CN113693064A - Disinfectant and preparation method and application thereof - Google Patents
Disinfectant and preparation method and application thereof Download PDFInfo
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- CN113693064A CN113693064A CN202111055483.1A CN202111055483A CN113693064A CN 113693064 A CN113693064 A CN 113693064A CN 202111055483 A CN202111055483 A CN 202111055483A CN 113693064 A CN113693064 A CN 113693064A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The invention relates to the technical field of chemical disinfection, and particularly relates to a disinfectant as well as a preparation method and application thereof. The disinfectant comprises the following components in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.5-3.0 parts of surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water. According to the invention, by selecting specific components for matching, the components are matched in a synergistic manner, and the effects of good sterilization effect and high stability of the low-concentration hydrogen peroxide are realized.
Description
Technical Field
The invention relates to the technical field of chemical disinfection, and particularly relates to a disinfectant as well as a preparation method and application thereof.
Background
Disinfection is based on physical, chemical or biological means to eliminate pathogenic microorganisms in various external environments, control other microorganisms causing economic losses, and enable the microorganisms to achieve a harmless treatment method, and drugs with disinfection effects are called disinfectants.
The hydrogen peroxide is a strong oxidant, the aqueous solution is commonly called hydrogen peroxide, is colorless transparent liquid, is an important inorganic chemical product, and is widely applied in the fields of textile, papermaking, chemical industry, light industry, medicine, electronics, food, environmental protection, military industry and the like. Hydrogen peroxide is extremely easily decomposed into oxygen and water, has no residual toxicity, and does not cause secondary pollution to the environment, so the hydrogen peroxide is called as the cleanest disinfectant. Pure hydrogen peroxide has good stability, good storage conditions as long as no impurity is polluted, and can be stored for a long time with little decomposition, but hydrogen peroxide has strong corrosivity, so that the hydrogen peroxide is often in low concentration when in actual use, and the stability of the hydrogen peroxide in low concentration is poor. In the related art, in order to improve the stability of the hydrogen peroxide disinfectant, a method of adding a stabilizer such as inorganic phosphoric acid, sodium silicate, magnesium salt, organic phosphorus, and the like is generally used. However, the stabilizer easily causes environmental pollution, the chelating ability is weakened, and the sterilization effect is reduced; in addition, the conventional hydrogen peroxide disinfectant has the defects of poor stability, corrosion to metal and the like. Therefore, a hydrogen peroxide disinfectant with high stability, environmental friendliness and the like and excellent comprehensive performance is needed.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the inventor provides the disinfectant with good stability, environmental friendliness, strong bactericidal power and basically no corrosiveness and the preparation method thereof.
The technical scheme of the invention is shown as follows.
The invention provides a disinfectant, which comprises the following components in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.5-3.0 parts of surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water.
According to some embodiments of the invention, the surfactant is an anionic surfactant and an amphoteric surfactant.
According to some embodiments of the invention, the disinfecting solution comprises, in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.01-0.5 part of anionic surfactant, 0.5-2.5 parts of amphoteric surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water.
According to some embodiments of the invention, the anionic surfactant is sodium lauroyl hydroxymethylethanesulfonate and the amphoteric surfactant is N-octyl-diaminoethylglycine hydrochloride.
According to some embodiments of the invention, the disinfecting solution comprises, in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.01-0.5 part of sodium lauroyl hydroxymethyl ethanesulfonate, 0.5-2.5 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.05-1.0 part of glycolic acid and 92-98 parts of water.
According to some embodiments of the invention, the disinfecting solution comprises, in parts by weight: 1.5-2.5 parts of hydrogen peroxide, 0.3-1.0 part of N-methyl succinamide, 0.3-1.2 parts of sodium p-pivaloyloxybenzene sulfonate, 0.05-0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 0.8-2.0 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.1-0.5 part of glycolic acid and 92-98 parts of water.
According to some embodiments of the invention, the disinfecting solution comprises, in parts by weight: 1.8-2.2 parts of hydrogen peroxide, 0.4-0.8 part of N-methyl succinamide, 0.5-0.8 part of sodium p-pivaloyloxybenzene sulfonate, 0.1-0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.0-1.5 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.2-0.3 part of glycolic acid and 94-96 parts of water.
