CN113729855A - Insertion type combined ultrasonic thrombolysis device - Google Patents
Insertion type combined ultrasonic thrombolysis device Download PDFInfo
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Abstract
The utility model provides an intervention formula combination supersound thrombolysis device, including outer pipe, the inner catheter, preceding ultrasonic transducer, side direction ultrasonic transducer and signal of telecommunication transmission line, the inner catheter locate in the outer pipe and with form the clearance between the outer pipe, the lateral wall of outer pipe is equipped with the inhale tie hole with the clearance intercommunication, preceding ultrasonic transducer locates the front end of outer pipe and is used for the front end transmission ultrasonic wave towards the outer pipe, preceding ultrasonic transducer is equipped with the through-hole that switches on with the inner catheter, side direction ultrasonic transducer locates the lateral wall of outer pipe and is used for the side direction transmission ultrasonic wave towards the outer pipe, preceding ultrasonic transducer and side direction ultrasonic transducer all with signal of telecommunication transmission line electric connection, signal of telecommunication transmission line is used for applying the signal of telecommunication to preceding ultrasonic transducer and side direction ultrasonic transducer. The thrombus dissolving device has the advantages of high thrombus dissolving efficiency, thorough thrombus removal, small injury to blood vessels, strong applicability to thrombus types and the like, and particularly has better effect on completely blocked or seriously blocked thrombus and old contracted thrombus.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an interventional combined ultrasonic thrombolysis device.
Background
The formation of thrombus often causes the occlusion of peripheral blood vessels, seriously causes dangerous diseases such as ischemic stroke, myocardial infarction, pulmonary embolism and the like, and seriously harms the life health of human beings. The traditional methods of drug thrombolysis, balloon interventional angioplasty or surgical thrombus removal all have obvious defects, the injury of a patient caused by the surgical thrombus removal is large, the time window of drug thrombolysis is short, the success rate is not high, and complications such as nerve injury, tissue internal bleeding and the like can be caused frequently. Research shows that the ultrasonic-assisted thrombolysis is an effective thrombolysis method, has the characteristics of high thrombolysis efficiency and good safety, can remarkably reduce the dosage of thrombolytic drugs, greatly reduces the risk of complications such as tissue internal hemorrhage, nervous injury and the like, and shows attractive application prospects.
An interventional ultrasonic thrombolysis method combining a microbubble contrast agent and a thrombolysis medicine is a new thrombolysis technology proposed in recent years, cavitation effect generated by ultrasonic waves and self mechanical vibration promote the thrombus to be cracked, and action targets of the thrombolysis medicine are increased, so that thrombolysis is accelerated. In order to better match the use of microbubble contrast agents and thrombolytic drugs, the prior art provides an interventional ultrasonic thrombolysis device which transmits ultrasonic waves forwards along the axial direction of a catheter, the device can work without an ultrasonic thrombolysis probe entering the interior of a thrombus, the thrombolysis probe is guided to a position 1mm away from the end of the thrombus to transmit the ultrasonic waves, and the effective thrombolysis is facilitated through the combined action of ultrasonic cavitation effect and thrombolytic drugs. The method has better thrombolytic effect on completely blocked thrombus or some thrombus with serious occlusion. However, for some old contracted thrombi, the tissues are hard and firmly adhered to the vascular wall, the ultrasonic waves emitted forwards along the axial direction of the catheter have good thrombolysis effect on the middle part in the blood vessel, and the effect on the thrombi close to the vascular wall is weak, so that the aim of completely dissolving the thrombi cannot be achieved. At present, the research and development of an intervention type ultrasonic thrombolysis device with high thrombolysis efficiency, thorough thrombolysis and wide applicability is urgently needed.
Disclosure of Invention
In order to overcome the defects and shortcomings in the prior art, the invention aims to provide an intervention type combined ultrasonic thrombolysis device to solve the problem that the ultrasonic thrombolysis device in the prior art is poor in thrombolysis effect.
