CN113730375B

CN113730375B - Preparation equipment for melt preparation of diclofenac sodium sustained-release composition and preparation process thereof

Info

Publication number: CN113730375B
Application number: CN202111037746.6A
Authority: CN
Inventors: 卞建钢; 潘秀芝; 刘秀朋; 李吉林; 安术欣; 张华魏; 邵黎明
Original assignee: DEZHOU DEYAO PHARMACEUTICAL CO LTD
Current assignee: DEZHOU DEYAO PHARMACEUTICAL CO LTD
Priority date: 2021-09-06
Filing date: 2021-09-06
Publication date: 2022-12-09
Anticipated expiration: 2041-09-06
Also published as: CN113730375A

Abstract

The invention relates to the technical field of preparation of diclofenac sodium slow-release compositions, in particular to a preparation device for preparing a diclofenac sodium slow-release composition by melting and a preparation process thereof; the preparation equipment comprises a smelting furnace body, wherein a crushing mechanism is arranged on the smelting furnace body, a conveying mechanism is arranged in the crushing mechanism, a cooling mechanism is arranged in the crushing mechanism, two locking mechanisms are arranged in the crushing mechanism, a protection mechanism is connected in the crushing mechanism, and a discharging mechanism is connected on the smelting furnace body; improved waxy material through damaged mechanism's effect and melted efficiency, made things convenient for the material to carry through conveying mechanism, prevented to block up, be favorable to dispelling the heat cooling to broken mechanism under the effect through cooling body, improved working life to make damaged mechanism installation stable under the effect through blocked mechanical system, and make things convenient for subsequent maintenance clearance, through arranging the convenient quick smooth and easy discharge of material mechanism, prevent to block up.

Description

Preparation equipment for melt preparation of diclofenac sodium slow-release composition and preparation process thereof

Technical Field

The invention relates to equipment for preparing a diclofenac sodium slow-release composition, in particular to equipment for preparing a diclofenac sodium slow-release composition by melting and a preparation process thereof, belonging to the technical field of preparation of diclofenac sodium slow-release compositions.

Background

Diclofenac sodium belongs to a second generation of powerful non-steroidal anti-inflammatory drugs, has obvious effects of analgesia, inflammation diminishing and fever reduction, and inhibits the synthesis of arachidonic acid by inhibiting cyclooxygenase in vivo so as to reduce the synthesis of prostaglandin, thereby playing roles of antirheumatic, inflammation diminishing, analgesia and antipyresis.

Patent numbers: 201810835414.4 a diclofenac sodium slow-release composition and its preparation method can carry on diclofenac sodium slow-release composition preparation with high efficiency, however when diclofenac sodium slow-release composition is prepared, the wax material is thrown into the melting furnace directly to melt, because the wax material is bulky, the speed is slow when the chunk melts, the whole preparation efficiency is reduced, meanwhile, the wax material has certain viscosity, the resistance is large when the equipment is broken, a large amount of heat can be produced, the equipment needs to be fully cooled, the service life of the equipment can be ensured, meanwhile, the flow rate is slow when the material is conveyed, the inner pipeline is easy to be blocked, and the discharge outlet is inconvenient to dredge, which affects the subsequent conveying work.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides a preparation device for melt-preparing a diclofenac sodium slow-release composition and a preparation process thereof.

In order to solve the technical problems, the preparation equipment for preparing the diclofenac sodium slow-release composition by melting and the preparation process thereof provided by the invention comprise a melting furnace body, wherein a crushing mechanism is arranged on the melting furnace body, a conveying mechanism is arranged in the crushing mechanism, a cooling mechanism is arranged in the crushing mechanism, two locking mechanisms are arranged in the crushing mechanism, a protection mechanism is connected in the crushing mechanism, and a discharging mechanism is connected on the melting furnace body;

the material discharging mechanism comprises a fixed block, the fixed block is detachably connected to the smelting furnace body, a material discharging groove is formed in the fixed block, a plurality of guide plates which are symmetrically distributed at equal intervals are arranged in the material discharging groove, the smelting furnace body is connected with the outside through the material discharging groove, an air discharging groove is formed in the fixed block, a connecting pipe is connected to the fixed block through a thread, the connecting pipe is connected with the inside of the material discharging groove through the air discharging groove, and an included angle between the air discharging groove and the material discharging groove is 30 degrees;

the inside rotation of fixed block is connected with the rubber slab, the rubber slab is the trapezium structure, rubber slab one side and row material groove intercommunication, the rubber slab opposite side is contradicted with the fixed block, it is connected with the actuating lever to rotate on the rubber slab, the inside sliding connection of fixed block has the slider, the actuating lever rotates with the slider to be connected, the inside threaded connection of slider has the lead screw, the lead screw extends to the fixed block outside, fixedly connected with nut on the lead screw, the lead screw rotates with the fixed block to be connected, the inside air guide groove that is equipped with of fixed block, the air discharge duct is through air guide groove and rubber slab one side intercommunication.

