CN113712835A - Cleansing oil containing astaxanthin liposome and preparation method thereof - Google Patents
Cleansing oil containing astaxanthin liposome and preparation method thereof Download PDFInfo
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- CN113712835A CN113712835A CN202111160648.1A CN202111160648A CN113712835A CN 113712835 A CN113712835 A CN 113712835A CN 202111160648 A CN202111160648 A CN 202111160648A CN 113712835 A CN113712835 A CN 113712835A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses cleansing oil containing astaxanthin liposome, which comprises liposome, astaxanthin and a high skin affinity preparation, and the preparation method of the cleansing oil provided by the invention comprises the following steps: s1, weighing the raw materials according to the formula; s2, mixing the obtained cetyl ethyl hexanoate, squalane, pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), polyglycerol-6 didecanoate, polyglycerol-2 decanoate, liposome and dopamine at 45-60 ℃ to obtain a phase A; s3, mixing astaxanthin with the A phase to obtain a B phase, and coating a high skin affinity preparation on the B phase, wherein the obtained cleansing oil has the efficacy of cleaning the face in multiple layers, and the step S3 adopts the following equipment: the processing shell comprises a semicircular shell and an arc-shaped shell which are connected with each other, a hydraulic pump is installed on the inner wall of the top of the semicircular shell, and a middle column is fixed inside the processing shell through welding.
Description
Technical Field
The invention relates to the technical field of makeup removing oil preparation, in particular to makeup removing oil containing astaxanthin liposome and a preparation method thereof.
Background
Cleaning is the first step of skin care, so cleaning and makeup removal are of great significance, color makeup on the surface of the skin and dirt in pores are removed, the skin is enabled to keep acid-base balance, the stratum corneum is softened, and the metabolic capacity is enhanced. In a narrow sense, makeup removal can only remove dirt on the surface of the skin, but cannot clean deeply, and can affect the absorption of skin care products by the skin. Before the early 20 th century, some people need to remove heavy color cosmetics and greasy on the face, baby oil or other grease is generally used, the idea of removing the cosmetics by oil dissolving is not wrong, the color cosmetics can be well removed, but the cleaning of the newly added greasy is troublesome, and a large amount of grease can block skin pores. Until 1960, Japanese Makeup pharmacist, Zhaochun, witnessed actors in the working period and removed heavy makeup with grease, however, the grease is not easy to clean, so that the grease is added with an emulsifier component, can be easily combined with makeup oil stain on the skin, and then is completely removed by water emulsification during washing.
The existing cleansing oil can not clean the greasy dirt on the skin and the face and has poor practicability. Therefore, it is necessary to design a highly practical cleansing oil containing astaxanthin liposome and a preparation method thereof.
Disclosure of Invention
The invention aims to provide cleansing oil containing astaxanthin liposome and a preparation method thereof, which aim to solve the problems in the background technology.
In order to solve the technical problems, the invention provides the following technical scheme:
the cleansing oil containing the astaxanthin liposome comprises the following components in parts by weight: 50-85 parts of cetyl ethyl hexanoate, 5-35 parts of squalane, 0.03-0.1 part of pentaerythritol tetrakis (bis-tert-butyl hydroxy hydrocinnamate), 1.5-4 parts of polyglycerol-6 didecanoate, 5.5-8.5 parts of polyglycerol-2 decanoate, 70-100 parts of liposome, 0.1-1 part of astaxanthin, 0.02-0.07 part of dopamine and 0.3-2 parts of high skin affinity preparation.
Wherein, the addition of dopamine can exert the special effect of self-oxidation self-assembly during use, provide good film-forming effect and also prolong the effective acting time of easily-oxidized components such as astaxanthin in the cleansing oil.
Further, the high skin affinity preparation is prepared from a targeting functional substance and bacterial cellulose in a mass ratio of 30-50: 1 in the composition of claim 1. The bacterial cellulose has the advantages of high-efficiency moisture absorption, and can well disperse negative ions in the preparation with high skin affinity by being matched with the negative ions exerted by the hexacyclic stone component, so that the skin is cleaned and the water is deeply supplemented.
Still further, the targeting function: according to the mass ratio of 1: 8-13: and 2-5, mixing the tetrahydromethylpyrimidine carboxylic acid, water and the hexacyclic stone micro powder, keeping the temperature at 40-55 ℃, shaking, and heating to 100 ℃ to remove water.
