CN113952622A - Infrared device and application thereof - Google Patents
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
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- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
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- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
Abstract
The present invention provides an infrared device for skin treatment, comprising: an infrared assembly, comprising: the infrared emission film, electrodes respectively electrically connected with the infrared emission film, and external leads respectively connected with the electrodes, wherein the wavelength of infrared rays emitted by the infrared emission film is 1-25 μm; and the external controller is electrically connected with the external lead and is used for controlling the infrared emission film to emit infrared rays and enabling the heating temperature of the infrared emission film to reach 30-60 ℃. The invention further provides an application of the infrared device in skin treatment.
Description
Technical Field
The invention relates to an infrared device and application thereof in treating skin warts.
Background
The dermatosis is related to skin diseases, is one of common diseases and frequently encountered diseases which seriously affect the health of people, and has the characteristics of high morbidity, high disability rate, strong infectivity, long treatment time and the like. With the increasing environmental pollution, the incidence of skin diseases is increasing. It is reported that the skin disease is a disease with the highest incidence, the highest disability rate and the strongest infectivity in human in the 21 st century historically. The data shows that the national dermatological drug market scale in 2018 reaches 167.31 billion yuan, which is a 4.3% increase on a par with the same. According to the research report on Chinese market assessment of skin disease drugs and investment direction (2018), it is shown that about 4.2 hundred million people suffer from skin diseases worldwide, wherein about 1.5 million patients exist in China.
More and more people suffering from skin diseases are concerned about symptomatic treatment. For example, cutaneous warts are a common cutaneous Human Papilloma Virus (HPV) infection, with an average prevalence of 3-13% in the population, and higher in children. Daily activities and quality of life can be significantly affected by local discomfort, restricted movement, etc. The common clinical treatment methods include freezing, electrocautery, laser surgery, external salicylic acid and the like, but the effect and the side effect are different. Generally, the cure rate is not more than 50%. Cases of intractable warts are challenging because of cosmetic problems, treatment resistance and frequent recurrence for the patient himself, the dermatologist and the physician.
Disclosure of Invention
The invention provides an infrared device and application thereof in treating skin warts, which can effectively solve the problems.
The invention is realized by the following steps:
the present invention provides an infrared device for treatment of skin warts, comprising:
an infrared assembly, comprising: the infrared emission film, electrodes respectively electrically connected with the infrared emission film, and external leads respectively connected with the electrodes, wherein the wavelength of infrared rays emitted by the infrared emission film is 1-25 μm;
and the external controller is electrically connected with the external lead and is used for controlling the infrared emission film to emit infrared rays and enabling the heating temperature of the infrared emission film to reach 30-60 ℃.
The invention further provides an infrared device for skin wart treatment, comprising:
an infrared assembly, comprising: the infrared emission film, electrodes respectively electrically connected with the infrared emission film, and external leads respectively connected with the electrodes, wherein the wavelength of infrared rays emitted by the infrared emission film is that of infrared rays emitted by a human body;
and the external controller is electrically connected with the external lead and is used for controlling the infrared emission film to emit infrared rays and enabling the heating temperature of the infrared emission film to reach 30-60 ℃.
The invention further provides an application of the infrared device in treating skin warts.
The invention has the beneficial effects that: the device of the invention can achieve complete removal (22/34) in 64.7% of cases of skin warts, and the sum of cure and significant cases accounts for 82%; the nail warts of 12 participants (12/13) achieved higher complete removal and achieved zero scarring. In addition, no other side effects were observed with the device of the present invention, except that the child participants complained of a mild and well tolerated burning sensation. In addition, the infrared treatment device has high energy utilization rate and high infrared radiation ratio; the equipment is portable and portable; is soft and bendable, and is suitable for different affected parts and different sizes of affected parts; can be applied to affected part for treatment, so that infrared radiation can act on affected part as much as possible to avoid attenuation (infrared radiation can be gradually attenuated in air). Finally, the invention can conveniently and accurately control the treatment temperature and time and record the use time period of the patient through the control of the APP, and can upload the picture of the affected part at the same time, thereby facilitating the tracking of the whole treatment process by the doctor.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a schematic structural diagram of an infrared assembly for treating skin warts, provided by an embodiment of the invention.
Fig. 2 is a side view of an infrared assembly for treating skin warts, as provided by an embodiment of the present invention.
Fig. 3 is a far infrared spectrum of the emission of an infrared assembly for treating skin warts as provided by an embodiment of the present invention.
Fig. 4 is a schematic structural diagram of an external controller in an infrared device for treating skin warts, provided by the embodiment of the invention.
