CN113907080A

CN113907080A - Insecticide

Info

Publication number: CN113907080A
Application number: CN202111261330.2A
Authority: CN
Inventors: 魏继燕
Original assignee: Liyang Zhongnan Chemical Industry Co ltd
Current assignee: Liyang Zhongnan Chemical Industry Co ltd
Priority date: 2021-10-28
Filing date: 2021-10-28
Publication date: 2022-01-11

Abstract

The invention relates to the field of pesticides, and particularly relates to an insecticide. The organic acid adjusts the pH of the compounded pesticide to be weakly acidic or neutral, so that the co-toxicity coefficient of the pesticide is increased, and the resistance development of the pesticide is delayed. The application selects the dispersing agent, the wetting agent and the synergist which can play a role in a weak acid or neutral range, can effectively improve the efficacy of the pesticide, can quickly permeate into tissues, improves the up-down conductivity of the pesticide in the tissues and improves the quick-acting property of the pesticide; inhibit or weaken the detoxification of target pests and the like on the activity of pesticides, and delay the metabolic rate of the pesticide in a control object, thereby increasing the biological control effect.

Description

Insecticide

Technical Field

The invention relates to the field of pesticides, and particularly relates to an insecticide.

Background

The problem of resistance to agricultural pests is a global problem and has always been a key issue of concern for agricultural scientists. With the progress of chemical control of pests, the increase of the usage amount of pesticides and the unscientific use of pesticides, the pest resistance is increasingly serious, and the species of pests generating resistance are also increasing. In addition, the pesticide has high intensity, so that pesticide residue of agricultural products exceeds the standard, the environment is polluted, the pesticide cost of farmers is increased, and the like, and the agricultural sustainable development is not facilitated. Therefore, the research and development of high-efficiency, low-toxicity and environment-friendly pesticide have positive significance for agricultural sustainable development.

The compounding of different pesticide varieties is a common method for preventing and controlling agricultural resistant pests, and the compounded pesticide can effectively solve the problem that the resistance of the pesticide in the pests develops quickly. Aiming at the compound pesticide, the inventor finds that the use stability of the effective components of the pesticide is low after the pesticide is compounded, and the improvement and design of the existing compound pesticide are urgently needed to solve the problems.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide an insecticide, the cotoxicity coefficient of the obtained compound pesticide to target organisms is increased, the resistance development of the active ingredients of the pesticide can be effectively slowed down, and the use stability is improved. The inventor of the invention has conducted intensive research on a compound formula using spinetoram and chlorantraniliprole as active components, and found that the spinetoram and the chlorantraniliprole are compounded to prepare a suspending agent, a suspoemulsion, an aqueous emulsion or a microemulsion, and the suspending agent, the suspoemulsion, the aqueous emulsion or the microemulsion have an obvious synergistic interaction effect within a certain proportion range, and the invention is completed through further research.

The application provides a pesticide, which adopts the following technical scheme:

the pesticide comprises active components, an auxiliary agent, organic acid and deionized water, wherein the active components comprise chlorantraniliprole and spinetoram, and the mass ratio of the chlorantraniliprole to the spinetoram to the auxiliary agent to the deionized water is (1) - (1-4): (0.2-0.5): (3-6), adjusting the pH value of the pesticide to 4-7 by using an organic acid.

By adopting the technical scheme, the action modes of chlorantraniliprole and spinetoram on insects are different, and the chlorantraniliprole can be combined with ryanodine receptors of the insects, so that the loss of internal calcium storage is uncontrolled, the normal muscle contraction of the insects is prevented, and the insects can not eat normally and die; spinetoram can directly act on nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors in insect nerves, so that insects are insensitive to excitatory or inhibitory signal transmission reactions, and normal nerve activities are affected until the insects die. The spinetoram and chlorantraniliprole are used as active components, and after the auxiliary agent, the deionized water and the organic acid are added for compounding, the pH value of the pesticide is adjusted, so that the drug properties of the active components are effectively prolonged, and the storage and use stability of the pesticide is improved.