The tetrahydro-methyl pyrimidine carboxylic acid used in the invention can play a chemical transmitter-like role in cells, has a stable protection effect on the cells in adverse environment, can also stabilize the structure of enzyme protein in organisms, has the functions of activating skin and resisting aging, can also provide good moisturizing and whitening functions, has extremely strong water molecule complexing capacity, and can complex four to five skin free water molecules by one tetrahydro-methyl pyrimidine carboxylic acid molecule, so that skin tencel free water is structured and moisture is continuously locked. The used hexacyclic ring stone has anti-aging effect, eliminates the effect of free radicals in body, and can release far infrared ray, because the far infrared ray is close to the vibration frequency of cell molecules in human body, after permeating into face, it can cause the resonance of atoms and molecules of face cells, through resonance absorption, the molecules generate heat by friction to form heat reaction, promote the temperature of subcutaneous deep layer to rise, expand the capillary, accelerate blood circulation, help to remove the accumulated matter of blood vessel, harmful substance in body and facial oil dirt, revive the tissue, achieve the purpose of activating tissue cells, preventing aging, strengthening immune system ability. The anion generated by the six-ring stone can also improve the balance of facial microcirculation, promote metabolism of human body and has various health care effects.
According to the invention, the tetrahydro-methyl pyrimidine carboxylic acid is compounded with the hexacyclic stone micro powder, so that the targeted cleaning effect on facial skin is achieved, a large amount of negative ions generated by the hexacyclic stone are cooperated with the tetrahydro-methyl pyrimidine carboxylic acid in the processes of heat preservation, vibration, temperature rise and dehydration, and when the composition is applied, the composition can be used for keeping water and simultaneously acting on warm cleaning of the face to remove deep-layer greasy dirt.
Furthermore, the particle size of the hexacyclic ring stone micro powder is 100-250 μm. The small-particle-size hexacyclic stone micro powder is better matched with the use of the face (the average size of the skin of the face is 50-150 mu m), and provides proper and sufficient negative ions, so that the effects of cleaning the face and improving microcirculation are achieved.
According to the technical scheme, the method comprises the following preparation steps:
s1, weighing the raw materials according to the formula;
s2, mixing the obtained cetyl ethyl hexanoate, squalane, pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), polyglycerol-6 didecanoate, polyglycerol-2 decanoate, liposome and dopamine at 45-60 ℃ to obtain a phase A;
s3, mixing astaxanthin with the A phase to obtain a B phase, and coating the high skin affinity preparation on the B phase to obtain the cleansing oil containing astaxanthin liposome.
According to the technical scheme, the step S3 adopts the following equipment: comprises a processing shell (1), the processing shell (1) is composed of a semicircular shell (11) and an arc-shaped shell (12) which are connected with each other, a hydraulic pump (61) is installed on the inner wall of the top of the semicircular shell (11), a middle column (3) is fixed inside the processing shell (1) through welding, one end of the middle column (3) is provided with two rotary cylinders (4), the two rotary cylinders (4) are stacked up and down, and the output ends of the two rotary cylinders (4) are respectively connected with a supporting rod (41), one end of the supporting rod (41) is movably connected with a rolling column (42) through a bearing, the outer wall of the rolling column (42) is provided with a through hole, astaxanthin is filled in the through hole, the top of the rotary cylinder (4) is connected with a column cap (31), the diameter of the column head (31) is the same as that of the middle column (3), and the bottom of the rolling column (42) is provided with a pouring head (421).
According to the technical scheme, the motor is fixed to one end of the rolling column through welding, the output shaft of the motor is connected with the pressing plate through the coupler, nail-shaped teeth are evenly installed on one side of the pressing plate, the pressing plate is matched with the arc shell in shape, and the pressing plate is movably connected with the rolling column through the bearing.
According to the technical scheme, the coating hole has evenly been seted up to one side of arc shell, one side of intermediate pillar has the holding tank through welded fastening, one side correspondence of holding tank is installed flexible cover, one side of flexible cover contacts with the inner wall of arc shell, the top periphery circle department of intermediate pillar is the annular and has seted up the spout, the inside slip of spout is provided with cowl, and is connected with the spring between two cowl, be provided with high skin affinity preparation in the holding tank, cowl's upper and lower both sides contact with intermediate pillar and column cap, cowl's top contacts with cowl.