Specifically, broken mechanism includes the fixing base, install the fixing base on the smelting pot body, the block is connected with the mount pad on the fixing base, can dismantle on the mount pad and be connected with the motor, inside movable groove and the pivot of being equipped with of mount pad, the pivot is connected with the rotation of movable inslot portion, the pivot is connected with the motor, install crushing sword in the pivot, movable groove and the inside intercommunication of smelting pot body, be connected with two handles on the mount pad, be connected with the feeder hopper on the mount pad, feeder hopper and the inside intercommunication of movable inslot portion, mount pad internally mounted has the screen cloth, the movable groove passes through screen cloth and the inside intercommunication of smelting pot body.

Specifically, conveying mechanism includes the hob, the inside rotation of fixing base is connected with the hob, the hob extends to the smelting pot body inside, be connected with first helical gear on the hob, the inside rotation of mount pad connects the connecting rod, install the second helical gear on the connecting rod, second helical gear and the perpendicular meshing of first helical gear, the connecting rod extends to the activity inslot portion and is connected with the pivot block, pivot and connecting rod junction are hexagonal structure, first helical gear diameter is greater than the diameter of second helical gear.

Specifically, cooling body includes the aqua storage tank, the inside aqua storage tank that is equipped with loop configuration of mount pad, be connected with two inlet tubes and two outlet pipes on the mount pad, the inside guide slot that is equipped with of mount pad, the inlet tube passes through guide slot and aqua storage tank intercommunication, outlet pipe and the inside intercommunication of aqua storage tank.

Specifically, the inside two leather plugs that are equipped with of mount pad, be connected with compression spring on the leather plug, the leather plug passes through compression spring and mount pad sliding connection, inlet tube and leather plug top intercommunication, guide slot and leather plug lateral wall intercommunication, the leather plug is cylindrical structure.

Specifically, blocked mechanical system includes the bayonet lock, the inside bayonet lock that is equipped with two symmetries of mount pad, be connected with reset spring on the bayonet lock, the bayonet lock passes through reset spring and mount pad sliding connection, be equipped with two draw-in grooves on the fixing base, the bayonet lock runs through in mount pad and the inside block of draw-in groove, be connected with the depression bar on the bayonet lock, the depression bar extends to the mount pad outside, the depression bar passes through bayonet lock and mount pad sliding connection.

Specifically, the bayonet lock is of an L-shaped structure, one end of the bottom of the bayonet lock is of a triangular structure, a pressing plate is connected to a pressing rod, and the pressing plate is of an oval structure.

Specifically, the protection mechanism includes the slide bar, two be connected with the slide bar on the leather plug, the slide bar runs through in compression spring and the inside sliding connection of mount pad, be equipped with logical groove on the slide bar, be connected with the ejector pin on the bayonet lock, ejector pin and mount pad sliding connection, the ejector pin with lead to the groove intercommunication, ejector pin width and thickness are less than logical groove inside width and thickness.

Specifically, the detection method of the preparation equipment for preparing the diclofenac sodium sustained-release composition by melting comprises the following steps:

s1: firstly, crushing a large waxy material under the action of a crushing mechanism;

s2: the conveying mechanism is driven to operate through the work of the crushing mechanism, and the materials crushed by the crushing mechanism are conveyed under the action of the conveying mechanism, so that the materials are guided into the smelting furnace body;

s3: when the crushing mechanism works, the crushing mechanism is subjected to circulating water heat dissipation and cooling under the action of the cooling mechanism, and the crushing mechanism is subsequently detachably mounted and separated under the action of the locking mechanism;

s4: melting waxy material to obtain melt, conveying and discharging the melt into the fluidized bed under the action of a discharging mechanism, mixing diclofenac sodium and hydrophilic material in the fluidized bed to form a mixture, spraying the melt into the fluidized bed, mixing the melt with the mixture for granulating, and cooling to obtain the diclofenac sodium sustained-release composition, wherein the capsule filling equipment is a pellet capsule filling machine.

The invention has the beneficial effects that:

(1) According to the preparation equipment and the preparation process for preparing the diclofenac sodium slow-release composition by melting, the waxy material is conveniently melted under the action of the melting furnace body, and massive waxy material is favorably crushed under the action of the damage mechanism, so that the waxy material is melted more quickly in the melting furnace body, the melting efficiency is improved, the material is better poured into the melting furnace body under the action of the conveying mechanism, the material is prevented from being blocked, and the efficiency is reduced, namely: conveniently install this body coupling of mount pad and smelting pot through the effect of fixing base down, when melting waxy material, throw into the movable groove inside earlier waxy material, then switch on makes motor work, and make the motor drive crushing sword rotate inside the movable groove, be favorable to cutting up waxy material, and flow in and carry out melting work inside the smelting pot, the efficiency that waxy material melts has been improved, conveniently separate mount pad and fixed base under the effect through the handle, make things convenient for subsequent maintenance clearance work, conveniently throw into the inside crushing work that carries out of movable groove through the feeder hopper simultaneously, and screen out through the screen cloth, make kibbling more even, after mount pad and fixing base block, the connecting rod can be connected with the pivot block, be favorable to making the pivot drive the connecting rod when rotating and rotate, and through the transmission of second helical gear and first helical gear, make the second helical gear rotate bottom the screen cloth, be favorable to making the material that the screen cloth dropped derive to the smelting pot body inside through the helical rod and carry out melting work, prevent material blocking, reduce efficiency, be favorable to making pivot and drive the connecting rod rotation of connecting rod after connecting rod block is connected, simultaneously second helical gear and first helical gear and be favorable to the rotation more than the helical gear, and make the material carry more fine.

