CN113798678A - Method for inducing high-bioactivity surface of oral titanium alloy implant by laser - Google Patents
Method for inducing high-bioactivity surface of oral titanium alloy implant by laser Download PDFInfo
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- CN113798678A CN113798678A CN202111208355.6A CN202111208355A CN113798678A CN 113798678 A CN113798678 A CN 113798678A CN 202111208355 A CN202111208355 A CN 202111208355A CN 113798678 A CN113798678 A CN 113798678A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/60—Preliminary treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/70—Auxiliary operations or equipment
- B23K26/702—Auxiliary equipment
Abstract
The invention discloses a method for inducing a high-bioactivity surface of an oral titanium alloy implant by using laser. The ultrafast laser is utilized to manufacture a micro-nano structure on the surface of the titanium alloy, so that the biological activity of the oral titanium alloy implant is improved, and the rejection reaction of the implant in the oral cavity is reduced. The method has the advantages of flexible processing and high processing speed, and various accurate microstructures are obtained on the surface of the titanium alloy through a laser texture process, so that the cell growth is controlled, the bioactivity of the oral titanium alloy implant is improved, and the expected design function of the implant is achieved.
Description
Technical Field
The invention relates to a method for inducing a high-bioactivity surface of an oral titanium alloy implant by using laser, belonging to the technical field of material surface processing.
Background
Titanium and titanium alloys have the advantages of low density, no toxicity, high strength and good toughness, and also have an elastic modulus in metal materials that is similar to that of oral tissues. Moreover, the surface of titanium in tissue fluid can be oxidized to form a compact oxidation film, so that the corrosion resistance of titanium is greatly enhanced, and the oxidation film also endows titanium with excellent biocompatibility. The above advantages make titanium and titanium alloy the preferred materials for oral implants.
However, like most metal materials, titanium and titanium alloys are also biologically inert materials, which means that they do not chemically bond with bone tissues, and thus have problems of low bonding strength with oral tissues and difficulty in healing wounds in clinical use. Meanwhile, although the oxide film generated on the surface of titanium and titanium alloy gives a certain corrosion resistance, the oxide film is corroded to lose its effect and shorten the life of the implant under the complex physiological environment of human body for a long time. Further, metal ions generated after titanium and titanium alloys are corroded cause problems such as structural deterioration. Because a large amount of bacterial microorganisms exist in the complex microenvironment of the oral cavity, bacterial detention and colonization are inevitably formed around the oral implant, so that body cells and microorganisms are competitively attached to the surface of the oral implant material, and when the balance of immune response of a host machine body is broken, infection around the implant is caused and finally the oral implant operation is failed.
Because elements harmful to human bodies cannot be introduced into the implant, the selection of alloy elements in the process of developing a novel titanium alloy is limited, and the development difficulty is greatly increased. Therefore, it is a trend to modify the surface of titanium and titanium alloys to activate the surface. The laser surface treatment is a novel surface treatment technology which is mature day by day, and has the characteristics of flexible operation, no pollution and the like. Therefore, the surface of the titanium alloy material is modified by using the laser surface modification technology, so that the bioactivity of the oral titanium alloy implant material can be further improved.
Disclosure of Invention
The invention aims to provide a method for inducing a high-bioactivity surface of an oral titanium alloy implant by using laser. By a laser texture processing technology, a micro-nano structure is manufactured on the surface of the titanium alloy by utilizing ultrafast laser, cell growth is controlled, and the preparation of the high-bioactivity surface of the titanium alloy implant is realized.
The invention relates to a laser processing method for improving the bioactivity of an oral titanium alloy implant, which comprises the following specific steps:
s1, performing laser decontamination cleaning treatment on the titanium alloy sample;
s2, carrying out laser texture processing on the titanium alloy sample by adopting an ultrafast pulse laser to obtain a micro-nano structure pattern on the surface of the titanium alloy;
and S3, cleaning the processed titanium alloy.