According to the above technical solution, the step of step S3 is:
s1-1, starting the hydraulic pump (61) to pump the phase A in the storage cavity (6) into the spray head (62), wherein the phase A slowly flows down along the semicircular shell (11);
s1-2, rotating the rotary cylinder (4) to enable the rolling post (42) to roll along the outer wall of the semicircular shell (11), and rolling the phase A to enable astaxanthin in the through hole to be mixed with the phase A to obtain a phase B;
s1-3, starting a motor (43) to enable an output shaft of the motor to rotate to drive the pressing plate (2) to change the angle, and enabling the nail-shaped teeth (21) to drive the phase B to slide on the arc-shaped shell (12);
s1-4, starting the rotary cylinder (4) to enable the support rod (41) to swing up and down, pressing the arc-shaped baffle (32) downwards, increasing the pressure in the accommodating groove (5), and extruding the high skin affinity preparation from the flexible sleeve (51) into the coating hole (121) to coat the high skin affinity preparation on the phase B.
According to the technical scheme, the filter screen is installed to the inner wall of holding tank.
According to the technical scheme, the distance between the rolling column and the semicircular shell is two centimeters.
According to the technical scheme, the surface of the arc-shaped shell is uniformly coated with the polyurethane lubricating coating.
According to the technical scheme, the rolling column is made of elastic rubber.
Compared with the prior art, the invention has the following beneficial effects: the cleansing oil provided by the invention has the effect of cleaning the face in a multi-level manner, the practicability of matched processing equipment is high, the quality of the cleansing oil obtained by processing can be guaranteed, the coating of the astaxanthin-coated A phase and the high skin affinity preparation is combined, and the working efficiency is improved.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the internal structure of the present invention;
FIG. 3 is a schematic view of a partial structure of the present invention;
in the figure: 1. processing the shell; 11. a semi-circular shell; 12. an arcuate shell; 121. coating the holes; 2. pressing plate; 21. spike-shaped teeth; 3. a middle column; 31. a column cap; 32. an arc-shaped baffle plate; 33. a chute; 34. a spring; 4. a rotary cylinder; 41. a strut; 42. rolling the column; 43. a motor; 5. accommodating grooves; 51. a flexible sleeve; 52. filtering with a screen; 6. a storage chamber; 61. a hydraulic pump; 62. a spray head; 421. a filling head.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, the present invention provides the following technical solutions: a make-up removing oil containing astaxanthin liposome comprises liposome, astaxanthin, and high skin affinity preparation, wherein the skin comprises epidermal layer, stratum corneum, and transparent layer, and has effects of cleaning skin oil stain for multiple times and strengthening active substances; the cleansing oil provided by the invention meets the standard GB/T35914 (type I).
Specifically, the coating comprises the following components in parts by weight: 50-85 parts of cetyl ethyl hexanoate, 5-35 parts of squalane, 0.03-0.1 part of pentaerythritol tetrakis (bis-tert-butyl hydroxy hydrocinnamate), 1.5-4 parts of polyglycerol-6 didecanoate, 5.5-8.5 parts of polyglycerol-2 decanoate, 70-100 parts of liposome, 0.1-1 part of astaxanthin, 0.02-0.07 part of dopamine and 0.3-2 parts of high skin affinity preparation.
Further, the high skin affinity preparation is prepared from a targeting functional substance and bacterial cellulose in a mass ratio of 30-50: 1 in the composition of claim 1.
Still further, the targeting function: according to the mass ratio of 1: 8-13: and 2-5, mixing the tetrahydromethylpyrimidine carboxylic acid, water and the hexacyclic stone micro powder, keeping the temperature at 40-55 ℃, shaking, and heating to 100 ℃ to remove water.
Furthermore, the particle size of the hexacyclic ring stone micro powder is 100-250 μm.
The preparation method of the cleansing oil containing the astaxanthin liposome comprises the following preparation steps:
s1, weighing the raw materials according to the formula;
s2, mixing the obtained cetyl ethyl hexanoate, squalane, pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), polyglycerol-6 didecanoate, polyglycerol-2 decanoate, liposome and dopamine at 45-60 ℃ to obtain a phase A;
s3, mixing astaxanthin with the A phase to obtain a B phase, and coating the high skin affinity preparation on the B phase to obtain the cleansing oil containing astaxanthin liposome.
