CN113694173A

CN113694173A - Traditional Chinese medicine composition for treating dysmenorrhea and preparation method and application thereof

Info

Publication number: CN113694173A
Application number: CN202111216963.1A
Authority: CN
Inventors: 王凯
Original assignee: Shandong University
Current assignee: Rizhao Sanqi Medical Health Products Co ltd
Priority date: 2021-10-19
Filing date: 2021-10-19
Publication date: 2021-11-26

Abstract

The invention provides a traditional Chinese medicine composition for treating dysmenorrhea and a preparation method and application thereof, belonging to the technical field of medicines. The traditional Chinese medicine composition comprises the following raw materials: fennel, rose, dried orange peel, angelica dahurica, cinnamon, angelica, dried ginger, scorched hawthorn, mint, perilla leaf, kudzu root, dark plum and liquorice. The traditional Chinese medicine disclosed by the invention is prepared by selecting dozens of traditional Chinese medicine materials with taste, has no toxic or side effect on a human body through reasonable compatibility, and has a good treatment effect on dysmenorrheal patients. Simultaneously has the functions of promoting blood circulation to remove blood stasis, regulating qi to alleviate pain, warming channel and dispelling cold. The raw material medicines are medicinal and edible medicinal materials, are easy to collect and purchase, have simple and convenient preparation process, are safe and reliable, can be taken for a long time even after the dysmenorrhea is cured, have the functions of regulating menstruation and improving the immunity of women, and have good practical application value.

Description

Traditional Chinese medicine composition for treating dysmenorrhea and preparation method and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating dysmenorrhea as well as a preparation method and application thereof.

Background

The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.

The causes of dysmenorrhea are manifested as unsmooth mood, stagnation of qi due to depression of the liver, improper coordination of qi, obstructed blood flow, internal stagnation of stagnant blood, pain due to stagnation, or cold-warm injury to the lower-jiao and uterus. The treatment of the above diseases mainly comprises promoting blood circulation for removing blood stasis, regulating qi-flowing for relieving pain, warming channels for dispelling cold. Clinically, oral analgesics or injections are usually used to treat the above diseases, and acupuncture is used to treat patients.

Because the recovery of dysmenorrhea is slow, it takes a long time to cure the disease, and it is difficult for patients to cooperate with the treatment for a long time, so it is difficult to achieve good treatment effect. Meanwhile, western medicine preparations aiming at relieving pain, such as aspirin, ibuprofen and other anti-inflammatory analgesics, often have toxic and side effects, and drugs such as aspirin and the like easily cause gastric mucosa injury, thereby further influencing the normal life and working quality of patients.

Disclosure of Invention

In order to overcome the technical problems, the invention provides a traditional Chinese medicine composition for treating dysmenorrhea and a preparation method and application thereof. Simultaneously has the functions of promoting blood circulation to remove blood stasis, regulating qi to alleviate pain, warming channel and dispelling cold. The dysmenorrhea can be taken for a long time after being cured, and has the functions of regulating menstruation and improving the immunity of women, thereby having good practical application value.

In order to achieve the technical purpose, the technical scheme adopted by the invention is as follows:

the invention provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following raw materials:

fennel, rose, dried orange peel, angelica dahurica, cinnamon, angelica, dried ginger, scorched hawthorn, mint, perilla leaf, kudzu root, dark plum, turmeric and liquorice.

Wherein, the fennel has pungent taste and warm property; entering liver, kidney, spleen and stomach meridians; dispel cold and alleviate pain, regulate qi and harmonize stomach. Can be used for treating cold hernia with pain in lower abdomen, leucorrhea, abdominal pain, distention, anorexia, and emesis.

The rose flower is sweet, slightly bitter and warm in taste; entering liver and stomach meridians; is used for promoting the circulation of qi, relieving depression, promoting blood circulation and relieving pain. Can be used for treating incoordination between liver and stomach, and swelling and pain due to trauma.

The dried orange peel is pungent and bitter in flavor and warm in nature; it enters spleen and lung meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm.

The angelica dahurica is pungent and warm; it enters stomach, large intestine and lung meridians. Dispel wind and dampness, induce resuscitation and alleviate pain, resolve swelling and expel pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.

Cinnamon is pungent and sweet in flavor and is strongly hot in nature; it enters kidney, spleen, heart and liver meridians. Tonify fire and strengthen yang, dispel cold and alleviate pain, activate blood and dredge meridians. Has antiinflammatory, radioprotective, antitumor, immunity improving, antiasthmatic, and pesticidal effects.

Chinese angelica root, radix Angelicae sinensis is sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation.

Gan Jiang is pungent and hot. It enters spleen, stomach, heart and lung meridians. Has the effects of warming spleen and stomach for dispelling cold, restoring yang and promoting blood circulation, and warming lung and resolving fluid retention.

