CN1138465A - Medicine for treatment of epilepsy - Google Patents
Medicine for treatment of epilepsy Download PDFInfo
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- CN1138465A CN1138465A CN95106942A CN95106942A CN1138465A CN 1138465 A CN1138465 A CN 1138465A CN 95106942 A CN95106942 A CN 95106942A CN 95106942 A CN95106942 A CN 95106942A CN 1138465 A CN1138465 A CN 1138465A
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Abstract
A medicine for curing epilepsy with total effective rate up to 95% and less by-effect is prepared from 18 Chinese-medicinal materials such as scorpion, centipede, gastrodia tuber, arisaema tuber, curcuma root, etc. through immersing in wine, baking or drying in air, proportional mixing, sterilization and making wasty pill.
Description
The present invention relates to a kind of medicine for the treatment of epileptics, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the present invention relates to the preparation method of this medicine.
Epileptics is the stubborn disease of serious harm human health, its sickness rate is about 5 ‰, the trend that increases is year by year arranged in recent years, the medicine of at present domestic and international clinical treatment epileptics is still based on phenytoin sodium, phenobarbital, sodium valproate, carbamazepine use in conjunction, but serious toxic and side effects need be taken and exist to said medicine all the life.Major side effects has following 4 points.
1, takes for a long time and be prone to hematopoietic function obstacle, anemia, leukopenia etc.;
2, infringement hepatic and renal function;
3, there are drowsiness, hypomnesis, reaction pure late;
4, can only controlling symptoms, can not effect a radical cure, in case being prone to, drug withdrawal breaks out.
The objective of the invention is to for epileptic patient provide a kind of have efficient, nontoxic, treating both the principal and secondary aspects of a disease, epilepsy spectrum wide, act on persistent therapeutic agent; The present invention is to epilepsy grand mal, petit mal, and psychomotor attack all has extraordinary curative effect; Especially to intractable epilepsy or obey Western medicine for a long time invalid patient has specially good effect.
The present invention also aims to provide the preparation method of epilepsy therapy agent.
Solution of the present invention is based on pathogenetic understanding and the Therapeutic Principle of motherland's medical science to epileptics, achieve with reference to modern pharmacological research, from motherland's medical treasure-house, filter out have the supplementing the brain marrow, medicine that clear disease heat, tranquilizing mind, town are twitched, principle according to traditional Chinese medical science principle-method-recipe-medicines is carried out prescription, compatibility, make it give full play to the effect that waking up the patient from unconsciousness by clearing away phlegm, the painful endogenous wind stopping in town, nourishing blood to tranquillize the mind, beneficial brain consolidate, thereby stop the generation and the diffusion of healthy cerebral tissue towards periphery of the special high-frequency electric wave of epilepsy, effectively the generation and the development of Taking Control of Epilepsy disease.
Medicine of the present invention is made by following component.(consumption is a weight portion).Scorpio 100-200 part Scolopendra 80-160 part flying worm 30-60 part Rhizoma Arisaematis 80-160 part Radix Curcumae 50-100 part Rhizoma Coptidis 120-240 part Concretio silicea Bambusae seu schizostachyi 80-160 part Arisaema Cum Bile 30-60 part Concha Haliotidis 60-160 part Alumen 50-100 part Radix Et Rhizoma Rhei 80-160 part Cinnabaris 30-60 part succinum 30-60 part Lapis Chloriti 100-200 part Placenta Hominis 100-200 part Medulla caprae seuovis powder 100-200 part Cornu Bubali powder 80-160 part Rhizoma Gastrodiae 150-300 part
The prescription preferred weight ratio range of preparation medicine of the present invention is: the blue or green chlorite schist 120-140 of full worm 120-160 part centipede 90-120 part flying worm 30-40 part rhizoma arisaematis 90-120 part root tuber of aromatic turmeric 60-80 part coptis 160-200 part Concretio Silicea Bambusae 100-120 part courage star 30-40 part shell of seaear 100-120 part alum 60-90 part rheum officinale 90-120 part cinnabar 30-40 part amber 40-55 part part dried human placenta 120-160 part sheep brain powder 120-180 part Cornu Bubali powder 90-120 part rhizoma Gastrodiae 180-250 part
The optimum weight proportioning of medicine of the present invention is: 200 parts in 100 parts of Rhizoma Gastrodiaes of 165 parts of Cornu Bubali powders of 130 parts of Medulla caprae seuovis powder of 110 parts of Placenta Hominiss of 50 parts of Lapis Chloriti of 30 parts of succinums of 110 parts of Cinnabaris of 75 parts of Radix Et Rhizoma Rhei of 100 parts of Alumens of 40 parts of Concha Haliotidis of 100 parts of Arisaema Cum Bile of 190 parts of Concretio silicea Bambusae seu schizostachyi of 70 portions of Rhizoma Coptidis of 100 portions of Radix Curcumaes of 40 parts of Rhizoma Arisaematiss of 115 portions of flying worms of 110 parts of Scolopendras of Scorpio
The medicine of this treatment epileptics can be said any dosage form on the pharmaceutics.
