CN113893890B - Fractal step channel type double-emulsion micro-fluidic mass production device - Google Patents

Abstract

A fractal step channel double emulsion microfluidic mass production device, including several parallel horizontal gradual expansion-longitudinal sudden expansion emulsification units and multi-stage configuration fractal structure fluid distribution channel, the horizontal gradual expansion-longitudinal sudden expansion emulsification unit includes The interconnected equal-depth wedge-shaped flow section gradually expands and the variable-depth longitudinally suddenly expands the step structure. In the horizontal gradual expansion-longitudinal sudden expansion emulsification unit, the gradual expansion structure of the wedge-shaped flow section of equal depth pushes the fluid away from the wall of the channel, and promotes the accelerated detachment of droplets under the action of surface tension. The change of the interface Laplace pressure difference produces a directional capillary driving pressure difference, which promotes the rapid outflow of the fluid, and breaks to form droplets under the Rayleigh instability. The two effects cooperate with each other to improve the power of the emulsion. The module can promote the formation of double emulsion; the fractal structure fluid distribution channel can solve the problem of uneven distribution of each phase fluid among multiple parallel preparation units.

Description

A Fractal Step Channel Double Emulsion Microfluidic Mass Production Device

technical field

The invention relates to the technical field of double emulsion microfluidic production, in particular to a fractal step channel double emulsion microfluidic mass production device.

Background technique

Compared with single droplets, double emulsions are emulsion droplets containing smaller droplets, and there is a unique shell-core structure inside. Because of its unique flexibility and controllability, it is widely used in chemical engineering, medicine, cosmetics, etc. field. In the traditional double emulsion preparation techniques such as traditional stirring method and mechanical oscillation method, the preparation process is usually accompanied by strong oscillation and shearing. The double emulsion produced by these preparation methods has problems such as poor controllability, low sphericity, and low dispersion.

Microfluidic technology can realize the precise control of multiphase fluid and its phase interface behavior through the effective organization of multiphase fluid in tiny channels. Therefore, compared with the traditional emulsion preparation technology, the preparation of double emulsion by microfluidic technology has the advantages of good monodispersity, excellent sphericity, high controllability, etc., and the consumption of raw materials is small, and the whole preparation process is more economical and safer.

At present, the research on the single-channel microfluidic droplet generation process has been relatively mature, and high-quality, monodisperse single-, double-emulsion, and even multiple-emulsion droplets can be produced, and the droplet size, core-shell ratio, inner droplet The number can be continuously adjusted. However, in the process of mass production of double emulsions, there will be uneven distribution of the fluids of each phase among the multi-channel parallel preparation units. The droplet size will also vary, resulting in low dispersion of the double emulsion. In addition, the fluid flow of each phase in the microfluidic device is slow, which often causes "insufficient power" in the phase interface coating and detachment process at the outlet of the unit, which in turn leads to failure of emulsion formation and even channel blockage. Therefore, the uniform distribution of the fluids of each phase and the sufficient power of the droplet generation of the preparation unit are two bottlenecks in the industrial mass production of high-quality double emulsions.

Contents of the invention

The purpose of the present invention is to address the defects of the prior art and provide a fractal step channel double emulsion microfluidic mass production device that combines a wedge-shaped gradually expanding channel structure of equal depth and a step channel structure of variable depth longitudinal expansion.

In order to solve the problems of the technologies described above, the present invention provides technical solutions as follows:

