CN113694186A - Protein composite formula beneficial to collagen and hyaluronic acid supplementation - Google Patents
Protein composite formula beneficial to collagen and hyaluronic acid supplementation Download PDFInfo
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- CN113694186A CN113694186A CN202111032437.XA CN202111032437A CN113694186A CN 113694186 A CN113694186 A CN 113694186A CN 202111032437 A CN202111032437 A CN 202111032437A CN 113694186 A CN113694186 A CN 113694186A
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- collagen
- hyaluronic acid
- protein
- elastin
- acid supplementation
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 34
- 108010035532 Collagen Proteins 0.000 title claims abstract description 34
- 229920001436 collagen Polymers 0.000 title claims abstract description 34
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 12
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 12
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 12
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 12
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 12
- 230000009286 beneficial effect Effects 0.000 title claims abstract description 7
- 230000009469 supplementation Effects 0.000 title abstract description 4
- 239000002131 composite material Substances 0.000 title description 2
- 102000016942 Elastin Human genes 0.000 claims abstract description 12
- 108010014258 Elastin Proteins 0.000 claims abstract description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002549 elastin Polymers 0.000 claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000881711 Acipenser sturio Species 0.000 claims abstract description 9
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 8
- 235000013305 food Nutrition 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 claims abstract description 6
- 239000004386 Erythritol Substances 0.000 claims abstract description 6
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000014837 Malpighia glabra Nutrition 0.000 claims abstract description 6
- 239000004376 Sucralose Substances 0.000 claims abstract description 6
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 6
- 235000019414 erythritol Nutrition 0.000 claims abstract description 6
- 229940009714 erythritol Drugs 0.000 claims abstract description 6
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 6
- 235000019408 sucralose Nutrition 0.000 claims abstract description 6
- 241000167854 Bourreria succulenta Species 0.000 claims abstract description 3
- 235000019693 cherries Nutrition 0.000 claims abstract description 3
- 239000013589 supplement Substances 0.000 claims description 2
- 241001640002 Malpighia emarginata Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 8
- 240000003394 Malpighia glabra Species 0.000 abstract description 5
- 244000223014 Syzygium aromaticum Species 0.000 abstract description 2
- 229960005188 collagen Drugs 0.000 description 27
- 239000007788 liquid Substances 0.000 description 12
- 238000003756 stirring Methods 0.000 description 9
- 229940068196 placebo Drugs 0.000 description 8
- 239000000902 placebo Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 7
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 6
- 229920001287 Chondroitin sulfate Polymers 0.000 description 6
- 229940059329 chondroitin sulfate Drugs 0.000 description 6
- 230000003796 beauty Effects 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000037303 wrinkles Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000011265 semifinished product Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 102000012422 Collagen Type I Human genes 0.000 description 2
- 108010022452 Collagen Type I Proteins 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- VEVRNHHLCPGNDU-MUGJNUQGSA-O desmosine Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(CC[C@H](N)C(O)=O)=C(CCC[C@H](N)C(O)=O)C(CC[C@H](N)C(O)=O)=C1 VEVRNHHLCPGNDU-MUGJNUQGSA-O 0.000 description 2
- RGXCTRIQQODGIZ-UHFFFAOYSA-O isodesmosine Chemical compound OC(=O)C(N)CCCC[N+]1=CC(CCC(N)C(O)=O)=CC(CCC(N)C(O)=O)=C1CCCC(N)C(O)=O RGXCTRIQQODGIZ-UHFFFAOYSA-O 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 241000252335 Acipenser Species 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000037331 wrinkle reduction Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a protein compound formula beneficial to collagen and hyaluronic acid supplementation. The composition and the weight ratio are that in 25000mg of total weight, 300-500 mg of raja collagen peptide, 5-50 mg of sturgeon protein, 1-5 mg of elastin, 50-300 mg of VC, 50-100 mg of acerola cherry powder, 50-500 mg of fruit concentrated juice, 500-1000 mg of erythritol, 0-200 mg of citric acid, 0-10 mg of sucralose, 0-10 mg of food essence and the balance of water.
Description
The technical field is as follows:
the invention relates to a protein compound formula beneficial to collagen and hyaluronic acid supplementation.
Background art:
in the field of oral cosmetology, collagen products are more on the market, but the quality of the products is uneven, the content of the collagen is less, and the components which can bind the collagen and increase the skin elasticity, such as elastin, are absent, and the important moisturizing factors such as hyaluronic acid and chondroitin sulfate are absent.
