CN113797287A - Processing method and application for improving maltopentaose and maltohexaose in dendrobium officinale - Google Patents
Processing method and application for improving maltopentaose and maltohexaose in dendrobium officinale Download PDFInfo
- Publication number
- CN113797287A CN113797287A CN202111220124.7A CN202111220124A CN113797287A CN 113797287 A CN113797287 A CN 113797287A CN 202111220124 A CN202111220124 A CN 202111220124A CN 113797287 A CN113797287 A CN 113797287A
- Authority
- CN
- China
- Prior art keywords
- dendrobium officinale
- processed
- product
- percent
- fresh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001076416 Dendrobium tosaense Species 0.000 title claims abstract description 127
- FTNIPWXXIGNQQF-UHFFFAOYSA-N UNPD130147 Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(OC4C(OC(O)C(O)C4O)CO)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O FTNIPWXXIGNQQF-UHFFFAOYSA-N 0.000 title claims abstract description 29
- FJCUPROCOFFUSR-UHFFFAOYSA-N malto-pentaose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 FJCUPROCOFFUSR-UHFFFAOYSA-N 0.000 title claims abstract description 29
- FJCUPROCOFFUSR-GMMZZHHDSA-N maltopentaose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O[C@@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@@H](CO)O2)O)[C@@H](CO)O1 FJCUPROCOFFUSR-GMMZZHHDSA-N 0.000 title claims abstract description 29
- OCIBBXPLUVYKCH-QXVNYKTNSA-N alpha-maltohexaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](O[C@H](O[C@@H]3[C@H](O[C@H](O[C@@H]4[C@H](O[C@H](O[C@@H]5[C@H](O[C@H](O)[C@H](O)[C@H]5O)CO)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O OCIBBXPLUVYKCH-QXVNYKTNSA-N 0.000 title claims abstract description 27
- DJMVHSOAUQHPSN-UHFFFAOYSA-N malto-hexaose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(OC4C(C(O)C(O)C(CO)O4)O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 DJMVHSOAUQHPSN-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 238000003672 processing method Methods 0.000 title claims abstract description 8
- 239000002537 cosmetic Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 13
- 235000013376 functional food Nutrition 0.000 claims abstract description 9
- 230000003712 anti-aging effect Effects 0.000 claims abstract description 4
- 230000002087 whitening effect Effects 0.000 claims abstract description 3
- 239000000047 product Substances 0.000 claims description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000020510 functional beverage Nutrition 0.000 claims description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000011344 liquid material Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 6
- 235000019438 castor oil Nutrition 0.000 claims description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 210000002615 epidermis Anatomy 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 230000007413 intestinal health Effects 0.000 claims description 5
- 235000013372 meat Nutrition 0.000 claims description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- 229930003268 Vitamin C Natural products 0.000 claims description 4
- 238000004898 kneading Methods 0.000 claims description 4
- 230000001590 oxidative effect Effects 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 claims description 4
- 235000019154 vitamin C Nutrition 0.000 claims description 4
- 239000011718 vitamin C Substances 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 3
- 208000001132 Osteoporosis Diseases 0.000 claims description 3
- 229960005323 phenoxyethanol Drugs 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- 208000028774 intestinal disease Diseases 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 claims 2
- 238000012545 processing Methods 0.000 abstract description 6
- 238000001816 cooling Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 229940096919 glycogen Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 239000013062 quality control Sample Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- CVZZNRXMDCOHBG-QMMMGPOBSA-N 2-Chloro-L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1Cl CVZZNRXMDCOHBG-QMMMGPOBSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 description 1
- 229940035437 1,3-propanediol Drugs 0.000 description 1
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001523681 Dendrobium Species 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 208000025174 PANDAS Diseases 0.000 description 1
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 description 1
- 240000000220 Panda oleosa Species 0.000 description 1
- 235000016496 Panda oleosa Nutrition 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000006362 insulin response pathway Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000001195 ultra high performance liquid chromatography Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Polymers & Plastics (AREA)
- Physical Education & Sports Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides a special processing method and application for simultaneously improving maltopentaose and maltohexaose in dendrobium officinale. The method disclosed by the invention is used for processing the dendrobium officinale by using a special method, and in the processing process, after the fresh picked dendrobium officinale fresh strips are subjected to special treatment under the low temperature condition of-20 ℃, the dendrobium officinale fresh strips are baked for 12-36 hours under the temperature condition of 50-80 ℃, and then the dendrobium officinale processed products are obtained after cooling. The processed dendrobium officinale product is beneficial to the enrichment of maltopentaose and maltohexaose, has the content obviously higher than that of fresh strips, and can be directly eaten as functional food or used as a main raw material or an auxiliary material of functional cosmetics such as anti-aging and whitening cosmetics in the fields of cosmetics and medicine application.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine processing, functional food and cosmetics, and mainly relates to a special processing method for simultaneously improving maltopentaose and maltohexaose in dendrobium officinale, and application of the dendrobium officinale processed product in preparation of medicines, functional food and cosmetics.
