CN113694130A

CN113694130A - A Chinese medicinal composition for treating diabetic cardiac lesion and preparation method thereof

Info

Publication number: CN113694130A
Application number: CN202111128279.8A
Authority: CN
Inventors: 杨宇峰; 石岩; 李依诺
Original assignee: Liaoning University of Traditional Chinese Medicine
Current assignee: Liaoning University of Traditional Chinese Medicine
Priority date: 2021-09-26
Filing date: 2021-09-26
Publication date: 2021-11-26

Abstract

The invention provides a traditional Chinese medicine composition for treating diabetic cardiac lesion and a preparation method thereof. The four diabetic heart diseases such as coronary heart disease, diabetic cardiomyopathy, cardiac rhythm and cardiac malfunction are treated by taking blood sugar, blood pressure and cardiac function as multiple targets and based on the concept of tonifying qi and yin and activating yang and dissolving stasis. The traditional Chinese medicine composition and the preparation method provided by the application can effectively control blood sugar, improve insulin resistance, and simultaneously can activate yang, discharge turbidity, eliminate phlegm, remove obstruction of qi by removing blood stasis, dredge collaterals, and treat phlegm and blood stasis. The traditional Chinese medicine composition and the preparation method have the advantages of good treatment effect, short treatment course, low cost, simple preparation method and the like.

Description

A Chinese medicinal composition for treating diabetic cardiac lesion and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diabetic cardiac lesions and a preparation method thereof.

Background

Diabetic cardiac disease refers to heart disease complicated or accompanied with diabetes, including coronary atherosclerotic heart disease (coronary heart disease), diabetic cardiomyopathy, and arrhythmia and cardiac dysfunction caused by autonomic nerve disorder, and also including hypertensive heart disease if hypertension exists. Among them, type 2diabetes mellitus (T2 DM) patients account for 90% of the total number of diabetic patients (diabetes mellitus, DM).

Currently, most treatments for diabetes use insulin and antibiotics. Since the treatment of diabetes with insulin and antibiotics, however, approximately 70% to 80% of patients die from cardiovascular complications or complications. Diabetic heart disease usually occurs earlier than non-diabetic patients. In addition, diabetic patients often have painless myocardial infarction with coronary heart disease, and have large infarct area, more wall-through infarctions and higher fatality rate. The existing traditional Chinese medicine preparation for treating diabetic cardiac lesions has the problems of poor effect, long course of treatment, poor prognosis and the like due to different prescriptions of people.

Disclosure of Invention

The invention provides a traditional Chinese medicine composition for treating diabetic cardiac lesions and a preparation method thereof, aiming at solving the problem of poor treatment effect of the traditional Chinese medicine preparation for treating diabetic cardiac lesions.

The invention provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from raw materials of astragalus, codonopsis pilosula, honey-fried licorice root, kudzu root, allium macrostemon, cassia twig, pinellia ternate, snakegourd fruit, salvia miltiorrhiza, ligusticum wallichii, coptis chinensis, pseudo-ginseng and schisandra chinensis, wherein the traditional Chinese medicine components in the traditional Chinese medicine composition have the following characteristics:

astragalus root: the category: tonics for deficiency. Nature, flavor and meridian tropism: sweet and warm. It enters lung, spleen, liver and kidney meridians. The functional indications are as follows: replenishing qi to strengthen superficies, arresting sweating, promoting granulation, inducing diuresis to alleviate edema. Research shows that astragalus polysaccharide has the functions of strengthening heart and expanding blood vessels, expanding peripheral blood vessels of the whole body and promoting skin circulation, and astragalus also has the function of reducing blood sugar.

Codonopsis pilosula: the category: tonics for deficiency. Nature, flavor and meridian tropism: sweet and neutral. It is entered into spleen and lung. The functional indications are as follows: tonify qi of spleen and lung, nourish blood, promote the production of body fluid. Research shows that the Codonopsis pilosula extract has the functions of treating heart failure, regulating blood cell growth, strengthening hematopoiesis, inhibiting platelet aggregation, etc.

Honey-fried licorice root: the category: tonics for deficiency. Nature, flavor and meridian tropism: ping and gan enter stomach, heart, lung and spleen meridians. The functional indications are as follows: nourish yin and blood, tonify qi and activate yang, recover pulse and stop palpitation. Research shows that the licorice total flavone is the main material basis of licorice in resisting arrhythmia, protecting cardiac muscle and possessing obvious myocardial ischemia resisting activity and excellent treating effect on arrhythmia caused by ischemia re-perfusion, low potassium content, low magnesium content, etc.

