CN108339093A - Chinese medicine composition and preparation method thereof for treating epileptics - Google Patents
Chinese medicine composition and preparation method thereof for treating epileptics Download PDFInfo
- Publication number
- CN108339093A CN108339093A CN201810481533.4A CN201810481533A CN108339093A CN 108339093 A CN108339093 A CN 108339093A CN 201810481533 A CN201810481533 A CN 201810481533A CN 108339093 A CN108339093 A CN 108339093A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- chinese medicine
- radix
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 68
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000001037 epileptic effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 14
- 206010004542 Bezoar Diseases 0.000 claims abstract description 13
- 241000258920 Chilopoda Species 0.000 claims abstract description 13
- 240000004307 Citrus medica Species 0.000 claims abstract description 13
- 241000756943 Codonopsis Species 0.000 claims abstract description 13
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 13
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 13
- 241000545744 Hirudinea Species 0.000 claims abstract description 13
- 241000157352 Uncaria Species 0.000 claims abstract description 13
- 229940037003 alum Drugs 0.000 claims abstract description 13
- 229910052956 cinnabar Inorganic materials 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 241000270273 Ptyas dhumnades Species 0.000 claims abstract description 12
- 239000000706 filtrate Substances 0.000 claims abstract description 12
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims abstract description 7
- 206010015037 epilepsy Diseases 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000007654 immersion Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 241000270295 Serpentes Species 0.000 claims 1
- 230000036461 convulsion Effects 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 13
- 206010010904 Convulsion Diseases 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 9
- 208000024891 symptom Diseases 0.000 abstract description 8
- 239000006260 foam Substances 0.000 abstract description 6
- 208000008238 Muscle Spasticity Diseases 0.000 abstract description 5
- 208000018198 spasticity Diseases 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 206010028347 Muscle twitching Diseases 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 4
- 230000001151 other effect Effects 0.000 abstract description 4
- 230000002936 tranquilizing effect Effects 0.000 abstract description 4
- 230000007306 turnover Effects 0.000 abstract description 4
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 3
- 208000014644 Brain disease Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 208000029767 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000825107 Hierochloe Species 0.000 description 1
- 235000015466 Hierochloe odorata Nutrition 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 201000003102 mental depression Diseases 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/28—Mercury; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/10—Peat; Amber; Turf; Humus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of Chinese medicine compositions and preparation method thereof for treating epileptics.The raw material of Chinese medicine composition includes full worm, cinnabar, tabasheer, amber, earthworm, mother-of-pearl, alum, radix bupleuri, Rhizoma Gastrodiae, Radix Glycyrrhizae, centipede, Radix Curcumae, leech, Radix Rehmanniae, Radix Codonopsis, Radix Salviae Miltiorrhizae, method summer, zaocys dhumnade, cow-bezoar, the coptis, the dried immature fruit of citron orange, the shell of seaear and uncaria.Preparation method:Each raw material component is weighed in proportion, is crushed, is soaked after cleaning;Extraction is decocted later, is filtered and is collected filtrate;Filtrate is condensed into medicinal extract, obtains Chinese medicine composition.Chinese medicine composition of the present invention has excellent qi and activate blood circulation, tranquillizing the mind by relieving convulsion and activating collaterals and eliminating stagnation and other effects, there is confrontation function to various convulsions, the whole body that can significantly improve epileptic twitches, spits out white foams, general spasticity, two the symptoms such as turn over, significantly reduce frequency of disease development and morbidity duration, and safe without toxic side effect;In addition, Chinese medicine composition of the present invention is easy to use, there is good commercial promise.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to a kind of Chinese medicine composition and its system for treating epileptics
Preparation Method.
Background technology
Epilepsy, " epilepsy " or " epilepsy " being commonly called as are the electric discharges of cerebral neuron paroxysmal abnormality, are caused of short duration big
A kind of chronic disease of brain disorder.It is shown according to Chinese cri dernier cri disease data, the overall illness rate of domestic epilepsy is
7.0 ‰, annual morbidity is that have the activity epilepsy illness rate of breaking-out in 28.8/10 ten thousand, 1 year be 4.6 ‰.Estimation is Chinese about accordingly
There is 9,000,000 or so epileptic, wherein 500~6,000,000 be movable Patients with Epilepsy, while newly increasing epileptic about every year
400000, have become the second largest common disease that neurology department is only second to headache in Chinese epilepsy.
