CN113713936A - Preparation method and preparation equipment of bionic mineralized collagen scaffold - Google Patents
Preparation method and preparation equipment of bionic mineralized collagen scaffold Download PDFInfo
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- CN113713936A CN113713936A CN202110916807.XA CN202110916807A CN113713936A CN 113713936 A CN113713936 A CN 113713936A CN 202110916807 A CN202110916807 A CN 202110916807A CN 113713936 A CN113713936 A CN 113713936A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/0056—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
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Abstract
The invention belongs to the technical field of mineralized collagen scaffolds, and discloses bionic mineralized collagen scaffold preparation equipment which comprises a pressing chamber, wherein the inner cavity of the pressing chamber is movably connected with a pressing plate, the top surface of the pressing plate is fixedly provided with an annular rack, the top surface of the pressing chamber is fixedly provided with a pressing motor, the output end of the pressing motor is fixedly sleeved with a first gear, and the inner cavity of the pressing chamber is movably connected with a grinding plate. According to the bionic collagen block grinding machine, the grinding motor drives the gear III to rotate, the gear III drives the grinding plate to rotate when rotating, the grinding plate can drive the pressing plate to rotate in the opposite direction through the meshing of the driving gear, the planetary gear and the gear ring when rotating, the bionic collagen block can be directly ground through downward movement of the pressing plate and the grinding plate after compression molding during rotation, a special tool is not used for taking out the bionic collagen block, the operation is simple, and the labor difficulty of operators is reduced.
Description
Technical Field
The invention belongs to the technical field of mineralized collagen scaffolds, and particularly relates to a preparation method and preparation equipment of a bionic mineralized collagen scaffold.
Background
The vertebrate hard tissue is formed by a mineralization process of a living system, wherein mineralized collagen is a basic structural unit of the biological materials, mineralized collagen is an organic-inorganic composite material formed by collagen molecules and nano calcium phosphate minerals, a specific nano ordered multi-level structure of the mineralized collagen endows the biological hard tissue material with excellent mechanical properties, and the biomimetic mineralized collagen scaffold is a product for replacing mineralized collagen and is wide in application, so that a special preparation device is required to be used for batch production and preparation.
When the existing preparation device is used, stirring needs to be carried out in the preparation process, the bionic mineralized collagen block is pressed through the pressing die, the pressing die and grinding need to be carried out, however, when the bionic mineralized collagen block is actually used, an operator needs to use a pressing device to apply pressure, after the bionic mineralized collagen block is pressed and formed, the pressing device needs to be taken out of the bionic mineralized collagen block, when the bionic mineralized collagen block is taken out, a special tool needs to be used to take out the bionic mineralized collagen block, the operation is complex, and the labor difficulty of the operator is increased.
Present preparation facilities still need place the biomimetic mineralized collagen piece and grind into biomimetic mineralized collagen support in grinding equipment after the biomimetic mineralized collagen piece takes out, when using, needs operating personnel to take out the biomimetic mineralized collagen piece from the suppression, then places in grinding equipment, because the pressure that die assembly applyed is great, it is harder when taking out the biomimetic collagen piece, has reduced operating personnel's work efficiency.
When using, the existing preparation device needs to suppress the bionic collagen powder, when the pressure on the bionic collagen powder reaches a certain degree, one end of pressure needs to be kept, the existing pressure-applying component needs to continuously supply power to the pressure-applying component mostly when keeping the pressure, so that the pressure-maintaining effect is achieved, a large energy source needs to be consumed, and the use cost of the device is increased.
Disclosure of Invention
The invention aims to provide a preparation method and preparation equipment of a biomimetic mineralized collagen scaffold, so as to solve the problems in the background technology.