In fig. 5, c is a photograph of the powered patch covered by the infrared component for treating skin warts provided by the embodiment of the invention on a finger wart, and d is a corresponding infrared image through a temperature recorder.
FIG. 6 is a photographic comparison of treatment progress and results within 3 months for representative patients with refractory warts.
FIG. 7 is a photograph comparing the progress and results of treatment in 3 months for representative patients with refractory warts.
FIG. 8 is a photograph comparing the progress and results of treatment in 3 months for a representative patient with drusen.
Figure 9 is a comparison of the lesion pathology and immunofluorescence of the participants of figure 8 before (left) and two weeks after (right) treatment.
Fig. 10 is a wearable device for treating skin warts provided by an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Referring to fig. 1, an embodiment of the present invention provides an infrared assembly 100 for treating skin warts, comprising:
an infrared emission film 11, wherein the wavelength of infrared rays emitted by the infrared emission film 11 is 1 μm to 200 μm;
and external leads 13 respectively connected to the electrodes 12.
The infrared component 100 is covered on the position of skin diseases caused by human body skin wart infection, and can emit infrared light with the temperature of 30-60 ℃ and the wavelength of 1-200 mu m after the power supply is switched on, thereby effectively removing the human body skin wart and improving the local immunity.
The electrode 12 and the external lead 13 may be an integrated structure or an independent structure, which is not limited herein.
The heating temperature of the infrared emission film 11 may be further 35 to 45 ℃. Preferably, the infrared emission film 11 emits infrared rays with wavelengths simulating middle and far infrared rays of a human body, namely, middle infrared rays with a wavelength of 1 μm to 25 μm, and the heating temperature of the infrared emission film 11 is 39 ℃ to 43 ℃. More preferably, the infrared emission film 11 emits infrared rays having a wavelength similar to human far infrared, i.e., a medium-far infrared light (more than 80%) having a wavelength of 5 μm to 15 μm, and the infrared emission film 11 is heated at a temperature of 40 ℃ to 42 ℃. The infrared emission film 11 is a flexible film, and the material of the infrared emission film 11 is not limited, and any material that is non-toxic and can emit infrared light may be used. In one embodiment, the infrared emission film 11 is made of carbon-based conductive ink.
Specifically, 100-1000 times of expanded graphite is crushed to D50 being 200 mu m; then, forming a conductive agent by the expanded graphite and the conductive carbon black according to the mass ratio of 6-10: 1; 5-20 wt% of a conductive agent, 20-30 wt% of acrylic resin, rheological additive castor oil (the amount is wt 3-6% of the conductive agent), silane coupling agent (the amount is 0.5-2 wt% of the conductive agent), and the balance of a mixed solvent composed of terpineol and ethanol according to the mass ratio of 3:7, so as to obtain a mixture; stirring the mixture for more than 10 minutes by using a high-speed stirrer to obtain uniform carbon-based conductive ink precursor dispersion liquid without bubbles; ball-milling the carbon-based conductive ink precursor dispersion liquid until the fineness is lower than 20 mu m, and obtaining the carbon-based conductive ink according to the viscosity of 1000-13000 mPa & s in different printing modes; then, the carbon-based conductive ink is subjected to gravure printing, screen printing, coating and the like on a bearing substrate 10 to obtain a wet film, and then the wet film is dried and cured at a low temperature (200 ℃) to obtain the infrared emission film 11.
In one example, the expanded graphite was crushed 450 times to D50 ═ 200 μm; then, forming a conductive agent by the expanded graphite and the conductive carbon black according to the mass ratio of 8: 1; 10 wt% of conductive agent, 25 wt% of acrylic resin, rheological additive castor oil (the amount is 5 wt% of the conductive agent), silane coupling agent (the amount is 1 wt% of the conductive agent), and the balance of mixed solvent composed of terpineol and ethanol according to the mass ratio of 3:7 to obtain a mixture; stirring the mixture for more than 10 minutes by using a high-speed stirrer to obtain uniform carbon-based conductive ink precursor dispersion liquid without bubbles; ball-milling the carbon-based conductive ink precursor dispersion liquid until the fineness is lower than 20 mu m, and obtaining the carbon-based conductive ink according to the viscosity of 1000-13000 mPa & s in different printing modes; and then coating the carbon-based conductive ink on a bearing substrate 10 to obtain a wet film, and drying and curing at a low temperature (200 ℃) to obtain the infrared emission film 11. Referring to fig. 3, fig. 3 shows a far infrared spectrum emitted from the infrared emission film 11 provided in this embodiment, wherein the wavelength of the far infrared spectrum is mainly in a range of 5-15 micrometers (more than 80%) which is very close to the range of normal human body radiation (i.e., the far infrared spectrum emits infrared rays imitating human bodies). The expanded graphite forms graphene, carbon atoms vibrate and collide with each other under the condition of electrification to generate heat energy, the heat energy is mainly radiated in a far infrared ray mode with the wavelength of 5-15 mu m, and the effective electric heat conversion efficiency reaches more than 99%. The infrared with the wavelength of 5-15 μm is considered as 'life light wave', is matched with the vibration frequency wave band of human cell molecules, and is easy to absorb by human bodies.
