CN113940900A - Lip protecting ointment for softening lip cutin and improving lip state and preparation method thereof - Google Patents

Lip protecting ointment for softening lip cutin and improving lip state and preparation method thereof Download PDF

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Publication number
CN113940900A
CN113940900A CN202111125641.6A CN202111125641A CN113940900A CN 113940900 A CN113940900 A CN 113940900A CN 202111125641 A CN202111125641 A CN 202111125641A CN 113940900 A CN113940900 A CN 113940900A
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lip
alcohol
lip balm
urea
cutin
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蒙宇
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Guangzhou Nabion Biotechnology Co ltd
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Guangzhou Nabion Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/001Preparations for care of the lips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention belongs to the technical field of cosmetics, and discloses lip protecting ointment for softening lip cutin and improving lip state and a preparation method thereof. The lip care ointment comprises the following components: urea, shea butter, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol. The lip protecting ointment of the invention performs the synergistic interaction effect by the compounding of urea, shea butter, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol, thereby achieving the effects of accelerating the softening of the cutin of the lips and improving the state of the lips. The lip protecting ointment avoids potential damage and discomfort caused by the traditional lip cutin treatment mode of removing cutin by adding ground particles such as sucrose particles and nut shell powder.

Description

Lip protecting ointment for softening lip cutin and improving lip state and preparation method thereof
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to lip protecting ointment for softening lip cutin and improving lip state and a preparation method thereof.
Background
In the field of lip care, products such as lip gloss, lip sleeping masks, lip cream, lip scrub, lip sunscreen, and the like, in addition to the most basic lip gloss, come to the consumers, and the development of lip care products has been increasingly diversified. The lip scrub is one of products having a function of removing the horny layer of lips, sucrose particles with different particle sizes, nut shell powder such as walnut powder and the like are often used as an abrasive, but obvious friction feeling exists in the exfoliating process, sensitive lips feel obvious pain feeling, the use feeling of the product is poor, and the potential possibility of scratching the skin is high.
The prior related art discloses a lip scrub and a preparation method thereof, which comprises 50-60 wt% of sucrose, 30-60 wt% of petrolatum, 3-8 wt% of tridecyl alcohol trimellitate, 4-6 wt% of hydrogenated castor oil, 0.3-0.6 wt% of preservative and 0.2-0.3 wt% of aromatic. The prepared lip scrub cream has good smearing property, and can effectively remove aged cutin and dead skin. But the sucrose content is extremely high, obvious friction feeling can be felt in the using process, and the potential of scratching the skin is realized.
The prior related art discloses a lip scrub cream and a preparation method thereof, and the lip scrub cream comprises 1-20 parts of macadamia nut shell powder, 1-30 parts of cane sugar, 1-10 parts of honey, 1-10 parts of royal jelly, 1-5 parts of allantoin, 1-5 parts of hydrogenated castor oil, 1-25 parts of natural vegetable oil, 1-25 parts of natural wax and 1-5 parts of a preservative. According to the invention, macadamia shell and sucrose are used as an abrasive, the macadamia shell has high hardness and an adsorption function to remove lip cutin, and honey, royal jelly, natural vegetable oil and natural wax reduce damage caused by friction. Although the invention is designed to reduce the damage caused by friction through honey, royal jelly, natural vegetable oil and natural wax, the crystal irregularity of the friction agent still gives the potential possibility of scratching the skin and the uncomfortable feeling during use.
In conclusion, for the treatment of the cutin of the lip skin, the cutin of most products is directly removed in a physical friction mode, the rubbing discomfort exists in the process, the cutin needs to be removed by clean water after use, the injury to the lip skin is caused by secondary friction such as paper towel cleaning and the like, and the potential possibility of scratching deep skin is caused by physical friction. Therefore, there is a need to develop a lip care product that can prevent skin from being scratched, soften cutin, and make the aged cutin of lips naturally fall off, thereby achieving the purpose of improving the state of lips.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the invention provides lip protecting ointment for softening lip cutin and improving lip state and a preparation method thereof.
The first aspect of the present invention provides a lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the following components: urea, shea butter, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol.
It is to be noted that, the components of the present invention: glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol are available from the Ashland group under the product model prolipid 141.
The lip protecting mechanism of the lip protecting ointment is as follows:
urea increases the water content of the stratum corneum of the skin, softens the stratum corneum, swells it, and changes the permeability and activity coefficients of the osmotically active ingredient, thereby promoting penetration of the active ingredient.