Such disease common sympton is shown as:The disturbance of consciousness for occurring suddenly and stopping suddenly, whole body twitch, mouth are spat white
Foam, general spasticity, two turn over, such as ordinary person after revival.The reason of causing epilepsy is various, and common reason has with poisoning, lacks
Oxygen, wound, infection, brain diseases, congenital disorders, metabolic disease, cardiovascular and cerebrovascular disease etc..Currently, the treatment of such disease
Means are mostly based on western medicine, such as carbamazepine, epilepsy amine;Western medicine and medical practitioners have the excellent of it in terms of controlling epileptic attack
Gesture, but too strong inhibiting effect can make cerebral nerve function by toxic side effect;It not only cannot thoroughly effect a radical cure epilepsy, be not achieved
The purpose for the treatment of, and its side effect is big, drug dependence is strong, generates what mental depression, IQ, dysnoesia etc. can not avoid
Side effect.
Based on this, study a kind of novel, safe without toxic side effect and can effectively, the treatment of safety or alleviate epileptics
Drug have very important significance.
Invention content
For the defects in the prior art, the present invention is intended to provide it is a kind of for treat epileptics Chinese medicine composition and its
Preparation method.Chinese medicine composition provided by the invention has excellent qi and activate blood circulation, tranquillizing the mind by relieving convulsion and activating collaterals and eliminating stagnation and other effects,
Have confrontation function to various convulsions, the whole body that can significantly improve epileptic twitches, spits out white foams, general spasticity, two
It the symptoms such as turns over, significantly reduces frequency of disease development and morbidity duration, and safe without toxic side effect;In addition, Chinese medicine provided by the invention
Composition is easy to use, and cost is relatively low, has good commercial promise.
For this purpose, the present invention provides the following technical solutions:
In a first aspect, the present invention provide it is a kind of for treating the Chinese medicine composition of epileptics, raw material components by weight,
Including:Complete 20~30 parts by weight of worm, 10~15 parts by weight of cinnabar, 10~20 parts by weight of tabasheer, 10~20 parts by weight of amber,
Imperial 10~20 parts by weight, 10~15 parts by weight of mother-of-pearl, 20~30 parts by weight of radix bupleuri, 25~30 parts by weight of Radix Glycyrrhizae, centipede 10~
20 parts by weight, 15~20 parts by weight of Radix Curcumae, 15~25 parts by weight of leech, 20~25 parts by weight of Radix Rehmanniae, 20~30 parts by weight of Radix Codonopsis,
25~30 parts by weight of Radix Salviae Miltiorrhizae, 20~25 parts by weight of method summer, 10~25 parts by weight of cow-bezoar, 15~25 parts by weight of the coptis, the shell of seaear 10
20~30 parts by weight of~15 parts by weight and uncaria.
Preferably, raw material components further include:20~30 parts by weight of Rhizoma Gastrodiae, 10~20 parts by weight of zaocys dhumnade, the dried immature fruit of citron orange 15~20
5~10 parts by weight of parts by weight and alum.
Preferably, Chinese medicine composition is made of following raw material components:25 parts by weight of full worm, 12 parts by weight of cinnabar, tabasheer
16 parts by weight, 15 parts by weight of amber, 15 parts by weight of earthworm, 12 parts by weight of mother-of-pearl, 8 parts by weight of alum, 25 parts by weight of radix bupleuri, day
Numb 25 parts by weight, 30 parts by weight of Radix Glycyrrhizae, 15 parts by weight of centipede, 18 parts by weight of Radix Curcumae, 20 parts by weight of leech, 23 parts by weight of Radix Rehmanniae,
25 parts by weight of Radix Codonopsis, 26 parts by weight of Radix Salviae Miltiorrhizae, 22 parts by weight of method summer, 15 parts by weight of zaocys dhumnade, 10 parts by weight of cow-bezoar, 20 weight of the coptis
Part, 25 parts by weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria.
