CN113694113A

CN113694113A - Sika deer antler blood particles and preparation method thereof

Info

Publication number: CN113694113A
Application number: CN202111017783.0A
Authority: CN
Inventors: 马秀; 才凤; 马建阳; 冷明君; 秦剑; 王平; 杨光; 尹伊君; 赵洪芸; 吕志强
Original assignee: Liaoning Luyuan Ginseng Pilose Antler Decoction Slices Co ltd
Current assignee: Liaoning Luyuan Ginseng Pilose Antler Decoction Slices Co ltd
Priority date: 2021-09-01
Filing date: 2021-09-01
Publication date: 2021-11-26

Abstract

The invention relates to a sika deer antler blood particle and a preparation method thereof. Belongs to the technical field of deer resource product deep processing. The invention aims to solve the problems that the prior deer blood processing and utilizing method can not completely release bioactive substances, or resources are not fully and reasonably utilized, the resource waste is large, and the like. The sika deer antler blood particles are prepared by extracting sika deer blood, ginseng and wolfberry fruit and adding stevioside into the extract to prepare granules, and have the functions of improving immunity, resisting aging, enriching blood, resisting fatigue, eliminating free radicals in a body and increasing skin elasticity. Dilating blood vessels and removing garbage and toxin in the blood vessels. Preventing coronary heart disease, angina pectoris, coronary arteriosclerosis, etc.

Description

Sika deer antler blood particles and preparation method thereof

Technical Field

The invention belongs to a deep-processed product of deer resources, and particularly relates to a granular preparation prepared from sika deer antler blood and a preparation method thereof.

Background

Deer blood is a famous and precious traditional Chinese medicine, which is originally recorded in Qianjin dietotherapy, and is blood of Cervidae animals, spotted deer and red deer. Since ancient times, the medicine is a treasure for treating diseases and building bodies by royal and sense organs, and a compound product taking the medicine as a main part is called a Xianjia eating Dan prescription. Deer blood is also widely distributed in folks and is regarded as the top grade of traditional Chinese medicine. The recorded records of healthy eating after blood of the deer which is punctured with blood and drank are full in the early Song Dynasty. The Ming Dynasty Li Shizhen made a more detailed study on the medical action of deer blood, and recorded in Ben Cao gang mu as tonifying deficiency, benefiting essence and blood, and removing pox and drug toxicity. And provides a better method for taking the blood between the head and the horn of the deer, wine and drink.

In China, ginseng has historically been regarded as the king of hundred herbs. The Shennong Bencao Jing is the earliest existing monograph in Chinese materia medica, records the essence of ginseng medicine formed before 4000 years in China, and has the effects of tonifying five internal organs, calming the mind, calming soul, stopping palpitation, eliminating pathogenic factors, improving eyesight, and benefiting intelligence. It can be taken for a long time, and has effects of reducing weight and prolonging life. One for each person and one for each ghost. And (4) growing the valley. "

The medlar has a long history of homology of medicine and food, is a famous and precious Chinese medicinal material which is distinguished as the top grade in Shen nong Ben Cao Jing, is called as 'light body and no aging and cold and summer heat resistance after long-time taking', has the efficacy of delaying senility and resisting aging, and is named as 'Laozi'. The medlar contains a plurality of amino acids and special nutrient components such as betaine, zeaxanthin, baccatin and the like, so that the medlar has very good health care effect.

Stevioside is still only used as a natural non-nutritive sweetener to partially replace non-caloric xylitol, mannitol or high-caloric glucose, sucrose, white granulated sugar, sweet orange powder and the like. However, steviol glycosides have a variety of physiological functions. A large number of drug experiments prove that the stevioside has the effects of preventing diabetes, preventing hypertension, preventing tumors, regulating blood fat, inhibiting pathogenic bacteria, promoting mineral absorption and the like. As a bioactive substance with multiple physiological functions, only as a non-nutritive sweetener, is undoubtedly a waste for the multiple effects of steviol glycosides.

