CN113879705A - Storage device of mesenchymal stem cell external secret body - Google Patents
Storage device of mesenchymal stem cell external secret body Download PDFInfo
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- CN113879705A CN113879705A CN202111200714.3A CN202111200714A CN113879705A CN 113879705 A CN113879705 A CN 113879705A CN 202111200714 A CN202111200714 A CN 202111200714A CN 113879705 A CN113879705 A CN 113879705A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/10—Devices to locate articles in containers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D43/00—Lids or covers for rigid or semi-rigid containers
- B65D43/14—Non-removable lids or covers
- B65D43/20—Non-removable lids or covers linearly slidable
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of storage devices, in particular to a storage device for mesenchymal stem cell exosomes. The invention solves the problems that the existing refrigerator has a single cover opening mode, the cover and the refrigerator are connected by hinges mostly, and the refrigerator cannot be automatically closed after being turned over and opened.
Description
Technical Field
The invention relates to the technical field of storage devices, in particular to a storage device for mesenchymal stem cell exosomes.
Background
Since mesenchymal stem cell exosomes are rich in non-coding RNAs such as miRNA and the like, genes and proteins with regulating functions, sphingomyelin, cholesterol, ceramide, lipid raft domains and the like, the exosomes can resist the dissolution of non-ionic detergents at low temperature and protect the contents from degradation, and therefore, a refrigeration box is required to be used for low-temperature storage of the exosomes during storage.
Its mode of uncapping of current fridge is single, and the majority is hinge connection between case lid and the fridge, and the upset is opened the unable self-closing in back, if the case lid is opened for a long time, will seriously influence other test tubes that contain mesenchymal stem cell exosome store the constancy of temperature during, reduce mesenchymal stem cell's the storage effect.
Disclosure of Invention
The present invention is directed to a device for storing exosomes of mesenchymal stem cells, which solves the above-mentioned problems in the background.
In order to achieve the purpose, the invention adopts the following technical scheme: the utility model provides a storage device of outer secret body of mesenchymal stem cell, includes fridge and switching device, the surface of fridge is equipped with switching device, switching device is including erecting the groove, erect the groove and set up the surface at the fridge, the inside fixed mounting who erects the groove has the spring, the spring is kept away from the one end fixed mounting who erects the groove and is had the slide. The arrangement of the spring has the effect of limiting the position of the sliding plate in the vertical groove.
Preferably, the slide is kept away from the one end fixed mounting in vertical groove and is had the diaphragm, the surface of diaphragm articulates there are two hinge bars, the one end that the diaphragm was kept away from to the hinge bar articulates there is the connecting rod, logical groove has been seted up on the surface of fridge. The setting of diaphragm has played the effect that supports the hinge bar, and the setting of hinge bar has played the effect that drives the connecting rod and remove in the inside that leads to the groove.
Preferably, the surface of the refrigerating box is provided with two grooves, and a displacement plate is connected between the two grooves in a sliding manner. The arrangement of the displacement plate plays a role in driving the sliding plate to move in the vertical groove.
Preferably, the surface sliding connection of fridge has two casees, the surperficial face fixed mounting of case lid has the handle, the one end that the hinge bar was kept away from to the connecting rod passes logical groove and case lid fixed connection, the inside bottom fixed surface of fridge installs the base, a plurality of test tube standing grooves have been seted up on the surface of base. The setting of test tube standing groove has played the effect of placing the test tube, and the setting of case lid has played the effect of sealed fridge. The setting of connecting rod has played the effect that drives the case lid and remove.
Preferably, the side surface of the refrigerating box is provided with a clamping device, the clamping device comprises a sliding groove, the sliding groove is formed in the side surface of the refrigerating box, a connecting plate is connected to the inside of the sliding groove in a sliding mode, and a rack is fixedly installed at one end, far away from the sliding groove, of the connecting plate. The arrangement of the connecting plate has the effect of supporting the rack.