The invention also provides a preparation method of the disinfectant, which comprises the following steps:
1) uniformly mixing hydrogen peroxide and water to obtain a solution A;
2) sequentially adding N-methylsuccinamide and sodium p-pivaloyloxybenzene sulfonate into the solution A and uniformly mixing to obtain a solution B;
3) and adding a surfactant and glycolic acid into the solution B and uniformly mixing.
According to some embodiments of the present invention, in the step 1), the mixture is uniformly mixed by stirring, wherein the stirring speed is 50-100 rpm.
According to some embodiments of the present invention, in the step 2), the mixture is uniformly mixed by stirring, wherein the stirring speed is 50-100 rpm.
According to some embodiments of the present invention, in the step 3), the mixture is uniformly mixed by stirring, wherein the stirring speed is 100 to 200 rpm.
The invention also provides the application of the disinfectant or the preparation method of the disinfectant in environmental disinfection.
In another aspect of the present invention, there is also provided a disinfection method comprising contacting a treatment object with the disinfection solution as described above.
According to some embodiments of the present invention, the treatment target is an environment, an appliance, a human body, an animal body, a plant body, or an organic matter.
The invention has the beneficial effects that:
the invention provides a disinfectant, which comprises hydrogen peroxide, N-methyl succinamide, sodium p-pivaloyloxybenzene sulfonate, sodium lauroyl hydroxymethyl ethanesulfonate, N-octyl-diaminoethylglycine hydrochloride, glycolic acid and water; the specific activators of N-methyl succinamide and sodium p-pivaloyloxybenzene sulfonate are added into the hydrogen peroxide, so that the sterilization and disinfection effects of the hydrogen peroxide are enhanced, and the stability of the hydrogen peroxide is greatly improved by adding the specific stabilizers of sodium lauroyl hydroxymethyl ethanesulfonate and glycollic acid. According to the invention, by selecting specific components for matching, the components are matched in a synergistic manner, and the effects of good sterilization effect and high stability of the low-concentration hydrogen peroxide are realized.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The embodiment of the invention provides a disinfectant, which comprises the following components in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.5-3.0 parts of surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water.
According to some embodiments of the invention, the surfactant is an anionic surfactant and an amphoteric surfactant.
According to some embodiments of the invention, the disinfecting solution comprises, in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.01-0.5 part of anionic surfactant, 0.5-2.5 parts of amphoteric surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water.
The inventor finds in research that the low-concentration hydrogen peroxide can remarkably increase the sterilization and disinfection effects by adding a specific activating agent, and the stability of the hydrogen peroxide can be greatly improved and the storage time of the hydrogen peroxide is longer by adding a surfactant and glycolic acid, particularly an anionic surfactant, an amphoteric surfactant and glycolic acid; and the disinfectant of the invention has no corrosion effect on stainless steel or metal products.
According to some embodiments of the invention, the anionic surfactant is sodium lauroyl hydroxymethylethanesulfonate and the amphoteric surfactant is N-octyl-diaminoethylglycine hydrochloride.
According to some embodiments of the invention, the disinfecting solution comprises, in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.01-0.5 part of sodium lauroyl hydroxymethyl ethanesulfonate, 0.5-2.5 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.05-1.0 part of glycolic acid and 92-98 parts of water.
In some preferred embodiments, the disinfecting solution comprises, in parts by weight: 1.5-2.5 parts of hydrogen peroxide, 0.3-1.0 part of N-methyl succinamide, 0.3-1.2 parts of sodium p-pivaloyloxybenzene sulfonate, 0.05-0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 0.8-2.0 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.1-0.5 part of glycolic acid and 92-98 parts of water.
In some more preferred embodiments, the disinfecting solution comprises, in parts by weight: 1.8-2.2 parts of hydrogen peroxide, 0.4-0.8 part of N-methyl succinamide, 0.5-0.8 part of sodium p-pivaloyloxybenzene sulfonate, 0.1-0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.0-1.5 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.2-0.3 part of glycolic acid and 94-96 parts of water.
Hydrogen peroxide is generally prevented from being decomposed by being in a strongly acidic environment, because it is contaminated or gradually decomposed after being stored for a long time. However, hydrogen peroxide itself, as well as acidic solutions, can cause corrosion of metals, greatly limiting their use.
The N-methyl succinamide and sodium p-pivaloyloxybenzene sulfonate are used as activators to improve the disinfection performance of the disinfectant, and lauroyl hydroxymethyl sodium ethanesulfonate, N-octyl-diaminoethylglycine hydrochloride and glycollic acid are used as stabilizers, so that the synergistic effect of the components is realized through the synergistic effect of the components, and the effects of good low-concentration hydrogen peroxide sterilization effect and high stability are realized. The present inventors have also found in the course of their research that the technical effects of the present invention cannot be achieved by any change of the components.
