CN110201038B - Wound-treating pain-relieving plaster - Google Patents
Wound-treating pain-relieving plaster Download PDFInfo
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Abstract
A plaster for treating injuries and relieving pain belongs to the technical field of medicines. The heat-insulation core-applying paper comprises a core-applying back lining layer, a magnetic glue layer, a heating layer, a silica gel layer, a medicine glue layer and release paper which are sequentially arranged from bottom to top, wherein the magnetic glue layer is formed by uniformly mixing and coating nano neodymium-iron-boron magnetic powder, carboxymethyl chitosan glue paste, polyvinyl alcohol glue paste and glycerol on the core-applying back lining layer and then drying at a low temperature; the heating layer is formed by pressing and mixing iron powder, activated carbon, sodium chloride, super absorbent resin, sodium polyacrylate mucilage, polyvinyl alcohol mucilage and polystyrene particles on a magnetic glue layer; the silicone gel layer adopts a medical silicone gel dressing film; the medicinal glue layer is prepared by uniformly mixing Chinese medicinal extract, glycerol, carboxymethyl chitosan glue and polyvinyl alcohol glue, coating on release paper, drying at low temperature, and adhering to the silica gel layer. The traditional thermotherapy, the magnetic field therapy and the traditional Chinese medicine cataplasm are organically combined, the transdermal absorption of the medicine is promoted by magnetic-thermal synergy, and the magnetic effect and the thermal effect have the characteristics of controllability, sustainability and stability.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a plaster for treating injuries and relieving pain.
Background
Pain is one of the most common symptoms in clinic, and is brought into the category of pain syndrome in traditional Chinese medicine. The causes of pain are complex, and cold and heat exogenous pathogens, traumatic injuries, contusion, emotional injuries and overexertion are all the causes of pain. The pathogenesis of the pain is classified into excess pain and deficiency pain according to deficiency and excess, and the excess pain is caused by the obstruction of meridians and collaterals due to the unsmooth qi and blood caused by cold invasion into the body; deficiency pain is caused by qi and blood stagnation and malnutrition of the zang-fu organs and meridians. The traditional Chinese medicine adopts acupuncture, massage, fumigation, hot ironing, application, plaster, magnetic therapy and other means to dredge channels and collaterals, remove cold and dampness, promote qi and blood circulation, tonify qi and enrich blood, achieve the effects of 'dredging channels and not causing pain, and nourishing blood', and promote the body to recover the normal physiological state of 'the circulation of meridians is not continuous and the surrounding is not easy'.
The Chinese iris-people's secret recipe for treating injuries and teasel roots by virtue of the immortal professor is the earliest monograph in orthopedics and traumatology in China, and the experience of internal and external application of the Chinese iris-carried syndrome differentiation and injury treatment becomes a regular script for later-life syndrome differentiation, establishment of law, prescription and application of medicine. The treatment principle of the rush is that the treatment principle of treating wind first and self-extinguishing blood-flowing wind is included, and the formula is used for tonifying liver and kidney, promoting blood circulation and replenishing blood and dispelling wind and eliminating dampness. The pain relieving pill recorded by the secret recipe is composed of radix aconiti preparata, radix clematidis, fried szechwan chinaberry fruit (also named jinlingzi) and star anise, has little medicine, has the effects of dredging channels and collaterals, dispelling wind and removing dampness, promoting qi and blood circulation and warming channels to relieve pain, is a secret recipe Yunling pain relieving pill, and is used for treating primary injury and lumbar pain, and does not ask men, women, virgin and old children for all, and is mainly used for treating blood-qi stagnation and foot and waist pain in the formula Yun in the formula of Yongzhi formula.
The external treatment of traditional Chinese medicine has the characteristics of simplicity, convenience, cheapness and verification, and compared with the internal treatment, the external treatment of traditional Chinese medicine has the wonderful effect of 'returning from different ways and working differently'. The heat treatment and the magnetic therapy have the effects of dredging the channels and regulating the blood and qi, cause a series of changes of the nerve and the body fluid metabolism of a human body and promote the absorption and the synergism of the medicine, and have a long history for treating related diseases. For example, in the book of Ling Shu, shou Fu Ling and Fu Ling, there is a record of using cotton cloth to soak medicated wine and apply it for treating arthralgia due to cold, and in the book of Shi Ji: ' Yu Shi Jia Shi Ying, Shi Qiao and kang du Zhu Zheng when ancient times. The application of magnetic therapy is also recorded in ancient books, for example, the records of Shen nong's herbal classic: the main indications of magnetite are periarthralgia and rheumatism, swelling and pain of limbs and joints, unrelieved substance, washing and acid washing Xie, removing intense heat and restlessness and deafness, all of which are the most common in modern magnetic acupoint application, the magnetite is placed on the affected part to treat diseases in Qian jin Yao Fang and Ben Cao gang mu. Relevant documents believe that the optimal heat treatment temperature of a human body is 50 +/-5 ℃, traditional Chinese medicine hot compress is carried out within the temperature range of 50-60 ℃, the local blood circulation can be increased, the drug effect is improved, the hot compress treatment time is about 4 hours, and the low-temperature burn condition is avoided. The magnetic therapy effect is that the strength is too strong or too weak, which can cause potential harm to human body, and the strength, time and course of treatment need to be determined according to the condition of the patient.