Kudzu root: the category: exterior-releasing herbs. Nature, flavor and meridian tropism: sweet, pungent and cool. It enters spleen, stomach and lung meridians. The functional indications are as follows: expelling pathogenic factors from muscles and skin, bringing down fever, promoting eruption, promoting the production of body fluid, quenching thirst, invigorating yang, and relieving diarrhea. Research shows that puerarin is widely applied to cardiovascular and cerebrovascular diseases clinically, and has certain curative effects on arrhythmia resistance, cerebral vessel dilation, blood flow increase and the like.

And (3) allium macrostemon: the category: the drugs for regulating qi. Nature, flavor and meridian tropism: pungent, bitter and warm. It enters lung, stomach and large intestine meridians. The functional indications are as follows: activate yang and dissipate nodulation, move qi and remove stagnation. The existing research shows that the allium macrostemon has various pharmacological effects of enhancing immunity, protecting against myocardial injury, reducing blood fat, resisting tumor, relieving asthma, resisting oxidation, resisting relevant inflammation of blood platelet, dilating blood vessel, inhibiting blood coagulation and thrombosis, resisting bacteria, inhibiting liver drug enzyme, and the like.

Cassia twig: the category: exterior-releasing herbs. Nature, flavor and meridian tropism: pungent, sweet and warm; it enters heart, lung and bladder meridians. The functional indications are as follows: induce sweating to relieve muscles, warm and dredge meridians, strengthen yang to transform qi, and smooth the flow of qi. The Benjing Shu Zheng (the sparse meridians): gui Zhi can promote joint movement, warm meridians and unblock collaterals, so it is also indicated for its action.

Pinellia ternata: the category: phlegm-resolving, cough-relieving and asthma-relieving herbs. Nature, flavor and meridian tropism: pungent and warm. It enters spleen, stomach and lung meridians. The functional indications are as follows: dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation. The study shows that the pinellia ternate and the processed product (ginger processed pinellia ternate) thereof also have the effects of resisting arrhythmia, increasing coronary flow and protecting the heart from ischemia reperfusion injury and vascular endothelial cell injury.

And (3) snakegourd fruit: the category: phlegm-resolving, cough-relieving and asthma-relieving herbs. Nature, flavor and meridian tropism: sweet, slightly bitter and cold. It enters lung, stomach and large intestine meridians. The functional indications are as follows: clear heat and remove phlegm, relieve chest stuffiness and dissipate nodulation, moisten dryness and smooth intestines. Modern pharmacological studies show that the snakegourd fruit has the effects of expanding coronary arteries, increasing coronary artery flow and the like, and can effectively treat heart failure diseases such as coronary heart disease and arrhythmia.

Red sage root: the category: blood-activating and stasis-resolving herbs. Nature, flavor and meridian tropism: bitter and slightly cold. It enters heart and liver meridians. The functional indications are as follows: dispel stasis and alleviate pain, activate blood and dredge meridians, clear heart fire and relieve restlessness. The effect of the water-soluble component danshensu of the traditional Chinese medicine salvia on the content of the blood capillary and the plasma lactic acid of the salvia miltiorrhiza is observed, the result shows that the water-soluble component danshensu of the salvia miltiorrhiza improves the blood perfusion of the local tissue microcirculation, the change of the content of the plasma lactic acid is related to the degree of the microcirculation disturbance, and the change is one of indexes for reflecting the cell metabolic disturbance. The Saviae Miltiorrhizae radix and tanshinol have effects of improving microcirculation disturbance, and improving metabolism disorder caused by cell ischemia and anoxia. And tanshinone IIA can reduce the level of PIP2 in platelets, thereby playing a role in resisting platelet aggregation.

Ligusticum wallichii: the category: blood-activating and stasis-resolving herbs. Nature, flavor and meridian tropism: pungent and warm; it enters liver, gallbladder and pericardium meridians. The functional indications are as follows: the rhizoma ligustici wallichii, the rhizoma ligustici wallichii total alkaloids and the ligustrazine can reduce the vascular resistance of the anesthetized dog and increase the blood flow volume of the brain, the femoral artery and the lower limb. And ligustrazine can also reduce PIP2 level in platelet, and inhibit 20K protein phosphorylation, thereby inhibiting platelet aggregation and platelet release reaction.

Coptis chinensis: the category: heat-clearing herbs. Nature, flavor and meridian tropism: bitter and cold; it enters heart, spleen, stomach, gallbladder and large intestine meridians. The functional indications are as follows: clear heat and dry dampness, purge fire and remove toxicity. The berberine can promote AMPK phosphorylation, thereby activating AMPK/GLUT4 signal pathway, promoting glucose uptake ability of cells, and improving insulin resistance of diabetes.

