CN113827643A - Self-heating type collateral-dredging pain-relieving patch and preparation method thereof - Google Patents

Self-heating type collateral-dredging pain-relieving patch and preparation method thereof Download PDF

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Publication number
CN113827643A
CN113827643A CN202111213784.2A CN202111213784A CN113827643A CN 113827643 A CN113827643 A CN 113827643A CN 202111213784 A CN202111213784 A CN 202111213784A CN 113827643 A CN113827643 A CN 113827643A
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China
Prior art keywords
layer
medicine
patch
pain
self
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Inventor
周泽琴
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Shenzhen Integrated Traditional Chinese And Western Medicine Hospital
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Shenzhen Integrated Traditional Chinese And Western Medicine Hospital
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Priority to CN202111213784.2A priority Critical patent/CN113827643A/en
Publication of CN113827643A publication Critical patent/CN113827643A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254Acanthopanax or Eleutherococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/754Evodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention relates to the technical field of collateral-dredging and pain-relieving patches, in particular to a self-heating collateral-dredging and pain-relieving patch and a preparation method thereof. It comprises a medicine layer, a medical air-permeable adhesive layer and a thermal patch device layer; the medicine layer and the heating power patch device layer are respectively adhered to two sides of the medical air-permeable adhesive layer at opposite positions. The invention uses corydalis tuber, evodia rutaecarpa, cassia twig, achyranthes, notopterygium root, pubescent angelica root, slenderstyle acanthopanax bark and safflower as raw materials, pre-extracts effective components in the concentrated raw materials, replaces the traditional mode of directly pulverizing raw medicinal materials and bagging, and has high concentration of the effective components and strong medicinal effect. The heating power paster device layer is introduced to replace the traditional steam or microwave oven heating mode, so that the operation is more convenient, and the use comfort is higher. The medicine is absorbed by skin, local blood capillary is dilated, blood circulation is accelerated, metabolism is enhanced, inflammation and absorption of blood stasis are promoted by combining the common stimulation of heat and the medicine, and the heat not only assists the absorption of the medicine, but also has the effects of warming and activating channels, relieving swelling and pain, and clearing damp and dispelling cold.