The application of deer blood and deer antler blood in medical care at home and abroad has a long history. With the development of society and the progress of science and technology, clinical research and animal comparison experiment verification pharmacological research are carried out by utilizing modern medical means, and the deer blood has the functions of improving the immunologic function, resisting aging, enriching the blood, resisting fatigue and improving the sexual function. According to clinical and experimental researches, the deer blood and the products thereof have good curative effects on anemia, fatigue syndrome, sexual dysfunction, low immune function and the like. Modern scientific research shows that the deer blood is rich in bioactive substances such as polypeptide, human growth hormone, growth factor and the like, and the traditional deer blood processing and utilizing method has the problems that the bioactive substances cannot be completely released, or resources are not fully and reasonably utilized, the resource waste is large and the like.

Disclosure of Invention

l, purpose of the invention: the invention provides sika deer antler blood particles and a production process thereof, and aims to solve the problems that in the existing deer blood processing and utilizing method, bioactive substances cannot be completely released, or resources are not fully and reasonably utilized, the resource waste is large, and the like. As a bioactive substance with multiple physiological functions, only as a non-nutritive sweetener, is undoubtedly a waste for the multiple effects of steviol glycosides.

2. Technical scheme

The sika deer antler blood particle is characterized by being prepared from the following raw materials in parts by weight: 1-5 parts of sika deer blood, 4-20 parts of ginseng, 10-50 parts of wolfberry fruit, 50-250 parts of dextrin and 0.18-0.9 part of stevioside.

A method for preparing the sika deer antler blood granules as claimed in claim 1, wherein the sika deer antler blood granules are prepared by the following steps:

(1) taking fresh deer blood of sika deer, removing impurities, freezing and drying at low temperature to obtain blood powder, taking 1-5 parts of the blood powder, 4-20 parts of ginseng and 10-50 parts of wolfberry fruit as raw materials, adding 3-6 times of water by weight, performing low-temperature ultrasonic extraction for 1 time, wherein the temperature is 30-60 ℃, the ultrasonic frequency is 18-21 kHz, the ultrasonic intensity is 400-1200W, and the time is 20-60 minutes, and the extracting solution and the residual solid phase substance after extraction are reserved for later use;

(2) and (3) placing the rest solid phase substances in the step (1) in a multifunctional extraction tank, carrying out reflux extraction, adding 8-3 times of water of the raw materials respectively, decocting for 3 times, 1-2 h each time, filtering the extracting solution through a filter (80-mesh stainless steel screen), discarding the medicine residues, and combining the 3 times of water decoction into a storage tank for later use.

(3) And (3) combining the extracting solution in the step (1) and the supernatant in the step (2), and carrying out reduced pressure concentration by using a double-effect reduced pressure concentration tank.

Steam pressure: 0.03-0.09 Mpa, temperature: the first effect is 75-85 ℃, the second effect is 60-70 ℃,

vacuum degree: 0.02 to 0.04 MPa for the first effect, 0.06 to 0.08 MPa for the second effect,

the speed of adding the extracting solution is 13-15 kg/min. The relative density of the concentrated solution is more than or equal to 1.02-1.05.

(4) Adding ethanol in an amount which is three times that of the concentrated solution in the step (3), uniformly stirring, standing for 24 hours, filtering, recovering ethanol from filtrate, concentrating the liquid medicine to obtain clear paste with the relative density of more than or equal to 1.05, adding 50-250 parts of dextrin and 0.18-0.9 part of stevioside powder, granulating by adopting a one-step granulation method, grading, subpackaging and packaging.

The preparation method of the sika deer antler blood particles is characterized by comprising the following steps: when the rest solid phase substance is extracted by a multifunctional extraction tank, the selected water is added in an amount which is 6 times, 4 times and 3 times of the weight of the solid phase substance, and the solid phase substance is decocted for 3 times, wherein the time is 2 hours, 1.5 hours and 1 hour respectively.

3 characteristics and effects

The sika deer antler blood particles are taken twice a day, once in the morning and at night and one bag a day, and after being taken, the sika deer antler blood particles can improve the immunity of the organism, enhance the disease resistance, reduce blood pressure and control blood sugar.

The deer blood of the invention-function main treatment: tonify deficiency, nourish blood and replenish essence. Can be used for treating anemia, sexual neurasthenia, and spermatorrhea.

Ginseng-main function indication: has effects in invigorating primordial qi, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing mind. Ginseng, radix Ginseng, is the first essential herb for treating internal injury due to consumptive disease, all the injuries of primordial qi caused by heavy bleeding, profuse sweat, vomiting and diarrhea, can be used singly effectively.

Wolfberry fruit, the main functional indications are: nourish kidney, moisten lung, tonify liver, improve vision. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.

