CN113865276A - Keratinocyte growth factor drying device - Google Patents
Keratinocyte growth factor drying device Download PDFInfo
- Publication number
- CN113865276A CN113865276A CN202111171018.4A CN202111171018A CN113865276A CN 113865276 A CN113865276 A CN 113865276A CN 202111171018 A CN202111171018 A CN 202111171018A CN 113865276 A CN113865276 A CN 113865276A
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- CN
- China
- Prior art keywords
- growth factor
- keratinocyte growth
- drying device
- drying box
- drying
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/06—Chambers, containers, or receptacles
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
- F26B9/06—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers
Abstract
The invention relates to a drying device, in particular to a keratinocyte growth factor drying device. The utility model provides a keratinocyte growth factor drying device, includes dry box, riser and buckle closure, the right side and the upside of dry box are open, and the upside of dry box is provided with the buckle closure, and the riser is sliding connection in the dry box in left and right directions. The utility model provides a keratinocyte growth factor drying device still includes violently pipe and solenoid valve, and the left part fixed connection of violently pipe is in the right side center of riser, and the right part of violently pipe is provided with the solenoid valve. The keratinocyte growth factor drying device further comprises a refrigerator, and the refrigerator is arranged on the left side of the drying box. The utility model provides a keratinocyte growth factor drying device still includes V-arrangement arris and triangular plate, and both sides all are provided with the triangular plate around the buckle closure, and both sides all are provided with the V-arrangement arris around the drying box, and two triangular plates are inserted respectively on two V-arrangement arriss. The invention can freeze-dry the purified protein liquid to finish the production of the keratinocyte growth factor.
Description
Technical Field
The invention relates to a drying device, in particular to a keratinocyte growth factor drying device.
Background
The keratinocyte growth factor is a basic protein growth factor secreted by human subcutaneous histiocytes, and can specifically stimulate the physiological processes of metabolism and the like of epithelial cells, including regeneration, differentiation, migration and the like of the cells. Keratinocyte factor, also known as FGF-10, is a member of the large family of fibroblast growth factors that is later successfully cloned and is an outcome of the human genome project. The technical route for producing and preparing the keratinocyte growth factor is as follows: 1. cloning rhKGF-2 expression vector of target gene, and transforming, screening and identifying high-efficiency soluble expression engineering bacteria; 2. culturing engineering bacteria in a large scale; 3. purifying the fermentation product to obtain rhKGF-2 protein liquid; 4. adding stabilizer and excipient, and freeze drying. In order to freeze-dry the purified protein solution and finally complete the production of the keratinocyte growth factor, a keratinocyte growth factor drying device is designed.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides the keratinocyte growth factor drying device, which has the beneficial effect that the protein liquid obtained by purification can be subjected to freeze drying to complete the production of the keratinocyte growth factor.
The utility model provides a keratinocyte growth factor drying device, includes dry box, riser and buckle closure, the right side and the upside of dry box are open, and the upside of dry box is provided with the buckle closure, and the riser is sliding connection in the dry box in left and right directions.
The utility model provides a keratinocyte growth factor drying device still includes violently pipe and solenoid valve, and the left part fixed connection of violently pipe is in the right side center of riser, and the right part of violently pipe is provided with the solenoid valve.
The keratinocyte growth factor drying device further comprises a refrigerator, and the refrigerator is arranged on the left side of the drying box.
The utility model provides a keratinocyte growth factor drying device still includes V-arrangement arris and triangular plate, and both sides all are provided with the triangular plate around the buckle closure, and both sides all are provided with the V-arrangement arris around the drying box, and two triangular plates are inserted respectively on two V-arrangement arriss.
The utility model provides a keratinocyte growth factor drying device still includes the support, and the left part fixed connection of support is in the left side of drying box.
Drawings
The invention is described in further detail below with reference to the accompanying drawings and specific embodiments.
