CN113866401B - One minute quick poison detection device - Google Patents

One minute quick poison detection device Download PDF

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Publication number
CN113866401B
CN113866401B CN202111178163.5A CN202111178163A CN113866401B CN 113866401 B CN113866401 B CN 113866401B CN 202111178163 A CN202111178163 A CN 202111178163A CN 113866401 B CN113866401 B CN 113866401B
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detection
shell
test paper
slot
sampler
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CN113866401A (en
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金伟
王海林
刘洋
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Wuhan Nano Diagnosis For Health Biotechnology Co ltd
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Wuhan Nano Diagnosis For Health Biotechnology Co ltd
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Priority to CN202111178163.5A priority Critical patent/CN113866401B/en
Publication of CN113866401A publication Critical patent/CN113866401A/en
Priority to PCT/CN2022/119591 priority patent/WO2023056837A1/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Abstract

The invention relates to the technical field of drug detection, and in particular discloses a one-minute rapid drug detection device, which comprises: the plug-in type poison detection card comprises a sampler for acquiring a sample to be detected, a shell connected with the sampler in a plug-in manner and detection test paper positioned in the shell; the detection test paper is used for reacting with the sample to be detected; the portable terminal is detachably connected with the pluggable poison detection card and is used for acquiring the visual change condition of the detection test paper and generating a detection result according to the visual change condition. The one-minute rapid toxicity detection device provided by the invention can effectively solve the problems that the detection time is too long and the detection is easy to occur careless by naked eyes in the prior art.

Description

One minute quick poison detection device
Technical Field
The invention relates to the technical field of drug detection, in particular to a one-minute rapid drug detection device.
Background
The traditional poison detection device generally comprises a shell and detection test paper positioned in the shell, one end of the shell is provided with a through hole, a person to be detected contains one end of the traditional poison detection device provided with the through hole in the mouth for a period of time, saliva can infiltrate the detection test paper through the through hole, and if the poison content in the saliva exceeds the standard, the detection test paper can change color.
On the one hand, due to the structural design of the traditional poison detection device, the person to be detected generally needs to contain the traditional poison detection device in the mouth for 3 minutes to collect enough saliva samples for the reaction of the detection test paper, and the conditions of dissatisfaction or traffic jam and the like of the person to be detected are easily caused due to overlong sample collection time, so that the general detection work is difficult to rise;
on the other hand, the supervision personnel judges the visual effect change condition of the detection test paper by means of naked eye observation, and the careless mistakes easily occur under emergency.
Therefore, improvement on the traditional poison detection device is needed to solve the problems that the detection time is too long and the detection is easy to occur due to careless mistakes by naked eyes.
The above information disclosed in this background section is only included to enhance understanding of the background of the disclosure and therefore may contain information that does not form the prior art that is presently known to those of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a one-minute rapid poison detection device which can effectively solve the problems that the detection time of the traditional poison detection device is too long and the poison detection device is easy to be careless by naked eyes.
To achieve the above object, the present invention provides a one-minute rapid poison detection apparatus comprising:
the plug-in type poison detection card comprises a sampler for acquiring a sample to be detected, a shell connected with the sampler in a plug-in manner and detection test paper positioned in the shell; the detection test paper is used for reacting with the sample to be detected;
the portable terminal is detachably connected with the pluggable poison detection card and is used for acquiring the visual change condition of the detection test paper and generating a detection result according to the visual change condition.
Optionally, an end slot is provided on a surface of the portable terminal, and the plug-in type poison detection card is connected with the end slot in a plug-in connection manner.
Optionally, the shell is provided with an observation window for observing the visual effect change of the detection test paper;
and an information acquisition unit for acquiring the visual effect change is arranged at the position corresponding to the observation window in the end slot.
Optionally, the information acquisition unit is a fluorescence sensor or an image sensor.