Background
Dendrobium officinale, also known as "black clover", is a herb of Dendrobium of Orchidaceae, originally listed in Shen nong's herbal Jing and listed as the top grade, has the international title of panda in the pharmaceutical field, is the first of Jiuda Xiancao in Daozha, and attracts attention as a precious Chinese herbal medicine. The dendrobium officinale has wide pharmacological action and multiple biological activities of immunoregulation, anti-tumor, gastrointestinal tract regulation, oxidation resistance, aging resistance, fatigue resistance, blood sugar reduction, blood fat reduction, blood pressure reduction and the like. As a plant with homology of medicine and food, the dendrobium officinale has high application value in medical adjuvant therapy, health care nourishment, functional cosmetics and even medicinal raw materials.
The maltopentaose and maltohexaose are straight chain malto-oligosaccharide, which is formed by condensing alpha (1-4) chain D-glucose monomer and trace amount of (1-6) chain glucose, and the polymerization degrees are respectively 5 and 6. It has not only good processing adaptability, but also unique physiological function. Because maltopentaose and maltohexaose have low sweetness, they are often used as low sweeteners in foods with a soft mouthfeel. Meanwhile, maltopentaose and maltohexaose have strong water binding capacity and are widely applied to cosmetics as moisturizers. In addition, as a linear maltooligosaccharide, maltopentaoseThe maltohexaose and the maltohexaose can directly enter the small intestine without being digested by the stomach, and are hydrolyzed by alpha-glucosidase in the small intestine to enter blood to rapidly synthesize glycogen, so that the recovery of muscle glycogen and liver glycogen is accelerated, the insulin response and the blood glucose response caused by the maltohexaose are more stable than glucose, and the energy can be prolonged for a human body. Meanwhile, the formation of a large amount of lactic acid can be prevented during exercise, and the lactic acid-containing feed is an ideal energy supplement source for athletes and patients with liver and kidney diseases. Modern researches show that maltopentaose and maltohexaose can effectively promote human body to treat Ga2+The absorption of ions can further prevent osteoporosis of the middle-aged and the elderly. Moreover, it can selectively inhibit the growth of intestinal putrefactive microorganisms to promote the proliferation of beneficial microorganisms, thereby maintaining and improving the health of the intestinal environment. Therefore, it is widely used in the fields of food, medicine, cosmetics, and the like.
At present, the preparation of maltopentaose and maltohexaose is mainly carried out by an enzyme method, and the method is monopolized by Japan, has lower conversion rate and high cost. A large number of researches show that the traditional Chinese medicine and the extract thereof have the advantages of mild property, good tolerance, lasting effect and the like. The functional food and the cosmetics of plant origin are more in line with the safety requirements of consumers. In recent years, dendrobium officinale has attracted much attention because of its wide pharmacological actions. As a traditional Chinese herbal medicine, dendrobium officinale has a solid use foundation in regulating intestinal microorganisms and maintaining intestinal health, and is favored by more and more consumers in the application of cosmetics. The content of maltopentaose and maltohexaose as secondary metabolites of dendrobium officinale has an important effect on the pharmacological activity of dendrobium officinale. Therefore, it is very necessary to increase the content of maltopentaose and maltohexaose in dendrobium officinale.