The Chinese medicine cataplasm has all the features of transdermal medicine feeding system and may be used widely in treating various kinds of closed traumatic diseases. However, the existing preparation does not organically combine the traditional Chinese medicine cataplasm, the thermotherapy and the magnetic field therapy together, and the medicine can not completely play the treatment effects of dredging channels and collaterals, dispelling wind and removing dampness, and promoting qi circulation and relieving pain, especially aiming at pain caused by deficiency cold, strain and falling and sudden contusion due to cold invasion to the body and blood and qi stagnation, such as closed soft tissue injury, lumbar muscle strain, joint sprain, scapulohumeral periarthritis, carpal tunnel syndrome, lumbocrural pain and other pain diseases, and the effects of 'no pain in dredging and tenderness in honor' can not be achieved.
Disclosure of Invention
The invention mainly solves the technical problems of the prior preparation and provides a wound-treating and pain-relieving plaster which is characterized in that the plaster is organically combined with the thermotherapy and the magnetic therapy by focusing on the syndrome differentiation prescription of 'rush' and the experience of internal and external application and utilizing the characteristics of thermotherapy and magnetotherapy, so that the medicine plays the treatment roles of dredging channels and collaterals, dispelling wind and removing dampness, and promoting qi circulation and relieving pain under the continuous synergy of the magnetic stimulation and the thermotherapy.
The technical problem of the invention is mainly solved by the following technical scheme: a wound-treating pain-relieving plaster comprises a core-applying back lining layer, a magnetic adhesive layer, a heating layer, a silica gel layer, a medicinal adhesive layer and release paper which are sequentially arranged from bottom to top, wherein the magnetic adhesive layer is formed by uniformly coating nano neodymium-iron-boron magnetic powder, carboxymethyl chitosan adhesive cement, polyvinyl alcohol adhesive cement and glycerol on the core-applying back lining layer and then drying at a low temperature; the heating layer is formed by uniformly mixing iron powder, activated carbon, sodium chloride, super absorbent resin, sodium polyacrylate mucilage, polyvinyl alcohol mucilage and polystyrene particles and pressing the mixture on a magnetic adhesive layer; the silicone gel layer is a medical silicone gel dressing film and is stuck to the heating layer; the medicinal glue layer is formed by uniformly mixing a traditional Chinese medicine extract, glycerin, carboxymethyl chitosan glue paste and polyvinyl alcohol glue paste, coating the mixture on release paper, drying the mixture at low temperature, and then pasting the mixture with a silica gel layer, wherein the traditional Chinese medicine extract is composed of extract powder, star anise powder and star anise oil.
Preferably, the prescription of the traditional Chinese medicine extract is as follows: 5g of clematis root, 10g of fried szechwan chinaberry fruit, 10g of prepared common monkshood mother root and 10g of star anise.
Preferably, the preparation of the traditional Chinese medicine extract comprises the following steps:
(1) preparing extract powder: pulverizing radix Clematidis, parched fructus Toosendan and radix Aconiti Preparata into coarse powder, placing into an extractor, adding 3-4 times of 70% ethanol according to weight, heating and reflux extracting at 75-85 deg.C for 2-3 hr; separating residue and liquid after reflux extraction, and filtering; concentrating the filtrate under reduced pressure to obtain soft extract, oven drying at 60 deg.C to obtain extract, and pulverizing the extract into fine powder to obtain extract powder 3.0-4.0 g;
(2) preparing star anise powder: taking 1.5-2.5g of star anise and crushing the star anise into fine powder;
(3) preparing star anise oil: taking 7.5-8.5g of star anise, crushing the star anise into coarse powder, putting the coarse powder into an extractor, adding 3-4 times of purified water according to the weight of the star anise, soaking for 1 hour, performing steam distillation extraction for 4-5 hours, and collecting 0.4-0.6g of star anise oil.