The invention also provides a preparation method of the disinfectant, which comprises the following steps:
1) uniformly mixing hydrogen peroxide and water to obtain a solution A;
2) sequentially adding N-methylsuccinamide and sodium p-pivaloyloxybenzene sulfonate into the solution A and uniformly mixing to obtain a solution B;
3) and adding a surfactant and glycolic acid into the solution B and uniformly mixing.
According to some embodiments of the present invention, in the step 1), the mixture is uniformly mixed by stirring, wherein the stirring speed is 50-100 rpm.
According to some embodiments of the present invention, in the step 2), the mixture is uniformly mixed by stirring, wherein the stirring speed is 50-100 rpm.
According to some embodiments of the present invention, in the step 3), the mixture is uniformly mixed by stirring, wherein the stirring speed is 100 to 200 rpm.
The invention also provides the application of the disinfectant or the preparation method of the disinfectant in environmental disinfection.
In another aspect of the present invention, there is also provided a disinfection method comprising contacting a treatment object with the disinfection solution as described above.
In some embodiments of the present invention, the object to be treated is an environment, an appliance, a human body, an animal body, a plant body, or an organic matter.
In some embodiments, the environment may be a home environment such as a corridor, a bedroom, a bathroom, or an environment in a vehicle such as an automobile, an airplane, or a ship, or a special environment in which a laboratory, an operating room, or a ward must be kept clean, or a breeding environment for raising poultry and livestock, or the like.
In some embodiments, the implement may be a metal implement surface, a non-metal implement surface, or a composite implement surface thereof, or the like.
In some embodiments, the human or animal body is skin, hair, etc. that is in daily contact with the outside world.
In some embodiments, the plant body may be an ornamental plant or the like.
In some embodiments, the organic matter may be human or animal body waste, or remains of plant material, or the like.
In some embodiments, the contact method of the disinfection solution may be spraying, soaking, or the like.
The disinfectant provided by the invention has a good disinfection effect, can kill various pathogenic bacteria, is tasteless, residue-free, non-corrosive to stainless steel, metal products and the like, is harmless to human and animals, has good stability, and is basically neutral or weakly alkaline. The disinfectant of the present invention can produce a sufficient bactericidal effect even when the main component is a small amount, and has a remarkable advantage in safety as well as economical efficiency.
The technical solutions and effects of the present invention will be further described and illustrated with reference to the following specific examples, but the present invention is not limited to these specific embodiments. The test methods used in the examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are commercially available reagents and materials unless otherwise specified.
Hydrogen peroxide CAS: 7722-84-1; n-methyl succinamide CAS: 1121-07-9; sodium p-pivaloyloxybenzene sulfonate CAS: 188114-91-2; sodium lauroyl hydroxymethylethanesulfonate CAS: 928663-45-0; n-octyl-diaminoethylglycine hydrochloride CAS: 36895-38-2; glycolic acid CAS: 79-14-1.
Example 1
Consists of the following components:
6.5 parts of 30 percent hydrogen peroxide, 0.6 part of N-methyl succinamide, 0.6 part of sodium p-pivaloyloxybenzene sulfonate, 0.2 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.2 parts of N-octyl-diamino ethyl glycinate hydrochloride, 0.2 part of glycollic acid and 90.7 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 50rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethylethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and mixing uniformly at 100rpm to obtain the disinfectant 1.
Example 2
Consists of the following components:
6 parts of 30% hydrogen peroxide, 0.8 part of N-methyl succinamide, 0.5 part of sodium p-pivaloyloxybenzene sulfonate, 0.1 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.0 part of N-octyl-diaminoethyl glycine hydrochloride, 0.3 part of glycolic acid and 91.3 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 50rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethyl ethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and mixing uniformly at 100rpm to obtain a disinfectant solution 2.
Example 3
Consists of the following components:
7.2 parts of 30 percent hydrogen peroxide, 0.5 part of N-methyl succinamide, 0.8 part of sodium p-pivaloyloxybenzene sulfonate, 0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.3 parts of N-octyl-diamino ethyl glycinate hydrochloride, 0.2 part of glycollic acid and 89.7 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 50rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethyl ethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and mixing uniformly at 100rpm to obtain a disinfectant solution 3.
