CN113724565A - Animal motion disease simulation device and method for simulating complex motion in three-dimensional direction - Google Patents
Animal motion disease simulation device and method for simulating complex motion in three-dimensional direction Download PDFInfo
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- 238000004088 simulation Methods 0.000 title claims abstract description 112
- 241001465754 Metazoa Species 0.000 title claims abstract description 51
- 230000033001 locomotion Effects 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 14
- 201000010099 disease Diseases 0.000 title description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 4
- 201000003152 motion sickness Diseases 0.000 claims abstract description 25
- 241000700159 Rattus Species 0.000 claims description 20
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 9
- 229940085605 saccharin sodium Drugs 0.000 claims description 9
- 238000002474 experimental method Methods 0.000 claims description 5
- 230000003203 everyday effect Effects 0.000 claims description 3
- 230000003252 repetitive effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 abstract description 10
- 230000001720 vestibular Effects 0.000 abstract description 5
- 230000001788 irregular Effects 0.000 abstract description 4
- 238000011160 research Methods 0.000 abstract description 2
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- 238000012360 testing method Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000004891 conditioned taste aversion Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
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- 230000004064 dysfunction Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
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- 230000005281 excited state Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
Abstract
The invention relates to an animal motion sickness simulation device and a simulation method for simulating complex motion in three-dimensional directions, wherein the device comprises three groups of simulation device bodies with the same structure, which are respectively defined as a first simulation device body, a second simulation device body and a third simulation device body, the first simulation device body drives the running direction of an animal cage to be defined as an X axis, the second simulation device body is arranged on the first simulation device body, the second simulation device body drives the running direction of the animal cage to be defined as a Y axis, the third simulation device body is arranged on the second simulation device body, the third simulation device body is provided with the animal cage, and the third simulation device body drives the running direction of the animal cage to be defined as a Z axis; the invention can simulate the motion mode of three-dimensional space, simultaneously realizes nonlinear irregular variable speed motion, is closer to the complex vestibular stimulation of the real situation than the existing motion sickness device, and has more accurate and reliable research result.
Description
Technical Field
The invention relates to an animal motion sickness simulation device and method for simulating complex motion in three-dimensional directions, belongs to the technical field of simulation machinery, and is suitable for the motion sickness research and treatment industry.
Background
Under specific environmental conditions (surge impact on sea, severe fluctuation of air flow, aircraft flight stunt action, change of excited state of a space gravity-eliminating body, bump and rotation on land), irregular shaking, vibration, bumping, rotation and the like of a carrier (a ship, an aircraft, a spacecraft, an automobile, a train, a tank and the like) or special equipment (a swing, a swivel chair, a roller, a wave bridge and the like) are caused, complex vestibule stimulation (angular acceleration, linear acceleration, Coriolis acceleration and gravity in different directions) and non-vestibule stimulation (vision, hearing, smell, visceral organ displacement, deep proprioception and the like) are generated, when the complex and adverse stimulation intensity is too large, the time is too long and exceeds the physiological tolerance limit of the relevant center of the body, a series of vegetative nerve dysfunction reaction can be caused, and various symptoms and physical signs appear, this is known as motion sickness.
The existing motion sickness simulation device at present has a three-degree-of-freedom motion platform, such as a three-degree-of-freedom motion simulation platform disclosed in chinese patent document CN 101339701a, which mainly comprises a frame, actuators connected with the frame, and a servo control system, wherein the frame comprises a lower frame, a middle frame, and an upper frame, the center positions of the lower frame and the middle frame are connected through a universal joint, the lower frame and the middle frame are connected through two actuators, the middle frame and the upper frame are connected through a middle actuator and two linear guide rails, and the three actuators are controlled by the servo control system to extend and retract. The motion sickness simulation and training platform comprises a mechanical system and a control system for controlling the mechanical system, wherein the mechanical system comprises a base, a detection table arranged on the base, and a vertical motion unit arranged on the base and used for driving the detection table to vertically reciprocate; the horizontal movement unit is arranged on the base and drives the detection platform to horizontally reciprocate; and the rotary motion unit is arranged on the base and drives the detection table to rotate around the y axis.