In other embodiments, the infrared assembly 100 may further include a carrier substrate 10, and the infrared emission film 11 is at least partially disposed on a surface of the carrier substrate 10. The bearing substrate 10 is a flexible film such as PI, PET, a silica gel film, polyester fabric, nylon fabric, non-woven fabric, polyurethane fabric and leather; or hard sheet structures such as glass sheets, mica sheets or ceramic sheets. The carrier substrate 10 may be cut to fit various parts of the human body, such as fingers, toes, joints, etc., and will not be described in detail herein.
Further, in other embodiments, the infrared assembly 100 may further include an infrared reflection film 17 disposed on a surface of the carrier substrate 10 away from the infrared emission film 11, for reflecting the infrared rays emitted from the infrared emission film 11 in the same direction.
Further, in other embodiments, the infrared module 100 may further include a temperature sensor 15 disposed between the infrared emission film 11 and the carrier substrate 10 for acquiring a heating temperature of the infrared emission film 11. It can be understood that the temperature of the infrared emission film 11 can be obtained in real time through the temperature sensor 15, the temperature can be accurately controlled, and the skin can be prevented from being scalded due to overheating.
Further, in other embodiments, the infrared assembly 100 may further include a gauze 14 covering the surface of the infrared emission film 11 away from the carrier substrate 10, so as to prevent the graphite from directly contacting the skin during treatment.
Further, in other embodiments, the infrared assembly 100 may further include a fixing member 16 disposed on the carrier substrate 10 for fixing the infrared emission film 11 to different parts of human skin. The fixing member 16 is a hook and loop fastener or a buckle.
Further, in other embodiments, the infrared module 100 may further include an external connector 18 or an external interface connected to the external lead 13 for connecting with an external controller 200. In other embodiments, the external connector 18 or external interface is embedded in the carrier substrate 10 and partially exposed, thereby preventing damage.
Referring to fig. 4, an embodiment of the present invention provides an infrared device for treating skin warts, comprising:
the infrared component 100; and
the external controller 200, the external controller 200 includes a connection jack 20. The external connector 18 is inserted into the connection jack 20 to connect the external controller 200 to the infrared module 100.
Further, the external controller 200 includes a switch 21 and a control button 22. The control button 22 can adjust temperature and time. The optimum temperature and time may be set in the off-board controller 200. Generally speaking, the optimal temperature is 40-42 ℃, and the optimal treatment time is 30-60 minutes each time. However, for different individuals, the temperature can be reduced by controlling the button 22 when the temperature is too high, and the temperature can be increased by controlling the button 22 when the temperature is too low.
In other embodiments, the external controller 200 may further have a memory module (not shown). The memory module is used for storing basic information of the patient and treatment parameter information. The basic information includes name, disease location, etc. The treatment parameter information comprises an optimal treatment temperature, an optimal treatment time, the total time length of treatment and the like. When the patient name is entered, the relevant parameter information can be retrieved for treatment without additional adjustment. The external controller 200 may further include a camera module (not shown) for taking pictures of different time periods according to the treatment time period of the patient and storing the pictures in the memory module. Specifically, the external controller 200 may control the camera module to obtain the photos of the affected part according to the interval time (e.g., every week or month), and present the photos before and after the treatment to the doctor for comparison, thereby facilitating the adjustment of the treatment scheme in time.
The infrared device is applied to treatment of skin warts:
it is documented in the Chinese clinical trial registration center (ChiCRT2000037609) that the experiment is designed to treat refractory warts with the infrared device provided by the present invention and observe its clinical efficacy and safety. In the study, refractory warts are selected, 36 in all cases and 2 in all cases are exfoliated. The final 34 cases were included in the analysis. 20 of the women and 14 of the women. The mean age was 23.9 ± 11.4, the maximum age was 46 years, and the minimum age was 7 years. The subjects were treated externally for 40 minutes at 42 ℃ per day (FIG. 5). The course of treatment was recorded and photographed. Side reactions in the experiment were also observed and recorded. Efficacy results were evaluated at 12 weeks of treatment and defined as Complete clearance (CC, reduction of 100% in wart size and number, restoration of normal skin at close examination), near Complete clearance (NCC, 75% -99%), partial clearance (PCC, 50% -74%) and no response (reduction less than 50%). Treatment success was defined as CC and NCC. Digital photographs of the warts were taken at baseline and outcome assessment, respectively, as shown below.