Pseudo-ginseng: the category: hemostatic. Nature, flavor and meridian tropism: sweet, slightly bitter and warm. It enters liver and stomach meridians. The functional indications are as follows: disperse blood stasis, stop bleeding, resolve swelling and alleviate pain. Modern researches show that effective components in pseudo-ginseng, such as pseudo-ginseng saponin, pseudo-ginseng diol glycoside, pseudo-ginseng triol glycoside and the like, in pseudo-ginseng can effectively reduce myocardial autonomy, slow down conduction speed, prolong the effective refractory period and action potential time of a heart, block a slow calcium channel and obviously reduce slow inward current, wherein the pseudo-ginseng saponin can inhibit NF-kB activation in neutrophils, reduce the generation of adhesion molecules such as intercellular adhesion molecules-1 (ICAM-1) and the like in the cells and the infiltration of the neutrophils, further block the occurrence of myocardial ischemia-reperfusion injury, and has the effect of protecting the myocardium.

Schisandra chinensis: the category: astringe the herbs. Nature, flavor and meridian tropism: sour, sweet and warm in nature. It enters lung, heart and kidney meridians. The functional indications are as follows: astringe to arrest discharge, benefit qi and promote the production of body fluid, tonify kidney and calm heart. Research shows that the schisandra chinensis extract and the mulberry leaf extract can inhibit in-vivo thrombosis and platelet aggregation through a damage IV way, have obvious synergistic action and can effectively treat myocardial diseases such as myocardial ischemia reperfusion injury and the like.

In the traditional Chinese medicine composition for treating diabetic cardiac lesion provided by the application, the raw materials for preparing the traditional Chinese medicine composition comprise, by weight, 45-55 parts of astragalus membranaceus, 20-30 parts of codonopsis pilosula, 25-35 parts of honey-fried licorice roots, 25-35 parts of kudzu roots, 10-20 parts of allium macrostemon, 25-35 parts of cassia twig, 10-20 parts of pinellia ternate, 10-20 parts of snakegourd fruits, 15-25 parts of salvia miltiorrhiza, 15-25 parts of ligusticum wallichii, 15-25 parts of coptis chinensis, 5-15 parts of pseudo-ginseng and 5-15 parts of schisandra chinensis. Preferably, the preparation raw materials of the traditional Chinese medicine composition comprise, by weight, 48-52 parts of astragalus membranaceus, 22-28 parts of codonopsis pilosula, 28-32 parts of honey-fried licorice roots, 28-32 parts of kudzu roots, 10-20 parts of allium macrostemon, 28-32 parts of cassia twig, 12-18 parts of pinellia ternate, 12-18 parts of snakegourd fruits, 18-22 parts of salvia miltiorrhiza, 18-22 parts of ligusticum wallichii, 18-22 parts of coptis chinensis, 8-12 parts of pseudo-ginseng and 8-12 parts of schisandra chinensis. Most preferably, the preparation raw materials of the traditional Chinese medicine composition comprise, by weight, 50 parts of astragalus membranaceus, 25 parts of codonopsis pilosula, 30 parts of honey-fried licorice root, 30 parts of radix puerariae, 15 parts of allium macrostemon, 30 parts of cassia twig, 15 parts of pinellia ternate, 15 parts of trichosanthes kirilowii maxim, 20 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of coptis chinensis, 10 parts of pseudo-ginseng and 10 parts of schisandra chinensis. The traditional Chinese medicine composition is prepared from the raw materials of, by weight, 30 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 30 parts of honey-fried licorice root, 30 parts of kudzuvine root, 30 parts of allium macrostemon, 10 parts of cassia twig, 15 parts of pinellia ternate, 30 parts of snakegourd fruit, 30 parts of salvia miltiorrhiza, 5 parts of ligusticum wallichii, 15 parts of coptis chinensis, 9 parts of pseudo-ginseng and 9 parts of schisandra chinensis.

In the traditional Chinese medicine composition for treating diabetic cardiac lesion provided by the application, the traditional Chinese medicine composition can be in various dosage forms such as capsules, decoction or granules.

The application also provides a preparation method of the traditional Chinese medicine composition for treating diabetic cardiac lesion, and the preparation method of the traditional Chinese medicine composition comprises the following steps:

s01: mixing radix astragali, radix Glycyrrhizae Preparata, radix Puerariae, Bulbus Allii Macrostemi, ramulus Cinnamomi, rhizoma Pinelliae, fructus Trichosanthis, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, Coptidis rhizoma, Notoginseng radix, and fructus Schisandrae, adding 70% ethanol, reflux-extracting twice, and mixing extractive solutions to obtain filtrate A.