Preferably, the magnetic adhesive layer is prepared by the following steps: mixing 2.0-3.0g carboxymethyl chitosan mucilage, 4.5-5.5g polyvinyl alcohol mucilage, 0.3-0.5g glycerin, 2.2-2.8g nanometer neodymium iron boron magnetic powder, stirring, uniformly coating on the back lining layer of the core, forming an oval shape, and drying at the low temperature of 60 ℃.
Preferably, the heat generating layer is prepared by the following steps: 1.5-2.0g of super absorbent resin, 2.0-2.4g of activated carbon, 0.2-0.4g of sodium chloride, 0.12-0.18g of polystyrene particles, 5.0-6.0g of iron powder, 4.5-5.5g of sodium polyacrylate mucilage and 1.8-2.2g of polyvinyl alcohol mucilage are uniformly mixed, pressed into an oval thin layer on a magnetic glue layer, and then a silica gel layer is stuck on a heating layer.
Preferably, the formulation of the medicated glue layer is as follows: mixing 1.5-2.5g fructus Anisi Stellati powder, 3.0-4.0g extract powder, 0.4-0.6g oleum Anisi Stellati, 0.5-0.7g glycerol, 3.5-4.5g carboxymethyl chitosan mucilage, and 7.0-8.0 g polyvinyl alcohol mucilage, coating on release paper to form ellipse, drying at 60 deg.C, and sticking the medicinal colloid layer on the silica gel layer.
Preferably, the silicone gel dressing film is a soft and transparent wound contact layer dressing, is mainly used for nursing various exudation type wounds, such as operation incisions, surgical wounds, second-degree burns, diabetic feet and the like, is formed by punching a TPU film and a soft silicone gel base coating composite curing machine, the upper surface and the lower surface of the TPU film are protected by CCK gummed paper, and the CCK gummed paper needs to be removed when the dressing film is used.
Preferably, the carboxymethyl chitosan mucilage is prepared by the following steps: dispersing carboxymethyl chitosan in proper amount of purified water, swelling and suspending, dissolving in water bath at 60-70 deg.c, adding purified water to full amount, and stirring to form 5% concentration gelatin slurry.
Preferably, the sodium polyacrylate mucilage is prepared by the following steps: dispersing sodium polyacrylate in purified water, stirring for 20min, swelling, standing for several hours to dissolve completely, adding purified water to full volume, and stirring to obtain 1% gelatin slurry.
Preferably, the polyvinyl alcohol mucilage is prepared by the following steps: dispersing a specified amount of polyvinyl alcohol in a proper amount of purified water, and then placing the mixture on a water bath at 60-70 ℃ to dissolve the mixture into 8% of mucilage, wherein the polyvinyl alcohol is PVA 1788.
Preferably, the iron powder is 200 meshes, and the content is more than or equal to 98 percent.
Preferably, the pain relieving plaster for physical injury is packaged in an aluminum plastic bag, vacuumized, magnetized in an external magnetic field with the magnetic strength of 0.1-1T, and magnetized with the magnetic induction intensity of 0.05-0.1T.
The invention has the following beneficial effects:
1. on the basis of digging pain relieving pills for treating the lumbago from 'Xian Zhi Shang Duan secret recipe', the invention develops a new, scientifically optimized and developed pain relieving plaster for treating the waist pain from an ancient recipe under the guidance of the holistic concept and the syndrome differentiation and treatment concept of the traditional Chinese medicine, the efficacy of the plaster directly reaches the focus of infection, the plaster is good in adaptability and safe to use, and the medication compliance of patients is enhanced. The traditional thermotherapy, the magnetic field therapy and the traditional Chinese medicine cataplasm are organically combined, the transdermal absorption of the medicine is promoted by magnetic-thermal synergy, and the magnetic effect and the thermal effect have the characteristics of controllability, sustainability and stability.
2. According to the invention, the medicinal gel layer is isolated from the heating layer through the silica gel layer, the skin and the medicine are not in direct contact with the heating layer, the heat generated by the heating layer can be transferred to the medicinal gel layer and the affected part through the silica gel layer, the medicine is continuously heated and permeates the affected part effectively, and the dual functions of thermal therapy and medicinal therapy are achieved.
3. In the invention, the magnetic adhesive layer is prepared by using the bad air property of the carboxymethyl chitosan adhesive cement and the polyvinyl alcohol adhesive cement after film forming, so that the air permeability of the magnetic adhesive layer is reduced, and the speed of air entering the heating layer is controlled.