(2) According to the preparation equipment and the preparation process for preparing the diclofenac sodium slow-release composition by melting, the crushing mechanism is favorably cooled by heat dissipation under the action of the cooling mechanism, the service life is prolonged, the damaged mechanism is stably installed under the action of the locking mechanism, and the subsequent maintenance and cleaning are convenient, namely: through inlet tube and outlet pipe and external cooling machine's being connected, thereby make cold water carry to the aqua storage tank inside through inlet tube and guide slot, be favorable to cooling the heat dissipation to the motor of work, water after the cooling can be discharged through the outlet pipe, thereby realize circulative cooling's work, the life of motor has been prolonged, after cold water gets into through the inlet tube, cold water can extrude the leather plug and break away from the effect of compression spring and slide down, thereby make inlet tube and guide slot intercommunication, thereby make cold water get into the aqua storage tank inside, damage when water pressure undersize or cooler makes, make the leather plug reset under compression spring's effect, thereby block up the guide slot, make the inside water of aqua storage tank can not flow back, make the aqua storage tank inside can not cause dry and withered to influence to dispel the heat the motor simultaneously, after mount pad and fixing base block, the bayonet lock is with the inside block of reset spring under the effect, thereby make mount pad and the spacing difficult separation of fixing base, when pressing down, make the drive bayonet lock reset spring's effect with the inside separation of draw-in groove through convenient conflict of handle, be favorable to the bayonet lock, make the bayonet lock convenient operation, make the depression bar push down the convenient operation of extrusion.

(3) The preparation equipment and the preparation process for preparing the diclofenac sodium slow-release composition by melting are beneficial to limiting the locking mechanism by the protection mechanism through the driving of the cooling mechanism under the action of the protection mechanism, so that the locking mechanism is not easy to drive, the effect of protecting a damaged mechanism is achieved, and the safety coefficient of production is improved, namely: through the slip of bayonet lock to drive the ejector pin and slide at logical inslot portion, after the leather plug receives water pressure gliding, make the slide bar gliding, thereby make and lead to the inslot and slide to the mount pad is inside to be hidden, when the bayonet lock need slide, the ejector pin can contradict with the slide bar lateral wall, thereby make the bayonet lock be difficult for sliding, make the bayonet lock difficult by the drive in the cooling process, prevent mount pad and fixing base separation, thereby played the effect of protection.

(4) According to the preparation equipment and the preparation process for preparing the diclofenac sodium slow-release composition by melting, the melted materials in the melting furnace body can be conveniently and quickly conveyed and discharged under the action of the discharging mechanism, so that the conveying efficiency is improved, and the melting furnace body is conveniently dredged to prevent blockage from influencing the subsequent discharging work, namely: through outside pipeline with being connected of fixed block one end, be favorable to the material of smelting pot body inside passes through the blow-off tank is carried to outside inside the pipeline, simultaneously through connecting the connecting pipe makes outside gas pass through the connecting pipe gets into inside the air discharge duct, and through the air discharge duct is right the pressurization of blow-off tank inside makes the material of the interior of blow-off tank is carried and is difficult for blockking up fast, is a plurality of be favorable to making the smooth and easy difficult backward flow of discharged material transport under the effect of guide plate, through rotating the nut makes the lead screw is right under the effect of screw slider drive, the slider can conflict the actuating lever gliding, thus right the rubber slab is contradicted and is rotated, works as after the rubber slab rotates certain position, the gas of the interior of air discharge duct passes through the air guide duct gets into rubber slab one side, and through the rubber slab is right the blow-off tank with the drive pole body is inside blows up to be favorable to making the material of smelting pot body mouth discharge, prevent that material jam can's unable entering the interior of blow-off tank is carried, works as reverse rotation the slider, thereby makes the pulling the rubber slab rotates the closure makes the actuating lever the closure make the air guide duct with the follow-up tank closure is convenient follow-up material transport nut.

Drawings

The invention is further illustrated with reference to the following figures and examples.