These motion simulation and training platforms have three types of motion, up and down, left and right, front and back translation or rotation. However, in the actual motion sickness simulation process, the complex vestibular stimulation (angular acceleration, linear acceleration, Coriolis acceleration and gravity in different directions) is mainly caused, particularly, nonlinear irregular acceleration is caused, but the acceleration of the motion simulation platform has strong regularity, and the complex vestibular stimulation in real situations cannot be simulated, so that the motion simulation platform cannot meet the requirements of actual motion sickness simulation.
Disclosure of Invention
The invention provides an animal motion disease simulation device and a simulation method for simulating complex motion in three-dimensional directions, which can simultaneously realize nonlinear irregular variable speed motion and can meet the simulation requirement of actual motion diseases.
The technical scheme adopted by the invention for solving the technical problems is as follows:
an animal motion sickness simulation device for simulating complex motion in three-dimensional directions comprises three groups of simulation device bodies with the same structure, wherein the three groups of simulation device bodies are respectively defined as a first simulation device body, a second simulation device body and a third simulation device body;
as a further preferred aspect of the present invention, each group of simulation apparatus bodies includes a base plate, a motor is mounted on the base plate, a rotating shaft of the motor is fixed to one end of a lead screw, and the lead screw is arranged parallel to the surface of the base plate;
a sliding block is sleeved on the screw rod, and a flat plate is fixed on the surface of the sliding block;
as a further preferred choice of the invention, a group of fixed frames are respectively arranged along two sides of the axial direction of the screw rod, a slide bar is arranged on each group of fixed frames, the slide bars and the screw rod are arranged in parallel, and the screw rod penetrates through the slide block;
as a further preference of the invention, each group of the fixed frames comprises sliding rod fixed frames which are oppositely arranged, and two ends of the sliding rod are respectively fixed on the sliding rod fixed frames;
as further optimization of the invention, the screw rod fixing frame also comprises screw rod fixing frames which are symmetrically arranged, one end of the screw rod is embedded on one screw rod fixing frame, and the part of the screw rod close to the other end is also embedded on the other screw rod fixing frame;
a simulation method of an animal motion sickness simulation device based on any one of the simulated three-dimensional complex motions specifically comprises the following steps:
step S1: establishing a three-dimensional coordinate system on the ground, respectively setting an X axis, a Y axis and a Z axis, and firstly stacking and installing a first simulation device body, a second simulation device body and a third simulation device body, wherein a bottom plate of the third simulation device body is vertically installed on a flat plate of the second simulation device body, an animal cage is fixed on the flat plate of the third simulation device body, and the animal cage is positioned at an initial point (0, 0, 0) of the three-dimensional coordinate system;
step S2: starting a motor, starting the animal cage from an initial point (0, 0, 0), and after 2-10 s, locating the animal cage at a terminal point (Z, X, Y);
step S3: starting the motor again, and returning the animal cage from the end point (Z, X, Y) to the initial point (0, 0, 0) according to the path of the step S2;
step S4: repeating the steps S2-S3 for a plurality of times;
as a further preference of the invention, the animal cage is moved over a distance in the range of 0-2m on the X-axis or Y-axis or Z-axis;
as a further preferred embodiment of the present invention, during the experiment, 40 rats are selected, and the 40 rats are divided into two groups, which are respectively defined as a control group and a Treatment group, wherein the rats in each group drink 0.15% saccharin sodium solution within five days, and the consumption of the saccharin sodium solution of the rats is recorded at the same time every day;
as a further preferred embodiment of the present invention, rats in the Treatment group are subjected to repeated passive exercise for 2 hours on the third day.
