CN108555437A - A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth - Google Patents
A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth Download PDFInfo
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- CN108555437A CN108555437A CN201810439075.8A CN201810439075A CN108555437A CN 108555437 A CN108555437 A CN 108555437A CN 201810439075 A CN201810439075 A CN 201810439075A CN 108555437 A CN108555437 A CN 108555437A
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- laser
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
-
- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
- C21D1/00—General methods or devices for heat treatment, e.g. annealing, hardening, quenching or tempering
- C21D1/06—Surface hardening
- C21D1/09—Surface hardening by direct application of electrical or wave energy; by particle radiation
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F3/00—Changing the physical structure of non-ferrous metals or alloys by special physical methods, e.g. treatment with neutrons
Abstract
The invention discloses a kind of laser processings of orientation regulation and control biomedical metal material superficial cell growth.Relatively untreated biomedical metal material surface, in laser remolten process, material surface temperatures at localized regions rises sharply fusing, then it is quickly cooled down solidification, so that the component segregation of alloy is reduced, obtain close to uniform textura epidermoidea, and the corrosion rate of metal surface also declines therewith.Afterwards during laser texturing, focus on light beam is performed etching in material surface under the control of the computer, realizes scheduled micro- pattern topology processing, and the corrosion rate of texture processing rear region is also gone up.Pass through the process combining of laser remolten and laser texturing, the difference of biological metal surface region corrosion rate can artificially be controlled, it can above be realized in implantation material application and the influence of orientation regulation and control is generated to cell adherence, growth, extension, and then reach expected Functional Design.
Description
Technical field
The present invention relates to a kind of laser processings of orientation regulation and control biomedical metal material superficial cell growth.It can be by the party
Method is widely used in the surface treatment of biomedical metal material, and regulation and control can be oriented by being quickly obtained using laser remolten and texture processing
The metal surface of cell compartment growth, belongs to material surface processing technique field.
Background technology
The alloys such as magnesium, titanium, iron become one of research hotspot in recent years as bio-medical metal implant material.Biology
Medical alloy has good biocompatibility.Magnesium is the indispensable element of bone uptake as one of human body macroelement, excessive
Magnesium can be excreted by urine, will not cause toxic reaction.In addition, magnesium alloy has good mechanical compatibility, specific strength
With specific stiffness height, density and elasticity modulus can be effectively relieved stress-shielding effect, prevent secondary fracture closer to natural bone.
However the standard electrode potential of magnesium is low, easily corrodes, the Cl in body fluid-It can accelerate the corrosion of magnesium alloy, faster degradation speed
Rate can cause to be implanted into material premature corrosion failure, to cause the failure of implantation material treatment.Meanwhile too fast degradation rate meeting
With the release of hydrogen, bubble is formed around implant, implant ambient body fluid local ph can also increase, to shadow
Ring the treatment of the technical ability and implant site of implant surrounding tissue.Iron is as one of the essential trace elements of the human body, 70% iron
Exist in the form of hemoglobin, myoglobins etc., directly participates in the transhipment, exchange and tissue respiration process of internal oxygen.However it plants
Enter the iron that process excessively dissolves out, liver may be caused directly to damage, cause liver fibrosis and hepatic sclerosis, hepatocellular carcinoma etc..
Titanium or titanium alloy is known as biologically inert metal material, to having excellent corrosion resistance in the immersion environment of blood of human body
Can, it is good with the compatibility of blood of human body and cell tissue to ensure that, but equally exists digestion of metallic ion in practical applications and ask
Topic reduces its cell adaptation and is possible to do harm to huamn body.
From the aforegoing it can be seen that biomedical metal material faster degradation rate and digestion of metallic ion in human body are
Therefore its one of major issue faced in clinical practice application improves the corrosion resistance performance tool of biomedical metallic material
It is significant.Laser Surface Treatment has and operates flexibly, without dirt as a kind of increasingly mature novel surface treatment technology
The features such as contaminating, being selectively modified to parts locally surface, passes through laser remolten and laser texturing technique, Neng Gouti
The corrosion resistance on high biomedical metal material surface, and region design can be carried out to the degradation rate on surface, to realization pair
The orientation regulation and control of biomedical metal material superficial cell growth.In laser re-melting process, material surface temperature rises sharply rapid drawdown, metal
The component segregation of alloy is reduced after material solidification, which thereby enhances the corrosion resistance on biomedical metal material surface.In addition,
During laser texturing, due to the increase of surface area and large specific surface area at texture structure, corrosion rate also occurs centainly to return
It rises, the region of biomedical metal material surface corrosion rate is designed by presetting texture features realization.
Invention content
The purpose of the present invention is to provide a kind of laser processing sides of orientation regulation and control biomedical metal material superficial cell growth
Method passes through the laser processing technologies such as laser remolten and laser texturing, the regionally corruption on directed change biomedical metal material surface
Degradation rate is lost, attachment, distribution, growth, the extension of cell are controlled using the differentiation in different regions of biomedical metal material superficial degradation, from
And it realizes and the orientation of cell growth is regulated and controled.It is while improving biomedical metal material surface corrosion resistance energy, moreover it is possible to effectively
Ground meets the specific cells adhesiving effect of implantation material requirements.