Example 4
Consists of the following components:
5 parts of 30% hydrogen peroxide, 0.5 part of N-methyl succinamide, 0.8 part of sodium p-pivaloyloxybenzene sulfonate, 0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.3 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.2 part of glycolic acid and 91.9 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 50rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethylethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and mixing uniformly at 100rpm to obtain a disinfectant solution 4.
Example 5
Consists of the following components:
8.5 parts of 30 percent hydrogen peroxide, 0.4 part of N-methyl succinamide, 0.3 part of sodium p-pivaloyloxybenzene sulfonate, 0.05 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.8 parts of N-octyl-diamino ethyl glycinate hydrochloride, 0.45 part of glycollic acid and 88.5 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 100rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethyl ethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and mixing uniformly at 100rpm to obtain a disinfectant 5.
Example 6
Consists of the following components:
9 parts of 30 percent hydrogen peroxide, 1.5 parts of N-methyl succinamide, 0.3 part of sodium p-pivaloyloxybenzene sulfonate, 0.5 part of sodium lauroyl hydroxymethyl ethanesulfonate, 2.0 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.5 part of glycollic acid and 86.2 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 100rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and uniformly stirring and mixing at 100rpm to obtain a solution B;
3) to the solution B was added sodium lauroyl hydroxymethylethanesulfonate, N-octyl-diaminoethylglycine hydrochloride, glycolic acid and mixed well with stirring at 200 rpm.
Example 7
Consists of the following components:
3.5 parts of 30 percent hydrogen peroxide, 0.3 part of N-methyl succinamide, 1.5 parts of sodium p-pivaloyloxybenzene sulfonate, 0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 0.8 part of N-octyl-diamino ethyl glycinate hydrochloride, 0.1 part of glycollic acid and 93.5 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 100rpm uniformly to obtain a solution A;
2) sequentially adding N-methylsuccinimide and sodium p-pivaloyloxybenzene sulfonate into the solution A, and uniformly stirring and mixing at 100rpm to obtain a solution B;
3) to the solution B was added sodium lauroyl hydroxymethylethanesulfonate, N-octyl-diaminoethylglycine hydrochloride, glycolic acid and mixed well with stirring at 100 rpm.
Comparative example 1
Consists of the following components:
6.5 parts of 30% hydrogen peroxide, 0 part of N-methyl succinamide, 0.6 part of sodium p-pivaloyloxybenzene sulfonate, 0.2 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.2 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.2 part of glycolic acid and 91.3 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 50rpm uniformly to obtain a solution A;
2) adding sodium p-pivaloyloxybenzene sulfonate into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethyl ethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and uniformly mixing at 100rpm to obtain a disinfectant D1.
Comparative example 2
Consists of the following components:
6.5 parts of 30% hydrogen peroxide, 0.6 part of N-methyl succinamide, 0 part of sodium p-pivaloyloxybenzene sulfonate, 0.2 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.2 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.2 part of glycolic acid and 91.3 parts of water.
Preparation:
1) stirring and mixing 30% hydrogen peroxide and water at 50rpm uniformly to obtain a solution A;
2) sequentially adding N-methyl succimide into the solution A, and stirring and mixing uniformly at 80rpm to obtain a solution B;
3) adding sodium lauroyl hydroxymethyl ethanesulfonate, N-octyl-diaminoethyl glycine hydrochloride and glycolic acid into the solution B, and stirring and uniformly mixing at 100rpm to obtain a disinfectant D2.
Comparative example 3
Consists of the following components:
6.5 parts of 30 percent hydrogen peroxide, 0.6 part of N-methyl succinamide, 0.6 part of sodium p-pivaloyloxybenzene sulfonate, 0.2 part of sodium lauroyl hydroxymethyl ethanesulfonate, 1.2 parts of N-octyl-diamino ethyl glycinate hydrochloride, 0.2 part of glycollic acid and 90.7 parts of water.
Preparation:
the lauroyl hydroxymethyl sodium ethanesulfonate, the N-octyl-diamino ethyl glycine hydrochloride, the glycollic acid, the N-methyl succinamide, the sodium p-pivaloyloxybenzene sulfonate, the 30 percent hydrogen peroxide and the water are directly mixed and evenly stirred at 150rpm to obtain the disinfectant D3.