FIG. 1 is a schematic structural diagram of a preferred embodiment of the preparation equipment and preparation process for melt-preparing diclofenac sodium sustained-release composition provided by the invention;

FIG. 2 is an enlarged view of the portion A shown in FIG. 1;

FIG. 3 is a schematic view of the connection structure of the crushing mechanism, the cooling mechanism and the locking mechanism shown in FIG. 2;

FIG. 4 is an enlarged view of the portion B shown in FIG. 3;

FIG. 5 is an enlarged view of the portion C shown in FIG. 3;

FIG. 6 is a schematic view of the screw rod of FIG. 5;

FIG. 7 is an enlarged view of the portion D shown in FIG. 1;

fig. 8 is a schematic view illustrating a connection structure of the fixing block and the connection pipe shown in fig. 7;

FIG. 9 is an enlarged view of section E of FIG. 8;

FIG. 10 is a flow chart of the preparation process for melt-preparing a diclofenac sodium sustained release composition provided by the present invention.

In the figure: 1. a furnace body; 2. a crushing mechanism; 21. a fixed seat; 22. a feed hopper; 23. a mounting base; 24. a handle; 25. a motor; 26. a rotating shaft; 27. a crushing knife; 28. a movable groove; 29. screening a screen; 3. a cooling mechanism; 31. a water inlet pipe; 32. a water outlet pipe; 33. a water storage tank; 34. a guide groove; 35. a plug of leather; 36. a compression spring; 4. a locking mechanism; 41. a pressure lever; 42. a bayonet lock; 43. a card slot; 44. a return spring; 45. pressing a plate; 5. a conveying mechanism; 51. a screw rod; 52. a first helical gear; 53. a second helical gear; 54. a connecting rod; 6. a protection mechanism; 61. a slide bar; 62. a through groove; 63. a top rod; 7. a discharging mechanism; 71. a fixed block; 72. a connecting pipe; 73. a nut; 74. a discharge chute; 75. an exhaust duct; 76. a baffle; 77. a rubber plate; 78. a gas guide groove; 79. a drive rod; 79a, a slider; 79b and a screw rod.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in fig. 1 to fig. 9, the apparatus for preparing a diclofenac sodium sustained-release composition by melting and the process for preparing the diclofenac sodium sustained-release composition provided by the invention comprises a melting furnace body 1, a crushing mechanism 2 is installed on the melting furnace body 1, a conveying mechanism 5 is installed inside the crushing mechanism 2, a cooling mechanism 3 is arranged inside the crushing mechanism 2, two locking mechanisms 4 are installed inside the crushing mechanism 2, a protection mechanism 6 is connected inside the crushing mechanism 2, and a discharging mechanism 7 is connected on the melting furnace body 1.

Specifically, it includes fixed block 71 to arrange material mechanism 7, it is connected with fixed block 71 to dismantle on the smelting furnace body 1, fixed block 71 is inside to be equipped with row material groove 74, row material groove 74 internally mounted has a plurality of equidistance symmetric distribution's guide plate 76, smelting furnace body 1 passes through row material groove 74 and external connection, fixed block 71 is inside to be equipped with exhaust duct 75, threaded connection has connecting pipe 72 on fixed block 71, connecting pipe 72 passes through exhaust duct 75 and row material groove 74 internal connection, the contained angle is 30 degrees between exhaust duct 75 and the row material groove 74.

Specifically, fixed block 71 internal rotation is connected with rubber slab 77, rubber slab 77 is the trapezium structure, rubber slab 77 one side and row material groove 74 intercommunication, rubber slab 77 opposite side is contradicted with fixed block 71, it is connected with actuating lever 79 to rotate on the rubber slab 77, the internal sliding connection of fixed block 71 has slider 79a, actuating lever 79 rotates with slider 79a to be connected, the internal thread connection of slider 79a has lead screw 79b, lead screw 79b extends to fixed block 71 outside, fixedly connected with nut 73 on the lead screw 79b, lead screw 79b rotates with fixed block 71 to be connected, fixed block 71 is inside to be equipped with air guide groove 78, air exhaust groove 75 is through air guide groove 78 and rubber slab 77 one side intercommunication.

Specifically, the crushing mechanism 2 includes a fixed seat 21, the fixed seat 21 is installed on the furnace body 1, the fixed seat 21 is connected to an installation seat 23 in a clamping manner, a motor 25 is detachably connected to the installation seat 23, a movable groove 28 and a rotating shaft 26 are arranged inside the installation seat 23, the rotating shaft 26 is rotatably connected to the inside of the movable groove 28, the rotating shaft 26 is connected to the motor 25, a crushing cutter 27 is installed on the rotating shaft 26, the movable groove 28 is communicated with the inside of the furnace body 1, the installation seat 23 and the furnace body 1 are conveniently connected and installed under the action of the fixed seat 21, when wax materials are melted, the wax materials are firstly put into the movable groove 28, then a power supply is switched on to enable the motor 25 to work, and the motor 25 drives the crushing cutter 27 to rotate inside the movable groove 28, so that the wax materials are favorably crushed and flow into the furnace body 1 to be melted, and the efficiency of melting the wax materials is improved.