Optionally, the portable terminal is further provided with:
the data processing unit is connected with the information acquisition unit and is used for processing the data acquired by the information acquisition unit and generating the detection result;
and the terminal output device is electrically connected with the data processing unit and is used for providing display of at least one of information of pictures, characters, videos, sounds or lights for the supervisory personnel according to the detection result.
Alternatively to this, the method may comprise,
a detection cavity for storing the detection test paper is formed in the shell, and a shell slot communicated with the detection cavity is formed in the end face of one end of the shell;
the sampler comprises a fiber bundle connected with the shell slot in a plugging manner and a handheld part fixed at one end of the fiber bundle far away from the shell; the other end of the fiber bundle is used for acquiring the sample to be detected.
Optionally, a tilting channel which is obliquely extended to enable the detection cavity to be communicated with the shell slot is arranged at the bottom of the shell slot;
one end of the test paper penetrates through the inclined channel and stretches into the shell slot.
Optionally, a first limiting boss is fixedly arranged in the shell slot, and a clamping plate is arranged outside the sampler;
when the sampler is inserted into the shell slot, the first limiting boss abuts against the clamping plate so as to limit the continued insertion of the sampler.
Optionally, a second limiting boss is arranged on one side, away from the detection test paper, of the first limiting boss; the second limiting boss is provided with a plate passing notch;
the outside of sampler is equipped with can pass the board breach gets into cardboard in the spacing clearance between first spacing boss and the spacing boss of second.
Optionally, an extrusion boss for extruding the fiber bundle is further arranged at the bottom of the shell slot
The invention has the beneficial effects that: on one hand, the sampler can be directly pulled out of the inlet to obtain a sample to be detected and then reinserted into the shell, so that the sample to be detected is directly contacted with the detection test paper, and the obtaining time of the sample to be detected is effectively shortened; on the other hand, the visual effect change of the detection test paper is automatically judged by using the portable terminal, so that the dependence on manpower is reduced, the accuracy of the detection result is improved, and the misjudgment risk is reduced.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the invention, and that other drawings can be obtained from these drawings without inventive faculty for a person skilled in the art.
FIG. 1 is a schematic diagram of a one minute rapid toxicity test apparatus according to an embodiment;
FIG. 2 is a schematic cross-sectional view of a plug-in poison detection card according to an embodiment;
FIG. 3 is a schematic top view of a lower shell provided in an embodiment;
fig. 4 is a schematic illustration of the insertion of the sampler and the housing provided in the embodiment.
In the figure:
100. a plug-in type poison detection card; 200. a portable terminal;
1. a housing; 101. an upper case; 1011. an observation window; 102. a lower case; 1021. a test paper groove; 1022. a drainage baffle; 103. a detection chamber; 104. a shell slot; 105. the first limiting boss; 106. extruding the boss; 107. an inclined channel; 108. the second limiting boss; 1081. a board passing notch; 109. a buffer space;
2. a sampler; 201. a fiber bundle; 202. a hand-held part; 203. a clamping plate;
3. detecting test paper;
4. an information acquisition unit;
5. a data processing unit;
6. an end output device;
7. and an end slot.
Detailed Description
In order to make the objects, features and advantages of the present invention more obvious and understandable, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is apparent that the embodiments described below are only some embodiments of the present invention, not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it will be understood that when one component is referred to as being "connected" to another component, it can be directly connected to the other component or intervening components may also be present. When an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present.
Furthermore, the terms "long," "short," "inner," "outer," and the like, as used herein, refer to an orientation or positional relationship based on that shown in the drawings, for convenience of description of the present invention, and are not intended to indicate or imply that the apparatus or elements referred to must have this particular orientation, operate in a particular orientation configuration, and thus should not be construed as limiting the invention.
The present invention will be described in detail below with reference to specific embodiments shown in the drawings. These embodiments are not intended to limit the invention and structural, methodological, or functional modifications of these embodiments that may be made by one of ordinary skill in the art are included within the scope of the invention.