In order to achieve the above purpose, the invention provides the following technical scheme: a bionic mineralized collagen bracket preparation device comprises a pressing chamber, wherein a pressing plate is movably connected to the inner cavity of the pressing chamber, an annular rack is fixedly installed on the top surface of the pressing plate, a pressing motor is fixedly installed on the top surface of the pressing chamber, a first gear is fixedly sleeved at the output end of the pressing motor and drives the first gear to rotate, the first gear can drive the pressing plate to move downwards through meshing with the annular rack when rotating, the pressing plate can gradually apply pressure on bionic mineralized collagen powder between the pressing plate and a grinding plate when moving downwards to press, a grinding plate is movably connected to the inner cavity of the pressing chamber, as the bottom surface of the pressing plate and the top surface of the grinding plate are rough, a bionic mineralized collagen block can be ground when rotating, and ground bionic mineralized collagen particles can be pushed out to the side wall of the pressing chamber through rotation of a pushing plate, the bionic mineralized collagen particles are screened through sieve pores, a gear II is fixedly arranged on the bottom surface of the grinding plate, an inserting shaft is fixedly arranged on the bottom surface of the gear II, a lifting stud is meshed with the bottom end of the pressing chamber, a bearing pipe is fixedly arranged on the top surface of the lifting stud, the lifting stud is rotated, the bearing pipe can be driven to move downwards through the meshing of the lifting stud and the bottom end of the pressing chamber, the bottom end of the gear II loses the support of the bearing pipe and then moves downwards under the action of gravity, so that the top surface of the grinding plate is positioned below the sieve pores, a steering mechanism is movably connected to the top surface of the grinding plate, a push plate is fixedly arranged on the side wall of the steering mechanism, a grinding motor is fixedly arranged on the right side surface of the pressing chamber, a gear III is fixedly sleeved on the output end of the grinding motor, after the grinding plate moves downwards, the gear II is meshed with the gear III, and the pressing motor drives the pressing plate to move downwards through an annular uninterrupted rack, and meanwhile, the grinding motor drives the gear III to rotate, so that the grinding plate is driven to rotate anticlockwise, the bottom end of the pressing chamber is provided with a sieve mesh, and the bottom end of the pressing plate is provided with a positioning groove.
Preferably, the lateral wall fixed mounting of suppression chamber has the collecting ring, the front end fixed mounting of collecting ring bottom surface has the discharging pipe, the inner chamber swing joint of collecting ring has the rotor, and the bionic mineralized collagen granule that comes out from the sieve mesh can drop in the inner chamber of collecting ring, when taking out bionic mineralized collagen granule, through the rotatory a week of axis with the rotor along the suppression chamber, can realize pushing away the bionic mineralized collagen granule to the discharging pipe top to from discharging pipe eduction gear, thereby obtain the bionic mineralized collagen support.
Preferably, a fixed box is fixedly mounted at the top end of the pressing chamber, a roller screw is movably connected to the middle of the fixed box, meshing plates are meshed with the front end and the rear end of the roller screw, locking teeth are fixedly mounted on one surface, close to the annular rack, of the meshing plate, two threads with opposite rotation directions are formed in the surface of the roller screw, the locking teeth are clamped with the annular rack, the roller screw is rotated, the locking teeth are driven to move towards the annular rack through the meshing of the two meshing plates through the meshing of the roller screw and the two meshing plates, after the locking teeth are clamped in the annular rack, the position of the pressing plate is positioned, and then the pressure is stored for 24-120 hours, so that the bionic mineralized collagen block is obtained.
Preferably, the bottom surface fixed mounting of pressing chamber has the support base, the through-hole has been seted up to the front end of supporting the base, the front end swing joint of pressing chamber has sealed door plant, the through-hole is located the dead ahead of lift double-screw bolt bottom, can rotate the bottom of lift double-screw bolt through the through-hole, opens sealed door plant and places the bionical mineralize collagen powder that obtains between clamp plate and grinding plate, then will seal the door plant and close, can realize adding bionical mineralize collagen powder through sealed door plant.
Preferably, steering mechanism is including the installation piece, installation piece swing joint is in the top of lapping plate, the inner wall fixed mounting of installation piece has the ring gear, the bottom surface swing joint of installation piece inner chamber has planetary gear, ring gear and planetary gear meshing, the middle part fixed mounting of installation piece inner chamber bottom surface has locating component, and the lapping plate drives the driving gear to rotate when rotatory, both ends through planetary gear respectively with driving gear and ring gear meshing to can realize driving the ring gear and rotate clockwise, the ring gear can drive installation piece and push pedal clockwise when rotating, thereby drive the opposite direction of rotation of clamp plate and lapping plate.
Preferably, the positioning assembly comprises a positioning clamp, the positioning clamp is fixedly installed in the middle of the bottom surface of the inner cavity of the installation block, a positioning plate is movably connected to the middle of the positioning clamp, a driving gear is fixedly installed in the middle of the positioning plate, the bottom end of the driving gear is fixedly installed on the top surface of the grinding plate, and the positioning clamp and the positioning plate are matched with each other, so that the steering mechanism and the push plate can be driven to move up and down simultaneously when the grinding plate moves up and down, and the normal operation of the device is guaranteed.