Meanwhile, the collagens used as beauty products in the market are all type I collagen, and the collagens have high effective dosage and less obvious clinical effect. The collagen used in the invention is a compound containing a plurality of components such as II type collagen peptide, chondroitin sulfate, hyaluronic acid and the like, and has very low clinical dosage and obvious effect.
The II type collagen peptide compound has various sources, including ray cartilage, sturgeon cartilage and the like, is a compound composition naturally containing II type collagen, hyaluronic acid and chondroitin sulfate, and has a remarkable effect only by using more than 500mg in clinical dosage.
The invention content is as follows:
the invention aims at the problems and provides a protein compound formula which is beneficial to supplementing collagen and hyaluronic acid.
In order to achieve the purpose, the fish collagen peptide food adopts the following technical scheme that the fish collagen peptide food comprises 300-500 mg of ray collagen peptide, 5-50 mg of sturgeon protein, 1-5 mg of elastin, 50-300 mg of VC, 50-100 mg of acerola cherry powder, 50-500 mg of fruit concentrated juice, 500-1000 mg of erythritol, 0-200 mg of citric acid, 0-10 mg of sucralose, 0-10 mg of food essence and the balance of water in 25000mg of total weight.
The preparation method comprises the following steps of,
1. weighing all the raw and auxiliary materials according to the formula, premixing the powder raw and auxiliary materials, and fully dispersing for later use.
2. And (3) putting the premixed powder prepared in the step (1) into a mixing tank, adding water while stirring, fully dissolving, adding the fruit concentrated juice, and fully stirring to obtain a feed liquid.
3. And heating and stirring the feed liquid, cooling, fixing the volume liquid to the required volume, and then storing in a semi-finished product tank.
4. Sterilizing, filling, inspecting, and packaging.
The invention has the beneficial effects that:
the invention compounds II type fish collagen peptide and elastin of multiple sources at the same time, through complementing elastin and collagen, increase the skin elastic tension; because hyaluronic acid and chondroitin sulfate naturally exist in the II-type collagen derived from sturgeons and rajas, the collagen can strongly lock water and keep moisture, so that the skin is full; clinical verification shows that the beauty cream has remarkable effects in maintaining beauty and keeping young, can remarkably reduce wrinkles by more than 25%, reduce large pores by 23%, increase the density of dermis, increase collagen tissues and the like; low molecular weight, more than 90% of the molecular weight is less than 3000Da, more than 40% of the molecular weight is less than 1000Da, and the molecular weight is easy to absorb and utilize.
Elastin is an important constituent of skin, maintains the elasticity of skin, and declines sharply after age 25. The marker components are desmosine and isodesmosine, the elastin raw material selected by the invention is imported from Denmark, and desmosine and isodesmosine are more than 1%.
The loss of collagen can cause skin aging, wrinkles and the like, the selected type II collagen is from sturgeon imported from Denmark and ray imported from French, is naturally rich in chondroitin sulfate and hyaluronic acid, and can effectively reduce more than 25% of wrinkles, reduce more than 23% of large pores, increase the density of dermis, increase collagen tissues and other effects through clinical verification
The invention can simultaneously supplement collagen and elastin, increase chondroitin sulfate and hyaluronic acid which are natural sources, and is clinically verified to be effective for oral cosmetology
The product has low molecular weight, more than 90% is lower than 3000Da, and more than 40% is lower than 1000 Da.
The invention has low clinical effective dose which is only over 500mg per day, but the effective dose of the type I collagen is generally 10000mg plus 5000-
The invention particularly adds a plurality of collagen sources, and the sturgeon-derived product is used as a luxury component for oral beauty and plays a role together with the collagen derived from the ray.
Description of the drawings:
fig. 1 is a graph showing the change of wrinkles in the nasolabial area and around the eyes after the product was taken for 90 days. Wherein Placebo is the Placebo group and the other is the experimental group.
Fig. 2 is a graph of the change in the gross skin pores after 90 days of product administration. Wherein, a is a Placebo Placebo group, and b is an experimental group.
Fig. 3 is a graph showing the change in the thickness of the dermis of the skin 90 days after the product was taken. Wherein Placebo is the Placebo group and the other is the experimental group.