Preferably, Chinese medicine composition is made of following raw material components:30 parts by weight of full worm, 10 parts by weight of cinnabar, tabasheer
20 parts by weight, 10 parts by weight of amber, 20 parts by weight of earthworm, 10 parts by weight of mother-of-pearl, 10 parts by weight of alum, 20 parts by weight of radix bupleuri,
30 parts by weight of Rhizoma Gastrodiae, 25 parts by weight of Radix Glycyrrhizae, 20 parts by weight of centipede, 15 parts by weight of Radix Curcumae, 25 parts by weight of leech, 20 weight of Radix Rehmanniae
Part, 30 parts by weight of Radix Codonopsis, 25 parts by weight of Radix Salviae Miltiorrhizae, 25 parts by weight of method summer, 10 parts by weight of zaocys dhumnade, 25 parts by weight of cow-bezoar, the coptis 15
Parts by weight, 30 parts by weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria.
Second aspect, the present invention provide a kind of preparation method of Chinese medicine composition, include the following steps:S101:In proportion
Each raw material component is weighed, crushes after cleaning, soaks later;S102:Boil the drug use after immersion by intense fire 5~
15min, then exchange of notes fire heat 60~200min, filter and collect filtrate;S103:Relative density is when filtrate is condensed into 70 DEG C
1.10~1.20 medicinal extract, obtains Chinese medicine composition.
Preferably, in S101, the water of addition is 10~20 times of raw material components gross mass, soaking time be 10min~
20min。
Preferably, in S101, each raw material component is crushed to 60~100 mesh.
It can pharmaceutically be connect it should be noted that Chinese medicine composition prepared by the above method can be further prepared into as needed
The dosage form received.In addition, also belonging to protection scope of the present invention as drug made of active constituent using above-mentioned Chinese medicine composition.Pass through
It by above-mentioned Chinese medicine composition, is prepared after directly preparing or being added pharmaceutically acceptable auxiliary material, can be made into and any pharmaceutically may be used
The dosage form of receiving.Include by taking external preparation as an example:Solution, patch, vina, tincture, gelling agent, liniment, aerosol, spraying
Agent, ointment, suppository and plastics.The drug of above-mentioned various dosage forms can be prepared according to the conventional method of pharmaceutical field.
In clinical application, the dosage of Chinese medicine composition provided by the invention is generally each 2g, three times a day.
The third aspect, Chinese medicine composition provided by the invention is in preparing treatment epilepsy medicament and/or medicated premix
Application.
The above technical solution of the present invention has the following advantages over the prior art:
(1) applicant has found by numerous studies:Chinese medicine composition provided by the invention has excellent qi and activate blood circulation, town
Frightened tranquilizing the mind and activating collaterals and eliminating stagnation and other effects have confrontation function to various convulsions, and the whole body that can significantly improve epileptic is taken out
Jerk, spit out white foams, general spasticity, two the symptoms such as turn over, significantly reduce frequency of disease development and morbidity duration, and safe and non-toxic secondary make
With;In addition, Chinese medicine composition provided by the invention is easy to use, cost is relatively low, has good commercial promise.
(2) preparation method provided by the invention is used, the same of each bulk pharmaceutical chemicals active constituent can retained to greatest extent
When, the active ingredient in each raw medicinal material can be fully released, to make the Chinese medicine composition being finally prepared not
Only there is good drug effect, and be easy to absorb, and then be rapidly achieved the purpose for improving epileptics.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Specific implementation mode
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical scheme of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.
Test material as used in the following examples is unless otherwise specified to be commercially available from conventional reagent shop.
Quantitative test in following embodiment, is respectively provided with three repeated experiments, and data are the average value of three repeated experiments
Or mean+SD.
It is full worm as used in the following examples, cinnabar, tabasheer, amber, earthworm, mother-of-pearl, alum, radix bupleuri, Rhizoma Gastrodiae, sweet
Grass, centipede, Radix Curcumae, leech, Radix Rehmanniae, Radix Codonopsis, Radix Salviae Miltiorrhizae, method summer, zaocys dhumnade, cow-bezoar, the coptis, the dried immature fruit of citron orange, the shell of seaear and uncaria accord with
Close the pertinent regulations under Chinese Pharmacopoeia (version in 2017) each medicinal material item of text.Before feeding intake, by identification, ingredients is in kind
It is consistent with title, quality complies with standard.