Specifically, be connected with two handles 24 on the mount pad 23, be connected with feeder hopper 22 on the mount pad 23, feeder hopper 22 and the inside intercommunication of

movable groove

28, 23 internally mounted of mount pad has screen cloth 29, movable groove 28 passes through screen cloth 29 and the inside intercommunication of smelting pot body 1, through it is convenient right under handle 24's the effect mount pad 23 and the separation of fixed seat 21, convenient subsequent maintenance cleaning work, simultaneously through feeder hopper 22 conveniently drops into the material the inside crushing work that carries on of movable groove 28, and pass through screen cloth 29 sieves, makes kibbling more even.

Specifically, the conveying mechanism 5 includes a screw rod 51, the screw rod 51 is rotatably connected to the inside of the fixing seat 21, the screw rod 51 extends to the inside of the furnace body 1, the screw rod 51 is connected with a first helical gear 52, the inside of the mounting seat 23 is rotatably connected with a connecting rod 54, the connecting rod 54 is provided with a second helical gear 53, the second helical gear 53 is vertically meshed with the first helical gear 52, the connecting rod 54 extends to the inside of the movable groove 28 and is connected with the rotating shaft 26 in a clamping manner, after the mounting seat 23 is clamped with the fixing seat 21, the connecting rod 54 can be connected with the rotating shaft 26 in a clamping manner, so that the rotating shaft 26 is driven to rotate the connecting rod 54, and the screw rod 51 is rotated at the bottom of the screen 29 through transmission of the second helical gear 53 and the first helical gear 52, so that the material falling from the screen 29 is guided out to the inside of the furnace body 1 through the screw rod 51 for melting work, thereby preventing material blockage and reducing efficiency.

Specifically, the joint of the rotating shaft 26 and the connecting rod 54 is a hexagonal prism structure, the diameter of the first bevel gear 52 is larger than that of the second bevel gear 53, so that the rotating shaft 26 and the connecting rod 54 can be clamped and connected to drive the connecting rod 54 to rotate through the rotating shaft 26, and meanwhile, the gear ratio of the second bevel gear 53 to the first bevel gear 52 has a large difference, so that the first bevel gear 52 can rotate slowly, the torsion is large, and the material can be conveyed well.

Specifically, cooling mechanism 3 includes aqua storage tank 33, the inside aqua storage tank 33 that is equipped with loop configuration of mount pad 23, be connected with two inlet tubes 31 and two outlet pipes 32 on the mount pad 23, the inside guide slot 34 that is equipped with of mount pad 23, inlet tube 31 passes through guide slot 34 and aqua storage tank 33 intercommunication, outlet pipe 32 and the inside intercommunication of aqua storage tank 33, through inlet tube 31 with outlet pipe 32 and external cooling machine's being connected to make cold water pass through inlet tube 31 with guide slot 34 carry extremely inside aqua storage tank 33, be favorable to work the motor 25 cools down the heat dissipation, and water after the cooling can pass through outlet pipe 32 discharges to realize the refrigerated work of circulation, prolonged motor 25's life.

Specifically, the inside two leather plugs 35 that are equipped with of mount pad 23, be connected with compression spring 36 on the leather plug 35, leather plug 35 passes through

compression spring

36 and 23 sliding connection of mount pad, inlet tube 31 and leather plug 35 top intercommunication, guide slot 34 and leather plug 35 lateral wall intercommunication, leather plug 35 is cylindrical structure, and when cold water passes through behind the inlet tube 31 gets into, cold water can extrude leather plug 35 gets rid of slide under compression spring 36's the effect, thereby make inlet tube 31 with guide slot 34 intercommunication, thereby make cold water get into inside the aqua storage tank 33, damage the messenger when water pressure undersize or cooler, make leather plug 35 is in reset under compression spring 36's the effect, thereby to guide slot 34 blocks up, makes the inside water of aqua storage tank 33 can not flow back, makes simultaneously inside the dry and withered influence can not cause the motor 25 heat dissipation.

Specifically, blocked mechanical system 4 includes bayonet lock 42, the inside bayonet lock 42 that is equipped with two symmetries of mount pad 23, be connected with reset spring 44 on the bayonet lock 42, bayonet lock 42 passes through

reset spring

44 and 23 sliding connection of mount pad, be equipped with two draw-in grooves 43 on the fixing base 21, bayonet lock 42 runs through in mount pad 23 and the inside block of draw-in groove 43, be connected with depression bar 41 on the bayonet lock 42, depression bar 41 extends to the mount pad 23 outside, depression bar 41 passes through

bayonet lock

42 and 23 sliding connection of mount pad, works as mount pad 23 with behind the fixing base 21 block, bayonet lock 42 is in the effect of reset spring 44 down with the inside block of draw-in groove 43, thereby make mount pad 23 with the spacing difficult separation of fixing base 21, when pressing depression bar 41 makes depression bar 41 drives bayonet lock 42 breaks away from under reset spring's the effect with the inside separation of draw-in groove 43, thereby pass through handle 24 is convenient right mount pad 23 with the fixing base 21 separation.