Preferably, it is connected with the threaded rod to rotate between the both sides inner wall of fridge, the one end port fixed mounting of threaded rod has the gear, the surperficial threaded connection of threaded rod has the movable block, the bar groove has been seted up to the inner wall of fridge, the movable block is with the help of threaded rod and bar groove sliding connection. The setting of gear has played and has driven threaded rod pivoted effect, and the setting of threaded rod has played the effect that drives the removal of movable block in bar inslot portion.
Preferably, the one end fixed mounting that the bar groove was kept away from to the movable block has a bar shaped plate, the fixed surface of bar shaped plate installs first arc clamp splice, the one end fixed surface that the bar shaped plate was kept away from to the fridge has a plurality of bracing pieces, and is a plurality of the one end fixed mounting that the fridge inner wall was kept away from to the bracing piece has second arc clamp splice. The setting of movable block has played the effect that drives the bar shaped plate and remove, and the setting of bar shaped plate has played the effect that supports first arc clamp splice, and the setting of bracing piece has played the effect that supports second arc clamp splice, and setting up of first arc clamp splice and second arc clamp splice has played the effect of fixing the test tube firmly inside the test tube standing groove.
Compared with the prior art, the invention has the advantages and positive effects that:
1. in the invention, through arranging the opening and closing device, when the refrigerating box needs to be opened and the test tube containing the mesenchymal stem cell exosome inside is taken out, the displacement plate is pushed upwards, the displacement plate moves upwards in the groove to drive the sliding plate to move upwards in the vertical groove, the sliding plate moves upwards in the vertical groove to extrude the spring, so that the spring is compressed under force and drives the transverse plate to move upwards, the transverse plate moves upwards to drive the hinge rod to move, the hinge rod moves to drive the connecting rod to slide in the through groove and further drive the two box covers to move in the direction away from each other, at the moment, the refrigerating box is in an opening and closing state, after the test tube containing the mesenchymal stem cell exosome inside the refrigerating box is taken out, when the refrigerating box needs to be closed, only the displacement plate needs to be loosened, then the transverse plate moves downwards by utilizing the resilience force of the spring, and further the two box covers move in the direction close to each other, at this moment the fridge is closed state, through the cooperation of above-mentioned structure for the case lid is opened the back, can realize automatic closed function, avoids the case lid to open for a long time, makes other storage temperature who does not take the test tube change, and then leads to the storage effect decline of test tube, reduces mesenchymal stem cell exosome's activity.
2. In the invention, by arranging the clamping device, when a test tube containing mesenchymal stem cell exosomes needs to be fixed inside the test tube placing groove, the test tube is firstly inserted into the test tube placing groove, so that the second arc-shaped clamping block clamps one end surface of the test tube, then the connecting plate is slid inside the sliding groove to drive the rack to move, the rack is moved to drive the gear to rotate, the gear is rotated to drive the threaded rod to rotate, the threaded rod is rotated to drive the movable block to move inside the strip-shaped groove, the movable block is moved inside the strip-shaped groove to drive the strip-shaped plate to move, the strip-shaped plate is moved to drive the first arc-shaped clamping block to move, the first arc-shaped clamping block is moved to enable the first arc-shaped clamping block to clamp the other end surface of the test tube, the aim of firmly fixing the test tube inside the test tube placing groove is achieved through the matching of the first arc-shaped clamping block and the second arc-shaped clamping block, through the matching of the structure, avoided when carrying the fridge, the fridge bumps with outside article, and then leads to the test tube damaged, further leads to its inside internal mesenchymal stem cell exosome to take place to damage.
