CN113856014A - Accurate control system that doses - Google Patents
Accurate control system that doses Download PDFInfo
- Publication number
- CN113856014A CN113856014A CN202111289039.6A CN202111289039A CN113856014A CN 113856014 A CN113856014 A CN 113856014A CN 202111289039 A CN202111289039 A CN 202111289039A CN 113856014 A CN113856014 A CN 113856014A
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- CN
- China
- Prior art keywords
- medicine
- drug delivery
- micropump
- control system
- integrated circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0662—Ears
Abstract
The invention discloses an accurate drug delivery control system, relates to a drug delivery device, and solves the problems that the traditional cochlear drug delivery device has high drug consumption, low use efficiency, incapability of realizing accurate drug delivery and the like; the IC integrated circuit is respectively connected with the MEMS micropump and the energy storage device, and an inlet of the MEMS micropump is connected with an outlet of the drug storage pool; the medicine storage pool is also provided with an inlet and a ventilation port; the voltage of the energy storage device is amplified by the IC integrated circuit and then acts on the MEMS micropump to drive the micropump to input liquid medicine. The invention can accurately control the flow rate of the liquid medicine in a liquid drop mode according to the required administration frequency, so that the liquid medicine continuously acts on a cochlea in a liquid drop mode, the concentration of the medicine is ensured to be maintained in a proper range, meanwhile, the loss of the medicine flowing out through a eustachian tube can be reduced, the utilization rate of the medicine is increased, the action effect of the medicine is enhanced, and the effective action time of the medicine is prolonged.
Description
Technical Field
The invention relates to a drug delivery device, in particular to an accurate drug delivery control system.
Background
China is the country with the most hearing disabilities worldwide, and the medical treatment demand is huge. The treatment of hearing loss is critical to the precise administration of drugs to the inner ear, especially the cochlea. In addition to the fact that the traditional drug delivery device is difficult to act on the inner ear through blood circulation, the traditional drug delivery device has the limitations of high drug bottle consumption, low efficiency, large toxic and side effects, high trauma, susceptibility to infection and the like, and the microchip has the advantages of integration, high precision, low toxic and side effects and the like.
The currently reported cochlear administration devices all have certain drawbacks. For example, the traditional drug delivery device has the defects of large drug consumption, low efficiency, large toxic and side effect, high wound, susceptibility to infection and the like. The prior art discloses a cochlea hose ware of dosing, its medicine outlet is hollow out construction, and the application mechanical principle will be stored in the liquid medicine of giving the medicine inslot and pass through the push rod and spout the cochlea affected part, and this kind of dosing device simple structure, unable accurate control liquid medicine flow, uncontrollable with the contact time of round window membrane, and because the injection causes the medicament extravagant, the liquid medicine mostly can be followed eustachian tube and run off, only has trace liquid medicine to save in round window membrane affected part. In addition, such devices do not allow for continuous administration of the drug. The earplug type tympanometry drug delivery device invented by Liwangwei and the like of Nanjing Chinese medicine university conveys the liquid medicine to the cochlea by puncturing the tympanic membrane, and has the defects of liquid medicine waste and incapability of quantitatively and accurately controlling the flow of the liquid medicine. Although the micro automatic controlled release drug can reduce toxic and side effects, the release of the drug is limited by physiological factors, and the control precision is about 1 mg/h. In order to realize local accurate drug delivery of the cochlea, the invention provides a novel drug delivery system.
Disclosure of Invention
The invention provides an accurate drug delivery control system for solving the problems that the traditional cochlear drug delivery device has high drug consumption, low use efficiency, incapability of realizing quantitative and accurate control of drug delivery and the like.
The accurate drug delivery control system comprises an IC integrated circuit, an MEMS micropump, a drug storage pool and an energy storage device which are integrated on an outer shell;
the IC integrated circuit is respectively connected with the MEMS micropump and the energy storage device, and an inlet of the MEMS micropump is connected with an outlet of the medicine storage pool;
the medicine storage pool is also provided with an inlet and a ventilation port;
the voltage of the energy storage device is amplified by the IC integrated circuit and then acts on the MEMS micropump to drive the micropump to input liquid medicine.