Specifically, bayonet lock 42 is "L" shape structure, bayonet lock 42 bottom one end is the triangle-shaped structure, is connected with clamp plate 45 on the depression bar 41, clamp plate 45 is oval structure, is favorable to making bayonet lock 42 can be contradicted the shrink, and slide into at last the inside conflict of draw-in groove 43 is spacing, through convenient right under the effect of clamp plate 45 depression bar 41 extrusion drive makes the operation hand more comfortable.

Specifically, the protection machanism 6 includes slide bar 61, two be connected with slide bar 61 on the leather plug 35, slide bar 61 runs through in compression spring 36 and the inside sliding connection of mount pad 23, be equipped with logical groove 62 on the slide bar 61, be connected with ejector pin 63 on the bayonet lock 42, ejector pin 63 and mount pad 23 sliding connection, ejector pin 63 and logical groove 62 intercommunication, ejector pin 63 width and thickness are less than logical groove 62 inside width and thickness, through bayonet lock 42's slip, thereby drive ejector pin 63 is in logical groove 62 inside slides, works as behind the leather plug 35 receives the water pressure gliding, make slide bar 61 gliding, thereby make logical groove 62 slide to the mount pad 23 inside and hide, work as when bayonet lock 42 needs to slide, ejector pin 63 can with slide bar 61 lateral wall is contradicted, thereby makes bayonet lock 42 is difficult to be slided, makes in the cooling process bayonet lock 42 is difficult to be driven, prevents mount pad 23 with fixing base 21 separates, thereby has played the effect of protection.

Specifically, referring to fig. 10, fig. 10 is a flow chart of the detection method of the manufacturing equipment for melt-preparing the diclofenac sodium sustained-release composition provided by the present invention, and the detection method of the manufacturing equipment for melt-preparing the diclofenac sodium sustained-release composition comprises the following steps:

s1: firstly, crushing a large waxy material under the action of a crushing mechanism 2;

s2: the conveying mechanism 5 is driven to operate through the operation of the crushing mechanism 2, and the materials crushed by the crushing mechanism 2 are conveyed under the action of the conveying mechanism 5, so that the materials are introduced into the smelting furnace body 1;

s3: when the crushing mechanism 2 works, the crushing mechanism 2 is subjected to circulating water heat dissipation and cooling under the action of the cooling mechanism 3, and the crushing mechanism 2 is subsequently detachably mounted and separated under the action of the locking mechanism 4;

s4: melting waxy material to obtain melt, conveying and discharging the melt into the fluidized bed under the action of a discharge mechanism 7, mixing diclofenac sodium and hydrophilic material in the fluidized bed to form a mixture, spraying the melt into the fluidized bed, mixing the melt with the mixture for granulation, and cooling to obtain the diclofenac sodium sustained-release composition, wherein the capsule filling equipment is a pellet capsule filling machine.