Mixing prepared radix astragali, radix Glycyrrhizae Preparata, radix Puerariae, Bulbus Allii Macrostemi, ramulus Cinnamomi, rhizoma Pinelliae, fructus Trichosanthis, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, Coptidis rhizoma, Notoginseng radix, and fructus Schisandrae, adding into 70% ethanol solution, extracting under reflux twice, and mixing the extractive solutions to obtain filtrate A. Wherein, in the extraction process of the filtrate A, the addition amount of the ethanol is 8 times of the total weight of the astragalus, the honey-fried licorice root, the kudzuvine root, the allium macrostemon, the cassia twig, the pinellia tuber, the snakegourd fruit, the salvia miltiorrhiza, the szechuan lovage rhizome, the coptis chinensis, the pseudo-ginseng and the schisandra chinensis. The time for each reflux extraction was 2 h.

S02: and decompressing the filtrate A, recovering ethanol, and concentrating to obtain thick paste A.

The filtrate A was treated under reduced pressure to recover an ethanol solution. After the ethanol is recovered, the filtrate A is heated and concentrated at the temperature of 40 ℃ to form thick paste A with the relative concentration of 1.10-1.15, and the thick paste A is reserved.

S03: adding radix Codonopsis into 70% ethanol, reflux-extracting twice, and mixing extractive solutions to obtain filtrate B.

Adding the prepared codonopsis pilosula into ethanol with the mass concentration of 70 percent, carrying out reflux extraction twice, and combining the extract obtained by the reflux extraction twice into filtrate B. Wherein, in the extraction process of the filtrate B, the adding amount of the ethanol is 8 times of the weight of the codonopsis pilosula. The time for each reflux extraction was 2 h.

S04: and decompressing the filtrate B, recovering ethanol, and concentrating to obtain thick paste B.

The filtrate B was treated under reduced pressure to recover an ethanol solution. After the ethanol is recovered, the filtrate B is heated and concentrated at the temperature of 40 ℃ to form thick paste B with the relative concentration of 1.10-1.15, and the thick paste B is reserved.

S05: and mixing the thick paste A and the thick paste B, then spray-drying, adding auxiliary materials, granulating and drying to obtain the traditional Chinese medicine granular preparation.

And uniformly mixing the thick paste A and the thick paste B, and then carrying out spray drying treatment. Then adding auxiliary materials into the thick paste A and the thick paste B after spray drying treatment for granulation process to form granular materials. Drying the granular material to obtain the Chinese medicinal granule. Wherein the auxiliary material is calcium carbonate.

The technical scheme provided by the embodiment of the invention can have the following beneficial effects:

the invention provides a traditional Chinese medicine composition for treating diabetic cardiac lesion and a preparation method thereof. The Chinese medicinal composition treats four diabetic heart diseases such as coronary heart disease, diabetic cardiomyopathy, cardiac rhythm and cardiac malfunction by taking blood sugar, blood pressure and cardiac function as multiple targets and based on the concept of tonifying qi and yin and activating yang to dissipate blood stasis. Wherein, the astragalus and the codonopsis pilosula tonify qi and invigorate the spleen; prepared licorice and cassia twig supplement heart yang and raise yang to transform qi; the coptis root clears heat and dries dampness, and purges fire and detoxifies; the pseudo-ginseng and the Chinese magnoliavine fruit have the effects of tonifying qi, activating blood circulation, promoting blood circulation and relieving pain; the combination of the astragalus and the codonopsis pilosula has the effects of tonifying qi and yin, activating yang and dissolving stasis. The combination of the kudzuvine root, the salvia miltiorrhiza and the Szechuan lovage rhizome can promote blood circulation to remove blood stasis, and tonify qi and dredge collaterals. The snakegourd fruit can promote qi circulation, dissipate stagnation, relieve gastrointestinal phlegm-heat in chest, wash dirty and greasy in chest, eliminate phlegm, descend qi, sooth liver, dispel stagnated heat, guide phlegm and moisten dryness; the allium macrostemon can be pungent and warm, smooth and free, activate yang, dissipate stagnation, expel phlegm turbidity with bitter taste, eliminate upper, middle and lower cold stagnation, and is matched with the two medicines to expel the obstruction of qi, treat yin cold coagulation, and remove obstruction of qi in the chest and yang, and is a key medicine for treating obstruction of qi in the chest caused by cold phlegm stagnation and chest yang deficiency; ban Xia can dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, clear stuffiness and dissipate nodulation, and mainly dispel phlegm and accumulate stagnation of arthralgia. The combination of the three medicines of the snakegourd fruit, the allium macrostemon and the pinellia ternate can spread qi, disperse arthralgia, activate yang, discharge turbidity, promote qi circulation, relieve depression, activate yang, dissipate stagnation, eliminate phlegm and widen chest.

