CN114010768A (en) 2022-02-08

Family

ID=80061200

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111303241.XA Withdrawn CN114010768A (en) 2021-11-05 2021-11-05 Gynecological external medicine formula

Country Status (1)

Country Link
CN (1) CN114010768A (en)

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Application publication date: 20220208