The process of step S3 employs the following devices: including processing shell (1), processing shell (1) comprises interconnect's semicircle shell (11) and arc shell (12), hydraulic pump (61) are installed to the top inner wall of semicircle shell (11), the inside of processing shell (1) has middle post (3) through welded fastening, revolving cylinder (4) are installed to the one end of middle post (3), revolving cylinder (4) are two of piling up from top to bottom, and the output of two revolving cylinder (4) is connected with branch (41) respectively, the one end of branch (41) has roller post (42) through bearing swing joint, the through-hole has been seted up to the outer wall of roller post (42), and the inside packing of through-hole has astaxanthin, the top of revolving cylinder (4) is connected with column cap (31), the diameter of column cap (31) is the same with middle post (3), and roller post head (421) are installed to the bottom of roller post (42), when the rolling device is used, the rotating cylinder 4 drives the supporting rod 41 to swing, so that the rolling column 42 rolls the high-viscoelasticity phase A pumped by the hydraulic pump 61, the astaxanthin can slowly seep out through the through hole during rolling, and the astaxanthin in the through hole and the phase A can be mixed along with rolling, so that the phase A becomes a thicker layer, the mixing effect is good, and the forming is easier;
one end of the rolling post 42 is fixedly provided with a motor 43 through welding, an output shaft of the motor 43 is connected with a pressing plate 2 through a coupler, nail-shaped teeth 21 are uniformly arranged on one side of the pressing plate 2, the shape of the pressing plate 2 is matched with that of the arc-shaped shell 12, the pressing plate 2 is movably connected with the rolling post 42 through a bearing, the motor 43 is started to enable the nail-shaped teeth 21 to be in contact with A, the A phase is displaced by utilizing the nail-shaped teeth 21, the nail-shaped teeth 21 can poke the A phase into a plurality of holes, the A phase can be thinned through reciprocating displacement of the pressing plate 2, and mixing is enabled to be more sufficient;
one side of the arc-shaped shell 12 is uniformly provided with coating holes 121, one side of the middle column 3 is fixedly provided with a containing groove 5 by welding, one side of the containing groove 5 is correspondingly provided with a flexible sleeve 51, one side of the flexible sleeve 51 is contacted with the inner wall of the arc-shaped shell 12, the outer circumference of the top of the middle column 3 is annularly provided with a chute 33, an arc-shaped baffle plate 32 is arranged inside the chute 33 in a sliding manner, a spring 34 is connected between the two arc-shaped baffle plates 32, a high skin affinity preparation is arranged in the containing groove 5, the upper side and the lower side of the arc-shaped baffle plate 32 are contacted with the middle column 3 and a column head 31, the top of the arc-shaped baffle plate 32 is contacted with the arc-shaped baffle plate 32, the pressure of a cavity of the middle column 3 can be adjusted by utilizing the reciprocating rotation of the supporting rod 41, the arc-shaped baffle plate 32 is drawn close to the middle when rotating downwards, so that the arc-shaped baffle plates 32 are compressed, and the skin affinity preparation in the containing groove 5 is extruded into the flexible sleeve 51 by the pressure, the supply of the preparation with high skin affinity and the extrusion of the phase A are promoted to be synchronously carried out, and the mixing effect is better;
the step of step S3 is:
s1-1, starting the hydraulic pump (61) to pump the phase A in the storage cavity (6) into the spray head (62), wherein the phase A slowly flows down along the semicircular shell (11);
s1-2, rotating the rotary cylinder (4) to enable the rolling post (42) to roll along the outer wall of the semicircular shell (11), and rolling the phase A to enable astaxanthin in the through hole to be mixed with the phase A to obtain a phase B;
s1-3, starting a motor (43) to enable an output shaft of the motor to rotate to drive the pressing plate (2) to change the angle, and enabling the nail-shaped teeth (21) to drive the phase B to slide on the arc-shaped shell (12);
s1-4, starting the rotary cylinder (4) to enable the support rod (41) to swing up and down, and downwards extruding the arc-shaped baffle plate (32) to increase the pressure in the accommodating tank (5), extruding the high-skin-affinity preparation from the flexible sleeve (51) into the coating hole (121) to coat the high-skin-affinity preparation on the phase B, wherein the process can be used for forming the phase A, mixing astaxanthin with the phase A and the high-skin-affinity preparation, so that the three processes are carried out in one station, the situation that the phase A is oxidized to cause insufficient mixing is prevented, and the astaxanthin is better accommodated;
the inner wall of the accommodating tank 5 is provided with a filter screen 52, and the filter screen 52 can prevent the filling liquid inside from flowing back while penetrating air;
the distance between the rolling column 42 and the semicircular shell 11 is two centimeters, and the two centimeters are the recommended thickness of the phase A;
the surface of the arc-shaped shell is uniformly coated with a polyurethane lubricating coating, so that the sliding smoothness of the arc-shaped shell is improved conveniently, and the service life of the arc-shaped shell is prolonged;
the rolling column is made of elastic rubber, so that the rolling column has high elastic deformation capacity and is flexible to use.