Disclosure of Invention
The invention aims to provide a special processing method which is not reported in the prior art and can simultaneously improve the maltopentaose and the maltohexaose in the dendrobium officinale, a dendrobium officinale processed product prepared by the method, and application of the dendrobium officinale processed product in preparation of medicines, functional foods and cosmetics.
The above object of the present invention is achieved by the following means.
The dendrobium officinale processed product is prepared by the following method:
(1) selecting fresh stems of dendrobium officinale, removing fibrous roots, leaves and impurities, keeping stems, cleaning and then airing indoors;
(2) freezing the dried fresh stems in a refrigerator at-20 ℃ for 12 h;
(3) taking out the frozen fresh strips, placing in an oven, baking at 50-80 deg.C until the leaf sheaths are opened, taking out, kneading to remove membranous leaf sheaths, and avoiding damage to stem epidermis to expose internal meat quality, thereby oxidizing compounds;
(4) and continuously placing the dendrobium officinale stems without membranous leaf sheaths in an oven to bake for 24 hours at 50-80 ℃ to obtain the dendrobium officinale processed product.
According to the dendrobium officinale processed product, the content of maltopentaose in the dendrobium officinale processed product is increased by 4.49x10 compared with that of fresh strips11-1.65x1012The content of the malt hexaose is improved by 6.16x10 compared with that of the fresh strips11-9.11x1011And (4) doubling.
The invention also provides a processing method capable of simultaneously improving the maltopentaose and the maltohexaose in the dendrobium officinale, which comprises the following steps:
(1) selecting fresh stems of dendrobium officinale, removing fibrous roots, leaves and impurities, keeping stems, cleaning and then airing indoors;
(2) freezing the dried fresh stems in a refrigerator at-20 ℃ for 12 h;
(3) taking out the frozen fresh strips, placing in an oven, baking at 50-80 deg.C until the leaf sheaths are opened, taking out, kneading to remove membranous leaf sheaths, and avoiding damage to stem epidermis to expose internal meat quality, thereby oxidizing compounds;
(4) continuously placing the dendrobium officinale stems without membranous leaf sheaths in an oven to bake for 24 hours at 50-80 ℃ to obtain dendrobium officinale processed products;
wherein the content of maltopentaose in the processed product of Dendrobium officinale is increased by 4.49x10 compared with that in fresh strips11-1.65x1012The content of the malt hexaose is improved by 6.16x10 compared with that of the fresh strips11-9.11x1011And (4) doubling.
In addition, the invention also provides application of the dendrobium officinale processed product in preparing medicines for treating osteoporosis and intestinal diseases and resisting aging.
The dendrobium officinale processed product is applied to preparing functional food.
The dendrobium officinale processed product is applied to preparing a moisture-keeping cosmetic, and the mass fraction of the extract of the dendrobium officinale processed product in the moisture-keeping cosmetic is 1-30%.
The dendrobium officinale processed product is applied to preparing the energy-supplementing functional beverage, and the mass fraction of the extract of the dendrobium officinale processed product in the energy-supplementing functional beverage is 10-50%.
The dendrobium officinale processed product is applied to preparing the functional beverage for maintaining the intestinal health, and the mass fraction of the extract of the dendrobium officinale processed product in the functional beverage for maintaining the intestinal health is 20-60%.
The dendrobium officinale processed product is applied to preparing anti-aging and whitening cosmetics.
In addition, the invention also provides a dendrobium officinale functional beverage which comprises the following components in percentage by mass: 50.00 percent of dendrobium officinale extract, 0.20 percent of vitamin C, 0.01 percent of citric acid and 100 percent of deionized water; wherein the dendrobium officinale extract is obtained by extracting the dendrobium officinale processed product of claim 1 with a liquid-material ratio of 20:1 at 80 ℃ under reflux for 4 times, combining filtrates, and freeze-drying.