The present invention provides a kind of Chinese medicine composition for treating epileptics, which is characterized in that raw material components are by weight
Meter, including:20~30 parts by weight of full worm, 10~15 parts by weight of cinnabar, 10~20 parts by weight of tabasheer, 10~20 weight of amber
Part, 10~20 parts by weight of earthworm, 10~15 parts by weight of mother-of-pearl, 20~30 parts by weight of radix bupleuri, 25~30 parts by weight of Radix Glycyrrhizae, centipede
10~20 parts by weight, 15~20 parts by weight of Radix Curcumae, 15~25 parts by weight of leech, 20~25 parts by weight of Radix Rehmanniae, 20~30 weight of Radix Codonopsis
Measure part, 25~30 parts by weight of Radix Salviae Miltiorrhizae, 20~25 parts by weight of method summer, 10~25 parts by weight of cow-bezoar, 15~25 parts by weight of the coptis, Shi Jue
20~30 parts by weight of bright 10~15 parts by weight and uncaria;And raw material components preferably further include 20~30 parts by weight of Rhizoma Gastrodiae, zaocys dhumnade
5~10 parts by weight of 10~20 parts by weight, 15~20 parts by weight of the dried immature fruit of citron orange and alum.
In addition, for the Chinese medicine composition of the present invention, the present invention specially devises preparation method, includes the following steps:
S101:Weigh each raw material component in proportion, clean after be crushed to 60~100 mesh, soak later 10min~
20min;Wherein, the water of addition is 10~20 times of raw material components gross mass.
S102:Boil the drug use after immersion by intense fire 5~15min, then exchange of notes fire heats 60~200min, filtering is simultaneously
Collect filtrate.
S103:The medicinal extract that relative density is 1.10~1.20 when filtrate is condensed into 70 DEG C, obtains Chinese medicine composition.
It illustrates With reference to embodiment:
Embodiment one
The present embodiment provides a kind of Chinese medicine compositions for treating epileptics, are prepared by following raw material components:Entirely
25 parts by weight of worm, 12 parts by weight of cinnabar, 16 parts by weight of tabasheer, 15 parts by weight of amber, 15 parts by weight of earthworm, 12 weight of mother-of-pearl
Part, 8 parts by weight of alum, 25 parts by weight of radix bupleuri, 25 parts by weight of Rhizoma Gastrodiae, 30 parts by weight of Radix Glycyrrhizae, 15 parts by weight of centipede, 18 weight of Radix Curcumae
Part, 20 parts by weight of leech, 23 parts by weight of Radix Rehmanniae, 25 parts by weight of Radix Codonopsis, 26 parts by weight of Radix Salviae Miltiorrhizae, 22 parts by weight of method summer, zaocys dhumnade 15
Parts by weight, 10 parts by weight of cow-bezoar, 20 parts by weight of the coptis, 25 parts by weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria.
By above-mentioned raw materials component, preparation method using the present invention prepares Chinese medicine composition:
S101:Each raw material component is weighed in proportion, is crushed to 100 mesh after cleaning, is soaked 10min later;Wherein, add
The water entered is 20 times of raw material components gross mass.
S102:Boil the drug use after immersion by intense fire 5min, then exchange of notes fire heats 200min, filters and collects filter
Liquid.
S103:The medicinal extract that relative density is 1.10 when filtrate is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment two
The present embodiment provides a kind of Chinese medicine compositions for treating epileptics, are prepared by following raw material components:Entirely
30 parts by weight of worm, 10 parts by weight of cinnabar, 20 parts by weight of tabasheer, 10 parts by weight of amber, 20 parts by weight of earthworm, 10 weight of mother-of-pearl
Part, 10 parts by weight of alum, 20 parts by weight of radix bupleuri, 30 parts by weight of Rhizoma Gastrodiae, 25 parts by weight of Radix Glycyrrhizae, 20 parts by weight of centipede, 15 weight of Radix Curcumae
Measure part, 25 parts by weight of leech, 20 parts by weight of Radix Rehmanniae, 30 parts by weight of Radix Codonopsis, 25 parts by weight of Radix Salviae Miltiorrhizae, 25 parts by weight of method summer, zaocys dhumnade
10 parts by weight, 25 parts by weight of cow-bezoar, 15 parts by weight of the coptis, 30 parts by weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria.