Preferably, the pressing plate is located above the steering mechanism, the projections of the steering mechanism and the pushing plate in the vertical direction are located in an inner cavity of the positioning groove, and the steering mechanism and the pushing plate can be driven to rotate along with the pushing plate simultaneously through the steering mechanism and the pushing plate after being inserted into the positioning groove.
Preferably, the bottom of collecting ring is located the below of sieve mesh, the top surface of collecting ring is located the top of sieve mesh, the rear end joint of rotor is in the middle of collecting ring and sieve mesh, and the rotor can promote the concentrated discharge of bionic mineralized collagen support when rotatory, avoids the bionic mineralized collagen support to remain in collecting ring.
Preferably, the method comprises the following steps:
dissolving collagen in hydrochloric acid to prepare an acid solution of the collagen, and then continuously stirring and slowly adding a solution containing calcium ions and a solution containing phosphate ions;
slowly dropping a NaOH solution into the solution obtained in the step to obtain a mixed system, wherein the mixed system begins to precipitate when the pH value is 5-6, and a white suspension appears when the pH value is 7;
then standing the mixed system obtained in the step for 24-120 hours, separating out precipitates, washing away impurity ions, then carrying out freeze drying, and grinding to obtain biomimetic mineralized collagen powder;
opening the sealing door plate, placing the obtained biomimetic mineralized collagen powder between the pressing plate and the grinding plate, and then closing the sealing door plate;
then the pressing motor drives the gear I to rotate, the gear I can drive the pressing plate to move downwards through meshing with the annular rack when rotating, and the pressing plate can gradually apply pressure to the biomimetic mineralized collagen powder positioned between the pressing plate and the grinding plate to press when moving downwards;
when the pressure applied to the biomimetic mineralized collagen powder reaches 900-1200 MPa, the steering mechanism and the push plate are inserted into the positioning groove, the roller screw is rotated, the locking teeth can be driven to move towards the annular rack through the engagement of the roller screw and the two engaging plates, after the locking teeth are clamped in the annular rack, the position of the pressing plate is positioned, and then the pressure is stored for 24-120 hours, so that the biomimetic mineralized collagen block is obtained;
then, the roller screw rod is rotated reversely, the locking teeth loosen the annular rack, then the lifting stud is rotated, the bearing pipe can be driven to move downwards through the meshing of the lifting stud and the bottom end of the pressing chamber, and the bottom end of the second gear can move downwards under the action of gravity after losing the support of the bearing pipe, so that the top surface of the grinding plate is positioned below the sieve mesh;
when the grinding plate moves downwards, the second gear is meshed with the third gear, the pressing motor continuously drives the pressing plate to move downwards through the annular rack, and meanwhile, the grinding motor drives the third gear to rotate, so that the grinding plate is driven to rotate anticlockwise;
the grinding plate drives the driving gear to rotate when rotating, and the two ends of the planetary gear are respectively meshed with the driving gear and the gear ring, so that the gear ring can be driven to rotate clockwise, the gear ring can drive the mounting block and the push plate to rotate clockwise when rotating, so that the rotating directions of the press plate and the grinding plate are opposite, the bottom surface of the press plate and the top surface of the grinding plate are rough, the bionic mineralized collagen block can be ground when rotating, ground bionic mineralized collagen particles can be pushed out to the side wall of the pressing chamber through the rotation of the push plate, and the bionic mineralized collagen particles are screened through the sieve mesh;
the bionic mineralized collagen particle that comes out from the sieve mesh can fall in the inner chamber of collecting ring, when taking out bionic mineralized collagen particle, through the rotatory a week of the axis of following the suppression room with the revolving fragment, can realize pushing away bionic mineralized collagen particle to discharging pipe top to from discharging pipe eduction gear, thereby obtain bionic mineralized collagen support.
Preferably, the collagen concentration is 5.0 x 10 < -5 > to 5.0 x 10 < -3 > g/mL, the hydrochloric acid can be replaced by any one of nitric acid and acetic acid, and the molar ratio of the addition amount of phosphate ions to the addition amount of calcium ions is 1/1 to 1/2.