Through the technical scheme, compared with the prior art, the invention has the following beneficial effects:
1. the simulation device provided by the invention can realize multidirectional movement in a three-dimensional space, and meets the test requirements;
2. the simulation device provided by the invention can perform three-dimensional acceleration in a three-dimensional space, so that the stimulation of a test object in an experiment is closer to reality, and the complex vestibular stimulation under the actual condition can be simulated.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a side view of the preferred embodiment of the present invention in terms of movement in the X-axis and Z-axis directions;
FIG. 2 is a side view of the preferred embodiment of the present invention in the X and Y directions of movement;
FIG. 3 is a schematic structural diagram of a simulation apparatus body according to a preferred embodiment of the present invention;
fig. 4 is a comparison of the consumption of saccharin sodium solution after passive exercise in SD rats compared to the control group in the preferred embodiment of the present invention.
In the figure: the simulation device comprises a motor 1, a screw rod 2, a sliding block 3, a flat plate 4, a sliding rod 5, a sliding rod fixing frame 6, a screw rod fixing frame 7, a first simulation device body 8, a second simulation device body 9 and a third simulation device body 10.
Detailed Description
The present invention will now be described in further detail with reference to the accompanying drawings. In the description of the present application, it is to be understood that the terms "left side", "right side", "upper part", "lower part", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and that "first", "second", etc., do not represent an important degree of the component parts, and thus are not to be construed as limiting the present invention. The specific dimensions used in the present example are only for illustrating the technical solution and do not limit the scope of protection of the present invention.
The occurrence of motion sickness can produce nausea and vomiting symptoms, but rodents have no vomiting reflex, so that the occurrence of motion sickness can be evaluated only by adopting a conditional taste aversion model. The simulation platform in the prior art can not simulate complex vestibular acquisition under the actual condition, especially can not simulate variable-speed motion in the three-dimensional direction, so the technical problem of the simulation requirement of the actual motion sickness can not be met.
After many times of experimental simulation, experimenters want to achieve the expected purpose of the experiment in the simplest structural form, so as to adopt the simulation device body structure shown in fig. 3, but one simulation device body structure can only realize the movement in one direction, and needs to realize the movement in three directions in three-dimensional space simultaneously or independently, i.e. three sets of simulation device bodies with the same structure are needed, which are respectively defined as a first simulation device body 8, a second simulation device body 9 and a third simulation device body 10, as shown in fig. 1-2, the first simulation device body drives the animal cage to move in the direction defined as the X axis, the second simulation device body is installed on the first simulation device body, the second simulation device body drives the animal cage to move in the direction defined as the Y axis, the third simulation device body is installed on the second simulation device body, and the third simulation device body is installed with the animal cage, and the third simulation device body drives the moving direction of the animal cage to be defined as a Z axis, and a three-dimensional coordinate system is established.
Specifically, each group of simulation device bodies comprises a bottom plate, wherein a motor 1 is arranged on the bottom plate, a rotating shaft of the motor is fixed with one end of a screw rod 2, and the screw rod is arranged in parallel to the surface of the bottom plate; a sliding block 3 is sleeved on the screw rod, and a flat plate 4 is fixed on the surface of the sliding block; the flat plate is used for placing the animal cage for the test, in order to ensure the stability of the animal cage during the test, a group of fixing frames are respectively arranged along the two sides of the axial direction of the screw rod, each group of fixing frames is provided with a slide rod 5, the slide rods are arranged in parallel with the screw rod, the screw rod penetrates through the slide block, and the slide block is penetrated through the screw rod and the slide rods simultaneously, so that the stability of the slide block in the sliding process can be ensured; specifically, each group of fixing frames comprises sliding rod fixing frames 6 which are oppositely arranged, and two ends of each sliding rod are respectively fixed on the sliding rod fixing frames.