In addition, modern researches show that trichosanthes kirilowii contains organic acids such as trichosanthes kirilowii acid and sterols such as 7-stigmasten-3 beta-alcohol, protects cardiac muscle cells by regulating blood sugar and blood fat, and increases coronary flow by regulating blood pressure. Bulbus Allii Macrostemi contains more sulfur-containing compounds, and also contains main active ingredients such as saponin, nitrogen-containing compound, and acidic substance, and has antioxidant, antiplatelet activity, and wide antitumor, antibacterial, and vascular endothelium protecting effects. Ginsenoside can improve hyperglycemia by regulating glucose absorption, interfering glucose transport and/or glucose treatment, and changing insulin secretion and combination. The berberine can promote AMPK phosphorylation, thereby activating AMPK/GLUT4 signal pathway, promoting glucose uptake ability of cells, and improving insulin resistance of diabetes. Therefore, the snakegourd fruit, the allium macrostemon and the pinellia ternate can obviously improve the clinical symptoms of the coronary atherosclerotic heart disease.

The traditional Chinese medicine composition and the preparation method provided by the application can effectively control blood sugar, improve insulin resistance, and simultaneously can activate yang, discharge turbidity, eliminate phlegm, remove obstruction of qi by removing blood stasis, dredge collaterals, and treat phlegm and blood stasis. The traditional Chinese medicine composition and the preparation method have the advantages of good treatment effect, short treatment course, low cost, simple preparation method and the like.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.

Detailed Description

In clinical practice, the diabetic heart disease is divided into four stages of depression, heat, deficiency and impairment, the diabetic heart disease belongs to serious chronic complications of diabetes, the disease course is advanced to the stage of deficiency and impairment, and the diabetic heart disease is a change of diabetes, the onset of the disease is related to the five zang organs, and the relationship between the disease and the spleen and the kidney is the closest. Therefore, the traditional Chinese medicine composition treats four diabetic heart diseases such as coronary heart disease, diabetic cardiomyopathy, cardiac rhythm and cardiac malfunction by taking blood sugar, blood pressure and cardiac function as multiple targets and based on the concept of tonifying qi and yin and activating yang to dissipate blood stasis. Wherein, the astragalus and the codonopsis pilosula tonify qi and invigorate the spleen; prepared licorice and cassia twig supplement heart yang and raise yang to transform qi; the coptis root clears heat and dries dampness, and purges fire and detoxifies; the pseudo-ginseng and the Chinese magnoliavine fruit have the effects of tonifying qi, activating blood circulation, promoting blood circulation and relieving pain; the combination of the astragalus and the codonopsis pilosula has the effects of tonifying qi and yin, activating yang and dissolving stasis. The combination of the kudzuvine root, the salvia miltiorrhiza and the Szechuan lovage rhizome can promote blood circulation to remove blood stasis, and tonify qi and dredge collaterals. The snakegourd fruit can promote qi circulation, dissipate stagnation, relieve gastrointestinal phlegm-heat in chest, wash dirty and greasy in chest, eliminate phlegm, descend qi, sooth liver, dispel stagnated heat, guide phlegm and moisten dryness; the allium macrostemon can be pungent and warm, smooth and free, activate yang, dissipate stagnation, expel phlegm turbidity with bitter taste, eliminate upper, middle and lower cold stagnation, and is matched with the two medicines to expel the obstruction of qi, treat yin cold coagulation, and remove obstruction of qi in the chest and yang, and is a key medicine for treating obstruction of qi in the chest caused by cold phlegm stagnation and chest yang deficiency; ban Xia can dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, clear stuffiness and dissipate nodulation, and mainly dispel phlegm and accumulate stagnation of arthralgia. The combination of the three medicines of the snakegourd fruit, the allium macrostemon and the pinellia ternate can spread qi, disperse arthralgia, activate yang, discharge turbidity, promote qi circulation, relieve depression, activate yang, dissipate stagnation, eliminate phlegm and widen chest.

The present application provides a Chinese medicinal composition for treating diabetic cardiac diseases and a preparation method thereof, which are described in the following specific examples, but the scope of the present application is not limited thereto.

Example 1

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from 30 parts by weight of astragalus membranaceus, 15 parts by weight of codonopsis pilosula, 30 parts by weight of honey-fried licorice root, 30 parts by weight of kudzuvine root, 30 parts by weight of allium macrostemon, 10 parts by weight of cassia twig, 15 parts by weight of pinellia ternate, 30 parts by weight of snakegourd fruit, 30 parts by weight of salvia miltiorrhiza, 5 parts by weight of ligusticum wallichii, 15 parts by weight of coptis chinensis, 9 parts by weight of pseudo-ginseng and 9 parts by weight of schisandra chinensis.