Example 1
The cleansing oil containing the astaxanthin liposome comprises the following components in parts by weight: 50 parts of cetyl ethylhexanoate, 5 parts of squalane, 0.03 part of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), 1.5 parts of polyglycerol-6 didecanoate, 5.5 parts of polyglycerol-2 caprate, 70 parts of liposome, 0.1 part of astaxanthin, 0.02 part of dopamine and 0.3 part of a high skin affinity preparation.
The high skin affinity preparation is prepared from a targeting functional substance and bacterial cellulose according to a mass ratio of 30: 1 in the composition of claim 1.
The targeting function: according to the mass ratio of 1: 8: 2, mixing the tetrahydromethylpyrimidine carboxylic acid, water and the hexacyclic stone micro powder, keeping the temperature at 40 ℃, shaking, and heating to 100 ℃ to remove water.
The particle size of the hexacyclic ring stone micro powder is 100-250 mu m.
Example 2
The cleansing oil containing the astaxanthin liposome comprises the following components in parts by weight: 85 parts of cetyl ethylhexanoate, 35 parts of squalane, 0.1 part of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), 4 parts of polyglycerol-6 didecanoate, 8.5 parts of polyglycerol-2 decanoate, 100 parts of liposomes, 1 part of astaxanthin, 0.07 part of dopamine and 2 parts of a high skin affinity preparation.
The high skin affinity preparation is prepared from a targeting functional substance and bacterial cellulose according to a mass ratio of 50: 1 in the composition of claim 1.
The targeting function: according to the mass ratio of 1: 13: 5 mixing the tetrahydromethylpyrimidine carboxylic acid, water and the hexacyclic stone micro powder, keeping the temperature at 55 ℃, shaking, and heating to 100 ℃ to remove water.
The particle size of the hexacyclic ring stone micro powder is 100-250 mu m.
Example 3
The cleansing oil containing the astaxanthin liposome comprises the following components in parts by weight: 75 parts of cetyl ethylhexanoate, 25 parts of squalane, 0.08 part of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), 3 parts of polyglycerol-6 didecanoate, 7.5 parts of polyglycerol-2 decanoate, 90 parts of liposomes, 0.7 part of astaxanthin, 0.06 part of dopamine and 1.2 parts of a high skin affinity preparation.
The high skin affinity preparation is prepared from a targeting functional substance and bacterial cellulose according to a mass ratio of 40: 1 in the composition of claim 1.
The targeting function: according to the mass ratio of 1: 10: 3 mixing the tetrahydromethylpyrimidine carboxylic acid, water and the hexacyclic stone micro powder, keeping the temperature at 50 ℃, shaking, and heating to 100 ℃ to remove water.
The particle size of the hexacyclic ring stone micro powder is 100-250 mu m.
Comparative example 1 was essentially the same protocol as example 1, except that the high skin affinity formulation was absent.
Comparative example 2 is essentially the same as the protocol of example 1, except for the lack of dopamine.