The main component of prolipid 141 is a plant-derived oil-water amphiphilic molecular structure, and the dosage is carefully balanced to form a stable layered gel phase system of bionic lipid. Ordered layered structures are crucial for building strong barrier protection and optimal hydration. The lipid membrane can be provided on the upper layer of the horny layer to form a water-locking layer which greatly reduces the water loss, thereby accelerating the skin repairing process; the ability of prolipid 141 to rapidly and effectively increase skin hydration is reflected by changes in skin conductance.
The shea butter is rich in saturated fatty acid and unsaturated fatty acid, and the unsaturated fatty acid has a certain transdermal penetration promoting effect. The fatty acid compound has a structure similar to that of fatty acid in skin, unsaturated double bonds exist in the molecule to enable the fatty acid compound to have an asymmetric spatial structure, when the fatty acid molecule is inserted into a lipid bimolecular hydrophobic structure of stratum corneum lipid, due to the cis-structure of the unsaturated hydrophobic chains, the bimolecular layer is twisted to form a fine flow channel easy to permeate, the ordered arrangement of the stratum corneum lipid structure is effectively influenced, and therefore the percutaneous absorption of active ingredients is promoted. The shea butter is easy to be melted on the skin when being smeared on the skin, and a thin oil film is formed on the surface to moisten and soften the skin.
The lip care ointment disclosed by the invention has a synergistic effect by compounding the urea, the shea butter and prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol), and can soften the cutin of lips and improve the state of the lips. The lip protecting ointment avoids potential damage and discomfort caused by the traditional lip cutin treatment mode of removing cutin by adding ground particles such as sucrose particles and nut shell powder.
Preferably, the weight percentage of the urea to the lip care ointment is 0.01-1%, the weight percentage of the shea butter to the lip care ointment is 1-5%, and the total weight percentage of the glyceryl stearate, the behenyl alcohol, the palmitic acid, the stearic acid, the myristyl alcohol, the lecithin, the lauryl alcohol and the cetyl alcohol to the lip care ointment is 0.5-8%.
Preferably, the weight percentage of the urea to the lip care ointment is 0.15-0.5%, the weight percentage of the shea butter to the lip care ointment is 1-3%, and the total weight percentage of the glyceryl stearate, the behenyl alcohol, the palmitic acid, the stearic acid, the myristyl alcohol, the lecithin, the lauryl alcohol and the cetyl alcohol to the lip care ointment is 2-5%.
Preferably, the composition also comprises the following components: solvent, grease, thickening agent, bacteriostatic agent and antioxidant.
Preferably, the solvent comprises at least one of water, ethanol and plant extract.
The plant extract is prepared by extracting a plant with water or ethanol as a solvent, such as rose water or aloe barbadensis leaf water, and the plant extract contains water or ethanol and can be used for dissolving urea.
Preferably, the oil or fat comprises at least one of mineral oil, petrolatum, di-diglycerol polyacyladipate-2, polybutene, hydrogenated polyisobutene, diisostearyl malate, isononyl isononanoate, caprylic/capric triglyceride, polyglyceryl-3 triisostearate, sunflower seed oil, jojoba seed oil, meadowfoam seed oil, argania spinosa oil.
Preferably, the thickener includes at least one of dimethylsilylated silica, microcrystalline wax, paraffin wax, ceresin, polyethylene, tribehenate, synthetic esters of glycerin fatty acid esters, fatty alcohols, and fatty acids.
Preferably, the antioxidant comprises at least one of tocopherol, tocopherol acetate, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) ester, and butylated hydroxytoluene.
Preferably, the bacteriostatic agent comprises at least one of phenoxyethanol, caprylyl glycol, ethylhexyl glycerin and glyceryl caprylate.
The second aspect of the present invention provides a method for preparing the lip care ointment for softening the cutin of lips and improving the state of the lips, which comprises the following steps:
mixing the components to prepare the lip care ointment.
Preferably, the preparation method of the lip care ointment for softening the cutin of the lips and improving the state of the lips specifically comprises the following steps:
s1, adding the urea into a solvent, stirring until the urea is completely dissolved to obtain a urea solution, heating to 48 +/-2 ℃, and keeping the temperature for later use;
s2, mixing the shea butter, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol, cetyl alcohol and partial grease, heating to 60 +/-2 ℃, stirring until the mixture is completely dissolved, keeping the temperature, adding the urea solution for later use in the step S1 while stirring, stirring and mixing to obtain a mixture, and keeping the temperature for later use; further, prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol, and cetyl alcohol) and shea butter were mixed at a mass ratio of: mixing part of grease 1 (1-3);
s3, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S2, and stirring for 15-30 minutes to obtain the lip care ointment.