4. In the invention, the super-strong water absorption performance of the super-absorbent resin is utilized, and the sodium polyacrylate mucilage, the polyvinyl alcohol mucilage and the polystyrene particles are introduced, so that the super-absorbent resin can be pressed into kneaded conglobation, loose and thin slices rich in gaps when being contacted, and the gaps can absorb air to enable the heating reaction to be continuously carried out.
5. In the invention, the silicone gel layer adopts a medical silicone gel dressing film, the silicone gel dressing film has an open mesh structure, stable temperature change and good adhesion to dry skin and non-woven fabric, and can be seamlessly adhered to the body surface and be pasted on the skin surface for a long time.
6. In the invention, by introducing carboxymethyl chitosan mucilage and polyvinyl alcohol mucilage, the adhesive layer is soft, has excellent tensile strength and good antibacterial, bacteriostatic and breathable absorbability.
7. In the invention, the plaster is magnetized by being placed in an external magnetic field to show a magnetic effect.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present invention;
FIG. 2 is a schematic structural view of the release paper of the present invention;
FIG. 3 is a graph comparing the thermal effect curves of example 1, example 2 and example 3 of the present invention.
In the figure: 1. applying a core backing layer; 2. a magnetic glue layer; 3. a heat generating layer; 4. a layer of silicone gel; 5. a medicinal glue layer; 6. and (4) release paper.
Detailed Description
The technical scheme of the invention is further specifically described by the following embodiments and the accompanying drawings.
A plaster for treating wound and relieving pain, as shown in figure 1-figure 2, comprises a core backing layer, a magnetic adhesive layer, a heating layer, a silica gel layer, a medicinal adhesive layer and release paper, which are arranged from bottom to top in sequence, wherein the magnetic adhesive layer is prepared by uniformly coating nanometer neodymium iron boron magnetic powder, carboxymethyl chitosan adhesive paste, polyvinyl alcohol adhesive paste and glycerol on the core backing layer and drying at low temperature; the heating layer is formed by uniformly mixing and pressing iron powder, activated carbon, sodium chloride, super absorbent resin, sodium polyacrylate mucilage, polyvinyl alcohol mucilage and polystyrene particles on a magnetic adhesive layer, wherein the iron powder is 200 meshes, and the content of the iron powder is more than or equal to 98%; the silicone gel layer is a medical silicone gel dressing film and is stuck to the heating layer; the medicinal glue layer is formed by uniformly mixing and coating a traditional Chinese medicine extract, glycerol, carboxymethyl chitosan glue paste and polyvinyl alcohol glue paste on release paper, drying at low temperature and then pasting the mixture with a silica gel layer, wherein the traditional Chinese medicine extract is prepared from 5g of clematis root, 10g of fried szechwan chinaberry fruit, 10g of prepared common monkshood mother root and 10g of star anise.
The sodium polyacrylate is stable to temperature change, has the function of fixing metal ions, and can prevent the heating layer material from being inactivated in the storage process; the polyvinyl alcohol is easy to form a film and has good adhesive force, when the polyvinyl alcohol adopts PVA1788 and the concentration of the prepared aqueous solution is 8%, the viscosity is stable, but when the concentration exceeds 10%, the polyvinyl alcohol is easy to gel into jelly along with the time extension; the polystyrene particles are a light high polymer material, have the characteristics of hydrophobicity, heat preservation, stable chemical performance and the like, and can enlarge the gaps among the heating materials, avoid agglomeration and enable the heating materials to be in a loose state. The carboxymethyl chitosan has good moisture retention and film forming properties, and has antibacterial and bacteriostatic effects.