Optionally, the mass ratio of the chlorantraniliprole to the spinetoram is 1 (1.5-3).

By adopting the technical scheme, under the proportion of the raw materials, the co-toxicity coefficient of the compounded pesticide is increased, and the combined toxicity is enhanced, so that the mass ratio of the chlorantraniliprole to the spinetoram is preferably 1 (1.5-3).

Optionally, the organic acid adjusts the pH of the insecticide to 5-7.

By adopting the technical scheme, the normal growth activity of crops is ensured in a weak acid or neutral environment, meanwhile, the drug property of active components in the pesticide can be prolonged, and the stability of the active components is improved.

Optionally, the organic acid is one or more of humic acid, formic acid and acetic acid.

By adopting the technical scheme, the formic acid and the acetic acid in the humic acid and the micromolecule fatty acid are organic acids coexisting in the environment, so that the photodegradation rate of the active components can be effectively inhibited, and the stability of the pesticide is improved. The absorption spectrum of the formic acid and the acetic acid is partially overlapped with the absorption spectrum of the active component, so that the photodegradation of the active component in the pesticide is inhibited, and the stability of the pesticide can be effectively enhanced; the strong acid functional group of humic acid can inhibit the decomposition of active components in the pesticide, thereby effectively enhancing the stability of the pesticide. Humic acid, formic acid and acetic acid improve the pH value of the compounded pesticide, and can effectively inhibit the decomposition of active components in the pesticide, thereby improving the stability of the pesticide.

Optionally, the auxiliary agent comprises a dispersing agent, a wetting agent and a synergist, wherein the mass ratio of the dispersing agent to the wetting agent to the synergist is 1: (0.1-0.3): (0.03-0.15).

By adopting the technical scheme, the dispersing agent, the wetting agent and the synergist can effectively improve the dispersion stability of active components in an insecticide system in insecticide compounding, improve the aggregation resistance stability of the insecticide and reduce the surface energy of deionized water; the components in the pesticide can be dispersed in the deionized water to form a stable system, so that the pesticide can penetrate into plant tissues more quickly, the up-and-down conductivity of the pesticide in the plant tissues is improved, and the quick-acting property and the stability of the pesticide are improved.

Optionally, the auxiliary agent comprises a dispersing agent, a wetting agent and a synergist, wherein the mass ratio of the dispersing agent to the wetting agent to the synergist is 1: (0.1-0.2): (0.04-0.09).

By adopting the technical scheme, in the compounding process of the pesticide, the wetting, spreading, dispersing, detention and permeability of the pesticide can be obviously improved under the matching of the auxiliary agent, the drift of the pesticide along with wind (airflow) is reduced, the damage to adjacent sensitive crops and the like is reduced, and the aims of prolonging the effective period of the pesticide, improving the biological activity of the pesticide, reducing the dosage, reducing the cost and protecting the ecological environment are fulfilled.

Optionally, the dispersant is a polycarboxylate dispersant.

By adopting the technical scheme, the polycarboxylate dispersant has small sensitivity to ions, pH values and temperature in an insecticide system, high dispersion stability and difficult sedimentation and flocculation; the polycarboxylate dispersant improves the content of solid particles, obviously reduces the viscosity of a dispersion system, has better fluidity at high solid content, reduces the cost of raw materials and reduces the abrasion of equipment.

Optionally, the synergist is one or two of ethoxy modified polytrisiloxane and polyhydric alcohol type nonionic surfactant.

By adopting the technical scheme, in weak acid and neutral environments, the ethoxy modified polytrisiloxane is beneficial to wetting the leaf surfaces, so that the pesticide liquid reaches places (such as pests at the bottom of the leaf) which are difficult to wet, the rapid absorption of the pesticide liquid is promoted, and the opportunity that the pesticide liquid contacts a target for killing is increased; the ethoxy modified polytrisiloxane has the capability of resisting rain wash, and can obviously improve the effective utilization rate of the pesticide; and the ethoxy modified polytrisiloxane is green and safe to the environment, and can effectively reduce the negative influence of the pesticide on the environment. In weak acidic and neutral environments, the polyalcohol nonionic surfactant has little influence on crops, and can effectively improve the decrement and efficiency increase effects of the pesticide.