Above-mentioned each component is made medicine production method of the present invention is:
1, get Medulla caprae seuovis earlier, Placenta Hominis is put and is dried post-treatment in the baking oven under 80-100 ℃ and be broken into 120 order fineness.
2, get Lapis Chloriti on charcoal fire, forge red, forge, upright both having put in the Chinese liquor taken out Lapis Chloriti after 30 minutes from wine liquid, processing powder is broken into 120 order fineness.
3, get Scorpio, Scolopendra, flying worm, Rhizoma Arisaematis, Radix Curcumae, Rhizoma Coptidis, Concretio silicea Bambusae seu schizostachyi, Arisaema Cum Bile, Concha Haliotidis, Alumen, Radix Et Rhizoma Rhei, Cinnabaris, succinum, Cornu Bubali is ground into 120 order fineness after Rhizoma Gastrodiae is air-dry.
4, with above-mentioned whole powder components by after the described mixed, be rolled onto the watered pill, under 80-100 ℃, carried out the ripening sterilization treatment 15-30 minute, the watered pill of the epilepsy that both can obtain medical treatment.
Clinical drug of the present invention uses the result to show that following advantage is arranged.
1, medicine of the present invention is made up of the Chinese herbal medicine compatibility entirely, meets the theory of Chinese medical science principle, makes full use of the comprehensive function treatment epileptics of the Chinese herbal medicine of respectively distinguishing the flavor of, and is nontoxic without any side effects.
2, the epilepsy spectrum is wide, and to epilepsy grand mal, petit mal, psychomotor attack is also effective, especially the invalid patient of clothes Western medicine of a specified duration is had specially good effect.It is present more satisfactory antiepileptic.
3, the present invention can take stopgap measures and more can effect a permanent cure, contains each abundant seed amino acid and polypeptide class in the Medulla caprae seuovis powder, Placenta Hominis, can the nutrition brain, improve the brain cell metabolism, and the excited threshold value of the focus normal surrounding tissue that can raise.
4, the epileptic both can act on separately, also can unite use with other antiepileptic, but can significantly reduce the use amount and the side effect of common antiepileptic, and therapeutic effect is obviously increased.
5, medicine of the present invention source abundance is cheap, easy to use, evident in efficacy, is easy to promote.
For showing the therapeutic effect of medicine of the present invention to epileptics, the present invention carries out systematic observation to 384 routine patients, and selection medical history, the state of an illness, age, sex and suitable epileptic's 160 examples of former Therapeutic Method are matched group, it all is the case of selecting at special outpatient clinic, " antiepileptic therapeutic evaluation standard " by Ministry of Public Health in January, 1988 announcement drafted, with reference to 1979 " the epilepsy criterion of therapeutical effect that the Qingdao academic conference is formulated ".Male 229 examples are organized in treatment.Account for 59.64%, women 155 examples account for 40.36%; Matched group man 91 examples account for 56.88%, and women 69 examples account for 43.12%.The outbreak type: the treatment group, grand mal 299 examples account for 77.44%, and petit mal 51 examples account for 13.28%, and psychomotor seizure 25 examples account for 9.38%; Matched group: grand mal 109 examples, account for 66.88%, petit mal 28 examples account for 17.50%, and psychomotor seizure 25 examples account for 15.63%.Treatment group clothes medicine of the present invention.Matched group is obeyed phenytoin sodium, sodium valproate, carbamazepine routinely, observes four courses of treatment, and three months is a course of treatment.
