CN113876877A - Micro traditional Chinese medicine tablet and preparation method thereof - Google Patents
Micro traditional Chinese medicine tablet and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of release agents, in particular to a micro traditional Chinese medicine tablet and a preparation method thereof, wherein the micro traditional Chinese medicine tablet comprises the following components in parts by weight: the composition comprises 24-32 parts by weight of raw medicine, 12-20 parts by weight of filler, 5-15 parts by weight of adhesive, 4-8 parts by weight of lubricant and 2-5 parts by weight of wetting agent, wherein the raw medicine comprises 5-7 parts by weight of raw Chinese yam, 4-8 parts by weight of astragalus and 3-6 parts by weight of ginseng. The invention uses the nano-drug preparation method, can slowly release the drug, prolong the action time and achieve the aim of targeted delivery, thereby obviously improving the curative effect, reducing the toxic and side effect, improving the stability of the drug, being beneficial to storage, having the effects of strengthening the spleen, supplementing qi, nourishing the blood, clearing away the toxic materials, eliminating dampness and eliminating evil, being mainly used for improving the immunity of the organism and controlling the occurrence of opportunistic infection of AIDS and being suitable for people who have the symptoms of qi and blood deficiency of AIDS, such as general lassitude, hypodynamia, disinclination to talk, short breath, asthma, head and body pain, emaciation and easy occurrence of opportunistic infection.
Description
Technical Field
The invention relates to the technical field of release agents, and particularly relates to a micro traditional Chinese medicine tablet and a preparation method thereof.
Background
AIDS is the short term for acquired immunodeficiency syndrome, which is an infectious disease caused by human immunodeficiency virus, and has strong infectivity and high mortality. After the first case of AIDS is reported in the United states in 1981, the AIDS is rapidly spread widely in five continents worldwide, and still remains one of the most serious challenges facing the disease in the world. At present, no medicine capable of curing AIDS exists, although the number of international antiviral medicines is increased, the toxic and side effects are not reduced, and the drug resistance condition still exists, so that the treatment of AIDS is trapped in the trouble. Under such circumstances, it is important to actively take effective measures to enhance the prevention and control of opportunistic infection of AIDS, thereby reducing the fatality rate of AIDS.
In the prior art, for example, Chinese patent numbers are: CN 101773655 'an anti-AIDS nano-traditional Chinese medicine and a production method thereof', the raw materials of the effective components of the nano-traditional Chinese medicine comprise: 40-50 parts of trichosanthes root, 30-40 parts of figwort root, 30-40 parts of coptis root, 40-50 parts of scutellaria root and other dozens of traditional Chinese medicines. The production process comprises the following steps: pretreating, pulverizing, high-frequency ultrasonic pulverizing, extracting, dispersing, microwave extracting, spray drying with supersonic speed, pulverizing, nanometer grinding, mixing, encapsulating, and sterilizing. The formula has the effects of resisting virus and tumor, has no toxic or side effect, and is suitable for treating HIV, HBV and other viruses and tumor patients. The formula is subdivided into four dosage forms of morning, noon, evening and night through syndrome differentiation and treatment, pharmacodynamic analysis, medicine channel tropism, yin and yang differentiation, body resistance strengthening and evil eliminating, monarch, minister, assistant and guide reasonable compatibility and the like, and the four dosage forms are respectively taken at four hours. The medicine is applied to local skin of a human body at different time, and applied to acupuncture points to achieve transdermal absorption.