The purpose of the invention is realized by the following technical scheme:
the invention provides an interventional combined ultrasonic thrombolysis device, which comprises an outer catheter, an inner catheter, a forward ultrasonic transducer, a lateral ultrasonic transducer and an electric signal transmission line, the inner catheter is arranged in the outer catheter and forms a gap with the outer catheter, the side wall of the outer catheter is provided with a suction plug hole communicated with the gap, the forward ultrasonic transducer is provided at the front end of the outer catheter and is used for emitting ultrasonic waves toward the front end of the outer catheter, the forward ultrasonic transducer is provided with a through hole communicated with the inner catheter, the lateral ultrasonic transducer is arranged on the outer side wall of the outer catheter and used for emitting ultrasonic waves towards the lateral side of the outer catheter, the forward ultrasonic transducer and the lateral ultrasonic transducer are both electrically connected with the electric signal transmission line, the electrical signal transmission line is used for applying electrical signals to the forward ultrasonic transducer and the lateral ultrasonic transducer.
Further, the forward ultrasonic transducer comprises a plurality of piezoelectric ceramic plates stacked on each other, the polarization directions of the piezoelectric ceramic plates are parallel to the axial direction of the outer catheter, and the polarization directions of two adjacent piezoelectric ceramic plates are opposite.
Furthermore, the thickness of the single piezoelectric ceramic piece is 0.1-0.25 mm, and the two adjacent piezoelectric ceramic pieces are bonded together through conductive adhesive.
Further, an edge of the forward ultrasound transducer does not extend beyond an outer side of the outer catheter.
Furthermore, the front end of the forward ultrasonic transducer is provided with an acoustic matching layer, and the thickness of the acoustic matching layer is 0.5-1 mm.
Further, the lateral ultrasonic transducer comprises a plurality of piezoelectric ceramic rings arranged at intervals, the piezoelectric ceramic rings are arranged around the side wall of the outer guide pipe, and the polarization direction of the piezoelectric ceramic rings is perpendicular to the axial direction of the outer guide pipe.
Further, the distance between every two adjacent piezoelectric ceramic rings is 1-2 mm.
Further, the lateral ultrasonic transducer is arranged on the outer side wall of the outer catheter, and the outer side face of the lateral ultrasonic transducer is flush with the outer side face of the outer catheter.
Further, the suction bolt hole is arranged between the front ultrasonic transducer and the side ultrasonic transducer.
Furthermore, the number of the suction plug holes is multiple and is arranged along the circumferential direction or the axial direction of the outer conduit, and the suction plug holes are of a circular or oval structure.
Further, the inner catheter penetrates out of the side wall of the outer catheter at the end far away from the forward ultrasonic transducer, and is branched and forms a Y-shaped double-pass tube.
Further, the electrical signal transmission line is disposed in a wall of the outer catheter.
Furthermore, the interventional combined ultrasonic thrombolysis device further comprises a change-over switch and an ultrasonic signal generator, and one end of the electric signal transmission line, which is far away from the forward ultrasonic transducer and the lateral ultrasonic transducer, is electrically connected with the ultrasonic signal generator through the change-over switch.
The invention has the beneficial effects that: launch the ultrasonic wave forward through preceding ultrasonic transducer for clear away the thrombus at blood vessel center, make supersound thrombolysis probe can stretch into the thrombus inside, rethread side direction ultrasonic transducer is to the side transmission ultrasonic wave, be used for clearing away the thrombus of blood vessel lateral wall, in order to detach the hard, firm thrombus with the vascular wall adhesion of texture. And can also inject thrombolysis medicine and microbubble contrast medium to the thrombus department through the inner catheter, can accelerate the clearance to the thrombus, the thrombolysis medicine jets out through the through-hole on the preceding ultrasonic transducer to the accurate thrombus of aiming at carries out the medicine, can significantly reduce the use dose of thrombolysis medicine, greatly reduced the risk that takes place complications such as internal hemorrhage of tissue, nerve injury. The thrombolysis device has the advantages of high thrombolysis efficiency, thorough thrombus removal, small damage to blood vessels, strong applicability to thrombus types and the like, can obtain good effects on complete and partial blocking type thrombus, and particularly has good technical advantages on complete blocking, serious blocking and old contraction type thrombus.
