CN113874025A - 用于抑制hmgb1表达的组合物和方法 - Google Patents

用于抑制hmgb1表达的组合物和方法 Download PDF

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Publication number
CN113874025A
CN113874025A CN201980093263.2A CN201980093263A CN113874025A CN 113874025 A CN113874025 A CN 113874025A CN 201980093263 A CN201980093263 A CN 201980093263A CN 113874025 A CN113874025 A CN 113874025A
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seq
oligonucleotide
antisense strand
sequence
sense strand
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Chinese (zh)
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M·阿布拉姆斯
G·乔普达
朴智慧
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Novo Nordisk AS
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Dicerna Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980093263.2A 2018-12-28 2019-12-20 用于抑制hmgb1表达的组合物和方法 Withdrawn CN113874025A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862786287P 2018-12-28 2018-12-28
US62/786287 2018-12-28
US201862787038P 2018-12-31 2018-12-31
US62/787038 2018-12-31
US201962788111P 2019-01-03 2019-01-03
US62/788111 2019-01-03
PCT/US2019/067883 WO2020139764A1 (en) 2018-12-28 2019-12-20 Compositions and methods for inhibiting hmgb1 expression

Publications (1)

Publication Number Publication Date
CN113874025A true CN113874025A (zh) 2021-12-31

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CN201980093263.2A Withdrawn CN113874025A (zh) 2018-12-28 2019-12-20 用于抑制hmgb1表达的组合物和方法

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US (1) US20220072024A1 (https=)
EP (1) EP3883581A4 (https=)
JP (2) JP2022517742A (https=)
KR (1) KR20210126004A (https=)
CN (1) CN113874025A (https=)
AU (1) AU2019417585A1 (https=)
BR (1) BR112021012516A2 (https=)
CA (1) CA3124664A1 (https=)
CL (2) CL2021001718A1 (https=)
IL (2) IL284327B2 (https=)
MX (1) MX2021007855A (https=)
SG (1) SG11202106857VA (https=)
WO (1) WO2020139764A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023208023A1 (zh) * 2022-04-26 2023-11-02 上海拓界生物医药科技有限公司 氘代化学修饰和包含其的寡核苷酸

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200023427A (ko) 2017-06-29 2020-03-04 다이서나 파마수이티컬, 인크. Hmgb1 발현을 억제하기 위한 조성물 및 방법
TWI868755B (zh) 2022-06-24 2025-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
CN117264954A (zh) * 2022-09-20 2023-12-22 北京福元医药股份有限公司 用于抑制hmgb1基因表达的双链核糖核酸及其修饰物、缀合物和用途
WO2024233864A2 (en) * 2023-05-10 2024-11-14 Dicerna Pharmaceuticals, Inc. Galnac-conjugated rnai oligonucleotides

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WO2007150071A1 (en) * 2006-06-23 2007-12-27 Myriad Genetics, Inc. Gene amplifications and deletions

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WO2007076200A2 (en) * 2005-11-28 2007-07-05 Medimmune, Inc. Antagonists of hmgb1 and/or rage and methods of use thereof
US9278108B2 (en) * 2009-07-16 2016-03-08 Nec Solution Innovators, Ltd. HMGB1 binding nucleic acid molecule and applications thereof
WO2012036215A1 (ja) * 2010-09-17 2012-03-22 Taniguchi Tadatsugu Ｈｍｇｂタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法
WO2012177639A2 (en) * 2011-06-22 2012-12-27 Alnylam Pharmaceuticals, Inc. Bioprocessing and bioproduction using avian cell lines
AU2015330670B2 (en) * 2014-10-10 2022-01-06 Novo Nordisk Health Care Ag Therapeutic inhibition of lactate dehydrogenase and agents therefor
JP7105065B2 (ja) * 2014-12-15 2022-07-22 ダイセルナ ファーマシューティカルズ， インコーポレイテッド リガンド修飾二本鎖核酸
WO2017079227A1 (en) * 2015-11-05 2017-05-11 University Of Connecticut Compositions and methods for the treatment of liver fibrosis
KR102350647B1 (ko) * 2016-09-02 2022-01-14 다이서나 파마수이티컬, 인크. 4'-포스페이트 유사체 및 이를 포함하는 올리고뉴클레오타이드
KR20200023427A (ko) * 2017-06-29 2020-03-04 다이서나 파마수이티컬, 인크. Hmgb1 발현을 억제하기 위한 조성물 및 방법
JP2021508491A (ja) * 2017-12-18 2021-03-11 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 高移動度グループボックス−１（ＨＭＧＢ１）ｉＲＮＡ組成物及びその使用方法

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Publication number Priority date Publication date Assignee Title
WO2007150071A1 (en) * 2006-06-23 2007-12-27 Myriad Genetics, Inc. Gene amplifications and deletions

Non-Patent Citations (2)

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Title
WEI JIANG等: "Reduced High-Mobility Group Box 1 Expression Induced by RNA Interference Inhibits the Bioactivity of Hepatocellular Carcinoma Cell Line HCCLM3", 《DIGESTIVE DISEASES AND SCIENCES》, vol. 57, 26 October 2011 (2011-10-26), pages 92 - 98, XP055570668, DOI: 10.1007/s10620-011-1944-z *
李芳等: "高迁移率族蛋白B1与肿瘤相关性的研究进展", 医学综述, vol. 14, no. 18, 30 September 2008 (2008-09-30), pages 2777 - 2780 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023208023A1 (zh) * 2022-04-26 2023-11-02 上海拓界生物医药科技有限公司 氘代化学修饰和包含其的寡核苷酸

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MX2021007855A (es) 2021-10-26
CA3124664A1 (en) 2020-07-02
SG11202106857VA (en) 2021-07-29
EP3883581A4 (en) 2023-03-29
KR20210126004A (ko) 2021-10-19
WO2020139764A1 (en) 2020-07-02
CL2023002984A1 (es) 2024-03-08
CL2021001718A1 (es) 2022-02-18
IL284327A (en) 2021-08-31
IL313425A (en) 2024-08-01
US20220072024A1 (en) 2022-03-10
IL284327B2 (en) 2024-11-01
EP3883581A1 (en) 2021-09-29
BR112021012516A2 (pt) 2021-09-14
IL284327B1 (en) 2024-07-01
AU2019417585A1 (en) 2021-07-08
JP2024105308A (ja) 2024-08-06
JP2022517742A (ja) 2022-03-10

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