And the dendrobium officinale skin care essence comprises the following components in percentage by mass: 5.00 percent of dendrobium officinale extract, 1.00 percent of sodium hyaluronate, 4.00 percent of 1, 3-propylene glycol, 60.50 percent of polyacrylate cross-linked polymer, 0.20 percent of PEG-40 hydrogenated castor oil, 0.10 percent of PEG-60 hydrogenated castor oil, 0.05 percent of hydrogenated lecithin, 0.05 percent of EDTA disodium, 0.40 percent of phenoxyethanol and deionized water added to 100 percent; wherein the dendrobium officinale extract is obtained by extracting the dendrobium officinale processed product of claim 1 with a liquid-material ratio of 20:1 at 80 ℃ under reflux for 4 times, combining filtrates, and freeze-drying.
Compared with the prior art, the invention has the advantages that:
according to the method, the technical key lies in temperature and time control, and through the special processing method, the contents of maltopentaose and maltohexaose in the processed dendrobium officinale product are obviously improved compared with those of fresh strips. When the processing temperature is 50-80 deg.C, and baking for 24 hr, the content of maltopentaose in the processed product of herba Dendrobii is increased by 4.49x10 compared with fresh strips11-1.65x1012The content of the malt hexaose is improved by 6.16x10 compared with that of the fresh strips11-9.11x1011And when the temperature is lower than 50 ℃ or higher than 80 ℃, the content of maltopentaose and maltohexaose in the processed dendrobium officinale product is obviously improved compared with that of fresh dendrobium officinale product, and the dendrobium officinale product can be directly eaten as functional food or the extract of the dendrobium officinale product can be applied to foods such as functional beverage and the like, cosmetics and medicines.
Detailed Description
In order to make the objects, technical solutions, effects and advantages of the present invention more clear and obvious, the present invention is described below with reference to examples, but the present invention is not limited thereto. Simple modifications of the invention in accordance with its spirit fall within the scope of the invention.
Example 1
The special method is used for preparing the dendrobium officinale processed product which can simultaneously improve the maltopentaose and the maltohexaose in the dendrobium officinale.
(1) Selecting fresh stems of dendrobium officinale, removing fibrous roots, leaves and impurities, keeping stems, cleaning and then airing indoors.
(2) Freezing the dried fresh stem in a refrigerator at-20 deg.C for 12 h.
(3) And (3) taking out the frozen fresh strips, placing the fresh strips in an oven, baking the fresh strips at 60 ℃ until the leaf sheaths are opened, taking out the fresh strips, rubbing and removing the membranous leaf sheaths, and avoiding damaging the stem epidermis to expose the internal meat quality in the rubbing process so as to prevent the compound from being oxidized.
(4) And continuously placing the dendrobium officinale stems without membranous leaf sheaths in an oven to bake for 24 hours at the temperature of 60 ℃ to obtain the processed dendrobium officinale product.
Example 2
In this embodiment, the content changes of maltopentaose and maltohexaose in the processed dendrobium officinale product prepared in example 1 are mainly detected and analyzed, and the specific steps are as follows:
(1) the required medicines are as follows: methanol, formic acid, water, and acetonitrile were all obtained from Thermo, and L-2-chlorophenylalanine was obtained from Hengchuang Biotech, Inc. All chemicals and solvents were either analytically pure or chromatographic grade.
(2) Sample treatment: respectively weighing 500mg of fresh dendrobium officinale stems and the processed dendrobium officinale product prepared in example 1, completely grinding the samples, respectively weighing 80mg of the samples, and adding 20 mu L of internal standard (L-2-chlorophenylalanine, 0.3 mg/mL; methanol preparation) and 1mL of methanol-water (V: 7: 3); adding two small steel balls, standing at-20 deg.C for 2min for precooling, and adding into a grinder (60Hz for 2 min); ultrasonic extracting in ice water bath for 30min, standing overnight at-20 deg.C; centrifuge for 10min (13000rpm, 4 ℃), aspirate 150 μ L of supernatant with syringe, filter using a 0.22 μm organic phase pinhole filter, transfer to LC injection vial, store at-80 ℃ until LC-MS analysis. The quality control sample (QC) is prepared by mixing the extracting solutions of all samples in equal volume. All extraction reagents were pre-cooled at-20 ℃ before use.