Optionally, the auxiliary agent further comprises sodium benzoate, and the mass ratio of the active component to the sodium benzoate is 1: (0.05-0.07).

By adopting the technical scheme, the compounded pesticide is required to prevent the putrefaction and deterioration caused by microorganisms in the processes of storage and use so as to prolong the storage life of the pesticide, and therefore, a certain amount of preservative is added into the pesticide to ensure the effectiveness of the pesticide in killing pests.

In summary, the present application includes at least one of the following beneficial technical effects:

1. the insecticide takes chlorantraniliprole and spinetoram as active components, and due to the fact that different action mechanisms of the chlorantraniliprole and the spinetoram are adopted, a synergistic effect is achieved through compounding, the co-toxicity coefficient of the insecticide is increased, and the resistance development of the active components of the insecticide is effectively slowed down.

2. In the compounding process of chlorantraniliprole and spinetoram, the pesticide is controlled to be weakly acidic or neutral by using the organic acid, the degradation of active components is reduced, and the storage and use stability of the pesticide is improved.

Detailed Description

The present invention will be described in further detail with reference to examples.

In the following examples and comparative examples:

chlorantraniliprole was purchased from agriculture-Union technology development, Inc. in Beijing.

Spinetoram was purchased from Kedithua agricultural science and technology, Inc.

Ethoxy modified polytrisiloxane is available from Hubei Xinming Titai chemical Co.

The preparation method of the pesticide in the application examples and the comparative examples comprises the following steps: mixing the active components of the pesticide, all the assistants and deionized water in certain proportion, crushing, high shearing, grinding in a sand mill, and adding certain amount of organic acid to regulate pH value of the pesticide to obtain the target pesticide.

Example 1

The pesticide is characterized in that the raw materials of the pesticide are prepared into a suspending agent by the following raw materials in parts by mass:

1kg of chlorantraniliprole, 1kg of spinetoram, 3kg of deionized water, 0.177kg of polycarboxylate dispersant, 0.018kg of wetting agent sodium dodecyl sulfate and 0.005kg of ethoxy modified polytrisiloxane, and the pH value of the pesticide is adjusted to 4 by formic acid.

Example 2

An insecticide which is different from example 1 in that spinetoram is 1.5kg, and the content of the remaining components is unchanged.

Example 3

An insecticide which is different from example 1 in that spinetoram is 2kg, and the content of the remaining components is unchanged.

Example 4

An insecticide which is different from example 1 in that spinetoram is 3kg, and the content of the remaining components is unchanged.

Example 5

An insecticide which is different from example 1 in that spinetoram is 4kg, and the content of the remaining components is unchanged.

Example 6

An insecticide which differs from example 4 in that formic acid is used to adjust the pH of the insecticide to 5.

Example 7

An insecticide which differs from example 4 in that formic acid is used to adjust the pH of the insecticide to 6.

Example 8

An insecticide which differs from example 4 in that formic acid is used to adjust the pH of the insecticide to 7.

Example 9

An insecticide which is different from the insecticide of example 6 in that 0.177kg of polycarboxylate dispersant, 0.018kg of wetting agent sodium dodecyl sulfate and 0.005kg of ethoxy modified polytriasiloxane are contained in the same amount.

Example 10

An insecticide which is different from the insecticide of example 6 in that 0.154kg of polycarboxylate dispersant, 0.031kg of wetting agent sodium dodecyl sulfate and 0.015kg of ethoxy modified polytriasiloxane are contained, and the content of the rest components is unchanged.

Example 11

An insecticide which is different from the insecticide of example 6 in that 0.442kg of polycarboxylate dispersant, 0.044kg of wetting agent sodium dodecyl sulfate and 0.014kg of ethoxy modified polytriasiloxane were added, and the contents of the other components were not changed.