The lead screw is fixed through lead screw fixing frames 7 which are symmetrically arranged, one end of the lead screw is embedded on one lead screw fixing frame, and the part of the lead screw close to the other end is also embedded on the other lead screw fixing frame. With the arrangement, after the motor is started, the screw rod moves, and the stability of the operation of the flat plate can be ensured through the assistance of the slide rod,
next, the present application provides a simulation method using a simulation apparatus, specifically including the steps of:
step S1: establishing a three-dimensional coordinate system on the ground, respectively setting an X axis, a Y axis and a Z axis, and firstly stacking and installing a first simulation device body, a second simulation device body and a third simulation device body, wherein a bottom plate of the third simulation device body is vertically installed on a flat plate of the second simulation device body, an animal cage is fixed on the flat plate of the third simulation device body, and the animal cage is positioned at an initial point (0, 0, 0) of the three-dimensional coordinate system;
step S2: starting a motor, starting the animal cage from an initial point (0, 0, 0), and after 2-10 s, locating the animal cage at a terminal point (Z, X, Y); the moving distance range of the animal cage on the X axis, the Y axis or the Z axis is 0-2 m;
step S3: starting the motor again, and returning the animal cage from the end point (Z, X, Y) to the initial point (0, 0, 0) according to the path of the step S2;
step S4: the steps S2-S3 are repeated a plurality of times.
That is, in a passive movement period, the animal cage starts from the initial point (0, 0, 0), moves to the movement end point (Z, X, Y) after 2-10 seconds, and moves reversely from the end point to the initial point after the same time, and the XYZ values of the movement end point (Z, X, Y) are randomly generated in the range of 0-2 meters; the next passive movement period, starting from the initial point (0, 0, 0), moving the animal cage to the movement end point (Z, X, Y) in the same time as the previous movement period, and reversely moving the animal cage to the initial point from the end point in the same time, wherein XYZ values of the movement end point (Z, X, Y) are randomly generated within the range of 0-2 meters; stimulating repeatedly to induce experimental animal to generate motion sickness; by adjusting the period of the passive movement, the passive movement stimulation with different intensities is simulated.
Example (b):
to better demonstrate the advantages of the simulation device provided herein, rats were selected as the test subjects, and when they ingested a food with specific taste characteristics (e.g., sweetness), if they experienced visceral discomfort symptoms such as abdominal pain, diarrhea, nausea, vomiting, etc., they would reduce or refuse to ingest food with the same or similar taste characteristics during subsequent ingestion activity, a course of such behavior is called conditioned taste aversion.
During the experiment, 40 rats were selected, and 40 rats were divided into two groups, respectively defined as control group and Treatment group, and the rats in each group drunk 0.15% Saccharin Sodium Solution (SSS) within five days, and the amount of the Saccharin Sodium Solution drunk by the rats was recorded at the same time every day. The rats in the Treatment group were subjected to repeated passive exercise for 2 hours on the third day, and comparison of the difference between the average water intake of the rats for 1-3 days and 3-5 days showed that the average of the difference between the average water intake for 3-5 days and 1-3 days in the control group was-2% and the average of the difference between the average water intake for 3-5 days and 1-3 days in the Treatment group was-21%. Compared with the control group, the consumption of saccharin sodium solution after the passive exercise of the SD rat is obviously reduced (P < 0.05) compared with the control group (shown in figure 4). The above results indicate that passive motor stimulation causes SD rats to produce conditioned taste aversion behavior of drinking saccharin sodium solution, resulting in motion sickness.
It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
The meaning of "and/or" as used herein is intended to include both the individual components or both.
The term "connected" as used herein may mean either a direct connection between components or an indirect connection between components via other components.
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (9)
1. An animal motion sickness simulation device for simulating complex motion in three-dimensional direction is characterized in that: the three-dimensional simulation device comprises three groups of simulation device bodies with the same structure, wherein the three groups of simulation device bodies are respectively defined as a first simulation device body (8), a second simulation device body (9) and a third simulation device body (10), the first simulation device body (8) is used for driving the running direction of an animal cage to be defined as an X axis, the second simulation device body (9) is installed on the first simulation device body (8), the second simulation device body (9) is used for driving the running direction of the animal cage to be defined as a Y axis, the third simulation device body (10) is installed on the second simulation device body (9), the animal cage is installed on the third simulation device body (10), and the third simulation device body (10) is used for driving the running direction of the animal cage to be defined as a Z axis, so that a three-dimensional coordinate system is established.