The overall remission rate was found to be 82.4%, with 95% CI of 65.2-93.2, with a lower limit of 65.2% higher than 58% of the current standard of treatment (power ═ 0.76). The differences of remission rates of different parts, different age groups and different sexes are compared by using Fisher's exact probability method, and the differences are found to have no statistical significance (figure 6). FIG. 6 is a photograph of treatment progress and results within 3 months of a representative patient with refractory warts. From left to right, the lesions are completely cleared before, 1 month, 2 months and 3 months after treatment.
TABLE 1 therapeutic efficacy after 12 weeks of treatment
Note: overall remission rate (OR) ═ number of curative cases + number of significant cases)/total cases treated
TABLE 2 analysis of the therapeutic effects of different parts
TABLE 3 analysis of the therapeutic effects of different age groups
TABLE 4 analysis of the therapeutic effects of different parts
For the most challenging nail warts, 12 of 13 participants were completely cleared. Especially, children patients are easy to bite and hurt the nail part, the pain of the treatment by the traditional means is hard to endure, the wart body invades and grows inwards along with the treatment, and the device of the scheme has the most difficult of the virus wart, achieves good effect, and is comfortable and easy to accept (figures 7-8). FIG. 7 is a photograph of treatment progress and results within 3 months of a representative patient with refractory warts. From left to right, the lesions are completely cleared before, 1 month, 2 months and 3 months after treatment. FIG. 8 shows the hallux-hinolaryngeal warts, which, after long-term treatment, cause the downward invasive growth of the wart and the disfigurement and hyperplasia of the nail plate. The device can be used for treating wart removal, and the toenails grow normally.
Fig. 9 shows that the participants in fig. 8 showed a significant increase in red fluorescence signal recruitment at the site of the lesion compared to the left, before (left) and after (right) two weeks of treatment, indicating that activated langerhans cells at the site of the lesion aggregated and enhanced local immunity.
In conclusion, the device of the invention can recruit, activate Langerhans cells to enter the skin lesion, improve the extraction and delivery capacity of Langerhans cells to viral antigens, improve the local immunity, clear viruses and cure skin infection.
Comparative example:
the comparative example uses a metal wire electrothermal film as a heating chip to carry out a contrast experiment. Total 20 cases, 5 cases with abscission, and 15 final cases were analyzed. The number of the male patients is 11, and the number of the female patients is 4. The age is 20-30 years. The treatment was carried out at 42 ℃ for 40 minutes per day. The results showed that the overall remission rate was only 46.7% with 95% CI ranging from 21.3 to 73.5. During the treatment, 6 people feedback slight burning feeling, and no other side effect is observed. In contrast, the overall therapeutic effect of the far infrared device prepared by the method is obviously superior to that of a metal wire electrothermal film device.
TABLE 5 curative effect of electrothermal film of metal wire after 12 weeks of treatment
Note: overall remission rate (OR) ═ number of curative cases + number of significant cases)/total cases treated
Referring to fig. 10, fig. 10 is a wearable device 300 for treating skin warts, according to an embodiment of the present invention, where the wearable device 300 is a sock. It is to be understood that the wearable device 300 is not limited to socks, but may be gloves, scarves, hats, coats, knee pads, wristbands, and the like, without limitation thereto.
Specifically, the wearable device 300 includes a body 30, an infrared module 100 disposed inside the body 30, and a control module 31. It is understood that the infrared assembly 100 is not limited to be disposed at the position corresponding to the toes, but may be disposed at the sole or other positions, which is not limited herein. The control module 31 is electrically connected to the infrared module 100, and is configured to control the infrared module 100 to emit infrared rays, and to enable the heating temperature of the infrared module to reach 30-60 ℃. The control module 31 may set a plurality of fixed treatment modes. For example, the control module 31 may set the heating temperature to 42 ℃ and the heating time to 40 minutes; when the switch is opened, it automatically executes the treatment mode. In other embodiments, the control module 31 may further include a communication module (not shown), and a user may communicate with the communication module through a smart terminal to execute different control commands. For example, the communication module is a bluetooth module, and after a user downloads APP through a smart phone and connects with the smart phone via bluetooth, the user controls the infrared module 100 to execute a corresponding instruction by inputting heating temperature and heating time.