The invention has the following beneficial effects:
1. according to the bionic collagen block grinding machine, the grinding motor drives the gear III to rotate, the gear III drives the grinding plate to rotate when rotating, the grinding plate can drive the pressing plate to rotate in the opposite direction through the meshing of the driving gear, the planetary gear and the gear ring when rotating, the bionic collagen block can be directly ground through downward movement of the pressing plate and the grinding plate after compression molding during rotation, a special tool is not used for taking out the bionic collagen block, the operation is simple, and the labor difficulty of operators is reduced.
2. According to the bionic collagen block grinding device, the sieve pores are formed in the bottom end of the pressing chamber, the pressing plate and the grinding plate respectively rotate in opposite directions when the bionic collagen powder is pressed and formed, the bionic collagen block can be ground during rotation due to the rough surfaces of the pressing plate and the grinding plate, and the bionic collagen block is not required to be taken out of the device when the bionic collagen block is prepared and placed in the grinding equipment, so that the working efficiency of operators is greatly improved.
3. According to the invention, the locking teeth are arranged at the front end and the rear end of the annular rack, when the applied pressure needs to be kept, the roller screw rod is rotated, the locking teeth can be driven to move towards the annular rack by the meshing of the two meshing plates through the meshing of the roller screw rod and the two meshing plates, and when the locking teeth are clamped in the annular rack, the annular rack can be locked, so that the pressing motor can be powered off, the energy required by the device when the pressure is kept is effectively reduced, and the use cost of the device is reduced.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of an explosive connection structure of a rotor plate according to the present invention;
FIG. 3 is a schematic cross-sectional view of a pressing chamber according to the present invention;
FIG. 4 is a schematic view of the explosion-proof connection structure of the fixing box of the present invention;
FIG. 5 is a schematic cross-sectional view of the faucet tube of the present invention;
FIG. 6 is a cross-sectional structural schematic view of the steering mechanism of the present invention;
FIG. 7 is a schematic view of an explosive connection configuration of the steering mechanism of the present invention;
FIG. 8 is an enlarged view of the structure at A in FIG. 3 according to the present invention;
FIG. 9 is an enlarged view of the structure at B in FIG. 3 according to the present invention;
FIG. 10 is an enlarged view of the structure of FIG. 7 at C according to the present invention.
In the figure: 1. a pressing chamber; 2. pressing a plate; 3. an annular rack; 4. pressing the motor; 5. a first gear; 6. a grinding plate; 7. a second gear; 8. a plug shaft; 9. a lifting stud; 10. a bearing pipe; 11. a steering mechanism; 111. mounting blocks; 112. a ring gear; 113. a planetary gear; 114. a positioning assembly; 1141. positioning clips; 1142. positioning a plate; 1143. a driving gear; 12. pushing the plate; 13. grinding the motor; 14. a third gear; 15. screening holes; 16. a collection ring; 17. a discharge pipe; 18. rotating the sheet; 19. a fixing box; 20. a roller screw; 21. an engaging plate; 22. a locking tooth; 23. positioning a groove; 24. a support base; 25. a sealing door panel; 26. and a through hole.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 10, in the embodiment of the present invention, a biomimetic mineralized collagen scaffold preparation apparatus includes a pressing chamber 1, an inner cavity of the pressing chamber 1 is movably connected with a pressing plate 2, a top surface of the pressing plate 2 is fixedly provided with an annular rack 3, a top surface of the pressing chamber 1 is fixedly provided with a pressing motor 4, an output end of the pressing motor 4 is fixedly sleeved with a first gear 5, the pressing motor 4 drives the first gear 5 to rotate, the first gear 5 can drive the pressing plate 2 to move downward by meshing with the annular rack 3 during rotation, the pressing plate 2 can gradually apply pressure to the biomimetic mineralized collagen powder located between the pressing plate 2 and the grinding plate 6 to press when moving downward, the inner cavity of the pressing chamber 1 is movably connected with the grinding plate 6, since a bottom surface of the pressing plate 2 and a top surface of the grinding plate 6 are rough, when rotating, the biomimetic mineralized collagen cake can be ground, and by rotation of the pushing plate 12, the