Further, the IC integrated circuit and the medicine storage pool are respectively positioned at the upper part and the lower part of the outer shell; the material of medicine storage tank is the PE material, and the vent of medicine storage tank adopts the ventilative design of pellicle, the pellicle material is medical grade ePTFE material.
Further, the MEMS micropump is square.
Furthermore, the energy storage device is a lithium battery, and the lithium battery is placed in the MEMS micropump.
The invention has the beneficial effects that: the accurate drug delivery control system provided by the invention can accurately control the flow of the liquid medicine in a liquid drop mode by accurately controlling the flow according to the required drug delivery frequency, so that the liquid medicine continuously acts on a cochlea in a liquid drop mode, the concentration of the drug is ensured to be maintained in a proper range, meanwhile, the loss of the drug flowing out through a eustachian tube can be reduced, the utilization rate of the drug is increased, the action effect of the drug is enhanced, and the effective action time of the drug is prolonged. And the invention can be extended to intramuscular injection type drug delivery systems.
1. The whole layout is novel, the size is small, the space utilization rate is high, the wearable type cochlear implant can be worn, and besides being applied to cochlear treatment, the cochlear implant can also be applied to intramuscular injection, and the application range is wide;
2. the accurate flow control of the micropump can achieve the micro drug delivery flow required in the treatment of the inner ear, and can accurately control the flow according to the requirement, and the flow control is simple and convenient; the invention can adopt micro-droplets and a tissue infiltration mode, can achieve the fine flow of 0.44mg/h and is not influenced by physiological factors.
3. The invention has higher practical value and can realize quantitative administration for a plurality of times by implantation once;
4. the manufacturing cost is low, and mass production can be realized.
Drawings
FIG. 1 is an assembly view of a precision drug delivery control system according to the present invention;
FIG. 2 is a schematic diagram of the overall packaging of the precise drug delivery control system according to the present invention;
fig. 3 is a graph showing the flow effect of the micro-pump under different voltages and frequencies in two operation modes (i.e. droplet mode and tissue penetrating mode).
In the figure, 1, a shell, 2, a MEMS micropump, 3, an IC integrated circuit, 4, a battery, 5 and a medicine storage pool.
Detailed Description
Referring to fig. 1 to 3, the precise drug delivery control system of the present embodiment includes a drug reservoir 5, a MEMS micro pump 2, a battery 4 (energy storage device), an IC integrated circuit 3, and a housing 1, and the assembly diagram is shown in fig. 1. The IC integrated circuit 3 is positioned on the upper part of the shell 1, one end of the IC integrated circuit is connected with the MEMS micropump 2 through a lead, the other end of the IC integrated circuit is connected with the battery 4 through a lead, the battery 4 is placed on the MEMS micropump 2, the inlet of the MEMS micropump 2 is connected with the medicine storage pool 5, and the medicine storage pool 5 is positioned at the lowest end of the shell 1.
In this embodiment, the liquid medicine is stored in the medicine storage tank, and the medicine storage tank design is similar in order to increase space utilization with casing the latter half shape, and the material in medicine storage tank adopts the nontoxic biocompatible PE material to the human body, and total volume is about 1ml, and its scavenge port adopts the ventilative design of pellicle, and the membrane material is medical grade expanded polytetrafluoroethylene (ePTFE). The medicine storage pool has three interfaces, one of which is used as a medicine liquid inlet, the other interface is used as a ventilation port, and the outlet is used for being connected with the micro pump. When the device is used for inner ear treatment, the outlet of a micro pump in the device is required to be connected with a drug delivery channel and the outlet of the channel is arranged above a round window membrane, and the generation rate of liquid drops is controlled by controlling the flow of the micro pump through an IC circuit so as to achieve the precision required by cochlear drug delivery, namely a liquid drop type working mode; when the device is used for intramuscular tissue injection, the outlet of the drug administration channel is required to be connected with the micro needle, the micro needle is used for direct injection, and the liquid medicine enters a human body through tissue permeation, namely a tissue permeation type working mode at the moment.