Description

Self-heating type collateral-dredging pain-relieving patch and preparation method thereof
Technical Field
The invention relates to the technical field of collateral-dredging and pain-relieving patches, in particular to a self-heating collateral-dredging and pain-relieving patch and a preparation method thereof.
Background
The traditional Chinese medicine foment package is also called traditional Chinese medicine fomentation method, has been in more than 2000 years from now, is a non-invasive external treatment method adopting traditional Chinese medicine fomentation combined with acupoint stimulation, absorbs the advantages of traditional Chinese medicine treatment and acupoint stimulation, and completely avoids adverse reaction of gastrointestinal stimulation of oral medicines. The hot vapor of the foment bag expands local blood capillaries, accelerates blood circulation, enhances metabolism, promotes inflammation and blood stasis absorption, and achieves the purposes of warming and activating meridians, relaxing tendons and activating collaterals, regulating qi and blood, relieving swelling and pain, and eliminating dampness and dispelling cold by utilizing the warm heat.
The prior art scheme is as follows: the current methods of fomenting bags commonly used in clinic can be roughly divided into dry fomentation and wet fomentation. The dry hot compress is to wrap the Chinese medicinal powder into a cotton gauze bag, heat with a microwave oven, air to a suitable temperature, wrap the cotton gauze bag in a towel, and apply the medicated bag; the wet and hot compress is usually to put the Chinese traditional medicine into a decocting pan to decoct and keep the temperature, then to soak the liquid medicine with a towel, to wring out, to dry to the proper temperature, to carry out the external application, the treatment temperature is usually kept at about 50 ℃, and the patient's skin is flushed and comfortable. Although the application prospect of the traditional Chinese medicine external treatment method including the traditional Chinese medicine fomenting bag is ideal, the application range is still relatively limited at present. There are mainly the following problems: firstly, the medicinal materials are directly pulverized and bagged (as shown in figure 1), the effective components are difficult to completely seep out, so that the medicinal materials are wasted, and the medication effect is difficult to ensure; secondly, the heating time is short, and the medicine is changed frequently in clinic; thirdly, the treatment process requires the patient to rest in bed (as shown in figure 2), the treatment is inconvenient, and the patient has poor matching degree.
Disclosure of Invention
Aiming at the problems in the background technology, a self-heating type collateral-dredging and pain-relieving patch and a preparation method thereof are provided. The invention uses corydalis tuber, evodia rutaecarpa, cassia twig, achyranthes, notopterygium root, pubescent angelica root, slenderstyle acanthopanax bark and safflower as raw materials, pre-extracts effective components in the concentrated raw materials, replaces the traditional mode of directly pulverizing raw medicinal materials and bagging, and has the advantages of high concentration of the effective components, strong medicinal effect and good effect of dredging collaterals and relieving pain. The thin and long-lasting thermal patch device layer with heat storage is introduced to replace the traditional steam or microwave oven heating mode, so that the operation is more convenient, and the use comfort is higher. The medicine is absorbed by skin, local blood capillary is dilated, blood circulation is accelerated, metabolism is enhanced, inflammation and absorption of blood stasis are promoted by combining the common stimulation of heat and the medicine, and the heat not only assists the absorption of the medicine, but also has the effects of warming and activating channels, relieving swelling and pain, and clearing damp and dispelling cold.
The invention provides a self-heating type collateral-dredging and pain-relieving patch, which comprises a medicine layer, a medical breathable adhesive layer and a thermal patch device layer; the medicine layer and the heating power paster device layer are respectively pasted on two sides of the medical air-permeable pasting layer and are opposite in position; the heating power paster device layer comprises a back adhesive, a non-setting adhesive, a heating body, a breathable film and a non-woven fabric; one side of the back adhesive is adhered to the medical breathable adhesive layer; the other side of the gum, the non-setting adhesive, the heating body, the breathable film and the non-woven fabric are connected in sequence.
Preferably, the adhesive surface of the medical breathable adhesive layer is covered with a release film.
Preferably, the heating element is composed of iron powder, activated carbon, salt, vermiculite and resin.
Preferably, the medicinal layer is gauze with medicinal materials adsorbed thereon.
Preferably, the herbs include corydalis tuber, evodia rutaecarpa, cinnamomi ramulus, achyranthes bidentata, notopterygium root, pubescent angelica root, acanthopanax bark and safflower.
The invention also provides a preparation method of the self-heating type collateral-dredging and pain-relieving patch, which comprises the following steps:
s1, crushing medicinal materials of the collateral-dredging and pain-relieving formula (consisting of 10g of rhizoma corydalis, 10g of fructus evodiae, 20g of cassia twig, 20g of radix achyranthis bidentatae, 10g of notopterygium root, 10g of radix angelicae pubescentis, 20g of cortex acanthopanacis and 20g of safflower), sieving by a 60-mesh sieve, extracting for 2 times by using 60% ethanol, concentrating the extracting solution to 0.5g/ml, absorbing by medical gauze, drying, and preparing into a medicine layer;
s2, tearing off the release film, sticking the medicine layer on the medical air-permeable adhesive layer, and sticking the medical air-permeable adhesive layer on the acupuncture point or focus to be treated;