The invention provides a one-minute rapid toxicity detection device which is suitable for application scenes of taking toxicity to detected personnel by supervisory personnel, on one hand, sampling and reaction time can be greatly shortened, and further detection time is shortened; on the other hand, automatic judgment of the detection result is realized through the portable terminal, and the risk of misjudgment is reduced.
Referring to fig. 1, the one-minute rapid poison detection apparatus provided in the present embodiment includes a plug-in poison detection card 100 and a portable terminal 200.
Referring to fig. 2, the plug-in poison detection card 100 includes a sampler 2 for obtaining a sample to be detected, a housing 1 connected with the sampler 2 in a plug-in manner, and a detection test paper 3 located in the housing 1; the test paper 3 is used for reacting with the sample to be detected. The portable terminal 200 is detachably connected with the pluggable poison detection card 100, and is used for obtaining the visual change condition of the detection test paper 3 and generating a detection result according to the visual change condition.
Further, a detection cavity 103 for placing the detection test paper 3 is arranged inside the shell 1, and a shell slot 104 communicated with the detection cavity 103 through an inclined channel 107 is arranged on the end face of one end of the shell 1. Optionally, the housing 1 includes an upper shell 101 and a lower shell 102 that are connected by a snap, and after the upper shell 101 and the lower shell 102 are fastened, the detection cavity 103, the inclined channel 107, and the shell slot 104 may be formed inside the upper shell and the lower shell. Further, the upper case 101 is provided with an observation window 1011.
The test paper 3 is located in the detection cavity 103 and is used for reacting with the sample to be detected. For example, the test strip 3 may be a reaction test strip containing fluorescent nanoparticles or a colloidal gold test strip 3, and after the test strip 3 reacts with a sample to be tested having an exceeding toxicity, a change in visual effects such as fluorescence or color change occurs. The change in visual effect of the test paper 3 can be observed through the observation window 1011. Wherein the drug may be opioid, heroin, methamphetamine (methamphetamine), morphine, marijuana, cocaine, and other narcotics and psychotropic drugs regulated by national regulations that cause a person to become craving.
The sampler 2 comprises a fiber bundle 201 connected with the shell slot 104 in a plug-in way and a hand-held part 202 fixed at one end of the fiber bundle 201 far away from the shell 1. Wherein, the surface of the hand-holding part 202 is provided with an anti-slip boss. Further, the anti-slip boss is a dot protruding from the surface of the hand-held portion 202.
An end slot 7 is provided on a surface of the portable terminal 200, and the plug-in type poison detection card 100 is connected with the end slot 7 in a plug-in type manner. An information acquisition unit 4 for acquiring the visual effect change is arranged at a position corresponding to the observation window 1011 in the end slot 7. Optionally, the information collecting unit 4 is a fluorescence sensor or an image sensor. Further, the portable terminal 200 is also provided with a data processing unit 5 and an end output device 6. The data processing unit 5 is connected with the information acquisition unit 4, and is configured to process the data acquired by the information acquisition unit 4 and generate the detection result. The terminal output device 6 is electrically connected with the data processing unit 5, and is configured to provide display of at least one of information including pictures, characters, videos, sounds or lights for a supervisory personnel according to the detection result. Accordingly, the end output means 6 may comprise at least one of a display screen, a buzzer or a flashing light.
Optionally, the size of the portable terminal 200 is similar to that of a mobile phone, and the portable terminal is convenient to carry.