Charred maslinic acid, sweet and slightly warm. It enters spleen, stomach and liver meridians. Promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating meat food stagnation, gastric cavity distention, dysentery abdominal pain, blood stasis amenorrhea, puerperal blood stasis, heart and abdomen stabbing pain, and hernia pain; hyperlipidemia. The charred fructus crataegi has effects of resolving food stagnation. Can be used for treating food stagnation and diarrhea and dysentery.

Mint is pungent in flavor and cool in nature. It enters lung and liver meridians. Has the functions of dispelling wind heat; clearing head and eyes; relieving sore throat; promoting eruption; relieving depression, etc. Wind-heat exterior syndrome; headache with reddish eyes; swollen and sore throat; measles without adequate eruption; itching due to rash and sinking; hypochondriac pain due to liver depression

Perilla leaf is pungent and warm. It enters lung and spleen meridians. The functions and indications are as follows: relieve exterior syndrome, dispel cold, move qi and harmonize stomach. Can be used for treating common cold due to wind-cold, cough, emesis, and vomiting of pregnancy.

Kudzuvine root is sweet, pungent and neutral. It enters spleen, stomach, lung and bladder meridians. Relieving muscles and reducing fever; performing superficial diagnosis; promoting the production of body fluid to quench thirst; to raise yang and check diarrhea. Fever due to exogenous pathogens; strong pain in the head and neck; the onset of measles; unsmooth eruption; thirst due to epidemic febrile disease; diabetes; diarrhea; dysentery; hypertension; coronary heart disease.

The dark plum is sour and astringent in taste and mild in nature; it enters liver, spleen, lung and large intestine meridians. Has the effects of astringing lung, relieving cough, relieving diarrhea with astringents, relieving ascaris, relieving pain, promoting the production of body fluid, quenching thirst and the like.

Turmeric is pungent, bitter and warm. It enters spleen and liver meridians. Break blood and move qi, dredge meridians to alleviate pain. It is indicated for abdominal fullness and distention, brachialgia, abdominal mass, amenorrhea due to blood stasis, postpartum abdominal pain due to stasis, traumatic injury, carbuncle and swelling.

The liquorice is sweet in taste and mild in nature; it enters spleen, stomach and lung meridians. Harmonize the middle energizer and relieve urgency, moisten lung, remove toxicity, and harmonize the recipe. It is stir-baked to treat weakness of spleen and stomach, poor appetite, abdominal pain, loose stool, fatigue, fever, consumptive lung disease, cough, palpitation, fright epilepsy; unprocessed, indicated for swollen and sore throat, peptic ulcer, abscess, deep-rooted carbuncle, sores and ulcers, relieving toxicity of herbs and food poisoning.

The medicines have no toxic or side effect on human bodies and have good treatment effect on patients with dysmenorrhea. Simultaneously has the functions of promoting blood circulation to remove blood stasis, regulating qi to alleviate pain, warming channel and dispelling cold. And the dysmenorrhea can be taken for a long time after being cured, and has the functions of regulating menstruation and improving the immunity of women. Therefore, it has good practical application value.

In another embodiment of the present invention, the traditional Chinese medicine composition comprises the following components by mass:

2-10 parts of fennel, 2-10 parts of rose, 2-10 parts of dried orange peel, 2-10 parts of angelica dahurica, 2-10 parts of cinnamon, 5-16 parts of angelica, 5-16 parts of dried ginger, 5-16 parts of scorched hawthorn fruit, 6-18 parts of mint, 2-12 parts of perilla leaf, 2-12 parts of kudzu root, 6-18 parts of dark plum fruit, 2-15 parts of turmeric and 2-15 parts of liquorice.

5-8 parts of fennel, 5-8 parts of rose, 5-8 parts of dried orange peel, 5-8 parts of angelica dahurica, 5-8 parts of cinnamon, 10-14 parts of angelica, 10-14 parts of dried ginger, 10-14 parts of scorched hawthorn fruit, 10-14 parts of mint, 5-10 parts of perilla leaf, 5-10 parts of kudzu root, 10-15 parts of dark plum fruit, 6-10 parts of turmeric and 6-10 parts of liquorice.

8 parts of fennel, 8 parts of rose, 8 parts of dried orange peel, 8 parts of angelica dahurica, 8 parts of cinnamon, 10 parts of angelica, 10 parts of dried ginger, 12 parts of scorched hawthorn fruit, 12 parts of mint, 6 parts of perilla leaf, 6 parts of kudzu root, 12 parts of dark plum fruit, 6 parts of turmeric and 6 parts of liquorice.