A fractal step channel double emulsion microfluidic mass production device, characterized in that it includes a primary emulsification module, a secondary emulsification module, and a double emulsion delivery channel, and the primary emulsification module includes several parallel primary emulsification units , the first-stage emulsification unit includes an internal phase fluid delivery channel, a first-order equal-depth wedge-shaped flow cross-section gradual expansion structure, a first-stage variable-depth longitudinal sudden expansion step structure, and an interphase fluid delivery channel, and the internal phase fluid delivery channel The outlet is connected to the inlet of the first-level equal-depth wedge-shaped flow section gradual expansion structure, and the outlet of the first-level equal-depth wedge-shaped flow section gradual expansion structure is connected to the entrance of the first-level variable-depth longitudinal sudden expansion step structure, so The mesophase fluid delivery channel communicates with the bottom of the first-stage variable-depth longitudinal sudden expansion step structure. The second-stage emulsification module includes several parallel second-stage emulsification units. expansion structure, two-stage variable-depth longitudinal sudden expansion step structure and external fluid delivery channel, the outlet of the first-stage variable-depth longitudinal sudden expansion step structure is connected to the entrance of the second-level equal-depth wedge-shaped flow section gradual expansion structure, The outlet of the two-stage equal-depth wedge-shaped flow cross-section gradual expansion structure is connected to the inlet of the two-stage variable-depth longitudinal sudden-expansion step structure, and the external phase fluid delivery channel communicates with the bottom of the two-stage variable-depth longitudinal sudden-expansion step structure , the gradual expansion angle range of the first-level equal-depth wedge-shaped flow section gradual expansion structure and the second-level equal-depth wedge-shaped flow section gradual expansion structure is 10-35°, and the first-level variable-depth longitudinal sudden expansion step structure and the second-level The depth of the variable-depth vertical sudden expansion step structure is at least twice that of the first-level equal-depth wedge-shaped flow section gradual expansion structure and the second-level equal-depth wedge-shaped flow section gradual expansion structure. Outlet connections of the burst step structure.

Further, it also includes an internal phase fluid distribution module with a fractal structure, the internal phase fluid distribution module includes internal phase fluid main channels and internal phase fluid sub-channels connected in sequence, and the internal phase fluid main channel is bifurcated to form two The internal phase fluid sub-channel, each internal phase fluid sub-channel bifurcates to form two internal phase fluid sub-channels of the next level, until the end of the internal phase fluid distribution channel forms 2 ⁿ internal phase fluid sub-channels, n is the internal phase fluid sub-channel The fractal series of the phase fluid sub-channels is a natural number, and the nth internal phase fluid sub-channel communicates with the inlet of the internal phase fluid delivery channel.

第i-1级内相流体子通道的水力半径d_i-1与第i级内相流体子通道的水力半径d_i之间满足

其中，Δ为长度分形维数。Further, the length l _{i-1 of the internal phase fluid sub-channel of the i-1th} stage and the length l _i of the i-th internal phase fluid sub-channel satisfy

The relationship between the hydraulic radius d _{i-1 of the internal phase fluid sub-channel of the i-1th} level and the hydraulic radius d _i of the i-th internal phase fluid sub-channel satisfies

Among them, Δ is the length fractal dimension.

Further, it also includes an interphase fluid supply and distribution module with a fractal structure and an external phase fluid supply and distribution module, and the interphase fluid supply and distribution module includes an interphase fluid supply channel, an interphase fluid main channel and The mesophase fluid subchannel, the mesophase fluid main channel bifurcates to form two mesophase fluid subchannels, and each mesophase fluid subchannel bifurcates to form two mesophase fluid subchannels of the next stage, until the mesophase The end of the fluid supply distribution module forms 2 ^j mesophase fluid subchannels, j is the fractal series of mesophase fluid subchannels, and the jth stage mesophase fluid subchannel is connected to the inlet of the mesophase fluid delivery channel, so The external-phase fluid supply distribution module includes an external-phase fluid supply channel, an external-phase fluid main channel, and an external-phase fluid sub-channel connected in sequence. The external-phase fluid main channel is bifurcated to form two external-phase fluid sub-channels, and each external-phase fluid sub-channel is The bifurcation forms two external phase fluid sub-channels of the next level, until the end of the external phase fluid supply distribution module forms 2 ^k external phase fluid sub-channels, k is the fractal series of the external phase fluid sub-channels, and the k-th external phase fluid sub-channel It is connected with the inlet of the external phase fluid delivery channel, where j=k=n.

Further, the internal phase fluid distribution module, the primary emulsification module and the secondary emulsification module are all set in the channel plate, the double emulsion delivery channel is set in the cover plate, the internal phase fluid supply channel, the intermediate phase Both the liquid supply distribution module for the fluid and the liquid supply distribution module for the external phase fluid are arranged in the liquid supply bottom plate, and the cover plate, the channel plate and the liquid supply bottom plate are sequentially sealed and connected from top to bottom.

Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The horizontal gradual expansion-longitudinal sudden expansion emulsification units in the primary and secondary emulsification modules are all equal-depth wedge-shaped flow sections gradually expanded and then coupled with variable-depth longitudinal sudden expansion The step structure, in which the mid-depth wedge-shaped flow section gradually expands, can push the fluid away from the wall of the channel, and promote the accelerated detachment of droplets under the action of surface tension; the variable-depth longitudinally expanding step structure will cause the inner interface The change of the Laplace pressure difference produces a directional capillary drive pressure difference, which promotes the rapid outflow of the fluid, and breaks to form droplets under the Rayleigh instability. The two effects cooperate with each other to enhance the power of the emulsion formation. The two-stage emulsification module facilitates the formation of double emulsions. 2. In the step emulsification method, the droplet size is mainly controlled by surface/interfacial tension and is not sensitive to flow changes, so the uniformity of droplet size generated by each emulsification unit is guaranteed to the greatest extent. 3. The multi-stage configuration of the fractal structure fluid distribution channel realizes the uniform distribution and transportation of the fluid from the large runoff main flow to multiple sub-channels, and ensures the monodispersity of the droplets generated by each emulsification unit. At the same time, the distribution channel of the fractal structure can be greatly reduced. The number of syringe pumps required for mass production of droplets. 4. Add ultraviolet or heating curing device to cure the generated double emulsion into microcapsules, which can expand its application in many fields such as medicine and chemical industry.

Description of drawings

Fig. 1 is a structural representation of the present invention;

Figure 2 is a schematic diagram of the internal structure of the channel plate;

Figure 3 is a top view of the internal structure of the channel plate;

Fig. 4 is a structural schematic diagram of a primary emulsification unit and a secondary emulsification unit;

Fig. 5 is a top view of the primary emulsification unit;

Fig. 6 is a schematic diagram of the structure of the liquid supply bottom plate;

Figure 7 is a schematic diagram of the formation of double emulsion.

Among them: 1-channel plate, 2-cover plate, 3-liquid supply bottom plate, 4-internal phase fluid, 5-intermediate phase fluid, 6-single droplet, 7-external phase fluid, 8-double emulsion, 11-internal phase Fluid distribution module, 12-first-stage emulsification module, 13-secondary emulsification module, 21-double emulsion delivery channel, 31-inner phase fluid supply channel, 32-mesophase fluid supply distribution module, 33-outer phase fluid supply Distribution module, 111-main channel of internal phase fluid, 112-sub-channel of internal phase fluid, 121-transport channel of internal phase fluid, 122-first-level gradual expansion structure of wedge-shaped flow section with equal depth, 123-first-level vertical sudden expansion step with variable depth Step structure, 124-Mesophase fluid transport channel, 131-Secondary equal-depth wedge-shaped flow section gradually expanding structure, 132-Secondary variable depth longitudinal sudden expansion step structure, 133-External phase fluid transport channel, 321-Mesophase fluid main Channels, 322-intermediate fluid sub-channel, 323-intermediate fluid supply channel, 331-external phase fluid main channel, 332-external phase fluid sub-channel, 333-external phase fluid supply channel.

Detailed ways

In order to deepen the understanding of the present invention, the present invention will be further described below in conjunction with the accompanying drawings. This embodiment is only used to explain the present invention, and does not constitute a limitation to the protection scope of the present invention.

1-6 shows an embodiment of a fractal step channel type double emulsion microfluidic mass production device, including a cover plate 2, a channel plate 1 and a liquid supply bottom plate 3 that are sealed and connected from top to bottom. 2 is provided with a double emulsion delivery channel 21, an internal phase fluid distribution module 11, a primary emulsification module 12 and a secondary emulsification module 13 are provided in the channel plate 1, and an internal phase fluid supply channel is provided in the liquid supply bottom plate 3 31. The intermediate phase fluid supply and distribution module 32 and the external phase fluid supply and distribution module 33. The first-stage emulsification module 12 includes several parallel first-stage emulsification units, and the first-stage emulsification unit includes an internal phase fluid delivery channel 121, a first-stage equal-depth wedge-shaped flow section gradual expansion structure 122, a first-stage variable-depth longitudinal sudden expansion step structure 123 and The intermediate phase fluid delivery channel 124, the outlet of the inner phase fluid delivery channel 121 is connected to the inlet of the first-level equal-depth wedge-shaped flow section gradual expansion structure 122, and the outlet of the first-level equal-depth wedge-shaped flow section gradual expansion structure 122 is connected to the first-level variable-depth longitudinal The inlet of the sudden expansion step structure 123 is connected, and the interphase fluid delivery channel 124 communicates with the bottom of the first-stage variable-depth longitudinal sudden expansion step structure 123. The secondary emulsification module 13 includes several parallel secondary emulsification units, and the secondary emulsification unit includes The second-level equal-depth wedge-shaped flow cross-section gradual expansion structure 131, the second-level variable-depth vertical sudden expansion step structure 132 and the external fluid delivery channel 133, the outlet of the first-level variable-depth longitudinal sudden expansion step structure 123 and the second-level constant depth wedge-shaped flow The inlet of the cross-sectional gradually expanding structure 131 is connected, the outlet of the second-level equal-depth wedge-shaped flow section gradually expanding structure 131 is connected to the inlet of the second-level variable-depth longitudinal sudden expansion step structure 132, and the external phase fluid delivery channel 133 is connected to the second-level variable-depth longitudinal protrusion. At the bottom of the expanded step structure 132, the gradual expansion angle β of the first-level equal-depth wedge-shaped flow section gradual expansion structure 122 and the second-level equal-depth wedge-shaped flow section gradual expansion structure 131 ranges from 10 to 35°, and the first-level variable-depth longitudinal sudden expansion The depths of the step structure 123 and the second step structure 132 with variable-depth longitudinal expansion are at least twice as deep as the first-level equal-depth wedge-shaped flow section gradual expansion structure 122 and the second-level equal-depth wedge-shaped flow section gradual expansion structure 131, and the double emulsion The conveying channel 21 is connected with the outlet of the two-stage variable-depth vertical sudden expansion step structure 132 .