By above-mentioned raw materials component, preparation method using the present invention prepares Chinese medicine composition:
S101:Each raw material component is weighed in proportion, is crushed to 60 mesh after cleaning, is soaked 20min later;Wherein, add
The water entered is 10 times of raw material components gross mass.
S102:Boil the drug use after immersion by intense fire 15min, then exchange of notes fire heats 60min, filters and collects filter
Liquid.
S103:The medicinal extract that relative density is 1.20 when filtrate is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment three
The present embodiment provides a kind of Chinese medicine compositions for treating epileptics, are prepared by following raw material components:Entirely
25 parts by weight of worm, 12 parts by weight of cinnabar, 16 parts by weight of tabasheer, 15 parts by weight of amber, 15 parts by weight of earthworm, 12 weight of mother-of-pearl
Part, 8 parts by weight of alum, 25 parts by weight of radix bupleuri, 25 parts by weight of Rhizoma Gastrodiae, 30 parts by weight of Radix Glycyrrhizae, 15 parts by weight of centipede, 18 weight of Radix Curcumae
Part, 20 parts by weight of leech, 23 parts by weight of Radix Rehmanniae, 25 parts by weight of Radix Codonopsis, 26 parts by weight of Radix Salviae Miltiorrhizae, 22 parts by weight of method summer, zaocys dhumnade 15
Parts by weight, 10 parts by weight of cow-bezoar, 20 parts by weight of the coptis, 25 parts by weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria.
By above-mentioned raw materials component, preparation method using the present invention prepares Chinese medicine composition:
S101:Each raw material component is weighed in proportion, is crushed to 100 mesh after cleaning, is soaked 10min later;Wherein, add
The water entered is 20 times of raw material components gross mass.
S102:Boil the drug use after immersion by intense fire 5min, then exchange of notes fire heats 200min, filters and collects filter
Liquid.
S103:The medicinal extract that relative density is 1.10 when filtrate is condensed into 70 DEG C, obtains Chinese medicine composition.
Example IV
The present embodiment provides a kind of Chinese medicine compositions for treating epileptics, are prepared by following raw material components:Entirely
30 parts by weight of worm, 10 parts by weight of cinnabar, 20 parts by weight of tabasheer, 10 parts by weight of amber, 20 parts by weight of earthworm, 10 weight of mother-of-pearl
Part, 10 parts by weight of alum, 20 parts by weight of radix bupleuri, 30 parts by weight of Rhizoma Gastrodiae, 25 parts by weight of Radix Glycyrrhizae, 20 parts by weight of centipede, 15 weight of Radix Curcumae
Measure part, 25 parts by weight of leech, 20 parts by weight of Radix Rehmanniae, 30 parts by weight of Radix Codonopsis, 25 parts by weight of Radix Salviae Miltiorrhizae, 25 parts by weight of method summer, zaocys dhumnade
10 parts by weight, 25 parts by weight of cow-bezoar, 15 parts by weight of the coptis, 30 parts by weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria.
By above-mentioned raw materials component, preparation method using the present invention prepares Chinese medicine composition:
S101:Each raw material component is weighed in proportion, is crushed to 60 mesh after cleaning, is soaked 20min later;Wherein, add
The water entered is 10 times of raw material components gross mass.
S102:Boil the drug use after immersion by intense fire 15min, then exchange of notes fire heats 60min, filters and collects filter
Liquid.
S103:The medicinal extract that relative density is 1.20 when filtrate is condensed into 70 DEG C, obtains Chinese medicine composition.
In addition, the effect of in order to preferably evaluate each embodiment, carry out following experiment:
One, toxicity test
It is the small white mouse 80 (each 40 of male and female) of 18~22g to select weight, is divided into 4 groups, takes implementation of the present invention respectively
The Chinese medicine composition that example one to example IV is prepared.Specifically, the Chinese medicine composition 8g for taking the present invention, adds deionized water system
At concentrate 20mL, every small white mouse gives concentrate 1.2mL gavages, twice daily;Observation 30 days, small white mouse health are raw
It deposits, it is without any side effects;Blood picture, liver function, each organs and tissues state, the indifference compared with normal small white mouse is dissected and observed.