Drawings
FIG. 1 is a schematic structural diagram of an interventional combined ultrasonic thrombolysis device according to the present invention;
FIG. 2 is a schematic cross-sectional view of the front end of the interventional combined ultrasonic thrombolysis device according to the present invention;
fig. 3 is a schematic cross-sectional structure of the forward ultrasonic transducer of the present invention.
In the figure: the ultrasonic thrombolysis probe comprises an outer catheter 1, a thrombus absorption hole 2, an electric signal transmission line 3, an inner catheter 4, an ultrasonic thrombolysis probe 5, a forward ultrasonic transducer 6, a lateral ultrasonic transducer 7, a change-over switch 8, an ultrasonic signal generator 9 and an injector 10.
Detailed Description
To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the following detailed description of the embodiments, structures, features and effects of the intervention type combined ultrasonic thrombolysis device according to the present invention with reference to the accompanying drawings and preferred embodiments is as follows:
as shown in fig. 1 to 3, the interventional combined ultrasonic thrombolysis device provided by the invention comprises an outer catheter 1, an inner catheter 4, a forward ultrasonic transducer 6, a lateral ultrasonic transducer 7 and an electrical signal transmission line 3, wherein the inner catheter 4 is arranged in the outer catheter 1 and forms a gap with the outer catheter 1, the side wall of the outer catheter 1 is provided with a thrombus suction hole 2 communicated with the gap, and dropped thrombus is sucked through the suction hole 2 and is drained out from the gap between the inner catheter 4 and the outer catheter 1. The forward ultrasonic transducer 6 is arranged at the front end of the outer catheter 1 and used for emitting ultrasonic waves towards the front end of the outer catheter 1, the forward ultrasonic transducer 6 is provided with a through hole communicated with the inner catheter 4, the inner diameter of the through hole is the same as the outer diameter of the inner catheter 4 and is 0.5-0.9 mm, and thrombolytic drugs and microbubble contrast agents are conveyed through the inner catheter 4 or a guide wire is inserted into the through hole and exposed out of the through hole of the forward ultrasonic transducer 6. The lateral ultrasonic transducer 7 is provided on the outer side wall of the outer catheter 1 and serves to emit ultrasonic waves toward the lateral side of the outer catheter 1. The forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 are both electrically connected with the electric signal transmission line 3, the electric signal transmission line 3 is used for applying electric signals to the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7, and the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 form an ultrasonic thrombolysis probe 5. Wherein, the front end is the end close to the thrombus, for example, the front end of the outer catheter 1 is the end close to the thrombus after the outer catheter 1 extends into the blood vessel; the lateral direction is the direction perpendicular to the axis of the outer catheter 1.
In this embodiment, the forward ultrasonic transducer 6 includes a plurality of piezoelectric ceramic plates stacked on each other, and the polarization direction of the piezoelectric ceramic plates is parallel to the axial direction of the outer catheter 1, so that the piezoelectric ceramic plates can emit ultrasonic waves toward the front end of the outer catheter 1. Preferably, the number of the piezoelectric ceramic pieces is 6, and the thickness of each piezoelectric ceramic piece is 0.1-0.25 mm, so that the piezoelectric ultrasonic transducer can generate larger vibration displacement and emit larger energy of ultrasonic waves. Of course, the number and thickness of the piezoelectric ceramic plates can be adjusted according to actual conditions. The shape of the piezoelectric ceramic piece is circular or square, wherein the diameter of the circular section is 1-2.7 mm, the side length of the square section is 1-2 mm, and the size of the piezoelectric ceramic piece is smaller than or equal to the diameter of the outer catheter 1, so that the edge of the forward ultrasonic transducer 6 does not exceed the outer side surface of the outer catheter 1. The forward ultrasonic transducer 6 can be arranged in the outer catheter 1, the outer side wall of the forward ultrasonic transducer 6 is connected with the inner side wall of the outer catheter 1, of course, the size of the forward ultrasonic transducer 6 can be equal to the diameter of the outer catheter 1, and the forward ultrasonic transducer 6 is connected with the foremost end of the side wall of the outer catheter 1.