第i-1级内相流体子通道的水力半径d_i-1与第i级内相流体子通道的水力半径d_i之间满足

其中，Δ为长度分形维数。中间相流体供液分配模块32包括依次连接的中间相流体供液通道323、中间相流体主通道321和中间相流体子通道322，中间相流体主通道321分叉形成两个中间相流体子通道322，每个中间相流体子通道322又分叉形成下一级的两个中间相流体子通道322，直至中间相流体供液分配模块32的末端形成2^j个中间相流体子通道322，j为中间相流体子通道322的分形级数，第j级中间相流体子通道322与中间相流体输送通道124的入口连接，外相流体供液分配模块33包括依次连接的外相流体供液通道333、外相流体主通道331和外相流体子通道332，外相流体主通道331分叉形成两个外相流体子通道332，每个外相流体子通道332又分叉形成下一级的两个外相流体子通道332，直至外相流体供液分配模块33的末端形成2^k个外相流体子通道332，k为外相流体子通道332的分形级数，第k级外相流体子通道332与外相流体输送通道133的入口连接，其中j＝k＝n。The internal phase fluid distribution module 11 includes a main internal phase fluid channel 111 and an internal phase fluid subchannel 112 that are connected in sequence. The internal phase fluid main channel 111 is bifurcated to form two internal phase fluid subchannels 112, and each internal phase fluid subchannel 112 And branch to form two internal phase fluid sub-channels 112 of the next level, until the end of the internal phase fluid distribution module 11 forms ²ⁿ internal phase fluid sub-channels 112, n is the fractal series of internal phase fluid sub-channels 112, Taking a natural number, the nth internal phase fluid sub-channel 112 communicates with the inlet of the internal phase fluid delivery channel 121 . Between the length l i-1 of the internal phase fluid sub-channel of the _i-1th stage and the length l _i of the i-th internal phase fluid sub-channel satisfies

The relationship between the hydraulic radius d _{i-1 of the internal phase fluid sub-channel of the i-1th} level and the hydraulic radius d _i of the i-th internal phase fluid sub-channel satisfies

Among them, Δ is the length fractal dimension. The interphase fluid supply distribution module 32 includes an interphase fluid supply channel 323, an interphase fluid main channel 321, and an interphase fluid sub-channel 322 connected in sequence, and the interphase fluid main channel 321 is bifurcated to form two interphase fluid sub-channels 322, each mesophase fluid sub-channel 322 bifurcates to form two mesophase fluid sub-channels 322 of the next stage, until the end of the mesophase fluid supply distribution module 32 forms 2 ^j mesophase fluid sub-channels 322, j is the fractal series of the interphase fluid sub-channel 322, the j-th stage interphase fluid sub-channel 322 is connected to the inlet of the interphase fluid delivery channel 124, and the external phase fluid supply distribution module 33 includes an external phase fluid supply channel 333, which is connected in sequence, External phase fluid main channel 331 and external phase fluid sub-channel 332, external phase fluid main channel 331 bifurcates to form two external phase fluid sub-channels 332, and each external phase fluid sub-channel 332 bifurcates to form two external phase fluid sub-channels 332 of the next stage , until the end of the external-phase fluid supply distribution module 33 forms 2 ^k external-phase fluid sub-channels 332, k is the fractal series of the external-phase fluid sub-channels 332, and the k-th stage external-phase fluid sub-channel 332 is connected to the inlet of the external-phase fluid delivery channel 133 , where j=k=n.