The cleansing oil prepared according to the formulas of examples 1-3 and comparative examples 1 and 2 was used for evaluation of the use effect, the number of persons participating in evaluation was 20, the average scores were shown in the following table, and the results are shown in the following table
The above table shows that the cleansing oil provided by the invention has stable and good trial effect, and the use experience is deteriorated to different degrees when high skin affinity preparations and dopamine components are lacked.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The cleansing oil containing the astaxanthin liposome is characterized by comprising the following components in parts by mass: 50-85 parts of cetyl ethyl hexanoate, 5-35 parts of squalane, 0.03-0.1 part of pentaerythritol tetrakis (bis-tert-butyl hydroxy hydrocinnamate), 1.5-4 parts of polyglycerol-6 didecanoate, 5.5-8.5 parts of polyglycerol-2 decanoate, 70-100 parts of liposome, 0.1-1 part of astaxanthin, 0.02-0.07 part of dopamine and 0.3-2 parts of high skin affinity preparation.
2. The cleansing oil containing astaxanthin liposome according to claim 1, wherein the high skin affinity preparation is prepared by mixing a targeting functional substance and bacterial cellulose in a mass ratio of 30-50: 1 in the composition of claim 1.
3. The cleansing oil containing astaxanthin liposomes according to claim 2, characterized in that the targeting function: according to the mass ratio of 1: 8-13: and 2-5, mixing the tetrahydromethylpyrimidine carboxylic acid, water and the hexacyclic stone micro powder, keeping the temperature at 40-55 ℃, shaking, and heating to 100 ℃ to remove water.
4. The cleansing oil containing astaxanthin-containing liposomes according to claim 3, characterized in that the particle size of the hexacyclic stone micropowder is 100 to 250 μm.
5. A method for preparing the cleansing oil containing astaxanthin-containing liposomes according to any one of claims 1 to 4, characterized in that the method comprises the following steps:
s1, weighing the raw materials according to the formula;
s2, mixing the obtained cetyl ethyl hexanoate, squalane, pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), polyglycerol-6 didecanoate, polyglycerol-2 decanoate, liposome and dopamine at 45-60 ℃ to obtain a phase A;
s3, mixing astaxanthin with the A phase to obtain a B phase, and coating the high skin affinity preparation on the B phase to obtain the cleansing oil containing astaxanthin liposome.
6. The method for preparing the cleansing oil containing astaxanthin liposome according to claim 5, wherein the step S3 adopts the following equipment: comprises a processing shell (1), the processing shell (1) is composed of a semicircular shell (11) and an arc-shaped shell (12) which are connected with each other, a hydraulic pump (61) is installed on the inner wall of the top of the semicircular shell (11), a middle column (3) is fixed inside the processing shell (1) through welding, one end of the middle column (3) is provided with two rotary cylinders (4), the two rotary cylinders (4) are stacked up and down, and the output ends of the two rotary cylinders (4) are respectively connected with a supporting rod (41), one end of the supporting rod (41) is movably connected with a rolling column (42) through a bearing, the outer wall of the rolling column (42) is provided with a through hole, astaxanthin is filled in the through hole, the top of the rotary cylinder (4) is connected with a column cap (31), the diameter of the column head (31) is the same as that of the middle column (3), and the bottom of the rolling column (42) is provided with a pouring head (421).
7. The preparation method of the cleansing oil containing the astaxanthin liposome according to claim 6, wherein a motor (43) is fixed at one end of the rolling column (42) through welding, an output shaft of the motor (43) is connected with a pressing plate (2) through a coupler, spike-shaped teeth (21) are uniformly arranged on one side of the pressing plate (2), the shape of the pressing plate (2) is matched with that of the arc-shaped shell (12), and the pressing plate (2) is movably connected with the rolling column (42) through a bearing.
8. The method for preparing the cleansing oil containing astaxanthin liposome according to claim 7, it is characterized in that one side of the arc-shaped shell (12) is uniformly provided with coating holes (121), one side of the middle column (3) is fixedly provided with an accommodating groove (5) by welding, one side of the accommodating groove (5) is correspondingly provided with a flexible sleeve (51), one side of the flexible sleeve (51) is contacted with the inner wall of the arc-shaped shell (12), a sliding groove (33) is annularly formed in the peripheral circle of the top of the middle column (3), an arc-shaped baffle (32) is slidably arranged inside the sliding groove (33), and a spring (34) is connected between the two arc-shaped baffles (32), a preparation with high skin affinity is arranged in the holding tank (5), the upper side and the lower side of the arc-shaped baffle (32) are contacted with the middle column (3) and the column head (31), the top of the arc-shaped baffle (32) is contacted with the arc-shaped baffle (32).