Further, as shown in fig. 3, the arrows indicate the polarization direction of the piezoelectric ceramic sheet. The polarization directions of two adjacent piezoelectric ceramic pieces are opposite, and the two adjacent piezoelectric ceramic pieces are bonded together through conductive adhesive. For example, two adjacent piezoelectric ceramic pieces are adhered together through conductive epoxy resin, and one sides of the same electrodes of the two adjacent piezoelectric ceramic pieces are arranged oppositely, so that an electric signal can be applied to the same electrodes of the two adjacent piezoelectric ceramic pieces through one lead, and the number of leads and the size of a thrombolysis device are reduced. The positive electrodes and the negative electrodes of the piezoelectric ceramic plates are respectively connected and then led out through the electric signal transmission line 3, and then insulation sealing is carried out.
Furthermore, an acoustic matching layer is arranged at the front end of the forward ultrasonic transducer 6, and the thickness of the acoustic matching layer is 0.5-1 mm. The acoustic matching layer is arranged so that the ultrasonic waves generated by the forward ultrasonic transducer 6 can effectively act on the thrombus, and the ultrasonic energy loss is avoided. Of course, the acoustic matching layer cannot cover the through hole of the forward ultrasound transducer 6, and thus the inner catheter 4 is prevented from being influenced to deliver thrombolytic drugs and microbubble contrast agents or to be inserted into a guide wire.
Further, the lateral ultrasonic transducer 7 includes a plurality of piezoelectric ceramic rings disposed at intervals, the piezoelectric ceramic rings are disposed around the side wall of the outer catheter 1, and the polarization direction of the piezoelectric ceramic rings is perpendicular to the axial direction of the outer catheter 1, so that the piezoelectric ceramic rings can emit ultrasonic waves toward the lateral direction of the outer catheter 1. The energy of ultrasonic waves and the irradiation range of the ultrasonic waves can be improved by arranging the piezoelectric ceramic rings, and the more the quantity is, the stronger the ultrasonic energy is, and the wider the irradiation range is. Preferably, the distance between the lateral ultrasonic transducer 7 and the forward ultrasonic transducer 6 is 3-5 mm, so that the suction bolt hole 2 is conveniently formed between the lateral ultrasonic transducer 7 and the forward ultrasonic transducer 6. The number of the piezoelectric ceramic rings is 3, the distance between every two adjacent piezoelectric ceramic rings is 1-2 mm, the energy of the piezoelectric ceramic rings is concentrated in the distance range, and the manufacturing process is easy to realize, wherein the smaller the distance between the piezoelectric ceramic rings is, the more concentrated the energy is, but the difficulty of the manufacturing process is increased; the positive electrodes and the negative electrodes of the piezoelectric ceramic rings are respectively connected and then led out through an electric signal transmission line 3. In other embodiments, the lateral ultrasound transducer 7 may also be composed of a plurality of piezo ceramic blocks annularly distributed on the sidewall of the outer catheter 1. Of course, the side of the lateral ultrasonic transducer 7 may also be provided with an acoustic matching layer, so that the ultrasonic waves generated by the lateral ultrasonic transducer 7 can effectively act on the thrombus on the side wall of the blood vessel, and the ultrasonic energy loss is avoided.