The titanium alloy material S1 is a titanium alloy which can be used as a biomedical material, and comprises biomedical titanium alloys such as Ti13Nb13Zr, Ti12Mo6Zr2Fe, Ti15Mo, Ti15Mo5Zr3Al and Ti45 Nb;
s2, the ultrafast pulse laser is adopted for laser micro-nano processing, and the specific parameters are as follows: the laser wavelength is 193-1070 nm, the laser power is 0.5-300W, the pulse frequency is 1 k-5M Hz, the pulse width is 50 fs-200 ps, and the scanning speed is 10-3000 mm/s.
S2, the micro-nano structure graph obtained by the medium laser processing comprises: LIPSS structures, micro-cone structures, micro-groove structures, irregular structures, and combinations thereof. The LIPSS period is 10 nm-100 mu m; the height of the micro-cone structure is 50 nm-100 μm, and the distance is 50 nm-100 μm; the width of the micro-groove is 1-100 μm, and the depth is 5-100 μm; the roughness of the irregular structure is 1-100 nm.
The invention discloses a method for inducing a high-bioactivity surface of an oral titanium alloy implant by using laser. The method is characterized in that a micro-nano structure is manufactured on the surface of the titanium alloy by utilizing ultrafast laser, and the real morphology of the natural environment for cell growth is simulated to control the cell biological behavior. The biological activity of the oral titanium alloy implant is improved through a laser texturing process, and the expected design function of the implant is achieved.
The invention has the advantages that:
1. according to the method, the ultrafast laser is used for preparing the micro-nano structure pattern, the heat damage and the heat affected zone are small, various micro-nano patterns can be accurately prepared, and the original mechanical properties of the titanium alloy implant can be maintained.
2. The method utilizes the microstructure pattern to improve the characteristics of cell adhesion, differentiation and proliferation, and improves the bioactivity of the oral titanium alloy implant.
3. The method has the advantages of flexible processing and high processing speed, and is expected to improve the production efficiency in actual production.
Drawings
FIG. 1 is a schematic flow diagram of the process of the present invention;
FIG. 2 is an electron microscope image of a titanium alloy micro-nano structure prepared by ultrafast laser in embodiment 1;
FIG. 3 is an electron microscope image of the fibroblast culture morphology of the micro-nano structure sample in example 1.
Detailed Description
The present invention is further described with reference to the accompanying drawings and the detailed description so that the advantages and features of the present invention can be more readily understood by those skilled in the art, and the scope of the present invention is more clearly and clearly defined.
Example 1:
s1, grinding and polishing the Ti13Nb13Zr titanium alloy sample to 1000 meshes, ultrasonically cleaning the sample for 5 minutes by alcohol, and drying the sample;
s2, placing the titanium alloy sample under a femtosecond laser (with the wavelength of 1064nm), and carrying out laser texture processing on the surface of the titanium alloy, wherein the laser processing parameters are as follows: the power is 8W, the pulse width is 500fs, the frequency is 400kHz, the scanning speed is 800mm/s, the scanning distance is 70 mu m, and the LIPSS structure is obtained on the surface of the titanium alloy after 5 times of scanning;
and S3, cleaning the processed titanium alloy.
Example 2:
s1, grinding and polishing a Ti12Mo6Zr2Fe titanium alloy sample wafer to 1000 meshes, ultrasonically cleaning with alcohol for 5 minutes, and drying;
s2, placing the titanium alloy sample under a femtosecond laser (with the wavelength of 1064nm), and carrying out laser texture processing on the surface of the titanium alloy, wherein the laser processing parameters are as follows: the power is 20W, the pulse width is 500fs, the frequency is 400kHz, the scanning speed is 800mm/s, the scanning distance is 70 mu m, and the scanning is carried out for 5 times to obtain a micro-cone structure on the surface of the titanium alloy;
and S3, cleaning the processed titanium alloy.
Example 3:
s1, grinding and polishing the Ti15Mo titanium alloy sample to 1000 meshes, ultrasonically cleaning the sample for 5 minutes by alcohol, and drying the sample;
s2, placing the titanium alloy sample under a picosecond laser (wavelength of 1064nm), and carrying out laser texture processing on the surface of the titanium alloy, wherein the laser processing parameters are as follows: the power is 7W, the pulse width is 10ps, the frequency is 1MHz, the scanning speed is 2000mm/s, the scanning distance is 20 mu m, scanning is carried out for 10 times, and an irregular structure is obtained on the surface of the titanium alloy;
and S3, cleaning the processed titanium alloy.