Example 1: taking 10g of star anise, wherein 2g of star anise is crushed into fine powder for later use, and the other 8g of star anise is crushed into coarse powder and placed in an extractor, adding 4 times of purified water according to the weight of the star anise for soaking for 1 hour, then carrying out steam distillation extraction for 5 hours, and collecting star anise oil for later use; crushing radix clematidis, fried szechwan chinaberry fruit and prepared monkshood into coarse powder, placing the coarse powder into an extractor, adding 4 times of 70% ethanol according to the weight of the coarse powder, heating and refluxing for extraction, wherein the refluxing extraction temperature is 75-85 ℃, the refluxing extraction time is 3 hours, separating residue liquid after the refluxing extraction is finished, filtering, concentrating filtrate under reduced pressure into thick paste, drying the thick paste at 60 ℃ to obtain extract, crushing the extract into fine powder to obtain 3.5g of extract powder for later use; dispersing a specified amount of sodium polyacrylate in a proper amount of purified water, stirring for 20min, standing for several hours after swelling and suspending until the sodium polyacrylate is completely dissolved, then adding the purified water to the full amount, and stirring uniformly to form sodium polyacrylate mucilage with the concentration of 1% for later use; dispersing carboxymethyl chitosan in proper amount in purified water, swelling and suspending, dissolving in water bath at 60-70 deg.c, adding purified water to full amount, and stirring to obtain 5% concentration carboxymethyl chitosan gel slurry; taking a specified amount of PVA1788 to be dispersed in a proper amount of purified water, and then placing the mixture on a water bath at 60-70 ℃ to be dissolved into polyvinyl alcohol mucilage with the concentration of 8% for later use.
Uniformly stirring 2.5g of carboxymethyl chitosan mucilage with the concentration of 5%, 5.0g of polyvinyl alcohol mucilage with the concentration of 8%, 0.4g of glycerin and 2.5g of nano neodymium iron boron magnetic powder, then uniformly coating an oval (10 cm x 8cm in size) water absorption surface of a core backing layer (12 cm x 10cm in size), and drying at the low temperature of 60 ℃ to prepare a magnetic glue layer; taking 1.75g of super absorbent resin, 2.2g of activated carbon, 0.3g of sodium chloride, 0.15g of polystyrene particles, 5.5g of iron powder, 5.0g of 1% sodium polyacrylate mucilage and 2.0g of 8% polyvinyl alcohol mucilage, mixing uniformly in sequence, quickly pressing the mixture on a magnetic glue layer to form an oval thin layer (the size is 9cm x 7.2cm), taking a silica gel coating film (the size is 12cm x 10cm), removing CCK (cubic boron-potassium) coating paper on one side of the silica gel coating film, and sticking one side of the CCK coating paper removed from the silica gel coating film to a heating layer for later use; mixing 2.0g of star anise powder, 3.5g of extract powder, 0.5g of star anise oil, 0.5g of glycerol, 4.0g of carboxymethyl chitosan mucilage with the concentration of 5% and 7.5g of polyvinyl alcohol mucilage with the concentration of 8%, coating an oval shape (the size is 10cm x 8cm) on release paper, and drying at low temperature of 60 ℃ to prepare a medicinal adhesive layer; removing CCK gummed paper on the other side of the silica gel dressing film, and sticking the CCK gummed paper and the medicinal glue layer to prepare a plaster; packaging the plaster in an aluminum plastic bag, rapidly vacuumizing, magnetizing in an external magnetic field with magnetic strength of 0.1-1T, and applying on the affected part after removing release paper for one day.
Example 2: taking 10g of star anise, wherein 2.5g of star anise is crushed into fine powder for later use, and the other 7.5g of star anise is crushed into coarse powder and placed in an extractor, adding 3 times of purified water according to the weight of the star anise for soaking for 1 hour, performing steam distillation for extraction for 4 hours, and collecting star anise oil for later use; crushing radix clematidis, fried szechwan chinaberry fruit and prepared monkshood into coarse powder, placing the coarse powder into an extractor, adding 70% ethanol which is 3 times of the weight of the coarse powder into the extractor for heating reflux extraction at the temperature of 75-85 ℃ for 3 hours, separating residue liquid after the reflux extraction is finished, filtering, concentrating the filtrate under reduced pressure into thick paste, drying the thick paste at the temperature of 60 ℃ to obtain extract, crushing the extract into fine powder to obtain 4.0g of extract powder for later use; dispersing a specified amount of sodium polyacrylate in a proper amount of purified water, stirring for 20min, standing for several hours after swelling and suspending until the sodium polyacrylate is completely dissolved, then adding the purified water to the full amount, and stirring uniformly to form sodium polyacrylate mucilage with the concentration of 1% for later use; dispersing carboxymethyl chitosan in proper amount in purified water, swelling and suspending, dissolving in water bath at 60-70 deg.c, adding purified water to full amount, and stirring to obtain 5% concentration carboxymethyl chitosan gel slurry; taking a specified amount of PVA1788 to be dispersed in a proper amount of purified water, and then placing the mixture on a water bath at 60-70 ℃ to be dissolved into polyvinyl alcohol mucilage with the concentration of 8% for later use.