The working process of the plug-in poison detection card 100 provided in this embodiment is as follows:
(1) the supervisory personnel pulls out the plug-in type poison detection card 100 from the terminal slot 7, and then puts the portable terminal 200 into a pocket; subsequently, holding the housing 1 with one hand and pinching the hand-held portion 202 of the sampler 2 with the other hand, extracting the sampler 2 from the housing slot 104, and then placing the other end of the fiber bundle 201 into the mouth of the person to be inspected; the water absorption capacity of the fiber bundle 201 is super strong, so that saliva of a person to be detected can be fully soaked in a few seconds, namely, saliva of the person to be detected is fully soaked in the fiber bundle 201, the person to be detected opens a mouth, and a supervisor takes out the fiber bundle 201, so that the sample to be detected can be obtained;
(2) the supervisor inserts the fiber bundle 201 into the shell slot 104, and then inserts the pluggable poison detection card 100 back into the end slot 7;
(3) the sample to be detected carried by the fiber bundle 201 enters the detection cavity 103 through the inclined channel 107 and reacts with the detection test paper 3 in the detection cavity 103;
(4) the information acquisition unit 4 captures the visual effect change information of the detection test paper 3 through the observation window 1011, and transmits the captured data to the data processing unit 5, the data processing unit 5 processes the data, then the detection result is displayed in a picture-text mode through the end output device 6, and the supervisor can know whether the drug is absorbed by the person to be detected through the end output device 6.
The pluggable poison detection card 100 provided by the embodiment uses the fiber bundle 201 to directly take the sample to be detected, then sends the sample to be detected into the detection cavity 103 to react with the detection test paper 3, greatly improves the acquisition speed of the sample to be detected, further effectively shortens the detection time and reduces the difficulty of general detection work.
Alternatively, the fiber bundle 201 is made of a hydrophilic material, which not only has good liquid absorbing performance, but also can be bent and deformed when being pressed, so that the sucked sample to be detected is extruded.
In this embodiment, the fiber bundle 201 is made of ultra-fine natural fibers and/or ultra-fine synthetic fibers. For example, the ultrafine natural fibers may be animal fibers (spider silk, animal fluff), plant fibers (cotton, etc.), or the like; the superfine synthetic fiber can be hydrophilic polyester, hydrophilic polyamide, hydrophilic polyacrylonitrile, hydrophilic polypropylene, hydrophilic polyvinyl alcohol, nano cellulose, glass fiber and the like.
Further, the monofilament fineness of the superfine fiber is 0.3 dtex-1.0 dtex.
Experiments show that the sampling time of the fiber bundle 201 provided by the embodiment is within 10s, and compared with the original sampling time of 3min, the sampling time is greatly shortened. In addition, the fiber bundle 201 provided in this embodiment can be inserted and pulled out, so that the sampling is convenient and the sampling amount is small.
Referring to fig. 2 and 4, in this embodiment, a first limiting boss 105 and a second limiting boss 108 are fixed in the shell slot 104, where the second limiting boss 108 is located at a side of the first limiting boss 105 away from the test paper 3, and the second limiting boss 108 is provided with a board passing notch 1081.
The outside of the sampler 2 is provided with a clamping plate 203 which can pass through the plate passing notch 1081 and enter a limiting gap between the first limiting boss 105 and the second limiting boss 108. When the fiber bundle 201 is inserted into the shell slot 104, the card 203 is aligned with the through-board notch 1081, such that the card 203 enters the spacing gap, and then the sampler is rotated 90 °, i.e., such that the card 203 is offset from the through-board notch 1081, such that the card is restrained in the spacing gap.
At this time, on the one hand, the first limiting boss 105 blocks the clamping plate 203 to limit the continuous insertion of the sampler 2, so as to avoid excessive extrusion of the fiber bundle 201; on the other hand, the second limiting boss 108 blocks the outward movement of the clamping plate 203, so that the fiber bundle 201 is continuously in a pressed state, which is beneficial for the sample to be detected to be separated from the fiber bundle 201, enter the shell slot 104, and enter the detection cavity 103 through the inclined channel 107. Wherein an inclined channel 107 which extends obliquely to communicate the detection cavity 103 with the shell slot 104 is arranged from the other end of the bottom of the shell slot 104; furthermore, the clamping plate 203 also plays a role of blocking flow to prevent the sample to be detected in the shell slot 104 from flowing out.
Referring to fig. 3, two drainage baffles 1022 are fixedly disposed at a side of the lower housing 102 close to the observation window 1011, and two drainage baffles 1022 and an inner wall of the lower housing 102 enclose a test paper slot 1021 with an opening facing the observation window 1011.