However, in the prior art, the prepared nano traditional Chinese medicine has great limitation in anti-AIDS treatment, which is only aimed at the prevention and treatment of AIDS patients in the aspect of virus or tumor, the immune system in the body of the AIDS patients is seriously damaged in the daily treatment process due to the specific pathological conditions of the AIDS patients, and the prevention and treatment scheme with great limitation can cause the patients to bear great economic, psychological and physical pressure in the treatment process, and is not beneficial to the long-term treatment of the patients.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a micro traditional Chinese medicine tablet and a preparation method thereof, the invention uses a nano medicine preparation method, can slowly release medicine, prolongs the action time, and also can achieve the aim of targeted delivery, thereby obviously improving the curative effect, reducing the toxic and side effects, improving the medicine stability, being beneficial to storage, having the effects of strengthening spleen, tonifying qi, nourishing blood, clearing away toxic materials, eliminating dampness and eliminating evil, being mainly used for improving the organism immunity function and controlling the occurrence of AIDS opportunistic infection, and being suitable for people with AIDS deficiency of both qi and blood, general fatigue, weakness, short breath, asthma, head and body pain, emaciation and easy opportunistic infection.
In order to achieve the purpose, the invention provides the following technical scheme:
a micro Chinese medicinal tablet comprises 24-32 weight parts of raw medicine, 12-20 weight parts of filler, 5-15 weight parts of adhesive, 4-8 weight parts of lubricant and 2-5 weight parts of wetting agent;
the raw medicine comprises 5-7 parts by weight of raw Chinese yam, 4-8 parts by weight of astragalus, 3-6 parts by weight of ginseng, 2-4 parts by weight of fried bighead atractylodes rhizome, 3-9 parts by weight of poria cocos, 4-6 parts by weight of Chinese angelica, 4-7 parts by weight of ligusticum wallichii, 6-10 parts by weight of white paeony root, 3-5 parts by weight of scutellaria baicalensis and 8-12 parts by weight of liquorice.
The invention is further configured to: the filler is one or more of starch, powdered sugar, dextrin, lactose and microcrystalline cellulose.
The invention is further configured to: the binder and wetting agent is one or more of syrup, hydroxypropyl methylcellulose and povidone.
The invention is further configured to: the lubricant is one or more of magnesium stearate, talcum powder, boric acid, polyethylene glycol and sodium chloride.
A preparation method of a micro traditional Chinese medicine tablet comprises the following steps:
s1, crushing and sieving the raw materials to obtain medicinal powder;
s2, mixing auxiliary materials;
and S3, drying and tabletting.
The invention is further configured to: in step S1, the method for pulverizing and sieving the raw materials to obtain the medicinal powder comprises:
s10, cleaning raw rhizoma Dioscoreae, radix astragali, radix Ginseng, parched rhizoma Atractylodis Macrocephalae, Poria, radix Angelicae sinensis, rhizoma Chuanxiong, radix Paeoniae alba, radix Scutellariae, and radix Glycyrrhizae with ultrasonic wave for 0.5-1 h;
s11, mixing the cleaned raw materials at 23-40 ℃, putting the mixture into a ball mill, and primarily grinding for 1-2h to obtain 100-200-mesh primary medicinal powder;
s12, filtering the primary powder by using a 200-mesh filter screen, and putting the particles with overlarge particle sizes into the ball mill again for grinding;
s13, placing the primary powder into a totally enclosed high-speed centrifugal shearing superfine pulverizer at 23-40 ℃ for superfine grinding for 3-5h to obtain nanometer powder with particle size of below 200 nm;
s14, putting the nanometer powder into a filter screen with more than 360 meshes for filtering, and putting the powder with larger particle size into a totally enclosed high-speed centrifugal shear superfine pulverizer for superfine grinding.
The invention is further configured to: in step S2, the method of mixing the auxiliary materials includes:
s20, preparing an auxiliary material mixed solution;
s21, adding the nanometer medicinal powder to obtain nanometer mixed solution;
and S22, adding the nanometer mixed solution into a gravity-free mixer, and uniformly stirring.
The invention is further configured to: in the step S20, in the above step,
s201, putting the filler, the adhesive, the lubricant and the wetting agent into a ball mill, grinding into auxiliary material powder, and filtering by using a 200-mesh filter screen;
s202, mixing the auxiliary material powder with clear water according to a weight ratio of 1: 4, mixing to obtain an auxiliary material mixed solution.
