CN113731523B - Experiment table for extracting heparin sodium crude product - Google Patents

Abstract

The invention relates to the field of a heparin sodium preparation method, in particular to a experiment table for extracting a heparin sodium crude product, which comprises an experiment table body, wherein the experiment table body comprises a cabinet body, an operation platform is arranged at the upper end of the cabinet body, a dissolving treatment device, an enzymolysis treatment device, a centrifugal precipitation treatment device and a cleaning water tank are arranged on the operation platform, the cabinet body is provided with a purified water storage bin, a high-temperature storage bin, a low-temperature storage bin, a sterilization storage bin, a sewage storage bin and a sample storage bin to be tested, a purified water barrel can be placed in the purified water storage bin, the purified water storage bin is convenient to replace, and the high-temperature storage bin and the low-temperature storage bin are used for aging treatment in the experiment step.

Description

Experiment table for extracting heparin sodium crude product

Technical Field

The invention relates to the field of heparin sodium preparation methods, in particular to a laboratory table for extracting a heparin sodium crude product.

Background

The cardiovascular and cerebrovascular diseases are killers of the first disease of human beings, the morbidity and the mortality of the cardiovascular and cerebrovascular diseases are gradually increased along with the increase of the living standard of people, the occurrence rate and the mortality of the cardiovascular and cerebrovascular diseases are gradually increased, the appearance of heparin creates the wonderful life for a plurality of patients with the cardiovascular and cerebrovascular diseases, the heparin is the most effective anticoagulant medicament in the world at present and is the most clinically used, and is mainly applied to the treatment of the cardiovascular and cerebrovascular diseases and hemodialysis, wherein, the heparin is the only effective specific medicament in the hemodialysis treatment, the clinical application and research show that the heparin has various biological activities and clinical applications besides the anticoagulant effect, including the blood fat reducing effect, the anti-mesoderm Smooth Muscle Cell (SMC) proliferation, the promotion of the fibrinolysis and the like, in addition, the low molecular heparin is a large group of anti-blood medicaments which are further processed by taking heparin as a raw material, has wider clinical medical application and becomes a first choice medicine for treating diseases such as acute venous thrombosis, acute coronary syndrome (angina, myocardial infarction) and the like.

Heparin sodium is the glycosaminoglycan compound with the most complex molecular structure known to date, products for clinical application at present comprise heparin sodium, series of low-molecular heparin and the like, required raw materials can only be extracted from small intestine mucosa of pigs, raw materials of heparin raw material medicines are heparin crude products, the extraction of the heparin raw material medicines can only be derived from small intestine mucosa of healthy pigs, due to the fact that a large amount of impurities such as impurity proteins, impurity nucleic acids, microorganisms and the like are contained, the heparin with complete natural structural groups is directionally obtained through physical and chemical extraction and separation processes, and therefore the heparin raw material medicines are prepared The raw material of the crude product heparin sodium is subjected to quality evaluation, however, the existing crude product heparin sodium yield experiment mainly simulates a heparin sodium production process route, the process needs a plurality of procedures such as resin adsorption and elution, multiple oxidation, multiple low-power precipitation, drying and the like, and finally a heparin sodium sample for quality evaluation can be obtained within 5-7 days, so that the release of crude product heparin sodium detection and the production and operation of upstream crude product heparin sodium are seriously affected, therefore, the development of an efficient crude product heparin sodium yield experiment method is beneficial to enhancing the quality of the crude product heparin sodium by enhancing source control and improving the economic benefits of upstream and downstream heparin production enterprises, and the heparin sodium experiment is correspondingly carried out by an experiment table with a compact structure and complete functions, which is also an urgent need.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides a laboratory table for extracting a heparin sodium crude product, which has a compact structure and complete functions.

The invention is realized by the following technical scheme: a laboratory table for extracting a heparin sodium crude product comprises a laboratory table body, wherein the laboratory table body comprises a cabinet body, an operating platform is arranged at the upper end of the cabinet body, a dissolving treatment device, an enzymolysis treatment device, a centrifugal precipitation treatment device and a cleaning water tank are arranged on the operating platform, the cabinet body is provided with a purified water storage bin, a high-temperature storage bin, a low-temperature storage bin, a sterilization storage bin, a sewage storage bin and a sample storage bin to be tested, and the dissolving treatment device comprises a water supplementing device for supplementing purified water into a dissolving container and a stirring device for stirring the dissolving container;

the enzymolysis treatment device comprises a water bath heating device;

the cleaning water tank is connected with the sewage storage bin.