When the invention is used, firstly, the mounting seat 23 and the furnace body 1 are conveniently connected and mounted under the action of the fixed seat 21, when wax materials are melted, firstly, the wax materials are thrown into the movable groove 28, then, a power supply is switched on to enable the motor 25 to work, and the motor 25 drives the crushing cutter 27 to rotate in the movable groove 28, so that the wax materials are crushed and flow into the furnace body 1 for melting work, thereby improving the melting efficiency of the wax materials, the mounting seat 23 and the fixed seat 21 are conveniently separated under the action of the handle 24, the subsequent cleaning work is convenient, meanwhile, the materials are conveniently thrown into the movable groove 28 for crushing work through the feed hopper 22, and are screened through the screen 29, so that the crushing is more uniform, after the mounting seat 23 is clamped with the fixed seat 21, the connecting rod 54 is clamped and connected with the rotating shaft 26, so that the connecting rod 54 is driven to rotate when the rotating shaft 26, and the helical gear 53 and the first helical gear 52 are driven through the transmission of the second helical gear 53 and the first helical gear 52, so that the helical gear 51 rotates at the bottom of the screen 29, the material is beneficial to guide the material out of the helical gear 51 to the furnace body 1 through the helical gear 51, thereby being capable of guiding the material out through the helical gear 51, the helical gear 21, the helical gear 32, thereby being favorable for preventing the cooling water inlet pipe 32 and reducing the water inlet pipe 32, and reducing the water temperature of the water outlet pipe, and reducing the water inlet pipe 32, and reducing the water temperature of the water cooling water, and reducing the water inlet pipe 32, thereby realizing the work of circulating cooling, prolonging the service life of the motor 25, when cold water enters through the water inlet pipe 31, the cold water can extrude the leather plug 35 to slide under the action of getting rid of the compression spring 36, thereby leading the water inlet pipe 31 to be communicated with the guide groove 34, thereby leading the cold water to enter the water storage groove 33, when the water pressure is too low or the cooling machine is damaged, leading the leather plug 35 to reset under the action of the compression spring 36, thereby blocking the guide groove 34, leading the water in the water storage groove 33 not to flow back, simultaneously leading the water storage groove 33 not to cause withering influence to radiate the heat of the motor 25, when the mounting seat 23 is clamped with the fixed seat 21, the bayonet pin 42 is clamped with the inside of the bayonet groove 43 under the action of the reset spring 44, thereby leading the mounting seat 23 and the fixed seat 21 to be limited and not easy to separate, when the press rod 41 is pressed, leading the press rod 41 to drive the bayonet pin 42 to get rid of getting rid of the inside of the reset spring 44 to separate from the bayonet groove 43, thereby facilitating the separation of the mounting seat 23 and the fixed seat 21 through the handle 24, the clamping pin 42 can be abutted and contracted and finally slides into the clamping groove 43 to be abutted and limited, the pressing plate 45 is used for conveniently extruding and driving the pressing rod 41, so that the hand is more comfortable to operate, the ejecting rod 63 is driven to slide in the through groove 62 by the sliding of the clamping pin 42, the sliding rod 61 slides down after the leather plug 35 slides down under the water pressure, the through groove 62 slides to the inside of the mounting seat 23 to be hidden, when the clamping pin 42 needs to slide, the ejecting rod 63 can abut against the side wall of the sliding rod 61, so that the clamping pin 42 is not easy to slide, the clamping pin 42 is not easy to be driven in the cooling process, the mounting seat 23 is prevented from being separated from the fixing seat 21, the protective effect is achieved, a molten wax material is obtained after being molten, the molten material is connected with one end of the fixing block 71 through an external pipeline, the material in the smelting furnace body 1 can be conveyed to the inside of the external pipeline through the discharging groove 74, meanwhile, by connecting the connecting pipe 72, external air enters the exhaust groove 75 through the connecting pipe 72, and the exhaust groove 75 is used for pressurizing and blowing air into the interior of the discharge groove 74, so that the material in the interior of the discharge groove 74 is conveyed quickly and is not easy to block, the discharged material is conveyed smoothly and is not easy to flow back under the action of the plurality of guide plates 76, the screw rod 79b is driven to the slide block 79a under the action of threads by rotating the screw cap 73, the slide block 79a can slide downwards against the driving rod 79, so that the rubber plate 77 is pressed to rotate, after the rubber plate 77 rotates to a certain position, the air in the interior of the exhaust groove 75 enters one side of the rubber plate 77 through the air guide groove 78, the discharge groove 74 and the interior of the furnace body 1 are blown up through the rubber plate 77, so that the material accumulated at the opening of the furnace body 1 is discharged, the material blocking is prevented from entering the interior of the discharge groove 74 to be conveyed, when the screw cap 73 is rotated reversely, the slide block 79a pulls the rubber plate to rotate, the material is prevented from being discharged from the opening of the furnace body 1, the discharge groove, the diclofenac sodium mixing and the molten material is conveniently sprayed into the fluidized bed, and the diclofenac capsule mixing and the fluidized bed, and the diclofenac sodium capsule is conveniently discharged, and the diclofenac sodium mixing and the fluidized bed, and the diclofenac capsule filling device, and the diclofenac capsule is formed in the fluidized bed.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The preparation equipment for preparing the diclofenac sodium slow-release composition in a melting mode is characterized by comprising a melting furnace body (1), wherein a crushing mechanism (2) is installed on the melting furnace body (1), a conveying mechanism (5) is installed inside the crushing mechanism (2), a cooling mechanism (3) is arranged inside the crushing mechanism (2), two locking mechanisms (4) are installed inside the crushing mechanism (2), a protection mechanism (6) is connected inside the crushing mechanism (2), and a discharging mechanism (7) is connected to the melting furnace body (1); the discharging mechanism (7) comprises a fixed block (71), the fixed block (71) is detachably connected onto the smelting furnace body (1), a discharging groove (74) is formed in the fixed block (71), a plurality of guide plates (76) which are equidistantly and symmetrically distributed are arranged in the discharging groove (74), the smelting furnace body (1) is connected with the outside through the discharging groove (74), an exhaust groove (75) is formed in the fixed block (71), a connecting pipe (72) is connected onto the fixed block (71) in a threaded manner, the connecting pipe (72) is connected with the inside of the discharging groove (74) through the exhaust groove (75), and an included angle between the exhaust groove (75) and the discharging groove (74) is 30 degrees; the rubber plate (77) is connected to the inside of the fixed block (71) in a rotating mode, the rubber plate (77) is of a trapezoidal structure, one side of the rubber plate (77) is communicated with a discharging groove (74), the other side of the rubber plate (77) is abutted to the fixed block (71), a driving rod (79) is connected to the rubber plate (77) in a rotating mode, a sliding block (79 a) is connected to the inside of the fixed block (71) in a sliding mode, the driving rod (79) is connected with the sliding block (79 a) in a rotating mode, a lead screw (79 b) is connected to the inside of the sliding block (79 a) in a threaded mode, the lead screw (79 b) extends to the outside of the fixed block (71), a nut (73) is fixedly connected to the lead screw (79 b), the lead screw (79 b) is connected with the fixed block (71) in a rotating mode, an air guide groove (78) is arranged inside the fixed block (71), and the air exhaust groove (75) is communicated with one side of the rubber plate (77) through the air guide groove (78);