Compared with the prior art, the invention has the following beneficial effects:
the lip care ointment disclosed by the invention exerts a synergistic effect by compounding urea, shea butter and prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol), contains a lamellar gel phase, can form a lipid envelope on the surface of lip skin, resists external stimulation, enhances the hydration of the skin by utilizing an ordered lamellar structure and effective components of the lamellar gel phase, greatly reduces water loss, increases the rate of water in a corium layer moving to a horny layer, and can change the permeability of the horny layer, so that the effects of accelerating softening of the lip horny layer and improving the state of the lips are achieved. The lip protecting ointment avoids potential damage and discomfort caused by the traditional lip cutin treatment mode of removing cutin by adding ground particles such as sucrose particles and nut shell powder.
Drawings
FIG. 1 is a graph showing the improvement in lip condition of one subject in test example 2 of the present invention.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
The starting materials, reagents or apparatuses used in the following examples are conventionally commercially available or can be obtained by conventionally known methods, unless otherwise specified.
The composition Prolipid 141 in the following examples contains glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol, available from the Ashland group.
Example 1
A lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the components shown in Table 1.
TABLE 1
Figure BDA0003276857950000041
Figure BDA0003276857950000051
The preparation method of the lip care ointment comprises the following steps:
s1, adding urea into the solvent, stirring until the urea is completely dissolved to obtain a urea solution, heating to 48 +/-2 ℃, and keeping the temperature for later use;
s2, mixing shea butter, Prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol) and partial grease, heating to 60 +/-2 ℃, stirring to be completely dissolved, keeping the temperature, adding the urea solution for later use in the step S1 while stirring, stirring and mixing to obtain a mixture, and keeping the temperature for later use; wherein, according to the mass ratio, prolipid 141 and shea butter: part of grease is 1: 1;
s3, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S2, and stirring for 15-30 minutes to obtain the lip care ointment.
Example 2
A lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the components shown in Table 2.
TABLE 2
Figure BDA0003276857950000052
Figure BDA0003276857950000061
The lip balm of this example was prepared in the same manner as in example 1.
Example 3
A lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the components shown in Table 3.
TABLE 3
Figure BDA0003276857950000062
Figure BDA0003276857950000071
The lip balm of this example was prepared in the same manner as in example 1.
Example 4
A lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the components shown in Table 4.
TABLE 4
Figure BDA0003276857950000072
Figure BDA0003276857950000081
The lip balm of this example was prepared in the same manner as in example 1.
Example 5
A lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the components shown in Table 5.
TABLE 5
Figure BDA0003276857950000082
The lip balm of this example was prepared in the same manner as in example 1.
Example 6
A lip care ointment for softening the cutin of lips and improving the condition of lips, which comprises the components shown in Table 6.
TABLE 6
Figure BDA0003276857950000091
The lip balm of this example was prepared in the same manner as in example 1.
Comparative example 1
In comparison with example 1, Prolipid 141 was replaced with glycerol stearate in comparative example 1, the composition is shown in table 7.
TABLE 7
Figure BDA0003276857950000092
Figure BDA0003276857950000101
The preparation method of the finished product of the comparative example comprises the following steps:
s1, adding urea into the solvent, stirring until the urea is completely dissolved to obtain a urea solution, heating to 48 +/-2 ℃, and keeping the temperature for later use;
s2, mixing the shea butter, the glycerol stearate and part of grease, heating to 60 +/-2 ℃, stirring until the mixture is completely dissolved, preserving heat, adding the urea solution for later use in the step S1 while stirring, stirring and mixing to obtain a mixture, and preserving heat for later use; wherein, according to the mass ratio, the glycerol stearate and the shea butter: part of grease is 1: 1;
s3, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S2, and stirring for 15-30 minutes to obtain a finished product.
Comparative example 2
In comparison with example 1, comparative example 2 does not contain urea and the composition is shown in table 8.
TABLE 8
Figure BDA0003276857950000102
Figure BDA0003276857950000111
The preparation method of the finished product of the comparative example comprises the following steps:
s1, mixing shea butter, Prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol) and partial grease, heating to 60 +/-2 ℃, stirring to be completely dissolved, keeping the temperature, adding the solvent while stirring, stirring and mixing to obtain a mixture, and keeping the temperature for later use; wherein, according to the mass ratio, prolipid 141 and shea butter: part of grease is 1: 1;
s2, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S1, and stirring for 15-30 minutes to obtain a finished product.