Based on the above traditional Chinese medicine composition for treating diabetic cardiac lesions provided in the embodiments of the present application, the embodiments of the present application also provide a preparation method of a traditional Chinese medicine composition for treating diabetic cardiac lesions, the method comprising:

s101: mixing prepared radix astragali, radix Glycyrrhizae Preparata, radix Puerariae, Bulbus Allii Macrostemi, ramulus Cinnamomi, rhizoma Pinelliae, fructus Trichosanthis, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, Coptidis rhizoma, Notoginseng radix, and fructus Schisandrae, adding into 70% ethanol solution, extracting under reflux twice, and mixing the extractive solutions to obtain filtrate A. Wherein, in the extraction process of the filtrate A, the addition amount of the ethanol is 8 times of the total weight of the astragalus, the honey-fried licorice root, the kudzuvine root, the allium macrostemon, the cassia twig, the pinellia tuber, the snakegourd fruit, the salvia miltiorrhiza, the szechuan lovage rhizome, the coptis chinensis, the pseudo-ginseng and the schisandra chinensis. The time for each reflux extraction was 2 h.

S102: the filtrate A was treated under reduced pressure to recover an ethanol solution. After the ethanol is recovered, the filtrate A is heated and concentrated at the temperature of 40 ℃ to form thick paste A with the relative concentration of 1.10-1.15, and the thick paste A is reserved.

S103: adding the prepared codonopsis pilosula into ethanol with the mass concentration of 70 percent, carrying out reflux extraction twice, and combining the extract obtained by the reflux extraction twice into filtrate B. Wherein, in the extraction process of the filtrate B, the adding amount of the ethanol is 8 times of the weight of the codonopsis pilosula. The time for each reflux extraction was 2 h.

S104: the filtrate B was treated under reduced pressure to recover an ethanol solution. After the ethanol is recovered, the filtrate B is heated and concentrated at the temperature of 40 ℃ to form thick paste B with the relative concentration of 1.10-1.15, and the thick paste B is reserved.

S105: and uniformly mixing the thick paste A and the thick paste B, and then carrying out spray drying treatment. Then adding auxiliary materials into the thick paste A and the thick paste B after spray drying treatment for granulation process to form granular materials. Drying the granular material to obtain the Chinese medicinal granule. Wherein the auxiliary material is calcium carbonate.

Example 2

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from the following raw materials, by weight, 50 parts of astragalus membranaceus, 25 parts of codonopsis pilosula, 30 parts of honey-fried licorice root, 30 parts of kudzuvine root, 15 parts of allium macrostemon, 30 parts of cassia twig, 15 parts of pinellia ternate, 15 parts of snakegourd fruit, 20 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of coptis chinensis, 10 parts of pseudo-ginseng and 10 parts of schisandra chinensis.

Based on the above traditional Chinese medicine composition for treating diabetic cardiac diseases provided in the embodiments of the present application, the embodiments of the present application also provide a preparation method of a traditional Chinese medicine composition for treating diabetic cardiac diseases, and the specific flow of the method is the same as that in embodiment 1.

Example 3

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from 45 parts by weight of astragalus membranaceus, 20 parts by weight of codonopsis pilosula, 25 parts by weight of honey-fried licorice root, 25 parts by weight of kudzuvine root, 10 parts by weight of allium macrostemon, 25 parts by weight of cassia twig, 10 parts by weight of pinellia ternate, 10 parts by weight of snakegourd fruit, 15 parts by weight of salvia miltiorrhiza, 15 parts by weight of ligusticum wallichii, 15 parts by weight of coptis chinensis, 5 parts by weight of pseudo-ginseng and 5 parts by weight of schisandra chinensis.

Example 4

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from the following raw materials, by weight, 55 parts of astragalus membranaceus, 30 parts of codonopsis pilosula, 35 parts of honey-fried licorice root, 35 parts of kudzuvine root, 20 parts of allium macrostemon, 35 parts of cassia twig, 20 parts of pinellia ternate, 20 parts of snakegourd fruit, 25 parts of salvia miltiorrhiza, 25 parts of ligusticum wallichii, 25 parts of coptis chinensis, 15 parts of pseudo-ginseng and 15 parts of schisandra chinensis.

Example 5

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from raw materials of 48 parts of astragalus membranaceus, 26 parts of codonopsis pilosula, 27 parts of honey-fried licorice root, 31 parts of kudzuvine root, 16 parts of allium macrostemon, 32 parts of cassia twig, 17 parts of pinellia ternate, 18 parts of snakegourd fruit, 21 parts of salvia miltiorrhiza, 21 parts of ligusticum wallichii, 18 parts of coptis chinensis, 12 parts of pseudo-ginseng and 12 parts of schisandra chinensis in parts by weight.