(3) Analysis of metabolites: metabolic curves in ESI positive and ESI negative ion mode were analyzed using an ultra high performance liquid chromatograph (UHPLC, Dionex Ultimate 3000RS) equipped with a mass spectrometer (Q-active + quadrapole Orbitrap) with a heated electrospray ionization source (Thermo Fisher Scientific). Eluting with (A) water containing 0.1% (v/v) formic acid and (B) acetonitrile containing 0.1% (v/v) formic acid at a column temperature of 40 deg.C and a gradient of 0min, 5% B at 0.35 mL/min; 1min, 5% B; 2.5min, 30% B; 6min, 50% B; 7 min, 70% B; 10min, 80% B; 12 minutes, 100% B; 14min, 100% B; 14.2 min, 5% B; 16min, 5% B. During the analysis, the sample was kept at 4 ℃. The injection volume was 5. mu.L. The full MS scan used 70000 resolution and the high energy collision dissociation MS/MS scan used 17500 resolution with collision energies of 10, 20 and 40eV, respectively. The mass detected ranged between 100 and 1200 mass-to-charge ratios (m/z). The mass spectrometer works as follows: spray voltage, 3800V (+) and 3200V (-); sheath gas flow rate, 40 arbitrary units; assist gas flow rate, 15 arbitrary units; capillary temperature, 320 ℃; auxiliary gas heater temperature, 350 ℃; one QC sample was injected every fourth sample in order for the present invention to assess reproducibility.
(4) And (3) detection results:
TABLE 1 detection and analysis results of maltopentaose and maltohexaose in Dendrobium officinale processed by the special method of the present invention
From the above detection and analysis results, it can be seen that:
in the processed dendrobium officinale product prepared in example 1, when the processing temperature is 60 ℃ and the processed dendrobium officinale product is baked for 24 hours, the contents of maltopentaose and maltohexaose in the processed dendrobium officinale product are respectively increased by 1.65x10 compared with the contents of maltopentaose and maltohexaose in fresh strips12Multiple sum 9.11x1011And (4) doubling. Therefore, the content of maltopentaose and maltohexaose in the dendrobium officinale processed product prepared by the embodiment of the invention is obviously improved. Therefore, the dendrobium officinale processed product prepared by the embodiment of the invention can simultaneously improve the content of maltopentaose and maltohexaose, and has wide application in the fields of functional foods, medicines, cosmetics and the like.
Example 3
TABLE 2 preparation of functional beverage of Dendrobium officinale
| Components | Content (%) |
| Dendrobium officinale extract | 50.00 |
| Vitamin C | 0.20 |
| Citric acid | 0.01 |
| Deionized water | To 100 |
The dendrobium officinale functional beverage of example 3 is prepared according to the following steps:
(1) preparing a dendrobium officinale extract: the dried dendrobium officinale processed by the method is extracted by reflux for 4 times at the temperature of 80 ℃ according to the liquid-material ratio of 20:1, and the dendrobium officinale extract is obtained by freeze drying after the filtrates are combined.
(2) Adding the dendrobium officinale extract, the vitamin C and the citric acid in sequence according to the component proportion, supplementing the mixture to 100 percent by using deionized water, and uniformly mixing.
(3) After the dendrobium officinale extract is dissolved, the dendrobium officinale extract is sterilized by a filter membrane of 0.24um, and all operating bacteria are carried out under the aseptic condition.