and S3, adhering the thermal patch device layer to the medical breathable adhesive layer.
Compared with the prior art, the invention has the following beneficial technical effects:
firstly, the invention adopts the modes of traditional Chinese medicine pre-extraction, concentration and drying, which not only solves the problems of the fomenting package dry-hot-compress method: the medicinal materials are directly pulverized into powder and bagged, so that the problem that the effective components are difficult to completely seep out is solved: the medicine decoction is directly dipped, the medicine carrying amount is small, and the residual medicine liquid can not be reused, thereby causing the problem of medicine waste.
The invention utilizes the existing heating patch device to heat continuously for 10 hours at constant temperature, has mature process, low price, convenience and easy obtainment and solves the problems of frequent clinical medicine change and short heating time.
The patch type traditional Chinese medicine patch is light, thin and easy to carry, is convenient for patients to operate, has high treatment matching degree, and solves the problem that the patients need to rest in bed in the traditional treatment process.
Drawings
FIG. 1 is a schematic structural diagram of an embodiment of the present invention;
FIG. 2 is a state diagram illustrating the use of one embodiment of the present invention;
FIG. 3 is a cross-sectional view of FIG. 2;
fig. 4 is a partially enlarged view of a portion a in fig. 3.
Reference numerals: 1. a drug layer; 2. a medical breathable adhesive layer; 3. a thermal patch device layer; 4. carrying out gum application; 5. adhesive sticker; 6. a heating element; 7. a gas permeable membrane; 8. non-woven fabrics; 9. and (4) a release film.
Detailed Description
Example one
As shown in fig. 1-4, the self-heating type collateral-dredging and pain-relieving patch provided by the invention comprises a medicine layer 1, a medical breathable adhesive layer 2 and a thermal patch device layer 3; the medicine layer 1 and the heating power paster device layer 3 are respectively pasted on two sides of the medical air-permeable pasting layer 2 and are opposite in position; the thermal patch device layer 3 comprises a back adhesive 4, a non-setting adhesive 5, a heating body 6, a breathable film 7 and a non-woven fabric 8; one side of the back adhesive 4 is adhered to the medical breathable adhesive layer 2; the other side of the back adhesive 4, the non-setting adhesive 5, the heating body 6, the breathable film 7 and the non-woven fabric 8 are connected in sequence.
Furthermore, a release film 9 is covered on the pasting surface of the medical breathable pasting layer 2.
Further, the heating element 6 is composed of iron powder, activated carbon, salt, vermiculite and resin, and releases heat by iron oxidation reaction. Meanwhile, the strong adsorbability of the activated carbon is utilized, water vapor is stored in a loose structure of the activated carbon, and is gasified into water drops, flows out to contact with air and iron powder, and rapidly reacts under the catalytic action of sodium chloride to generate ferric hydroxide and release heat. The mineral material vermiculite has the heat preservation effect and can generate heat for a long time.
Further, the medicine layer 1 is gauze with adsorbed medicinal materials.
Further, the medicinal materials include rhizoma corydalis, fructus evodiae, ramulus Cinnamomi, Achyranthis radix, Notopterygii rhizoma, radix Angelicae Pubescentis, cortex Acanthopanacis and Carthami flos.
Example two
The invention also provides a preparation method of the self-heating type collateral-dredging and pain-relieving patch, which comprises the following steps:
s1, crushing medicinal materials of the collateral-dredging and pain-relieving formula (consisting of 10g of rhizoma corydalis, 10g of fructus evodiae, 20g of cassia twig, 20g of radix achyranthis bidentatae, 10g of notopterygium root, 10g of radix angelicae pubescentis, 20g of cortex acanthopanacis and 20g of safflower), sieving with a 60-mesh sieve, extracting with 60% ethanol for 2 times, concentrating the extracting solution to 0.5g/ml, absorbing with medical gauze, drying, and preparing into a medicine layer 1;
s2, tearing off the release film 9, sticking the medicine layer 1 on the medical air-permeable adhesive layer 2, and sticking the medical air-permeable adhesive layer on the acupuncture point or focus;
and S3, adhering the thermal patch device layer 3 to the medical breathable adhesive layer 2.
The invention uses corydalis tuber, evodia rutaecarpa, cassia twig, achyranthes, notopterygium root, pubescent angelica root, slenderstyle acanthopanax bark and safflower as raw materials, pre-extracts effective components in the concentrated raw materials, replaces the traditional mode of directly pulverizing raw medicinal materials and bagging, and has the advantages of high concentration of the effective components, strong medicinal effect and good effect of dredging collaterals and relieving pain. The thin and light heating power surface mounting device layer 3 with long-lasting heat storage is introduced to replace the traditional steam or microwave oven heating mode, so that the operation is more convenient, and the use comfort is higher. The medicine is absorbed by skin, local blood capillary is dilated, blood circulation is accelerated, metabolism is enhanced, inflammation and absorption of blood stasis are promoted by combining the common stimulation of heat and the medicine, and the heat not only assists the absorption of the medicine, but also has the effects of warming and activating channels, relieving swelling and pain, and clearing damp and dispelling cold.
The embodiments of the present invention have been described in detail with reference to the drawings, but the present invention is not limited thereto, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention.