Instructions of taking: all case is oral medication, the spirit of treatment group clothes epilepsy, and each clothes 4 grams of person are to 5 grams more than 16 years old, 10 years old to 15 years old person poison time clothes, 3 to 4 grams, each clothes 2 to 3 grams of 5-9 year person, 2 years old-4 years old each clothes 1 to 2 gram of person, person below 2 years old obeys 0.5 gram to 1 gram, is day clothes 3 times.Matched group: each clothes 0.15 gram of phenytoin sodium adult, every day 3 times, 5 to 10 milligrams of children (kilogram/day); Sodium valproate be grown up each 0.3 to 0.9 the gram, every day 3 times, 25 to 35 milligrams of children (kilogram/day); Carbamazepine be grown up each 0.2 to 0.3 the gram, every day 3 times, 15 to 20 milligrams of children (kilogram/day).
The clinical analysis result is as table 1-4
The spirit of table 1 epilepsy is compared with phenytoin sodium treatment epilepsy grand mal curative effect
| The treatment grouping | The example number | Produce effects | Effectively | Improve | Invalid | Effective percentage |
| Example % | Example % | Example % | Example % | Example % | ||
| Epilepsy spirit group phenytoin sodium group | ??267 ??85 | ??209???78.28 ??33????38.32 | ????33????12.36 ????17????2.0 | ????16????5.99 ????11????12.94 | ????9?????3.37 ????24????28.24 | ????258??96.63 ????61???71.76 |
There is highly significant difference P＜0.001
The spirit of table 2 epilepsy is compared with phenylvaleric acid sodium treatment petit mal epilepsy curative effect
| The treatment grouping | The example number | Produce effects | Effectively | Improve | Invalid | Effective percentage |
| Example % | Example % | Example % | Example % | Example % | ||
| Epilepsy spirit group sodium valproate group | ????87 ????52 | ????61????70.11 ????21????40.38 | ????14????16.09 ????6?????11.54 | ????6???6.90 ????11??21.15 | ????6????6.90 ????14???26.92 | ????81??93.10 ????38??73.08 |
There were significant differences in P＜0.001
Table 3 epilepsy smart card horse Xiping treatment psychomotor attack curative effect relatively
| The treatment grouping | The example number | Produce effects | Effectively | Improve | Invalid | Effective percentage |
| Example % | Example % | Example % | Example % | Example % | ||
| Epilepsy spirit group carbamazepine group | 30 23 | ????19????63.33 ????5?????21.74 | ????5????16.67 ????7????30.43 | ????3???10 ????3???13.04 | ????3????10 ????8????34.78 | ????27??90 ????15??65.22 |
There is highly significant difference P＜0.001
Table 4 epilepsy spirit treatment rare type epilepsy efficacy analysis
| The outbreak type | The example number | Produce effects | Effectively | Improve | Invalid | Effective percentage |
| Example | Example | Example | Example | Example % | ||
| The stunned epilepsy acroesthesia of infantile spasms epilepsy eye epilepsy sexual intercourse perception epilepsy HHE syndrome | ????12 ????11 ????9 ????7 ????3 ????3 | ????5 ????7 ????5 ????5 ????2 ????1 | ????3 ????2 ????2 ????1 ????0 ????1 | ????2 ????1 ????1 ????1 ????1 ????0 | ????2 ????1 ????1 ????0 ????0 ????1 | ????10??83.33 ????10??90.90 ????8???68.09 ????3???100.00 ????3???100.00 ????2???66.67 |
| Add up to | ????45 | ????25 | ????9 | ????6 | ????5 | ????40??38.89 |
Learn by statistics and handle, reduced by 49.92% than abnormal EEG rate before the treatment after the treatment, natural rate of interest has improved 1.21 times.Show that the epilepsy spirit has the improvement effect to epileptic's electroencephalogram.
Routine blood test before and after the treatment, routine urinalysis, electrocardiogram, Chest X-rays check result there is no abnormal change.Liver function, renal function there is no abnormal change.
One, convulsion experimental results show that
The epilepsy spirit has the highly significant antagonism to the mice electrofit, and stronger than phenytoin sodium; Mice pentetrazole convulsions also there is the highly significant antagonism, and stronger than sodium valproate: the rat audiogenic convulsion also there is the highly significant antagonism, and strong through carbamazepine.The zoopery result is consistent with clinical observation.