Experimental example:
1. metal corrosivity detection
Metal corrosion test was performed according to Disinfection Specification (2002 edition) 2.2.4
Detection conditions are as follows: ambient temperature 16.2 ℃ and humidity 60% RH.
Three replicates of each sample were run and the final results were averaged and are shown in table 1.
TABLE 1 Metal corrosivity test
2. Detection of hydrogen peroxide content and stability
The hydrogen peroxide content was determined according to the Disinfection Specification (2002 edition) 2.2.1.2.4, and the test was repeated three times for each sample, and the average value was taken;
500mL of disinfectant is filled into a closed container, the container is placed in a thermostat at 54 ℃ for 14 days according to disinfection technical specification (2002 edition) 2.2.3, hydrogen peroxide content stability detection is carried out, three times of tests are repeated on each sample, and an average value is taken;
the results are shown in table 2, in which the hydrogen peroxide reduction rate of the disinfecting solution 1 is the lowest; the hydrogen peroxide reduction rates of the disinfectant solutions 1-7, the disinfectant solution D1 and the disinfectant solution D2 are all within 10%, but the stability of the disinfectant solutions prepared in the examples is generally higher than that of the disinfectant solutions prepared in the comparative examples.
TABLE 2 stability of hydrogen peroxide
3. The sterilizing effect of the disinfectant of the invention
The suspension quantitative bactericidal tests were carried out on Escherichia coli (8099), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) and Pseudomonas aeruginosa (ATCC15442) according to the Disinfection protocol (2002 edition).
The strain providing unit: kyoto Tokay microbial science and technology Co., Ltd;
media and others: nutrient agar medium or Sabouraud's agar medium, phosphate buffer (0.03mol/L pH7.2)
Firstly, preparing a corresponding sample to be tested with the concentration of 1.25 times according to the method of each embodiment/comparative example, and placing the sample to be tested in a water bath at the temperature of 20 +/-1 ℃ for later use.
Preparing bacterial suspension for experiment with physiological saline solution containing 0.1% tryptone, the concentration is 1X 108cfu/ml～5×108cfu/ml。
Taking a large sterile test tube for a disinfection test, adding 1.0ml of test bacterial suspension, adding 4.0ml of prepared 1.25 times concentration disinfectant sample, mixing uniformly, and placing in a water bath at 20 +/-1 ℃; when the test bacteria and the disinfectant interact for each preset time, respectively sucking 0.5ml of mixed solution of the test bacteria and the disinfectant, adding the mixed solution into 4.5ml of sterilized neutralizer (TPS solution of 0.5% sodium thiosulfate, performing a neutralizer verification experiment, effectively neutralizing the action of the residual disinfectant on the surfaces of bacteria on the test bacteria, and enabling the neutralizer and a neutralization product to have no obvious adverse effect on the test bacteria and a culture medium), and uniformly mixing; adding neutralizer into the mixed solution of test bacteria and disinfectant, reacting for 10min, respectively sucking 1.0ml of sample solution, determining viable bacteria number by viable bacteria culture counting method, and inoculating 2 plates to each tube of sample solution. If the number of colonies growing on the plate is large, serial 10-fold dilution can be performed, and viable bacteria culture counting can be performed.
Meanwhile, a dilution (0.1% tryptone physiological saline) was used in place of the disinfectant solution to perform a parallel test as a positive control.
Culturing all test samples in an incubator at 37 ℃, and culturing the bacterial propagules for 48 hours to observe the final result; the bacterial spores were cultured for 72h to observe the final result.
Viable bacteria concentration (cfu/ml) was calculated for each group and converted to log (N), and then log kill was calculated as follows:
log Kill (KL) log of mean viable bacteria concentration of control group (No) -log of viable bacteria concentration of test group (Nx)
When the killing logarithm value is calculated, two place values after the decimal point are taken, and digital trimming can be carried out. If the average number of produced colonies after the disinfection treatment of the disinfection test group is less than or equal to 1, the killing log value is greater than or equal to the log value of the average viable bacteria concentration of the control group before the test.
The test was repeated three times and the results are shown in tables 3 to 6, taking the average. It can be seen that the disinfectant has a very good killing effect on escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa, and can completely kill bacteria within 2.5 min. In the comparative example, after the components or the preparation method of the product are changed, the sterilization effect is still achieved, but the sterilization effect is reduced to a greater extent, and the table shows that the change of the preparation method of the disinfectant has less influence on the sterilization effect than the change of the formula; after the formula is changed, the composition still has a good bactericidal effect on escherichia coli, has a bactericidal effect on staphylococcus aureus, candida albicans and pseudomonas aeruginosa, and basically cannot kill all bacteria within 7.5 min.