It is demonstrated experimentally that Chinese medicine composition provided by the invention is nontoxic.
Two, clinical test
All kinds of epileptics 400 are collected, each patient is accompanied by different degrees of whole body and twitches, spits out white foams, entirely
Body spasm, two the symptoms such as turn over, and illness frequency be up to 2 days it is primary.Specifically, patient is divided into 4 groups, every group 100,
The embodiment of the present invention one is taken respectively to the Chinese medicine composition 5 weeks of example IV, 2 times a day, every time by first group to the 4th group
3g;Curative effect is observed later, and measures the diminution degree of each patient's epileptics volume, it is specific as shown in table 1.
Curative effect is judged as:
It is effective:Compared with the intermittent time of breaking out before treatment, extends 1 year or more and do not send out author;It improves:Breaking-out completely control or
Seizure frequency reduces 60% or more, and disease time shortens every time, and symptom mitigates;It is poor:Seizure frequency reduces 60% or less.Its
In, total effective rate=obvious effective rate+improvement rate.
1 each embodiment patient epileptics symptom situation of change statistical form of table
| Case number of cases/name | Effective/name | Improvement/name | In vain/name | Total effective rate/% | |
| Embodiment one | 100 | 50 | 45 | 5 | 95 |
| Embodiment two | 100 | 55 | 42 | 3 | 97 |
| Embodiment three | 100 | 76 | 23 | 1 | 99 |
| Example IV | 100 | 70 | 28 | 2 | 98 |
Certainly, the case where being enumerated in addition to embodiment one to example IV, the type and weight percent of other raw material components,
Condition and parameter in preparation process etc. are also possible.It should be noted that each patient does not occur not over the course for the treatment of
Suitable symptom.
Chinese medicine composition provided by the invention has excellent qi and activate blood circulation, tranquillizing the mind by relieving convulsion and activating collaterals and eliminating stagnation and other effects,
Have confrontation function to various convulsions, the whole body that can significantly improve epileptic twitches, spits out white foams, general spasticity, two
It the symptoms such as turns over, significantly reduces frequency of disease development and morbidity duration, and safe without toxic side effect;In addition, Chinese medicine provided by the invention
Composition is easy to use, and cost is relatively low, has good commercial promise.
In the description of this specification, it is to be understood that reference term " one embodiment ", " is shown " some embodiments "
The description of example ", " specific example " or " some examples " etc. mean specific features described in conjunction with this embodiment or example, structure,
Material or feature are included at least one embodiment or example of the invention.In the present specification, above-mentioned term is shown
The statement of meaning property is necessarily directed to identical embodiment or example.Moreover, specific features, structure, material or the spy of description
Point may be combined in any suitable manner in any one or more of the embodiments or examples.In addition, without conflicting with each other,
Those skilled in the art can be by different embodiments or examples described in this specification and different embodiments or examples
Feature is combined.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changes, replacing and modification.
Claims (8)
1. a kind of for treating the Chinese medicine composition of epileptics, which is characterized in that raw material components by weight, including:
Complete 20~30 parts by weight of worm, 10~15 parts by weight of cinnabar, 10~20 parts by weight of tabasheer, 10~20 parts by weight of amber,
Imperial 10~20 parts by weight, 10~15 parts by weight of mother-of-pearl, 20~30 parts by weight of radix bupleuri, 25~30 parts by weight of Radix Glycyrrhizae, centipede 10~
20 parts by weight, 15~20 parts by weight of Radix Curcumae, 15~25 parts by weight of leech, 20~25 parts by weight of Radix Rehmanniae, 20~30 parts by weight of Radix Codonopsis,
25~30 parts by weight of Radix Salviae Miltiorrhizae, 20~25 parts by weight of method summer, 10~25 parts by weight of cow-bezoar, 15~25 parts by weight of the coptis, the shell of seaear 10
20~30 parts by weight of~15 parts by weight and uncaria.