crushed bionic mineralized collagen particles can be pushed out to the side wall of the pressing chamber 1, the bionic mineralized collagen particles are screened through a sieve mesh 15, a second gear 7 is fixedly installed on the bottom surface of the grinding plate 6, an inserting shaft 8 is fixedly installed on the bottom surface of the second gear 7, a lifting stud 9 is meshed with the bottom end of the pressing chamber 1, a bearing pipe 10 is fixedly installed on the top surface of the lifting stud 9, the lifting stud 9 is rotated, the bearing pipe 10 can be driven to move downwards through the meshing of the lifting stud 9 and the bottom end of the pressing chamber 1, the bottom end of the second gear 7 can move downwards under the action of gravity after losing the support of the bearing pipe 10, so that the top surface of the grinding plate 6 is located below the sieve mesh 15, a steering mechanism 11 is movably connected to the top surface of the grinding plate 6, a push plate 12 is fixedly installed on the side wall of the steering mechanism 11, a grinding motor 13 is fixedly installed on the right side surface of the pressing chamber 1, a third gear 14 is fixedly sleeved at the output end of the grinding motor 13, after the grinding plate 6 moves downwards, the second gear 7 is meshed with the third gear 14, the pressing motor 4 continuously drives the pressing plate 2 to move downwards through the annular rack 3, meanwhile, the grinding motor 13 drives the third gear 14 to rotate, so that the grinding plate 6 is driven to rotate anticlockwise, the sieve holes 15 are formed in the bottom end of the pressing chamber 1, and the positioning grooves 23 are formed in the bottom end of the pressing plate 2.
Wherein, the lateral wall fixed mounting of suppression room 1 has collecting ring 16, the front end fixed mounting of collecting ring 16 bottom surface has discharging pipe 17, collecting ring 16's inner chamber swing joint has rotor 18, the biomimetic mineralized collagen granule that comes out from sieve mesh 15 can drop in collecting ring 16's inner chamber, when taking out biomimetic mineralized collagen granule, through rotating the rotor 18 along the rotatory a week of axis of suppression room 1, can realize pushing away biomimetic mineralized collagen granule to discharging pipe 17 top, and from discharging pipe 17 educt gear, thereby obtain the biomimetic mineralized collagen support.
The top end of the pressing chamber 1 is fixedly provided with a fixing box 19, the middle part of the fixing box 19 is movably connected with a roller screw 20, the front end and the rear end of the roller screw 20 are meshed with meshing plates 21, one surface, close to the annular rack 3, of each meshing plate 21 is fixedly provided with locking teeth 22, the surface of the roller screw 20 is provided with two threads with opposite rotating directions, the locking teeth 22 are clamped with the annular rack 3, the roller screw 20 is rotated, the locking teeth 22 are driven to move towards the annular rack 3 through meshing of the roller screw 20 and the two meshing plates 21, when the locking teeth 22 are clamped in the annular rack 3, the position of the pressing plate 2 is positioned, and then the pressure is preserved for 24-120 hours, so that the bionic mineralized collagen block is obtained.
Wherein, the bottom surface fixed mounting of pressing chamber 1 has a support base 24, support base 24's front end has seted up through-hole 26, the front end swing joint of pressing chamber 1 has sealing door board 25, through-hole 26 is located the dead ahead of lift double-screw bolt 9 bottom, can rotate the bottom of lift double-screw bolt 9 through-hole 26, open sealing door board 25 and place the bionical mineralize mineralization collagen powder that obtains between clamp plate 2 and abrasive disc 6, then close sealing door board 25, can realize adding bionical mineralize mineralization collagen powder through sealing door board 25.
Wherein, steering mechanism 11 includes installation piece 111, installation piece 111 swing joint is in the top of lapping plate 6, the inner wall fixed mounting of installation piece 111 has ring gear 112, the bottom surface swing joint of installation piece 111 inner chamber has planetary gear 113, ring gear 112 and planetary gear 113 mesh, the middle part fixed mounting of installation piece 111 inner chamber bottom surface has locating component 114, lapping plate 6 drives driving gear 1143 to rotate when rotatory, both ends through planetary gear 113 mesh with driving gear 1143 and ring gear 112 respectively, thereby can realize driving ring gear 112 clockwise, ring gear 112 can drive installation piece 111 and push pedal 12 clockwise when rotating, thereby it is opposite with lapping plate 6's direction of rotation to drive clamp plate 2.