Comparative example 3
In comparison with example 1, in comparative example 3, Prolipid 141 was replaced with glyceryl stearate, while urea and shea butter were not contained, and the compositions are shown in table 9.
TABLE 9
Figure BDA0003276857950000112
Figure BDA0003276857950000121
The preparation method of the finished product of the comparative example comprises the following steps:
s1, mixing glycerol stearate with partial grease according to the mass ratio of 1:1, heating to 60 +/-2 ℃, stirring until the mixture is completely dissolved, preserving heat, adding the solvent while stirring, stirring and mixing to obtain a mixture, and preserving heat for later use;
s2, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S1, and stirring for 15-30 minutes to obtain a finished product.
Comparative example 4
In comparison with example 3, in comparative example 4 in which Prolipid 141 was replaced with glyceryl stearate and shea butter was not contained, the composition is shown in table 10.
Watch 10
Figure BDA0003276857950000122
Figure BDA0003276857950000131
The preparation method of the finished product of the comparative example comprises the following steps:
s1, adding urea into the solvent, stirring until the urea is completely dissolved to obtain a urea solution, heating to 48 +/-2 ℃, and keeping the temperature for later use;
s2, mixing glycerol stearate with partial grease according to the mass ratio of 1:1, heating to 60 +/-2 ℃, stirring until the mixture is completely dissolved, preserving heat, adding the urea solution for later use in the step S1 while stirring, stirring and mixing to obtain a mixture, and preserving heat for later use;
s3, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S2, and stirring for 15-30 minutes to obtain a finished product.
Comparative example 5
In comparison with example 6, comparative example 5 does not contain shea butter and the components are shown in table 11.
TABLE 11
Figure BDA0003276857950000132
Figure BDA0003276857950000141
The preparation method of the finished product of the comparative example comprises the following steps:
s1, adding urea into the solvent, stirring until the urea is completely dissolved to obtain a urea solution, heating to 48 +/-2 ℃, and keeping the temperature for later use;
s2, mixing Prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol) with partial grease according to the mass ratio of 1:1, heating to 60 +/-2 ℃, stirring until the mixture is completely dissolved, preserving heat, adding the urea solution for later use in the step S1 while stirring, stirring and mixing to obtain a mixture, and preserving heat for later use;
s3, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S2, and stirring for 15-30 minutes to obtain a finished product.
Comparative example 6
Compared with example 1, in comparative example 6, Prolipid 141 is replaced by behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol, and other components and preparation methods are the same as those in example 1. The compositions are shown in Table 12.
TABLE 12
Figure BDA0003276857950000142
Figure BDA0003276857950000151
Test example 1 Single open application test (Single open application)
Volunteers 132 with healthy skin and an age between 25 and 55 years were selected as subjects, 12 in each group. The lip balm provided in examples 1 to 6 and comparative examples 1 to 5 was applied to the inner side of the left forearm of the volunteer as a test site, and the placebo cream was applied to the same site as the inner side of the right forearm, and changes in the appearance of the skin of the subject were observed and recorded, and the judgment criteria for skin reaction grade were as shown in the following Table 13:
watch 13
Figure BDA0003276857950000152
The results of the single open-smear test on the samples provided in examples 1-6 and comparative examples 1-6 are shown in table 14 below:
TABLE 14
Figure BDA0003276857950000153
Figure BDA0003276857950000161
As can be seen from the above table 14, the lip care ointment provided by the invention is safe to skin, has no irritation, and can be used safely.
Test example 2 human body test and results
2.1 test principle
Selecting 30 subjects, smearing and trying lips of the subjects according to a double-blind principle, scoring effects after one week of use, and analyzing significant difference of effects of the samples.
2.2 test specimens
Lip balm prepared in example 1
2.3 test objects
30 subjects had dry skin on lips, showed significant water deficit in the stratum corneum, and excluded pregnant or lactating women, people with severe cheilitis, and people with high physical sensitivity.
2.4 test methods
The upper and lower lips are transversely coated once along the lip line. The dosage is about 0.2 ml/time, 2 times per day, and is used in the morning and evening. The test subjects respectively use the product for 1 time in the morning and evening every day, and score the effects of moisturizing, moistening, softening cutin and improving lip state after using the product (the full score is 9 points, and the 5 points are considered to have the effects) so as to show whether the product has the effects of moisturizing, moistening, softening cutin and improving lip state.