Example 4
TABLE 3 preparation of skin care essence containing Dendrobium officinale
| Components | Content (%) |
| Dendrobium officinale extract | 5.00 |
| Hyaluronic acid sodium salt | 1.00 |
| 1, 3-propanediol | 4.00 |
| Polyacrylate cross-linkingBipolymer-6 | 0.50 |
| PEG-40 hydrogenated Castor oil | 0.20 |
| PEG-60 hydrogenated Castor oil | 0.10 |
| Hydrogenated lecithin | 0.05 |
| EDTA disodium salt | 0.05 |
| Phenoxyethanol | 0.40 |
| Deionized water | To 100 |
The dendrobium officinale skin care essence of example 4 is prepared according to the following steps:
(1) preparing a dendrobium officinale extract: the dried dendrobium officinale processed by the method is extracted by reflux for 4 times at the temperature of 80 ℃ according to the liquid-material ratio of 20:1, and the dendrobium officinale extract is obtained by freeze drying after the filtrates are combined.
(2) Adding oil, lipid and emulsifier into dissolving pan, heating at 70-80 deg.C and stirring to completely melt.
(3) Adding water soluble substance and deionized water into dissolving pot, heating at 90-100 deg.C and stirring for 20-30min to dissolve completely, and cooling to 70-80 deg.C.
(4) Adding the above prepared oil phase and water phase into emulsifying pot, heating and stirring at 70-80 deg.C for emulsifying for 10-20min, naturally cooling to room temperature, adding thermosensitive component, and stirring.
Example 5
Examples of pharmaceutical preparations:
firstly, preparing a dendrobium officinale extract: the dried dendrobium officinale processed by the method is extracted by reflux for 4 times at the temperature of 80 ℃ according to the liquid-material ratio of 20:1, and the dendrobium officinale extract is obtained by freeze drying after the filtrates are combined.
Then:
1. dissolving herba Dendrobii extract with small amount of DMSO, adding water for injection, fine filtering, bottling, and sterilizing to obtain injection.
2. Dissolving herba Dendrobii extract in small amount of DMSO, dissolving in sterile water for injection, stirring to dissolve, filtering with sterile suction filter funnel, performing sterile fine filtration, packaging, freeze drying at low temperature, and sealing under sterile condition to obtain powder for injection.
3. Taking the dendrobium officinale extract, adding an excipient according to the weight ratio of the dendrobium officinale extract to the excipient of 9:1, and preparing into powder.
4. Adding excipient into the dendrobium officinale extract according to the weight ratio of the dendrobium officinale extract to the excipient of 5:1, and preparing tablets.
5. Taking the dendrobium officinale extract, and preparing the dendrobium officinale extract into oral liquid according to a conventional oral liquid preparation method.
6. Adding excipient into the dendrobium officinale extract according to the weight ratio of the dendrobium officinale extract to the excipient of 5:1, and preparing into capsules.
7. Adding excipient into the dendrobium officinale extract according to the weight ratio of the dendrobium officinale extract to the excipient of 3:1, and preparing into capsules.
8. Adding excipient into the dendrobium officinale extract according to the weight ratio of the dendrobium officinale extract to the excipient of 5:1, and preparing into granules.
Claims (11)
1. The dendrobium officinale processed product is characterized by being prepared by the following method:
(1) selecting fresh stems of dendrobium officinale, removing fibrous roots, leaves and impurities, keeping stems, cleaning and then airing indoors;
(2) freezing the dried fresh stems in a refrigerator at-20 ℃ for 12 h;
(3) taking out the frozen fresh strips, placing in an oven, baking at 50-80 deg.C until the leaf sheaths are opened, taking out, kneading to remove membranous leaf sheaths, and avoiding damage to stem epidermis to expose internal meat quality, thereby oxidizing compounds;
(4) and continuously placing the dendrobium officinale stems without membranous leaf sheaths in an oven to bake for 24 hours at 50-80 ℃ to obtain the dendrobium officinale processed product.
2. The processed dendrobium officinale product of claim 1, wherein the content of maltopentaose in the processed dendrobium officinale product is increased by 4.49x10 compared with that in fresh dendrobium officinale product11- 1.65 x 1012The content of the malt hexaose is improved by 6.16x10 compared with that of the fresh strips11 - 9.11 x 1011And (4) doubling.