Wherein, locating component 114 includes locating clip 1141, locating clip 1141 fixed mounting is in the middle part of installation piece 111 inner chamber bottom surface, the middle part swing joint of locating clip 1141 has locating plate 1142, the middle part fixed mounting of locating plate 1142 has driving gear 1143, the bottom fixed mounting of driving gear 1143 is on the top surface of abrasive sheet 6, cooperation between locating clip 1141 and the locating plate 1142, it reciprocates simultaneously to have realized driving steering mechanism 11 and push pedal 12 when abrasive sheet 6 reciprocates, the normal operating of device has been guaranteed.
Wherein, clamp plate 2 is located steering mechanism 11's top, and steering mechanism 11 and push pedal 12 are located the inner chamber of constant head tank 23 in the ascending projection of vertical direction, and after steering mechanism 11 and push pedal 12 pegged graft in constant head tank 23, can drive clamp plate 2 and follow push pedal 12 and rotate simultaneously through steering mechanism 11 and push pedal 12.
Wherein, the bottom of collecting ring 16 is located the below of sieve mesh 15, and the top surface of collecting ring 16 is located the top of sieve mesh 15, and the rear end joint of rotor 18 is in the middle of collecting ring 16 and sieve mesh 15, and rotor 18 can promote the concentrated discharge of biomimetic mineralized collagen support when rotatory, avoids biomimetic mineralized collagen support to remain in collecting ring 16.
The method comprises the following steps:
dissolving collagen in hydrochloric acid to prepare an acid solution of the collagen, and then continuously stirring and slowly adding a solution containing calcium ions and a solution containing phosphate ions;
slowly dropping a NaOH solution into the solution obtained in the step to obtain a mixed system, wherein the mixed system begins to precipitate when the pH value is 5-6, and a white suspension appears when the pH value is 7;
then standing the mixed system obtained in the step for 24-120 hours, separating out precipitates, washing away impurity ions, then carrying out freeze drying, and grinding to obtain biomimetic mineralized collagen powder;
opening the sealing door plate, placing the obtained biomimetic mineralized collagen powder between the pressing plate and the grinding plate, and then closing the sealing door plate;
then the pressing motor drives the gear I to rotate, the gear I can drive the pressing plate to move downwards through meshing with the annular rack when rotating, and the pressing plate can gradually apply pressure to the biomimetic mineralized collagen powder positioned between the pressing plate and the grinding plate to press when moving downwards;
when the pressure applied to the biomimetic mineralized collagen powder reaches 900-1200 MPa, the steering mechanism and the push plate are inserted into the positioning groove, the roller screw is rotated, the locking teeth can be driven to move towards the annular rack through the engagement of the roller screw and the two engaging plates, after the locking teeth are clamped in the annular rack, the position of the pressing plate is positioned, and then the pressure is stored for 24-120 hours, so that the biomimetic mineralized collagen block is obtained;
then, the roller screw rod is rotated reversely, the locking teeth loosen the annular rack, then the lifting stud is rotated, the bearing pipe can be driven to move downwards through the meshing of the lifting stud and the bottom end of the pressing chamber, and the bottom end of the second gear can move downwards under the action of gravity after losing the support of the bearing pipe, so that the top surface of the grinding plate is positioned below the sieve mesh;
when the grinding plate moves downwards, the second gear is meshed with the third gear, the pressing motor continuously drives the pressing plate to move downwards through the annular rack, and meanwhile, the grinding motor drives the third gear to rotate, so that the grinding plate is driven to rotate anticlockwise;
the grinding plate drives the driving gear to rotate when rotating, and the two ends of the planetary gear are respectively meshed with the driving gear and the gear ring, so that the gear ring can be driven to rotate clockwise, the gear ring can drive the mounting block and the push plate to rotate clockwise when rotating, so that the rotating directions of the press plate and the grinding plate are opposite, the bottom surface of the press plate and the top surface of the grinding plate are rough, the bionic mineralized collagen block can be ground when rotating, ground bionic mineralized collagen particles can be pushed out to the side wall of the pressing chamber through the rotation of the push plate, and the bionic mineralized collagen particles are screened through the sieve mesh;
the bionic mineralized collagen particle that comes out from the sieve mesh can fall in the inner chamber of collecting ring, when taking out bionic mineralized collagen particle, through the rotatory a week of the axis of following the suppression room with the revolving fragment, can realize pushing away bionic mineralized collagen particle to discharging pipe top to from discharging pipe eduction gear, thereby obtain bionic mineralized collagen support.
