CN113853386A - 抗可变muc1*抗体及其用途 - Google Patents

抗可变muc1*抗体及其用途 Download PDF

Info

Publication number
CN113853386A
CN113853386A CN202080020073.0A CN202080020073A CN113853386A CN 113853386 A CN113853386 A CN 113853386A CN 202080020073 A CN202080020073 A CN 202080020073A CN 113853386 A CN113853386 A CN 113853386A
Authority
CN
China
Prior art keywords
antibody
consensus sequence
seq
fragment
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080020073.0A
Other languages
English (en)
Chinese (zh)
Inventor
C·巴姆达德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minerva Biotechnologies Corp
Original Assignee
Minerva Biotechnologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/019566 external-priority patent/WO2019165421A1/en
Priority claimed from PCT/US2019/021556 external-priority patent/WO2019173815A2/en
Application filed by Minerva Biotechnologies Corp filed Critical Minerva Biotechnologies Corp
Priority to CN202510558379.6A priority Critical patent/CN120484122A/zh
Publication of CN113853386A publication Critical patent/CN113853386A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4256—Tumor associated carbohydrates
    • A61K40/4257—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080020073.0A 2019-01-11 2020-01-13 抗可变muc1*抗体及其用途 Pending CN113853386A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510558379.6A CN120484122A (zh) 2019-01-11 2020-01-13 抗可变muc1*抗体及其用途

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962791661P 2019-01-11 2019-01-11
US62/791,661 2019-01-11
USPCT/US2019/019566 2019-02-26
PCT/US2019/019566 WO2019165421A1 (en) 2018-02-26 2019-02-26 Diagnostic methods using anti-muc1* antibodies
PCT/US2019/021556 WO2019173815A2 (en) 2018-03-09 2019-03-11 Method for anti-muc1* car t cell stimulation
USPCT/US2019/021556 2019-03-11
PCT/US2020/013410 WO2020146902A2 (en) 2019-01-11 2020-01-13 Anti-variable muc1* antibodies and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510558379.6A Division CN120484122A (zh) 2019-01-11 2020-01-13 抗可变muc1*抗体及其用途

Publications (1)

Publication Number Publication Date
CN113853386A true CN113853386A (zh) 2021-12-28

Family

ID=71521210

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080020073.0A Pending CN113853386A (zh) 2019-01-11 2020-01-13 抗可变muc1*抗体及其用途
CN202510558379.6A Pending CN120484122A (zh) 2019-01-11 2020-01-13 抗可变muc1*抗体及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202510558379.6A Pending CN120484122A (zh) 2019-01-11 2020-01-13 抗可变muc1*抗体及其用途

Country Status (8)