the crushing mechanism (2) comprises a fixed seat (21), the fixed seat (21) is installed on the smelting furnace body (1), an installation seat (23) is connected to the fixed seat (21) in a clamping mode, a motor (25) is detachably connected to the installation seat (23), a movable groove (28) and a rotating shaft (26) are arranged inside the installation seat (23), the rotating shaft (26) is rotatably connected with the inside of the movable groove (28), the rotating shaft (26) is connected with the motor (25), a crushing cutter (27) is installed on the rotating shaft (26), the movable groove (28) is communicated with the inside of the smelting furnace body (1), two handles (24) are connected to the installation seat (23), a feeding hopper (22) is connected to the installation seat (23), the feeding hopper (22) is communicated with the inside of the movable groove (28), a screen (29) is installed inside the installation seat (23), and the movable groove (28) is communicated with the inside of the smelting furnace body (1) through the screen (29);

the conveying mechanism (5) comprises a screw rod (51), the screw rod (51) is rotatably connected to the inside of the fixed seat (21), the screw rod (51) extends to the inside of the furnace body (1), a first helical gear (52) is connected to the screw rod (51), a connecting rod (54) is rotatably connected to the inside of the mounting seat (23), a second helical gear (53) is mounted on the connecting rod (54), the second helical gear (53) is vertically meshed with the first helical gear (52), the connecting rod (54) extends to the inside of the movable groove (28) and is connected with the rotating shaft (26) in a clamping manner, the joint of the rotating shaft (26) and the connecting rod (54) is of a hexagonal structure, and the diameter of the first helical gear (52) is larger than that of the second helical gear (53);

the cooling mechanism (3) comprises a water storage tank (33), the water storage tank (33) with an annular structure is arranged in the mounting seat (23), two water inlet pipes (31) and two water outlet pipes (32) are connected to the mounting seat (23), a guide groove (34) is arranged in the mounting seat (23), the water inlet pipes (31) are communicated with the water storage tank (33) through the guide groove (34), and the water outlet pipes (32) are communicated with the inside of the water storage tank (33);

two leather plugs (35) are arranged in the mounting seat (23), a compression spring (36) is connected to each leather plug (35), the leather plugs (35) are connected with the mounting seat (23) in a sliding mode through the compression springs (36), the water inlet pipe (31) is communicated with the tops of the leather plugs (35), the guide groove (34) is communicated with the side walls of the leather plugs (35), and the leather plugs (35) are of cylindrical structures;

the locking mechanism (4) comprises a bayonet lock (42), two symmetrical bayonet locks (42) are arranged in the mounting seat (23), a reset spring (44) is connected to each bayonet lock (42), each bayonet lock (42) is connected with the mounting seat (23) in a sliding mode through the reset spring (44), two clamping grooves (43) are formed in the fixing seat (21), each bayonet lock (42) penetrates through the mounting seat (23) and the clamping groove (43) to be clamped in the inside, a pressing rod (41) is connected to each bayonet lock (42), each pressing rod (41) extends to the outside of the mounting seat (23), and each pressing rod (41) is connected with the mounting seat (23) in a sliding mode through the bayonet lock (42);

the clamping pin (42) is of an L-shaped structure, one end of the bottom of the clamping pin (42) is of a triangular structure, the pressing rod (41) is connected with a pressing plate (45), and the pressing plate (45) is of an oval structure;

protection machanism (6) include slide bar (61), two be connected with slide bar (61) on leather plug (35), slide bar (61) run through in compression spring (36) and mount pad (23) inside sliding connection, be equipped with logical groove (62) on slide bar (61), be connected with ejector pin (63) on bayonet lock (42), ejector pin (63) and mount pad (23) sliding connection, ejector pin (63) and logical groove (62) intercommunication, ejector pin (63) width and thickness are less than logical groove (62) inside width and thickness.

2. The process for preparing a diclofenac sodium sustained release composition by melting according to claim 1, characterized in that: the method comprises the following steps:

s1: firstly, crushing a large waxy material under the action of a crushing mechanism (2);

s2: the conveying mechanism (5) is driven to operate through the work of the crushing mechanism (2), and the materials crushed by the crushing mechanism (2) are conveyed under the action of the conveying mechanism (5) so as to be guided into the smelting furnace body (1);

s3: when the crushing mechanism (2) works, the crushing mechanism (2) is subjected to circulating water heat dissipation and cooling under the action of the cooling mechanism (3), and the crushing mechanism (2) is subsequently detachably mounted and separated under the action of the locking mechanism (4);

s4: melting waxy materials to obtain a melt, conveying and discharging the melt to the interior of a fluidized bed under the action of a discharging mechanism (7), mixing diclofenac sodium and hydrophilic materials in the fluidized bed to form a mixture, spraying the melt into the fluidized bed to be mixed with the mixture for granulation, and then cooling to obtain the diclofenac sodium sustained-release composition, wherein the capsule filling equipment is a pellet capsule filling machine.