In this embodiment, the MEMS micro pump 2 is square, has a model of Bartels MP5, has a size of 14 × 3.5mm, is limited in the housing 1 to reduce the shaking and avoid damage, and the outlet of the MEMS micro pump 2 is connected to the outlet of the drug reservoir. The voltage of the lithium battery is amplified by the IC and then acts on the MEMS micropump to drive the MEMS micropump to transport liquid medicine, the working principle is that the voltage drives the diaphragm of the MEMS micropump 2 to vibrate up and down, and different voltages and frequencies correspond to different amplitudes and response frequencies of diaphragm vibration. The battery 4, the IC integrated circuit 3 and the MEMS micropump are connected by a lead.
As shown in fig. 2, fig. 2 is an overall structure of the control system of the present embodiment, and has a size of 4 × 5 × 1cm, which is similar to the shape of a hearing aid.
As shown in fig. 3 (a), in the droplet mode operation, the flow rate of the control system according to the present embodiment increases as the operating voltage increases. The minimum energy can reach 0.44ml/h fine flow rate (voltage 3v), the maximum flow rate can reach 36.16ml/h (voltage 25v), when the liquid medicine is transported in solid tissues, the flow rate is 0.77ml/h when the voltage is 10v due to certain resistance of physiological tissues, and the flow rate is 6.5ml/h when the voltage is 25v, which is only 0.18 times of that when the liquid medicine is unloaded. As shown in fig. 3 (b), the minimum fine flow rate of 1.1ml/h is achieved at a frequency of 5Hz, the maximum flow rate of 8.82ml/h is achieved at a frequency of 50Hz, and the flow rate increases and then decreases with the frequency response, and reaches a peak at 50 Hz.
In the tissue penetration mode of operation, the working flow rate was 0.84ml/h at a frequency of 10Hz and 3.55ml/h at a frequency of 50Hz, which is only 0.4 times that in the droplet mode.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (5)
1. Accurate control system that doses, characterized by: the control system comprises an IC integrated circuit, an MEMS micropump, a drug storage pool and an energy storage device which are integrated on a shell;
the IC integrated circuit is respectively connected with the MEMS micropump and the energy storage device, and an inlet of the MEMS micropump is connected with an outlet of the medicine storage pool;
the medicine storage pool is also provided with an inlet and a ventilation port;
the voltage of the energy storage device is amplified by the IC integrated circuit and then acts on the MEMS micropump to drive the micropump to input liquid medicine.
2. The precision drug delivery control system of claim 1, wherein: the IC integrated circuit and the medicine storage pool are respectively positioned at the upper part and the lower part of the outer shell.
3. The precision drug delivery control system of claim 1, wherein: the material of medicine storage tank is the PE material, and the vent of medicine storage tank adopts the ventilative design of pellicle, the pellicle material is medical grade ePTFE material.
4. The precision drug delivery control system of claim 1, wherein: the MEMS micropump is square.
5. The precision drug delivery control system of claim 1, wherein: the energy storage device is a lithium battery, and the lithium battery is placed on the MEMS micropump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111289039.6A CN113856014A (en) | 2021-11-02 | 2021-11-02 | Accurate control system that doses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111289039.6A CN113856014A (en) | 2021-11-02 | 2021-11-02 | Accurate control system that doses |
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| Publication Number | Publication Date |
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| CN113856014A true CN113856014A (en) | 2021-12-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111289039.6A Pending CN113856014A (en) | 2021-11-02 | 2021-11-02 | Accurate control system that doses |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115430026A (en) * | 2022-09-23 | 2022-12-06 | 南京鼓楼医院 | Integrated artificial cochlea implant repeated delivery dosing electrode and control device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130053823A1 (en) * | 2011-02-02 | 2013-02-28 | Jason O. Fiering | Drug Delivery Apparatus |
-
2021
- 2021-11-02 CN CN202111289039.6A patent/CN113856014A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130053823A1 (en) * | 2011-02-02 | 2013-02-28 | Jason O. Fiering | Drug Delivery Apparatus |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115430026A (en) * | 2022-09-23 | 2022-12-06 | 南京鼓楼医院 | Integrated artificial cochlea implant repeated delivery dosing electrode and control device |
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