Two, pharmacology and pathology zoopery show
Acute toxicity testing: the LD50 of oral administration is 465.36 ± 24.37mg/Kg.With three dosage groups, three kinds of animals are observed in the long term toxicity test of half a year the animal ordinary circumstance, body weight, breathing, heart rate hepatic and renal function, hemogram and pathologic finding and matched group relatively there is no unusually, and by measuring the toxic effect attenuation rate, toxic effect half-life and cumulative coefficient, prove do not have the property accumulated, successive administration unexpected drug withdrawal in 6 months do not see yet and gives up the card shape.
Test statistics shows, with medicament of the present invention 384 routine epileptics is treated clinical observation and has obtained significant curative effect person 289 examples, accounts for 75.26%; Responder's 52 examples account for 13.54%; Improver's 25 examples account for 6.510%; Total effective rate reaches 95.31%.
Embodiment:
Take by weighing raw material by following proportioning:
Scorpio 150 gram Scolopendras 95 gram flying worms 40 grams
Rhizoma Arisaematis 100 gram Radix Curcumaes 60 gram Rhizoma Coptidis 120 grams
Concretio silicea Bambusae seu schizostachyi 150 gram Arisaema Cum Bile 40 gram Concha Haliotidis 110 grams
Alumen 70 gram Radix Et Rhizoma Rhei 120 gram Cinnabaris 40 grams
Succinum 50 gram Lapis Chloriti 150 gram Placenta Hominiss 160 grams
Medulla caprae seuovis 170 gram Cornu Bubali powders 80 gram Rhizoma Gastrodiaes 160 grams
Placenta Hominis, Medulla caprae seuovis put in the baking oven dry under 80 ℃ of conditions, the processing powder crystal becomes 120 order fineness; Lapis Chloriti is forged in charcoal fire, dropped in the 60 degree Chinese liquor and quench, be ground into 120 order fineness; Scorpio, flying worm, Scolopendra, Rhizoma Arisaematis, Radix Curcumae, Rhizoma Coptidis, Concretio silicea Bambusae seu schizostachyi, Arisaema Cum Bile, Concha Haliotidis, Alumen, Radix Et Rhizoma Rhei, Cinnabaris, succinum, Rhizoma Gastrodiae, Cornu Bubali are ground into 120 order fineness after air-dry, above-mentioned powder is mixed, ripening under 85 ℃ of temperature, sterilization 30 minutes, taking-up adds the watered pill that water is made 0.2 centimetre of diameter.
Claims (6)
1, a kind of medicine for the treatment of epileptics is characterized in that it is the medicament of being made by the following weight proportion raw material: Scorpio 100-200 part joy centipede 80-160 part flying worm 30-60 part Rhizoma Arisaematis 80-160 part Radix Curcumae 50-100 part Rhizoma Coptidis 120-240 part Concretio silicea Bambusae seu schizostachyi 80-160 part Arisaema Cum Bile 30-60 part Concha Haliotidis 60-160 part Alumen 50-100 part Radix Et Rhizoma Rhei 80-160 part Cinnabaris 30-60 part succinum 30-60 part Lapis Chloriti 100-200 part Placenta Hominis 100-200 part Medulla caprae seuovis powder 100-200 part Cornu Bubali powder 80-160 part Rhizoma Gastrodiae 150-300 part
2, the medicine of treatment epileptics according to claim 1 is characterized in that the weight proportion of each raw material is: Scorpio 120-160 part Scolopendra 90-120 part flying worm 30-40 part Rhizoma Arisaematis 90-120 part Radix Curcumae 60-80 part Rhizoma Coptidis 160-200 part Concretio silicea Bambusae seu schizostachyi 100-120 part Arisaema Cum Bile 30-40 part Concha Haliotidis 100-120 part Alumen 60-90 part Radix Et Rhizoma Rhei 90-120 part Cinnabaris 30-40 part succinum 40-55 part Lapis Chloriti 120-140 part Placenta Hominis 120-160 part Medulla caprae seuovis powder 120-180 part Cornu Bubali powder 90-120 part Rhizoma Gastrodiae 180-250 part
3, the medicine of treatment epileptics according to claim 1 is characterized in that the weight proportion of each raw material is: 200 parts in 100 parts of Rhizoma Gastrodiaes of Scorpio 110 parts of joys, 165 parts of Cornu Bubali powders of 130 parts of Medulla caprae seuovis powder of 110 parts of Placenta Hominiss of 50 parts of Lapis Chloriti of 30 parts of succinums of 110 parts of Cinnabaris of 75 parts of Radix Et Rhizoma Rhei of 100 parts of Alumens of 40 parts of Concha Haliotidis of 100 parts of Arisaema Cum Bile of 190 parts of Concretio silicea Bambusae seu schizostachyi of 70 portions of Rhizoma Coptidis of 100 portions of Radix Curcumaes of 40 parts of Rhizoma Arisaematiss of 115 portions of flying worms of centipede
4,, it is characterized in that said medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1,2 or 3 described treatment epilepticss.