Stevioside has the functions of preventing diabetes, preventing hypertension, preventing tumor, regulating blood fat, inhibiting pathogenic bacteria, promoting mineral absorption, etc.

The invention has the advantages that: the sika deer blood is subjected to low-temperature ultrasonic extraction to convert macromolecular protein into small molecular polypeptide which can be absorbed by human body, so that the biological activity of the sika deer blood is improved. The ginseng and the medlar can effectively crack cell membranes through ultrasonic cracking, so that bioactive substances of the ginseng and the medlar are completely released, and the dissolution rate of effective components of the ginseng and the medlar is effectively improved. Stevioside is used as a bioactive substance with multiple physiological functions, and the traditional method that stevioside is only used as a non-nutritional sweetener is changed, so that the functions of stevioside are fully utilized.

The specific implementation mode is as follows:

the present invention will be described in further detail with reference to examples, but the scope of the present invention is not limited by the examples.

Example one

The preparation method comprises the following steps: the sika deer antler blood particle is characterized by being prepared from the following raw materials in parts by weight: 5 parts of sika deer blood, 20 parts of ginseng, 50 parts of wolfberry fruit, 250 parts of dextrin and 0.9 part of stevioside.

The preparation method of the sika deer antler blood particles comprises the following steps:

(1) taking fresh deer blood of sika deer, removing impurities, freezing and drying at low temperature to obtain blood powder, taking 5 parts of the blood powder, 20 parts of ginseng and 50 parts of medlar as raw materials, adding 3 times of water by weight, performing low-temperature ultrasonic extraction for 1 time at 45 ℃, the ultrasonic frequency of 21kHz, the ultrasonic intensity of 1200W and the time of 50 minutes, and reserving an extracting solution and a residual solid phase substance after extraction for later use;

(2) placing the rest solid phase materials in (1) in a multifunctional extraction tank, reflux-extracting, adding 6 times, 4 times and 3 times of water, decocting for 3 times for 2 hr, 1.5 hr and 1 hr respectively. Filtering the extractive solution with a filter (80 mesh stainless steel screen), discarding the residue, and mixing the 3 decoctions.

Steam pressure: 0.03-0.09 Mpa, temperature: first effect is 75-85 ℃, second effect is 60-70 ℃, and vacuum degree: 0.02-0.04 MPa for the first effect, 0.06-0.08 MPa for the second effect, and 13-15 kg/min for the extracting solution. The relative density of the concentrated liquid phase was 1.05.

(4) Adding ethanol in three times amount into the concentrated solution in the step (3), stirring uniformly, standing for 24h, filtering, recovering ethanol from filtrate, concentrating the liquid medicine to obtain clear paste with the relative density of 1.05, adding 250 parts of dextrin and 0.9 part of stevioside powder, granulating by adopting a one-step granulation method, grading, subpackaging and packaging.

Example two

The preparation method comprises the following steps: the sika deer antler blood particle is characterized by being prepared from the following raw materials in parts by weight: 2 parts of sika deer blood, 8 parts of ginseng, 20 parts of wolfberry fruit, 100 parts of dextrin and 0.36 part of stevioside.

(1) taking fresh deer blood of sika deer, removing impurities, freezing and drying at low temperature to obtain blood powder, taking 2 parts of the blood powder, 8 parts of ginseng and 20 parts of medlar as raw materials, adding 3 times of water by weight, performing low-temperature ultrasonic extraction for 1 time at 45 ℃, the ultrasonic frequency of 21kHz, the ultrasonic intensity of 1000W and the time of 30 minutes, and reserving an extracting solution and a residual solid phase substance after extraction for later use;

the speed of adding the extracting solution is 13-15 kg/min. The relative density of the concentrated liquid was 1.03.

(4) Adding ethanol in an amount which is three times that of the concentrated solution in the step (3), uniformly stirring, standing for 24h, filtering, recovering ethanol from filtrate, concentrating the liquid medicine to obtain clear paste with the relative density of 1.08, adding 100 parts of dextrin and 0.36 part of stevioside powder, granulating by adopting a one-step granulation method, grading, subpackaging and packaging.

EXAMPLE III

The preparation method comprises the following steps: the sika deer antler blood particle is characterized by being prepared from the following raw materials in parts by weight: 4 parts of sika deer blood, 16 parts of ginseng, 40 parts of wolfberry fruit, 200 parts of dextrin and 0.72 part of stevioside.