9. The method for preparing the cleansing oil containing astaxanthin liposome according to claim 8, wherein the specific steps in the step S3 are as follows:
s1-1, starting the hydraulic pump (61) to pump the phase A in the storage cavity (6) into the spray head (62), wherein the phase A slowly flows down along the semicircular shell (11);
s1-2, rotating the rotary cylinder (4) to enable the rolling post (42) to roll along the outer wall of the semicircular shell (11), and rolling the phase A to enable astaxanthin in the through hole to be mixed with the phase A to obtain a phase B;
s1-3, starting a motor (43) to enable an output shaft of the motor to rotate to drive the pressing plate (2) to change the angle, and enabling the nail-shaped teeth (21) to drive the phase B to slide on the arc-shaped shell (12);
s1-4, starting the rotary cylinder (4) to enable the support rod (41) to swing up and down, pressing the arc-shaped baffle (32) downwards, increasing the pressure in the accommodating groove (5), and extruding the high skin affinity preparation from the flexible sleeve (51) into the coating hole (121) to coat the high skin affinity preparation on the phase B.
10. The method for preparing the cleansing oil containing astaxanthin liposomes according to claim 9, wherein a filter screen (52) is installed on the inner wall of the holding tank (5); the distance between the rolling column (42) and the semicircular shell (11) is 2 cm; the surface of the arc-shaped shell is uniformly coated with a polyurethane lubricating coating; the rolling column is made of elastic rubber.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114869814A (en) * | 2022-03-24 | 2022-08-09 | 北京茂思商贸有限公司 | Water-oil dual-cleansing-moistening cleansing oil and preparation process thereof |
CN114887507A (en) * | 2022-05-07 | 2022-08-12 | 成都科建生物医药有限公司 | Liposome preparation device and method suitable for industrial production |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007492A (en) * | 2016-12-26 | 2017-08-04 | 广州市花安堂生物科技有限公司 | A kind of makeup remover and preparation method thereof |
CN110680786A (en) * | 2019-11-13 | 2020-01-14 | 北京红蓝猫生物科技有限公司 | Astaxanthin oil liposome composition and application thereof |
CN111686045A (en) * | 2020-06-02 | 2020-09-22 | 北京致成生物医学科技有限公司 | Skin-tendering facial mask made of plant-derived bacterial cellulose and preparation method of facial mask |
CN112057406A (en) * | 2020-10-26 | 2020-12-11 | 上海典雅生物科技有限公司 | Bicontinuous clear and thorough cleansing oil and preparation method thereof |
CN214182707U (en) * | 2020-12-10 | 2021-09-14 | 珠海忆坤生物医药研究院有限公司 | High-efficient makeup removing oil homogeneity agitating unit |
-
2021
- 2021-09-30 CN CN202111160648.1A patent/CN113712835B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007492A (en) * | 2016-12-26 | 2017-08-04 | 广州市花安堂生物科技有限公司 | A kind of makeup remover and preparation method thereof |
CN110680786A (en) * | 2019-11-13 | 2020-01-14 | 北京红蓝猫生物科技有限公司 | Astaxanthin oil liposome composition and application thereof |
CN111686045A (en) * | 2020-06-02 | 2020-09-22 | 北京致成生物医学科技有限公司 | Skin-tendering facial mask made of plant-derived bacterial cellulose and preparation method of facial mask |
CN112057406A (en) * | 2020-10-26 | 2020-12-11 | 上海典雅生物科技有限公司 | Bicontinuous clear and thorough cleansing oil and preparation method thereof |
CN214182707U (en) * | 2020-12-10 | 2021-09-14 | 珠海忆坤生物医药研究院有限公司 | High-efficient makeup removing oil homogeneity agitating unit |
Non-Patent Citations (1)
Title |
---|
杨安平 等: "虾青素脂质体的制备与表征", 《医药导报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114869814A (en) * | 2022-03-24 | 2022-08-09 | 北京茂思商贸有限公司 | Water-oil dual-cleansing-moistening cleansing oil and preparation process thereof |
CN114887507A (en) * | 2022-05-07 | 2022-08-12 | 成都科建生物医药有限公司 | Liposome preparation device and method suitable for industrial production |
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