Further, the internal air conditioning system that is provided with of cabinet, air conditioning system includes compressor, condenser, liquid storage pot, expansion valve, evaporimeter, the condenser is including parallelly connected condenser one and the condenser two that sets up, condenser one is connected with water bath heating device, condenser two is connected with high temperature warehouse, the evaporimeter is including parallelly connected evaporimeter one and the evaporimeter two that sets up, evaporimeter one with wait that sample warehouse is connected, evaporimeter two is connected with low temperature warehouse, water bath heating device is connected with temperature control device.

Further, the temperature control device comprises a valve seat, a valve cavity is arranged on the valve seat, a valve core is arranged in the valve cavity, a refrigerant channel is arranged between the valve core and the valve cavity, the two ends of the valve core are both set to be conical, conical ports matched with the valve core are arranged at the two ends of the valve cavity, the two conical ports respectively correspond to refrigerant inlet pipes of the first condenser and the second condenser, and a driving device used for driving the valve core to move along the valve cavity is further arranged on the valve seat.

Furthermore, a guide rod is arranged on the side wall of the valve core, a guide groove matched with the guide rod is arranged on the side wall of the valve cavity, the driving device comprises a screw rod penetrating in the valve core, a threaded hole matched with the screw rod is formed in the valve core, the valve core and the screw rod are coaxially connected, and the screw rod extends to the outside of the valve seat and is connected with a rotating handle.

Further, the upper end of the cabinet body is provided with a back plate, the water supplementing device comprises a water storage barrel arranged on the back plate, and the lower end of the water storage barrel is connected with a faucet.

Furthermore, the stirring device comprises a suspension beam arranged on the back plate, a downward stirring motor is arranged at the tail end of the suspension beam, and an output shaft of the stirring motor is coaxially connected with a stirring rod through a drill chuck.

Further, a stirring rod storage box for placing a stirring rod is arranged on the back plate.

Furthermore, a container seat for fixing the dissolving container is arranged on the operating platform, and a light supplementing lamp is arranged on the container seat.

The invention has the beneficial effects that: experiment table for extracting heparin sodium crude product, including the experiment table body, the experiment table body includes the cabinet body, cabinet body upper end is provided with operation platform, last dissolving treatment device, enzymolysis treatment device, centrifugal precipitation treatment device, the washing basin of being provided with of operation platform, treat the experimental sample through dissolving treatment device and dilute, conveniently carry out experiment on next step, dissolving treatment device is including the moisturizing device that is used for replenishing purified water to dissolving the container, be used for the agitating unit to dissolving the container stirring, convenient operation, the treatment effeciency is high, enzymolysis treatment device includes water bath heating device, through the temperature of water bath heating device control enzymolysis process, and then can guarantee the stability of enzymolysis step, carry out centrifugal solid-liquid separation through centrifugal precipitation device, separation efficiency is high, the cabinet body is provided with purified water storage storehouse, high temperature storage storehouse, low temperature storage storehouse, Sterilization warehouse, sewage warehouse, treat sample warehouse, can place the purification cask in the purification water warehouse, conveniently change, high temperature warehouse, low temperature warehouse for the ageing treatment in the experimental procedure, through with each device integration on the laboratory bench, integrate the degree height, convenient to use.

Drawings

FIG. 1 is a schematic diagram of a laboratory bench;

FIG. 2 is a rear view of the laboratory bench;

FIG. 3 is a schematic view of a structure of a water replenishing device;

FIG. 4 is a schematic view of the stirring device;

FIG. 5 is a schematic cross-sectional view of a receptacle;

FIG. 6 is a schematic view of a structure of a stirring rod magazine;

FIG. 7 is a schematic cross-sectional view of a water bath heating apparatus;

FIG. 8 is a schematic view of the connection between the condenser and the evaporator;

FIG. 9 is a schematic cross-sectional view of a valve seat;

FIG. 10 is a schematic view of the sewage storage tank;