3. A processing method for simultaneously improving maltopentaose and maltohexaose in dendrobium officinale is characterized by comprising the following steps:
(1) selecting fresh stems of dendrobium officinale, removing fibrous roots, leaves and impurities, keeping stems, cleaning and then airing indoors;
(2) freezing the dried fresh stems in a refrigerator at-20 ℃ for 12 h;
(3) taking out the frozen fresh strips, placing in an oven, baking at 50-80 deg.C until the leaf sheaths are opened, taking out, kneading to remove membranous leaf sheaths, and avoiding damage to stem epidermis to expose internal meat quality, thereby oxidizing compounds;
(4) continuously placing the dendrobium officinale stems without membranous leaf sheaths in an oven to bake for 24 hours at 50-80 ℃ to obtain dendrobium officinale processed products;
wherein the content of maltopentaose in the processed product of Dendrobium officinale is increased by 4.49x10 compared with that in fresh strips11- 1.65 x 1012The content of the malt hexaose is improved by 6.16x10 compared with that of the fresh strips11 - 9.11 x 1011And (4) doubling.
4. The processed dendrobium officinale product of claim 1, and application thereof in preparing drugs for treating osteoporosis and intestinal diseases and anti-aging drugs.
5. The processed dendrobium officinale product of claim 1, and application thereof in preparing functional food.
6. The use of the processed dendrobium officinale product of claim 1 in the preparation of a moisturizing cosmetic, wherein the moisturizing cosmetic contains the extract of the processed dendrobium officinale product in an amount of 1-30% by mass.
7. The application of the dendrobium officinale processed product of claim 1 in preparing an energy-supplementing functional beverage, wherein the mass fraction of the extract of the dendrobium officinale processed product in the energy-supplementing functional beverage is 10-50%.
8. The application of the processed dendrobium officinale product of claim 1 in preparing a functional beverage for maintaining intestinal health, wherein the functional beverage for maintaining intestinal health contains the processed dendrobium officinale product extract with a mass fraction of 20-60%.
9. The processed dendrobium officinale product of claim 1, and application thereof in preparing anti-aging and whitening cosmetics.
10. The dendrobium officinale functional beverage is characterized by comprising the following components in percentage by mass: 50.00 percent of dendrobium officinale extract, 0.20 percent of vitamin C, 0.01 percent of citric acid and 100 percent of deionized water; wherein the dendrobium officinale extract is obtained by extracting the dendrobium officinale processed product of claim 1 with a liquid-material ratio of 20:1 at 80 ℃ under reflux for 4 times, combining filtrates, and freeze-drying.
11. The dendrobium officinale skin care essence is characterized by comprising the following components in percentage by mass: 5.00 percent of dendrobium officinale extract, 1.00 percent of sodium hyaluronate, 4.00 percent of 1, 3-propylene glycol, 60.50 percent of polyacrylate cross-linked polymer, 0.20 percent of PEG-40 hydrogenated castor oil, 0.10 percent of PEG-60 hydrogenated castor oil, 0.05 percent of hydrogenated lecithin, 0.05 percent of EDTA disodium, 0.40 percent of phenoxyethanol and deionized water added to 100 percent; wherein the dendrobium officinale extract is obtained by extracting the dendrobium officinale processed product of claim 1 with a liquid-material ratio of 20:1 at 80 ℃ under reflux for 4 times, combining filtrates, and freeze-drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111220124.7A CN113797287A (en) | 2021-10-22 | 2021-10-22 | Processing method and application for improving maltopentaose and maltohexaose in dendrobium officinale |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111220124.7A CN113797287A (en) | 2021-10-22 | 2021-10-22 | Processing method and application for improving maltopentaose and maltohexaose in dendrobium officinale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113797287A true CN113797287A (en) | 2021-12-17 |
Family