Drawings
Fig. 1 is a schematic perspective view of a storage device for mesenchymal stem cell exosomes according to the present invention;
fig. 2 is a left side view schematic diagram of a storage device for mesenchymal stem cell exosomes according to the present invention;
fig. 3 is a schematic cross-sectional structural diagram of a storage device for mesenchymal stem cell exosomes according to the present invention;
fig. 4 is a schematic structural diagram of a mesenchymal stem cell exosome storage device in fig. 1 at a;
illustration of the drawings:
1. a refrigerated container; 2. a box cover; 3. a handle; 4. an opening and closing device; 41. a vertical slot; 42. a spring; 43. a slide plate; 44. a transverse plate; 45. a hinged lever; 46. a connecting rod; 47. a through groove; 48. a groove; 49. a displacement plate; 5. a clamping device; 501. a chute; 502. a connecting plate; 503. a rack; 504. a threaded rod; 505. a gear; 506. a movable block; 507. a strip-shaped groove; 508. a strip plate; 509. a first arc-shaped clamping block; 510. a support bar; 511. a second arc-shaped clamping block; 6. a base; 7. test tube standing groove.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be further described with reference to the accompanying drawings and examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
Referring to fig. 1-4, the present invention provides a technical solution: a device for storing mesenchymal stem cell exosomes comprises a refrigeration box 1 and an opening and closing device 4, wherein the opening and closing device 4 is arranged on the surface of the refrigeration box 1.
The specific arrangement and operation of the opening and closing means 4 and the clamping means 5 will be described in detail below.
In this embodiment: the opening and closing means 4 includes a vertical groove 41, the vertical groove 41 is opened on the surface of the refrigerator 1, a spring 42 is fixedly installed inside the vertical groove 41, and a sliding plate 43 is fixedly installed at one end of the spring 42 far from the vertical groove 41.
In this embodiment: the provision of the spring 42 has the effect of limiting the position of the slide plate 43 within the vertical slot 41.
Specifically, the sliding plate 43 is fixedly provided with a transverse plate 44 at one end far away from the vertical groove 41, the surface of the transverse plate 44 is hinged with two hinge rods 45, one end of each hinge rod 45 far away from the transverse plate 44 is hinged with a connecting rod 46, and the surface of the refrigeration box 1 is provided with a through groove 47.
In this embodiment: the transverse plate 44 is arranged to support the hinge rod 45, and the hinge rod 45 is arranged to drive the connecting rod 46 to move in the through groove 47.
Specifically, two grooves 48 are formed in the surface of the refrigerator 1, and a displacement plate 49 is slidably connected between the two grooves 48. The displacement plate 49 is provided to effect the sliding plate 43 to move within the vertical slot 41.
Specifically, fridge 1's surperficial sliding connection has two case lids 2, and the surperficial fixed mounting of case lid 2 has handle 3, and logical groove 47 and case lid 2 fixed connection are passed to the one end that hinge bar 45 was kept away from to connecting rod 46, and fridge 1's inside bottom fixed surface installs base 6, and a plurality of test tube standing grooves 7 have been seted up on base 6's surface. The setting of test tube standing groove 7 has played the effect of placing the test tube, and the setting of case lid 2 has played the effect of sealed fridge 1. The connecting rod 46 is arranged to bring the box cover 2 to move.
In this embodiment: clamping device 5 has been seted up to the side of fridge 1, and clamping device 5 includes spout 501, and spout 501 is seted up in the side of fridge 1, and the inside sliding connection of spout 501 has connecting plate 502, and the one end fixed mounting that connecting plate 502 kept away from spout 501 has rack 503. When a test tube containing mesenchymal stem cells is required to be fixed inside the test tube placing groove 7, the test tube is firstly inserted into the test tube placing groove 7, so that one end surface of the test tube is clamped by the second arc-shaped clamping block 511, then the connecting plate 502 is slid inside the sliding groove 501 to drive the rack 503 to move, the rack 503 is moved to drive the gear 505 to rotate, the gear 505 rotates to drive the threaded rod 504 to rotate, the threaded rod 504 rotates to drive the movable block 506 to move inside the strip-shaped groove 507, the movable block 506 moves inside the strip-shaped groove 507 to drive the strip-shaped plate 508 to move, the strip-shaped plate 508 moves to drive the first arc-shaped clamping block 509 to move, the first arc-shaped clamping block 509 moves to enable the first arc-shaped clamping block to clamp the other end surface of the test tube, and the purpose of firmly fixing the test tube inside the test tube placing groove 7 is achieved through the cooperation of the first arc-shaped clamping block 509 and the second arc-shaped clamping block 511, through the cooperation of above-mentioned structure, avoided when carrying fridge 1, fridge 1 bumps with outside article, and then leads to the test tube damaged, further leads to its inside internal mesenchymal stem cell exosome to take place to damage.