Example 6

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from raw materials of 48 parts by weight of astragalus membranaceus, 22 parts by weight of codonopsis pilosula, 28 parts by weight of honey-fried licorice root, 28 parts by weight of kudzuvine root, 10 parts by weight of allium macrostemon, 28 parts by weight of cassia twig, 12 parts by weight of pinellia ternate, 12 parts by weight of snakegourd fruit, 18 parts by weight of salvia miltiorrhiza, 18 parts by weight of ligusticum wallichii, 18 parts by weight of coptis chinensis, 8 parts by weight of pseudo-ginseng and 8 parts by weight of schisandra chinensis.

Example 7

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from raw materials comprising, by weight, 52 parts of astragalus membranaceus, 28 parts of codonopsis pilosula, 32 parts of honey-fried licorice root, 32 parts of kudzuvine root, 20 parts of allium macrostemon, 32 parts of cassia twig, 18 parts of pinellia ternate, 18 parts of snakegourd fruit, 22 parts of salvia miltiorrhiza, 22 parts of ligusticum wallichii, 22 parts of coptis chinensis, 12 parts of pseudo-ginseng and 12 parts of schisandra chinensis.

Based on the above traditional Chinese medicine composition for treating diabetic cardiac lesions provided in the embodiments of the present application, the embodiments of the present application also provide a preparation method of the traditional Chinese medicine composition for treating diabetic cardiac lesions, and the specific flow of the method package is the same as that in embodiment 1.

Example 8

The embodiment of the application provides a traditional Chinese medicine composition for treating diabetic cardiac lesion, which is prepared from 49 parts by weight of astragalus membranaceus, 24 parts by weight of codonopsis pilosula, 29 parts by weight of honey-fried licorice root, 30 parts by weight of radix puerariae, 16 parts by weight of allium macrostemon, 31 parts by weight of cassia twig, 16 parts by weight of pinellia ternate, 16 parts by weight of fructus trichosanthis, 20 parts by weight of salvia miltiorrhiza, 20 parts by weight of ligusticum wallichii, 20 parts by weight of coptis chinensis, 9 parts by weight of pseudo-ginseng and 9 parts by weight of schisandra chinensis.

In order to illustrate that the traditional Chinese medicine composition for treating diabetic cardiac diseases provided by the embodiments of the present application can be used for treating diabetic cardiac diseases and has good therapeutic effects, the following description is given by way of specific clinical examples.

Clinical example 1

The patient is a woman in a certain week and is 63 years old, the patient has a diabetes history of more than 10 years, and the patient takes 500mg of metformin and acarbose three times a day, so that the blood sugar control is relatively stable. Two months ago, the fasting blood sugar is increased to 9-10mmol/L due to hyperkinesia and tiredness for multiple meals, the heart rate is 105 times per minute in a quiet state, the blood pressure fluctuates between 165 and 210/98 mmHg to 110mmHg, and the reactions of palpitation, dizziness, thirst, profuse sweat and palpitation and shortness of breath are generated, which are expressed as vexation, irritability, poor appetite, dry stool, dark red tongue, white fur and deep and rapid pulse. After the traditional Chinese medicine composition provided by the embodiment 1 of the application is taken for 14 doses, the palpitation symptom is obviously relieved, the shortness of breath and weakness symptom is relieved to some extent, and the fasting blood sugar is 7-8 mmol/L. After the oral liquid is continuously taken for two months, the symptoms basically disappear, and the blood sugar is well controlled.

In conclusion, the traditional Chinese medicine composition provided by the embodiment of the application can effectively treat diabetic cardiac lesions, and has the advantages of good treatment effect, short treatment course, low cost and simple preparation method.

Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure herein. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.

It is to be understood that relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. The present invention is not limited to the precise arrangements that have been described above, and various modifications and changes may be made without departing from the scope thereof. The scope of the invention is limited only by the appended claims.

Claims

1. A traditional Chinese medicine composition for treating diabetic cardiac lesions is characterized in that the traditional Chinese medicine composition is prepared from raw materials of astragalus, codonopsis pilosula, honey-fried licorice root, kudzu root, allium macrostemon, cassia twig, pinellia tuber, snakegourd fruit, salvia miltiorrhiza, ligusticum wallichii, coptis chinensis, pseudo-ginseng and schisandra chinensis.