FIG. 11 is a schematic sectional view of a cleaning port;

figure 12 is a schematic top view of the comb plate;

wherein: 1-cabinet body, 2-back plate, 3-top plate, 4-water storage barrel, 5-container seat I, 6-container, 7-cantilever beam, 8-stirring motor, 9-stirring rod, 10-container seat II, 11-stirring rod storage box, 12-water bath, 13-centrifuge, 14-cleaning water tank, 15-sample storage bin, 16-low temperature storage bin, 17-high temperature storage bin, 18-tool box, 19-sterilization storage bin, 20-sewage storage bin, 21-purified water storage bin, 22-hoop, 23-water tap, 24-operation platform, 26-drill chuck, 27-stirring blade, 28-rubber seat, 29-splash-proof tank, 30-latex layer, 31-light supplement lamp, 32-glass plate, 33-cable, 34-buffer pad, 35-limit groove, 36-supporting rod, 37-ultraviolet lamp, 38-hanging nail, 39-comb plate, 40-water receiving groove, 41-rail, 42-condenser I, 43-heat insulation plate, 44-evaporator I, 45-evaporator II, 46-three-way valve, 47-compressor, 48-valve seat, 49-extension rod, 50-guide sleeve, 51-gear box, 52-rotary handle, 53-condenser II, 55-vulcanized rubber seat, 56-valve core, 57-refrigerant channel, 58-screw rod, 59-sewage tank, 60-cleaning port, 61-exhaust port, 62-gland, 63-water outlet, 64-sealing cover, 65-filter core, 66-protective cover, 67-the pin.

Detailed Description

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.

Example 1

As shown in fig. 1-12, a heparin sodium crude draws uses laboratory bench, including the laboratory bench body, the laboratory bench body includes the cabinet body 1, and operation platform 24 is installed to cabinet body upper end, and operation platform is made by the plank, and the surface covers corrosion resistant plate, and structural strength is high, and corrosion resistance is strong, binds through epoxy glue between corrosion resistant plate and the plank, and backplate 2 is installed to cabinet body upper end, makes things convenient for placement tool, and roof 3 is installed to the backplate upper end, and then can install lamps and lanterns.

The operation platform is provided with a dissolving treatment device, an enzymolysis treatment device, a centrifugal precipitation treatment device and a cleaning water tank 14.

Specifically, the dissolving treatment device comprises a water supplementing device for supplementing purified water into the dissolving container and a stirring device for stirring the dissolving container, wherein the water supplementing device comprises a water storage barrel 4 which is arranged on a back plate through an anchor ear 22, the water storage barrel is a transparent water barrel and is made of glass, the cleanness is high, the lower end of the water storage barrel is connected with a water tap 23, a purified water storage bin 21 is also arranged on the cabinet body, a door is arranged on the purified water storage bin to facilitate the replacement of the purified water barrel, the purified water barrel is arranged in the purified water storage bin and is communicated with the water storage barrel through a water pipe with a water pump, an exhaust nozzle is processed at the upper end of the water storage barrel and can exhaust in the water injection process so as to ensure the water injection stability, the water storage barrel is injected with water through a switch control pump, the water injection level is observed, the switch control is controlled through a switch, a measuring cup is selected for the dissolving container, the purified water amount is observed through scales during experiments, and further controlling the weight ratio of the purified water to the sample to be tested to be 9:1, in order to conveniently place the dissolving container under a water faucet, placing a container seat I5 right facing the water faucet on an operation platform, wherein the container seat I is a rubber seat, the lower end of the rubber seat is attached with a latex layer, a larger friction force is generated between the rubber seat I and the operation platform, a limiting groove 35 for placing the container is machined in the middle of the container seat I, and a splash-proof groove 29 is machined in the container seat I and positioned on the outer side of the limiting groove and can be used for machining the splash-proof groove to prevent liquid drops from splashing out onto the operation platform.

The centrifugal processing device is a centrifugal machine 13, and the rotating speed can reach 10000 rpm.