Specifically, a threaded rod 504 is rotatably connected between the inner walls of the two sides of the refrigerating box 1, a gear 505 is fixedly mounted at one end port of the threaded rod 504, a movable block 506 is connected to the surface of the threaded rod 504 in a threaded manner, a strip-shaped groove 507 is formed in the inner wall of the refrigerating box 1, and the movable block 506 is slidably connected with the strip-shaped groove 507 through the threaded rod 504.
In this embodiment: the gear 505 is arranged to drive the threaded rod 504 to rotate, and the threaded rod 504 is arranged to drive the movable block 506 to move in the strip-shaped groove 507.
Specifically, one end of the movable block 506 far away from the strip-shaped groove 507 is fixedly provided with a strip-shaped plate 508, the surface of the strip-shaped plate 508 is fixedly provided with a first arc-shaped clamping block 509, one end of the refrigerator 1 far away from the strip-shaped plate 508 is fixedly provided with a plurality of supporting rods 510, and one end of the plurality of supporting rods 510 far away from the inner wall of the refrigerator 1 is fixedly provided with a second arc-shaped clamping block 511.
In this embodiment: the setting of movable block 506 has played the effect that drives strip shaped plate 508 and remove, and the setting of strip shaped plate 508 has played the effect that supports first arc clamp splice 509, and the setting of bracing piece 510 has played the effect that supports second arc clamp splice 511, and setting up of first arc clamp splice 509 and second arc clamp splice 511 has played the effect of fixing the test tube firmly in test tube standing groove 7 inside.
The working principle is as follows: by arranging the opening and closing device 4, when the refrigerating box 1 needs to be opened and a test tube containing mesenchymal stem cell exosomes inside is taken out, the displacement plate 49 is pushed upwards, the displacement plate 49 moves upwards in the groove 48 to drive the sliding plate 43 to move upwards in the vertical groove 41, the sliding plate 43 moves upwards in the vertical groove 41 to extrude the spring 42, the spring 42 is stressed and compressed and simultaneously drives the transverse plate 44 to move upwards, the transverse plate 44 moves upwards to drive the hinge rod 45 to move, the hinge rod 45 moves to drive the connecting rod 46 to slide in the through groove 47, and further drives the two box covers 2 to move towards directions far away from each other, at the moment, the refrigerating box 1 is in an opening and closing state, after the test tube containing mesenchymal stem cell exosomes inside the refrigerating box 1 is taken out, when the refrigerating box 1 needs to be closed, only the displacement plate 49 needs to be loosened, then the resilience force of the spring 42 is utilized to enable the transverse plate 44 to move downwards, and then make two case lids 2 remove to the direction that is close to each other, at this moment fridge 1 is closed state, through the cooperation of above-mentioned structure for case lid 2 opens the back, can realize automatic closed function, avoids case lid 2 to open for a long time, makes other storage temperature that do not take the test tube change, and then leads to the storage effect decline of test tube, reduces the activity of mesenchymal stem cell exosome. When a test tube containing mesenchymal stem cells is required to be fixed inside the test tube placing groove 7, the test tube is firstly inserted into the test tube placing groove 7, so that one end surface of the test tube is clamped by the second arc-shaped clamping block 511, then the connecting plate 502 is slid inside the sliding groove 501 to drive the rack 503 to move, the rack 503 is moved to drive the gear 505 to rotate, the gear 505 rotates to drive the threaded rod 504 to rotate, the threaded rod 504 rotates to drive the movable block 506 to move inside the strip-shaped groove 507, the movable block 506 moves inside the strip-shaped groove 507 to drive the strip-shaped plate 508 to move, the strip-shaped plate 508 moves to drive the first arc-shaped clamping block 509 to move, the first arc-shaped clamping block 509 moves to enable the first arc-shaped clamping block to clamp the other end surface of the test tube, and the purpose of firmly fixing the test tube inside the test tube placing groove 7 is achieved through the cooperation of the first arc-shaped clamping block 509 and the second arc-shaped clamping block 511, through the cooperation of above-mentioned structure, avoided when carrying fridge 1, fridge 1 bumps with outside article, and then leads to the test tube damaged, further leads to its inside internal mesenchymal stem cell exosome to take place to damage.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.
