CN113694282A - Manufacturing method of double-roll medical hemodialyzer and dialysis method - Google Patents

Abstract

The invention discloses a manufacturing method of a double-roll medical hemodialyzer and a dialysis method, wherein the dialysis method comprises the following steps: introducing blood to be dialyzed into the dialysis installation cylinder through the blood input port, wherein the blood to be dialyzed flows downwards along the gap of the dialysis membrane roll and flows into the gap of the other dialysis membrane roll; introducing dialysate into one of the dialysis membrane rolls through the dialysate input port, wherein the dialysate flows from outside to inside along the inner cavity of the dialysis membrane roll; wherein a part of the dialysate permeates to the outside of the membrane and is fused with the blood outside the membrane; under the action of negative pressure, the dialysate carries waste in the blood to another dialysis membrane roll; the other part of the dialysate can enter the hollow transition pipe from the transition inlet, flow downwards and flow into the inner cavity of the other dialysis membrane roll from the transition outlet; the dialysate flows from the other dialysis membrane roll to the infusion tube; the dialyzed blood continues to flow downwards and flows out of the blood output port of the dialysis mounting cylinder.

Description

Manufacturing method of double-roll medical hemodialyzer and dialysis method

Technical Field

The invention relates to the field of a dialyzer manufacturing method and a dialysis method, in particular to a manufacturing method and a dialysis method of a double-roll medical hemodialyzer.

Background

The hemodialyzer is called dialyzer for short, is a pipeline and a container for solute exchange between blood and dialysate, and is a key part of hemodialysis. The dialyzer mainly comprises a support structure and a dialysis membrane, wherein the dialysis membrane is an important component of the dialyzer and is a semipermeable membrane which only allows molecules smaller than the pore diameter of the membrane to pass through, and the membrane material is an improved cellulose membrane or a synthetic membrane which can be made into a high-flux dialyzer.

The existing dialyzers consist of hollow fibers, a shell, a sealing layer and a cylinder cover. The dialysis membrane is made into slender hollow fiber bundle, which is placed inside transparent cylindrical casing, and the hollow fiber bundle has two sides sealed with non-toxic medical polyurethane adhesive and fixed to the casing, and has opening outside the sealing layer and outer end screwed with dome cover to form blood chamber and top opening for connecting blood pipeline. The space formed by the dialyzer shell and the sealing layers on the two sides is divided into a blood chamber and a dialysate chamber by a dialysis membrane, and the two chambers are respectively provided with an inlet and an outlet. When the dialysis machine is used, the outlet and the inlet of the blood chamber are respectively connected with the vein and the artery of the blood path, and the flowing direction of the dialysate is opposite to the flowing direction of the blood.

In the existing hemodialyzer, because the diameter of the hollow fiber membrane is small, thorough cleaning is difficult to carry out, so that not only can organic solvents possibly contact with blood to enter a human body and damage the liver, eyeballs, skin and the like of the human body, but also a large amount of water is needed, and the production cost is high.

Disclosure of Invention

The present invention is directed to overcome the above problems and to provide a method for manufacturing a double-roll medical hemodialyzer and a dialysis method.

The purpose of the invention is realized by the following technical scheme:

a method for manufacturing a double-roll medical hemodialyzer comprises the following steps:

preparing a hollow transition pipe, wherein the hollow transition pipe is provided with a transition inlet and a transition outlet which are distributed along the axial direction;

preparing two groups of dialysis membrane rolls, wherein the dialysis membrane rolls are of a structure formed by double layers of membranes, and openings at two ends and the periphery of the structure are sealed; two groups of dialysis membrane rolls are wound on the hollow transition pipe along the axial direction, wherein one port of one group of dialysis membrane rolls is in sealed communication with a transition inlet of the hollow transition pipe, and one port of the other group of dialysis membrane rolls is in sealed communication with a transition outlet of the hollow transition pipe;

step three, preparing a dialysis mounting cylinder, and detaching two cylinder covers from the cylinder body; the two cylinder covers are respectively provided with a blood input port and a blood output port;

step four, putting the hollow transition pipe wound with the dialysis membrane roll into the cylinder; the other port of one dialysis membrane roll is in sealed communication with the dialysate input port of the cylinder, and the other port of the other dialysis membrane roll is in sealed communication with the dialysate output port of the cylinder;

and step five, fixing the two cylinder covers at two ends of the cylinder body.