The stirring device comprises a suspension beam 7 arranged on a back plate, a downward stirring motor 8 is arranged at the tail end of the suspension beam, the suspension beam is connected with the back plate through a vertical rail 41 and can be manually operated to lift, so that a stirring rod is convenient to assemble and disassemble, an output shaft of the stirring motor is coaxially connected with a stirring rod 9 through a drill chuck 26, the drill chuck is generally used for clamping a drill bit of a drilling machine, the stirring device is a mature product, materials are convenient to obtain, the lower end of the stirring rod is provided with a stirring blade 27 which is a helical blade, axial flow is formed in the stirring process, the stirring efficiency is ensured, meanwhile, the cleaning is convenient, the stirring motor is a speed reducing motor, the stirring speed is controlled at 100rpm, splashing is prevented, a container is fixed in the stirring process for convenience, a container seat II 10 is placed on an operation platform and is also a rubber seat 28, a latex layer 30 is attached to the lower end of the rubber seat, and a larger friction force exists between the operation platform and the operation platform, a limiting groove for placing a container is processed in the middle of the container seat II, a splash-proof groove is further processed on the container seat II and positioned outside the limiting groove, the splash-proof groove is processed to prevent liquid drops from splashing to the operating platform, in addition, a light filling lamp 31 is further mounted on the container seat II for better observing solution changes in the stirring process, specifically, a light filling lamp mounting groove is processed in the middle of the limiting groove, the light filling lamp is an led lamp and is mounted in the light filling lamp mounting groove, a glass plate 32 is mounted at the upper end of the light filling lamp mounting groove, the thickness of the glass plate is 2mm, the glass plate is toughened glass, the structural strength is good, in order to avoid rigid contact between the glass plate and the container, a cushion pad 34 is laid at the upper end of the glass plate, the cushion pad is a silica gel ring, the thickness is 1mm, the transmittance is high, light filling can be carried out at the bottom of the container through the light filling lamp, and further the solution changes in the container can be better observed, the cable 33 of light filling lamp passes the outside extension of rubber seat, during the experiment, stir 5min, to treating that the sample dissolves completely, treat that the sample is crude heparin sodium, it stores up box 11 to install the puddler that is used for placing the puddler on the backplate, install the die-pin 36 that is used for the bearing puddler in the puddler stores up the box, processing has the recess with die-pin matched with on the die-pin, and then can guarantee bearing stability, store up box below at the puddler and install broach board 39, conveniently hang the puddler, the puddler upper end is fixed with peg 38 with broach board matched with, place the water receiving tank corresponding with the broach board on operation platform, puddler after the washing drips futilely on the broach board, receive the water through the water receiving tank, then place on the die-pin, still install ultraviolet lamp 37 in the puddler stores up the box, and then disinfect.

The enzymolysis treatment device comprises a water bath heating device, before the water bath heating, the pH value of the solution is adjusted to 6.0-8.0, the water bath heating is carried out at 50-60 ℃, proteolytic enzyme is added for enzymolysis, the temperature is kept for 2h, the enzymolysis step is finished in a high-temperature storage bin 17, after the enzymolysis is finished, the feed liquid is boiled for 5min, in the embodiment, the hydrolysis heating device comprises a water bath 12, the water bath is made of stainless steel plates, the butt joint part is sealed and welded, the good sealing effect is achieved, a water bath mounting opening corresponding to the water bath is processed on an operation platform, a heating device is arranged in a cabinet body, a heat insulation plate 43 is arranged on the outer side of the heating device, a polystyrene board is selected, the heat insulation effect is good, water is added into the water bath, then the heating device is used for heating, a water bath on the market can be used for heating, however, the size of the existing water bath is fixed, not fine adaptation experimental environment, and in this application, treat that sample storage storehouse, low temperature storage storehouse all need the heat exchange, are used for the water bath heating with the heat exchange, avoid the energy extravagant.