The specific implementation mode is as follows:
example 1
The method comprises the steps of premixing 500mg of weighed skate collagen peptide, 5mg of sturgeon protein, 1mg of elastin, 100mg of VC, 50mg of acerola powder, 1000mg of erythritol, 3mg of sucralose and 5mg of food essence, and fully dispersing for later use. And then putting the prepared premix into a mixing tank, adding 16640mg of purified water while stirring, heating to 50-60 ℃ for full dissolution, adding 100mg of the rest raw and auxiliary material fruit concentrated juice after dissolution, and fully stirring to obtain a feed liquid.
6596mg of water is added into the feed liquid to reach the required constant volume, and then the feed liquid is stored in a semi-finished product tank. And finally, UHT ultra-high temperature sterilization is carried out, the mixture is cooled to 10-20 ℃ in an aseptic tank, and 25ml of the mixture is filled into each bottle at normal temperature in an aseptic mode, inspected and packaged.
Example 2
Pre-mixing and fully dispersing 450mg of weighed skate collagen peptide, 50mg of sturgeon protein, 5mg of elastin, 200mg of VC, 100mg of acerola powder, 150mg of fruit concentrated juice, 800mg of erythritol, 100mg of citric acid, 3mg of sucralose and 6mg of food essence for later use. And then putting the prepared premix into a mixing tank, adding 17140mg of purified water while stirring, heating to 50-60 ℃ for full dissolution, adding 150mg of the rest raw and auxiliary material fruit concentrated juice after dissolution, and fully stirring to obtain a feed liquid.
Adding 5996mg of water into the feed liquid to a constant volume until the volume is required, and then storing the feed liquid in a semi-finished product tank. And finally, UHT ultra-high temperature sterilization is carried out, the mixture is cooled to 10-20 ℃ in an aseptic tank, and 25ml of the mixture is filled into each bottle at normal temperature in an aseptic mode, inspected and packaged.
Example 3
The method comprises the steps of premixing 500mg of weighed skate collagen peptide, 20mg of sturgeon protein, 1mg of elastin, 150mg of VC, 50mg of acerola powder, 100mg of fruit concentrated juice, 1000mg of erythritol, 3mg of sucralose and 5mg of food essence, and fully dispersing for later use. And then putting the prepared premix into a mixing tank, adding 17290mg of purified water while stirring, heating to 50-60 ℃ for full dissolution, adding 100mg of the rest raw auxiliary material fruit concentrated juice, and fully stirring to obtain a feed liquid.
5881mg of water is added into the feed liquid to reach the required constant volume, and then the feed liquid is stored in a semi-finished product tank. And finally, UHT ultra-high temperature sterilization is carried out, the mixture is cooled to 10-20 ℃ in an aseptic tank, and 25ml of the mixture is filled into each bottle at normal temperature in an aseptic mode, inspected and packaged.
Example 4
The 46 women were divided into experimental and placebo groups, with the experimental group consuming example 1 and the placebo group consuming maltodextrin (administered several times a day, in small amounts each time). After 90 days of continuous administration, the results are shown in fig. 1-3, and it can be seen from the observed experimental data that the administration of the experimental group of example 1 reduced skin wrinkles by more than 25%, reduced large pores by 23%, and increased dermal thickness by 10%, indicating that example 1 has significant effects on skin beauty, wrinkle reduction, pore reduction, collagen tissue increase, etc.
Claims (1)
1. A protein compound formula beneficial to supplement of collagen and hyaluronic acid is characterized by comprising, by weight, 25000mg of total weight, 300-500 mg of skate collagen peptide, 5-50 mg of sturgeon protein, 1-5 mg of elastin, 50-300 mg of VC, 50-100 mg of acerola cherry powder, 50-500 mg of fruit concentrated juice, 500-1000 mg of erythritol, 0-200 mg of citric acid, 0-10 mg of sucralose, 0-10 mg of food essence and the balance of water.
Priority Applications (1)
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CN202111032437.XA CN113694186A (en) | 2021-09-03 | 2021-09-03 | Protein composite formula beneficial to collagen and hyaluronic acid supplementation |
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CN202111032437.XA CN113694186A (en) | 2021-09-03 | 2021-09-03 | Protein composite formula beneficial to collagen and hyaluronic acid supplementation |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115812880A (en) * | 2022-12-16 | 2023-03-21 | 青岛中大寰球生物科技有限公司 | Perch protein peptide compound beverage |
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