2. the Chinese medicine composition according to claim 1 for treating epileptics, which is characterized in that further include:
20~30 parts by weight of Rhizoma Gastrodiae, 5~10 parts by weight of 10~20 parts by weight of zaocys dhumnade, 15~20 parts by weight of the dried immature fruit of citron orange and alum.
3. the Chinese medicine composition according to claim 2 for treating epileptics, which is characterized in that by following raw material components
It is made:
25 parts by weight of full worm, 12 parts by weight of cinnabar, 16 parts by weight of tabasheer, 15 parts by weight of amber, 15 parts by weight of earthworm, mother-of-pearl
12 parts by weight, 8 parts by weight of alum, 25 parts by weight of radix bupleuri, 25 parts by weight of Rhizoma Gastrodiae, 30 parts by weight of Radix Glycyrrhizae, 15 parts by weight of centipede, Radix Curcumae
18 parts by weight, 20 parts by weight of leech, 23 parts by weight of Radix Rehmanniae, 25 parts by weight of Radix Codonopsis, 26 parts by weight of Radix Salviae Miltiorrhizae, 22 parts by weight of method summer, crow
15 parts by weight of tip snake, 10 parts by weight of cow-bezoar, 20 parts by weight of the coptis, 25 weight of 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria
Measure part.
4. the Chinese medicine composition according to claim 2 for treating epileptics, which is characterized in that by following raw material components
It is made:
30 parts by weight of full worm, 10 parts by weight of cinnabar, 20 parts by weight of tabasheer, 10 parts by weight of amber, 20 parts by weight of earthworm, mother-of-pearl
It is 10 parts by weight, 10 parts by weight of alum, 20 parts by weight of radix bupleuri, 30 parts by weight of Rhizoma Gastrodiae, 25 parts by weight of Radix Glycyrrhizae, 20 parts by weight of centipede, strongly fragrant
Golden 15 parts by weight, 25 parts by weight of leech, 20 parts by weight of Radix Rehmanniae, 30 parts by weight of Radix Codonopsis, 25 parts by weight of Radix Salviae Miltiorrhizae, 25 parts by weight of method summer,
10 parts by weight of zaocys dhumnade, 25 parts by weight of cow-bezoar, 15 parts by weight of the coptis, 20 parts by weight of the dried immature fruit of citron orange, 10 parts by weight of the shell of seaear and uncaria 30
Parts by weight.
5. the preparation method of Claims 1 to 4 any one of them Chinese medicine composition, which is characterized in that include the following steps:
S101:Each raw material component is weighed in proportion, is crushed after cleaning, is soaked later;
S102:Boil the drug use after the immersion by intense fire 5~15min, then exchange of notes fire heats 60~200min, filtering is simultaneously
Collect filtrate;
S103:The medicinal extract that relative density is 1.10~1.20 when the filtrate is condensed into 70 DEG C, obtains the Chinese medicine composition.
6. the preparation method of the Chinese medicine composition described in claim 5, it is characterised in that:
In the S101, the water of addition is 10~20 times of the raw material components gross mass, soaking time be 10min~
20min。
7. the preparation method of the Chinese medicine composition described in claim 6, it is characterised in that:
In the S101, each raw material component is crushed to 60~100 mesh.
