CN113993592A - 针对携带酪氨酸激酶抑制剂耐药性egfr突变的癌症的化合物 - Google Patents

针对携带酪氨酸激酶抑制剂耐药性egfr突变的癌症的化合物 Download PDF

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CN113993592A
CN113993592A CN202080044361.XA CN202080044361A CN113993592A CN 113993592 A CN113993592 A CN 113993592A CN 202080044361 A CN202080044361 A CN 202080044361A CN 113993592 A CN113993592 A CN 113993592A
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cancer
mutations
egfr
bosutinib
exon
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J·罗比丘
M·尼尔森
J·V·海马赫
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The University of Texas System
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CN202080044361.XA 2019-04-17 2020-04-16 针对携带酪氨酸激酶抑制剂耐药性egfr突变的癌症的化合物 Pending CN113993592A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962835343P 2019-04-17 2019-04-17
US62/835,343 2019-04-17
PCT/US2020/028540 WO2020214824A1 (en) 2019-04-17 2020-04-16 Compounds against cancer bearing tyrosine kinase inhibitor resistant egfr mutations

Publications (1)

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CN113993592A true CN113993592A (zh) 2022-01-28

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CN202080044361.XA Pending CN113993592A (zh) 2019-04-17 2020-04-16 针对携带酪氨酸激酶抑制剂耐药性egfr突变的癌症的化合物

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US (1) US20220175779A1 (enExample)
EP (1) EP3956035A4 (enExample)
JP (1) JP7709384B2 (enExample)
KR (1) KR20220004089A (enExample)
CN (1) CN113993592A (enExample)
AU (1) AU2020257395A1 (enExample)
BR (1) BR112021020601A2 (enExample)
CA (1) CA3132819A1 (enExample)
IL (1) IL287115A (enExample)
MX (1) MX2021012705A (enExample)
PH (1) PH12021552579A1 (enExample)
SG (1) SG11202111120VA (enExample)
WO (1) WO2020214824A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024153256A1 (zh) * 2023-01-16 2024-07-25 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途

Families Citing this family (8)

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MX2021010265A (es) 2019-02-26 2021-09-23 Janssen Biotech Inc Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos.
US12629375B2 (en) 2019-03-29 2026-05-19 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 21 insertions
MY208668A (en) 2019-05-14 2025-05-23 Janssen Biotech Inc Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
BR112022015140A2 (pt) 2020-02-12 2022-10-11 Janssen Biotech Inc Tratamento de pacientes que têm mutações de salto do éxon 14 de c-met
EP4284950A4 (en) * 2021-01-29 2024-12-25 Board of Regents, The University of Texas System METHODS OF TREATMENT OF CANCER USING KINASE INHIBITORS
US20240108623A1 (en) * 2021-01-29 2024-04-04 Board Of Regents, The University Of Texas System Methods of treating cancer with poziotinib
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3

Citations (3)

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WO2017198602A1 (en) * 2016-05-18 2017-11-23 Boehringer Ingelheim International Gmbh Anticancer combination therapy
WO2018094225A1 (en) * 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
US20180333415A1 (en) * 2017-05-19 2018-11-22 Regents Of The University Of Minnesota Therapeutic methods

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EP3120851A1 (en) * 2015-07-21 2017-01-25 Pangaea Biotech S.L. 4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8h)-one for treatment of solid cancers
JP7386174B2 (ja) * 2018-03-27 2023-11-24 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｈｅｒ２エクソン１９変異を有するがん細胞に対する抗腫瘍活性を有する化合物
SG11202012064PA (en) * 2018-06-25 2021-01-28 Spectrum Pharmaceuticals Inc Combination of poziotinib with cytotoxic agent and/or other molecularly targeted agent and use thereof
KR20210066819A (ko) * 2018-09-04 2021-06-07 레인 세러퓨틱스 인코포레이티드 Her-유도 암을 치료 또는 예방하기 위한 화합물, 조성물 및 방법
MX2021010265A (es) * 2019-02-26 2021-09-23 Janssen Biotech Inc Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos.
US20220143023A1 (en) * 2019-03-29 2022-05-12 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 insertions
US12629375B2 (en) * 2019-03-29 2026-05-19 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 21 insertions

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2017198602A1 (en) * 2016-05-18 2017-11-23 Boehringer Ingelheim International Gmbh Anticancer combination therapy
WO2018094225A1 (en) * 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
US20180333415A1 (en) * 2017-05-19 2018-11-22 Regents Of The University Of Minnesota Therapeutic methods

Non-Patent Citations (1)

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Title
JACQULYNE P. ROBICHAUX等: "Mechanisms and Clinical Activity of an EGFR and HER2 Exon 20-selective Kinase Inhibitor in Non-small Cell Lung Cancer", NAT MED., vol. 24, no. 5, pages 638 - 646, XP036901056, DOI: 10.1038/s41591-018-0007-9 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024153256A1 (zh) * 2023-01-16 2024-07-25 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途
GB2641652A (en) * 2023-01-16 2025-12-10 Weishang Shanghai Bio Pharmaceutical Co Ltd Use of quinazoline compound in overcoming Osimertinib drug resistance

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MX2021012705A (es) 2021-11-12
JP2022529945A (ja) 2022-06-27
BR112021020601A2 (pt) 2021-12-07
AU2020257395A1 (en) 2021-11-04
WO2020214824A1 (en) 2020-10-22
PH12021552579A1 (en) 2022-08-01
CA3132819A1 (en) 2020-10-22
IL287115A (en) 2021-12-01
SG11202111120VA (en) 2021-11-29
EP3956035A1 (en) 2022-02-23
KR20220004089A (ko) 2022-01-11
JP7709384B2 (ja) 2025-07-16
EP3956035A4 (en) 2023-01-25
US20220175779A1 (en) 2022-06-09

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