FIG. 1 is a schematic diagram of a keratinocyte growth factor drying device;
FIG. 2 is a schematic structural diagram II of a keratinocyte growth factor drying device;
FIG. 3 is a first schematic structural diagram of a drying box;
FIG. 4 is a second schematic structural view of the drying box;
FIG. 5 is a schematic structural view of a tray;
FIG. 6 is a first schematic structural view of the buckle cover;
FIG. 7 is a second schematic structural view of the buckle cover;
FIG. 8 is a first structural view of a door frame;
FIG. 9 is a second schematic structural view of the door frame;
FIG. 10 is a schematic diagram of a set-top box;
FIG. 11 is a first schematic view of a lapping cloth structure;
FIG. 12 is a second schematic view of the structure of the lapping cloth.
In the figure: a drying box 101; a V-shaped ridge 102; a telescopic rod I103; a cross-frame 104; a fixed base 105; a shifting fork I106; a refrigerator 107; a bracket 108;
a tray 301; a lifting bar 302;
a buckle cover 401; an empty slot 402; a triangular plate 403;
a gantry 501; a runner 502; a stopper 503; a hand screw 504; a rubber strip 505; a roller 506; a lifting beam 507;
a set-top box 601; a shifting fork II 602; a strut 603; a telescopic rod II 604;
Detailed Description
Referring to fig. 3-7, for example, there is shown an embodiment of the present invention that addresses the problem of facilitating sublimation of water in a protein fluid of keratinocyte growth factor,
because keratinocyte growth factor drying device includes dry box 101, riser 203 and buckle closure 401, the upside and the right side of dry box 101 are open, buckle closure 401 sets up the upside at dry box 101, riser 203 sliding connection is in dry box 101, place the refrigerated albumen liquid that has keratinocyte growth factor inside dry box 101, then buckle closure 401 moves right and makes the inside volume increase of dry box 101, and then reduce the inside atmospheric pressure of dry box 101, and then be convenient for have the moisture sublimation in keratinocyte growth factor's the albumen liquid, accomplish the freeze-drying of albumen liquid, accomplish the production of keratinocyte growth factor.
Referring to fig. 3-7, for example, there is shown an embodiment of the present invention that solves the problem of evacuating the interior of drying box 101 through cross tube 201,
because keratinocyte growth factor drying device still includes violently pipe 201 and solenoid valve 205, violently pipe 201 fixed connection is in the right side center of riser 203, and solenoid valve 205 sets up the right part at violently pipe 201, can evacuate the inside of dry box 101 through violently pipe 201 after opening solenoid valve 205, and then further make the moisture sublimation in the albumen liquid.
Referring to fig. 3, for example, an embodiment of the present invention is shown that addresses the problem of facilitating direct sublimation of moisture in a protein liquid,
because the keratinocyte growth factor drying device further comprises a refrigerator 107, the refrigerator 107 is arranged on the left side of the drying box 101, the refrigerator 107 can freeze protein liquid with keratinocyte growth factors placed inside the drying box 101, and then the drying box 101 is changed into a vacuum state, so that water in the protein liquid can be sublimated directly.
Referring to fig. 3-7, for example, an embodiment of the present invention is shown that addresses the problem of improving the stability of the buckle closure 401,
because keratinocyte growth factor drying device still includes V-arrangement arris 102 and triangular plate 403, two triangular plates 403 set up respectively in buckle closure 401's front and back both sides, two V-arrangement arris 102 set up respectively in the front and back both sides of drying box 101, two triangular plates 403 insert respectively on two V-arrangement arris 102, and then can prevent buckle closure 401 from removing at will through the cooperation of V-arrangement arris 102 and triangular plate 403, improve buckle closure 401's stability.
Referring to fig. 3-4, for example, an embodiment of the present invention is shown that solves the problem of the bracket 108 serving to support the drying box 101,
since the keratinocyte growth factor drying device further comprises a bracket 108, the bracket 108 is fixedly connected to the left side of the drying box 101, and the bracket 108 plays a role of supporting the drying box 101.