2. The traditional Chinese medicine composition for treating diabetic cardiac lesion according to claim 1, which is prepared from 45-55 parts by weight of astragalus membranaceus, 20-30 parts by weight of codonopsis pilosula, 25-35 parts by weight of honey-fried licorice root, 25-35 parts by weight of kudzu root, 10-20 parts by weight of allium macrostemon, 25-35 parts by weight of cassia twig, 10-20 parts by weight of pinellia ternate, 10-20 parts by weight of trichosanthes kirilowii maxim, 15-25 parts by weight of salvia miltiorrhiza, 15-25 parts by weight of ligusticum wallichii, 15-25 parts by weight of coptis chinensis, 5-15 parts by weight of pseudo-ginseng and 5-15 parts by weight of schisandra chinensis.

3. The traditional Chinese medicine composition for treating diabetic cardiac lesion according to claim 1, which is prepared from raw materials comprising, by weight, 48-52 parts of astragalus membranaceus, 22-28 parts of codonopsis pilosula, 28-32 parts of honey-fried licorice root, 28-32 parts of kudzu root, 10-20 parts of allium macrostemon, 28-32 parts of cassia twig, 12-18 parts of pinellia ternate, 12-18 parts of trichosanthes kirilowii maxim, 18-22 parts of salvia miltiorrhiza, 18-22 parts of ligusticum wallichii, 18-22 parts of coptis chinensis, 8-12 parts of pseudo-ginseng and 8-12 parts of schisandra chinensis.

4. The traditional Chinese medicine composition for treating diabetic cardiac lesion according to claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition comprise, by weight, 50 parts of astragalus membranaceus, 25 parts of codonopsis pilosula, 30 parts of honey-fried licorice root, 30 parts of kudzu vine root, 15 parts of allium macrostemon, 30 parts of cassia twig, 15 parts of pinellia ternate, 15 parts of snakegourd fruit, 20 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of coptis chinensis, 10 parts of pseudo-ginseng and 10 parts of schisandra chinensis.

5. The traditional Chinese medicine composition for treating diabetic cardiac lesion according to claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition comprise, by weight, 30 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 30 parts of honey-fried licorice root, 30 parts of kudzu vine root, 30 parts of allium macrostemon, 10 parts of cassia twig, 15 parts of pinellia ternate, 30 parts of snakegourd fruit, 30 parts of salvia miltiorrhiza, 5 parts of ligusticum wallichii, 15 parts of coptis chinensis, 9 parts of pseudo-ginseng and 9 parts of schisandra chinensis.

6. The Chinese medicinal composition for treating diabetic cardiac lesions according to claim 1, wherein the preparation of the Chinese medicinal composition comprises capsules, decoctions or granules.

7. A preparation method of a traditional Chinese medicine composition for treating diabetic cardiac lesions is characterized in that the preparation method of the traditional Chinese medicine composition comprises the following steps:

mixing radix astragali, radix Glycyrrhizae Preparata, radix Puerariae, Bulbus Allii Macrostemi, ramulus Cinnamomi, rhizoma Pinelliae, fructus Trichosanthis, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, Coptidis rhizoma, Notoginseng radix, and fructus Schisandrae, adding 70% ethanol, reflux-extracting twice, and mixing extractive solutions to obtain filtrate A;

decompressing the filtrate A, recovering ethanol, and concentrating to obtain thick paste A;

adding radix Codonopsis into 70% ethanol, reflux-extracting twice, and mixing extractive solutions to obtain filtrate B;

decompressing the filtrate B, recovering ethanol, and concentrating to obtain thick paste B;

and mixing the thick paste A and the thick paste B, then spray-drying, adding auxiliary materials, granulating and drying to obtain the traditional Chinese medicine granular preparation.

8. The method of claim 7, wherein during the extraction of the filtrate A, the amount of ethanol added is 8 times of the total weight of the radix astragali, the radix Glycyrrhizae Preparata, the radix Puerariae, the Bulbus Allii Macrostemi, the ramulus Cinnamomi, the rhizoma Pinelliae, the fructus Trichosanthis, the radix Salviae Miltiorrhizae, the rhizoma Chuanxiong, the rhizoma Coptidis, the radix Notoginseng, and the fructus Schisandrae chinensis; in the extraction process of the filtrate B, the addition amount of the ethanol is 8 times of the weight of the codonopsis pilosula.

9. The method for preparing a Chinese medicinal composition for treating diabetic cardiac pathology according to claim 7, wherein the filtrate A is concentrated by heating at 40 ℃ to a thick paste A with a relative concentration of 1.10-1.15; and heating and concentrating the filtrate B at 40 ℃ to obtain thick paste B with the relative concentration of 1.10-1.15.

10. The method of claim 7, wherein the adjuvant is calcium carbonate.