2.5 statistical methods
Data analysis was performed using SPSS software.
The significant difference is as follows: at a significance level of alpha-0.05, when p > 0.05, there is no significant difference between the two; when p is less than or equal to 0.05, the two have significant difference. In the SPSS software statistics, sig means "significance", i.e., P-value.
2.6 test results
The results are shown in Table 15:
watch 15
After one week of use Moisturizing effect Moistening effect Softening cutin Improving lip condition
Mean score 7.79 8.13 8.36 7.93
Degree of satisfaction 96.67% 93.33% 90.00% 96.67%
P value (α ═ 0.05) 0.000 0.000 0.000 0.000
Significance difference determination Has significant difference Has significant difference Has significant difference Has significant difference
2.7 analysis of results
As can be seen from table 15, the lip balm prepared in example 1 has the effects of moisturizing, softening keratin, and improving the state of the lips.
In addition, figure 1 shows a graph of the lip state improvement of one of the subjects (who had received their authorization). FIG. 1(a) is the effect of the lips of the subject prior to application, with visible cutin edges of the lips, i.e., slight skinning; figure 1(b) shows the lip effect of the subject at 8 hours after application, showing a significant improvement in keratolytic and chapped condition.
Test example 3 evaluation of sensory Effect of consumers
3.1 test subject
40 volunteers aged between 20-50 years, who were frequently using lip makeup and had lips dry to a dry and cracked condition after makeup removal, were selected as subjects.
3.2 test specimens
Examples 1-6, comparative examples 1-6, a commercially available lip exfoliating scrub, for a total of 13 test samples.
3.3 test methods:
since the subjects were repeatedly participating in the experiment, the development of the corresponding test experiment for each group of test samples was performed at intervals of at least 7 days. The test experiment of example 1 was carried out as day 1, and the test experiment of example 2 was not carried out until day 8.
The test sample is applied to the test sample 1 time after the makeup removing liquid and the makeup removing cotton are used for removing the makeup at night and before the test, if the test sample is not applied to the lips on the same day, the test sample is used after the lips are wiped by the makeup removing liquid and the makeup removing cotton, the test sample is kept on the lips for 8 hours, and the state of the lips after getting up in the morning on the next day is observed and recorded.
3.4 Effect evaluation method
After the end of use, the subjects evaluated the effects of softening keratin before and after the use of the samples, improving the state of lips, and the evaluation results were classified into three grades, i.e., better, general, and no effects.
3.5 evaluation results
The results are shown in Table 16:
TABLE 16
Figure BDA0003276857950000181
3.6 analysis of results
As can be seen from Table 16, examples 1-6 all significantly softened the cutin and improved the dry-crack condition of the lips in a shorter period of time, and examples 1-6 all tested better than comparative examples 1-5 and also better than some commercially available lip exfoliating scrub.
Comparing example 1 with comparative example 1, comparing example 1 with comparative example 2, comparing example 6 with comparative example 5, the three groups of comparison experiments show that the combination of urea, shea butter and Prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol) has obvious synergistic effect, and the effect is better than that of the combination of two.
Comparing example 1 with comparative example 3, it was revealed that the addition of urea, shea butter and Prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol) of the present invention softened cutin and improved the state of lips significantly more than comparative example 3 without the addition of these components.
Comparing example 1 with comparative example 6, and analyzing the results of comparative example 1, it is shown that the compatibility of the components of Prolipid 141 provided by Ashland corporation is unique and synergistic, and that simply mixing known individual components does not achieve the desired efficacy.
Comparing example 3 with comparative example 4, it is shown that the system compounded by urea, shea butter and Prolipid 141 (glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol) of the present invention has better effect of improving the dry state of lips than the system added with urea alone.
In addition, through subject feedback, we also found that examples 1-6 maintained the lips from drying for longer periods of time. Also, in comparative example 2, it was found that there was a remarkable effect of softening keratin, but the effect of moisturizing lips was inferior to those of examples 1 to 6.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that the present invention is not limited to the details of the embodiments shown and described, but is capable of numerous equivalents and substitutions without departing from the spirit of the invention as set forth in the claims appended hereto.

Claims (10)

1. The lip care ointment is characterized by comprising the following components: urea, shea butter, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol.
2. The lip balm according to claim 1, wherein the urea accounts for 0.01-1 wt% of the lip balm, the shea butter accounts for 1-5 wt% of the lip balm, and the glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol account for 0.5-8 wt% of the lip balm.