Example 12

The difference between the pesticide and the pesticide in example 6 is that 0.385kg of polycarboxylate dispersant, 0.077kg of wetting agent sodium dodecyl sulfate and 0.038kg of ethoxy modified polytriasiloxane, and the content of the rest components is unchanged.

Example 13

The difference between the pesticide and the pesticide in example 6 is that 0.231kg of polycarboxylate dispersant, 0.156kg of wetting agent sodium dodecyl sulfate, 0.023kg of ethoxy modified poly-trisiloxane, 0.2kg of sodium benzoate and the content of the other components is unchanged.

Example 14

The difference of the pesticide from the example 6 is that 0.169kg of polycarboxylate dispersant, 0.034kg of wetting agent sodium dodecyl sulfate, 0.017kg of ethoxy modified polytrisiloxane and 0.28kg of sodium benzoate, and the content of the other components is unchanged.

Example 15

An insecticide which is different from example 13 in that the organic acid used for adjusting the pH of the insecticide is humic acid and the remaining components are unchanged.

Example 16

An insecticide which is different from example 13 in that acetic acid is used as an organic acid for adjusting the pH of the insecticide, and the remaining components are unchanged.

Comparative example 1

An insecticide as distinguished from example 3 in that spinetoram was 5kg and the ratio of chlorantraniliprole to spinetoram was 1: 5.

Comparative example 2

An insecticide which differs from example 6 in that formic acid is used to adjust the pH of the insecticide to 3.

Comparative example 3

An insecticide which differs from example 6 in that formic acid is used to adjust the pH of the insecticide to 8.

Comparative example 1

Clear water control group.

Comparative example 2

1kg of chlorantraniliprole, 0.231kg of polycarboxylate dispersant, 0.156kg of wetting agent sodium dodecyl sulfate, 0.023kg of ethoxy modified poly trisiloxane and the pH value of the pesticide is adjusted to 5 by formic acid.

Comparative example 3

1kg of spinetoram, 0.231kg of polycarboxylate dispersant, 0.156kg of wetting agent sodium dodecyl sulfate, 0.023kg of ethoxy modified polytrisiloxane and the pH value of the pesticide is adjusted to be 5 by formic acid.

TABLE 1 Compound Mass (unit: kg) of each raw material of the insecticides of examples 1 to 13

The insecticides obtained in examples 1 to 13, comparative examples 1 to 3 and comparative examples 1 to 3 were tested.

The rice seedling soaking method is selected as a biological determination method according to the principle that two active components in the pesticide have stomach toxicity on pests. The rice stem borer was selected as the test insect. All properties were tested in triplicate and the average calculated.

The co-toxicity coefficient was calculated by the following formula:

LC_50Ais the lethal middle concentration of chlorantraniliprole; LC (liquid Crystal)_50BIs a lethal mid-concentration of spinetoram; LC (liquid Crystal)_{50 mix}Is the lethal medium concentration of the mixed preparation of chlorantraniliprole and spinetoram. P_AIs chlorantraniliproleThe proportion of formamide in the effective components of the pesticide; p_BIs the proportion of spinetoram in the effective components of the pesticide. The insect prevention effect is calculated according to the following formula:

the test results are as follows.

TABLE 2 detection of pesticide Properties

As can be seen from Table 2, in examples 1-16, when the mass ratio of chlorantraniliprole to spinetoram is 1 (1-4), the co-toxicity coefficient (CTC) of the pesticide is greater than 120, the co-toxicity coefficient shows that all the proportions have obvious synergistic effect, and the synergistic effect is shown compared with that of comparative examples 2-3, wherein when the proportion of chlorantraniliprole to spinetoram is 1:3, the synergistic effect is strongest, and the combined toxicity is strongest.