2. The animal motion sickness simulation apparatus for simulating three-dimensional complex motion according to claim 1, wherein: each group of simulation device bodies comprises a bottom plate, a motor (1) is installed on the bottom plate, a rotating shaft of the motor (1) is fixed with one end of a screw rod (2), and the screw rod (2) is arranged in parallel to the surface of the bottom plate;
the screw rod (2) is sleeved with a sliding block (3), and a flat plate (4) is fixed on the surface of the sliding block (3).
3. The animal motion sickness simulation apparatus for simulating three-dimensional complex motion according to claim 2, wherein: a set of fixing frame is installed respectively along the both sides of lead screw (2) axial direction, installs a slide bar (5) on every group fixing frame, and slide bar (5) and lead screw (2) parallel are laid, and lead screw (2) wear to establish slider (3).
4. The animal motion sickness simulation apparatus for simulating three-dimensional complex motion according to claim 3, wherein: each group of fixed frames comprises sliding rod fixed frames (6) which are oppositely arranged, and two ends of each sliding rod (5) are respectively fixed on the sliding rod fixed frames (6).
5. The animal motion sickness simulation apparatus for simulating three-dimensional complex motion according to claim 2, wherein: the lead screw fixing frame structure comprises lead screw fixing frames (7) which are symmetrically arranged, one end of a lead screw (2) is embedded on one lead screw fixing frame (7), and the part of the lead screw close to the other end of the lead screw is also embedded on the other lead screw fixing frame (7).
6. A simulation method of an animal motion sickness simulation apparatus for simulating three-dimensional complex motion according to any one of claims 1 to 5, wherein: the method specifically comprises the following steps:
step S1: establishing a three-dimensional coordinate system on the ground, respectively setting an X axis, a Y axis and a Z axis, firstly stacking and installing a first simulation device body (8), a second simulation device body (9) and a third simulation device body (10), wherein a bottom plate of the third simulation device body (10) is vertically installed on a flat plate (4) of the second simulation device body (9), an animal cage is fixed on the flat plate (4) of the third simulation device body (10), and the animal cage is positioned at an initial point (0, 0, 0) of the three-dimensional coordinate system;
step S2: starting a motor (1), starting the animal cage from an initial point (0, 0, 0), and after 2-10 s, locating the animal cage at a final point (Z, X, Y);
step S3: starting the motor (1) again, and returning the animal cage from the end point (Z, X, Y) to the initial point (0, 0, 0) according to the path of the step S2;
step S4: the steps S2-S3 are repeated a plurality of times.
7. The simulation method of an animal motion sickness simulation apparatus for simulating three-dimensional complex motions according to claim 6, wherein: the distance moved by the animal cage on the X axis or the Y axis or the Z axis ranges from 0 to 2 m.
8. The simulation method of an animal motion sickness simulation apparatus for simulating three-dimensional complex motions according to claim 7, wherein: in the experiment, 40 rats are selected, the 40 rats are divided into two groups, namely a control group and a Treatment group, the rats in each group drink 0.15% saccharin sodium solution within five days, and the consumption of the saccharin sodium solution of the rats is recorded at the same time every day.
9. The simulation method of an animal motion sickness simulation apparatus for simulating three-dimensional complex motions according to claim 8, wherein: the rats of the Treatment group were subjected to 2-hour repetitive passive exercise on the third day.
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2021
- 2021-09-09 CN CN202111055465.3A patent/CN113724565A/en active Pending
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|---|---|---|---|---|
| US5527184A (en) * | 1993-02-05 | 1996-06-18 | Ridefilm Theaters Corporation | Simulator system having an orthogonal motion base |
| CN1862285A (en) * | 2006-06-10 | 2006-11-15 | 中国矿业大学 | Apparatus for simulating 3-D dynamic deforming vector |
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Application publication date: 20211130 |