Wherein the concentration of the collagen is 5.0 x 10 < -5 > to 5.0 x 10 < -3 > g/mL, the hydrochloric acid can be replaced by any one of nitric acid or acetic acid, and the molar ratio of the addition amount of phosphate ions to the addition amount of calcium ions is 1/1 to 1/2.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The utility model provides a bionical mineralize mineralization collagen support preparation equipment, includes suppression room (1), its characterized in that: the inner chamber swing joint of suppression room (1) has clamp plate (2), the top surface fixed mounting of clamp plate (2) has annular rack (3), the top surface fixed mounting of suppression room (1) has suppression motor (4), the fixed cover of output of suppression motor (4) has geared one (5), the inner chamber swing joint of suppression room (1) has abrasive disc (6), the bottom surface fixed mounting of abrasive disc (6) has gear two (7), the bottom surface fixed mounting of gear two (7) has spigot shaft (8), the bottom meshing of suppression room (1) has lift double-screw bolt (9), the top surface fixed mounting of lift double-screw bolt (9) has socket pipe (10), the top surface swing joint of abrasive disc (6) has steering mechanism (11), the lateral wall fixed mounting of steering mechanism (11) has push pedal (12), the right flank fixed mounting of suppression room (1) has grinding motor (13), the output end of the grinding motor (13) is fixedly sleeved with a gear III (14), the bottom end of the pressing chamber (1) is provided with a sieve mesh (15), and the bottom end of the pressing plate (2) is provided with a positioning groove (23).
2. The biomimetic mineralized collagen scaffold preparation device according to claim 1, wherein: the lateral wall fixed mounting of suppression room (1) has collection ring (16), the front end fixed mounting of collection ring (16) bottom surface has discharging pipe (17), the inner chamber swing joint of collection ring (16) has rotor (18).
3. The biomimetic mineralized collagen scaffold preparation device according to claim 1, wherein: the top fixed mounting of suppression room (1) has fixed box (19), the middle part swing joint of fixed box (19) has roller screw (20), both ends meshing has meshing board (21) around roller screw (20), one side fixed mounting that meshing board (21) are close to annular rack (3) has locking tooth (22), two opposite screw threads of direction of rotation are seted up on the surface of roller screw (20), locking tooth (22) and annular rack (3) joint each other.
4. The biomimetic mineralized collagen scaffold preparation device according to claim 1, wherein: the bottom surface fixed mounting of suppression room (1) has support base (24), through-hole (26) have been seted up to the front end of supporting base (24), the front end swing joint of suppression room (1) has sealed door plant (25), through-hole (26) are located the dead ahead of lift double-screw bolt (9) bottom.
5. The biomimetic mineralized collagen scaffold preparation device according to claim 1, wherein: steering mechanism (11) are including installation piece (111), installation piece (111) swing joint is in the top of lapping plate (6), the inner wall fixed mounting of installation piece (111) has ring gear (112), the bottom surface swing joint of installation piece (111) inner chamber has planetary gear (113), ring gear (112) and planetary gear (113) meshing, the middle part fixed mounting of installation piece (111) inner chamber bottom surface has locating component (114).
6. The biomimetic mineralized collagen scaffold preparation device according to claim 5, wherein: locating component (114) includes locating clip (1141), locating clip (1141) fixed mounting is in the middle part of installation piece (111) inner chamber bottom surface, the middle part swing joint of locating clip (1141) has locating plate (1142), the middle part fixed mounting of locating plate (1142) has driving gear (1143), the bottom fixed mounting of driving gear (1143) is on the top surface of grinding plate (6).
7. The biomimetic mineralized collagen scaffold preparation device according to claim 1, wherein: the pressing plate (2) is positioned above the steering mechanism (11), and the projections of the steering mechanism (11) and the pushing plate (12) in the vertical direction are positioned in the inner cavity of the positioning groove (23).
8. The biomimetic mineralized collagen scaffold preparation device according to claim 2, wherein: the bottom end of the collecting ring (16) is positioned below the sieve holes (15), the top surface of the collecting ring (16) is positioned above the sieve holes (15), and the rear end of the rotary piece (18) is clamped between the collecting ring (16) and the sieve holes (15).