8. Claims 1 to 4 any one of them Chinese medicine composition is in preparing treatment epilepsy medicament and/or medicated premix
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810481533.4A CN108339093A (en) | 2018-05-18 | 2018-05-18 | Chinese medicine composition and preparation method thereof for treating epileptics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810481533.4A CN108339093A (en) | 2018-05-18 | 2018-05-18 | Chinese medicine composition and preparation method thereof for treating epileptics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108339093A true CN108339093A (en) | 2018-07-31 |
Family
ID=62955668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810481533.4A Pending CN108339093A (en) | 2018-05-18 | 2018-05-18 | Chinese medicine composition and preparation method thereof for treating epileptics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108339093A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5888318A (en) * | 1981-11-21 | 1983-05-26 | Moriyasu Kino | Natural total mineral agent |
| CN1138465A (en) * | 1995-06-16 | 1996-12-25 | 姜春水 | Medicine for treatment of epilepsy |
| CN1179321A (en) * | 1997-10-28 | 1998-04-22 | 董国良 | Epilepsy recovering pill and preparing process thereof |
| CN1954876A (en) * | 2006-10-11 | 2007-05-02 | 刘光跃 | Traditional Chinese medicine for treating epilepsy disease |
| CN101559195A (en) * | 2008-04-16 | 2009-10-21 | 苗卫萍 | Epilepsy therapy capsule and preparation method thereof |
| CN104208652A (en) * | 2014-10-09 | 2014-12-17 | 马俊安 | Traditional Chinese medicine for treating epilepsy and preparation method thereof |
-
2018
- 2018-05-18 CN CN201810481533.4A patent/CN108339093A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5888318A (en) * | 1981-11-21 | 1983-05-26 | Moriyasu Kino | Natural total mineral agent |
| CN1138465A (en) * | 1995-06-16 | 1996-12-25 | 姜春水 | Medicine for treatment of epilepsy |
| CN1179321A (en) * | 1997-10-28 | 1998-04-22 | 董国良 | Epilepsy recovering pill and preparing process thereof |
| CN1954876A (en) * | 2006-10-11 | 2007-05-02 | 刘光跃 | Traditional Chinese medicine for treating epilepsy disease |
| CN101559195A (en) * | 2008-04-16 | 2009-10-21 | 苗卫萍 | Epilepsy therapy capsule and preparation method thereof |
| CN104208652A (en) * | 2014-10-09 | 2014-12-17 | 马俊安 | Traditional Chinese medicine for treating epilepsy and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105770145A (en) | Medicinal composition with sleep improvement effect and preparation method for medicinal composition | |
| CN101559195B (en) | Epilepsy therapy capsule and preparation method thereof | |
| CN104013878B (en) | A kind of lavipeditum medicine vinegar and preparation method thereof for treating tinea pedis | |
| CN110585271A (en) | A Chinese medicinal oil drop for treating pharyngolaryngitis, and its preparation method | |
| CN102579647A (en) | Chinese medicinal oral liquid for treating Escherichia coli disease of poultry, and its preparation method | |
| CN102697935A (en) | Chinese medicinal particle for preventing and treating duck plague and preparation method thereof | |
| CN103055076B (en) | Pure Chinese medicinal composition for treating nosemosis of bees and preparation method of pure Chinese medicinal composition | |
| CN108434385A (en) | Chinese medicine composition and preparation method thereof for treating vertigo | |
| CN101732642A (en) | Medicament for treating flat wart | |
| CN104971132B (en) | It is a kind of for preventing and treating the Chinese materia medica preparation of long octopus Disease of skin fester | |
| CN108853201B (en) | Compound Chinese herbal medicine preparation, preparation method and application | |
| CN107007704A (en) | Subhealth treating liquid and its preparation method and application | |
| CN102247571A (en) | Medicament for tranquilizing, heat clearing and detoxifying and preparation method thereof | |
| CN102273495A (en) | Baofengjian | |
| CN103393954B (en) | A kind of ointment preparation method for rehabilitation after common peroneal nerve injury | |
| CN104352688B (en) | A kind of ring that is used for controls novel drug and the Chinese medicine preparation and preparation method of sequelae rehabilitation | |
| CN102266438B (en) | Antiviral agent for freshwater fishes | |
| CN108434422A (en) | Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease | |
| CN101332254B (en) | A traditional Chinese medicine composition for preventing and treating poultry respiratory diseases | |
| CN108379429A (en) | Chinese medicine composition and preparation method thereof for treating trigeminal neuralgia | |
| CN103784904A (en) | Traditional Chinese medicine oral liquid for treating poultry common cold due to wind-cold and preparation method thereof | |
| CN107496578A (en) | Treat Chinese medicine composition of chronic cough and asthma and preparation method and application | |
| CN108421002A (en) | Chinese medicine composition and preparation method thereof for treating nervous headache | |
| CN108057110A (en) | Chinese medicine composition for treating fatty liver and preparation method thereof | |
| CN108339094A (en) | Chinese medicine composition and preparation method thereof for treating coronary heart disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180731 |