Embodiments of the present invention further provide a wearable system for treating skin warts, comprising:
a body 30;
the infrared component 100 is arranged in the body 30, and the wavelength of infrared rays emitted by the infrared component 100 is 1-200 μm; and
the control module 31 is arranged on the body 30 and is used for controlling the infrared component 100 to emit infrared rays and enabling the heating temperature of the infrared component to reach 30-60 ℃, and the control module 31 further comprises a communication module;
install APP's intelligent terminal, it passes through communication module with control module group 31 communication makes control module group 31 carries out different control command.
Of course, the APP may store basic information of the patient as well as treatment parameter information. The basic information includes name, disease location, etc. The treatment parameter information comprises an optimal treatment temperature, an optimal treatment time, the total time length of treatment and the like. The APP can be further used for uploading pictures of affected parts of patients in different treatment periods. This photo can upload to the high in the clouds, and the doctor can compare the photo around will treating through the high in the clouds to be favorable to the doctor in time to adjust the treatment scheme, and feed back to corresponding patient.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An infrared device, for skin treatment, comprising:
an infrared assembly (100), comprising: the infrared module comprises an infrared emission film (11), electrodes (12) respectively and electrically connected with the infrared emission film (11), and external leads (13) respectively connected with the electrodes (12), wherein the wavelength of infrared rays emitted by the infrared emission film (11) is 1-25 μm, the infrared module (100) further comprises a bearing substrate (10), and at least part of the infrared emission film (11) is arranged on the surface of the bearing substrate (10);
and the external controller (200) is electrically connected with the external lead (13) and is used for controlling the infrared emission film (11) to emit infrared rays and enabling the heating temperature to reach 30-60 ℃.
2. The infrared device according to claim 1, characterized in that said external controller (200) further has a memory module; the memory module is used for storing basic information of the patient and treatment parameter information; the basic information comprises names and disease positions; the treatment parameter information comprises an optimal treatment temperature, an optimal treatment time and the total length of treatment time.
3. The infrared device according to claim 2, wherein said optimum treatment time is 30 to 60 minutes/time.
4. The infrared device according to claim 1, characterized in that the infrared emission film (11) emits more than 80% of infrared rays having a wavelength of 5 μm to 15 μm.
5. The infrared device according to claim 1, characterized in that said infrared emission film (11) is made by means of a carbon-based conductive ink.
6. The infrared device of claim 5, wherein the carbon-based conductive ink is prepared by a method comprising:
crushing 100-1000 times of expanded graphite to D50 ═ 200 mu m; then, forming a conductive agent by the expanded graphite and the conductive carbon black according to the mass ratio of 6-10: 1; 5-20 wt% of a conductive agent, 20-30 wt% of acrylic resin, rheological additive castor oil and silane coupling agent, wherein the dosage of the rheological additive castor oil is wt 3-6% of the dosage of the conductive agent, and the dosage of the silane coupling agent is wt 3-6% of the dosage of the conductive agent; and the balance of a mixed solvent consisting of terpineol and ethanol in a mass ratio of 3:7 to obtain a mixture; stirring by using a high-speed stirrer to obtain uniform carbon-based conductive ink precursor dispersion without bubbles; ball-milling the carbon-based conductive ink precursor dispersion liquid until the fineness is lower than 20 mu m, and obtaining the carbon-based conductive ink according to the viscosity of 1000-13000 mPa & s in different printing modes.
7. The infrared device according to claim 6, characterized in that said infrared emission film (11) is obtained by obtaining a wet film by gravure printing, screen printing or coating said carbon-based conductive ink on said carrier substrate (10), followed by drying and curing at low temperature.
8. An infrared device for use in skin wart treatment, comprising:
an infrared assembly (100), comprising: the infrared emission film (11), electrodes (12) which are respectively and electrically connected with the infrared emission film (11), and external leads (13) which are respectively connected with the electrodes (12), wherein the wavelength of infrared rays emitted by the infrared emission film (11) is that of infrared rays emitted by a human body;
and the external controller (200) is electrically connected with the external lead (13) and is used for controlling the infrared emission film (11) to emit infrared rays and enabling the heating temperature to reach 30-60 ℃.
9. Use of an infrared device as defined in claim 1 or 8 for the treatment of skin.
10. Use of an infrared device according to claim 1 or 8 for the treatment of skin warts.
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