Uniformly stirring 3.0g of carboxymethyl chitosan mucilage with the concentration of 5%, 5.5g of polyvinyl alcohol mucilage with the concentration of 8%, 0.5g of glycerin and 2.8g of nano neodymium iron boron magnetic powder, then uniformly coating an oval (10 cm x 8cm in size) water absorption surface of a core backing layer (12 cm x 10cm in size), and drying at the low temperature of 60 ℃ to prepare a magnetic glue layer; taking 2.0g of super absorbent resin, 2.4g of activated carbon, 0.4g of sodium chloride, 0.18g of polystyrene particles, 6.0g of iron powder, 5.5g of sodium polyacrylate mucilage with the concentration of 1% and 2.2g of polyvinyl alcohol mucilage with the concentration of 8%, mixing uniformly in sequence, quickly pressing the mixture on a magnetic glue layer to form an oval thin layer (the size is 9cm x 7.2cm), taking a silica gel coating film (the size is 12cm x 10cm), removing CCK (polyvinyl chloride) coated paper on one side of the silica gel coating film, removing one side of the CCK coated paper from the silica gel coating film, and adhering the side to a heating layer for later use; mixing 2.5g of star anise powder, 4.0g of extract powder, 0.4g of star anise oil, 0.5g of glycerol, 4.5g of carboxymethyl chitosan mucilage with the concentration of 5% and 8.0g of polyvinyl alcohol mucilage with the concentration of 8%, coating an oval shape (the size is 10cm x 8cm) on release paper, and drying at low temperature of 60 ℃ to prepare a medicinal adhesive layer; removing CCK gummed paper on the other side of the silica gel dressing film, and sticking the CCK gummed paper and the medicinal glue layer to prepare a plaster; packaging the plaster in an aluminum plastic bag, rapidly vacuumizing, magnetizing in an external magnetic field with magnetic strength of 0.1-1T, and applying on the affected part after removing release paper for one day.
Example 3: taking 10g of star anise, wherein 1.5g of star anise is crushed into fine powder for later use, and the other 8.5g of star anise is crushed into coarse powder and placed in an extractor, adding 4 times of purified water according to the weight of the star anise for soaking for 1 hour, performing steam distillation for extraction for 5 hours, and collecting star anise oil for later use; crushing radix clematidis, fried szechwan chinaberry fruit and prepared monkshood into coarse powder, placing the coarse powder into an extractor, adding 4 times of 70% ethanol according to the weight of the coarse powder, heating and refluxing for extraction, wherein the refluxing extraction temperature is 75-85 ℃, the refluxing extraction time is 3 hours, separating residue liquid after the refluxing extraction is finished, filtering, concentrating filtrate under reduced pressure into thick paste, drying the thick paste at 60 ℃ to obtain extract, crushing the extract into fine powder to obtain 3.0g of extract powder for later use; dispersing a specified amount of sodium polyacrylate in a proper amount of purified water, stirring for 20min, standing for several hours after swelling and suspending until the sodium polyacrylate is completely dissolved, then adding the purified water to the full amount, and stirring uniformly to form sodium polyacrylate mucilage with the concentration of 1% for later use; dispersing carboxymethyl chitosan in proper amount in purified water, swelling and suspending, dissolving in water bath at 60-70 deg.c, adding purified water to full amount, and stirring to obtain 5% concentration carboxymethyl chitosan gel slurry; taking a specified amount of PVA1788 to be dispersed in a proper amount of purified water, and then placing the mixture on a water bath at 60-70 ℃ to be dissolved into polyvinyl alcohol mucilage with the concentration of 8% for later use.
Uniformly stirring 2.0g of carboxymethyl chitosan mucilage with the concentration of 5%, 4.5g of polyvinyl alcohol mucilage with the concentration of 8%, 0.4g of glycerin and 2.2g of nano neodymium iron boron magnetic powder, then uniformly coating an oval (10 cm x 8cm in size) water absorption surface of a core backing layer (12 cm x 10cm in size), and drying at the low temperature of 60 ℃ to prepare a magnetic glue layer; taking 1.5g of super absorbent resin, 2.0g of activated carbon, 0.2g of sodium chloride, 0.12g of polystyrene particles, 5.0g of iron powder, 4.5g of sodium polyacrylate mucilage with the concentration of 1% and 1.8g of polyvinyl alcohol mucilage with the concentration of 8% to be mixed uniformly in sequence, quickly pressing the mixture on a magnetic glue layer to form an oval thin layer (the size is 9cm x 7.2cm), then taking a silica gel coating film (the size is 12cm x 10cm), removing CCK (Poly vinyl Ketone) coated paper on one side of the silica gel coating film, removing one side of the CCK coated paper from the silica gel coating film, and adhering the side to a heating layer for later use; mixing 1.5g of star anise powder, 3.0g of extract powder, 0.6g of star anise oil, 0.4g of glycerol, 3.5g of carboxymethyl chitosan mucilage with the concentration of 5% and 7.0g of polyvinyl alcohol mucilage with the concentration of 8%, coating an oval shape (the size is 10cm x 8cm) on release paper, and drying at low temperature of 60 ℃ to prepare a medicinal adhesive layer; removing CCK gummed paper on the other side of the silica gel dressing film, and sticking the CCK gummed paper and the medicinal glue layer to prepare a plaster; packaging the plaster in an aluminum plastic bag, rapidly vacuumizing, magnetizing in an external magnetic field with magnetic strength of 0.1-1T, and applying on the affected part after removing release paper for one day.