In a second aspect of the present invention, a preparation method of the above-mentioned traditional Chinese medicine composition is provided, the preparation method comprises:

uniformly mixing fennel, rose, dried orange peel, angelica dahurica and cinnamon according to the mass parts, placing the mixture in a closed container at a cool and dry place, uniformly mixing nine medicinal materials of angelica, dried ginger, scorched hawthorn, mint, perilla leaf, kudzu vine root, dark plum fruit, turmeric and liquorice according to the mass parts, placing the mixture in the closed container at the cool and dry place, respectively taking out the mixture, uniformly mixing the mixture, adding water, decocting and concentrating to obtain the traditional Chinese medicine composition.

Wherein the product is placed in a closed container in a cool and dry place for at least five days, preferably 5-10 days.

The specific method for decocting and concentrating the materials after respectively taking out and mixing the materials evenly comprises the following steps: respectively taking out, mixing, adding 20-30 times of water, decocting for 0.5-2 hr, mixing the two, decocting for 2-4 hr, concentrating to 8-12 times, and filtering to obtain decoction.

The water may be purified water.

In a third aspect of the present invention, an application of the above-mentioned traditional Chinese medicine composition in preparing a traditional Chinese medicine preparation for treating dysmenorrhea is provided.

In a fourth aspect of the present invention, a traditional Chinese medicine preparation for treating dysmenorrhea is provided, wherein the traditional Chinese medicine preparation comprises the above traditional Chinese medicine composition; the Chinese medicinal preparation can be in the form of oral liquid, decoction, pill, capsule, tablet, powder or granule; preferably oral liquid.

Furthermore, the traditional Chinese medicine preparation also comprises pharmaceutically acceptable auxiliary materials. Such adjuvants include, but are not limited to, diluents, coloring agents, sweeteners, antioxidants, and the like.

The beneficial technical effects of one or more technical schemes are as follows:

the invention selects dozens of traditional Chinese medicine materials with taste, has no toxic or side effect on human bodies through reasonable compatibility, and has good treatment effect on dysmenorrheal patients. Simultaneously has the functions of promoting blood circulation to remove blood stasis, regulating qi to alleviate pain, warming channel and dispelling cold. The raw material medicines are medicinal and edible medicinal materials, are easy to collect and purchase, have simple and convenient preparation process, are safe and reliable, can be taken for a long time even after the dysmenorrhea is cured, have the functions of regulating menstruation and improving the immunity of women, and have good practical application value.

Detailed Description

It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise. It is to be understood that the scope of the invention is not to be limited to the specific embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.

The technical solution of the present invention will be described below with specific examples. The raw materials used in the following examples are commercially available and all the equipment used is conventional.

Example 1

A preparation method of a traditional Chinese medicine oral liquid for treating dysmenorrhea comprises the following components:

The preparation method comprises the following steps:

the preparation method comprises the following steps of carrying out compatibility on the selected traditional Chinese medicines according to the compatibility proportion, uniformly mixing five medicines of fennel, rose, dried orange peel, angelica dahurica and cinnamon, putting the five medicines into an iron can, covering and sealing the iron can, placing the iron can in a cool and dry place for 5 days, uniformly mixing nine medicines of angelica, dried ginger, scorched hawthorn fruit, mint, perilla leaf, radix puerariae, turmeric, dark plum and liquorice, putting the iron can, covering and sealing the iron can, placing the iron can in a cool and dry place for 5 days, respectively taking out the medicines, uniformly mixing, adding 25 times of water, decocting the medicines for one hour, mixing, decocting the medicines for 3 hours, concentrating the medicines to 10 times, filtering the medicine juice, taking out the medicine juice, and finally putting the medicine juice into a container to obtain the traditional Chinese medicine.

Example 2

6 parts of fennel, 6 parts of rose, 6 parts of dried orange peel, 6 parts of angelica dahurica, 6 parts of cinnamon, 12 parts of angelica, 12 parts of dried ginger, 10 parts of scorched hawthorn fruit, 10 parts of mint, 5 parts of perilla leaf, 5 parts of kudzu root, 14 parts of dark plum fruit, 8 parts of turmeric and 8 parts of liquorice.

The preparation method comprises the following steps:

Example 3

10 parts of fennel, 10 parts of rose, 10 parts of dried orange peel, 10 parts of angelica dahurica, 10 parts of cinnamon, 14 parts of angelica, 14 parts of dried ginger, 14 parts of scorched hawthorn fruit, 8 parts of mint, 4 parts of perilla leaf, 4 parts of kudzu root, 8 parts of dark plum fruit, 4 parts of turmeric and 4 parts of liquorice.

The preparation method comprises the following steps:

Comparative example 1

8 parts of fennel, 8 parts of rose, 8 parts of angelica dahurica, 8 parts of cinnamon, 10 parts of dried ginger, 12 parts of scorched hawthorn fruit, 12 parts of mint, 6 parts of kudzu root, 12 parts of dark plum fruit and 6 parts of liquorice.

The preparation method is the same as example 1.