In order to investigate the effect of the pH of the pesticide on the co-toxicity coefficient of the pesticide, the pH was adjusted with formic acid. Through comparison of example 4, examples 6 to 8 and comparative examples 2 to 3, it was found that the co-toxicity coefficient of the insecticide in weak acidic and neutral environments is much larger than that in strong acidic and alkaline environments. The data of example 4 and examples 6-8 show that the co-toxicity coefficient of the insecticide in a weakly acidic environment is greater than 120, and the co-toxicity coefficient of example 6 is the largest, which indicates that the co-toxicity coefficient of the insecticide compounded by chlorantraniliprole and spinetoram is the largest and the combined toxicity is strongest when the pH is 5.

Through comparative analysis of examples 9-13 and example 6, it was found that the ratio of the various adjuvants during the compounding of the insecticide had little effect on the co-toxicity coefficient of the insecticide, which was within the range of 191-202, the remaining factors were controlled to be unchanged, the ratio of the adjuvants in the insecticide was changed, and the ratio in example 13 was the best of the measured data.

The co-toxicity coefficients of the organic acid in example 13, example 15 and example 16 are not greatly different, and are all between 200-213, showing the synergistic effect on the compound pesticide.

TABLE 3 insecticide Pest control test results

As is clear from Table 3, in comparative example 2 and comparative example 3, only one active ingredient was used, and the remaining variables were controlled, and it was found that the insecticidal effect of both insecticides was the best at 3d after administration, and the effect of the insecticide began to decrease with the lapse of time, and the insecticidal effect was decreased.

From examples 1-16, it can be seen that the insecticide compounded by chlorantraniliprole and spinetoram has good timeliness and persistence in preventing and treating rice stem borer, and the insect prevention effect is remarkably improved within 3-15 days compared with the experimental result of a single active component, which shows that the insecticide compounded by chlorantraniliprole and spinetoram has good use stability under weak acidity and neutral conditions.

The insect-proofing effect of the insecticide was analyzed by changing the kind of organic acid. In example 13 and examples 15 to 16, it can be seen that the insect-proof effects of the insecticide are not very different when the organic acid in the compounded insecticide is changed into humic acid, formic acid and acetic acid, the insect-proof effects are 92% to 94%, the good insect-proof and insect-proof effects are all shown, and the analysis of the experimental result is consistent with the analysis of the co-toxicity coefficient.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. An insecticide, characterized by: the pesticide comprises active components, an auxiliary agent, organic acid and deionized water, wherein the active components comprise chlorantraniliprole and spinetoram, and the mass ratio of the chlorantraniliprole to the spinetoram to the auxiliary agent to the deionized water is (1) - (4): (0.2-0.5): (3-6), adjusting the pH value of the pesticide to 4-7 by using an organic acid.

2. A pesticide according to claim 1, wherein: the mass ratio of the chlorantraniliprole to the spinetoram is 1 (1.5-3).

3. A pesticide according to claim 1, wherein: the organic acid adjusts the pH of the pesticide to 5-7.

4. A pesticide according to claim 1 or 3, wherein: the organic acid is one or more of humic acid, formic acid and acetic acid.

5. A pesticide according to claim 1, wherein: the auxiliary agent comprises a dispersing agent, a wetting agent and a synergist, wherein the mass ratio of the dispersing agent to the wetting agent to the synergist is 1: (0.1-0.3): (0.03-0.15).

6. A pesticide according to claim 1, wherein: the auxiliary agent comprises a dispersing agent, a wetting agent and a synergist, wherein the mass ratio of the dispersing agent to the wetting agent to the synergist is 1: (0.1-0.2): (0.04-0.09).

7. A pesticide according to claim 5 or 6, wherein: the dispersant is polycarboxylate dispersant.

8. A pesticide according to claim 5 or 6, wherein: the synergist is one or two of ethoxy modified polytrisiloxane and polyhydric alcohol type nonionic surfactant.

9. A pesticide according to claim 1, wherein: the auxiliary agent also comprises sodium benzoate, and the mass ratio of the active component to the sodium benzoate is 1: (0.05-0.07).