Further, the lateral ultrasonic transducer 7 is arranged on the outer side wall of the outer catheter 1, and the outer side surface of the lateral ultrasonic transducer 7 is flush with the outer side surface of the outer catheter 1. Preferably, the outer surface of the outer catheter 1 is provided with a mounting groove matched with the lateral ultrasonic transducer 7, the piezoelectric ceramic rings are mounted on the outer surface of the outer catheter 1 in a nesting or bonding mode and are guaranteed to be firmly fixed, and the outer diameter of the lateral ultrasonic transducer 7 is consistent with that of the outer catheter 1 in size, so that the inner wall of a blood vessel cannot be damaged in the process of inserting the outer catheter 1 into the blood vessel. Of course, in other embodiments, the lateral ultrasonic transducer 7 may also be disposed in the wall of the outer catheter 1, that is, when the wall of the outer catheter 1 is manufactured, the lateral ultrasonic transducer 7 is wrapped in the wall material of the outer catheter 1.
The piezoelectric materials adopted by the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 are piezoelectric ceramics PZT-5A, and in practical application, suitable piezoelectric materials can be selected according to requirements, including but not limited to PZT-4, PZT-8 and other piezoelectric materials with high mechanical quality factors. In this embodiment, the piezoelectric ceramic plate is made of a piezoelectric ceramic material and has a sheet structure, and the piezoelectric ceramic ring is made of a piezoelectric ceramic material and has an annular structure. Piezoelectric ceramics are a class of electronic ceramic materials having piezoelectric properties. The main differences from a typical piezoelectric quartz crystal that does not contain a ferroelectric component are: the crystal phases constituting the main components are all ferroelectric crystal grains. Since the ceramic is a polycrystalline aggregate in which the crystal grains are randomly oriented, the spontaneous polarization vectors of the individual ferroelectric crystal grains therein are also disorderly oriented. In order to make the ceramics exhibit macroscopic piezoelectric characteristics, it is necessary to perform a polarization treatment in which the piezoelectric ceramics are fired, the end faces are covered with electrodes, and then the piezoelectric ceramics are subjected to a strong direct current electric field so that the respective polarization vectors of the original disordered orientations are preferentially oriented in the direction of the electric field. After the electric field is cancelled, the piezoelectric ceramic after polarization treatment can retain a certain macroscopic remanent polarization strength, so that the ceramic has a certain piezoelectric property. For a more detailed description of the piezoelectric ceramics, reference may be made to the prior art, which is not described in detail here.
Preferably, the working frequency range of the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 is 200-800 kHz. In practical application, however, the operating frequencies of the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 can be adjusted as required to achieve the best thrombolysis effect.
In this embodiment, the thrombus absorption hole 2 is arranged between the front ultrasonic transducer 6 and the side ultrasonic transducer 7, and thrombus can be extracted in time through the thrombus absorption hole 2 after being ultrasonically cracked by the front ultrasonic transducer 6 and the side ultrasonic transducer 7, and then the thrombus is transported out through a gap between the outer catheter 1 and the inner catheter 4. The number of the suction plug holes 2 is a plurality and is arranged along the circumferential direction or the axial direction of the outer catheter 1, and the suction plug holes 2 are in a circular or oval structure. Preferably, the number of the thrombus holes 2 is two and the thrombus holes are arranged along the circumferential direction of the outer catheter 1, the thrombus holes 2 are of an oval structure, the short radius of the oval is 0.5-1 mm, and the long radius of the oval is 1-2 mm, so that irregular thrombus can be sucked out more easily. Of course, in other embodiments, the suction plug hole 2 may be provided at the rear end of the lateral ultrasonic transducer 7, and the lateral ultrasonic transducer 7 is provided between the suction plug hole 2 and the forward ultrasonic transducer 6. Or the front end and the rear end of the lateral ultrasonic transducer 7 are both provided with the suction bolt holes 2.