Comparative example 2

8 parts of rose, 8 parts of dried orange peel, 8 parts of angelica dahurica, 8 parts of cinnamon, 10 parts of angelica, 12 parts of scorched hawthorn fruit, 6 parts of perilla leaf, 12 parts of dark plum, 6 parts of turmeric and 6 parts of liquorice.

The preparation method is the same as example 1.

Comparative example 3

15 parts of fennel, 15 parts of rose, 15 parts of dried orange peel, 15 parts of angelica dahurica, 15 parts of cinnamon, 10 parts of angelica, 10 parts of dried ginger, 12 parts of scorched hawthorn fruit, 12 parts of mint, 6 parts of perilla leaf, 6 parts of kudzu root, 12 parts of dark plum fruit, 6 parts of turmeric and 6 parts of liquorice.

The preparation method is the same as example 1.

Effect verification

1. Animal experiments

Research on analgesic effect of dysmenorrheal mice

In order to verify the analgesic effect of the product on dysmenorrhea, the oral liquids of examples 1-3 and comparative examples 1-3 are concentrated and dried in vacuum, and then diluted by adding water (the dilution ratio is 1: 4, W/W) to verify the efficacy of the product based on a mouse primary dysmenorrhea model.

The experimental method comprises the following steps: 42 clean Kunming mice with the weight of 18-22 g are selected, females are randomly divided into 6 groups, and the 6 groups are respectively a blank group, a model group, an example 1 group and a comparative example 1-3 group.

Except for the blank group, the mice of other groups adopt a ethenestrol-oxytocin mode to construct a mouse dysmenorrheal model (see concretely Sunxi swallow, Cao Yongxiao, Liu Jing, and the like. the establishment of the mouse dysmenorrheal model. Chinese pharmacology report 2002(02): 233-. Feeding corresponding medicines on the 7 th day by using the diethylstilbestrol, and feeding equal volume of physiological saline every day for the blank group and the model group; the other groups were administered with a volume of 10ml/kg for 5 days, and were injected with oxytocin into the abdominal cavity 1 hour after the last administration, and the writhing latency and the number of writhing times of the mice were recorded within 30min after the injection.

The experimental results are shown in table 1, compared with the model group and the comparative example group, the group in the example 1 can obviously reduce the writhing frequency (p is less than 0.05) of the mice within 30min, and prolong the latency period of writhing of the dysmenorrheal model of the mice, so that the compound traditional Chinese medicine composition has good analgesic effect.

TABLE 1 mouse writhing response (

n＝7)

2. Clinical trial

All cases were derived from patients diagnosed with primary dysmenorrhea, and 100 selected cases were aged 18-40 years.

10ml of the Chinese medicinal oral liquid provided in example 1 is orally taken by a patient per day for 1 month continuously.

The standard of curative effect refers to the standard of curative effect for diagnosing traditional Chinese medicine diseases, and the diseases are cured: pain disappeared and no recurrence occurred for 3 months; improvement: pain is reduced or eliminated, but not maintained for more than 3 months; the disease is not cured: the pain was not improved.

After taking the oral liquid provided by the embodiment 1 for 1 month, the cure rate is 97 percent, the improvement rate is 3 percent, and a good treatment effect is obtained.

It should be noted that the above-mentioned embodiments are only preferred embodiments of the present invention, and the present invention is not limited thereto, and although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications and equivalents can be made in the technical solutions described in the foregoing embodiments, or equivalents thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. Although the present invention has been described with reference to the specific embodiments, it should be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.

Claims

1. The traditional Chinese medicine composition for treating dysmenorrhea is characterized by comprising the following components in parts by mass:

2. The traditional Chinese medicine composition for treating dysmenorrhea according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by mass:

3. The traditional Chinese medicine composition for treating dysmenorrhea according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by mass:

4. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which comprises the following steps:

5. The method according to claim 4, wherein the product is placed in a closed container in a cool and dry place for not less than five days, preferably 5 to 10 days.

6. The preparation method of claim 4, wherein the specific method of decocting and concentrating with water after respectively taking out and mixing uniformly comprises the following steps: respectively taking out, mixing, adding 20-30 times of water, decocting for 0.5-2 hr, mixing the two, decocting for 2-4 hr, concentrating to 8-12 times, and filtering to obtain medicinal liquid;

the water is purified water.

7. Use of the Chinese medicinal composition of any one of claims 1 to 3 for the preparation of a Chinese medicinal preparation for the treatment of dysmenorrhea.

8. A traditional Chinese medicine preparation for treating dysmenorrhea, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 4.

9. The traditional Chinese medicine preparation according to claim 8, wherein the traditional Chinese medicine preparation is in the form of oral liquid, decoction, pills, capsules, tablets, powder or granules; preferably oral liquid.

10. The traditional Chinese medicine preparation of claim 8, wherein the traditional Chinese medicine preparation further comprises pharmaceutically acceptable excipients.