CN113710255A - 治疗心力衰竭 - Google Patents

治疗心力衰竭 Download PDF

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Publication number
CN113710255A
CN113710255A CN202080028568.8A CN202080028568A CN113710255A CN 113710255 A CN113710255 A CN 113710255A CN 202080028568 A CN202080028568 A CN 202080028568A CN 113710255 A CN113710255 A CN 113710255A
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China
Prior art keywords
subject
mitochondria
composition
mitochondrial
pab
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Pending
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CN202080028568.8A
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English (en)
Chinese (zh)
Inventor
J.D.麦卡利
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Boston Childrens Hospital
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Boston Childrens Hospital
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Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Publication of CN113710255A publication Critical patent/CN113710255A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN202080028568.8A 2019-02-15 2020-02-14 治疗心力衰竭 Pending CN113710255A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962806473P 2019-02-15 2019-02-15
US62/806,473 2019-02-15
PCT/US2020/018371 WO2020168247A1 (en) 2019-02-15 2020-02-14 Treating heart failure

Publications (1)

Publication Number Publication Date
CN113710255A true CN113710255A (zh) 2021-11-26

Family

ID=72044848

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080028568.8A Pending CN113710255A (zh) 2019-02-15 2020-02-14 治疗心力衰竭

Country Status (7)

Country Link
US (1) US20220160782A1 (https=)
EP (1) EP3923963A4 (https=)
JP (2) JP7769545B2 (https=)
CN (1) CN113710255A (https=)
AU (1) AU2020223358A1 (https=)
CA (1) CA3130213A1 (https=)
WO (1) WO2020168247A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
US11903974B2 (en) * 2015-11-30 2024-02-20 Flagship Pioneering Innovations V, Inc. Methods and compositions relating to chondrisomes from cultured cells
WO2017124037A1 (en) 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
WO2025184537A1 (en) * 2024-03-01 2025-09-04 The Board Of Trustees Of The Leland Stanford Junior University Bio-engineered mitochondria for targeted delivery to cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170151287A1 (en) * 2015-11-30 2017-06-01 Flagship Ventures Management, Inc. Methods and compositions of chondrisomes
CN109152795A (zh) * 2016-01-15 2019-01-04 儿童医学中心公司 线粒体和组合的线粒体试剂的治疗用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007011757A1 (en) 2005-07-14 2007-01-25 Myogen, Inc. Use of inhibitors of the ubiquitin proteasome pathway for increasing contractility of the heart
IL183818A0 (en) 2007-06-10 2007-10-31 Shimon Harpaz Uniformly abrasive confectionery product and process therefor
US20090202606A1 (en) 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
WO2013171752A1 (en) * 2012-05-16 2013-11-21 Minovia Therapeutics Ltd. Compositions and methods for inducing angiogenesis
WO2015073396A1 (en) 2013-11-12 2015-05-21 The Brigham And Women's Hospital, Inc. Growth differentiation factor (gdf) for treatment of diastolic heart failure
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
JP7218897B2 (ja) 2016-11-16 2023-02-07 ルカ・サイエンス株式会社 心不全の治療及び／又は予防に用いるための心筋幹細胞の製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170151287A1 (en) * 2015-11-30 2017-06-01 Flagship Ventures Management, Inc. Methods and compositions of chondrisomes
CN109152795A (zh) * 2016-01-15 2019-01-04 儿童医学中心公司 线粒体和组合的线粒体试剂的治疗用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ADITYA K. KAZA, MD ET AL.,: "Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia/reperfusion", THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 30 April 2017 (2017-04-30) *
DOUGLAS B. COWAN ET AL.: "Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection", PLOS ONE *
JAMES D. MCCULLY ET AL.: "Mitochondrial transplantation for therapeutic use", CLIN TRANS MED *
SITARAM M. EMANI, MD ET AL.: "Autologous mitochondrial transplantation for dysfunction after ischemia-reperfusion injury", THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 30 July 2017 (2017-07-30) *

Also Published As

Publication number Publication date
AU2020223358A1 (en) 2021-09-09
EP3923963A1 (en) 2021-12-22
EP3923963A4 (en) 2022-11-23
JP7769545B2 (ja) 2025-11-13
WO2020168247A1 (en) 2020-08-20
JP2026048627A (ja) 2026-03-17
JP2022519767A (ja) 2022-03-24
CA3130213A1 (en) 2020-08-20
US20220160782A1 (en) 2022-05-26

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