Further, as shown in fig. 1, the inner catheter 4 is passed out from the side wall of the outer catheter 1 at the end remote from the forward ultrasonic transducer 6, and is bifurcated and formed into a "Y" shaped double-pass tube. Namely, the front end of the inner catheter 4 is sleeved on the through hole of the forward ultrasonic transducer 6, the tail end of the inner catheter 4 is positioned outside the body and is arranged as a Y-shaped double-way catheter, and the two separated catheters are both connected with the injector 10 and are respectively used for injecting thrombolytic drugs and microbubble contrast agents. Of course, the inner catheter 4 can also be used for inserting a guide wire during the insertion of the catheter (outer catheter 1, inner catheter 4) into the blood vessel, so as to guide the sonothrombolysis probe to the thrombus site.
In this embodiment, the electrical signal transmission line 3 is disposed in the wall of the outer catheter 1, that is, when the wall of the outer catheter 1 is manufactured, the electrical signal transmission line 3 is wrapped in the wall material of the outer catheter 1. Of course, the electrical signal transmission line 3 may be provided on the inner side wall of the outer catheter 1, but may affect the expulsion of thrombus.
Further, one end (tail end) of the outer catheter 1 positioned outside the body is connected with a suction pump and is used for extracting the micro-plaque after thrombolysis. Preferably, the length of the outer catheter 1 is 90-110 mm, so that the outer catheter 1 can be better operated to extend into the blood vessel.
Furthermore, the interventional combined ultrasonic thrombolysis device further comprises a change-over switch 8 and an ultrasonic signal generator 9, and one end of the electric signal transmission line 3, which is far away from the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7, is electrically connected with the ultrasonic signal generator 9 through the change-over switch 8. The forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 are connected to the same ultrasonic signal generator 9 through a change-over switch 8, and the ultrasonic transducers to be used are controlled to work independently through the change-over switch 8. In practical application, the two ultrasonic transducers can be respectively connected with the two ultrasonic signal generators 9 according to the size, the type and the like of thrombus, so that the two ultrasonic transducers can work simultaneously according to the requirement, and the optimal thrombolytic effect is achieved. The ultrasonic signal generator 9 comprises a signal generator, a signal amplifier, a switch and an ultrasonic transducer joint, the switch is used for starting the ultrasonic signal generator 9 to generate a driving signal, and the driving signal is amplified by the signal amplifier, so that the ultrasonic transducer is driven to emit ultrasonic waves.
In this embodiment, a completely blocked thrombus is taken as an example of a thrombolytic object, and the main steps of performing intravascular thrombolysis by using the interventional combined ultrasonic thrombolysis device provided by the invention are as follows:
the method comprises the following steps: introducing a guide wire through a blood vessel to enable the guide wire to reach the position of thrombus; guiding and intervening a catheter and an ultrasonic thrombolysis probe 5 through a guide wire, injecting a microbubble contrast agent through an inner catheter 4, and determining the position of thrombus; then, the forward ultrasonic transducer 6 is inserted into the end part of the thrombus, and the guide wire is pulled out; thereafter, the thrombolytic drug is injected through the inner catheter 4.
Step two: the ultrasonic signal generator 9 is started, the forward ultrasonic transducer 6 is driven to emit ultrasonic waves, ultrasonic waves in the forward direction along the axis of the catheter are applied to the end part of the thrombus, cavitation effect is generated to promote the thrombus to be cracked, thrombolytic drugs are promoted to further permeate into the thrombus, the action target point of the thrombolytic drugs is increased, and the thrombus dissolution is promoted.
Step three: after the second step is completed, the middle part of the thrombus is effectively dissolved initially. At this time, the catheter and the ultrasonic thrombolysis probe 5 are further advanced into the inside of the thrombus; then, the ultrasonic signal generator 9 is started to drive the lateral ultrasonic transducer 7 to emit ultrasonic waves, the ultrasonic waves in the radial direction (lateral direction) of the catheter are applied to the interior of the thrombus, and the whole thrombus is effectively dissolved under the combined action of the ultrasonic waves, the microbubble contrast agent and the thrombolytic drugs, particularly the partial thrombus adhered to the vascular wall is completely dissolved.