3. The lip balm according to claim 2, wherein the urea accounts for 0.15-0.5 wt% of the lip balm, the shea butter accounts for 1-3 wt% of the lip balm, and the glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol and cetyl alcohol account for 2-5 wt% of the lip balm.
4. A lip balm according to claim 1, further comprising the following components: solvent, grease, thickening agent, bacteriostatic agent and antioxidant.
5. A lip balm according to claim 4, wherein said solvent comprises at least one of water, ethanol, and a plant extract.
6. A lip balm according to claim 4, wherein said oil comprises at least one of mineral oil, petrolatum, diglycerol polyacyladipate-2, polybutene, hydrogenated polyisobutene, diisostearyl malate, isononyl isononanoate, caprylic/capric triglyceride, polyglyceryl-3 triisostearate, sunflower seed oil, jojoba seed oil, meadowfoam seed oil, and acanga oil.
7. A lip balm according to claim 4, wherein said thickener comprises at least one member selected from the group consisting of dimethylsilylated silica, microcrystalline wax, paraffin wax, ceresin, polyethylene, tribehenate, synthetic esters of glycerin fatty acid esters, fatty alcohols, and fatty acids.
8. A lip balm according to claim 4, wherein said antioxidant comprises at least one of tocopherol, tocopherol acetate, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) ester, butylated hydroxytoluene.
9. A process for producing a lip balm according to any one of claims 1 to 8, which comprises the steps of:
mixing the components to prepare the lip care ointment.
10. The method of claim 9, comprising the steps of:
s1, adding the urea into a solvent, stirring until the urea is completely dissolved to obtain a urea solution, heating to 48 +/-2 ℃, and keeping the temperature for later use;
s2, mixing the shea butter, glyceryl stearate, behenyl alcohol, palmitic acid, stearic acid, myristyl alcohol, lecithin, lauryl alcohol, cetyl alcohol and partial grease, heating to 60 +/-2 ℃, stirring until the mixture is completely dissolved, keeping the temperature, adding the urea solution for later use in the step S1 while stirring, stirring and mixing to obtain a mixture, and keeping the temperature for later use;
s3, mixing the remaining grease, the thickening agent, the bacteriostatic agent and the antioxidant, heating to 88 +/-2 ℃, stirring to completely dissolve, cooling to 70 +/-2 ℃, adding the mixture prepared in the step S2, and stirring for 15-30 minutes to obtain the lip care ointment.
CN202111125641.6A 2021-09-24 2021-09-24 Lip protecting ointment for softening lip cutin and improving lip state and preparation method thereof Pending CN113940900A (en)

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KR100787784B1 (en) * 2006-07-27 2007-12-21 주식회사 코리아나화장품 Cosmetic composition for protecting lip comprising granules
CN107595751A (en) * 2017-08-21 2018-01-19 澳宝化妆品(惠州)有限公司 A kind of lip skin care composition containing agalloch eaglewood anthophorids honey
CN110478281A (en) * 2019-09-26 2019-11-22 广州艾蓓生物科技有限公司 A kind of lip gloss and preparation method thereof of deep moisturizing effect
CN110772448A (en) * 2019-11-20 2020-02-11 广州品赫化妆品有限公司 Lipstick composition with lip plumping effect and preparation method thereof
CN111888276A (en) * 2019-05-06 2020-11-06 太和康美(北京)中医研究院有限公司 Lip care compositions containing novel phytosterol additives and methods of making same
KR20210019315A (en) * 2019-08-12 2021-02-22 주식회사 잉글우드랩코리아 Lip care cosmetic composition for blocking UV comprising chlorella extract as an active ingredient

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100787784B1 (en) * 2006-07-27 2007-12-21 주식회사 코리아나화장품 Cosmetic composition for protecting lip comprising granules
CN107595751A (en) * 2017-08-21 2018-01-19 澳宝化妆品(惠州)有限公司 A kind of lip skin care composition containing agalloch eaglewood anthophorids honey
CN111888276A (en) * 2019-05-06 2020-11-06 太和康美(北京)中医研究院有限公司 Lip care compositions containing novel phytosterol additives and methods of making same
KR20210019315A (en) * 2019-08-12 2021-02-22 주식회사 잉글우드랩코리아 Lip care cosmetic composition for blocking UV comprising chlorella extract as an active ingredient
CN110478281A (en) * 2019-09-26 2019-11-22 广州艾蓓生物科技有限公司 A kind of lip gloss and preparation method thereof of deep moisturizing effect
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