Referring to fig. 1-9, for example, there is shown an embodiment of the present invention that solves the problem of pressing the front and rear edges of the cover 401 to improve the sealing effect between the cover 401 and the drying box 101,
because keratinocyte growth factor drying device still includes portal frame 501, runner 502, hand screw 504, gyro wheel 506 and lifting beam 507, two runners 502 rotate respectively and connect the front and back both ends in portal frame 501 upper portion, lifting beam 507 vertical sliding connection is in the lower part of portal frame 501, the upside of lifting beam 507 rotates and is connected with two gyro wheels 506, hand screw 504 passes through threaded connection in the lower part of portal frame 501, hand screw 504 sets up the downside at lifting beam 507, make two runners 502 press respectively at the front and back edge of buckle closure 401, two gyro wheels 506 voltage-sharing are at the downside of drying box 101, then move portal frame 501 about, make two runners 502 constantly move about the front and back edge of buckle closure 401, and then press the front and back edge of buckle closure 401, improve the sealed effect between buckle closure 401 and drying box 101. The hand screw 504 is rotated to press the hand screw 504 to the lifting beam 507, so that the two rollers 506 are pressed on the lower side of the drying box 101, the two rotating wheels 502 are respectively pressed on the front and rear edges of the buckle cover 401, and the pressure of the two rotating wheels 502 on the front and rear edges of the buckle cover 401 can be adjusted through the hand screw 504.
Referring to fig. 1-9, for example, there is shown an embodiment of the present invention that solves the problem of avoiding excessive force of two rollers 502 pressing against the front and rear edges of the buckle cover 401,
because keratinocyte growth factor drying device still includes rubber strip 505, rubber strip 505 sets up in the downside middle part of lifting beam 507, the upper end of hand screw 504 is pressed on rubber strip 505, and then set up rubber strip 505 between hand screw 504 and lifting beam 507, hand screw 504 presses and can press on rubber strip 505 earlier before on lifting beam 507, it is too big to avoid two gyro wheels 506 on lifting beam 507 to press the power of drying box 101 downside, and then avoid two runners 502 to press the power too big at the front and back edge of buckle closure 401 respectively.
Referring to fig. 8-9, for example, embodiments of the present invention are shown that address the problem of preventing excessive upward movement of the lifting beam 507 relative to the gantry 501,
because keratinocyte growth factor drying device still includes dog 503, and two dogs 503 set up the front and back both sides in portal 501 lower part respectively, and the lifting beam 507 is located the downside of two dogs 503, and two dogs 503 have played the limiting displacement to lifting beam 507, prevent that lifting beam 507 from moving too big relatively portal 501 upwards.
Referring to fig. 1-9, for example, there is shown an embodiment of the present invention that addresses the problem of accelerating lyophilization of a protein fluid,
because keratinocyte growth factor drying device still includes tray 301 and shadoof 302, a plurality of trays 301 set up on shadoof 302 from last to down, and a plurality of trays 301 all place the left part at dry box 101, all can put into the albumen liquid that has keratinocyte growth factor on a plurality of trays 301, and then divide into the multilayer with the albumen liquid and place for the freeze-drying of albumen liquid.
Referring to fig. 3, for example, an embodiment of the present invention is shown to solve the problem of the cross plate 202 further improving the sealing effect of the sliding connection position of the vertical plate 203 and the drying box 101,
since the keratinocyte growth factor drying device further comprises a horizontal plate 202, the horizontal plate 202 is arranged at the upper part of the right side of the vertical plate 203, the upper side of the horizontal plate 202 is flush with the upper side of the drying box 101, and the horizontal plate 202 further improves the sealing effect of the sliding connection position of the vertical plate 203 and the drying box 101.