The invention is further configured to: in the step S3, the nanosuspension is uniformly spread in a receiving mold, and then dried at 95-100 ℃ for 1-2h to obtain tablet powder, and the receiving mold containing the tablet powder is placed under a punch to perform punching and tabletting, so as to obtain the finished product of the micro traditional Chinese medicine tablet.
Advantageous effects
Compared with the known public technology, the technical scheme provided by the invention has the following beneficial effects:
according to the micro traditional Chinese medicine tablet prepared by the invention, through data observation of contrast experiments in performance detection, the clinical common symptoms of AIDS such as fever, hypodynamia, diarrhea, cough and the like of a patient taking the micro traditional Chinese medicine tablet are obviously improved, the occurrence frequency of common opportunistic infection of the patient is obviously reduced, the weight of the patient is recovered and increased to different degrees, most of the patients recover the labor capacity, the immune function is obviously improved, the actual measured value of the virus load of the patient is also in a year-by-year descending situation, and the overall annual fatality rate is reduced and is in a year-by-year descending trend. The micro traditional Chinese medicine tablet has the effects of strengthening spleen, tonifying qi, nourishing blood, clearing toxin, eliminating dampness and eliminating evil, is mainly used for improving the immune function of an organism and controlling the occurrence of opportunistic infection of AIDS, and is suitable for people with deficiency of both qi and blood of AIDS, general lassitude, shortness of breath, asthma, head and body pain, body emaciation and opportunistic infection which are easy to occur.
Description of the drawings:
FIG. 1 is a table showing the fatality rate of the micro-Chinese medicinal tablets in the control experiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present invention will be further described with reference to the following examples.
Example 1
A micro traditional Chinese medicine tablet comprises 32 parts by weight of raw medicine, 20 parts by weight of filler, 15 parts by weight of adhesive, 8 parts by weight of lubricant and 5 parts by weight of wetting agent, wherein the raw medicine comprises 7 parts by weight of raw Chinese yam, 8 parts by weight of astragalus, 6 parts by weight of ginseng, 4 parts by weight of fried bighead atractylodes rhizome, 9 parts by weight of poria cocos, 6 parts by weight of Chinese angelica, 7 parts by weight of ligusticum wallichii, 10 parts by weight of white paeony root, 5 parts by weight of scutellaria baicalensis and 12 parts by weight of liquorice, the filler is one or more of starch, powdered sugar, dextrin, lactose and microcrystalline cellulose, the adhesive and the wetting agent are one or more of syrup, hydroxypropyl methylcellulose and povidone, and the lubricant is one or more of magnesium stearate, talcum powder, boric acid, polyethylene glycol and sodium chloride.
A preparation method of a micro traditional Chinese medicine tablet comprises the following steps:
step one, crushing and sieving raw materials to obtain medicinal material powder:
10) cleaning rhizoma Dioscoreae, radix astragali, Ginseng radix, parched Atractylodis rhizoma, Poria, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae alba, Scutellariae radix and Glycyrrhrizae radix with ultrasonic for 1 hr.
11) Mixing the cleaned raw materials at 23-40 deg.C, putting into a ball mill, and primarily grinding for 1-2h to obtain 100-200 mesh primary medicinal powder.
12) The primary powder was filtered using a 200 mesh sieve, and the particles having an excessively large particle size were put into the ball mill again to be ground.
13) Placing the primary medicinal powder into a totally enclosed high-speed centrifugal shear superfine pulverizer at 23-40 deg.C, and performing superfine grinding for 5 hr to obtain nanometer medicinal powder with particle diameter of below 200 nm.
14) Filtering with a filter screen of 360 mesh or more, and grinding with a closed high-speed centrifugal shear superfine pulverizer.
Step two, mixing auxiliary materials:
20) preparing an auxiliary material mixed solution:
201) putting the filler, the adhesive, the lubricant and the wetting agent into a ball mill, grinding into auxiliary material powder, and filtering by using a 200-mesh filter screen;
202) mixing auxiliary material powder and clear water according to a weight ratio of 1: 4, mixing to obtain an auxiliary material mixed solution.
21) Adding the nanometer medicinal powder to obtain nanometer mixed solution.