Step four: and if necessary, repeating the second step and the third step. If necessary, the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 can be simultaneously turned on, so that the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 simultaneously emit ultrasonic waves for thrombolysis treatment, and efficient and thorough dissolution of the whole thrombus can be realized.
Step five: after the fourth step is completed, the whole thrombus is effectively dissolved, and the thrombus is dissolved into thrombus plaques with micron grade, and the thrombus plaques can be absorbed along with blood circulation. In order to prevent the possibility that some large micro thrombus plaques cause further embolism along with the blood circulation flow to the far end, a suction pump is started, and the dissolved thrombus is extracted out of the body through a thrombus extraction hole 2 on the outer catheter 1, so that the thrombus is thoroughly cleared, and the far end embolism is avoided.
Through the steps one to five, the interventional combined ultrasonic thrombolysis device provided by the embodiment of the invention is utilized to carry out ultrasonic thrombolysis operation, and high-efficiency and thorough thrombolysis treatment can be carried out on various types of thrombus. The device has the advantages of high thrombolysis efficiency, thorough thrombolysis, small vascular injury and strong applicability to thrombus types, and in addition, the device can greatly reduce the dosage of thrombolytic drugs and greatly reduce the risk of complications such as hemorrhage in tissues, nerve injury and the like.
In practical application, the interventional combined ultrasonic thrombolysis device provided by the invention is suitable for various types of thrombus, and particularly has good technical advantages for old thrombus which is seriously blocked, even completely blocked or contracted. The forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7 in the device can realize ultrasonic treatment on thrombus, and for thrombus with serious blockage, the forward ultrasonic transducer 6 has different division work and mainly carries out primary dissolution on the thrombus in the early stage, so that an ultrasonic thrombolytic probe can enter the inside of the thrombus; then, the lateral ultrasonic transducer 7 is used for effectively dissolving the whole thrombus, and the synergistic effect of the two transducers shortens the treatment period and improves the clearance rate of the thrombus. It is necessary that both transducers operate simultaneously to achieve optimal thrombolytic therapy.
The invention adopts the forward ultrasonic transducer 6 and the lateral ultrasonic transducer 7, thereby optimizing the design of the ultrasonic thrombolysis probe 5. Through preceding 6 forward transmission ultrasonic waves of ultrasonic transducer for clear away the thrombus at blood vessel center, make supersound thrombolysis probe 5 can stretch into inside the thrombus, rethread side direction ultrasonic transducer 7 is to the side transmission ultrasonic wave, be used for clearing away the thrombus of blood vessel lateral wall, in order to detach the hard, firm thrombus with the vascular wall adhesion of texture. And can also inject the thrombolysis medicine to the thrombus department through the inner catheter 4, can accelerate the clearance to the thrombus, the thrombolysis medicine jets out through the through-hole on the preceding ultrasonic transducer 6 to the accurate thrombus of aiming at carries out the medicine, the use amount of thrombolysis medicine that can significantly reduce has greatly reduced the risk that takes place complications such as internal hemorrhage of tissue, nerve injury. The thrombolysis device has the advantages of high thrombolysis efficiency, thorough thrombus removal, small injury to blood vessels, strong applicability to thrombus types and the like, can obtain good effects on completely and partially blocked thrombus, and particularly has good technical advantages on completely blocked thrombus and old contracted thrombus
In this document, the terms of upper, lower, left, right, front, rear and the like are used to define the positions of the structures in the drawings and the positions of the structures relative to each other, and are only used for the sake of clarity and convenience in technical solution. It is to be understood that the use of the directional terms should not be taken to limit the scope of the claims. It is also to be understood that the terms "first" and "second," etc., are used herein for descriptive purposes only and are not to be construed as limiting in number or order.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (12)