The concrete working principle of above-mentioned embodiment is:

As shown in Figure 7, the internal phase fluid 4 flows into the internal phase fluid distribution module 11 with a fractal structure from the internal phase fluid supply channel 31, and after the intermediate phase fluid 5 is distributed through the intermediate fluid supply distribution module 32, it flows from the intermediate phase The fluid conveying channel 124 is filled with a first-level constant-depth wedge-shaped flow cross-section gradual expansion structure 122 and a first-level variable-depth longitudinal sudden expansion step structure 123 . When the internal phase fluid 4 reaches the first-stage emulsification module 12, the first-stage equal-depth wedge-shaped flow section gradual expansion structure 122 makes the front end of the internal interface between the internal phase fluid 4 and the intermediate phase fluid 5 break away from the contact with the side wall of the channel, and The interface produces centripetal contraction under the action of interfacial tension, which promotes the growth of the inner phase fluid 4 droplet SE (single emulsion). The longitudinal sudden expansion makes the front end of the inner interface grow into a bulb-shaped head with a radius of r _d , and the pressure inside the interface is p _i1 ,

Among them, p _o1 is the pressure of the interphase fluid, and γ is the interfacial tension coefficient of the water-oil two-phase.

As the neck contracts, the neck pressure is p _n1 ,

Among them, α is the contact angle between the oil phase and the solid inner wall, h is the channel height, r ₁ is the radius of curvature on the xy plane, and r ₂ is the radius of curvature on the yz plane.

The pressure in the neck and the pressure in the bulb-shaped head creates a capillary pressure difference Δp=p _n1 -p _i1 , which causes the neck to break and generate a single droplet 6 .

The generated single droplet 6 continues to flow forward along with the intermediate phase fluid 5 in the channel, and after the external phase fluid 7 is distributed by the external phase fluid supply distribution module 33, the external phase fluid delivery channel 133 is filled with the secondary equal-depth wedge-shaped flow section gradually expanding The structure 131 and the step structure 132 with two-stage variable-depth vertical sudden expansion. When the interphase fluid 5 enclosing the single droplet 6 reaches the secondary emulsification module 13, the outer interface between the interphase fluid 5 and the outer phase fluid 7 will go through a process similar to that of the inner phase fluid 4, thereby breaking and forming a double emulsion 8 .

The above-mentioned specific implementation is only to illustrate the technical concept and structural features of the present invention, and the purpose is to allow relevant persons familiar with this technology to implement it accordingly, but the above content does not limit the scope of protection of the present invention. Any equivalent change or modification made in essence shall fall within the protection scope of the present invention.

Claims (3)