The thermal effect tests were performed on the plasters obtained in example 1, example 2 and example 3, the thermal effect being mainly produced by the microcell reaction of iron powder, activated carbon, sodium chloride in a humid environment.
The heat effect test is drawn up by referring to a [ heat effect ] detection method under Kanlisha item in the first part of China pharmacopoeia 2015 edition, the laboratory temperature is 20 +/-2 ℃, and the humidity is 45-65%; the experimental method comprises the following steps: taking the prepared plaster with the core backing layer facing upwards, covering with 6 layers of towels, removing the release paper, placing the medical adhesive layer facing downwards on the foam board with the thermocouple, connecting the thermocouple with a temperature recorder, setting recording parameters, collecting data and transmitting to a computer, recording the heat holding time (beginning when the temperature rises to 40 ℃ and ending when the temperature falls to 40 ℃), measuring the highest temperature, and analyzing the heat effect curve.
The test shows that the maximum temperature of the thermal effect of the embodiment 1 is 53.5 ℃, and the holding time is 4 h; the maximum temperature of the heat effect of the embodiment 2 is 57.5 ℃, and the heat holding time is 3.8 h; the maximum temperature of the heat effect of example 3 is 50.5 ℃, and the holding time is 4.3 h. The test values of example 1, example 2 and example 3 all correspond to the optimal thermotherapy temperature in humans. FIG. 3 is a graph comparing the thermal effect curves of example 1, example 2 and example 3, and it can be seen that the thermal effect curves of example 1, example 2 and example 3 are smooth, and the heat retention time is shorter as the temperature of the thermal effect is higher.
Finally, it should be noted that the above embodiments are merely representative examples of the present invention. It is obvious that the invention is not limited to the above-described embodiments, but that many variations are possible. Any simple modification, equivalent change and modification made to the above embodiments in accordance with the technical spirit of the present invention should be considered to be within the scope of the present invention.
Claims (4)
1. A preparation method of a plaster for treating injuries and relieving pain is characterized by comprising the following steps:
step 1, taking traditional Chinese medicine materials: 5g of clematis root, 10g of fried szechwan chinaberry fruit, 10g of prepared common monkshood mother root and 10g of star anise;
step 2, preparing a traditional Chinese medicine extract:
(1) preparing extract powder: pulverizing radix Clematidis, parched fructus Toosendan and radix Aconiti Preparata into coarse powder, placing into an extractor, adding 3-4 times of 70% ethanol according to weight, heating and reflux extracting at 75-85 deg.C for 2-3 hr; separating residue and liquid after reflux extraction, and filtering; concentrating the filtrate under reduced pressure to obtain soft extract, oven drying at 60 deg.C to obtain extract, and pulverizing the extract into fine powder to obtain extract powder 3.0-4.0 g;
(2) preparing star anise powder: taking 1.5-2.5g of star anise and crushing the star anise into fine powder;
(3) preparing star anise oil: taking 7.5-8.5g of star anise, crushing the star anise into coarse powder, putting the coarse powder into an extractor, adding 3-4 times of purified water according to the weight of the star anise, soaking for 1 hour, performing steam distillation extraction for 4-5 hours, and collecting 0.4-0.6g of star anise oil;
step 3, preparing a magnetic adhesive layer: uniformly stirring 2.0-3.0g of carboxymethyl chitosan mucilage, 4.5-5.5g of polyvinyl alcohol mucilage, 0.3-0.5g of glycerin and 2.2-2.8g of nano neodymium iron boron magnetic powder, uniformly coating the mixture on a core backing layer to form an oval shape, and drying at a low temperature of 60 ℃;
step 4, preparing a heating layer: uniformly mixing 1.5-2.0g of super absorbent resin, 2.0-2.4g of activated carbon, 0.2-0.4g of sodium chloride, 0.12-0.18g of polystyrene particles, 5.0-6.0g of iron powder, 4.5-5.5g of sodium polyacrylate adhesive cement and 1.8-2.2g of polyvinyl alcohol adhesive cement, pressing the mixture on a magnetic adhesive layer to form an oval thin layer, and then adhering a silica gel layer on a heating layer;