Keratinocyte growth factor drying device still includes telescopic link I103, sideslip frame 104, fixing base 105, shift fork I106 and ring channel 204, the right-hand member of violently managing 201 is provided with ring channel 204, the front side right-hand member of dry box 101 is provided with fixing base 105, lateral sliding connection has sideslip frame 104 on the fixing base 105, fixedly connected with telescopic link I103 on the fixing base 105, the expansion end fixed connection of telescopic link I103 is at the tip of sideslip frame 104, the right-hand member of sideslip frame 104 is provided with shift fork I106, shift fork I106 is inserted on ring channel 204.
Referring to fig. 3-4, for example, an embodiment of the present invention is shown to address the problem of moving the risers 203 of the cross boards 202 to the left and right,
when the telescopic rod I103 stretches, the transverse moving frame 104 can be driven to slide on the fixing seat 105, the shifting fork I106 is driven to move left and right, when the shifting fork I106 is inserted into the annular groove 204, the shifting fork I106 can drive the transverse pipe 201 to move left and right, the transverse plate 202 and the vertical plate 203 are driven to move left and right, and the atmospheric pressure inside the drying box 101 is changed.
The keratinocyte growth factor drying device further comprises a hollow groove 402, a top box 601 and activated carbon bags 702, the hollow groove 402 is formed in the buckle cover 401, the top box 601 is fixed to the hollow groove 402 on the buckle cover 401, and the plurality of activated carbon bags 702 are arranged in the top box 601.
Referring to fig. 1-12, for example, embodiments of the present invention are shown that address the problem of water vapor being absorbed by an activated carbon packet 702 after sublimation,
the empty groove 402 enables the top box 601 and the drying box 101 to be communicated with each other, a plurality of activated carbon bags 702 in the top box 601 can absorb water vapor, and then the water vapor can be absorbed by the activated carbon bags 702 after being sublimated, so that the freeze drying effect of the protein liquid is improved.
The keratinocyte growth factor drying device further comprises a piece of cloth 701, side beams 703, hooks 704, round rods 705 and clamping rods 706, the round rods 705 are fixedly connected between the front ends of the two side beams 703 and between the rear ends of the two side beams 703, the two side beams 703 are respectively connected to the left side and the right side inside the top box 601 through screws, a plurality of hooks 704 are hung on each round rod 705, the hooks 704 on the two round rods 705 correspond to each other one by one in the front and back direction, the two clamping rods 706 are arranged between the two corresponding hooks 704, the piece of cloth 701 penetrates through gaps between the two clamping rods 706 to be placed to form waves, and a plurality of activated carbon bags 702 are arranged on the piece of cloth 701.
Referring to fig. 1-12, for example, embodiments of the present invention are shown that address the problem of having multiple activated carbon packets 702 constantly and efficiently absorb sublimed water vapor,
two round bars 705 can supply a plurality of couples 704 to slide from side to side above that, and then drive a plurality of clamping bars 706 and remove about, can be with taking cloth 701 to contract when being close to between a plurality of clamping bars 706, and then will take a plurality of activated carbon package 702 on cloth 701 to receive together, can will take cloth 701 to expand when a plurality of clamping bars 706 are kept away from, and then will take a plurality of activated carbon package 702 on cloth 701 to diffuse, constantly make a plurality of activated carbon package 702 receive together and diffuse, constantly circulate, make a plurality of activated carbon package 702 constantly absorb sublimed vapor effectively, and then carry out freeze-drying with the albumen liquid, accomplish keratinocyte growth factor's production.
The keratinocyte growth factor drying device further comprises a shifting fork II602, sliding columns 603 and telescopic rods II604, the two sliding columns 603 are respectively connected to the left side and the right side of the top box 601 in a transverse sliding mode, the shifting fork II602 is arranged at the inner ends of the two sliding columns 603, the two shifting forks II602 are respectively inserted into the two clamping rods 706 at the left end and the right end of the top box 601, the telescopic rods II604 are fixedly connected to the left side and the right side of the top box 601, and the movable ends of the two telescopic rods II604 are respectively and fixedly connected to the outer ends of the two sliding columns 603.