In a preferred embodiment of the present invention, the method for manufacturing the dialysis membrane roll comprises the steps of:

preparing two strip-shaped membranes;

placing two membranes in an overlapping manner;

sealing two long edges of the two layers of membranes in a bonding mode;

the space between the two layers of membranes forms a flow path for the dialysate.

In a preferred embodiment of the present invention, the flow rate per unit time of the transition inlet is smaller than the flow rate per unit time of the dialysis membrane roll. Thus, the maximum seepage rate and seepage rate can be obtained, and better dialysate filtering effect and hemodialysis effect can be obtained.

In a preferred embodiment of the present invention, each set of the dialysis membrane rolls includes a plurality of dialysis membrane rolls, and the plurality of dialysis membrane rolls are alternately stacked.

In a preferred embodiment of the present invention, a plurality of dialysate input ports and a plurality of dialysate output ports are provided, and the plurality of dialysate input ports and the plurality of dialysate output ports are respectively and uniformly arranged along a circumferential direction;

the number of the transition inlets and the number of the transition outlets are respectively the same as the number of the dialysate input ports and the number of the dialysate output ports.

Through above-mentioned structure, can carry out the transport of multiunit dislysate simultaneously from the dislysate input port input dislysate that the multiunit arranged along the circumferencial direction, can improve dialysis efficiency and obtain better dialysis effect.

According to a preferable scheme of the invention, a supporting block is arranged between the two groups of dialysis membrane rolls, and a circulation hole is formed in the supporting block;

the supporting block is fixedly arranged in the barrel body in a detachable mode.

A method of double-roll medical hemodialysis comprising the steps of:

introducing blood to be dialyzed into the dialysis installation cylinder through the blood input port, wherein the blood to be dialyzed flows downwards along the gap of the dialysis membrane roll and flows into the gap of the other dialysis membrane roll;

introducing dialysate into one of the dialysis membrane rolls through the dialysate input port, wherein the dialysate flows from outside to inside along the inner cavity of the dialysis membrane roll;

wherein, part of the dialysate permeates outside the membrane and is fused with the blood outside the membrane, and the fused mixed liquid continuously flows downwards; under the action of negative pressure, the dialysate carries waste in the blood to another dialysis membrane roll; the other part of the dialysate can enter the hollow transition pipe from the transition inlet, flow downwards along the inner cavity of the hollow transition pipe and flow into the inner cavity of the other dialysis membrane roll from the transition outlet;

the dialysate flows from the other dialysis membrane roll to the infusion tube for subsequent treatment;

the dialyzed blood continues to flow downwards and flows back to the human body from the blood outlet of the dialysis installation cylinder.

In a preferred embodiment of the invention, the flow direction of the blood to be dialyzed in the gaps of the dialysis membrane roll is opposite to the flow direction of the dialysate in the gaps of the dialysis membrane roll.

Compared with the prior art, the invention has the following beneficial effects:

1. the mode through the rolling will dialyse the membrane and roll up the setting in the barrel, when wasing, dialyse the membrane and roll up and can straightly expand, directly to dialyse the inside and outside surface washing that the membrane was rolled up, be favorable to thoroughly washing organic solvent, avoid organic solvent to get into the human body, harm the human body.

2. Two dialysis membrane rolls are respectively rolled in two inner cavities of the cylinder body, two end openings of one dialysis membrane roll are respectively communicated with the dialysate input port and the transition inlet, and two end openings of the other dialysis membrane roll are respectively communicated with the dialysate output port and the transition outlet. The dialysate firstly seeps out of one of the dialysis membrane rolls, is fused with the blood outside the membrane, and then returns to the other dialysis membrane roll, so that impurities in the dialysate can be filtered in the seeping process, and the blood is prevented from being polluted by the impurities.

Drawings

Fig. 1 is a schematic perspective view of a double-roll medical hemodialyzer obtained by the production method of the present invention.

Fig. 2 is a side view of a double-roll medical hemodialyzer obtained by the manufacturing method of the present invention.

Fig. 3 is a sectional view of a double-roll medical hemodialyzer obtained by the production method of the present invention.

Fig. 4 is a schematic perspective exploded view of a double-roll medical hemodialyzer obtained by the manufacturing method of the present invention.