A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth of the present invention, specific steps
For：
Step 1 is polished biomedical metal material matrix, cleaning treatment of deoiling；
Step 2, using continuous wave laser to being carried out by polishing, cleaned biomedical metal material surface of deoiling
Laser remolten processing obtains uniform remelted layer on biomedical metal material surface；
Step 3 is knitted using pulse laser to carrying out laser by laser remolten treated biomedical metal material surface
Structure processing obtains micro structure array on biomedical metal material surface；
Step 4 cleans the biomedical metal material after processing.
Wherein, the biomedical metal material be the magnesium base alloy that can be used for biomedical material, titanium-base alloy and
The materials such as stainless steel；
Wherein, laser remolten processing is carried out using continuous wave laser in step 2, design parameter is：Optical maser wavelength is
193~1070nm, laser power are 30~2000W, and sweep speed is 20~1500mm/s, and laser beam overlap ratio is 5~90%.
Wherein, laser texturing processing is carried out using pulse laser in step 3, design parameter is：Optical maser wavelength is
193~1070nm, laser power are 1~300W, and pulse frequency 1k~5M Hz, pulsewidth is 0.01~500ns, and sweep speed is
10~3000mm/s.
Wherein, the micro structure array that laser texturing obtains in step 3 comprising：Pit array, groove array, certain angle
The combination array of network and above structure that degree interlocks.Pit diameter is 20~100 μm, and recess width is 20~100
μm, array pitch is 30~500 μm, and constructional depth is 5~50 μm.
A kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth disclosed by the invention.Relatively not
The biomedical metal material surface of processing, in laser remolten process, material surface temperatures at localized regions rises sharply fusing, then fast
Fast cooled and solidified so that the component segregation of alloy is reduced, and is obtained close to uniform textura epidermoidea, and the corrosion rate of metal surface
Also decline therewith.Afterwards during laser texturing, material is melted or is vaporized by instantaneous high-temperature, each laser pulse is in object
Surface sputters a micropore, and under the control of the computer, laser facula carries out continuous movement punching, realizes scheduled micro- pattern shape
Looks are processed.And the corrosion rate of texture processing rear region increases also with the area corroded and is gone up.Pass through laser
The process combining of remelting and laser texturing can artificially control the difference of biological metal surface region corrosion rate, be implanted into
Material application can above be realized to cell adherence, growth, extend the influence for generating orientation and regulating and controlling, and then reaches expected function and set
Meter.
The advantage of the invention is that：
(1) this method can adapt to the weight of various biomedical metal materials using laser processing by changing laser parameter
Molten processing request, and texture pattern track and texture depth can be accurately controlled.
(2) for this method using laser processing, to material surface local fast heating and cooling, heat affecting is small, can keep
The original mechanical performance of biomedical metal material matrix.
(3) this method processing is flexible, and process velocity is fast, can adapt to variously-shaped, size material processing.
Description of the drawings：
The flow diagram of Fig. 1 present invention process processing
The electrode polarization curve graph of each step magnesium alloy print in Fig. 2 embodiments 1
The sem image of sample cell culture form after remelting and texture are processed in Fig. 3 embodiments 1
Specific implementation mode：
With reference to specific embodiment, the invention will be further described：
Embodiment 1
Step 1, by Mg-6Gd-0.6Ca magnesium alloy print sanding and polishings to 1000 mesh, alcohol ultrasonic cleaning 5 minutes,
It is dry；
Magnesium alloy print is placed under the continuous wave laser of wavelength 1060nm by step 2, and laser processing parameter is set as：Work(
Rate 80W, sweep speed 100mm/s, laser beam overlap ratio 40%, starting device carry out laser remolten, argon gas are used in reflow process
Protection, remelted layer is obtained in magnesium alloy sample surfaces；
Magnesium alloy sample after surface remelting is placed in Nd by step 3：It is right under YAG pulse lasers (wavelength 1064nm)
Laser texturing processing is carried out by laser remolten treated Mg alloy surface, laser processing parameter is set as：Power 7W, pulsewidth
600ps, frequency 500kHz, sweep speed 100mm/s, 400 μm of sweep span, 90 ° of grid angle, in Mg alloy surface acquisition side
Shape network array；
Step 4 cleans the magnesium alloy after processing.
Embodiment 2
Step 1, by WE43 magnesium alloy print sanding and polishings to 1000 mesh, alcohol ultrasonic cleaning 5 minutes is dry；
Magnesium alloy print is placed under the continuous wave laser of wavelength 1060nm by step 2, and laser processing parameter is set as：Work(
Rate 200W, sweep speed 300mm/s, laser beam overlap ratio 20%, starting device carry out laser remolten, argon are used in reflow process
Gas shielded obtains remelted layer in magnesium alloy sample surfaces；
Magnesium alloy sample after surface remelting is placed in Nd by step 3：It is right under YAG pulse lasers (wavelength 1064nm)
Laser texturing processing is carried out by laser remolten treated Mg alloy surface, laser processing parameter is set as：Power 10W, arteries and veins
Wide 600ps, frequency 500kHz, processing times 10,100 μm of sweep span obtain bowl configurations array in Mg alloy surface；
Step 4 cleans the magnesium alloy after processing.