Claims (6)

1. A self-heating type patch for dredging collaterals and relieving pain is characterized by comprising a medicine layer (1), a medical breathable adhesive layer (2) and a thermal patch device layer (3); the medicine layer (1) and the thermal patch device layer (3) are respectively stuck on two sides of the medical air-permeable adhesive layer (2) and are opposite in position;
the heating power patch device layer (3) comprises a back adhesive (4), a non-setting adhesive (5), a heating body (6), a breathable film (7) and a non-woven fabric (8); one side of the back adhesive (4) is adhered to the medical breathable adhesive layer (2); the other side of the back adhesive (4), the self-adhesive (5), the heating body (6), the breathable film (7) and the non-woven fabric (8) are connected in sequence.
2. The self-heating type patch for removing obstruction in channels to relieve pain of claim 1, wherein the release film (9) is coated on the adhesive surface of the medical breathable adhesive layer (2).
3. The self-heating type patch for removing obstruction in channels to relieve pain according to claim 1, wherein the heating element (6) is composed of iron powder, activated carbon, salt, vermiculite and resin.
4. The self-heating type patch for removing obstruction in channels to relieve pain of claim 1, wherein the drug layer (1) is gauze with adsorbed drugs.
5. The self-heating type collaterals-dredging and pain-relieving patch as claimed in claim 1, wherein the medicinal materials comprise corydalis tuber, evodia rutaecarpa, cassia twig, achyranthes bidentata, notopterygium root, pubescent angelica root, acanthopanax bark and safflower.
6. A preparation method of an auto-thermal type collateral-dredging and pain-relieving patch is characterized by comprising the following steps:
s1, crushing the medicinal materials of corydalis tuber 10g, evodia rutaecarpa 10g, cassia twig 20g, achyranthes bidentata 20g, notopterygium root 10g, pubescent angelica root 10g, acanthopanax bark 20g and safflower 20g, sieving by a 60-mesh sieve, extracting for 2 times by using 60% ethanol, concentrating the extracting solution to 0.5g/ml, absorbing by medical gauze, drying, and preparing into a medicine layer (1);
s2, tearing off the release film (9), adhering the medicine layer (1) on the medical air-permeable adhesive layer (2), and adhering the medicine layer on the treatment acupuncture point or focus;
s3, adhering the thermal patch device layer (3) to the medical air-permeable adhesive layer (2).
CN202111213784.2A 2021-10-19 2021-10-19 Self-heating type collateral-dredging pain-relieving patch and preparation method thereof Pending CN113827643A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115040524A (en) * 2022-07-27 2022-09-13 深圳市中西医结合医院 Use of 4-cholesten-3-ones for the treatment of multiple myeloma bone disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103271997A (en) * 2013-05-22 2013-09-04 湖北金鹰生物科技有限公司 Thermomagnetic treating plaster with functions of warming, activating meridian, promoting blood circulation and stopping pain
CN105031509A (en) * 2015-06-19 2015-11-11 广西信业生物技术有限公司 Self-heating medical hot-compression patch for rheumatic pain and method for manufacturing self-heating medical hot-compression patch
CN210355064U (en) * 2017-11-08 2020-04-21 武汉紫杉红技术开发有限公司 Self-heating medicine storage plaster
CN112587564A (en) * 2021-01-06 2021-04-02 张沧良 Self-heating medicinal plaster

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103271997A (en) * 2013-05-22 2013-09-04 湖北金鹰生物科技有限公司 Thermomagnetic treating plaster with functions of warming, activating meridian, promoting blood circulation and stopping pain
CN105031509A (en) * 2015-06-19 2015-11-11 广西信业生物技术有限公司 Self-heating medical hot-compression patch for rheumatic pain and method for manufacturing self-heating medical hot-compression patch
CN210355064U (en) * 2017-11-08 2020-04-21 武汉紫杉红技术开发有限公司 Self-heating medicine storage plaster
CN112587564A (en) * 2021-01-06 2021-04-02 张沧良 Self-heating medicinal plaster

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115040524A (en) * 2022-07-27 2022-09-13 深圳市中西医结合医院 Use of 4-cholesten-3-ones for the treatment of multiple myeloma bone disease

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Application publication date: 20211224

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