Country Link
US (1) US20220184120A1 (enExample)
EP (1) EP3908603A4 (enExample)
JP (2) JP2022527144A (enExample)
CN (2) CN113853386A (enExample)
AU (1) AU2020205735A1 (enExample)
CA (1) CA3126391A1 (enExample)
IL (1) IL284772A (enExample)
WO (1) WO2020146902A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114574446A (zh) * 2021-12-30 2022-06-03 深圳市先康达生命科学有限公司 一种目的基因可调控的工程化免疫细胞及其制备方法和应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016130726A1 (en) 2015-02-10 2016-08-18 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
WO2019165421A1 (en) * 2018-02-26 2019-08-29 Minerva Biotechnologies Corporation Diagnostic methods using anti-muc1* antibodies
EP4172215A4 (en) 2020-06-26 2024-11-20 Minerva Biotechnologies Corporation ANTI-NME ANTIBODIES AND METHOD OF TREATING CANCER OR CANCER METASTASES
CA3187555A1 (en) * 2020-07-29 2022-02-03 Minerva Biotechnologies Corporation Anti-variable muc1* antibodies and uses thereof
WO2022049217A1 (en) * 2020-09-04 2022-03-10 Miltenyi Biotec B.V. & Co. KG System for inducible expression of an adapter in immune cells
CA3237808A1 (en) * 2021-11-09 2023-05-19 Janssen Biotech, Inc. Microfluidic co-encapsulation device and system and methods for identifying t-cell receptor ligands
JP2025512466A (ja) * 2022-04-12 2025-04-17 ミネルバ バイオテクノロジーズ コーポレーション 抗可変ｍｕｃ１＊抗体およびその使用
IL316918A (en) * 2022-05-09 2025-01-01 Minerva Biotechnologies Corp Chimeric antigen receptor and IL-18 receptor compositions and methods of using them
US20240261406A1 (en) 2023-02-02 2024-08-08 Minerva Biotechnologies Corporation Chimeric antigen receptor compositions and methods for treating muc1* diseases
US20250121088A1 (en) * 2023-10-11 2025-04-17 Minerva Biotechnologies Corporation Anti-muc1* antibody drug complexes and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102239182A (zh) * 2008-10-06 2011-11-09 米纳瓦生物技术公司 Muc1*抗体
CN107660213A (zh) * 2015-02-10 2018-02-02 米纳瓦生物技术公司 人源化抗muc1*抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3087801A (en) * 2000-02-04 2001-08-14 Molecular Dynamics Inc Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
GB0802931D0 (en) * 2008-02-18 2008-03-26 Queen Mary & Westfield College Synthetic scFv analogue to the 6313/G2 (anti angiotensin II type 1 receptor) monoclonal anitbody variable regions
JP2012034668A (ja) * 2010-08-12 2012-02-23 Tohoku Univ ヒト型化抗ｅｇｆｒ抗体リジン置換可変領域断片及びその利用
CA2882222A1 (en) * 2012-08-14 2014-02-20 Minerva Biotechnologies Corporation Stem cell enhancing therapeutics
AR103867A1 (es) * 2015-03-06 2017-06-07 Sorrento Therapeutics Inc Anticuerpos contra inmunoglobulina y dominio 3 que contiene mucina de células t (anti-tim3), útiles como agentes terapéuticos
CA3039797A1 (en) * 2016-10-11 2018-04-19 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies and use of cleavage enzyme
WO2018132506A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation Chimeric antigen receptors based on alternative signal 1 domains
WO2019165421A1 (en) * 2018-02-26 2019-08-29 Minerva Biotechnologies Corporation Diagnostic methods using anti-muc1* antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102239182A (zh) * 2008-10-06 2011-11-09 米纳瓦生物技术公司 Muc1*抗体
US20170204191A1 (en) * 2008-10-06 2017-07-20 Cynthia C. Bamdad Muc1* antibodies
CN107660213A (zh) * 2015-02-10 2018-02-02 米纳瓦生物技术公司 人源化抗muc1*抗体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114574446A (zh) * 2021-12-30 2022-06-03 深圳市先康达生命科学有限公司 一种目的基因可调控的工程化免疫细胞及其制备方法和应用

Also Published As

Publication number Publication date
WO2020146902A3 (en) 2020-08-27
EP3908603A4 (en) 2023-01-11
CA3126391A1 (en) 2020-07-16
JP2025172739A (ja) 2025-11-26
JP2022527144A (ja) 2022-05-31
IL284772A (en) 2021-08-31
EP3908603A2 (en) 2021-11-17
US20220184120A1 (en) 2022-06-16
AU2020205735A1 (en) 2021-08-05
WO2020146902A2 (en) 2020-07-16
CN120484122A (zh) 2025-08-15

Similar Documents

Publication Publication Date Title
CN113853386A (zh) 抗可变muc1*抗体及其用途
JP7719855B2 (ja) 抗可変ｍｕｃ１＊抗体およびその使用
US11897967B2 (en) Humanized anti-MUC1* antibodies
AU2022275518B2 (en) Treatment of CD47+ disease cells with SIRP alpha-Fc fusions
US20240299507A1 (en) Humanized anti-muc1* antibodies and direct use of cleavage enzyme
US20220396616A1 (en) Novel cldn18.2 binding molecule
JP2023143904A (ja) ヒト化抗ｍｕｃ１＊抗体及び開裂酵素の使用
US20220144960A1 (en) Cd30-binding moieties, chimeric antigen receptors, and uses thereof
EA030182B1 (ru) Антитела, специфические для кадгерина-17
KR20180101483A (ko) 치료적 항-ｃｄ９ 항체
US20200405832A1 (en) Method for anti-muc1* car t cell stimulation
US20240390418A1 (en) Anti-variable muc1* antibodies and uses thereof
HK40064725A (en) Anti-variable muc1* antibodies and uses thereof
JP2015196665A (ja) 中和活性を有する抗ｌｒ１１モノクローナル抗体、及びそれを含有してなる医薬
TW202535920A (zh) 程序性死亡配體1（pd-l1）嵌合抗原受體及其應用
CA3229705A1 (en) Methods for detection of membrane bound glypican-3
Olsen Functional investigation of the EWS/ATF1 fusion protein: Implications for molecular therapy in clear cell sarcoma
JP2015199724A (ja) 中和活性を有する抗ｌｒ１１モノクローナル抗体、及びそれを含有してなる医薬

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40064725

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20211228

WD01 Invention patent application deemed withdrawn after publication