Embodiment 3
Step 1, by Ti13Nb13Zr titanium alloy print sanding and polishings to 1000 mesh, alcohol ultrasonic cleaning 5 minutes is done
It is dry；
Titanium alloy print is placed under the continuous wave laser of wavelength 1060nm by step 2, and laser processing parameter is set as：Work(
Rate 200W, sweep speed 70mm/s, laser beam overlap ratio 70%, starting device carry out laser remolten, argon gas are used in reflow process
Protection, remelted layer is obtained on titanium alloy sample surface；
Titanium alloy sample after surface remelting is placed in Nd by step 3：It is right under YAG pulse lasers (wavelength 1064nm)
Laser texturing processing is carried out by laser remolten treated titanium alloy surface, laser processing parameter is set as：Power 15W, arteries and veins
Wide 600ps, frequency 500kHz, sweep speed 100mm/s, 400 μm of sweep span, groove structure battle array is obtained in titanium alloy surface
Row；
Step 4 cleans the titanium alloy after processing.
Embodiment 4
Step 1, by 316L stainless steel print sanding and polishings to 1000 mesh, alcohol ultrasonic cleaning 5 minutes is dry；
Stainless steel print is placed under the continuous wave laser of wavelength 1060nm by step 2, and laser processing parameter is set as：Work(
Rate 120W, sweep speed 120mm/s, laser beam overlap ratio 30%, starting device carry out laser remolten, argon are used in reflow process
Gas shielded obtains remelted layer in stainless steel sample surfaces；
Stainless steel sample after surface remelting is placed in Nd by step 3：It is right under YAG pulse lasers (wavelength 1064nm)
Laser texturing processing is carried out by laser remolten treated stainless steel surface, laser processing parameter is set as：Power 20W, arteries and veins
Wide 10ns, frequency 10kHz, sweep speed 200mm/s, 300 μm of sweep span, 60 ° of grid angle obtain water chestnut in stainless steel surface
Shape network array；
Step 4 cleans the stainless steel sample after processing.
Claims (5)
1. a kind of laser processing of orientation regulation and control biomedical metal material superficial cell growth, which is characterized in that comprising following
Step：
Step 1 is polished biomedical metal material matrix, cleaning treatment of deoiling；
Step 2, using continuous wave laser to carrying out laser by polishing, cleaned biomedical metal material surface of deoiling
Re melting process obtains uniform remelted layer on biomedical metal material surface；
Step 3, using pulse laser to being carried out at laser texturing by laser remolten treated biomedical metal material surface
Reason obtains micro structure array on biomedical metal material surface；
Step 4 cleans the biomedical metal material after processing.
2. the laser processing of orientation regulation and control biomedical metal material according to claim 1 surface growth, feature exist
In the biomedical metal material is that can be used for the materials such as the magnesium base alloy, titanium-base alloy and stainless steel of biomedical material
Material.
3. the laser processing of orientation regulation and control biomedical metal material according to claim 1 surface growth, feature exist
In carrying out laser remolten processing using continuous wave laser in the step two, design parameter is：Optical maser wavelength be 193~
1070nm, laser power are 30~2000W, and sweep speed is 20~1500mm/s, and laser beam overlap ratio is 5~90%.
4. the laser processing of orientation regulation and control biomedical metal material according to claim 1 surface growth, feature exist
In carrying out laser texturing processing using pulse laser in the step three, design parameter is：Optical maser wavelength be 193~
1070nm, laser power be 1~300W, pulse frequency 1k~5M Hz, pulsewidth be 0.01~500ns, sweep speed be 10~
3000mm/s。
5. the laser processing of orientation regulation and control biomedical metal material according to claim 1 surface growth, feature exist
In the micro structure array that laser texturing obtains in the step three comprising：Pit array, groove array, certain angle are handed over
The combination array of wrong network and above structure.Pit diameter is 20~100 μm, and recess width is 20~100 μm,
Array pitch is 30~500 μm, and constructional depth is 5~50 μm.
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Cited By (3)
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| CN111349930A (en) * | 2020-03-23 | 2020-06-30 | 北京工业大学 | Aluminum alloy laser surface composite modification method |
| CN113798678A (en) * | 2021-10-18 | 2021-12-17 | 北京航空航天大学 | Method for inducing high-bioactivity surface of oral titanium alloy implant by laser |
| CN114774815A (en) * | 2022-05-10 | 2022-07-22 | 西南交通大学 | Laser melting process beneficial to improving wear resistance of alloy |
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Cited By (3)
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| CN114774815A (en) * | 2022-05-10 | 2022-07-22 | 西南交通大学 | Laser melting process beneficial to improving wear resistance of alloy |
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