step 5, preparing a medicinal glue layer: mixing 1.5-2.5g fructus Anisi Stellati powder, 3.0-4.0g extract powder, 0.4-0.6g fructus Anisi Stellati oil, 0.5-0.7g glycerol, 3.5-4.5g carboxymethyl chitosan mucilage, and 7.0-8.0 g polyvinyl alcohol mucilage, coating into ellipse on release paper, drying at 60 deg.C, and sticking the medicinal colloid layer on the silica gel layer;
step 6, preparing the plaster: the plaster comprises a core backing layer, a magnetic adhesive layer, a heating layer, a silica gel layer, a medicine adhesive layer and release paper which are sequentially arranged from bottom to top, wherein the magnetic adhesive layer is formed by uniformly coating nano neodymium iron boron magnetic powder, carboxymethyl chitosan adhesive cement, polyvinyl alcohol adhesive cement and glycerin on the core backing layer and then drying at low temperature; the heating layer is formed by uniformly mixing iron powder, activated carbon, sodium chloride, super absorbent resin, sodium polyacrylate mucilage, polyvinyl alcohol mucilage and polystyrene particles and pressing the mixture on a magnetic adhesive layer; the silicone gel layer is a medical silicone gel dressing film and is stuck to the heating layer; the medicinal glue layer is formed by uniformly mixing a traditional Chinese medicine extract, glycerin, carboxymethyl chitosan glue paste and polyvinyl alcohol glue paste, coating the mixture on release paper, drying the mixture at low temperature, and then pasting the mixture with a silica gel layer, wherein the traditional Chinese medicine extract is composed of extract powder, star anise powder and star anise oil.
2. A method for preparing a patch for treating wound and stopping pain according to claim 1, wherein the carboxymethyl chitosan mucilage is prepared by the following steps: dispersing carboxymethyl chitosan in proper amount of purified water, swelling and suspending, dissolving in water bath at 60-70 deg.c, adding purified water to full amount, and stirring to form 5% concentration gelatin slurry.
3. The method for preparing a patch for relieving pain by promoting wound healing according to claim 1, wherein the sodium polyacrylate mucilage is prepared by the following steps: dispersing sodium polyacrylate in purified water, stirring for 20min, swelling, standing for several hours to dissolve completely, adding purified water to full volume, and stirring to obtain 1% gelatin slurry.
4. The method for preparing a patch for relieving pain by promoting wound healing according to claim 1, wherein the polyvinyl alcohol mucilage is prepared by the following steps: dispersing a specified amount of polyvinyl alcohol in a proper amount of purified water, and then placing the mixture on a water bath at 60-70 ℃ to dissolve the mixture into 8% of mucilage, wherein the polyvinyl alcohol is PVA 1788.
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| CN108498487A (en) * | 2018-04-24 | 2018-09-07 | 绍兴市中医院 | The warm magnetic reason that the injury of tendon and muscle is controlled outside a kind of hindering emplastrum |
| CN108771722A (en) * | 2018-07-20 | 2018-11-09 | 纪智仁 | A kind of Ji Shi channels sootheing and network vessel quickening thermal therapy patchs for treating neck-shoulder pain, lumbago and leg pain and rheumatism bone disease |
| CN109758564A (en) * | 2018-12-30 | 2019-05-17 | 无锡华粹堂健康管理有限公司 | A kind of Chinese medicine foot patch |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498487A (en) * | 2018-04-24 | 2018-09-07 | 绍兴市中医院 | The warm magnetic reason that the injury of tendon and muscle is controlled outside a kind of hindering emplastrum |
| CN108771722A (en) * | 2018-07-20 | 2018-11-09 | 纪智仁 | A kind of Ji Shi channels sootheing and network vessel quickening thermal therapy patchs for treating neck-shoulder pain, lumbago and leg pain and rheumatism bone disease |
| CN109758564A (en) * | 2018-12-30 | 2019-05-17 | 无锡华粹堂健康管理有限公司 | A kind of Chinese medicine foot patch |
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