After boiling for 5min, cooling the material in the container to 0-10 ℃, then adjusting the pH value to 1.2-1.5, generating a large amount of precipitate, transferring the precipitate into a centrifuge for 5min, rotating at 4000rad/min, taking supernatant, adjusting the pH value to 9.0-10.0 back by using sodium hydroxide solution, heating to 28-32 ℃, adding hydrogen peroxide with the volume of 1% of the feed liquid at one time, oxidizing for more than 8 hours in a constant temperature box, and performing in the constant temperature box, wherein the temperature is 28-32 ℃ and is close to the room temperature, so that the energy-saving effect can be realized by using smaller power, in the embodiment, the cabinet body is further provided with a high-temperature storage bin 17, a low-temperature storage bin 16, a tool box 18 and a sterilization storage bin 19, the tool box is used for placing tools, the sterilization storage bin is used for placing the container 6, and in order to conveniently control the temperature of each module, the cabinet body is internally provided with an air conditioning system, and the air conditioning system comprises a compressor 47, The condenser comprises a condenser I42 and a condenser II 53 which are installed in parallel, the condenser I is connected with a water bath heating device, specifically, the heating device is a coil pipe to form the condenser I, the condenser II is connected with a high-temperature storage bin, the water bath heating device is connected with a temperature control device, the temperature control device comprises a valve seat 48, the valve seat is a stainless steel valve seat, the high-temperature resistance and the high-corrosion resistance are achieved, a valve cavity is machined on the valve seat, a valve core 56 is installed in the valve cavity, a refrigerant channel 57 is formed between the valve core and the valve cavity, specifically, the valve core is cylindrical and made of stainless steel materials, two ends of the valve core are both machined into cones, two ends of the valve cavity are provided with cone ports matched with the valve core, specifically, the valve seat is formed by buckling two valve pieces, the machining is convenient, the two valve pieces are positioned through a pin 67 and then are welded and sealed, the manufacturing is convenient, the conical ports are formed by vulcanized rubber seats, the vulcanized rubber seats have elasticity, the sealing effect is good, the corrosion resistance is high, the two conical ports respectively correspond to refrigerant inlet pipes of the first condenser and the second condenser, a driving device for driving the valve core to move along the valve cavity is further installed on the valve seat, a guide rod 68 is fixed on the side wall of the valve core, a guide groove matched with the guide rod is processed on the side wall of the valve cavity, the driving device comprises a screw rod 58 which is arranged in the valve core in a penetrating mode, a threaded hole matched with the screw rod is processed in the valve core, the valve core is coaxially connected with the screw rod, the screw rod extends to the outside of the valve seat and is connected with a rotary handle 52, specifically, the screw rod extends to the outside of the valve seat and is connected with a connecting rod 49, the connecting rod is sleeved with the connecting pipe, the connecting pipe is coaxially connected with the connecting rod, the connecting pipe is communicated with the refrigerant inlet pipe of the first condenser, a guide sleeve 50 is installed at the tail end of the connecting pipe, and the connecting rod and the connecting pipe are sealed through the guide sleeve, the extension rod extends to the outside of the extension pipe and is connected with a gear box 51, the gear box 51 is connected with a rotating handle, the rotating speed ratio between the rotating handle and the extension rod can be controlled through the gear box 51, a scale corresponding to the rotary handle is attached to the gear box, the scale is a temperature scale, the rotary handle rotates for an angle to drive the connecting rod to rotate in the use process, thereby driving the screw to rotate, the screw rotates to make the valve core move, further controlling the space between the valve core and the corresponding conical port to achieve the purpose of controlling the flow of the refrigerant, the purpose of controlling the temperature of the water bath is achieved by controlling the flow rate of the refrigerant flowing through the condenser I, the operation is convenient, no additional energy is required to be introduced, the compressor is a variable frequency compressor, according to the frequency of the condenser inlet temperature control and the control method of the variable frequency air conditioner, the temperature at the inlet end of the condenser can be guaranteed to be constant by a mature control means, and a basis can be provided for adjusting the water bath temperature.

The evaporator comprises a first evaporator 44 and a second evaporator 45 which are installed in parallel, the first evaporator is connected with the sample storage bin 15 to be tested, the second evaporator is connected with the low-temperature storage bin, and the sample storage bin and the low-temperature storage bin need constant temperatures and only need to control corresponding flow through a three-way valve 46.

During the experiment, after the oxidation is finished, centrifuging for 10min (4000 rad/min), collecting supernatant, adding 100mL of purified water into bottom sediment, washing, centrifuging for 10min (4000 rad/min) again, combining the two supernatants, then adjusting the neutrality of the feed liquid, diluting, adding 8% of total weight of sodium chloride, heating the feed liquid to 50-60 ℃ in a water bath, adding 0.46-time volume of medicinal ethanol, uniformly stirring, precipitating at 0-5 ℃ in a low-temperature storage bin, precipitating for 8h, removing supernatant and upper flocculent precipitate after the precipitation is finished, adding ethanol into bottom precipitate, grinding, performing suction filtration, drying in a 60 ℃ oven for 3-6 hours, collecting samples, packaging, and weighing to obtain the yield of the heparin sodium.