1. A fractal step channel type double emulsion microfluidic mass production device, characterized in that: comprising a primary emulsification module (12), a secondary emulsification module (13) and a double emulsion delivery channel (21), said one The first-stage emulsification module (12) includes several parallel first-stage emulsification units, and the first-stage emulsification unit includes an internal phase fluid delivery channel (121), a first-stage equal-depth wedge-shaped flow section gradual expansion structure (122), a first-stage variable-depth longitudinal a sudden expansion step structure (123) and an intermediate phase fluid delivery channel (124), the outlet of the inner phase fluid delivery channel (121) is connected to the inlet of the first-level equal-depth wedge-shaped flow section gradual expansion structure (122), The outlet of the first-level constant-depth wedge-shaped flow cross-section progressive expansion structure (122) is connected to the inlet of the first-level variable-depth longitudinal sudden expansion step structure (123), and the interphase fluid delivery channel (124) communicates with a first-level The bottom of the step structure (123) with variable depth longitudinal expansion, the secondary emulsification module (13) includes several parallel secondary emulsification units, and the secondary emulsification unit includes a secondary equal-depth wedge-shaped flow section gradual expansion structure ( 131), a two-stage variable-depth vertical sudden expansion step structure (132) and an external phase fluid delivery channel (133), the outlet of the first-stage variable-depth longitudinal sudden expansion step structure (123) is connected to the second-level equal-depth wedge The inlet of the flow cross-section gradual expansion structure (131) is connected, and the outlet of the second-level equal-depth wedge-shaped flow cross-section gradual expansion structure (131) is connected with the entrance of the second-level variable depth longitudinal sudden expansion step structure (132), so The external phase fluid delivery channel (133) communicates with the bottom of the two-stage variable-depth vertical sudden expansion step structure (132), and the first-level equal-depth wedge-shaped flow section gradually expands (122) and the second-level equal-depth wedge-shaped flow section gradually expands. The gradual expansion angle β of the structure (131) ranges from 10° to 35°, and the depths of the first-level variable-depth vertically sudden expansion step structure (123) and the second-level variable-depth vertical sudden expansion step structure (132) are respectively at least The first-level equal-depth wedge-shaped flow section gradual expansion structure (122) and the second-level equal-depth wedge-shaped flow section gradual expansion structure (131) are twice as large, and the double emulsion delivery channel (21) and the second-level variable-depth longitudinal sudden expansion step The outlet connection of the structure (132); also includes an internal phase fluid distribution module (11) with a fractal structure, and the internal phase fluid distribution module (11) includes internal phase fluid main passages (111) and internal phase fluid sub-channels (111) communicated in sequence Channel (112), the internal phase fluid main channel (111) bifurcates to form two internal phase fluid sub-channels (112), and each internal phase fluid sub-channel (112) bifurcates to form two internal phase fluid sub-channels (112) of the next stage. phase fluid sub-channel until the end of the internal phase fluid distribution module (11) forms 2 ⁿ internal phase fluid sub-channels, n is the fractal series of the internal phase fluid sub-channel, which is a natural number, the nth internal phase fluid sub-channel and The inlet of the internal phase fluid delivery channel (121) is connected; it also includes an intermediate phase fluid supply distribution module (32) with a fractal structure and an external phase fluid supply distribution module (33), the intermediate phase fluid The liquid supply distribution module (32) includes an interphase fluid supply channel (323), an interphase fluid main channel (321) and an interphase fluid sub-channel (322) connected in sequence, and the interphase fluid main channel (321) is divided into The fork forms two mesophase fluid subchannels (322), and each mesophase fluid subchannel (322) forks to form two mesophase fluid subchannels of the next stage until the mesophase fluid supply distribution module (32) ^2j mesophase fluid sub-channels are formed at the end, j is the fractal series number of mesophase fluid sub-channels (322), and the jth stage mesophase fluid sub-channel is connected with the inlet of the mesophase fluid delivery channel (124), The external phase fluid supply distribution module (33) includes an external phase fluid supply channel (333), an external phase fluid main channel (331) and an external phase fluid subchannel (332) connected in sequence, and the external phase fluid main channel (331) is divided into The fork forms two external phase fluid sub-channels (332), and each external phase fluid sub-channel (332) bifurcates to form two external phase fluid sub-channels of the next stage, until the end of the external phase fluid supply distribution module (33) forms 2 ^k external phase fluid sub-channels (332), k is the fractal number of external phase fluid sub-channels (332), the kth external phase fluid sub-channel is connected with the entrance of the external phase fluid delivery channel (133), wherein j=k= n. 2. A kind of fractal step channel type double emulsion microfluidic mass production device according to claim 1, characterized in that: the length l _i-1 of the i-1th internal phase fluid sub-channel is the same as the i-th internal phase The length _l of the fluid subchannel satisfies

The relationship between the hydraulic radius d _{i-1 of the internal phase fluid sub-channel of the i-1th} level and the hydraulic radius d _i of the i-th internal phase fluid sub-channel satisfies

Among them, Δ is the length fractal dimension. 3. A kind of fractal step channel type double emulsion microfluidic mass production device according to claim 2, characterized in that: the internal phase fluid distribution module (11), the primary emulsification module (12) and the secondary emulsification module The modules (13) are all arranged in the channel plate (1), the double emulsion delivery channel (21) is arranged in the cover plate (2), the inner phase fluid supply channel (31), the middle phase fluid supply distribution The module (32) and the external phase fluid supply and distribution module (33) are both arranged in the liquid supply bottom plate (3), and the cover plate (2), the channel plate (1) and the liquid supply bottom plate (3) are sequentially arranged from top to bottom Sealed connection.

Images