TABLE 3 Sterilization effect of different disinfectants on Escherichia coli
TABLE 4 Sterilization effect of different disinfectants on Staphylococcus aureus
TABLE 5 sterilizing effect of different sterilizing liquids on Candida albicans
TABLE 6 sterilizing effect of different sterilizing solutions on pseudomonas aeruginosa
While the invention has been disclosed with reference to specific embodiments, it will be apparent that other embodiments and variations of the invention may be devised by those skilled in the art without departing from the true spirit and scope of the invention, and it is intended that the following claims be interpreted to include all such embodiments and equivalent variations. In addition, the contents of all references cited herein are hereby incorporated by reference.
Claims (10)
1. The disinfectant is characterized by comprising the following components in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.5-3.0 parts of surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water.
2. The disinfecting solution of claim 1, comprising, in parts by weight: 1-3 parts of hydrogen peroxide, 0.1-1.5 parts of N-methyl succinamide, 0.1-2.0 parts of sodium p-pivaloyloxybenzene sulfonate, 0.01-0.5 part of anionic surfactant, 0.5-2.5 parts of amphoteric surfactant, 0.05-1.0 part of glycollic acid and 92-98 parts of water.
3. The disinfecting solution of claim 1 or 2, wherein the anionic surfactant is sodium lauroyl hydroxymethylethanesulfonate and the amphoteric surfactant is N-octyl-diaminoethylglycine hydrochloride.
4. The disinfecting solution of claim 1, comprising, in parts by weight: 1.5-2.5 parts of hydrogen peroxide, 0.3-1.0 part of N-methyl succinamide, 0.3-1.2 parts of sodium p-pivaloyloxybenzene sulfonate, 0.05-0.3 part of sodium lauroyl hydroxymethyl ethanesulfonate, 0.8-2.0 parts of N-octyl-diaminoethyl glycine hydrochloride, 0.1-0.5 part of glycolic acid and 92-98 parts of water.
5. The method for preparing the disinfecting solution of any one of claims 1 to 4, comprising the steps of:
1) uniformly mixing hydrogen peroxide and water to obtain a solution A;
2) sequentially adding N-methylsuccinamide and sodium p-pivaloyloxybenzene sulfonate into the solution A and uniformly mixing to obtain a solution B;
3) and adding a surfactant and glycolic acid into the solution B and uniformly mixing.
6. The preparation method of claim 5, wherein in the step 1), the mixture is uniformly mixed by adopting a stirring mode, and the stirring speed is 50-100 rpm.
7. The preparation method according to claim 5 or 6, wherein in the step 2), the mixture is uniformly mixed by adopting a stirring mode, and the stirring speed is 50-100 rpm.
8. The preparation method according to claim 5 or 6, wherein in the step 3), the mixture is uniformly mixed by adopting a stirring mode, and the stirring speed is 100-200 rpm.
9. Use of the disinfecting solution of any one of claims 1 to 4 or the process for preparing the disinfecting solution of any one of claims 5 to 8 for environmental disinfection.
10. A disinfection method characterized in that the disinfection solution according to any one of claims 1 to 4 is used to contact an object to be treated.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477438A (en) * | 1982-11-12 | 1984-10-16 | Surgikos, Inc. | Hydrogen peroxide composition |
| CN101053330A (en) * | 2006-04-12 | 2007-10-17 | 拉萨绿能科技实业有限公司 | Disinfectant for improving hydrogen peroxide bactericidal activity |
| CN112868665A (en) * | 2021-01-13 | 2021-06-01 | 东莞市八谷生物技术有限公司 | Disinfectant containing supermolecule silver and preparation method thereof |
-
2021
- 2021-09-09 CN CN202111055483.1A patent/CN113693064A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477438A (en) * | 1982-11-12 | 1984-10-16 | Surgikos, Inc. | Hydrogen peroxide composition |
| CN101053330A (en) * | 2006-04-12 | 2007-10-17 | 拉萨绿能科技实业有限公司 | Disinfectant for improving hydrogen peroxide bactericidal activity |
| CN112868665A (en) * | 2021-01-13 | 2021-06-01 | 东莞市八谷生物技术有限公司 | Disinfectant containing supermolecule silver and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 无: "无", 《爱化学》 * |
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