Detailed Description

In order to make those skilled in the art understand the technical solutions of the present invention well, the following description of the present invention is provided with reference to the embodiments and the accompanying drawings, but the embodiments of the present invention are not limited thereto.

Referring to fig. 1 to 4, the method for manufacturing a double-roll medical hemodialyzer in the present embodiment includes the steps of:

firstly, preparing a hollow transition pipe 1, wherein the hollow transition pipe 1 is provided with a transition inlet 1-1 and a transition outlet 1-2 which are distributed along the axial direction.

Step two, preparing two groups of dialysis membrane rolls 2, wherein the dialysis membrane rolls 2 are of a structure formed by double-layer membranes, and openings at two ends and the periphery of the structure are sealed; the manufacturing method of the dialysis membrane roll 2 comprises the following steps: preparing two strip-shaped membranes; placing two membranes in an overlapping manner; sealing two long edges of the two layers of membranes in a bonding mode; the space between the two layers of membranes forms a flow path for the dialysate.

Two groups of dialysis membrane rolls 2 are wound on the hollow transition pipe 1 along the axial direction, wherein one port of one group of dialysis membrane rolls 2 is in sealed communication with the transition inlet 1-1 of the hollow transition pipe 1, and one port of the other group of dialysis membrane rolls 2 is in sealed communication with the transition outlet 1-2 of the hollow transition pipe 1. Wherein the flow rate of the transition inlet 1-1 in unit time is smaller than the flow rate of the dialysis membrane roll 2 in unit time. Thus, the maximum seepage rate and seepage rate can be obtained, and better dialysate filtering effect and hemodialysis effect can be obtained.

Step three, preparing a dialysis mounting cylinder, and detaching two cylinder covers 3 and a cylinder body 4; the two cylinder covers 3 are respectively provided with a blood input port 3-1 and a blood output port 3-2.

Step four, putting the hollow transition tube 1 wound with the dialysis membrane roll 2 into the cylinder 4; the other port of one dialysis membrane roll 2 is in sealed communication with a dialysate input port 4-1 of the cylinder 4, and the other port of the other dialysis membrane roll 2 is in sealed communication with a dialysate output port 4-2 of the cylinder 4.

And step five, fixing the two cylinder covers 3 at two ends of the cylinder body 4.

Referring to fig. 1 to 4, each set of dialysis membrane rolls 2 includes a plurality of dialysis membrane rolls 2, and the plurality of dialysis membrane rolls 2 are alternately stacked.

A plurality of dialysate input ports 4-1 and dialysate output ports 4-2 are arranged, and the plurality of dialysate input ports 4-1 and the plurality of dialysate output ports 4-2 are uniformly arranged along the circumferential direction respectively;

the number of the transition inlets 1-1 and the number of the transition outlets 1-2 are respectively the same as the number of the dialysate inlets 4-1 and the dialysate outlets 4-2.

Through the structure, the dialysate can be input from the multiple groups of dialysate input ports 4-1 arranged along the circumferential direction, and the multiple groups of dialysate can be conveyed simultaneously, so that the dialysis efficiency can be improved, and a better dialysis effect can be obtained.

Referring to fig. 3, a supporting block 5 is arranged between the two dialysis membrane rolls 2, and a circulation hole 5-1 is arranged on the supporting block 5; the supporting block 5 is fixedly arranged in the cylinder 4 in a detachable mode.

Referring to fig. 1-4, the double-roll medical hemodialysis method in the present embodiment includes the steps of:

the blood to be dialyzed is introduced into the dialysis cartridge via the blood inlet 3-1, flows down along the gaps of the dialysis membrane roll 2 and into the gaps of the other dialysis membrane roll 2.

The dialysate is introduced into one of the dialysis membrane rolls 2 through the dialysate input port 4-1, and flows from outside to inside along the inner cavity of the dialysis membrane roll 2.

Wherein, part of the dialysate permeates outside the membrane and is fused with the blood outside the membrane, and the fused mixed liquid continuously flows downwards; under the action of negative pressure, the dialysate carries waste in the blood to another dialysis membrane roll 2; another part of the dialysate can enter the hollow transition pipe 1 from the transition inlet 1-1, flow downwards along the inner cavity of the hollow transition pipe 1 and flow into the inner cavity of another dialysis membrane roll 2 from the transition outlet 1-2;

the dialysate flows from the other dialysis membrane roll 2 to the infusion tube for subsequent treatment.