5, the medicine of treatment epilepsy according to claim 4 is characterized in that said medicament is a watered pill.
6, the preparation method of the medicine of the described treatment epileptics of claim 5 is characterized in that getting Placenta Hominis, Medulla caprae seuovis and puts in the drying baker 80-100 ℃ of oven dry down, and processing powder is broken into 120 order fineness; With Lapis Chloriti on charcoal fire, forge red, forge, upright both the input in the Chinese liquor quenched, processing powder is broken into 120 order fine powders; Scorpio, flying worm, joy centipede, Rhizoma Arisaematis, Radix Curcumae, Rhizoma Coptidis, Concretio silicea Bambusae seu schizostachyi, Arisaema Cum Bile, Concha Haliotidis, Alumen, Radix Et Rhizoma Rhei, Cinnabaris, succinum, Cornu Bubali, Rhizoma Gastrodiae are ground into 120 order fine powders after air-dry, with above-mentioned whole powder components by after the described mixed, carried out ripening, sterilization treatment 30 minutes under 80-100 ℃ of temperature, it is existing to make 0.2 centimetre of big watered pill of diameter at Jia Shui.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95106942A CN1054762C (en) | 1995-06-16 | 1995-06-16 | Medicine for treatment of epilepsy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95106942A CN1054762C (en) | 1995-06-16 | 1995-06-16 | Medicine for treatment of epilepsy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1138465A true CN1138465A (en) | 1996-12-25 |
| CN1054762C CN1054762C (en) | 2000-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95106942A Expired - Fee Related CN1054762C (en) | 1995-06-16 | 1995-06-16 | Medicine for treatment of epilepsy |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061552C (en) * | 1997-10-28 | 2001-02-07 | 董国良 | Epilepsy recovering pill and preparing process thereof |
| CN1069059C (en) * | 1999-08-11 | 2001-08-01 | 唐玉厚 | Chinese patent medicine for treating epilepsy |
| CN102406844A (en) * | 2011-07-11 | 2012-04-11 | 李保明 | Chinese medicinal preparation for treating epilepsy and its preparation method |
| CN102813888A (en) * | 2012-08-03 | 2012-12-12 | 李广仁 | Chinese herbal composition for treating epilepsy |
| CN106039211A (en) * | 2016-07-01 | 2016-10-26 | 尚石斗 | Nerve-calming and convulsion-relieving granules and preparation method thereof |
| CN108339093A (en) * | 2018-05-18 | 2018-07-31 | 重庆跃龙生物制药有限公司 | Chinese medicine composition and preparation method thereof for treating epileptics |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057584A (en) * | 1990-06-15 | 1992-01-08 | 李文琪 | The preparation method of Chinese herbal medicine " Dianxianling " mixture (for epilepsy) |
-
1995
- 1995-06-16 CN CN95106942A patent/CN1054762C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061552C (en) * | 1997-10-28 | 2001-02-07 | 董国良 | Epilepsy recovering pill and preparing process thereof |
| CN1069059C (en) * | 1999-08-11 | 2001-08-01 | 唐玉厚 | Chinese patent medicine for treating epilepsy |
| CN102406844A (en) * | 2011-07-11 | 2012-04-11 | 李保明 | Chinese medicinal preparation for treating epilepsy and its preparation method |
| CN102406844B (en) * | 2011-07-11 | 2014-02-12 | 李保明 | Traditional Chinese medicine preparation for treating epilepsy and its preparation method |
| CN102813888A (en) * | 2012-08-03 | 2012-12-12 | 李广仁 | Chinese herbal composition for treating epilepsy |
| CN106039211A (en) * | 2016-07-01 | 2016-10-26 | 尚石斗 | Nerve-calming and convulsion-relieving granules and preparation method thereof |
| CN108339093A (en) * | 2018-05-18 | 2018-07-31 | 重庆跃龙生物制药有限公司 | Chinese medicine composition and preparation method thereof for treating epileptics |
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| Publication number | Publication date |
|---|---|
| CN1054762C (en) | 2000-07-26 |
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