ID=78898039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111220124.7A Pending CN113797287A (en) | 2021-10-22 | 2021-10-22 | Processing method and application for improving maltopentaose and maltohexaose in dendrobium officinale |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113797287A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494284A (en) * | 2020-06-01 | 2020-08-07 | 中国科学院昆明植物研究所 | Dendrobium officinale extract processed by special method and application thereof in skin care products |
| CN112471374A (en) * | 2020-12-10 | 2021-03-12 | 梅州绿盛林业科技有限公司 | Freshly squeezed dendrobium officinale beverage and preparation method thereof |
| CN112494605A (en) * | 2021-01-12 | 2021-03-16 | 庐江县天地禾生物技术有限公司 | Processing method of medicinal dendrobium officinale |
-
2021
- 2021-10-22 CN CN202111220124.7A patent/CN113797287A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494284A (en) * | 2020-06-01 | 2020-08-07 | 中国科学院昆明植物研究所 | Dendrobium officinale extract processed by special method and application thereof in skin care products |
| CN112471374A (en) * | 2020-12-10 | 2021-03-12 | 梅州绿盛林业科技有限公司 | Freshly squeezed dendrobium officinale beverage and preparation method thereof |
| CN112494605A (en) * | 2021-01-12 | 2021-03-16 | 庐江县天地禾生物技术有限公司 | Processing method of medicinal dendrobium officinale |
Non-Patent Citations (3)
| Title |
|---|
| 刘亚净 等: "不同干燥炮制方法对石斛品质的影响研究", 《广东化工》 * |
| 林萍 等: "石斛属植物药理活性研究进展", 《中草药》 * |
| 欧阳伟虹 等: "不同干燥工艺对铁皮石斛有效成分及抗氧化活性影响", 《药物生物技术》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100750988B1 (en) | Composition having ginsenosides for treating or preventing diabetes | |
| KR100479803B1 (en) | Composition containing an extract of specially treated ginseng for preventing brain cells and treating brain stroke | |
| CN107998333B (en) | Preparation method of donkey-hide gelatin peptide product | |
| CN101472599A (en) | Visceral fat accumulation inhibitor, and agent for promoting the increase in and/or inhibiting the decrease in blood adiponectin level | |
| CN109010616A (en) | A kind of pure plant preparation for increasing beneficial bacteria of intestinal tract, improving intestinal flora | |
| CA2871478A1 (en) | Pleuropterus multiflorus extract and dipsacus asperoides extract for stimulating the secretion of insulin-like growth factor and promoting bone structure growth, and method for preparing same | |
| KR20040002742A (en) | A ginseng preparation using vinegar and process for thereof | |
| CN113797287A (en) | Processing method and application for improving maltopentaose and maltohexaose in dendrobium officinale | |
| CN115433248B (en) | Novel amino acid derivative separation and identification in red ginseng and novel application thereof | |
| CN111248440A (en) | Functional jasmine flower oligosaccharide oral liquid and application thereof | |
| CN109602759A (en) | The purposes of kusamaki broad-leaved podocarpus seed and receptacle polysaccharide | |
| KR102472951B1 (en) | A composition for immune enhancement comprising narrow-leaf erecta fig extract mixture | |
| Wang et al. | Extraction techniques, structural features and biological functions of Hippophae rhamnoides polysaccharides: A review | |
| CN112190644A (en) | Plant fermentation product, preparation method thereof and application of plant fermentation product in stomach health care | |
| JP2015098438A (en) | Sugar incorporation promoter | |
| CN112472733A (en) | A flos Puerariae Lobatae extract for promoting calcium oral absorption | |
| CN110959863A (en) | Stevia rebaudiana leaf mixed nutrient syrup and preparation method and application thereof | |
| CN110584126A (en) | Functional food with blood sugar reducing effect and preparation method thereof | |
| CN114712481B (en) | Composite plant source polypeptide and preparation method and application thereof | |
| CN112690351B (en) | Millettia speciosa-intelligence-improving tea beverage and preparation method and application thereof | |
| KR100456417B1 (en) | Composition containing an extract of specially treated ginseng for preventing brain cells and treating brain stroke | |
| JP5652078B2 (en) | New 4-vinylcatechol polymerization compound | |
| CN1280007A (en) | Jew's-ear blood fat regulating capsule | |
| US10548936B2 (en) | Method for reducing weight | |
| JPH10236967A (en) | Medicine comprising fermented material of glycyrrhiza |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211217 |