One end of the test paper 3 is located in the test paper slot 1021, and the other end passes through the inclined channel 107 and stretches into the shell slot 104, so that a drainage effect is achieved on a sample to be tested in the shell slot 104, the sample to be tested flows from the shell slot 104 to the detection cavity 103 along the test paper 3, namely, the plug-in type poison detection card 100 provided by the embodiment, the sample to be tested in the interior is not completely driven by gravity, and therefore a supervisor can smoothly realize poison suction detection by holding the shell 1 in various postures in a detection chamber.
Optionally, an included angle between the inclined channel 107 and the length direction of the plug-in poison detection card 100 is between 10 ° and 90 °.
In this embodiment, after the clamping plate 203 is clamped into the limiting gap, a buffer space 109 is reserved between the fiber bundle 201 and the inclined passage 107.
It should be noted that, the buffer space 109 and the inclined channel 107 may be used as a buffer area before the sample to be detected enters the detection cavity 103, and play a role in buffering the sample to be detected in the shell slot 104, so as to avoid the problem that after the sampler 2 is extruded, a large amount of sample to be detected rapidly gushes into the detection cavity 103 to cause insufficient reaction (flushing) of the test paper 3.
It is worth pointing out that, setting up test paper groove 1021 can guide the sample to be detected in the detection chamber 103 to flow mainly in test paper groove 1021, has avoided the invalid diffusion of sample to be detected in detection chamber 103, and then improves the concentration degree of sample to be detected, and this can accelerate the reaction rate between sample to be detected and the test paper 3, further shortens the detection time.
Optionally, the width of the test paper 3 is 0.5 mm-2.5 mm, and the reaction time can be reduced by properly reducing the width of the test paper 3.
Of course, in some other embodiments, a plurality of supporting bosses spaced apart from each other may be disposed on the inner side of the lower case 102, and after the test strip 3 is placed on each supporting boss, the upper case 101 is fastened to clamp and fix the test strip 3.
The plug-in poison detection card 100 provided in this embodiment has the following advantages:
(1) the fiber bundle 201 with superfine fibers is adopted for sampling, so that enough samples to be detected can be acquired within 10 seconds, and the sampling time is greatly shortened;
(2) the test paper 3 is of a long and narrow structure, so that the required dosage of a sample to be detected is effectively reduced, the reaction is rapid, and the reaction can be completed within 30-40 seconds, so that a detection result is obtained;
(3) the detection test paper 3 is placed in the test paper groove 1021, so that the flow speed of a sample to be detected is increased through capillary action, and the reaction time is effectively shortened;
(4) the detection test paper 3 is elastically deformed in the inclined channel 107, namely, the detection test paper 3 forms a certain inclined included angle with the length direction of the plug-in type poison detection card 100, so that the contact area between the detection test paper 3 and a sample to be detected is enlarged, the contact amount between the sample to be detected and the detection test paper 3 is increased in unit time, and the reaction time of the detection test paper 3 is shortened;
(5) the distance between the end surface of the first limiting boss 105 abutting against the clamping plate 203 and the end surface of the extruding boss 106 extruding the fiber bundle 201 is smaller than the length of the fiber bundle 201 in a natural state, so that after the sampler 2 is inserted into the shell slot 104, the fiber bundle 201 is subjected to compression bending deformation, so that a sample to be detected contained in the sampler 2 is extruded, and the sample to be detected moves directionally under the action of pressure, and therefore, the test paper 3 does not need to be placed strictly and horizontally like the existing test paper in working; the test paper 3 can adapt to more application scenes;
(6) the clamping plate 203 is in interference fit with the shell slot 104, and after the sampler 2 is inserted into the shell slot 104, the clamping plate 203 can be clamped in the shell slot 104 so as to prevent the sampler 2 from being separated from the shell 1 in the detection process;
(7) the inclined channel 107 can play a role in buffering, so that the sample to be detected is prevented from entering the detection cavity 103 quickly, and the accuracy of the detection result is improved;
(8) the portable terminal 200 is used for automatic judgment, so that the dependence on manpower is reduced, the accuracy of a detection result is improved, and the risk of misjudgment is reduced.