(1) taking fresh deer blood of sika deer, removing impurities, freezing and drying at low temperature to obtain blood powder, taking 4 parts of the blood powder, 16 parts of ginseng and 40 parts of medlar as raw materials, adding 3 times of water by weight, performing low-temperature ultrasonic extraction for 1 time at 45 ℃, the ultrasonic frequency of 21kHz, the ultrasonic intensity of 1200W and the time of 40 minutes, and reserving an extracting solution and a residual solid phase substance after extraction for later use;

the speed of adding the extracting solution is 13-15 kg/min. The relative density of the concentrated liquid was 1.04.

(4) Adding ethanol in three times amount into the concentrated solution in the step (3), stirring uniformly, standing for 24h, filtering, recovering ethanol from filtrate, concentrating the liquid medicine to obtain clear paste with the relative density of 1.05, adding 200 parts of dextrin and 0.72 part of stevioside powder, granulating by adopting a one-step granulation method, grading, subpackaging and packaging.

Example four

The preparation method comprises the following steps: the sika deer antler blood particle is characterized by being prepared from the following raw materials in parts by weight: 3 parts of sika deer blood, 12 parts of ginseng, 30 parts of wolfberry fruit, 150 parts of dextrin and 0.54 part of stevioside.

(1) taking fresh deer blood of sika deer, removing impurities, freezing and drying at low temperature to obtain blood powder, taking 3 parts of the blood powder, 12 parts of ginseng and 30 parts of medlar as raw materials, adding 3 times of water by weight, performing low-temperature ultrasonic extraction for 1 time at 50 ℃, wherein the ultrasonic frequency is 21kHz, the ultrasonic intensity is 1200W, the time is 50 minutes, and an extracting solution and a solid phase substance left after extraction are reserved for later use;

(5) Adding ethanol in an amount which is three times that of the concentrated solution in the step (3), uniformly stirring, standing for 24h, filtering, recovering ethanol from filtrate, concentrating the liquid medicine to obtain clear paste with the relative density of 1.06, adding 150 parts of dextrin and 0.54 part of stevioside powder, granulating by adopting a one-step granulation method, grading, subpackaging and packaging.

It will be understood that modifications and variations can be made by persons skilled in the art in light of the above teachings and all such modifications and variations are intended to be included within the scope of the invention as defined in the appended claims.

Claims

1. A sika deer antler blood particle is characterized in that: the composition is prepared from the following raw materials in percentage by weight: 1-5 parts of sika deer blood, 4-20 parts of ginseng, 10-50 parts of wolfberry fruit, 50-250 parts of dextrin and 0.18-0.9 part of stevioside.

2. A method for preparing the sika deer antler blood particles as claimed in claim 1, which is characterized in that: the sika deer antler blood granular preparation is prepared by the following steps:

(2) placing the rest solid phase substances in the step (1) in a multifunctional extraction tank, performing reflux extraction, adding 8-3 times of water of the raw materials respectively, decocting for 3 times, 1-2 h each time, filtering the extract through a filter (80-mesh stainless steel screen), discarding the residue, and combining the 3 water decoctions into a storage tank for later use;

(3) mixing the extractive solution of (1) and the supernatant of (2), concentrating under reduced pressure in a double-effect vacuum concentration tank,

adding the extracting solution at a speed of 13-15 kg/min, wherein the relative density of the concentrated solution is more than or equal to 1.02-1.05;

(4) adding ethanol in three times amount into the concentrated solution in the step (3), stirring uniformly, standing for 24h, filtering, and recovering ethanol from the filtrate

Concentrating the liquid medicine to obtain clear paste with the relative density of more than or equal to 1.05, adding 50-250 parts of dextrin and 0.18-0.9 part of stevioside powder, granulating by adopting a one-step granulation method, grading, subpackaging and packaging.

3. The method for preparing sika deer antler blood particles as claimed in claim 2, wherein the method comprises the following steps: when the rest solid phase substance is extracted by a multifunctional extraction tank, the selected water is added in an amount which is 6 times, 4 times and 3 times of the weight of the solid phase substance, and the solid phase substance is decocted for 3 times, wherein the time is 2 hours, 1.5 hours and 1 hour respectively.