Claims (7)
1. The utility model provides a storage device of mesenchymal stem cell ectosome, includes fridge (1) and switching device (4), its characterized in that: the surface of fridge (1) is equipped with switching device (4), switching device (4) are including erecting groove (41), erect groove (41) and set up on the surface of fridge (1), the inside fixed mounting who erects groove (41) has spring (42), the one end fixed mounting who erects groove (41) is kept away from in spring (42) has slide (43).
2. The device for storing exosomes of mesenchymal stem cells according to claim 1, wherein: one end fixed mounting that vertical slot (41) was kept away from in slide (43) has diaphragm (44), the surface of diaphragm (44) articulates there are two articulated rods (45), the one end that diaphragm (44) were kept away from in articulated rod (45) articulates there is connecting rod (46), logical groove (47) have been seted up on the surface of fridge (1).
3. The device for storing exosomes of mesenchymal stem cells according to claim 1, wherein: two grooves (48) are formed in the surface of the refrigerating box (1), and a displacement plate (49) is connected between the two grooves (48) in a sliding mode.
4. The device for storing exosomes of mesenchymal stem cells according to claim 1, wherein: the surperficial sliding connection of fridge (1) has two case lids (2), the surperficial fixed mounting of case lid (2) has handle (3), the one end that hinge bar (45) were kept away from in connecting rod (46) passes logical groove (47) and case lid (2) fixed connection, the inside bottom fixed surface of fridge (1) installs base (6), a plurality of test tube standing grooves (7) have been seted up on the surface of base (6).
5. The device for storing exosomes of mesenchymal stem cells according to claim 1, wherein: clamping device (5) have been seted up to the side of fridge (1), clamping device (5) include spout (501), spout (501) are seted up in the side of fridge (1), the inside sliding connection of spout (501) has connecting plate (502), the one end fixed mounting that spout (501) were kept away from in connecting plate (502) has rack (503).
6. The device for storing exosomes of mesenchymal stem cells according to claim 1, wherein: rotate between the both sides inner wall of fridge (1) and be connected with threaded rod (504), the one end port fixed mounting of threaded rod (504) has gear (505), the surperficial threaded connection of threaded rod (504) has movable block (506), bar groove (507) have been seted up to the inner wall of fridge (1), movable block (506) are with the help of threaded rod (504) and bar groove (507) sliding connection.
7. A storage device of mesenchymal stem cell exosomes according to claim 6, wherein: one end fixed mounting that bar groove (507) was kept away from in movable block (506) has bar shaped plate (508), the fixed surface of bar shaped plate (508) installs first arc clamp splice (509), the one end fixed surface that bar shaped plate (508) were kept away from in fridge (1) installs a plurality of bracing pieces (510), and is a plurality of the one end fixed mounting that fridge (1) inner wall was kept away from in bracing piece (510) has second arc clamp splice (511).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111200714.3A CN113879705B (en) | 2021-10-13 | 2021-10-13 | Storage device of mesenchymal stem cell exosome |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111200714.3A CN113879705B (en) | 2021-10-13 | 2021-10-13 | Storage device of mesenchymal stem cell exosome |
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| CN113879705A true CN113879705A (en) | 2022-01-04 |
| CN113879705B CN113879705B (en) | 2023-06-06 |
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| CN115258467A (en) * | 2022-09-29 | 2022-11-01 | 山西天茂盛环保科技有限公司 | Dangerous waste transport vehicle |
| CN117163448A (en) * | 2023-11-02 | 2023-12-05 | 青岛易而固五金汽配有限公司 | Bin convenient for storing and transporting materials |
| CN117163448B (en) * | 2023-11-02 | 2024-01-30 | 青岛易而固五金汽配有限公司 | Bin convenient for storing and transporting materials |
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| CN113879705B (en) | 2023-06-06 |
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