It should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is for clarity only, and that the skilled artisan should recognize that the embodiments may be combined as appropriate to form other embodiments that will be understood by those skilled in the art.
The above list of detailed descriptions is only specific to practical embodiments of the present invention, and they are not intended to limit the scope of the present invention, and all equivalent embodiments or modifications that do not depart from the spirit of the present invention should be included in the scope of the present invention.

Claims (7)

1. A one minute rapid poison detection apparatus comprising:
the plug-in type poison detection card comprises a sampler for acquiring a sample to be detected, a shell connected with the sampler in a plug-in manner and detection test paper positioned in the shell; the detection test paper is used for reacting with the sample to be detected;
the portable terminal is detachably connected with the pluggable poison detection card and is used for acquiring the visual change condition of the detection test paper and generating a detection result according to the visual change condition;
the shell is provided with an observation window for observing the visual effect change of the detection test paper; the shell comprises an upper shell and a lower shell, two drainage baffles are fixedly arranged at intervals on one side of the lower shell, close to the observation window, and the two drainage baffles and the inner wall of the lower shell enclose a test paper groove with an opening facing the observation window;
a detection cavity for storing the detection test paper is formed in the shell, and a shell slot communicated with the detection cavity is formed in the end face of one end of the shell;
the sampler comprises a fiber bundle connected with the shell slot in a plugging manner and a handheld part fixed at one end of the fiber bundle far away from the shell; the other end of the fiber bundle is used for obtaining the sample to be detected;
the fiber bundles are made of superfine natural fibers and/or superfine artificial synthetic fibers; the monofilament fineness of the superfine fiber is 0.3 dtex-1.0 dtex;
a first limit boss is fixedly arranged in the shell slot, and a clamping plate is arranged outside the sampler;
when the sampler is inserted into the shell slot, the first limiting boss abuts against the clamping plate so as to limit the continued insertion of the sampler;
a second limiting boss is arranged on one side, away from the detection test paper, of the first limiting boss; the second limiting boss is provided with a plate passing notch;
the outside of sampler is equipped with can pass the board breach gets into cardboard in the spacing clearance between first spacing boss and the spacing boss of second.
2. The one-minute rapid poison detection device of claim 1, wherein an end slot is provided on a surface of the portable terminal, and the plug-in poison detection card is plug-in connected with the end slot.
3. A one minute rapid toxicity test apparatus according to claim 2, wherein,
and an information acquisition unit for acquiring the visual effect change is arranged at the position corresponding to the observation window in the end slot.
4. The one-minute rapid toxicity test apparatus of claim 3, wherein said portable terminal further comprises:
the data processing unit is connected with the information acquisition unit and is used for processing the data acquired by the information acquisition unit and generating the detection result;
and the terminal output device is electrically connected with the data processing unit and is used for providing display of at least one of information of pictures, characters, videos, sounds or lights for the supervisory personnel according to the detection result.
5. The rapid one-minute poison detection apparatus of claim 3 or 4, wherein said information acquisition unit is a fluorescence sensor or an image sensor.
6. The one-minute rapid toxicity test apparatus of claim 1, wherein the slot bottom of the housing slot is provided with an inclined channel extending obliquely to communicate the test cavity with the housing slot;
one end of the test paper penetrates through the inclined channel and stretches into the shell slot.
7. The one-minute rapid toxicity test apparatus of claim 1 or 6, wherein the slot bottom of the housing slot is further provided with a pressing boss for pressing the fiber bundle.
CN202111178163.5A 2021-10-09 2021-10-09 One minute quick poison detection device Active CN113866401B (en)

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PCT/CN2022/119591 WO2023056837A1 (en) 2021-10-09 2022-09-19 Rapid drug test method, one-minute rapid drug test device, and distributed drug test system

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