The dialyzed blood continues to flow downwards and flows back to the human body from the blood output port 3-2 of the dialysis installation cylinder.

The flow direction of the blood to be dialyzed in the gaps of the dialysis membrane roll 2 is opposite to the flow direction of the dialysate in the gaps of the dialysis membrane roll 2.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art will understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (8)

1. A method for manufacturing a double-roll medical hemodialyzer is characterized by comprising the following steps:

preparing a hollow transition pipe, wherein the hollow transition pipe is provided with a transition inlet and a transition outlet which are distributed along the axial direction;

preparing two groups of dialysis membrane rolls, wherein the dialysis membrane rolls are of a structure formed by double layers of membranes, and openings at two ends and the periphery of the structure are sealed; two groups of dialysis membrane rolls are wound on the hollow transition pipe along the axial direction, wherein one port of one group of dialysis membrane rolls is in sealed communication with a transition inlet of the hollow transition pipe, and one port of the other group of dialysis membrane rolls is in sealed communication with a transition outlet of the hollow transition pipe;

step three, preparing a dialysis mounting cylinder, and detaching two cylinder covers from the cylinder body; the two cylinder covers are respectively provided with a blood input port and a blood output port;

step four, putting the hollow transition pipe wound with the dialysis membrane roll into the cylinder; the other port of one dialysis membrane roll is in sealed communication with the dialysate input port of the cylinder, and the other port of the other dialysis membrane roll is in sealed communication with the dialysate output port of the cylinder;

and step five, fixing the two cylinder covers at two ends of the cylinder body.

2. The method of manufacturing a double-roll medical hemodialyzer according to claim 1, wherein the method of manufacturing the dialysis membrane roll comprises the steps of:

preparing two strip-shaped membranes;

placing two membranes in an overlapping manner;

sealing two long edges of the two layers of membranes in a bonding mode;

the space between the two layers of membranes forms a flow path for the dialysate.

3. The method of manufacturing a double-roll medical hemodialyzer according to claim 1, wherein the flow rate per unit time of the transition inlet is less than the flow rate per unit time of the dialysis membrane roll.

4. The method of manufacturing a double-roll medical hemodialyzer according to claim 1, wherein each set of the dialysis membrane rolls comprises a plurality of dialysis membrane rolls, and the plurality of dialysis membrane rolls are alternately stacked.

5. The method of manufacturing a double-roll medical hemodialyzer according to claim 4, wherein a plurality of dialysate input ports and dialysate output ports are provided, and the plurality of dialysate input ports and dialysate output ports are uniformly arranged in a circumferential direction, respectively;

the number of the transition inlets and the number of the transition outlets are respectively the same as the number of the dialysate input ports and the number of the dialysate output ports.

6. The method of claim 1, wherein a support block is disposed between the two dialysis membrane rolls, and the support block is provided with a flow hole;

the supporting block is fixedly arranged in the barrel body in a detachable mode.

7. A method of double-roll medical hemodialysis, comprising the steps of:

introducing blood to be dialyzed into the dialysis installation cylinder through the blood input port, wherein the blood to be dialyzed flows downwards along the gap of the dialysis membrane roll and flows into the gap of the other dialysis membrane roll;

introducing dialysate into one of the dialysis membrane rolls through the dialysate input port, wherein the dialysate flows from outside to inside along the inner cavity of the dialysis membrane roll;

wherein, part of the dialysate permeates outside the membrane and is fused with the blood outside the membrane, and the fused mixed liquid continuously flows downwards; under the action of negative pressure, the dialysate carries waste in the blood to another dialysis membrane roll; the other part of the dialysate can enter the hollow transition pipe from the transition inlet, flow downwards along the inner cavity of the hollow transition pipe and flow into the inner cavity of the other dialysis membrane roll from the transition outlet;

the dialysate flows from the other dialysis membrane roll to the infusion tube for subsequent treatment;

the dialyzed blood continues to flow downwards and flows back to the human body from the blood outlet of the dialysis installation cylinder.

8. The twin-roll medical hemodialysis method of claim 7, wherein the flow of blood to be dialyzed in the gaps of the dialysis membrane roll is opposite to the flow of dialysate in the gaps of the dialysis membrane roll.

Images