22) And (4) putting the nano mixed solution into a gravity-free mixer and uniformly stirring.
Step three, drying and tabletting: uniformly spreading the nanometer suspension in a receiving mold, drying at 95-100 deg.C for 1-2 hr to obtain tablet powder, and placing the receiving mold containing the tablet powder under a punch to perform punching and tabletting to obtain final product micro Chinese medicinal tablet.
The nano-drug preparation method is used in the preparation process of the micro-traditional Chinese medicine tablet, so that the drug can be slowly released, the action time is prolonged, and the target delivery can be achieved, thereby obviously improving the curative effect, reducing the toxic and side effects, improving the drug stability and being beneficial to storage.
Performance testing
The detection method of the micro traditional Chinese medicine tablet prepared in the example 1 is as follows:
the micro traditional Chinese medicine tablets are matched with traditional Chinese medicine for dialectical treatment to observe HIV/AIDS patients for 48 months, and the results of the observation show that the patients before and after treatment have fever, cough, hypodynamia, diarrhea, vomiting, spontaneous perspiration, night sweat, skin itch, rash, mucosal ulcer, herpes, lymphadenectasis and the total integral of symptom signs are recorded as table 1.
TABLE 1 integral comparison table of symptom and sign before and after treatment of patients
Injection, P < 0.01 compared to before treatment
Patient charpy score, weight data after treatment are recorded as table 2.
TABLE 2 card-type score, weight and number of cold comparison table before and after treatment
Note: p < 0.01 compared to before treatment
The micro traditional Chinese medicine tablets were used for 168 days of treatment of 160 cases of HIV/AIDS patients, and the results of the micro traditional Chinese medicine tablets on hypodynamia, shortness of breath, spontaneous perspiration, emaciation, general pain and rash were recorded in Table 3.
TABLE 3 comparison of the effects on the chief complaints and signs before and after treatment
Note: p < 0.05, P < 0.01, compared to pre-treatment.
The micro traditional Chinese medicine tablets are adopted to treat 168 days of 160 cases of HIV/AIDS patients, and the 30 days before treatment is compared with the last 30 days of treatment, so that the incidence rate of upper respiratory tract infection, lung infection, diarrhea and other events is obviously reduced after 30 days after treatment, and the difference before and after treatment is recorded as table 4.
TABLE 4 comparison table of opportunistic interference before and after treatment for AIDS patients
The retrospective clinical analysis study of 3229 cases of treatment with and without the micro-traditional Chinese medicine tablets showed 2.97% annual mortality rate of the micro-traditional Chinese medicine tablets, 3.79% annual mortality rate of the non-micro-traditional Chinese medicine tablets, and a difference between the two groups of 8-year cumulative mortality rates of 4.5%, which is recorded in fig. 1.
According to the micro traditional Chinese medicine tablet prepared by the invention, through data observation of contrast experiments in performance detection, the clinical common symptoms of AIDS such as fever, hypodynamia, diarrhea, cough and the like of a patient taking the micro traditional Chinese medicine tablet are obviously improved, the occurrence frequency of common opportunistic infection of the patient is obviously reduced, the weight of the patient is recovered and increased to different degrees, most of the patients recover the labor capacity, the immune function is obviously improved, the actual measured value of the virus load of the patient is also in a year-by-year descending situation, and the overall annual fatality rate is reduced and is in a year-by-year descending trend. The micro traditional Chinese medicine tablet has the effects of strengthening spleen, tonifying qi, nourishing blood, clearing toxin, eliminating dampness and eliminating evil, is mainly used for improving the immunity of the organism and controlling the occurrence of opportunistic infection of AIDS and is suitable for people with AIDS deficiency of qi and blood, general lassitude, shortness of breath, asthma, head and body pain, body wasting and easy opportunistic infection.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (9)
1. A micro traditional Chinese medicine tablet is characterized by comprising 24-32 parts by weight of raw medicine, 12-20 parts by weight of filler, 5-15 parts by weight of adhesive, 4-8 parts by weight of lubricant and 2-5 parts by weight of wetting agent;
the raw medicine comprises 5-7 parts by weight of raw Chinese yam, 4-8 parts by weight of astragalus, 3-6 parts by weight of ginseng, 2-4 parts by weight of fried bighead atractylodes rhizome, 3-9 parts by weight of poria cocos, 4-6 parts by weight of Chinese angelica, 4-7 parts by weight of ligusticum wallichii, 6-10 parts by weight of white paeony root, 3-5 parts by weight of scutellaria baicalensis and 8-12 parts by weight of liquorice.
