CN113840912A - 包含识别分子的工程化免疫细胞 - Google Patents

包含识别分子的工程化免疫细胞 Download PDF

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Publication number
CN113840912A
CN113840912A CN202080036374.2A CN202080036374A CN113840912A CN 113840912 A CN113840912 A CN 113840912A CN 202080036374 A CN202080036374 A CN 202080036374A CN 113840912 A CN113840912 A CN 113840912A
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cell
domain
engineered immune
immune cell
binding moiety
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Chinese (zh)
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曾明
陈丽丽
刘勋
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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CN202080036374.2A 2019-05-16 2020-05-15 包含识别分子的工程化免疫细胞 Pending CN113840912A (zh)

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CN2019087260 2019-05-16
CNPCT/CN2019/087260 2019-05-16
PCT/CN2020/090601 WO2020228825A1 (en) 2019-05-16 2020-05-15 Engineered immune cells comprsing a recognition molecule

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CN202080036374.2A Pending CN113840912A (zh) 2019-05-16 2020-05-15 包含识别分子的工程化免疫细胞
CN202410461081.9A Withdrawn CN118420762A (zh) 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体
CN202080036396.9A Pending CN113825766A (zh) 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体

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CN202080036396.9A Pending CN113825766A (zh) 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体

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US (2) US20220241330A1 (enExample)
EP (2) EP3969572A4 (enExample)
JP (2) JP2022533621A (enExample)
KR (2) KR20220009966A (enExample)
CN (3) CN113840912A (enExample)
AU (2) AU2020275049A1 (enExample)
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CN115819622A (zh) * 2022-09-26 2023-03-21 湖南省人民医院(湖南师范大学附属第一医院) 针对b系白血病或淋巴瘤的双靶点car结构及药物组合物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7711945B2 (ja) 2019-04-30 2025-07-23 センティ バイオサイエンシズ インコーポレイテッド キメラ受容体及びその使用方法
US20240050474A1 (en) * 2021-02-09 2024-02-15 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
GB202105682D0 (en) * 2021-04-21 2021-06-02 Imp College Innovations Ltd Chimeric antigen receptor (CAR)-T cells
GB202105684D0 (en) * 2021-04-21 2021-06-02 Imperial College Innovations Ltd Chimeric antigen receptor (CAR)-T cells
EP4381081A1 (en) 2021-08-04 2024-06-12 Sana Biotechnology, Inc. Use of cd4-targeted viral vectors
WO2023114949A1 (en) 2021-12-16 2023-06-22 Sana Biotechnology, Inc. Methods and systems of particle production
US20250082777A1 (en) 2022-01-10 2025-03-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023150647A1 (en) 2022-02-02 2023-08-10 Sana Biotechnology, Inc. Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
US20260027145A1 (en) 2022-07-27 2026-01-29 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
WO2024044655A1 (en) 2022-08-24 2024-02-29 Sana Biotechnology, Inc. Delivery of heterologous proteins
EP4590688A1 (en) 2022-09-21 2025-07-30 Sana Biotechnology, Inc. Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
CN116836284A (zh) * 2023-04-21 2023-10-03 浙江正熙生物技术有限公司 一种抗人cd4抗体及其制备方法和应用
AU2024274792A1 (en) 2023-05-23 2025-10-23 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
WO2025068899A1 (en) * 2023-09-25 2025-04-03 Janssen Biotech, Inc. Compositions and methods for the generation of engineered, and or engineerable, cells
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
WO2026032970A1 (en) 2024-08-07 2026-02-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Cd4-specific chimeric antigen receptor and methods and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104822705A (zh) * 2012-10-24 2015-08-05 美国卫生和人力服务部 M971嵌合抗原受体
CN107708741A (zh) * 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
CN107849140A (zh) * 2015-07-16 2018-03-27 Ucb生物制药私人有限公司 结合cd22的抗体分子
CN107964549A (zh) * 2016-10-20 2018-04-27 上海恒润达生生物科技有限公司 靶向cd22的嵌合抗原受体及其用途
CN108350058A (zh) * 2015-04-08 2018-07-31 诺华股份有限公司 Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ594784A (en) * 2005-08-18 2013-06-28 Genmab As Therapy with CD4 binding peptides and radiation
EP2814846B1 (en) * 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
US10577417B2 (en) * 2014-09-17 2020-03-03 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
HRP20240357T1 (hr) * 2014-12-24 2024-06-07 Autolus Limited Stanica
CA2977106A1 (en) * 2015-02-27 2016-09-01 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
WO2017177175A1 (en) * 2016-04-07 2017-10-12 The George Washington University Methods and compositions targeting retroviral latency
AU2017312887A1 (en) * 2016-08-13 2019-03-07 United BioPharma, Inc. Treatment and sustained virologic remission of hiv infection by antibodies to cd4 in haart stabilized patients
CN117298260A (zh) * 2016-09-02 2023-12-29 莱蒂恩技术公司 用DuoCAR治疗癌症的组合物和方法
WO2019020733A1 (en) * 2017-07-26 2019-01-31 Cellectis METHODS OF IMMUNE CELL SELECTION OF THE ANTIGEN-DEPENDENT CHIMERIC ANTIGENIC RECEPTOR (CAR)
KR20210031898A (ko) * 2018-07-13 2021-03-23 난징 레전드 바이오테크 씨오., 엘티디. 전염병을 치료하기 위한 공동수용체 시스템

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104822705A (zh) * 2012-10-24 2015-08-05 美国卫生和人力服务部 M971嵌合抗原受体
CN108350058A (zh) * 2015-04-08 2018-07-31 诺华股份有限公司 Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法
CN107708741A (zh) * 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
CN107849140A (zh) * 2015-07-16 2018-03-27 Ucb生物制药私人有限公司 结合cd22的抗体分子
CN107964549A (zh) * 2016-10-20 2018-04-27 上海恒润达生生物科技有限公司 靶向cd22的嵌合抗原受体及其用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115819622A (zh) * 2022-09-26 2023-03-21 湖南省人民医院(湖南师范大学附属第一医院) 针对b系白血病或淋巴瘤的双靶点car结构及药物组合物

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