Example 4:
s1, grinding and polishing a Ti45Nb titanium alloy sample to 1000 meshes, ultrasonically cleaning the sample for 5 minutes by alcohol, and drying the sample;
s2, placing the titanium alloy sample under a picosecond laser (wavelength of 1064nm), and carrying out laser texture processing on the surface of the titanium alloy, wherein the laser processing parameters are as follows: the power is 3W, the pulse width is 10ps, the frequency is 1kHz, the scanning speed is 200mm/s, the scanning distance is 50 mu m, scanning is carried out for 10 times, and a micro-groove structure is obtained on the surface of the titanium alloy;
and S3, cleaning the processed titanium alloy.
Claims (4)
1. A method for inducing a high-bioactivity surface of an oral titanium alloy implant by laser is characterized by comprising the following steps of:
and S2, performing laser texture processing on the titanium alloy sample by using an ultrafast pulse laser to obtain a micro-nano structure pattern on the surface of the titanium alloy.
2. The titanium alloy material as set forth in claim 1, which is a titanium alloy or the like that can be used for biomedical materials, including biomedical titanium alloys such as Ti13Nb13Zr, Ti12Mo6Zr2Fe, Ti15Mo, Ti15Mo5Zr3Al and Ti45 Nb.
3. The method of claim 1, wherein the ultrafast pulsed laser is used for the laser micro-nano processing, and the specific parameters are as follows: the laser wavelength is 193-1070 nm, the laser power is 0.5-300W, the pulse frequency is 1 k-5M Hz, the pulse width is 50 fs-200 ps, and the scanning speed is 10-3000 mm/s.
4. The micro-nano structure pattern obtained by laser processing as claimed in claim 1, comprising: LIPSS structures, micro-cone structures, micro-groove structures, irregular structures, and combinations thereof. The LIPSS period is 10 nm-100 mu m; the height of the micro-cone structure is 50 nm-100 μm, and the distance is 50 nm-100 μm; the width of the micro-groove is 1-100 μm, and the depth is 5-100 μm; the roughness of the irregular structure is 1-100 nm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114990546A (en) * | 2022-06-20 | 2022-09-02 | 贵州大学 | Method for preparing beta-type TixNb coating on TC4 surface by combining femtosecond laser with laser cladding, TC4 and application |
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| CN106392332A (en) * | 2016-10-11 | 2017-02-15 | 北京航空航天大学 | Laser veining method for improving surface cell adhesion of medical implants |
| CN108555437A (en) * | 2018-05-09 | 2018-09-21 | 北京航空航天大学 | A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth |
| CN109079446A (en) * | 2018-09-20 | 2018-12-25 | 北京航空航天大学 | A method of preparing antimicrobial surface on the medical instrument |
| CN109848546A (en) * | 2019-01-09 | 2019-06-07 | 北京科技大学 | A kind of titanium or titanium alloy surface micro-nano structure method of modifying |
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- 2021-10-18 CN CN202111208355.6A patent/CN113798678A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106392332A (en) * | 2016-10-11 | 2017-02-15 | 北京航空航天大学 | Laser veining method for improving surface cell adhesion of medical implants |
| CN108555437A (en) * | 2018-05-09 | 2018-09-21 | 北京航空航天大学 | A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth |
| CN109079446A (en) * | 2018-09-20 | 2018-12-25 | 北京航空航天大学 | A method of preparing antimicrobial surface on the medical instrument |
| CN109848546A (en) * | 2019-01-09 | 2019-06-07 | 北京科技大学 | A kind of titanium or titanium alloy surface micro-nano structure method of modifying |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114990546A (en) * | 2022-06-20 | 2022-09-02 | 贵州大学 | Method for preparing beta-type TixNb coating on TC4 surface by combining femtosecond laser with laser cladding, TC4 and application |
| CN114990546B (en) * | 2022-06-20 | 2023-06-02 | 贵州大学 | Method for preparing micro-nano structure TixNb coating on TC4 surface by combining femtosecond laser and laser cladding and application |
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Application publication date: 20211217 |