2. The micro traditional Chinese medicine tablet of claim 1, wherein the filler is one or more of starch, powdered sugar, dextrin, lactose and microcrystalline cellulose.
3. The micro traditional Chinese medicine tablet of claim 1, wherein the binder and wetting agent is one or more of syrup, hydroxypropyl methylcellulose and povidone.
4. The micro traditional Chinese medicine tablet according to claim 1, wherein the lubricant is one or more of magnesium stearate, talc, boric acid, polyethylene glycol and sodium chloride.
5. A method for preparing a micro-traditional Chinese medicine tablet, which is characterized by using the micro-traditional Chinese medicine tablet according to any one of claims 1 to 4, and comprises the following steps:
s1, crushing and sieving the raw materials to obtain medicinal powder;
s2, mixing auxiliary materials;
and S3, drying and tabletting.
6. The method for preparing the micro traditional Chinese medicine tablet according to claim 5, wherein in the step S1, the method for obtaining the medicinal powder by crushing and sieving the raw materials comprises the following steps:
s10, cleaning raw rhizoma Dioscoreae, radix astragali, radix Ginseng, parched rhizoma Atractylodis Macrocephalae, Poria, radix Angelicae sinensis, rhizoma Chuanxiong, radix Paeoniae alba, radix Scutellariae, and radix Glycyrrhizae with ultrasonic wave for 0.5-1 h;
s11, mixing the cleaned raw materials at 23-40 ℃, putting the mixture into a ball mill, and primarily grinding for 1-2h to obtain 100-200-mesh primary medicinal powder;
s12, filtering the primary powder by using a 200-mesh filter screen, and putting the particles with overlarge particle sizes into the ball mill again for grinding;
s13, placing the primary powder into a totally enclosed high-speed centrifugal shearing superfine pulverizer at 23-40 ℃ for superfine grinding for 3-5h to obtain nanometer powder with particle size of below 200 nm;
s14, putting the nanometer powder into a filter screen with more than 360 meshes for filtering, and putting the powder with larger particle size into a totally enclosed high-speed centrifugal shear superfine pulverizer for superfine grinding.
7. The method for preparing the micro traditional Chinese medicine tablet according to claim 6, wherein in the step S2, the method for mixing the auxiliary materials comprises the following steps:
s20, preparing an auxiliary material mixed solution;
s21, adding the nanometer medicinal powder to obtain nanometer mixed solution;
and S22, adding the nanometer mixed solution into a gravity-free mixer, and uniformly stirring.
8. The method for preparing a micro Chinese medicinal tablet according to claim 6, wherein in the step S20,
s201, putting the filler, the adhesive, the lubricant and the wetting agent into a ball mill, grinding into auxiliary material powder, and filtering by using a 200-mesh filter screen;
s202, mixing the auxiliary material powder with clear water according to a weight ratio of 1: 4, mixing to obtain an auxiliary material mixed solution.
9. The method of claim 5, wherein in step S3, the nanosuspension is uniformly spread in a receiving mold, and then dried at 95-100 ℃ for 1-2h to obtain tablet powder, and the receiving mold containing the tablet powder is placed under a punch to perform tabletting, thereby obtaining the final product of the micro Chinese medicinal tablet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114470076A (en) * | 2022-02-28 | 2022-05-13 | 重庆科瑞制药(集团)有限公司 | Dizzy-eliminating and dizziness-stopping tablet and preparation method thereof |
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