Referring to fig. 1-12, for example, embodiments of the present invention are shown that address the problem of constantly bringing together and spreading a plurality of activated carbon packets 702,
when the telescopic rod II604 stretches, the sliding column 603 and the shifting fork II602 can be driven to move left and right, the shifting fork II602 moves left and right to drive the two clamping rods 706 at the left end and the right end to move left and right, and further to control the plurality of clamping rods 706 to be close to each other or the plurality of clamping rods 706 to be far away from each other, so that the plurality of activated carbon bags 702 are continuously collected and diffused.
Claims (10)
1. A keratinocyte growth factor drying device comprises a drying box (101), a vertical plate (203) and a buckle cover (401), and is characterized in that: the right side and the upside of drying box (101) are open, and the upside of drying box (101) is provided with buckle closure (401), and riser (203) sliding connection is in drying box (101) in the left and right directions.
2. The keratinocyte growth factor drying device according to claim 1, wherein: still include violently pipe (201) and solenoid valve (205), the left part fixed connection of violently pipe (201) is in the right side center of riser (203), and the right part of violently pipe (201) is provided with solenoid valve (205).
3. The keratinocyte growth factor drying device according to claim 2, wherein: the drying box further comprises a refrigerator (107), and the refrigerator (107) is arranged on the left side of the drying box (101).
4. The keratinocyte growth factor drying device according to claim 1, wherein: the drying box is characterized by further comprising V-shaped ribs (102) and triangular plates (403), the triangular plates (403) are arranged on the front side and the rear side of the buckle cover (401), the V-shaped ribs (102) are arranged on the front side and the rear side of the drying box (101), and the two triangular plates (403) are inserted into the two V-shaped ribs (102) respectively.
5. The keratinocyte growth factor drying device according to claim 1, wherein: the drying box further comprises a support (108), and the left part of the support (108) is fixedly connected to the left side of the drying box (101).
6. The keratinocyte growth factor drying device according to claim 3, wherein: still include door shape frame (501), runner (502), hand screw (504), gyro wheel (506) and lifting beam (507), both ends all rotate around door shape frame (501) upper portion and are connected with runner (502), lifting beam (507) is sliding connection in the lower part of door shape frame (501) on the upper and lower direction, both ends all rotate and are connected with one gyro wheel (506) about lifting beam (507) upside, the lower part threaded connection of door shape frame (501) has hand screw (504), hand screw (504) are located the downside of lifting beam (507), two runner (502) are pressed respectively at the front and back edge of buckle closure (401), two gyro wheel (506) voltage-sharing are at the downside of dry box (101).
7. The keratinocyte growth factor drying device according to claim 6, wherein: the lifting beam is characterized by further comprising a rubber strip (505), the middle of the lower side of the lifting beam (507) is provided with the rubber strip (505), and the upper end of the hand-screwed screw (504) is pressed on the rubber strip (505).
8. The keratinocyte growth factor drying device according to claim 7, wherein: the lifting beam is characterized by further comprising stop blocks (503), the front side and the rear side of the lower portion of the door-shaped frame (501) are respectively provided with the stop blocks (503), and the two stop blocks (503) are located on the upper side of the lifting beam (507).
9. The keratinocyte growth factor drying device according to claim 1, wherein: still include tray (301) and lifting lever (302), lifting lever (302) are gone up and are provided with a plurality of trays (301) from last to bottom, and a plurality of trays (301) are all placed in the left part of drying box (101).
10. The keratinocyte growth factor drying device according to claim 8, wherein: the drying box further comprises a transverse plate (202), the left part of the transverse plate (202) is fixed on the upper part of the right side of the vertical plate (203), and the upper side of the transverse plate (202) is flush with the upper side of the drying box (101).
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| CN202111171018.4A CN113865276B (en) | 2021-10-08 | 2021-10-08 | Keratinocyte growth factor drying device |
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| CN202111171018.4A CN113865276B (en) | 2021-10-08 | 2021-10-08 | Keratinocyte growth factor drying device |
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| CN113865276B CN113865276B (en) | 2022-10-21 |
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