9. The method for preparing a biomimetic mineralized collagen scaffold according to any one of claims 1 to 8, wherein: the method comprises the following steps:
dissolving collagen in hydrochloric acid to prepare an acid solution of the collagen, and then continuously stirring and slowly adding a solution containing calcium ions and a solution containing phosphate ions;
slowly dropping a NaOH solution into the solution obtained in the step to obtain a mixed system, wherein the mixed system begins to precipitate when the pH value is 5-6, and a white suspension appears when the pH value is 7;
then standing the mixed system obtained in the step for 24-120 hours, separating out precipitates, washing away impurity ions, then carrying out freeze drying, and grinding to obtain biomimetic mineralized collagen powder;
opening the sealing door plate, placing the obtained biomimetic mineralized collagen powder between the pressing plate and the grinding plate, and then closing the sealing door plate;
then the pressing motor drives the gear I to rotate, the gear I can drive the pressing plate to move downwards through meshing with the annular rack when rotating, and the pressing plate can gradually apply pressure to the biomimetic mineralized collagen powder positioned between the pressing plate and the grinding plate to press when moving downwards;
when the pressure applied to the biomimetic mineralized collagen powder reaches 900-1200 MPa, the steering mechanism and the push plate are inserted into the positioning groove, the roller screw is rotated, the locking teeth can be driven to move towards the annular rack through the engagement of the roller screw and the two engaging plates, after the locking teeth are clamped in the annular rack, the position of the pressing plate is positioned, and then the pressure is stored for 24-120 hours, so that the biomimetic mineralized collagen block is obtained;
then, the roller screw rod is rotated reversely, the locking teeth loosen the annular rack, then the lifting stud is rotated, the bearing pipe can be driven to move downwards through the meshing of the lifting stud and the bottom end of the pressing chamber, and the bottom end of the second gear can move downwards under the action of gravity after losing the support of the bearing pipe, so that the top surface of the grinding plate is positioned below the sieve mesh;
when the grinding plate moves downwards, the second gear is meshed with the third gear, the pressing motor continuously drives the pressing plate to move downwards through the annular rack, and meanwhile, the grinding motor drives the third gear to rotate, so that the grinding plate is driven to rotate anticlockwise;
the grinding plate drives the driving gear to rotate when rotating, and the two ends of the planetary gear are respectively meshed with the driving gear and the gear ring, so that the gear ring can be driven to rotate clockwise, the gear ring can drive the mounting block and the push plate to rotate clockwise when rotating, so that the rotating directions of the press plate and the grinding plate are opposite, the bottom surface of the press plate and the top surface of the grinding plate are rough, the bionic mineralized collagen block can be ground when rotating, ground bionic mineralized collagen particles can be pushed out to the side wall of the pressing chamber through the rotation of the push plate, and the bionic mineralized collagen particles are screened through the sieve mesh;
the bionic mineralized collagen particle that comes out from the sieve mesh can fall in the inner chamber of collecting ring, when taking out bionic mineralized collagen particle, through the rotatory a week of the axis of following the suppression room with the revolving fragment, can realize pushing away bionic mineralized collagen particle to discharging pipe top to from discharging pipe eduction gear, thereby obtain bionic mineralized collagen support.
10. The method for preparing a biomimetic mineralized collagen scaffold according to claim 9, wherein: the collagen concentration is 5.0 × 10-5～5.0×10-3g/mL, hydrochloric acid can be replaced by any one of nitric acid and acetic acid, and the molar ratio of the addition amount of phosphate ions to the addition amount of calcium ions is 1/1-1/2.
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| CN202110916807.XA CN113713936A (en) | 2021-08-11 | 2021-08-11 | Preparation method and preparation equipment of bionic mineralized collagen scaffold |
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| CN202110916807.XA CN113713936A (en) | 2021-08-11 | 2021-08-11 | Preparation method and preparation equipment of bionic mineralized collagen scaffold |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114669382A (en) * | 2022-05-31 | 2022-06-28 | 唐山职业技术学院 | Dry animal husbandry is bred and is smashed grinding device with fodder that can disinfect |
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2021
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114669382A (en) * | 2022-05-31 | 2022-06-28 | 唐山职业技术学院 | Dry animal husbandry is bred and is smashed grinding device with fodder that can disinfect |
| CN114669382B (en) * | 2022-05-31 | 2022-08-02 | 唐山职业技术学院 | Dry animal husbandry is bred and is smashed grinding device with fodder that can disinfect |
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