1. An interventional combined ultrasonic thrombolysis device is characterized by comprising an outer catheter (1), an inner catheter (4), a forward ultrasonic transducer (6), a lateral ultrasonic transducer (7) and an electric signal transmission line (3), wherein the inner catheter (4) is arranged in the outer catheter (1) and forms a gap with the outer catheter (1), a bolt suction hole (2) communicated with the gap is formed in the side wall of the outer catheter (1), the forward ultrasonic transducer (6) is arranged at the front end of the outer catheter (1) and used for emitting ultrasonic waves towards the front end of the outer catheter (1), a through hole communicated with the inner catheter (4) is formed in the forward ultrasonic transducer (6), the lateral ultrasonic transducer (7) is arranged on the outer side wall of the outer catheter (1) and used for emitting ultrasonic waves towards the lateral side of the outer catheter (1), the forward ultrasonic transducer (6) and the lateral ultrasonic transducer (7) are both electrically connected with the electrical signal transmission line (3), and the electrical signal transmission line (3) is used for applying electrical signals to the forward ultrasonic transducer (6) and the lateral ultrasonic transducer (7).
2. The interventional combination sonothrombolysis device according to claim 1, wherein the forward ultrasound transducer (6) comprises a plurality of piezoceramic wafers stacked on top of each other, the polarization direction of the piezoceramic wafers being parallel to the axial direction of the outer catheter (1), the polarization direction of two adjacent piezoceramic wafers being opposite.
3. The interventional combination ultrasonic thrombolysis device according to claim 2, wherein the thickness of each of the piezoelectric ceramic plates is 0.1-0.25 mm, and two adjacent piezoelectric ceramic plates are bonded together by conductive glue.
4. The interventional combination sonothrombolysis device according to claim 1, wherein the edges of the forward ultrasound transducer (6) do not extend beyond the outer side of the outer catheter (1) and/or,
the outer side surface of the lateral ultrasonic transducer (7) is flush with the outer side surface of the outer catheter (1).
5. The interventional combination ultrasonic thrombolysis device according to claim 1, wherein the front end of the forward ultrasonic transducer (6) is provided with an acoustic matching layer, and the thickness of the acoustic matching layer is 0.5-1 mm.
6. The interventional combination sonothrombolysis device according to claim 1, wherein the lateral ultrasound transducer (7) comprises a plurality of piezoelectric ceramic rings arranged at intervals around the side wall of the outer catheter (1), the polarization direction of the piezoelectric ceramic rings being perpendicular to the axial direction of the outer catheter (1).
7. The interventional combination sonothrombolysis device of claim 6, wherein the distance between two adjacent piezoelectric ceramic rings is 1-2 mm.
8. The interventional combination sonothrombolysis device according to claim 1, wherein the suction plug hole (2) is provided between the forward ultrasound transducer (6) and the lateral ultrasound transducer (7).
9. The interventional combination sonothrombolysis device according to claim 8, wherein the number of the pipette holes (2) is plural and arranged along the circumferential or axial direction of the outer catheter (1), and the pipette holes (2) have a circular or elliptical structure.
10. The interventional combination sonothrombolysis device according to claim 1, wherein the inner catheter (4) exits the side wall of the outer catheter (1) at the end distal to the forward ultrasound transducer (6) and is bifurcated and forms a "Y" shaped double pass tube.
11. The interventional combination sonothrombolysis device according to claim 1, wherein the electrical signal transmission line (3) is provided in a wall of the outer catheter (1).
12. The interventional combination sonothrombolysis device according to claim 1, further comprising a switch (8) and an ultrasonic signal generator (9), wherein an end of the electrical signal transmission line (3) remote from the forward ultrasonic transducer (6) and the lateral ultrasonic transducer (7) is electrically connected with the ultrasonic signal generator (9) through the switch (8).
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