The cleaning water tank is connected with a sewage storage bin, in the invention, a sewage tank 59 is arranged in the sewage storage bin, the sewage tank is used for storing sewage containing organic matters in the cleaning water tank, in order to facilitate cleaning the sewage tank, a cleaning port 60 is processed at the upper end of the sewage tank, tools such as a brush and the like are conveniently extended into the sewage tank for cleaning, a gland 62 is arranged on the cleaning port, a water outlet 63 is processed on the gland, a sealing cover 64 is arranged on the water outlet, the sealing cover is sealed in the transferring process, in the using process, the sealing cover is opened, a water outlet pipe of the cleaning water tank is inserted into the sewage tank, in order to prevent odor from leaking, an exhaust port 61 is further processed at the upper end of the sewage tank, a filter element 65 is arranged at the exhaust port, the filter element is an active carbon filter element, a protective cover 66 is arranged at the upper end of the filter element, and sealing is prevented in the transferring process.

In summary, the experiment table for extracting the crude heparin sodium product provided by the invention comprises an experiment table body, the experiment table body comprises a cabinet body, an operation platform is arranged at the upper end of the cabinet body, a dissolving treatment device, an enzymolysis treatment device, a centrifugal precipitation treatment device and a cleaning water tank are arranged on the operation platform, a sample to be tested is diluted through the dissolving treatment device, the next experiment can be conveniently carried out, the dissolving treatment device comprises a water replenishing device for replenishing purified water into a dissolving container and a stirring device for stirring the dissolving container, the operation is convenient, the treatment precision is high, the enzymolysis treatment device comprises a water bath heating device, the temperature of the enzymolysis process is controlled through the water bath heating device, the stability of the enzymolysis step can be further ensured, the centrifugal precipitation device is used for carrying out centrifugal separation, the separation efficiency is high, and the cabinet body is provided with a purified water storage bin, a cleaning water storage bin and a cleaning water tank, High temperature warehouse, low temperature warehouse, sterilization warehouse, sewage warehouse, treat the sample warehouse, can place the purification cask in the purification water warehouse, conveniently change, high temperature warehouse, low temperature warehouse for the aging treatment in the experimental step, through with each device integration on the laboratory bench, the degree of integrating is high, convenient to use.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims (5)

1. The experiment table for extracting the crude heparin sodium product comprises an experiment table body, wherein the experiment table body comprises a cabinet body, and an operation platform is arranged at the upper end of the cabinet body;

the enzymolysis treatment device comprises a water bath heating device;

the cleaning water tank is connected with the sewage storage bin,

an air conditioning system is arranged in the cabinet body and comprises a compressor, a condenser, a liquid storage tank, an expansion valve and an evaporator, the condenser comprises a first condenser and a second condenser which are connected in parallel, the first condenser is connected with a water bath heating device, the second condenser is connected with a high-temperature storage bin, the evaporator comprises a first evaporator and a second evaporator which are connected in parallel, the first evaporator is connected with a storage bin for samples to be tested, the second evaporator is connected with a low-temperature storage bin, the water bath heating device is connected with a temperature control device,

the temperature control device comprises a valve seat, a valve cavity is arranged on the valve seat, a valve core is arranged in the valve cavity, a refrigerant channel is arranged between the valve core and the valve cavity, two ends of the valve core are both provided with cones, two ends of the valve cavity are provided with cone ports matched with the valve core, the two cone ports respectively correspond to refrigerant inlet pipes of the first condenser and the second condenser, a driving device for driving the valve core to move along the valve cavity is also arranged on the valve seat,

the valve core is characterized in that a guide rod is arranged on the side wall of the valve core, a guide groove matched with the guide rod is arranged on the side wall of the valve cavity, the driving device comprises a screw rod penetrating in the valve core, a threaded hole matched with the screw rod is formed in the valve core, the valve core is coaxially connected with the screw rod, and the screw rod extends to the outside of the valve seat and is connected with a rotating handle.

2. The experiment table for extracting crude heparin sodium product as claimed in claim 1, wherein a back plate is arranged at the upper end of the cabinet body, the water replenishing device comprises a water storage barrel arranged on the back plate, and the lower end of the water storage barrel is connected with a water tap.

3. The experiment table for extracting the crude heparin sodium product as claimed in claim 2, wherein the stirring device comprises a suspension beam arranged on a back plate, a downward stirring motor is arranged at the tail end of the suspension beam, and an output shaft of the stirring motor is coaxially connected with a stirring rod through a drill chuck.

4. The laboratory bench for heparin sodium crude extraction according to claim 3, wherein a stirring rod storage box for placing a stirring rod is arranged on the back plate.

5. The experiment table for extracting the crude heparin sodium product according to claim 1, wherein a container seat for fixing a dissolving container is arranged on the operation platform, and a light supplement lamp is arranged on the container seat.

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